WO2011002814A3 - Sulfonamido - biphenyloxyacetic acid compounds - Google Patents

Sulfonamido - biphenyloxyacetic acid compounds Download PDF

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Publication number
WO2011002814A3
WO2011002814A3 PCT/US2010/040482 US2010040482W WO2011002814A3 WO 2011002814 A3 WO2011002814 A3 WO 2011002814A3 US 2010040482 W US2010040482 W US 2010040482W WO 2011002814 A3 WO2011002814 A3 WO 2011002814A3
Authority
WO
WIPO (PCT)
Prior art keywords
sulfonamido
acid compounds
general formula
biphenyloxyacetic
biphenyloxyacetic acid
Prior art date
Application number
PCT/US2010/040482
Other languages
French (fr)
Other versions
WO2011002814A2 (en
Inventor
Brian F. Mcguinness
Koc-Kan Ho
Suresh Babu
Guizhen Dong
Jingqi Duo
Thuy X. H. Le
Kurt W. Saionz
Michael J. Neeb
Original Assignee
Ligand Pharmaceuticals Inc.
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ligand Pharmaceuticals Inc., Smithkline Beecham Corporation filed Critical Ligand Pharmaceuticals Inc.
Publication of WO2011002814A2 publication Critical patent/WO2011002814A2/en
Publication of WO2011002814A3 publication Critical patent/WO2011002814A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00Sulfones; Sulfoxides
    • C07C317/26Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton

Abstract

Some embodiments of the present invention include novel phenoxyacetic acids useful for the prevention and treatment of inflammatory disorders, including those affecting the respiratory system and skin. Some compounds provided include those of the general formula (I), and compounds of general formula (Ia).
PCT/US2010/040482 2009-06-30 2010-06-29 Biaryl oxyacetic acid compounds WO2011002814A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22189909P 2009-06-30 2009-06-30
US61/221,899 2009-06-30

Publications (2)

Publication Number Publication Date
WO2011002814A2 WO2011002814A2 (en) 2011-01-06
WO2011002814A3 true WO2011002814A3 (en) 2011-05-26

Family

ID=43067187

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/040482 WO2011002814A2 (en) 2009-06-30 2010-06-29 Biaryl oxyacetic acid compounds

Country Status (1)

Country Link
WO (1) WO2011002814A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2013104506A (en) 2010-07-05 2014-08-10 Актелион Фармасьютиклз Лтд 1-Phenyl-substituted heterocyclyl derivatives and their use as modulators of the prostaglandin receptor D2
EP2794563B1 (en) 2011-12-21 2017-02-22 Actelion Pharmaceuticals Ltd Heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators
EP2885307A1 (en) 2012-07-05 2015-06-24 Actelion Pharmaceuticals Ltd. 1-phenyl-substituted heterocyclyl derivatives and their use as prostaglandin d2 receptor modulators

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000762A2 (en) * 2002-06-20 2003-12-31 Smithkline Beecham Corporation Propionic acid derivatives and their use as hppars activators
WO2004058164A2 (en) * 2002-12-20 2004-07-15 Tularik, Inc. Asthma and allergic inflammation modulators
WO2005105727A1 (en) * 2004-05-04 2005-11-10 Novartis Ag Crth2 receptor antagonists
WO2010102154A2 (en) * 2009-03-05 2010-09-10 Ligand Pharmaceuticals Incorporated Biaryl oxyacetic acid compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005102338A1 (en) 2004-04-20 2005-11-03 Pfizer Limited Method of treating neuropathic pain using a crth2 receptor antagonist

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004000762A2 (en) * 2002-06-20 2003-12-31 Smithkline Beecham Corporation Propionic acid derivatives and their use as hppars activators
WO2004058164A2 (en) * 2002-12-20 2004-07-15 Tularik, Inc. Asthma and allergic inflammation modulators
WO2005105727A1 (en) * 2004-05-04 2005-11-10 Novartis Ag Crth2 receptor antagonists
WO2010102154A2 (en) * 2009-03-05 2010-09-10 Ligand Pharmaceuticals Incorporated Biaryl oxyacetic acid compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MAIS D ET AL: "Thromboxane A2 receptor antagonists. Synthesis and activities of phenylsulfonamido derivatives", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, EDITIONS SCIENTIFIQUE ELSEVIER, PARIS, FR, vol. 26, no. 8, 1 November 1991 (1991-11-01), pages 821 - 827, XP023870492, ISSN: 0223-5234, [retrieved on 19911101], DOI: DOI:10.1016/0223-5234(91)90009-C *

Also Published As

Publication number Publication date
WO2011002814A2 (en) 2011-01-06

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