WO2011007038A3 - Use of compounds derived from bis-benzamidines as fluorogenic agents for signalling specific sequencecs of double-strand dna, and novel compounds - Google Patents

Use of compounds derived from bis-benzamidines as fluorogenic agents for signalling specific sequencecs of double-strand dna, and novel compounds Download PDF

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Publication number
WO2011007038A3
WO2011007038A3 PCT/ES2010/070486 ES2010070486W WO2011007038A3 WO 2011007038 A3 WO2011007038 A3 WO 2011007038A3 ES 2010070486 W ES2010070486 W ES 2010070486W WO 2011007038 A3 WO2011007038 A3 WO 2011007038A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
benzamidines
bis
double
sequencecs
Prior art date
Application number
PCT/ES2010/070486
Other languages
Spanish (es)
French (fr)
Other versions
WO2011007038A2 (en
Inventor
Olalla Vazquez
Mateo Isidro Lopez
Eugenio Vazquez Sentis
Jose Luis MASCAREÑAS
Original Assignee
Universidade De Santiago De Compostela
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from ES200930462A external-priority patent/ES2351652B1/en
Priority claimed from ES200930461A external-priority patent/ES2355031B2/en
Application filed by Universidade De Santiago De Compostela filed Critical Universidade De Santiago De Compostela
Publication of WO2011007038A2 publication Critical patent/WO2011007038A2/en
Publication of WO2011007038A3 publication Critical patent/WO2011007038A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Abstract

The invention relates to the use of compounds derived from bis-benzamidines as fluorogenic agents for signalling specific sequences of double-strand DNA and to novel compounds. More specifically, the invention relates to the use of compounds derived from propamidine-pentamidine and containing 4-aminobenzamidine groups as fluorogenic DNA-sequence-recognition agents since they can bind to the DNA minor groove, and to novel compounds.
PCT/ES2010/070486 2009-07-15 2010-07-13 Use of compounds derived from bis-benzamidines as fluorogenic agents for signalling specific sequencecs of double-strand dna, and novel compounds WO2011007038A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
ES200930462A ES2351652B1 (en) 2009-07-15 2009-07-15 USE OF COMPOUNDS DERIVED FROM BIS-BENZAMIDES AS FLUOROGENIC AGENTS TO SIGNAL SPECIFIC SEQUENCES OF DOUBLE-CHAIN DNA.
ESP200930462 2009-07-15
ES200930461A ES2355031B2 (en) 2009-07-15 2009-07-15 DERIVATIVES OF BIS-BENZAMIDINES AND ITS USE AS AGENCIES OF RECOGNITION OF DNA SEQUENCES.
ESP200930461 2009-07-15

Publications (2)

Publication Number Publication Date
WO2011007038A2 WO2011007038A2 (en) 2011-01-20
WO2011007038A3 true WO2011007038A3 (en) 2011-03-10

Family

ID=43449892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2010/070486 WO2011007038A2 (en) 2009-07-15 2010-07-13 Use of compounds derived from bis-benzamidines as fluorogenic agents for signalling specific sequencecs of double-strand dna, and novel compounds

Country Status (1)

Country Link
WO (1) WO2011007038A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2396076B2 (en) * 2011-08-24 2013-12-05 Universidade De Santiago De Compostela INTERNALIZATION AND PHOTOCONTROLLED ACTIVATION OF SMALL MOLECULES CAPABLE OF BINDING THE DNA OF DOUBLE FEMALE.
ES2527255B2 (en) * 2013-06-20 2015-06-09 Universidade De Santiago De Compostela Fluorescent compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096609A1 (en) * 2000-06-14 2001-12-20 The Scripps Research Institute Method for screening dna binding
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001096609A1 (en) * 2000-06-14 2001-12-20 The Scripps Research Institute Method for screening dna binding
WO2002002516A2 (en) * 2000-06-30 2002-01-10 Thomas Jefferson University Inhibitors of hiv integrase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
BAILLY, C. ET AL.: "Sequence-selective binding to DNA of bis(amidinophenoxy)alkanes related to propamidine and pentamidine", BIOCHEMICAL JOURNAL, vol. 323, 1997, pages 23 - 31 *
HANNON, M.J.: "Supramolecular DNA recognition", CHEMICAL SOCIETY REVIEWS, vol. 36, 2007, pages 280 - 295 *
MENEZES, F.A.S. ET AL.: "3D-WHIM Pattern Recognition Study for Bisamidines. A Structure-Property Relationship Study.", JOURNAL OF BRAZILIAN CHEMICAL SOCIETY, vol. 11, no. 4, 2000, pages 393 - 397 *
VAZQUEZ, O. ET AL.: "Bis-4-aminobenzamidines: Versatile, Fluorogenic A/T-Selective dsDNA Binders", ORGANIC LETTERS, vol. 12, no. 2, 2010, pages 216 - 219, XP055204419, DOI: doi:10.1021/ol902501j *

Also Published As

Publication number Publication date
WO2011007038A2 (en) 2011-01-20

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