WO2011012659A3 - Diethyl 4-(4-fluorobenzylamino)-1,2-phenylenedicarbamate, and salts thereof - Google Patents

Diethyl 4-(4-fluorobenzylamino)-1,2-phenylenedicarbamate, and salts thereof Download PDF

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Publication number
WO2011012659A3
WO2011012659A3 PCT/EP2010/060981 EP2010060981W WO2011012659A3 WO 2011012659 A3 WO2011012659 A3 WO 2011012659A3 EP 2010060981 W EP2010060981 W EP 2010060981W WO 2011012659 A3 WO2011012659 A3 WO 2011012659A3
Authority
WO
WIPO (PCT)
Prior art keywords
salts
phenylenedicarbamate
fluorobenzylamino
diethyl
disclosed
Prior art date
Application number
PCT/EP2010/060981
Other languages
French (fr)
Other versions
WO2011012659A2 (en
Inventor
Judit Serra Miralles
Ernesto Duran Lopez
Jordi Bosch I Lladó
Original Assignee
Medichem S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medichem S.A. filed Critical Medichem S.A.
Publication of WO2011012659A2 publication Critical patent/WO2011012659A2/en
Publication of WO2011012659A3 publication Critical patent/WO2011012659A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
    • C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants

Abstract

Disclosed are diethyl 4-(4-fluorobenzylamino)-l,2-phenylenedicarbamate (IV) and salts thereof, which are useful as reference markers and reference standards for analyzing samples comprising retigabine or salts thereof. Also disclosed is a process for preparing a compound (IV) and salts thereof.
PCT/EP2010/060981 2009-07-28 2010-07-28 Diethyl 4-(4-fluorobenzylamino)-1,2-phenylenedicarbamate, and salts thereof WO2011012659A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22913809P 2009-07-28 2009-07-28
US61/229,138 2009-07-28

Publications (2)

Publication Number Publication Date
WO2011012659A2 WO2011012659A2 (en) 2011-02-03
WO2011012659A3 true WO2011012659A3 (en) 2011-03-31

Family

ID=43247602

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/060981 WO2011012659A2 (en) 2009-07-28 2010-07-28 Diethyl 4-(4-fluorobenzylamino)-1,2-phenylenedicarbamate, and salts thereof

Country Status (1)

Country Link
WO (1) WO2011012659A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9102593B2 (en) 2011-01-18 2015-08-11 Glaxo Group Limited Process for the preparation of retigabine
WO2013011518A1 (en) 2011-07-21 2013-01-24 Arch Pharmalabs Limited Process for the preparation of retigabine of the formula i and pharmaceutically acceptable salts thereof
CN103073455B (en) * 2011-10-25 2015-08-19 中国科学院上海药物研究所 Kcnq potassium channel agonist, Preparation Method And The Use that one class is novel
CN102964273B (en) * 2012-12-06 2014-04-02 北京英科博雅科技有限公司 Novel retigabine crystal form F and preparation method thereof
US10802000B2 (en) 2013-03-15 2020-10-13 Dionex Corporation Method of calibrating a chromatography system
CN103193657B (en) * 2013-04-16 2015-08-05 石家庄度恩医药科技有限公司 A kind of method of synthesizing ezogabine intermediate
CN105017085B (en) * 2014-04-28 2018-06-29 中国科学院上海药物研究所 A kind of kcnq potassium channel agonist, preparation method and use
US9804136B2 (en) 2014-09-18 2017-10-31 Dionex Corporation Automated method of calibrating a chromatography system and analysis of a sample
WO2016077724A1 (en) 2014-11-13 2016-05-19 University Of Pittsburgh - Of The Commonwealth System Of Higher Education (2-amino-4(arylamino)phenyl) carbamates

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384330A (en) * 1992-01-08 1995-01-24 Asta Medica Aktiengesellschaft Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes for their preparation and pharmaceutical compositions containing them
US20030023111A1 (en) * 2001-07-25 2003-01-30 Hans-Joachim Lankau Process for the production of 1,2,4-triaminobenzene carbamic acid esters

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5384330A (en) * 1992-01-08 1995-01-24 Asta Medica Aktiengesellschaft Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes for their preparation and pharmaceutical compositions containing them
US20030023111A1 (en) * 2001-07-25 2003-01-30 Hans-Joachim Lankau Process for the production of 1,2,4-triaminobenzene carbamic acid esters

Also Published As

Publication number Publication date
WO2011012659A2 (en) 2011-02-03

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