WO2011013112A2 - Phase behavior analysis using a microfluidic platform - Google Patents
Phase behavior analysis using a microfluidic platform Download PDFInfo
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- WO2011013112A2 WO2011013112A2 PCT/IB2010/053984 IB2010053984W WO2011013112A2 WO 2011013112 A2 WO2011013112 A2 WO 2011013112A2 IB 2010053984 W IB2010053984 W IB 2010053984W WO 2011013112 A2 WO2011013112 A2 WO 2011013112A2
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Classifications
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
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- E21B—EARTH DRILLING, e.g. DEEP DRILLING; OBTAINING OIL, GAS, WATER, SOLUBLE OR MELTABLE MATERIALS OR A SLURRY OF MINERALS FROM WELLS
- E21B49/00—Testing the nature of borehole walls; Formation testing; Methods or apparatus for obtaining samples of soil or well fluids, specially adapted to earth drilling or wells
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Electro-optical investigation, e.g. flow cytometers
- G01N15/1484—Electro-optical investigation, e.g. flow cytometers microstructural devices
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
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Definitions
- This patent specification relates to an apparatus and method for measuring thermo-physical properties of a fluid. More particularly, the patent specification relates to an apparatus and method for analyzing phase behavior properties of a reservoir fluid flowing in a microfluidic device.
- PVT pressure, volume, and temperature measurements
- One important use of PVT measurements is the construction of an equation of state describing the state of oil in the reservoir fluid.
- Other properties of interest include fluid viscosity, density, chemical composition, gas-oil-ratio, and the like.
- a system for analyzing phase properties in a microfluidic device includes a microchannel adapted to carry a fluid and having an entrance passageway and an exit passageway.
- a fluid introduction system in fluid communication with the entrance passageway, introduces the fluid under pressure via the entrance passageway.
- An optical sensing system is adapted and positioned to detect phase states of the fluid at a plurality of locations along the microchannel.
- the optical sensing system preferably includes a processing system adapted and programmed to distinguish gas from liquid phases of fluid in the microchannel at a plurality of locations along the microchannel based on a plurality of digital images of the fluid in the microchannel.
- a plurality of bi-level images are preferably generated based on the digital images of the fluid in the microchannel, and values relating to the fraction of liquid or gas in the fluid is preferably estimated for a plurality of pressures based at least in part on the plurality of bi-level images.
- Properties such as bubble point values and/or a phase volume distribution ratio versus pressure for the fluid are preferably estimated based at least in part on the detected phase states of the fluid.
- a method for analyzing phase properties in a microfluidic device is provided.
- a microchannel adapted to carry a fluid is provided that has an entrance passageway and an exit passageway. Fluid is introduced under pressure into the microchannel via the entrance passageway, and phase states of the fluid are optically detected at a plurality of locations along the microchannel.
- Figure 1 is a stylized, exploded, perspective view of a first illustrative embodiment of a microfluidic device for measuring thermo-physical properties of a reservoir fluid
- Figure 2 is a stylized, schematic representation of a reaction of reservoir fluid as the reservoir fluid flows through the microfluidic device of Figure 1 ;
- Figure 3 is a top, plan view of the microfluidic device of Figure 1 depicting three reservoir fluid flow regimes;
- Figure 4 is a stylized, side, elevational view of a reservoir fluid measurement system, including the microfluidic device of Figure 1 and a camera for generating images of the microfluidic device in use;
- Figure 5 is a top, plan view of a second illustrative embodiment of a microfluidic device for measuring thermo-physical properties of a reservoir fluid
- Figure 6 is a side, elevational view of the microfluidic device of Figure 5;
- Figures 7-9 depict exemplary microchannel constrictions of the microfluidic device of Figure 5;
- Figure 10 is a stylized, schematic representation phase behavior analysis system, according to some embodiments.
- Figure 11 shows an example of a frame of captured video from a fluid flowing through a microfluidic device, according to some embodiments
- Figure 12A is a plot showing pressure drop in a microchannel versus channel length for a mixture of Ci and Cio, according to some embodiments.
- Figure 12B is a plot showing phase volume distribution versus pressure for a mixture of Ci and Cio, according to some embodiments.
- Figure 13A is a plot showing pressure drop in a microchannel versus channel length for a mixture of a multicomponent gas and Cio, according to some embodiments;
- Figure 13B is a plot showing phase volume distribution versus pressure for a mixture of a multicomponent gas and C10, according to some embodiments;
- Figure 14A is a plot showing pressure drop in a microchannel versus channel length for a mixture of a light oil and Ci, according to some embodiments.
- Figure 14B is a plot showing phase volume distribution versus pressure for a mixture of a light oil and Ci, according to some embodiments.
- Figure 15 shows an example of a line-scan method for measuring the liquid fraction in a microfluidic device, according to some other embodiments
- Figure 16 shows an example of a matrix of phase states, according to some embodiments.
- Figures 17A and 17B are plots showing the results of the line scan videos, according to some embodiments.
- Figures 18A and 18B show a microchannel according to an alternative embodiment
- Figure 19 shows an example of a spiral microchannel layout pattern, according to an alternative embodiment.
- techniques for measuring phase behavior of gas-liquid mixtures are provided.
- the techniques use a microfabricated chip made of a microchannel connected to thin Silicone membranes that deform under the fluid pressure.
- the pressure inside the channel is measured using the membranes as further described in co-pending U.S. Patent Application No. 12/533,292, Patent Application Publication No. US 2010/0017135, entitled “PRESSURE MEASUREMENT OF A RESERVOIR FLUID IN A MICROFLUIDIC DEVICE,” Attorney Docket Number 117.0037 US NP, filed on even date herewith, which is incorporated by reference herein.
- the liquid fraction along the channel is measured by capturing videos of the flow and processing them with a Matlab program.
- a phase behavior curve is obtained by plotting the liquid fraction against the pressure.
- reservoir fluid means a fluid stored in or transmitted from a subsurface body of permeable rock.
- reservoir fluid may include, without limitation, hydrocarbon fluids, saline fluids such as saline water, as well as other formation water, and other fluids such as carbon dioxide in a supercritical phase.
- microfluidic means having a fluid-carrying channel exhibiting a width within a range of a few to hundreds of micrometers, but exhibiting a length that is many times longer than the width of the channel.
- microchannel means a fluid-carrying channel exhibiting a width within a range of a few to hundreds of micrometers.
- the cross section of a microchannel can be of any shape, including round, oval, ellipsoid, square, etc.
- FIG. 1 depicts a stylized, exploded, perspective view of a microfluidic device 101 for studying phase behavior, according to some embodiments of the invention.
- microfluidic device 101 comprises a first substrate 103 defining a microchannel 105, an entrance well 107 and an exit well 109.
- MicroChannel 105 extends between and is in fluid communication with entrance well 107 and exit well 109.
- MicroChannel 105 forms a serpentine pattern in first substrate 103, thus allowing microchannel 105 to extend a significant length but occupy a relatively small area.
- microchannel 105 exhibits a length of one or more meters, a width of about 100 micrometers, and a depth of about 50 micrometers, although the present invention also contemplates other dimensions for microchannel 105.
- Microfluidic device 101 further comprises a second substrate 111 having a lower surface 113 that is bonded to an upper surface 115 of first substrate 103. When second substrate 111 is bonded to first substrate 103, microchannel 105 is sealed except for an inlet 117 at entrance well 107 and an outlet 119 at exit well 109. Second substrate 111 defines an entrance passageway 121 and an exit passageway 123 therethrough, which are in fluid communication with entrance well 107 and exit well 109, respectively, of first substrate 103. Also shown in Fig.
- each cavity such as cavity 150 is partially defined by a deformable membrane that allows for pressure measurement.
- substrate 103 is fabricated with circular openings and the cavities are defined on the sides by the walls of the openings in substrate 103, on the bottom with the deformable membrane, and on the top by the second substrate 111.
- first substrate 103 is preferably made of silicon and is approximately 500 micrometers thick
- second substrate 11 1 is made of glass, such as borosilicate glass, although the present invention contemplates other materials for first substrate 103, as is discussed in greater detail herein.
- substrate 103 is a conventional silicon on insulator (SOI) wafer.
- SOI silicon on insulator
- Exemplary borosilicate glasses are manufactured by Schott North America, Inc. of Elmsford, New York, USA, and by Corning Incorporated of Corning, New York, USA.
- pressurized reservoir fluid is urged through entrance passageway 121 , entrance well 107, and inlet 117 into microchannel 105.
- the reservoir fluid exits microchannel 105 through outlet 119, exit well 109, and exit passageway 123.
- MicroChannel 105 provides substantial resistance to the flow of reservoir fluid therethrough because microchannel 105 is very small in cross-section in relation to the length of microchannel 105.
- an input pressure e.g., reservoir pressure
- an output pressure e.g., atmospheric pressure
- the flow rate is a function of the overall pressure drop between inlet 117 and outlet 119, and viscosity. Fluid flow through microchannel 105 is laminar and, thus the pressure drop between inlet 117 and outlet 119 is linear when the reservoir fluid exhibits single-phase flow.
- PCT/IB09/50500 filed February 7, 2009, which is incorporated by reference herein.
- Figure 2 provides a stylized, schematic representation of the reaction of reservoir fluid 201 as the reservoir fluid flows through microchannel 105 in a direction generally corresponding to arrow 202, according to some embodiments.
- the reservoir fluid enters inlet 117 of microchannel 105, the reservoir fluid is at a pressure above the "bubble point pressure" of the reservoir fluid.
- the bubble point pressure of a fluid is the pressure at or below which the fluid begins to boil, i.e., bubble, at a given temperature.
- the reservoir fluid exits outlet 119 of microchannel 105 the reservoir fluid is at a pressure below the bubble point pressure of the reservoir fluid.
- a "first" bubble 203 forms in the reservoir fluid at some location, e.g., at 205 in Figure 2, within microchannel 105 where the reservoir fluid is at the bubble point pressure.
- multi-phase flow e.g., gas and liquid flow
- of reservoir fluid 201 occurs in microchannel 105.
- Previously-formed bubbles e.g. bubbles 207, 209, 211 , 213, 215, and the like, grow in size as reservoir fluid 201 flows within microchannel 105 beyond the location corresponding to the formation of the first bubble due to decreased pressure in this portion of microchannel 105 and more evaporation of the lighter components of reservoir fluid 201.
- the bubbles are separated by slugs of liquid, such as slugs 217, 219, 221 , 223, 225, and the like. Expansion of the bubbles, such as bubbles 207, 209, 211 , 213, 215, results in an increased flow velocity of the bubbles and liquid slugs, such as slugs 217, 219, 221 , 223, 225, within microchannel 105.
- the mass flow rate of reservoir fluid 201 is substantially constant along microchannel 105; however, the volume flow rate of reservoir fluid 201 increases as reservoir fluid flows along microchannel 105.
- the reservoir fluid also enters cavity 150 through small channel 152. According to some embodiments the width of small side channel 152 is approximately 50 micrometers, or about half of the width of microchannel 105, and is about 50 micrometers deep.
- Thermo-physical properties of the reservoir fluid can be determined by measuring the size and concentration of bubbles within microchannel 105.
- a first bubble such as first bubble 203 of Figure 2
- the pressure of the reservoir fluid is above the bubble point. No bubbles are observed within first region 303.
- first region 303 the flow of the reservoir fluid is laminar due to a low Reynolds number and the pressure drops linearly therein. Once bubbles are formed, the bubbles move along within microchannel 105 toward outlet 119 and the volumes of the bubbles increases.
- the void fraction i.e., the volume of gas to total volume, of the reservoir fluid is less than one.
- a third region 307 the flow of the reservoir fluid is dominated by high-speed gas flow. The gas bubbles are separated by small droplets of liquid, such as water. The pressure of the reservoir fluid within third region 307 decreases rapidly. Gas bubbles flow within second region 305 at a slower rate than in third region 307, where they are often nearly impossible to follow with the naked eye.
- a camera 401 is used to capture snapshots of the flow, as shown in Figure 4. Note that the flow of reservoir fluid into inlet 1 17 (shown in Figures 1 and 3) is represented by an arrow 403 and that the flow of reservoir fluid from outlet 119 (shown in Figures 1 and 3) is represented by an arrow 405.
- camera 401 is a charge- coupled device (CCD) type camera.
- image analysis software such as ImageJ 1.38x, available from the United States National Institutes of Health, of Bethesda, Maryland, USA, and ProAnalyst, available from Xcitex, Inc.
- FIGS 5 and 6 depict a microfluidic device 501 , according to some embodiments.
- microfluidic device 501 comprises a first substrate 503 defining a microchannel 505, an entrance well 507, and an exit well 509.
- MicroChannel 505 extends between and is in fluid communication with entrance well 507 and exit well 509.
- first substrate 503 is made from silicon; however, first substrate 503 may be made from glass.
- MicroChannel 505, entrance well 507, and exit well 509 are, in one embodiment, first patterned onto first substrate 503 using a photolithography technique and then etched into first substrate 503 using a deep reactive ion etching technique.
- microchannel 505 exhibits a length of one or more meters, a width of about 100 micrometers, and a depth of about 50 micrometers, although the present invention also contemplates other dimensions for microchannel 505.
- a number small side channels, such as side channels 552 and 556 lead from the main microchannel 505 to circular cavities such as cavities 550 and 554. Also shown in a side channel 560 that leads to cavity 558.
- each of the cavities are about 2mm in diameter, although the present invention also contemplates other numbers of cavities and diameters for each cavity.
- Each cavity is partially defined by a flexible membrane on the under side of the device 501. The membranes deform under the local static pressure. The deformation is measured using a Confocal Polychromatic Sensor (CCS), and after calibration, gives the pressure value inside the channel.
- CCS Confocal Polychromatic Sensor
- Microfluidic device 501 further comprises a second substrate 511 defining an entrance passageway 513 and an exit passageway 515 in fluid communication with entrance well 507 and exit well 509.
- Second substrate 511 is made from glass, as discussed herein concerning second substrate 111 (shown in Figure 1 ). By making the front of the device 501 transparent, observation of the flow and video capturing of the flow inside the microchannel 505 is provided.
- entrance passageway 513 and exit passageway 515 are generated in second substrate 511 using a water jet or abrasive water jet technique.
- First substrate 503 and second substrate 511 are preferably fused using an anodic bonding method after careful cleaning of the bonding surfaces of substrates 503 and 511.
- microfluidic device 501 having any suitable size and/or shape needed for a particular implementation.
- microfluidic device 501 exhibits an overall length A of about 80 millimeters and an overall width B of about 15 millimeters.
- passageways 513 and 515 are spaced apart a distance C of about 72 millimeters
- cavities 558 and 550 are spaced apart a distance D of about 3 millimeters
- cavities along the serpentine section of microchannel 505, such as cavities 550 and 554 are spaced apart by a distance E of about 5 millimeters.
- microfluidic device 101 may also exhibit dimensions corresponding to microfluidic device 501. However, the scope of the present invention is not so limited.
- micro-venturi 701 is incorporated into an inlet of microchannel 505.
- Micro-venturi 701 includes a nozzle opening 801 having a width W 1 , which is smaller than a width W 2 of microchannel 505.
- the contraction provided by micro-venturi 701 causes a substantial pressure drop in the reservoir fluid at nozzle opening 801 along with an increased velocity of reservoir fluid flow. The combined effect of the pressure drop and the increased velocity induces formation of bubble nuclei in the reservoir fluid.
- microchannel 505 further includes one or more additional constrictions 703, as shown in Figures 7 and 9.
- Constrictions 703 exhibit widths W 3 , which are smaller than a width W 4 of microchannel 505.
- width W 1 of nozzle opening 801 and widths W 3 of constrictions 703 are about 20 micrometers, whereas the preferred width W 2 and W 4 of microchannel 505 is 100 micrometers. These restrictions increase the velocity of the reservoir fluid by up to about 500 percent.
- Figure 10 is a stylized, schematic representation phase behavior analysis system, according to some embodiments.
- a high capacity syringe 1054 pump electronically controlled by computer system 1030 and pushes a testing fluid stored under pressure in sample bottle 1052.
- the fluid is flowed from sample bottle 1052, through valve 1050 and into the serpentine channel of microfluidic device 501.
- a constant input pressure is maintained, and measured with a pressure gauge 1056.
- a strong light 1062 illuminates the transparent face 511 of the microfluidic device 501 and a camera 1060 captures videos of the flow inside the microchannel. When gas bubbles and liquid slugs are present in the same time in the channel there is a strong difference in brightness between these two phases.
- the images captured by the camera 1060 provide then the distribution of slugs and bubbles along the flow.
- the optical sensor 1010 is mounted on a high-precision stage 1014.
- the optical sensor 1010 moves along the back face of the microfluidic device 501 and measures the deformation of the membrane for each cavity on device 501.
- a spectrometer 1020 receives signals from the optical sensor 1010 via optical fiber link 1012. The results of the spectrometer are fed to the computer system 1030, thus giving a record of the pressure inside the channel at the locations of the cavities on device 501.
- Computer system 1030 includes a one or more processors, a storage system 1032 (which includes one or more removable storage devices that accept computer readable media), display 1036, and one or more human input devices 1034, such as a keyboard and/or a mouse.
- Computer system 1030 also includes a data acquisition system for collecting data from the spectrometer 1020.
- the videos from camera 1060 are stored on computer system 1030 using a video acquisition program, such as is available from EPIX, Inc. of USA. According to some embodiments, a video of the full image of the microchannel is made of approximately 300 frames. According to some embodiments, the controller of pump 1054, the pressure gauge 1056, the stage 1014 and the optical sensor 1012 are all in communication with a control application on computer system 1030 such as the LabVIEW program from National Instruments Corporation, which controls all the devices and records the measurements. [0049] Figure 11 shows an example of a frame of captured video from a fluid flowing through a microfluidic device, according to some embodiments.
- a measurement is made up of one or more videos of the flow plus the measured pressure values at the different cavities of the microfluidic device using the optical sensor.
- Frame 1102 is a frame from a captured video of the flow
- frame 1104 is an image resulting from its transformation into a binary, or black and white image.
- binary image or "bi-level image” means a digital image that has only two possible values for each pixel.
- An image processing routine running on computer system 1030 transforms the original grayscale images such as 1102 into binary images such as 1104.
- the process involves the sensible choice of some image processing parameters.
- the binary image itself is then analyzed by a computation routine, for example also programmed under Matlab.
- the output of the computation is the liquid fraction in each of the segments composing the microchannel. This liquid fraction is then averaged on all the frames of the captured video, thus giving a more precise measurement and a value of the standard deviation. This process thus provides the evolution of the liquid fraction along the channel.
- Figure 12A is a plot showing pressure drop in a microchannel versus channel length for Ci and Cio, according to some embodiments.
- Figure 12B is a plot showing phase volume distribution versus pressure for a mixture of Ci and Ci 0 , according to some embodiments.
- Figures 12A and 12B depict results of the measurements conducted on a live fluid in the microfluidic device shown in Fig. 5 and the setup shown in Fig. 10.
- the fluid is a mixture of methane and decane saturated at 500 psig.
- the pressure measurements of curve 1210 show a linear pressure drop inside the device.
- Combining the pressure measurements with phase volume distribution inside the channel provides the phase volume distribution of the fluid at different pressures as shown in Figure 12B.
- the round circles, such as point 1212 depict the measurements using the microfluidic device in the setup shown in Figure 10, while the solid squares, such as point 1214, show the measurements conducted by a conventional PVT apparatus.
- Figure 13A is a plot showing pressure drop in a microchannel versus channel length for a mixture of a multicomponent gas and C 10 , according to some embodiments.
- Figure 13B is a plot showing phase volume distribution versus pressure for a multicomponent gas and Cio, according to some embodiments.
- the pressure measurements of curve 1310 show a linear pressure drop inside the device.
- the round circles, such as point 1312 depict the measurements using the microfluidic device in the setup shown in Figure 10, while the solid squares, such as point 1314, show the measurements conducted by a conventional PVT apparatus.
- Figure 14A is a plot showing pressure drop in a microchannel versus channel length for a mixture of a light oil and Ci, according to some embodiments.
- Figure 14B is a plot showing phase volume distribution versus pressure for a light oil and Ci, according to some embodiments.
- Figures 14A and 14B shows the results of measurements on a light oil recombined with methane at 500psig saturation pressure.
- the pressure measurements of curve 1410 show a linear pressure drop inside the device.
- the round circles, such as point 1412 depict the measurements using the microfluidic device in the setup shown in Figure 10, while the solid squares, such as point 1414, show the measurements conducted by a conventional PVT apparatus.
- Figures 12B, 13B and 14B there is good agreement between measurements with the microfluidic device and conventional PVT.
- Figure 15 shows an example of a line-scan method for measuring the liquid fraction in a microfluidic device, according to some other embodiments.
- the camera such as camera 1060 of Figure 10, can be set up to capture only a selected line in the image of the channel. In a way, the camera is working in a similar fashion as a barcode reader.
- Each frame highlighted in with the dashed rectangle, is essentially a line that regroups the phase states at the same position in all the segments of the serpentine microchannel.
- phase state can be either liquid, in which case the point corresponding to the segment in the line is bright (and is assigned a value of 1 ), or gas in which case the same point is dark (and is assigned a value of 0).
- a simplified example of the assigned values resulting from a single frame is shown as the binary string 1510.
- Each measured line is at first a grayscale image then undergoes the same image processing as described above with respect to Figure 11. A similar computation gives then the phase state (0 or 1 ) at the line position for each segment in the processed frame. Finally, this binary value is averaged on all the video frames to have the liquid fraction along the channel.
- This line-scan technique allows the capturing of approximately 20,000 frames, improving thus the averaging on the video frames and reducing the error.
- an array of optical fibers connected an array of photo diodes is used instead of a conventional camera. Each optical fiber in the array is directed to a single vertical segment of the serpentine microchannel 505.
- Figure 16 shows an example of a matrix of phase states, according to some embodiments.
- the frames of the line scan video as described with respect to Figure 15, after being converted to a binary image, can be put in a vertical sequence so as to form a matrix 1610.
- the obtained matrix 1610 displays the phase state in all the segments at all the instants of the video.
- the Y-axis is time and moves forward downward-the frame period separates two lines.
- the X-axis is segment number as it comes in the full image.
- the microchannel input is on the left, and the output is on the right. This representation constitutes a type of "fingerprint" that is specific to the flow in the channel and gives valuable information on it, as the frequency that can be observed in the matrix.
- Figures 17A and 17B are plots showing the results of the line scan videos, according to some embodiments.
- the line scan technique gives liquid fraction measurements very close to those obtained with the full image video.
- the liquid fraction is plotted against the pressure profile in the channel and the obtained curve matches the conventional measurements one more time.
- Figure 17A the result of line scan measurements on a methan-decane mixture saturated at 500psig are shown in the solid squares, such as point 1710, and the conventionally measured data is shown in the open triangles, such as point 1712.
- Figure 17B the result of line scan measurements on a multicomponent gas saturated at 600psig with decane are shown in the open circles, such as point 1720, and the conventionally measured data is shown in the solid squares such as point 1722.
- Figures 18A and 18B show a microchannel according to an alternative embodiment.
- the microchannel 1805 is made from a glass tube formed in a serpentine shape.
- Figure 18B shows a cross section of the glass tube microchannel, which is round.
- layout patterns of the microchannel other than serpentine can be used the microfluidic devices.
- Figure 19 shows an example of a spiral microchannel layout pattern, according to an alternative embodiment.
- MicroChannel 1905 can be fabricated with conventional silicon processing or can be made using other techniques, for example it could be a glass tube as shown in Figure 18A and 18B.
- analysis of one or more types of biomedical fluids including but not limited to bodily fluids such as blood, urine, serum, mucus, and saliva.
- analysis of one or more fluids is provided in relation to environmental monitoring, including by not limited to water purification, water quality, and waste water processing, and potable water and/or sea water processing and/or analysis.
- analysis of other fluid chemical compositions is provided.
Abstract
Description
Claims
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AU2010277148A AU2010277148B2 (en) | 2009-07-31 | 2010-09-03 | Phase behavior analysis using a microfluidic platform |
EP10760435.7A EP2460004B1 (en) | 2009-07-31 | 2010-09-03 | Phase behavior analysis using a microfluidic platform |
CN2010800429765A CN102753971A (en) | 2010-09-03 | 2010-09-03 | Phase behavior analysis using a microfluidic platform |
RU2012107538/03A RU2537454C2 (en) | 2009-07-31 | 2010-09-03 | Analysis of phase behaviour using microfluidic platform |
BR112012002237A BR112012002237A2 (en) | 2009-07-31 | 2010-09-03 | system for analyzing phase properties in a microfluidic device, and method for analyzing phase properties in a microfluidic device |
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