WO2011020610A1 - Drug delivery systems (wafer) for pediatric use - Google Patents
Drug delivery systems (wafer) for pediatric use Download PDFInfo
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- WO2011020610A1 WO2011020610A1 PCT/EP2010/005083 EP2010005083W WO2011020610A1 WO 2011020610 A1 WO2011020610 A1 WO 2011020610A1 EP 2010005083 W EP2010005083 W EP 2010005083W WO 2011020610 A1 WO2011020610 A1 WO 2011020610A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Definitions
- the present invention relates to drug delivery compositions in the form of thin water- soluble films (wafers), which contain particles that comprise at least one active ingredient -which is not an estrogen and/or a progestin and/or an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate- and at least one protective agent.
- the protective agent provides effective taste-masking of the active ingredient due to limited release of the active ingredient in the mouth.
- the active ingredient is hence not absorbed via the buccal route, but rather via the enteral (per-oral) route.
- the particles contained in the wafer provided by the present invention have a particle size of below 40 ⁇ m thereby resulting in an acceptable sensation in the mouth while dissolving. Such wafers are especially suitable for pediatric use.
- the dosage forms must safeguard all quality aspects (such as dose uniformity, purity, stability etc.) and an appropriate bioavailability of the drug substance.
- the dosage form must be easy to administer to children not only by medically trained personnel, but also by their parents.
- the drug product should flexibly allow for dose adaptation to e.g. the individual body weight.
- the excipients to be used must of course be safe and non-toxic to children. Unfortunately, not all excipients considered as safe in adults can be used equally in children, at least not in similar amounts (e.g. ethanol, propylene glycol, polyethylene glycol, several surfactants, antioxidants, and preservatives).
- socio-cultural aspects have to be
- organoleptic properties must be palatable or acceptable.
- Transdermal patches can be inconvenient and uncomfortable as well as rather expensive to produce. Furthermore, the drug flux through the skin can also raise very complex dosing issues. Suppositories often exhibit high variations in bioavailability.
- liquids are considered particularly useful for children.
- liquids can be be relatively expensive to formulate, package and transport.
- Taste masking of drug substances in liquid dosage forms is a real challenge as even encapsulated drug substances can be liberated already in the dosage form by diffusion to the liquid phase. Therefore, liquid dosage forms are often provided as a taste-masked powder for reconstitution.
- the taste masking of such liquid dosage forms is very efficient immediately after reconstitution, the unpleasant taste typically increases within the usage time of the drug product, e.g. within one to two weeks.
- parents are often unable to precisely measure the required amount of water when
- Tablets that can be dissolved in a liquid before ingestion can also be useful. However, they can also be quite inconvenient in that they require liquid and a drinking container to be provided. Furthermore, time is required for disintegration and/or dissolution, even when effervescent tablets are used. Finally, these drug delivery systems can be quite messy as they typically leave a particulate and/or scum in the glass. Rapid in-mouth disintegrating tablets, such as chewable or self disintegrating tablets offer great convenience. However, chewable or self-disintegrating tablets often present real taste masking problems as the act of chewing can disrupt protective coatings. Furthermore, chewable or self-disintegrating tablets are often associated with an unpleasant mouthfeel.
- Texture is very important, as well as taste. Texture is determined by a number of factors: graininess and viscosity and hardness and stickiness. Beside this, the changes of these mechanical properties during mastication are decisive for the acceptability of the sensation in the mouth.
- the sensation threshold depends on grain hardness, form and changes during mastication. If the grains adsorb water easily or if they dissolve in saliva the sensation threshold is often higher than for grains that maintain the mechanical properties. For a selection of grains the threshold was found to lie between 23 ⁇ ms for cellulose and 50 ⁇ ms Casein. These are the examples showing the lowest sensation threshold of all grains tested. Convincingly these results correlate with the Danisco tests for drinking yoghurt.
- Any encapsulation process for taste masking must lead to grains that do not change their properties during mastication.
- Such delivery systems should be especially suitable for pediatric use, i.e. for use in adolescents in the age group of up to 18 years (0 to 18 years).
- the present inventor has provided a drug delivery system which, on the one hand, takes advantage of the attractive properties of wafers, but which, one the other hand, ensures that the unpleasant taste of the active ingredient(s) is effectively masked. This has been achieved by ensuring that once the wafer matrix is (quickly) dissolved in the saliva the active ingredient is, due to the presence of an appropriate protective agent, not dissolved in the mouth (and hence not administered via the buccal route), but is rather, by normal deglutition, transported to the stomach and/or the intestine where the active ingredient is effectively released.
- the drug delivery system of the invention is flexible in the sense that it may easily be adapted to a system which is bioequivalent to a standard IR oral tablet or capsule reference product.
- Chewable taste-masked pharmaceutical compositions are described in US 4,800,087.
- Taste-masked orally disintegrating tablets (ODTs) are described in US 2006/0105038.
- Taste-masking coating systems are described in WO 00/30617.
- Taste-masked wafers are described in WO 03/030883.
- Taste-masked powders and granules are described in EP 1 787 640.
- Medicament-containing particles and solid preparations containing the particles are described in US 2007/0148230.
- Non-mucoadhesive film dosage forms and techniques and methodologies for retarding the absorption of drugs from orally disintegrating films through the oral mucosa are described in WO 2008/040534. According to this document, mixing of donepezil with Eudragit ® EPO results in immediate release characteristics of the active compound.
- Solid dosage forms containing an edible alkaline agent as taste masking agent are described in WO 2007/109057.
- compositions and methods for mucosal delivery are described in WO 00/42992. This document further discloses dosage units wherein the active agent is encapsulated within a polymer.
- compositions comprising sustained-release particles are described in US 7,255,876.
- WO 2007/074472 teaches that filler particles, e.g. having a particle size of >100 ⁇ m, give a coarse, gritty or sandy mouth feel when ingested as a mouth-dissolving tablet. Furthermore, this document discloses means to improve the mouth feel.
- Xu et al., IntJ Pharm 2008; 359; 63 describe taste masking microspeheres for orally disintegrating tablets. However, the active agent is released relatively fast from these particles and complete taste masking is not achieved.
- US 2007/0292479 describes film-shaped systems for transmucosal buccal application. Furthermore, the film-shaped systems described in US 2007/ 0292479 contain high amounts of cyclodextrin.
- the present invention relates to a unit dosage form comprising a thin water-soluble film matrix, wherein
- said film matrix comprises at least one water-soluble matrix polymer; b) said film matrix comprises particles where said particles comprise at least one active ingredient and at least one protective agent, and where said particles have a d 9 o particle size of ⁇ 40 ⁇ m; and
- said film matrix has a thickness of ⁇ 300 ⁇ m
- the active ingredient is not an estrogen and/or a progestin and/or an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate.
- a grain size of below 40 ⁇ m allows for safe application for children. Thereby it is assured that the application does not appear grainy as the dosage form is applied.
- Unit dosage forms of this type comprising a progestin or a progestin and an estrogen are already described in PCT/EP2009/060298 which are not within the scope of the present invention and unit dosage forms of this type comprising an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate alone or together with a progestin and/or an estrogen are already described in EP 09167733.6 which are not within the scope of this invention.
- Other aspects of the present invention will be apparent from the below description and the appended claims.
- active ingredient is intended to mean any of a variety of pharmaceutical actives, medicaments and bioactive substances with the provisio that active ingredient does not mean an estrogen and/or a progestin.
- Examples of basic drugs as an "active ingredient” include, but are not limited to, levobetaxolol hydrochloride, roxithromycin, dicyclomine hydrochloride, montelukast sodium, dextromethorphan hydrobromide, diphenhydramine hydrochloride, orbifloxacin, ciprofloxacin, enoxacin, grepafloxacin, levofloxacin, lomefloxacin, nalidixic acid, acycloguanosine, tinidazole, deferiprone, cimetidine.
- acidic drugs as an "active ingredient” include, but are not limited to, nicotinic acid, mefanamic acid, indomethacin, diclofenac, repaglinide, ketoprofen, ibuprofen, valproic acid, lansoprazole, ambroxol, omeprazole, acetaminophen, topiramate, amphotericin B, and carbemazepime.
- any of a variety of pharmaceutical actives, medicaments and bioactive active substances may be used in forming the complexates.
- the following is a non-exhaustive list of exemplary actives.
- useful drugs include ace-inhibitors, antiangina! drugs, anti-arrhythmias, anti-asthmatics, anti-cholesterolemics, analgesics, anesthetics, anticonvulsants, antidepressants, anti-diabetic agents, anti-diarrhea preparations, antidotes, antihistamines, anti-hypertensive drags, anti-inflammatory agents, anti-lipid agents, anti- manics, anti-nauseants, anti-stroke agents, anti-thyroid preparations, anti-tumor drugs, anti-viral agents, acne drags, alkaloids, amino acid preparations, anti-tussives, anti-uricemic drugs, anti-viral drags, anabolic preparations, systemic and non-systemic anti -infective agents, antineoplastics, antiparkinsonian agents, anti-rheumatic agents, appetite stimulants, biological response modifiers, blood modifiers, bone metabolism regulators, cardiovascular agents, central nervous system
- hypercalcemia and hypocalcemia management agents include hypercalcemia and hypocalcemia management agents, immunomodulators, and others.
- immunosuppressives migraine preparations, motion sickness treatments, muscle relaxants, obesity management agents, osteoporosis preparations, oxytocics, parasympatholytics, parasympathomimetics, prostaglandins, psychotherapeutic agents, respiratory agents, sedatives, smoking cessation aids, sympatholytics, tremor preparations, urinary tract agents, vasodilators, laxatives, antacids, ion exchange resins, anti-pyretics, appetite suppressants, expectorants, anti-anxiety agents, antiulcer agents, anti-inflammatory substances, coronary dilators, cerebral dilators, peripheral vasodilators, psycho-tropics, stimulants, anti-hypertensive drugs,
- vasoconstrictors migraine treatments, antibiotics, tranquilizers, anti-psychotics, anti- tumor drugs, anti-coagulants, anti-thrombotic drugs, hypnotics, anti-emetics, anti- nauseants, anti-convulsants, neuromuscular drugs, hyper- and hypo-glycemic agents, thyroid and anti-thyroid preparations, diuretics, anti-spasmodics, terine relaxants, anti- obesity drugs, erythropoietic drugs, anti-asthmatics, cough suppressants, mucolytics, DNA and genetic modifying drugs, and combinations thereof.
- medicating active ingredients contemplated for use in the present invention include antacids, H 2 - antagonists, and analgesics.
- antacid dosages can be prepared using the ingredients calcium carbonate alone or in combination with magnesium hydroxide, and/or aluminum hydroxide.
- antacids can be used in combination with H2- antagonists.
- Analgesics include opiates and opiate derivatives, such as oxycodone, ibuprofen, aspirin, acetaminophen, and combinations thereof that may optionally include caffeine.
- anti-diarrheals such as immodium AD, anti-histamines, anti-tussives, decongestants, vitamins, and breath fresheners.
- Common drugs used alone or in combination for colds, pain, fever, cough, congestion, runny nose and allergies, such as acetaminophen, chlorpheniramine maleate, dextromethorphan, pseudoephedrine HCI and diphenhydramine may be included in the film compositions of the present invention.
- anxiolytics such as alprazolam; anti-psychotics such as clozopin and haloperidol; non-steroidal antiinflammatories (NSAID's) such as dicyclofenacs and etodolac, anti-histamines such as loratadine, astemizole,
- NSAID's non-steroidal antiinflammatories
- dicyclofenacs and etodolac anti-histamines
- anti-histamines such as loratadine, astemizole
- nabumetone, and Clemastine anti-emetics such as granisetron hydrochloride and nabilone; bronchodilators such as Bentolin(R), albuterol sulfate; antidepressants such as fluoxetine hydrochloride, sertraline hydrochloride, and paroxtine hydrochloride; antimigraines such as Imigra(R), ACE-inhibitors such as enalaprilat, captopril and lisinopril; anti-Alzheimer's agents, such as nicergoline; and Ca -antagonists such as nifedipine, and verapamil hydrochloride.
- anti-emetics such as granisetron hydrochloride and nabilone
- bronchodilators such as Bentolin(R), albuterol sulfate
- antidepressants such as fluoxetine hydrochloride, sertraline hydrochloride, and paroxtine hydrochloride
- H2-antagonists which are contemplated for use in the present invention include cimetidine, ranitidine hydrochloride, famotidine, nizatidien, ebrotidine, mifentidine, roxatidine, pisatidine and aceroxatidine.
- Active antacid ingredients include, but are not limited to, the following: aluminum hydroxide, dihydroxyaluminum aminoacetate, aminoacetic acid, aluminum phosphate, dihydroxyaluminum sodium carbonate, bicarbonate, bismuth aluminate, bismuth carbonate, bismuth subcarbonate, bismuth subgallate, bismuth subnitrate, bismuth subsilysiiate, calcium carbonate, calcium phosphate, citrate ion (acid or salt), amino acetic acid, hydrate magnesium aluminate sulfate, magaldrate, magnesium
- aluminosilicate magnesium carbonate, magnesium glycinate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, milk solids, aluminum mono-ordibasic calcium phosphate, iricalcium phosphate, potassium 0 bicarbonate, sodium tartrate, sodium bicarbonate, magnesium aluminosilicates, tartaric acids and salts.
- the active ingredient may be comprised in the particles in its free form or may be comprised in form of a pharmaceuticaly acceptable salt, solvate or derivative thereof, such as in the form of an ether, ester or a complex thereof, e.g. a cyclodextrin complex.
- cyclodextrin complex or "active ingredientcomplexed with cyclodextrin” is intended to mean a complex between an active ingredient and a cyclodextrin, wherein the active ingredient molecule is at least partially inserted into the cavity of a cyclodextrin molecule.
- the molar ratio between the active ingredient and the cyclodextrin may be adjusted to any desirable value.
- a molar ratio between the active ingredient and the cyclodextrin is from about 2: 1 to 1: 10, preferably from about 1: 1 to 1:5, most preferably from about 1: 1 to 1:3, such as 1: 1 or 1 :2.
- the active ingredient molecule may at least partially be inserted into the cavity of two or more cyclodextrin molecules, e.g. a single active ingredient molecule may be inserted into two cyclodextrin molecules to give 1:2 ratio between active ingredient and cyclodextrin.
- the complex may contain more than one active ingredient molecule at least partially inserted into a single cyclodextrin molecule, e.g. two active ingredient molecules may be at least partially inserted into a single cyclodextrin molecule to give a 2:1 ratio between active ingredient and cyclodextrin.
- Complexes between an active ingredient and cyclodextrins may be obtained by methods known in the art.
- cyclodextrin is intended to mean a cyclodextrin or a derivative thereof as well as mixtures of various cyclodextrins, mixtures of various derivatives of
- the cyclodextrin may be selected from the group consisting of ⁇ -cyclodextrin, ⁇ - cyclodextrin, ⁇ -cyclodextrin and derivatives thereof.
- the cyclodextrin may be modified such that some or all of the primary or secondary hydroxyl groups of the macrocycle are alkylated or acylated. Methods of modifying these hydroxyl groups are well known to the person skilled in the art and many such modified cyclodextrins are commercially available.
- R is an optionally substituted Ci -6 -alkyl, an optionally substituted C 2 - 6 -alkenyl, an optionally substituted C 2 - 6 -alkynyl, an optionally substituted aryl or heteroaryl group.
- R may be a methyl, an ethyl, a propyl, a butyl, a pentyl, or a hexyl group, i.e. 0-C(O)-R may be an acetate.
- the hydroxyl groups may be per-benzylated, per-benzoylated, benzylated or benzoylated on just one face of the macrocycle, i.e. only 1, 2, 3, 4, 5 or 6 hydroxyl groups is/are benzylated or benzoylated.
- the hydroxyl groups may also be per-alkylated or per-acylated, such as per-methylated or per-acetylated, alkylated or acylated, such as methylated or acetylated, on just one face of the macrocycle, i.e. only 1, 2, 3, 4, 5 or 6 hydroxyl groups is/are alkylated or acylated, such as methylated or acetylated.
- cyclodextrins are hydroxypropyl- ⁇ - cyclodextrin, DIMEB, RAMEB and sulfoalkyl ether cyclodextrins, such as sulfobutyl ether cyclodextrin (available under the trademark Captisol ® ).
- sulfoalkyl ether cyclodextrins such as sulfobutyl ether cyclodextrin (available under the trademark Captisol ® ).
- Captisol ® sulfobutyl ether cyclodextrin
- Ci -6 -alkyl is intended to mean a linear or branched saturated hydrocarbon chain having from one to six carbon atoms, such as methyl; ethyl; propyl, such as n-propyl and isopropyl; butyl, such as n-butyl, isobutyl, sec-butyl and tert-butyl; pentyl, such as n-pentyl, isopentyl and neopentyl; and hexyl, such as n- hexyl and isohexyl.
- Ci -4 -alkyl is intended to mean a linear or branched saturated hydrocarbon chain having from one to four carbon atoms, such as methyl; ethyl; propyl, such as n-propyl and isopropyl; and butyl, such as n-butyl, isobutyl, sec-butyl and tert-butyl.
- the unit dosage form of the invention does not contain a cyclodextrin.
- the particles containing the active ingredient should be prepared in such a way that as little active ingredient as possible is released in the mouth, while as much active ingredient as possible is released in the stomach or, optionally, in the small intestine. This can be achieved by combining the active ingredient with a protective agent as will be discussed infra.
- This aforementioned embodiment is especially required if the active ingredient has an unpleasant, for instance bitter taste (in the mouth) and/or if the active ingredient has to be protected, for instance because it is instable and prone to degradation if not protected.
- the active ingredient has not to be protected it can be present in the matrix of the dosage unit in dispersed, preferably molecularly dispersed form or in amorphous form or in form of small crystals.
- the typical residence time of disintegrating dosage forms in the mouth is typically below 3 minutes.
- the protective agent in order to effectively mask the unpleasant taste of the active ingredient, the protective agent must ensure that no or only very limited amounts of the active ingredient is dissolved under conditions simulating the conditions prevailing in the mouth. More particularly, it is preferred that less than 25% (w/w), such as less than 20% (w/w), more preferably less than 15% (w/w), such as less than 10% (w/w), most preferably less than 5% (w/w) of the active ingredient is dissolved from the unit dosage form within 3 minutes as determined in an in vitro dissolution experiment representing the conditions in the mouth. Basically, the dosage form is placed onto the bottom of a glass beaker.
- simulated saliva pH 6.0 composition: 1.436 g disodium phosphate dihydrate, 7.98 g monopotassium phosphate, and 8.0 g sodium chloride are dissolved in 950 ml water, adjusted to pH 6.0 and made up to 1000 ml) at 37°C as dissolution medium is added into the beaker.
- the experiment is performed without any stirring or shaking (except for a gentle shaking within the first five seconds of the experiment in order to safeguard complete wetting of the dosage form), provided that the dosage form is formulated in such a way that it disintegrates completely within 3 minutes applying this procedure.
- stirring or shaking may be applied in a way that ensures complete disintegration of the dosage form within 3 minutes. After 3 minutes, the content of the beaker is inspected visually, and a sample of the liquid is drawn, filtered and analyzed for the content of the drug substance.
- the dissolution test described in Xu et al., Int J Pharm 2008;359;63 may be applied.
- less than 20% (w/w), more preferably less than 15% (w/w), most preferably less than 10% (w/w) of the active ingredient is dissolved from the protected particles within 5 minutes as determined by a dissolution apparatus type II using distilled water at 37°C as the dissolution media and 100 rpm as the stirring rate.
- the active ingredient is quickly and effectively released in the stomach and/or the intestine.
- this effect may be simulated by in vitro dissolution tests, and it can reasonably be assumed that effective release of the active ingredient in the stomach and/or the intestine is achieved if at least 70% (w/w), more preferably at least 80% (w/w), most preferably at least 90% (w/w) of the active ingredient is dissolved from the unit dosage form within 30 minutes as determined by United States Pharmacopoeia (USP) XXXI Paddle Method (apparatus 2) using 900-1000 ml of a suitable dissolution medium at 37°C and 50-100 rpm, preferably either 50, 75 or 100 rpm, as the stirring rate.
- USP United States Pharmacopoeia
- Appatus 2 using 900-1000 ml of a suitable dissolution medium at 37°C and 50-100 rpm, preferably either 50, 75 or 100 rpm, as the stirring rate.
- the unit dosage form may be assayed for a shorter period of time under similar conditions.
- the suitable dissolution medium may be selected so that it reflects physiological conditions in the stomach and/or the intestine and specific properties of the unit dosage form.
- a suitable dissolution medium may be selected from e.g. water, aqueous buffer solutions of pH 1-8 (such as pH 1.0, 1.2, 1.3, 2.0, 4.5, 6.0 and 6.8), aqueous buffer solutions of pH 1-8 (such as pH 1.0, 1.2, 1.3, 2.0, 4.5, 6.0 and 6.8) with the addition of 0.1-3% (w/v) sodium dodecyl sulphate, simulated gastric fluid, simulated intestinal fluid (fasted or fed state).
- compositions of simulated body fluids are described in the USP XXXI. There are, however, other compositions of simulated body fluids known in the pharmaceutical literature. As mentioned supra, the exact composition of the dissolution medium should be selected in such a way that it reflects the physiological conditions in the stomach and/or the intestine and the specific properties, for instance the solubility of the active ingredient of the unit dosage form.
- protective agent A variety of materials, which are all well-known to the person skilled in the art, can be employed as the protective agent according to the present invention.
- specific examples of such protective agents include cationic polymethacrylates and waxes.
- the protective agent is a cationic polymethacrylate copolymer based on di-Ci- 4 -alkyl-amino-Ci -4 -alkyl methacrylates and neutral methacrylic acid Ci- 6 -alkyl esters.
- the cationic polymethacrylate is a copolymer based on dimethylaminoethyl methacrylate and neutral methacrylic acid C 1-4 -alkyl esters, such as a copolymer based on dimethyl-aminoethyl methacrylate, methacrylic acid methyl ester and methacrylic acid butyl ester.
- a particular preferred cationic polymethacrylate is poly(butyl methacrylate, (2-dimethyl aminoethyl) methacrylate, methyl methacrylate) 1:2:1.
- the cationic polymethacrylates mentioned above typically have an average molecular mass in the range of from 100,000 to 500,000 Da, such as an average molecular mass in the range of from 100,000 to 300,000 Da, e.g. an average molecular mass in the range of from 100,000 to 250,000 Da, preferably an average molecular mass in the range of from 100,000 to 200,000 such as an average molecular mass in the range of from 125,000 to 175,000 Da, e.g. an average molecular mass of about 150,000 Da.
- Such cationic polymethacrylates are available from Degussa, Germany, under the trade name Eudragit ® E. In particular Eudragit ® E 100 is preferred.
- the protective agent is a wax.
- waxes examples include animal waxes, such as beewax, Chinese wax, shellac wax, spermaceti wax and wool wax; vegetable waxes, such as carnauba wax, bayberry wax, candelilla wax, castor wax, esparto wax, ouricury wax, rice bran wax and soy wax; mineral waxes, such as ceresin wax, montan wax, ozocerite wax and peat wax;
- petroleum waxes such as paraffin wax and microcrystalline wax
- synthetic waxes such as polyethylene waxes, Fischer-Tropsch waxes, esterified and/or saponified waxes, substituted amide waxes and polymerised ⁇ -olefines.
- a particular preferred wax is carnauba wax.
- the weight ratio between the progestin and the wax is typically in the range of from 1: 1 to 1:4, such as about 1: 1, about 1:2, about 1:3 or about 1:4.
- the particles comprising the active ingredient and the protective agent should release as little active ingredient as possible in the mouth, while as much active ingredient as possible should be dissolved in the stomach and/or the intestine.
- This can be achieved, e.g., by embedding the active ingredient in the protective agent, for example in such a way that the active ingredient is present in a solid dispersion in the protective agent.
- the protective agent is a cationic polymethacrylate.
- the active ingredient may be coated with the protective agent.
- the protective agent is a wax.
- solid dispersion is used in its commonly accepted meaning, i.e. as a dispersion, wherein the dispersed phase consists of amorphous particles or crystalline particles or individual molecules (molecular dispersion).
- solid dispersion means any solid system in which a component A (the active ingredient) is dispersed at a level of small particles or even at the molecular level (molecular dispersion) within another component B (such as a protective agent).
- the term “molecularly dispersed” or “molecular dispersion” is used in its commonly accepted meaning, i.e. as a dispersion, wherein the dispersed phase consists of individual molecules.
- the term “molecularly dispersed” or “molecular dispersion” means any solid, semi-solid or liquid system in which a component A (an actice ingredient) is dispersed at the molecular level within another component B (such as a protective agent), so that component A neither can be detected in crystalline form by X-ray diffraction analysis, nor be detected in particulate form, by any microscopic technique. It should also be understood that component A is dissolved in component B regardless of the nature and physical state of B. Thus, the term “molecularly dispersed” may be used interchangeably with the term “molecularly dissolved”.
- the particle size of the particles comprising the active ingredient and the protecting agent is, at least to a certain extent, dependent on the applied protective agent.
- the d 90 particle size measurement leads in some cases to unplausible high values which may beattributed to the formation of secondary aggregates and agglomerates. Such aggregates and agglomerates are easily separated during the manufacturing of the wafers.
- the particle size values specified below refer to the primary particles and not to the particle size of aggregates and agglomerates.
- the particles comprising the active ingredient and the protective agent have a d 90 particle size of ⁇ 40 ⁇ m, and a d 50 particle size of ⁇ 15 ⁇ m.
- d 90 particle size is intended to mean that the particle size distribution is so that at least 90% of the particles have a particle diameter of less than the specified value, calculated from the volume distribution curve under the
- d 50 particle size is intended to mean that the particle size distribution is so that at least 50% of the particles have a particle diameter of less than the specified value, calculated from the volume distribution curve under the presumption of spherical particles.
- particle size a particle size distribution
- particle diameter a particle diameter of a particle.
- d 90 a particle diameter of a particle.
- d 5 o a particle size distribution
- the particles may be spherical, substantially spherical, or non-spherical, such as irregularly shaped particles or ellipsoidally shaped particles.
- the particle size distribution of the particles comprising the active ingredient and the protective agent, when incorporated in the wafer, may be determined by dissolving the film forming matrix, separation of the protected particles, and drying the protected particles.
- the particle size distribution of the resulting particles may be determined as described above, e.g. by laser diffraction.
- a Sympatec Helos laser diffracto meter with a Sympatec Rhodos module aerial dispersion system can be used.
- these particles typically constitute less than 60% by weight of the unit dosage form, preferably less than 50% by weight of the unit dosage form, more preferably less than 40% by weight of the unit dosage form.
- the amount of particles comprising the active ingredient and the protective agent is dependent on the potency of the selected active ingredient. Accordingly, the particles comprising the active ingredient and the protective agent generally constitute 0.1-50% by weight of the unit dosage form, preferably 1-40%, such as 2-40%, e.g. 5-30% by weight of the unit dosage form. Specific values include about 12%, about 15%, about 20%, and about 30% by weight of the unit dosage form.
- the particles comprising the active ingredient(s) and the protective agent may contain additional excipients.
- additional excipients may be included in a preferred embodiment.
- the particles consist essentially of the active ingredient(s) and the protective agent.
- the encapsulation efficiency is high and typically above 80%, such as above 85%, e.g. above 90%. Thus, the encapsulation efficiency is typically in the range of from 80-100%, such as in the range of from 85-100%, e.g. in the range of from 90-100%.
- the term "encapsulation efficiency" means the ratio of the amount of active ingredient incorporated in the protected particles versus the amount of active ingredient used for manufacturing of the protected particles.
- water-soluble film matrix refers to a thin film which comprises, or consists of, a water-soluble polymer, particles comprising at least one active ingredient and at least one protective agent, and optionally other auxiliary components dissolved or dispersed in the water-soluble polymer.
- water-soluble polymer refers to a polymer that is at least partially soluble in water, and preferably fully or predominantly soluble in water, or absorbs water. Polymers that absorb water are often referred to as being "water- swellable polymers".
- the materials useful for the present invention may be water- soluble or water-swellable at room temperature (about 20 0 C) and other temperatures, such as temperatures exceeding room temperature. Moreover, the materials may be water-soluble or water-swellable at pressures less than atmospheric pressure.
- the water-soluble polymers are water- soluble, or water-swellable having at least 20% by weight water uptake.
- Water- swellable polymers having 25% by weight, or more, water uptake, are also useful.
- the unit dosage forms of the present invention formed from such water-soluble polymers are desirably sufficiently water-soluble to be dissolvable upon contact with bodily fluids, in particular saliva.
- the water-soluble matrix polymer (typically constituting the major part of the water- soluble film matrix) can be selected from the group consisting of a cellulosic material, a synthetic polymer, a gum, a protein, a starch, a glucan and mixtures thereof.
- cellulosic materials suitable for the purposes described herein include carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethylpropyl cellulose, hydroxypropylmethyl cellulose and combinations thereof. Particularly preferred cellulosic materials are hydroxypropylmethyl cellulose and hydroxypropyl cellulose, in particular hydroxypropylmethyl cellulose.
- synthetic polymers include polymers commonly used as immediate-release (IR) coatings for pharmaceuticals, such as the polyvinyl alcohol polyethylene glycol (PVA-PEG) copolymers, which are commercially available in different grades under the trademark Kollicoat ® IR.
- synthetic polymers include polyacrylic acid and polyacrylic acid derivatives.
- synthetic polymers in particular a PVA-PEG copolymer
- This advantageous stabilising effect by the synthetic polymer, in particular a PVA-PEG copolymer will probably occur in other active ingredients, too. This effect is particularly pronounced when the active agent is dispersed, in particular molecularly dispersed, in the film matrix.
- water-soluble gums examples include gum arable, xanthan gum, tragacanth, acacia, carageenan, guar gum, locust bean gum, pectin, alginates and combinations thereof.
- Useful water-soluble protein polymers include gelatine, zein, gluten, soy protein, soy protein isolate, whey protein, whey protein isolate, casein, levin, collagen and combinations thereof.
- useful starches include gelatinised, modified or unmodified starches.
- the source of the starches may vary and include pullulan, tapioca, rice, corn, potato, wheat and combinations thereof.
- Additional water-soluble polymers which may be used in accordance with the present invention, include dextrin, dextran and combinations thereof, as well as chitin, chitosin and combinations thereof, polydextrose and fructose oligomers.
- the amount of active ingredient incorporated in the unit dosage form of the invention is, of course, also dependent on the potency of the selected active ingredient, but will generally be in the range of from 0.1-30% (w/w) calculated on the basis of the unit dosage form. Typically, the amount of active ingredient incorporated in the unit dosage form of the invention is 0.5-25% (w/w), such as 1-20% (w/w), preferably
- the amount (dosage) of the active ingredient in the unit dosage form has to be adopted for pediatric use depending on the nature of the active ingredient. Normally the daily amount needed and to be administered to children is lower than the amount which has to be administered per day to an adult person. In some cases it may also be required to administer higher daily doses to children than to adults, for instance in case of higher metaboliv turnover of an active ingredient in children.
- the unit dosage form of the invention may include a variety of various auxiliary components, such as taste-masking agents; organoleptic agents, such as sweeteners, taste modifiers and flavours, anti- and de-foaming agents; plasticizing agents; surfactants; emulsifying agents; agents improving the wetting of the particles; thickening agents; binding agents; cooling agents; saliva-stimulating agents, such as menthol; antimicrobial agents; colorants; etc.
- auxiliary components such as taste-masking agents; organoleptic agents, such as sweeteners, taste modifiers and flavours, anti- and de-foaming agents; plasticizing agents; surfactants; emulsifying agents; agents improving the wetting of the particles; thickening agents; binding agents; cooling agents; saliva-stimulating agents, such as menthol; antimicrobial agents; colorants; etc.
- organoleptic agents such as sweeteners, taste modifiers and flavours, anti- and de-foaming agents
- plasticizing agents such as surfact
- the unit dosage form does not contain an absorption enhancer.
- Suitable sweeteners include both natural and artificial sweeteners.
- suitable sweeteners include, e.g.: a) water-soluble sweetening agents such as sugar alcohols, monosaccharides, disaccharides and polysaccharides such as maltit, xylit, mannit, sorbit, xylose, ribose, glucose (dextrose), mannose, galactose, fructose (levulose), sucrose (sugar), maltose, invert sugar (a mixture of fructose and glucose derived from sucrose), partially hydrolyzed starch, corn syrup solids, dihydrochalcones, monellin, steviosides, and glycyrrhizin; b) water-soluble artificial sweeteners such as the soluble saccharin salts, i.e., sodium or calcium saccharin salts, cyclamate salts, the sodium, ammonium or calcium salt of 3,4- dihydro-6-methyl-l,
- an effective amount of sweetener is utilised to provide the level of sweetness desired for a particular unit dosage form, and this amount will vary with the sweetener selected. This amount will normally be from about 0.01% to about 20% by weight, preferably from about 0.05% to about 10% by weight, of the unit dosage form. These amounts may be used to achieve a desired level of sweetness independent from the flavour level achieved from any optional flavour oils used.
- flavours include natural and artificial flavours. These flavourings may be chosen from synthetic flavour oils and flavouring aromatics, and/or oils, oleo resins and extracts derived from plants, leaves, flowers, fruits and so forth, and combinations thereof.
- Non-limiting examples of flavour oils include: spearmint oil, cinnamon oil, peppermint oil, clove oil, bay oil, thyme oil, cedar leaf oil, oil of nutmeg, oil of sage, and oil of bitter almonds.
- flavours such as vanilla, chocolate, coffee, cocoa and citrus oil, including lemon, orange, grape, lime and grapefruit, and fruit essences including apple, pear, peach, strawberry, raspberry, cherry, plum, pineapple, apricot and the like.
- sweetings can be used individually or in combination.
- Commonly used flavours include mints such as
- aldehydes and esters including cinnamylacetate, cinnamaldehyde, citral, diethylacetal, dihydrocarvyl acetate, eugenyl formate, p-methylanisole, and the like may also be used.
- aldehyde flavourings include, but are not limited to acetaldehyde (apple); benzaldehyde (cherry, almond); cinnamicaldehyde (cinnamon); citral, i.e., alpha citral (lemon, lime); neral, i.e.
- beta citral lemon, lime
- decanal orange, lemon
- ethyl vanillin vanilla, cream
- heliotropine i.e., piperonal (vanilla, cream); vanillin (vanilla, cream); alpha- amyl cinnamaldehyde (spicy fruity flavours); butyraldehyde (butter, cheese);
- valeraldehyde (butter, cheese); citronellal (modified, many types); decanal (citrus fruits); aldehyde C-8 (citrus fruits); aldehyde C-9 (citrus fruits); aldehyde C-12 (citrus fruits); 2-ethyl butyraldehyde (berry fruits); hexenal, i.e. trans-2 (berry fruits); tolyl aldehyde (cherry, almond); veratraldehyde (vanilla); 12,6-dimethyl-5-heptenal, i.e.. melonal (melon); 2-dimethyloctanal (greenfruit); and 2-dodecenal (citrus, mandarin); cherry; grape; essential oils, like menthol; mixtures thereof; and the like.
- flavouring employed is normally a matter of preference, subject to such factors as flavour type, individual flavour, and strength desired.
- the amount may be varied in order to obtain the result desired in the final product. Such variations are within the capabilities of those skilled in the art without the need for undue
- the unit dosage form may also include one or more surfactants, one or more emulsifying agents and/or other agents which aid in improving the wetting of the particles.
- surfactants include nonionic, anionic, cationic and amphoteric surfactants. In particular, nonionic surfactants are preferred.
- nonionic surfactants include, but are not limited to, the following:
- the natural or hydrogenated castor oil may be reacted with ethylene oxide in a molar ratio of from about 1:35 to about 1:60, with optional removal of the PEG component from the products.
- the PEG-hydrogenated castor oils available under the trademark Cremophor ® , are especially suitable, in particular Cremophor ® S9 (polyoxyethylene- 400-monostearate) and Cremophor ® EL (polyoxyl 35 castor oil).
- Polyoxyethylene sorbitan fatty acid esters also known as polysorbates, e.g., mono- and tri-lauryl, palmityl, stearyl and oleyl esters of the type known and commercially available under the trademark Tween ® , including the following products:
- PEG itself does not function as a surfactant
- PEG-fatty acid esters have useful surfactant properties.
- esters of lauric acid, oleic acid and stearic acid are most useful.
- Sorbitan fatty acid esters also known as spans, such as sorbitan monolaurate (span 20), sorbitan monostearate (span 60) and sorbitan monooleate (span 80).
- Polyoxyethylene fatty acid esters e.g., polyoxyethylene stearic acid esters of the type known and commercially available under the trademark Myrj ® .
- Polyoxyethylene-polyoxypropylene co-polymers and block co-polymers e.g., of the type known and commercially available under the trademark Pluronic ® , Emkalyx ® and Poloxamer ®
- lecithins include, in particular, soybean lecithins.
- PEG mono- and di-fatty acid esters such as PEG dicaprylate, also known and commercially available under the trademark Miglyol ® 840, PEG dilaurate, PEG hydroxystearate, PEG isostearate, PEG laurate, PEG ricinoleate, and PEG stearate.
- - Fatty acid monoglycerides e.g., glycerol monostearate and glycerol monolaurate.
- Tocopherol esters e.g., tocopheryl acetate and tocopheryl acid succinate.
- Succinate esters e.g., dioctylsulfosuccinate or related compounds, such as di-[2- ethylhexyl]-succinate.
- anionic surfactants include, but are not limited to, sulfosuccinates, phosphates, sulfates and sulfonates.
- Specific examples of anionic surfactants are sodium lauryl sulfate, ammonium lauryl sulfate, ammonium stearate, alpha olefin sulfonate, ammonium laureth sulfate, ammonium laureth ether sulfate, ammonium stearate, sodium laureth sulfate, sodium octyl sulfate, sodium sulfonate, sodium sulfosuccinimate, sodium tridecyl ether sulfate and triethanolamine lauryl sulfate.
- the amount may be varied in order to obtain the result desired in the final product. Such variations are within the capabilities of those skilled in the art without the need for undue experimentation. In general, amounts from about 0.01% to about 10% by weight of the film matrix are employed, preferably from about 0.05% to 5% by weight of the film matrix are employed.
- the unit dosage form may also include an anti-foaming and/or de- foaming agent, such as simethicone, which is a combination of a polymethylsiloxane and silicon dioxide.
- simethicone acts as either an anti-foaming or de-foaming agent which reduces or eliminates air from the film composition.
- Anti-foaming agents will aid in preventing the introduction of air into the composition, while de-foaming agents will aid removing air from the composition.
- the unit dosage form of the invention is most preferably in the form of a thin film, which dissolves fast mainly due to the large surface area of the film, which wets quickly when exposed to the moist oral environment. Contrary to fast-dissolving tablets, which are usually soft, friable and/or brittle, the film is solid and strong, but still flexible and does not require special packaging. As indicated above, the film is thin and can be carried in the patient's pocket, wallet or pocket book.
- the film may be applied under or on the tongue, to the upper palatine, to the inner cheeks or any oral mucosal tissue, of the female mammal.
- the film may be rectangular, oval, circular, or, if desired, a specific shape, cut to the shape of the tongue, the palatine or the inner cheeks, may be applied.
- the film is rapidly hydrated and will adhere onto the site of application where it then rapidly disintegrates.
- the water-soluble film forming matrix is formed into a dry film which has a thickness of ⁇ 300 ⁇ m, preferably ⁇ 250 ⁇ m, more preferably ⁇ 200 ⁇ m, most preferably ⁇ 150 ⁇ m, such as ⁇ 120 ⁇ m, e.g. ⁇ 100 ⁇ m.
- the thickness of the film matrix is in the range of from 10-150 ⁇ m, such as 20-125 ⁇ m, e.g.
- the thickness of the film matrix is in the range of from 35-90 ⁇ m, in particular in the range of from 40-80 ⁇ m. Specific, and preferred, examples include thicknesses of about 30 ⁇ m, about 40 ⁇ m, about 50 ⁇ m, about 60 ⁇ m, about 70 ⁇ m, about 80 ⁇ m, about 90 ⁇ m, about 100 ⁇ m, about 110 ⁇ m or about 120 ⁇ m.
- the surface dimension (surface area) of the film matrix is typically in the range of from 2-8 cm 2 , such as in the range of from 3-8 cm 2 , e.g. in the range of from 4-7 cm 2 , more preferably in the range of from 4-6 cm 2 .
- Specific, and preferred, examples of the surface area include surface areas of about 3, 3.5, 4, 4.5, 5, 5.5 or 6 cm 2 . Most preferably, the surface area is about 4, 4.5, 5 or 5.5 cm 2 .
- the total weight of the film matrix will typically be in the range of from 5-200 mg, such as in the range of from 5-150 mg, e.g. in the range of from 10-100 mg. More preferably, the total weight of the film matrix is in the range of from 10-75 mg, such as in the range of from 10-50 mg. Specific, and preferred, examples of the weight of the film matrix include weights of about 15 mg, about 20 mg, about 25 mg, about 30 mg, about 35 mg, about 40 mg, about 45 mg or about 50 mg.
- the unit dosage form may be prepared and adhered to a second layer, i.e. a support or backing layer (liner) from which it is removed prior to use, i.e. before being introduced into the oral cavity.
- a support or backing layer liner
- the support or backing material is not water-soluble and may preferably consist of polyethylene-terephthalate, or other suitable materials well known to the skilled person.
- the unit dosage form may contain at least one further active ingredient which - like the first active ingredient termed before as the active ingredient - is incorporated in the unit dosage form in a way allowing the further active ingredient not to be absorbed via the buccal route, i.e. so that as little estrogen as possible is dissolved in the mouth, while as much further active ingredient as possible is dissolved in the stomach and/or the intestine.
- This may be achieved by combining the further active ingredient with a protective agent in a similar way as discussed supra in connection with the first active ingredient.
- the unit dosage form of the invention may be prepared by processes and methods as shown in the examples and as described in WO 2007/073911.
- the protected particles are typically prepared by dissolving the protective agent in a suitable organic solvent after which the active ingredient is added.
- the protective agent is either deposited on the surface of active ingredient particles (e.g. in the case carnauba wax is used as protective agent), or the active ingredient is incorporated as solid dispersion into particles comprising the protective agent and the active ingredient (e.g. in the case a cationic polymethacrylate copolymer is used as protective agent).
- the resulting microparticles are dried and optionally milled and sieved.
- the milling equipment is selected according to the properties of the particles and the desired particle size, e.g. rotor mills or air jet mills may be used.
- the active ingredient may be dissolved together with the protective agent and spray-dried at a suitable temperature, e.g. 30-50 0 C, e.g. at a temperature of about 35°C.
- the protected particles prepared by spray-drying had a ds 0 particle size of about 5-15 ⁇ m.
- the matrix polymer solution is typically prepared by adding the water-soluble matrix polymer to a suitable solvent, such as water or a mixture of an alcohol and water.
- a suitable solvent such as water or a mixture of an alcohol and water.
- the protective agent is a wax (in particular carnauba wax) that a surfactant is added.
- the time and conditions needed to dissolve the water-soluble matrix polymer will depend on the polymer and the solvent used.
- the water-soluble matrix polymer may dissolve easily at room temperature and with only gentle stirring, while in other cases it will be necessary to apply heat and vigorous stirring to the system.
- the mixture is stirred for 1-4 hours, preferably for about 2 hours, or until a solution is obtained.
- the solution is typically stirred at a temperature of 60-80 0 C, such as about 70 0 C.
- the protected particles are optionally dispersed in a small volume of solvent or solvent mixtures and then poured into the matrix polymer solution and mixed thoroughly.
- the final mixing step and the optional pre-dispersing step as well can be performed by any method known to the skilled person, e.g. by using a pestle and mortar, or by stirring with an appropriate stirrer, such as a propeller stirrer, or by high sheer mixing, or by using rotor-stator mixing devices, such as ultra-turrax, and/or applying ultrasound.
- the viscosity of the matrix solution that must hinder the particles from sedimentation during the following processes and at the same time must guarantee a homogenous distribution of the particles.
- the viscosity is dependent of polymer in solution, the solvents used, and the particle or grain size.
- the resulting solution (coating solution) can be used for coating immediately or within a few days, preferably within one day.
- the various amounts of solvent, matrix polymer, etc. are adjusted to reach a solid content of the coating solution of about 5-50% by weight, preferably 10-40% by weight, in particular 20-40% by weight, such as about 25% by weight, about 30% by weight, about 33% by weight, about 35% by weight and about 40% by weight.
- the unit dosage form of the invention may contain a second active ingredient, which may be dispersed, preferably molecularly dispersed, in the water- soluble film matrix.
- the further (second) active ingredient is dissolved in a suitable solvent, such as ethanol and/or propylene glycol.
- This solution can be added to the solvents used for the coating solution before addition of the water-soluble matrix polymer.
- the solution can also be added after the water-soluble matrix polymer is already dissolved. In this case, the solution can be added either before, together or after the addition of the protected particles, before the final mixing step is performed.
- the coating solution is degassed before being spread out on a suitable support or backing layer (liner).
- suitable liners include polyethylene- terephthalate (PET) liners, such as Perlasic ® LF75 (available from Perlen Converting), Loparex ® LF2000 (available from Loparex BV) and Scotchpack ® 9742 (available from 3M Drug delivery Systems).
- PET polyethylene- terephthalate
- the coating solution is spread out with the aid of a spreading box onto a suitable liner and dried for 12-24 hours at room temperature. A thin opaque film is then produced, which is subsequently cut or punched into pieces of the desired size and shape.
- the coating solution is coated as a thin film onto a suitable liner and in-line dried using an automated coating and drying equipment (e.g. by Coatema Coating Machinery GmbH, Dormagen, Germany) using a drying temperature of 40-100 0 C.
- a thin opaque film is then produced, which is subsequently cut or punched into pieces of the desired size and shape.
- the units can be adjusted to specific dosages by adjusting the height, the area, are the content of the compound and may then be administered to warm-blooded animals, incl. humans.
- a unit dosage form comprising a thin water-soluble film matrix, wherein
- said film matrix comprises at least one water-soluble matrix polymer
- said film matrix comprises particles where said particles comprise at least one active ingredient and at least one protective agent, and where said particles have a dgo particle size of ⁇ 40 ⁇ m;
- said film matrix has a thickness of ⁇ 300 ⁇ m
- the active ingredient is not an estrogen and/or a progestin and/or an alkaline earth metal salt of 5-methyl-(6S)-tetrahydrofolate 2.
- polymethacrylate is a copolymer based on methacrylates and neutral methacrylic acid C 1-6 -alkyl esters.
- polymethacrylate is a copolymer based on dimethylaminoethyl methacrylate and neutral methacrylic acid Ci -4 -alkyl esters.
- polymethacrylate is a copolymer based on dimethyl-aminoethyl methacrylate, methacrylic acid methyl ester and methacrylic acid butyl ester.
- polymethacrylate is poly(butyl methacrylate, (2-dimethyl aminoethyl) methacrylate, methyl methacrylate) 1:2:1.
- said water-soluble matrix polymer is selected from the group consisting of a cellulosic material, a gum, a protein, a starch, a synthetic polymer, a glucan, and mixtures thereof.
- cellulosic material is selected from the group consisting of carboxymethyl cellulose, methyl cellulose, ethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxymethylpropyl cellulose and hydroxypropylmethyl cellulose.
- said film matrix has a thickness of ⁇ 250 ⁇ m, preferably ⁇ 200 ⁇ m, such as ⁇ 150 ⁇ m, more preferably ⁇ 120, such as ⁇ 100 ⁇ m. 19.
- said film matrix has a thickness in the range of from 10-150 ⁇ m, such as 20-125 ⁇ m, e.g. 30-100 ⁇ m, preferably 35-90 ⁇ m, more preferably 40-80 ⁇ m.
- unit dosage form according to any of the preceding embodiments, wherein said unit dosage form further comprises at least one further active ingredient.
- the particle size distribution obtained after milling twice as described in Example IA is d 50 about 11 ⁇ m, dg 0 about 25 ⁇ m and d 99 about 35 ⁇ m.
- Example IB Ethinylestradiol/carnauba wax (as illustrative Example)
- the mixture was cooled to 20 0 C at a cooling rate of 20°C/hour to yield the drug containing microparticles coated with Carnauba wax.
- the ethinylestradiol-containing microparticles were filtrated using a cellulose acetate filter membrane and a glass filter unit. The microparticles were subsequently washed with 300 ml ethanol (96%) to remove n-heptane residues and non-encapsulated ethinylestradiol.
- the filtered microparticles were transferred to a glass bowl and dried for 2 hours at 30 0 C.
- the resulting particles had the following particle size distribution: dgn f urn) dTM ( ⁇ m) d on (urn)
- the encapsulation efficiency was greater than 90%.
- Example 1C Ethinylestradiol/Eudra ⁇ it ® E 100 (as illustrative Example for spray-drying) 10 g of ethinylestradiol and 90 g of Eudragit ® E 100 were dissolved in 1000 ml of ethanol (96%) and spray-dried with a laboratory spraydrier (B ⁇ chi 190, Switzerland). The ethinylestradiol was found to be molecularly dispersed in a solid dispersion in the protective agent, as confirmed by X-ray analysis.
- the resulting protected particles wherein the ethinylestradiol is present in molecularly dispersed form in the protective agent, had a dso particle size of 5.5 ⁇ m and a dgo particle size of 13.8 ⁇ m.
- the protected particles are stored protected from heat (e.g. in a refrigerator) until further use.
- the encapsulation efficiency was greater than 90 %.
- Example IA 36 g purified water is heated to 60 0 C and 8 g hydroxy-propyl cellulose (Klucel EF) are added and dissolved after cooling. A clear polymer solution is obtained. 6 g of the powder obtained in Example IA were placed in a beaker and the polymer solution was added stepwise. The particles were homogenously dispersed using a pistil. The obtained dispersion is the coating solution.
- Example IA 32.5 g of purified water is heated to 60 0 C and 8 g polyvinyl acetate - polyethylene glycol - copolymer (Kollicoat IR) are added. The polymer is dissolved after cooling to obtain a transparent polymer solution. 8 g of the particles obtained in Example IA are placed in a beaker and the polymer solution is adedded stepwise. The particles are distributed homogenously using a pistil to obtain the coating solution.
- Kollicoat IR polyvinyl acetate - polyethylene glycol - copolymer
- Example 2A The coating solution obtained in Example 2A is coated to a film using a 800 ⁇ m scraper.
- the film obtained is dried at room temperature.
- the obtained laminate is used to punch single units, so called wafers.
- Example 2B The coating solution obtained in Example 2B is coated to a film using a 800 ⁇ m scraper. The obtained film is dried at room temperature. The obtained laminate is used to punch single units, so called wafers.
- Example 3C The coating solution is degassed and coated as a thin film onto a polyethylene- terephthalate (PET) liner (Perlasic ® LF75) and in-line dried using an automated coating and drying equipment (Coatema Coating Machinery GmbH, Dormagen, Germany). A drying temperature of 70 0 C is applied. An opaque film with a thickness of about 70 ⁇ m is produced. Wafers with a total weight of about 35 mg are obtained by punching out samples of 5 cm 2 size.
- PET polyethylene- terephthalate
- Perlasic ® LF75 Perlasic ® LF75
- a drying temperature of 70 0 C is applied.
- An opaque film with a thickness of about 70 ⁇ m is produced.
- Wafers with a total weight of about 35 mg are obtained by punching out samples of 5 cm 2 size.
- the film matrix contains the active ingredient homogeneously distributed such, that the surface area of the film correlates to the amount of active in a linear manner.
- the surface of the film matrix is consisting of at least once the size, but mostly a multiple of the size required for one dosage to be administered.
- the required dose to by applied for each patient is defined in dependence of the age, height, weight, gender or other defined physiological parameter and provided to the user together with the product.
- the user identifies the required dose by determining the surface area of the film product containing the required dose according to the information provided.
- the user separates the required surface area of the film from the remaining film matrix right before administration.
- Pre-defined separation marks e.g. by tear-off perforation
- a wafer stripe with pre-defined separation marks, from which one or several area parts can be separated at once ( Figure 2).
- Packaging of the wafer stripe may be similar to those also used in the food industry, such as for chewing gums.
- One example is presented in Figure 3.
- Packaging Other technical solutions may be possible, such as e.g. used and established in the market for adhesive stripes.
- the separation marks required to accurately separate the required surface area of the film matrix may be prepared e.g. by perforation, pre-cutting or prepunching with remaining small contact points or any other technical solution established and known by those, skilled in the art.
- the technical solution for the in-situ definition and separation of the required surface area of the film requires, that a technical solution is provided together with the film matrix, e.g. a technical device, which assists the precise separation of the required surface area.
- the technical device may include an additional mechanism inserted into the packaging, which allows a definition of the required size upfront before actuation of the device.
- Such technical solutions are already established in the market e.g. for the application of pre-defined amounts of liquids, as used for example in insulin pens.
- Such devices can optionally have also a mechanism for presentation of the film product after separation of the required area from the wafer stripe to facilitate the removal of the wafer by the user for immediate administration.
- Such technical solutions are known and established in the market e.g. for
- the present invention also relates to a pharmaceutical drug product comprising a thin water-soluble film-matrix, wherein
- said film-matrix comprises a water-soluble polymer and at least one pharmaceutically active compound (active ingredient)
- said pharmaceutically active compound is distributed homogeneously within the matrix so that the amount of pharmaceutically active compound is directly and linearly correlated with the area of the matrix and
- said pharmaceutical drug product is provided in a manner which allows for separation of discrete portions (unit dosage forms) of the pharmaceutical drug product (metering and adjusting the dose according to the area of the separated portion).
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Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012525086A JP2013502388A (en) | 2009-08-19 | 2010-08-19 | Drug delivery system (wafer) for pediatric use |
CN201080036372XA CN102470101A (en) | 2009-08-19 | 2010-08-19 | Drug delivery systems (wafer) for pediatric use |
KR1020127004173A KR20120056824A (en) | 2009-08-19 | 2010-08-19 | Drug delivery systems (wafer) for pediatric use |
EP10745182A EP2467126A1 (en) | 2009-08-19 | 2010-08-19 | Drug delivery systems (wafer) for pediatric use |
US13/391,377 US20120207836A1 (en) | 2009-08-19 | 2010-08-19 | Drug delivery systems (wafer) for pediatric use |
CA2771358A CA2771358A1 (en) | 2009-08-19 | 2010-08-19 | Drug delivery systems (wafer) for pediatric use |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09075378.1 | 2009-08-19 | ||
EP09075378 | 2009-08-19 | ||
EP09075381 | 2009-08-20 | ||
EP09075381.5 | 2009-08-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2011020610A1 true WO2011020610A1 (en) | 2011-02-24 |
Family
ID=43063642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/005083 WO2011020610A1 (en) | 2009-08-19 | 2010-08-19 | Drug delivery systems (wafer) for pediatric use |
Country Status (7)
Country | Link |
---|---|
US (1) | US20120207836A1 (en) |
EP (1) | EP2467126A1 (en) |
JP (1) | JP2013502388A (en) |
KR (1) | KR20120056824A (en) |
CN (1) | CN102470101A (en) |
CA (1) | CA2771358A1 (en) |
WO (1) | WO2011020610A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013121663A1 (en) * | 2012-02-14 | 2013-08-22 | 救急薬品工業株式会社 | Intraorally dissolving film preparation |
JP2015512924A (en) * | 2012-04-12 | 2015-04-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | Oral film containing opiate enteric-release beads |
US9822257B2 (en) | 2012-07-23 | 2017-11-21 | Crayola Llc | Dissolvable films and methods of using the same |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014144661A1 (en) * | 2013-03-15 | 2014-09-18 | Aprecia Pharmaceuticals Compny | Rapidly dispersible dosage form of topiramate |
CA2906107C (en) | 2013-03-15 | 2021-08-24 | Aprecia Pharmaceuticals Company | Rapidly dispersible dosage form of oxcarbazepine |
JPWO2016117642A1 (en) * | 2015-01-22 | 2017-10-26 | ニプロ株式会社 | Film formulation |
US20160243036A1 (en) * | 2015-02-25 | 2016-08-25 | Intelgenx Corp. | Film dosage forms containing amorphous active agents |
US20220016074A1 (en) | 2018-11-21 | 2022-01-20 | Rosemont Pharmaceuticals Limited | Oral topiramate suspension formulations with extended shelf stability and enhanced bioavailability |
Citations (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0241178A1 (en) * | 1986-03-25 | 1987-10-14 | Rohto Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating periodontal diseases |
US4800087A (en) | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
WO2000030617A1 (en) | 1998-11-25 | 2000-06-02 | Cima Labs Inc. | Taste masking rapid release coating system |
WO2000042992A2 (en) | 1999-01-21 | 2000-07-27 | Lavipharm Laboratories, Inc. | Compositions and methods for mucosal delivery |
WO2001070194A1 (en) * | 2000-03-23 | 2001-09-27 | Warner-Lambert Company | Fast dissolving orally consumable films containing an ion exchange resin as a taste masking agent |
WO2003030883A1 (en) | 2001-10-12 | 2003-04-17 | Kosmos Pharma | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US20060105038A1 (en) | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
EP1787640A1 (en) | 2004-04-30 | 2007-05-23 | Astellas Pharma Inc. | Time-limited release type granular pharmaceutical composition for oral administration and intraoral rapid disintegration tablet containing the composition |
US20070148230A1 (en) | 2003-12-09 | 2007-06-28 | Keiichi Fujiwara | Medicament-containing particle and a solid preparation containing the particle |
WO2007074472A2 (en) | 2005-12-27 | 2007-07-05 | Jubilant Organosys Limited | Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxide |
WO2007073911A2 (en) | 2005-12-24 | 2007-07-05 | Bayer Technology Services Gmbh | Masking the taste of powders |
US7255876B2 (en) | 2001-07-27 | 2007-08-14 | Astellas Pharma, Inc. | Composition comprises sustained-release fine particles and manufacturing method thereof |
WO2007109057A2 (en) | 2006-03-16 | 2007-09-27 | Novartis Ag | Solid dosage form containing a taste masked active agent |
US20070292479A1 (en) | 2006-01-24 | 2007-12-20 | Hans-Peter Podhaisky | Film-shaped drug forms for use in the oral cavity (wafers) |
WO2008040534A2 (en) | 2006-10-02 | 2008-04-10 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Non-mucoadhesive film dosage forms |
WO2008108940A1 (en) * | 2007-03-05 | 2008-09-12 | Mcneil-Ppc, Inc. | Fast-dissolving/disintegrating film preparation having high proportion of active |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7425292B2 (en) * | 2001-10-12 | 2008-09-16 | Monosol Rx, Llc | Thin film with non-self-aggregating uniform heterogeneity and drug delivery systems made therefrom |
US20040208931A1 (en) * | 2002-12-30 | 2004-10-21 | Friend David R | Fast dissolving films for oral administration of drugs |
BR112012006635B8 (en) * | 2008-09-23 | 2021-05-25 | Laboratory Skin Care Inc | composition comprising uniform, rigid, spherical, nanoporous calcium phosphate micro-sized particles and method for combining and separating the non-aqueous solvent from said particles |
-
2010
- 2010-08-19 EP EP10745182A patent/EP2467126A1/en not_active Withdrawn
- 2010-08-19 JP JP2012525086A patent/JP2013502388A/en active Pending
- 2010-08-19 CA CA2771358A patent/CA2771358A1/en not_active Abandoned
- 2010-08-19 WO PCT/EP2010/005083 patent/WO2011020610A1/en active Application Filing
- 2010-08-19 US US13/391,377 patent/US20120207836A1/en not_active Abandoned
- 2010-08-19 CN CN201080036372XA patent/CN102470101A/en active Pending
- 2010-08-19 KR KR1020127004173A patent/KR20120056824A/en not_active Application Discontinuation
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0241178A1 (en) * | 1986-03-25 | 1987-10-14 | Rohto Pharmaceutical Co., Ltd. | Pharmaceutical composition for treating periodontal diseases |
US4800087A (en) | 1986-11-24 | 1989-01-24 | Mehta Atul M | Taste-masked pharmaceutical compositions |
WO2000030617A1 (en) | 1998-11-25 | 2000-06-02 | Cima Labs Inc. | Taste masking rapid release coating system |
WO2000042992A2 (en) | 1999-01-21 | 2000-07-27 | Lavipharm Laboratories, Inc. | Compositions and methods for mucosal delivery |
WO2001070194A1 (en) * | 2000-03-23 | 2001-09-27 | Warner-Lambert Company | Fast dissolving orally consumable films containing an ion exchange resin as a taste masking agent |
US7255876B2 (en) | 2001-07-27 | 2007-08-14 | Astellas Pharma, Inc. | Composition comprises sustained-release fine particles and manufacturing method thereof |
WO2003030883A1 (en) | 2001-10-12 | 2003-04-17 | Kosmos Pharma | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US20070148230A1 (en) | 2003-12-09 | 2007-06-28 | Keiichi Fujiwara | Medicament-containing particle and a solid preparation containing the particle |
EP1787640A1 (en) | 2004-04-30 | 2007-05-23 | Astellas Pharma Inc. | Time-limited release type granular pharmaceutical composition for oral administration and intraoral rapid disintegration tablet containing the composition |
US20060105038A1 (en) | 2004-11-12 | 2006-05-18 | Eurand Pharmaceuticals Limited | Taste-masked pharmaceutical compositions prepared by coacervation |
WO2006055142A2 (en) | 2004-11-12 | 2006-05-26 | Eurand Pharmaceuticals Limited | Taste-masked multiparticulate pharmaceutical compositions comprising a drug-containing core particle and a solvent-coacervated membrane |
WO2007073911A2 (en) | 2005-12-24 | 2007-07-05 | Bayer Technology Services Gmbh | Masking the taste of powders |
WO2007074472A2 (en) | 2005-12-27 | 2007-07-05 | Jubilant Organosys Limited | Mouth dissolving pharmaceutical composition and process for preparing the same using a high amount of silicon dioxide |
US20070292479A1 (en) | 2006-01-24 | 2007-12-20 | Hans-Peter Podhaisky | Film-shaped drug forms for use in the oral cavity (wafers) |
WO2007109057A2 (en) | 2006-03-16 | 2007-09-27 | Novartis Ag | Solid dosage form containing a taste masked active agent |
WO2008040534A2 (en) | 2006-10-02 | 2008-04-10 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Non-mucoadhesive film dosage forms |
WO2008108940A1 (en) * | 2007-03-05 | 2008-09-12 | Mcneil-Ppc, Inc. | Fast-dissolving/disintegrating film preparation having high proportion of active |
Non-Patent Citations (8)
Title |
---|
A CRAM ET AL., INT J PHARM, vol. 365, 2009, pages 1 - 3 |
E. IMAI; K. SAITO ET AL.: "Effect of Physical Properties of Food Particles on the Degree of Graininess perceived in the Mouth", JOURNAL OF TEXTURE STUDIES, vol. 30, 1999, pages 59 - 88 |
J. BREITKREUTZ ET AL., EXP OPIN DRUG DELIV, vol. 4, 2007, pages 37 - 45 |
J. PRESCOTT ET AL.: "Cross-cultural comparisons of Japanese and Australian responses to manipulation of sweetness in foods", FOOD QUALITY AND PREFERENCE, vol. 8, no. 1, 1997, pages 45 - 55 |
SI PATHER; MJ RATHBONE; S SENEL, EXPERT OPIN DRUG DELIV, 2008, pages 531 |
T. HURLEY ET AL., STEROIDS, vol. 67, 2002, pages 165 - 174 |
VAN D. REIF ET AL., PHARMACEUTICAL RESEARCH, vol. 4, 1987, pages 54 - 58 |
XU ET AL., INTJ PHARM, vol. 359, 2008, pages 63 |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013121663A1 (en) * | 2012-02-14 | 2013-08-22 | 救急薬品工業株式会社 | Intraorally dissolving film preparation |
JPWO2013121663A1 (en) * | 2012-02-14 | 2015-05-11 | 救急薬品工業株式会社 | Oral dissolution type film preparation |
JP2015512924A (en) * | 2012-04-12 | 2015-04-30 | エルテーエス ローマン テラピー−ジステーメ アーゲー | Oral film containing opiate enteric-release beads |
US9822257B2 (en) | 2012-07-23 | 2017-11-21 | Crayola Llc | Dissolvable films and methods of using the same |
Also Published As
Publication number | Publication date |
---|---|
US20120207836A1 (en) | 2012-08-16 |
CA2771358A1 (en) | 2011-02-24 |
EP2467126A1 (en) | 2012-06-27 |
CN102470101A (en) | 2012-05-23 |
KR20120056824A (en) | 2012-06-04 |
JP2013502388A (en) | 2013-01-24 |
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