WO2011000811A3 - Pharmaceutical solutions for infusion - Google Patents

Pharmaceutical solutions for infusion Download PDF

Info

Publication number
WO2011000811A3
WO2011000811A3 PCT/EP2010/059164 EP2010059164W WO2011000811A3 WO 2011000811 A3 WO2011000811 A3 WO 2011000811A3 EP 2010059164 W EP2010059164 W EP 2010059164W WO 2011000811 A3 WO2011000811 A3 WO 2011000811A3
Authority
WO
WIPO (PCT)
Prior art keywords
infusion
pharmaceutical solutions
staurosporine
benzoyl
surfactant
Prior art date
Application number
PCT/EP2010/059164
Other languages
French (fr)
Other versions
WO2011000811A4 (en
WO2011000811A2 (en
Inventor
Markus Ahlheim
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of WO2011000811A2 publication Critical patent/WO2011000811A2/en
Publication of WO2011000811A3 publication Critical patent/WO2011000811A3/en
Publication of WO2011000811A4 publication Critical patent/WO2011000811A4/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

A pharmaceutical composition for infusion comprising (a) N-benzoyl-staurosporine, (b) an organic solvent selected from the group of ethanol, propylene glycol and polyethylene glycol having an average molecular weight of 200 to 600 g/mol, and (c) a surfactant.
PCT/EP2010/059164 2009-06-30 2010-06-29 Organic compounds WO2011000811A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09164125 2009-06-30
EP09164125.8 2009-06-30

Publications (3)

Publication Number Publication Date
WO2011000811A2 WO2011000811A2 (en) 2011-01-06
WO2011000811A3 true WO2011000811A3 (en) 2011-05-05
WO2011000811A4 WO2011000811A4 (en) 2011-07-21

Family

ID=42064268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/059164 WO2011000811A2 (en) 2009-06-30 2010-06-29 Organic compounds

Country Status (1)

Country Link
WO (1) WO2011000811A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013171763A1 (en) 2012-04-27 2013-11-21 Sun Pharmaceutical Industries Ltd Ready to be infused gemcitabine solution

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
WO1995022331A1 (en) * 1994-02-18 1995-08-24 Cephalon, Inc. Aqueous indolocarbazole solutions
EP0733372A2 (en) * 1995-03-21 1996-09-25 Ciba-Geigy Ag Pharmaceutical base for the formulation of nanosuspensions
EP0797978A2 (en) * 1996-03-29 1997-10-01 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent comprising a specific inhibitor of protein kinase C
WO2000048571A1 (en) * 1999-02-16 2000-08-24 Novartis Ag Spontaneously dispersible n-benzoyl staurosporine compositions
WO2002076432A2 (en) * 2001-03-26 2002-10-03 Novartis Ag Pharmaceutical composition comprising a poorly water-soluble active ingredient, a surfactant and a water-soluble polymer

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5093330A (en) * 1987-06-15 1992-03-03 Ciba-Geigy Corporation Staurosporine derivatives substituted at methylamino nitrogen
WO1995022331A1 (en) * 1994-02-18 1995-08-24 Cephalon, Inc. Aqueous indolocarbazole solutions
EP0733372A2 (en) * 1995-03-21 1996-09-25 Ciba-Geigy Ag Pharmaceutical base for the formulation of nanosuspensions
EP0797978A2 (en) * 1996-03-29 1997-10-01 Kyowa Hakko Kogyo Co., Ltd. Hair-growing agent comprising a specific inhibitor of protein kinase C
WO2000048571A1 (en) * 1999-02-16 2000-08-24 Novartis Ag Spontaneously dispersible n-benzoyl staurosporine compositions
WO2002076432A2 (en) * 2001-03-26 2002-10-03 Novartis Ag Pharmaceutical composition comprising a poorly water-soluble active ingredient, a surfactant and a water-soluble polymer

Also Published As

Publication number Publication date
WO2011000811A4 (en) 2011-07-21
WO2011000811A2 (en) 2011-01-06

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