WO2010148112A1 - Expandable support device and method of use - Google Patents

Expandable support device and method of use Download PDF

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Publication number
WO2010148112A1
WO2010148112A1 PCT/US2010/038857 US2010038857W WO2010148112A1 WO 2010148112 A1 WO2010148112 A1 WO 2010148112A1 US 2010038857 W US2010038857 W US 2010038857W WO 2010148112 A1 WO2010148112 A1 WO 2010148112A1
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PCT/US2010/038857
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French (fr)
Inventor
E. Skott Greenhalgh
John-Paul Romano
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Stout Medical Group, L.P.
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Priority to US18753809P priority Critical
Priority to US61/187,538 priority
Application filed by Stout Medical Group, L.P. filed Critical Stout Medical Group, L.P.
Publication of WO2010148112A1 publication Critical patent/WO2010148112A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/4455Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages
    • A61F2/4465Joints for the spine, e.g. vertebrae, spinal discs for the fusion of spinal bodies, e.g. intervertebral fusion of adjacent spinal bodies, e.g. fusion cages having a circular or kidney shaped cross-section substantially perpendicular to the axis of the spine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/68Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/70Spinal positioners or stabilisers ; Bone stabilisers comprising fluid filler in an implant
    • A61B17/7097Stabilisers comprising fluid filler in an implant, e.g. balloon; devices for inserting or filling such implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/56Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
    • A61B17/58Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws, setting implements or the like
    • A61B17/88Osteosynthesis instruments; Methods or means for implanting or extracting internal or external fixation devices
    • A61B17/885Tools for expanding or compacting bones or discs or cavities therein
    • A61B17/8852Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc
    • A61B17/8858Tools for expanding or compacting bones or discs or cavities therein capable of being assembled or enlarged, or changing shape, inside the bone or disc laterally or radially expansible
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/16Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans
    • A61B17/1662Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body
    • A61B17/1671Bone cutting, breaking or removal means other than saws, e.g. Osteoclasts; Drills or chisels for bones; Trepans for particular parts of the body for the spine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00004(bio)absorbable, (bio)resorbable, resorptive
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2/442Intervertebral or spinal discs, e.g. resilient
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30108Shapes
    • A61F2002/3011Cross-sections or two-dimensional shapes
    • A61F2002/30112Rounded shapes, e.g. with rounded corners
    • A61F2002/30133Rounded shapes, e.g. with rounded corners kidney-shaped or bean-shaped
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2002/30001Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30316The prosthesis having different structural features at different locations within the same prosthesis; Connections between prosthetic parts; Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30535Special structural features of bone or joint prostheses not otherwise provided for
    • A61F2002/30579Special structural features of bone or joint prostheses not otherwise provided for with mechanically expandable devices, e.g. fixation devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/30767Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth
    • A61F2/30771Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves
    • A61F2002/30878Special external and/or bone-contacting surfaces, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes, grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30891Plurality of protrusions
    • A61F2002/30892Plurality of protrusions parallel
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/4475Joints for the spine, e.g. vertebrae, spinal discs hollow
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/30Joints
    • A61F2/44Joints for the spine, e.g. vertebrae, spinal discs
    • A61F2002/448Joints for the spine, e.g. vertebrae, spinal discs comprising multiple adjacent spinal implants within the same intervertebral space or within the same vertebra, e.g. comprising two adjacent spinal implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0015Kidney-shaped, e.g. bean-shaped

Abstract

An expandable support device for tissue repair is disclosed. The device can be used to repair hard or soft tissue, such as bone or vertebral discs. A method of repairing tissue is also disclosed. The device and method can be used to treat compression fractures. The compression fractures can be in the spine. The device can be deployed by compressing the device longitudinally resulting in radial expansion.

Description

1 TITLE OF THE INVENTION

2 EXPANDABLE SUPPORT DEVICE AND METHOD OF USE

3

4 5

6

7 CROSS-REFERENCE TO RELATED APPLICATIONS

8 J0001 j This application claims priority to U.S. Provisional Application No. 61/187,538,

9 filed 16 June 2009, which k incorporated by reference herein in its entirety. « 1 BACKGROUND OF THE INVENTION 2 1. Field of (he Invention 3 (0002 j This invention relates to devices for providing support for biological tissue, for4 example to fuse vertebral bodies, repair herniated discs, and/or repair spinal compression 5 fractures, and methods of using the .same. 6 7 2. Description of Related An S {0003| Some conditions of the spine result from degradation or injury to the bone9 structures of the spine, typically the vertebral body. These can be the result of bone0 degeneration such as through osteoporosis or trauma, such as compression fractures. 1 breakdown or injury to the boney structures in the spine can result in pain and spinal2 deformity with comorbidities. 3 |0(MMj Vertebroplasty is an image-guided, minimally invasive, nonsurgical therapy used4 to strengthen a broken vertebra that has been weakened by disease, such as osteoporosis5 or cancer. Vertebroplasty is often used to treat compression fractures, such as those6 caused by osteoporosis, cancer, or stress. 7 |00051 VertebropJasty is often performed on patients too elderly or frail to tolerate open8 spinal surgery, or with bones too weak for surgical spinal repair. Patients with vertebral9 damage due to a malignant tumor may sometimes benefit from vertebroplasiy. The0 procedure can also be used in younger patients whose osteoporosis is caused by long-term 1 steroid treatment or a metabolic disorder. 2 |0006| Vertebroplasty can increase the patient's functional abilities, allow a return to the3 previous level of activity, and prevent further vertebral collapse. Verlehroplasty attempts4 to also alieviaie the pain caused by a compression fracture.

SUBSTITUTE SHEET (RULE 26) 1 (0ΘO7| Vaginoplasty is often aecmnphsiied uiiediug au orthopedic cement mixture

2 fhtough a needle into the fractured bone 1 he cement mixture can leak from the bone

3 potentially entering a dangerous location such as the spinal tanal The cement nmtuic,

4 which is naturaIK useous, is difficult to inject thiough small diameiei needles, and thus

5 many praetiuoπeis choose to "ilπn out" the cement mixture to nnpto\e cenwm injection,

6 u lndi ultmiateh exacerbates the leakage problems ϊ he flow of the cement liquid aUo

7 naturally follows the path υfleast teststaace once it enters the bone αatuiadv along the

8 αacks fotmed duπng the compiessson hactuie This fuπhei exacerbates the leakage,

9 JΘ008] I he mixture also fills or substantially fills the cavity of the compression fracture H) and is. hmited to certain chemical composition {hereto limiting the amount of otherwise

11 beneficial compounds that can be added to the ft actiue /one to

Figure imgf000003_0001
healing In an

12 jϊteπiiUn e procedure know n as kyphoplasi v , a balloon ts fust inserted in the compression

13 fracture and the \ ettebra and is expanded to create a sosd befoie the cement is injected

14 into the new Iy formed space

15 jθ009| A veτtebropl3si"v device and method thai ehmmatcs* or tedoces the usKs* and

1 o complexity of the exisisng att is dcsπed A

Figure imgf000003_0002
dεx ice and method that urn

17 i educe or eliminate the need to inject a liquid direct!) into the completion ftactore /one

IH is also desued iv føOJOj ()ιh« ailments of the spine iestiit m degeneiauon of she spinal disc iu the

20 mterv ei tebral space

Figure imgf000003_0003
\ et tebral bodies I hese include
Figure imgf000003_0004
e disc

21 disease and traumatic mjuπes In either case disc degeneration can cause pam and other 2 complications Consm atn e treatment can include

Figure imgf000003_0005
treatment requiring 1 pauents to adjust their Wests lcs> and submit to pam reliefers and a ie\ e! of underlying

24 pam Qperatπe Ucatment options include din* r

Figure imgf000003_0006
emo\al This can pam in the short

2^ leim. but also often increases the πsk of long-tain pioblems and can result in inotoi and

26 sensoty deficiencies iesultuig tiom ihc suigetv Disc

Figure imgf000003_0007
mά moie general!) disc

27 degeneration disease aie bkclv io lead to a need for surgical liealracnt m subsequent 8 } eon, ϊhc fusion or fixation v. ill mimmi/e or substantial!} eliminate rdatn e motion () between the fixed oi f used \ euebuie In Skiugical lreaiments adjacent \eitebra can be

30 fixated or fused to each othei using dexiccs ot booe grafts These ma\ include, fot

31 example, screw and rod s> stems, mteibody spaceis (e g , Pfc bk spacers oi allograft bone

32 giafts) threaded fusion cages and the like

33 jOOll) Some fixation oi fusiou devices are attached to the

Figure imgf000003_0008
ftonϊ the postenor M side Flic dc\ ice \s ill protmde and s esult m additional length ( t e needed to ov erlap the 1
Figure imgf000004_0001
Fusion cages

2 and allografts are contained vuthin the intervertebral space, but must he inserted into (he 1 mtenertcbrai spate m She same dimensions as desiied to occtnrv the mtenertebtal space

4 This tequnes that an opening sufficient to allow the cage oi graft must be eieated thiough

5 suuounding ussue to peiimt the cage or gtr ft to be wseued into the tntetveslebial space

6 [OOI2|

Figure imgf000004_0002
w ithoitt the need ^ for additional IiaaKsaie ΪS desπed Also desued is a fixation ot fusion device that can be

8 deployed in a cuofiguiation where overlapping the fixated or fused

Figure imgf000004_0003
is not

9 required

H) JΘ0I3] AUo desired is an intervertebral dexite the ma\ he inserted m to the mlmertebral

11 space at a Hist smallei dunensjon and deployed to a second, laxgei dmiensiυπ tu occup>

12 the jiiten αtebrai space The abihtj to insert an inteπ eitebral spaces at a dimension 1 ^ smallei than the depfoved dimension w ould permit less disπiptrøn of soft and bone>

14 tissue in ordei to access the mtervenebiai space

15 jθO14| Aπ effectne ιlictap"v ioi follow mj. up a discectυim is desned A

Figure imgf000004_0004
tusion 1 C' technique thai can be used subsequent to a Jhcectonπ is dcsuεd

17

1 H SUMMARY Or THE INVENTION iv f00J5j An expandable support

Figure imgf000004_0005
that can be used m iepair (tactures and stabilize

20 hard tissue such as \ ia mtra\ ertebral or mien ertebraϊ deplox mem, is disclosed T he

21 expandable suppoit dc\ ice can ha\ c a longittkimal axit. and a iadial a\is f he expandable 2 support

Figure imgf000004_0006
ice can be conikiued to expand m a iadial duection, for example constrained 3 to expansion in a single dimension I he deΛ ice can expand perpendicalit to the

24 longitudinal axis of the

Figure imgf000004_0007
ice can
Figure imgf000004_0008
top and or middle and or bottom 2"> components ϊ he top aπd-or middle and oi bottom components can
Figure imgf000004_0009
oi

26 wedges that produce an opposing (oice to expand the

Figure imgf000004_0010
ice when the top and υr middle

2n and ot bottom components ate kaπsLucd rclatπ e to each othei m the Iongitudmal 8 diicction For example, the deuce can expand tadialh (e g soleh in height or width} ()

Figure imgf000004_0011
lonaitiidmalK Height expansion can octoi alone a vupeuor-mfeπoi

30 axis when the device is positioned m the spine

31 {00161 1 h*

Figure imgf000004_0012
tee can be conftguied to expand in a smgle du εctioπ I he
Figure imgf000004_0013
can be

32 coniieuied to expand m

Figure imgf000004_0014
directions

^ {0017) The tJeute can have a locking pin The locking pm can be mterfeience fit with

M nroving and or staiionaiv components of the rematrtdet of the dev ice For example the 1 ktekniL' pin can into feieuce fit w ύh the fust sϋuL and'Oi w itti a longitudinal port of the

2 dc\ ^c

3 [8018] Methods for dcpkn ing an expandable support

Figure imgf000005_0001
sec in the spine are disclosed

4 The expandable suppott

Figure imgf000005_0002
longitudinal

5 concession The longitudinal αmipjesstou can result tn iadial expansion of the

6 expandable Λtppott

Figure imgf000005_0003
ice 1 he expandable support d<Λ see can be deployed in an

7 sue The expandable sitppon

Figure imgf000005_0004
see can be deployed in an
Figure imgf000005_0005
euebtal

8 site

9 |0019| Fools for deplo\ ing the expandable support device can be configured to apply a

10 compressn c force on She expandable support deuce along the expandable support

11 I he tools can be configuied io secure!) engage the

12 e

Figure imgf000005_0006
xpandable suppca t ice The tools can be confirmed to
Figure imgf000005_0007
abϊv attach to opposing

13 pomls at oi near opposing longitudinal ends of the expandable support

Figure imgf000005_0008
ice Actuation

14 of the tool to apph a

Figure imgf000005_0009
e foice may include squeezing two handle., together oi

15 rotating a knob or handle

1 C' JΘΘ20] The expandable

Figure imgf000005_0010
can be filled % sϊh a material, such as a biocompatible

17 material such as a bone mcuphogenie ptolein, bone cement oi anv other mateπal listed

1 H herein and combinations theieof For example, w hen used to tieat compr«si>toa fractiu es, iv a nmieπal such bone cement, us^ue « bone gtowUi factois. bone morphogeny proteins,

20 stem cells earners Sbi anx of the foregoing, or mixtures thereof can be insetted v\ tthm the

21 expandable de\ ice to pτo\ idc support fixatJon and or improx cd bone stt ueiure Grow Sh 2 factors or stem ceils can be obtained autologous!) , such as from the patient's

Figure imgf000005_0011
3 or bone marrow aspirate [he expandable
Figure imgf000005_0012
ice can be filled with aotogi aft, ailogtaii, 4 bone extenders tc g , calcium phosphate ortπcalciura phosphate or mtxSυtes thereof or "> othei iimilai mateiuis), bone giow ih factor^., bone moiphogenic pioiems, stem cells, 26 cauieis tot anv of the foicgomg. and πuxtmes theteof (or example, when the de\ ice is 2n used as an niierxcttebral spacei fot fusion The giowth factois and stem cells used can be 8 those commercially
Figure imgf000005_0013
aifcώie and oi can be exti acted Aom the patient's
Figure imgf000005_0014
blood oi () bone raarraw aspirate 0 J0021] In addition the rauo of the expansion tot the expandable
Figure imgf000005_0015
{the iatio of the 1 unexpaiided height or diameter, depending on configuration, to the expanded height oi 2 diameter) ma> be from I 2 to 1 5 or greater i-or iniraxertebml and imeneπebial 3 αppiicauons the dev ice
Figure imgf000005_0016
expansion tatios of ftom about I 3 to about 1 4 Tm
Figure imgf000005_0017
can hax e an initial height or diameter 1 fiυin about 4 ram (0 16 m ) to about 8 mm (03 i in ) and an expanded height w diametw

2 ft otii about 7 mm (0 2H in ) to about 18 mm (0 7I m )

4 BRlCr DESCRIPTION Or TI IE DRAWINGS

5 [0022 j Figui «J 1 a i Slusti ales an exploded v tew of a \ adαuon of the dex ice

6 [ΘΘ23J Hguie Ib is a \ aπation of crnss-^eetion ia

7 [9024f Figute 2a dlusuates a \

Figure imgf000006_0001
ai iatiou of the m a height-contracted configuiaUon

8 I00251 Figut e 2b is a sanation oi cross-section B-B ot Fsgωe 2a.

9 JΘ026] Figure 3a illustrates a \anauori of the device in a height-expanded configuration

10 |0027] Figure 3b is a variation of cross-section C-C of Figure *a

11 (Θ028J Figure 4a is a top \

Figure imgf000006_0002
tew of a of the
Figure imgf000006_0003
m a height-contracted

12 configuration

13 [0029| tiguie 4b is a top new of a \ aπation of the deuce in a heigk -expanded

14 |0030j f-iguies 5a and

Figure imgf000006_0004
the

15 shown in cioss-seciion.. B-B and C-C.

Figure imgf000006_0005
, of Figmes 2a and 3a

1 C' JΘΘ31] Figute 5b iUusttatcs a vauation of a method for using the dex ice

Figure imgf000006_0006
mg a

17 \ aπation of a cro^ -section C-C of Figure 3a

IH (0032 j Figures 5c and ?d Ulusnate vaπaisoαs of a method foi using the

Figure imgf000006_0007
see
Figure imgf000006_0008
a iv \ aπation of a cross-section C-C of Figure 3a with a depkmneiu tool and-or loclmg iod

20 {0033J F tgurcs 6a and 6b are side pei spccuve and top perspectn e \ tews, respcctn eiy or

21 a variation of the device in a height-contracted configuration 2 [ΘO34| hgures fia1 and 6b' are side perspective and top perspectn e \ lews, respectn eh , or 3 a 1V ariation of She

Figure imgf000006_0009
in a height-expanded configuration 4 [0035] Figures 7a through 7c are a close up ^ ie*\ of a method of using She deplo> men! "> iod or locking pm w ith the second side poκ shown in a cross-sectional
Figure imgf000006_0010

26 [0036] Figures 8 and 9 illuhUαw a sanation of α method for using a delivery system for

2n the expandable suppoti elcrncni 8 [0037| Figures i 0 through i 2 illusirate a x ariation of a method foi accessing a damage () .site in the s ei tebra. 0 JΘΘ38] Figute S 3 illusthrtes two methods fot

Figure imgf000006_0011
eπng expandable suppoit devices to the 1 \ ertebral column 2 |003*>] Figures 14 through V) illustiate methods for dep!o> mg the expandable 3 support
Figure imgf000006_0012
ice into the damage sue in the \ettebia 1 |Θ040| Psguies 2St and 21 iliushate a \ aiiatioti of a method foi depicting one in mote

2 expandable support de\ ices into one or moi e damage sites in the \ erlebia

3 J004I] Figure 22 illustrates a \aπaUαn of a method foϊ deploying the expandable support

4

Figure imgf000007_0001
the \ ettebta

5 |0D42j Figuie 23 illustrates vaπaUons of methods for depSov ing the expandable suppon

6

Figure imgf000007_0002
the \ eriebra

7 [0043 j F*guiei> 24 and 25 tliustiate a \ aπauoα of a method foi deploying the expandable

8 support

Figure imgf000007_0003
l> |0044| Figures 26 through 2V illustrate a variation of a method for deploying the

I 0 expandable support

Figure imgf000007_0004
ice between adjacent s cπebrae

I 1 f©045J Figures 30 thiough 13 1 liusuate a \ aiiatioii of a method fur dep!o> ms* the

12 expandable suppoi i

Figure imgf000007_0005
ice betw eeti adjacent \ ertcbtac

13 [0046| tiguies 34 and 35 illustiate aiaiwUion of a method foi deploying a locking pm

14 into the expandable suppoit de\ ice in the damage site in the vertebra

15 jθO47| Fsguies Mxi and 1^ 6b iUusliaic \ anal ions of methods foi inseituig one ot mote 1 C' de\ lies mto one or mote iaiget sues

17

1 H DETAILED DESCRIPTION* iv f0048j Figutes 1 a and Ib illustrate asϊ exploded

Figure imgf000007_0006
2

20 that can be implanted m a bone such as s compiession Aacture m a \ ertebra, m the

21 mteneitebral ^pace between two vertebrae or in so R tissue, ^uch as a herniated 2 mteneπebral disc fhe expandable support

Figure imgf000007_0007
ice 2 can be biocompatible The 3 expandable support de\ ice 2 can be used, lot example, for methods of repairing \ crtcbral

24 bone ftaetiires oi supporting adiacent \ ertebrai hodiκ> foi foMon The expandable support 2"S 2 can

Figure imgf000007_0008
a fit st longitudinal end a.id a second longitudinal end alυng a

26 longs t iidinal atis 4

2n [0049| The expandable support dc\ ice 2 can

Figure imgf000007_0009
base oi botiom (w
Figure imgf000007_0010
and bottom 8 iuc used interthangeabh V a middle 6b, and a top component f>e The base or bottom fta () and top 6c can be ot
Figure imgf000007_0011
plates, panels sififc (e g . leμsi porfc, ceils, and combmations

30 thereof The base 6a i\nά top 6c can he configured to be slidabh attachable to the middle

31 6b fcnhei the top 6c, the base f>a, or neilhβ , tshown in the iigυies as Jie base 6a) can be

32 shdabl) attached to the middle 6b in a plane paiallei with the longitudinal aκis 4 hitliei

33 the top 6c the base 6a, oi neufiei, t show n m the as the top 6c) can be slidabK

M attached to the middle ftb m a plane sυbstaaually perpendicular to the longitudinal 4 1 (0ΘS0| The tup 6c can

Figure imgf000008_0001
e one oi mote top slabilits hats St Fot example, the tup

2 stability bars Hc can extend from the iaiciai sides of the top 6c I he fop subshtΛ bars Hc

3 can extend from the top 6c in the direction of the base 6a The base da can

Figure imgf000008_0002
c one oi

4 more base stabihtv guxπes IUa Each top stability bai Sc can he confirmed, to be

^ slidabK attachable to a cunesponditig base stahshrv gioose I Oa Foi example, the top 6c

6 can have two seK of one, two or more symmetntalh opposite, lateiail) located top

Figure imgf000008_0003
ol tw o s>\ mnwscaJ!} apposite,

8 lateialiv located base siabihrs guxne.s H)a, as shown

9 |00511 Fhe base Oa can have one or more base stabthh bars Ha For example, the base

10 siabtiii) bars Ha can extend from the lateral sides of the base 6a lhe base slabiltf) bars

11 8a can extend fiom the base in the chrecuon of the top 6c I he top 6c can ha\ e one oi

12 more top stabihl} gtooses IUc The base stabihtΛ bar& Na can each be configtπed to be

1

Figure imgf000008_0004
1 Oc hot example the base 6a

14 can ha\e two sets of one, two, ihree (&> ^hown) oi raoie s>rameincalfy opposite fatera!l>

15 located base stabiliU bats 8a The top 6c can

Figure imgf000008_0005
e U\o or more sets* of Iw o. three f as Ut sh(mn) or more wrnmctπcaH\ opposne ia eraih located top stabihtv grooves 10c, as 1 "* ihow n

1 K {0052 J The shdable attachment υf the top H and base 6a can pei rou the base f>a to raov e iy iadialh {w tth jespect to the iongHudtual a Mb 4) telatt\e to Lhe top 6c and \ ice \eisa For

20 example, the top 6c can extend superior!) away from the base 6a w hen the

Figure imgf000008_0006
JCC 2 ts

21 inseited in an mtcnertehrai target site 2 |0053 j i he top Oc can ha\ e a htgh-fπctton te\tute and or a low -fnction surface extending 1 a\\a\ Aom the base 6a on the surface faemg avun ft om the base 6a tor example the top 24 he can ha\ e one or numerous row s of top teeth 12c The bottom 6a can ha\ c a high-

Figure imgf000008_0007
fiυm the top be Foi example, the

26 boitorn can

Figure imgf000008_0008
one oi numcioos ums of bottom teeth The top teeth !2c an&oi the

27 bottom teeth can he rigid The teeth 12 can be at tanged to hax c ndges parallel w ith the 8 iongjtudma] axis 4,

Figure imgf000008_0009
w ith the iongitudtnal axis 4, at a non-zeio and noπ-nght () angle lυ the longitudinal a\Ls 4. oi combmations thef eυf The top aiid-or bottom sui faces.

30 can has ε hone ingrowth mat! ices to encoutdge

Figure imgf000008_0010
Ih from the surrounding bones to

31 fix the bones to the top 6c and or base ^a

32 {0054 J I he top 6c can b^ e one or more side ports and or top poits 14c 1 he base 6a can V* one oi moie base potts 14a amJ'Oi side pons The ports 14 can be cneuUi squate 1 tnauμuiai υ\ al elongated m ύic longituduud dueαsαn. elrugated in the iadial direction.

2 or combinations ihereof

3 J805S] F he top 6c and or base 6a can ha\ c atiaiimauc edges, such as chamfered

Figure imgf000009_0001

4 The chainlets can euend along the peπmetei of the base 6a and or top 6c

5 |0D56j The expandable support device 2 can

Figure imgf000009_0002
one, two, Uu ee or moie sets of

6 interacting

Figure imgf000009_0003

"7 along the length of the dev ice, ui the sets of samps can be dtsuibuted

Figure imgf000009_0004
along the

8 length of ihe base

9 |0057| Fhe lop 6c and or base 6a can ha\ c a series of unidirectional and or bidrectional

0 O ramps For example, the top f>c can hav e a lop first ramp i 6c', a top second ramp 16c"

11 and a fop thud ramp 16c"' The umdnecuonal iamps 10a and oi 1 f>c can be configured to

12 have a rαmp stop IH at one longitudinal end of the ramp S 6a amioi 16c For example, the

13 ramp stop 1 H can be the face of the ramp that w closer to a petpendicuisr angle to the

14 longitudinal a\ts 4 than the othei iace of the ramp

15 jθO58| The middle Ob can

Figure imgf000009_0005
a seues> of iiiκhτectional and or hidreciionai ramps, such

16 as middle firvt ramp 16b' nuddie second ramp i 6b", and middle thud ramp i 6b"' The

17 umdiiccnonal ramps 16b can be configuicc" to

Figure imgf000009_0006
a ramp stop IH at one longitudinal IH end ol ilie ianip 16b iv |005£j The lamps 16 can ha\e lamp leagues and correspond groo\es 20 on adjacent

20 nimps Ramp tongue and groo% Cs 20 on corresponding ramps 16 can be configured to

21 ilidably attach to the opposing tongues and g

Figure imgf000009_0007
roo\ es 20 For Ac top ramps 16c 2 can top tongues and grooves The middle ramps 10b can
Figure imgf000009_0008
middle tongues and 3 grow es 20b that can slidabl> engage the top tongues and gioov es 4 [8MO] Fhe ramps 16 can haλe ramp angles 22 with ictpcct to the longitudinal axis 4 "S I he ramp angle 22 can be fiom about 1^° to about 7i;>t\ mote narrow K from about 20° to

26 about (AY for exaπiple about ^0

2n |00611 One or more of the lamps 16 can have ά tamp stop 18 The iamp slops Ih can be 8 configured to abut and mteifcrence fit against a cones ponding ramp stop i H on the () adjacent element O e . ihe top 6c can be adjacent to the middle Ob i 0 JΘΘ62] The base Oa {.as* skmπ) and OJ top 6c can

Figure imgf000009_0009
<ι fftst side plate 24i, for example 1 at the distal longitudinal end of the base 6a 2 |ΘO63) I he base 6c can
Figure imgf000009_0010
a base rail 26a Hie middle 6b can ha\ e a middle rail 2(>b 3 The middle rail 26b can be vhdabh fed owto or under the base rat! 26a The base tatl 2(>a 1 and the middle mi! 26b can coiisitaui motion bem ecn the middle 6b mid me ba.se

2 6a to the linear dimension of the longitudinal a\is 4

3 |ΘO64] The fust side port can

Figure imgf000010_0001
a fiist side outer pou 28a on the first
Figure imgf000010_0002
plate 24a

4 The fust side port can bm e a Hi st side cents al pon 28c in the top 6c The fiisi side cential

5 pon 2Sc can be open on the bottom, foi example to ailov the Ht st side cenUal pυit 2Sc to

6 moλ e av\ ay from the first side outer post 2Sa w ithout constraining any rod oi other

7 elongated element positioned through the i'tst side poit The middle 6b can ha\e a fust

8 side inner pou 2ISb tfuough the middle fust t amp S 6b', The first stde outei. central, aud l> inner ports 2Sa, 28c and 28b oi a combination thereof can be internally threaded The

0 O first side outer port 2Ha can form a recess in the first side plate 2Ha. for example to

11 iecen e the head of a i od

12 [00651 The base 6a can

Figure imgf000010_0003
one oi inoie nunp seats JO, for example, the ramps seats 30

13 can be positioned to coπespond with and receB e one oi moie of the top lamps 16c, for

14 example w hen the de^ see 2 is in a height-contracted configuration

15 jθO66| The top lamps 16 can be positioned iatωaik s\mmeti it-ally on the top 6c The top

16 ramps 16c can be

Figure imgf000010_0004
distributed along the length of the top 6c The ramp scats MJ can

17 be positioned iateralh

Figure imgf000010_0005
base 6a 1 he ramp scats 30 can be
Figure imgf000010_0006
1 H distributed along the length of the ba^e (>a iv f0067j Figuies 2a and 2b illusttate that tbe deMce can have a height-conn acted

20 configuration fop ramps 16c can receive the middle ramps ϊ6b The ramp stops IH of

21 the top ramps i 6c can mterfeience fit agamM the ramp stops 18 of the middle ramps 16b 2

Figure imgf000010_0007
2 can e a height-expanded 3 confirmation 1 he middle 6b can be shdabh translated tow ard (lie first or pioximal 4 longitudinal end of the de\ ice 2 "S (006θ| The top and/or base stability bais 8a and or 8c can be configured tυ not dnect1>

26 attach to the top 6c and oi base da when the stabihn bar & is* translated toward the

27 opposite stability grπo\c tOa and or 10c, and or the stability bars M can be conllgiiicd to 8 bia* mwaid against and fπctionally hold the top 6c and base 6a togcthci uhen the top 6c () W translated into contact

Figure imgf000010_0008
stfa the base 6a 0 J0070] The Lop Oc and the base 6a can be pressed into or oihctvusc translated tow aid each 1 other t oi example, after implantation of the expandable support
Figure imgf000010_0009
ice 2, the 2 surrounding tissue m the in ^
Figure imgf000010_0010
em ironment can naturalh compress the expandable 3 support des ice 2 The tamps 10 can hav e i atchets on then sui faces m the tongue and

34 groove 20 snά or elsew here to enl coiiiraclion once the dex ice 2 is or 1 rαdiaih expanded The

Figure imgf000011_0001
2 can be filled a aiatcuai and oi tlie deployment tod

2 can be lived to the first s?de otitei port 28a ind the second port

3 {8971] In place of or jn addition to, the ba-*e teeth and OΪ the top teeth I 2c, the

Figure imgf000011_0002
e

4 si« taces can

Figure imgf000011_0003
high f i ietton sud aces foi example a textured (e g knurled) sin lace

5 and oi be coated w ith a high friction material (e {> PTFC such as Teflon)

6 [00721 Hguies 4a and 4b illustrate thai the top pen i4a, middle port 14b and base pou ^ i 4c substantial!) align parallel oi uansv erse w jth the longitudinal axϋ> 4 The top

8 middle and base ports 14a, 14b and 14c ftrro a concurrent \ eiticai pott 32 thiough the

9 dc\ tee 2 I he concun em vertical port 32 can be filled w tth an\ material disclosed herein

10 oi leit eniptv F he concurrent \ crtJcal poit 52 can be partiallv obbtnicted b\ the middle

11 6b including the middle first iarnp 16b' w hen the

Figure imgf000011_0004
ice 2 is m a heiglu-cuiita acted

12 ujnhguuttαn, a> shown in Figure 4a The αincuttent vertical port ^2 tan be less π obstructed oi substantialh unobstructed when the de\ ice 2 is in a height-expanded

14 configuration as shown so Hume 4b

15 (ΘO73| Fiauie 4a illustidtes that the middle 6b can pioirude outside of tiiε fooipruu of the Ut top 6c and bottom Oa when ihc

Figure imgf000011_0005
sec 2 is . tewed from above or below in a height-

V conn acted configuiatioii

Figure imgf000011_0006
VJCV\ the nuddlc

1 K 6b can be suln.taRUalis tlush w αh the top (>c and bottom 6a w hen \ lev, eά fi cm abov e w

19 below ice 2 is in a haight-contt acted conllgutanon

20 |t)(.)74| Figures >a and >b illustrate the height expansion, as shown by arrow >4 of the top

21 όc tuun from the base ^a The height expanMon can octui when the device 2 is, 2 ioαgιtudmall\ compte^sed and os when the miάάte 6b is slid, as shown b\ auow Io with

Figure imgf000011_0007
the fust side

24 [8075] Figure

Figure imgf000011_0008
b} s

2"S ^8 against the top ramps 16c when the deuce 2 is expanded V resistive force as shown

26 bv aiiov* 40 can be deliveied against the bise 6a for example to allow the siding iouε

27 as show rt b> arrow s *6, to be dehvcied to the middle ^b The remvm e force can be 8 delneied to the first side port, foi example diiectl} to the outci fiibt side port 2Ha () (0O76| Fsguie ^c dlusUatεs that the middle 6b can ba\e a second ^ide poit 42 Λ

30 deployment tool an J or locking tod 44 can be inserted thtough the Hi st port 28 and the

31 second side poa 42 The deplo>meni tod 44 can have an attached oi iπtegial depiojmeni

32 iod cap 46 oi nut thai can be outside the first port 2S and inteifeience in with the wall oi ^ the In st side plate 24a suirounding the first port 1 J0Θ?7| The tod 44 tan be pulled {as shown by anon 36) while a iesisine fυice (shown

2 by at t cm 40} is applied to the de\ ice 2 to oppose the pulling foice < to expand the dev ice 2

3 lathes than sole!)' pulling the

Figure imgf000012_0001
sec 2 low aid the usci)

4 (0078) The deplo> jnent rod 44 ui lucking pm can hme a pin shaft wnh a

Figure imgf000012_0002
slot for

5 example, coufiguied to

Figure imgf000012_0003
pm

6 thiead 48, as

Figure imgf000012_0004
tn Figures "7Si-Ic, configined to ieleasably ot frvedh attach to one OJ ^ both of the ramp poib 28 and oi 42 The pin thread 4K can extend along all CM pait oi the

8 length of ihe pm shaft

9 |(K)79| Fhe locking pm 44 can be inset led, as shov\n bv arrow th tough tlie threaded ramp

10 ports 42 and or 28 The dcpkn ment rod and locking pm can be the same or diffeiem

11 elements

12 [ΘΘ80] The second bide plate 24b and oi the lop 6c and<or the bottom ds tan

Figure imgf000012_0005
α i amp 1 ^ abutment section, such as tlie iamp stops 18 ϊ he tamp abutment section can be

14 configured to mlerfeience fit w ith and oi

Figure imgf000012_0006
attach to the abutment end of the

15 deployment tool wheie the abuuπent end can be used to

Figure imgf000012_0007
tlie pushing ot pulling 1 C' foice Jgauist the proximal end of the dc\ tec 2 {<e g adjacent to the second side port)

17 jøOSl) A rod detent 52 can be fitted onto ot though the deployment tool ot locking rod

1 H 44 The uset can deploy a force against th€ detent ^2 The detent 52 can be a dtp, nut iv biad, loekable skde, ot cotnbuianons thereof The detent 52 can fh to the deployment

20 κ>d Ot locking pm 44 and mterfetenec ill against the middle 6b For example, the middle

21 6b can then be fixed between the rod detent ^2 and the first Mde plate 24a 2 [00821 hgute 5ά illustiates that the depioj ment rod or lockmy pm 44 can be integral oi 3 attached to the middle 6b, for example at the second stdc plate 24b 1 he middle port can 4 be unobstructed by the i od or pm 44 "> {0083} 1 he deploj ment rod 44 can be lemøv abh attached from the iemamdei of the

26

Figure imgf000012_0008
rod 44 can be used

2n to position and expand ihc

Figure imgf000012_0009
tee 2 8 [Θ084 j f-igui os 6a and 6b illustrate that the de\ see 2 can ha^ c a an \ ed configuration Foi () example, the lonμjtodnial axis» o( the
Figure imgf000012_0010
can hav e a n\&m o( cur\ at me 54 The

30 Jongitυdmal axis 4 can pasi, through the tians\ eiie middle ol all potnb along the length υf 1 the

Figure imgf000012_0011
(0 5 m \ to about "> 6 2 cm (3 in }. more naπøvtlx from about 5 cm (2 in ) to about 7 cm (2 75 in } foi example ^ about ς cm (2 in ) The radius ofcutvatute ^4 ca« be Lonstanl or variable υvef the length M of the
Figure imgf000012_0012
^4 can be scaled larger for larger implants and

i i 1 scakd smαiltM for smaSlet implants For example tecs 2 tot use in the thoiaeic

2 veitebrae can

Figure imgf000013_0001
1 cm {,() ^ in ) to about 5 i cm (2 in ) 0e\ sees 2 for use in the lumbar \ eπcbrae can ba\c a radius of curvature 54

4 I torn aboui 5 cm (2 in ) to about 6 4 cm (2 T in )

5 |0D85j The configuration of the top (u,, middle Ob, b<u»e ^a. ot combinations thereof can

6 be ciji \ ed to match the curv ature πf the de\ to? 2 The elements, of the top 6t , middle 6b

Figure imgf000013_0002
of the 2

8 The locking tod 44 (not shown m Figure oa and 6b) can be

Figure imgf000013_0003
to match the cuixatuie

9 of the dc\ tee 2

It) JΘ086] Figures 6a' and 6b' illustrate that a compressive force, as shewn

Figure imgf000013_0004
arrows %, can

11 be deln er ed along the longitudinal

Figure imgf000013_0005
force can be

12 deployed agαmsi the middle Ob on the piovima!

Figure imgf000013_0006
of the
Figure imgf000013_0007
ice 2 and against the first 1 ^ side plate 24a and or first side outei port 2Sa on die distal side of the de\ ice 2

14 [ΘO87f Phe middle 6b can slide m a eun ed path along the longitudinal axis 4 w ith respect

15 to the top 6c and oi bottom 6a The middle umps 16b can p

Figure imgf000013_0008
it^s and against the 1 o coπespondπig top tongues and' or gioo\ cs 20c The top 6c am expand Λ CJE ticaih , as

17 show n b> arrow 34, awa> from the bottom 6a

IH |0088| The

Figure imgf000013_0009
2 can be uisetted nno a jeatraem aiea along a ed path foi iv example, the cuned path of delneo can have a substammlK equal iadtus of tuix atute to

20 the raduts> of ciin aiiirc ^4 of She de\ ice 2

21 [0089| i-tgurc 7a illustrates that the second ssde port 42 tan ha\e port thread ^S on ail or a 2 portion of the mside of the port I or example, the second

Figure imgf000013_0010
3 thtead ^H on about half of the surface ofJhe inside of the port 42. foi example from

24 angles about 0 degi ces to about 1 SO degrees \\ hen measured from a ioπguuduia! a\is

2"> passing through the centei of the second Side poa 42 (as shown) oi fiom about 0 Jegiees

26 to about 0O degrees and then again fiom about I SO degrees to about 2"0 degrees

2n [0090| The dcpiox ment rod or locking psn 44 can have rod OJ pin tJhiead 48 on ά poiUon 8 of the sulfate of the tod or pin 44 corresponding to and substantially equal to or less than () the pot uoH of the siu (ace of the inside of the port 42 eo\ cied bv pυi t tluead ς>> Fot

30 example, the tod OΪ pni 44 can ha\ e iod or pm thread 48 on about half of the swtacc of

31 the outside of the rod or pin 44, for example from angles about 0 degi ees to about 180

32 degrees w hen measuied from a longitudinal axis passing through the center of the tod or ^ pm {as shown) or from about 0 degrees to about 0O degrees and then again fiυm about M ! 80 degrees to about 21) degrees 1 J0Θ9Ϊ| The non-tlaeaded put lion of the stuiate of the tod 44 can be angukth aligned

2 w lib the threaded portion of the surface of the second side poi i 42

3 {0092J Figure "D illustrates thai the rod or pin 44 can be translated into ot through the

4 second side port 42 The iod pm thiead 48 can shdabK pass actors the innei surface of ^ the second side poU 42 not having pott thiead ">S The pm thread 4h can shde past (he

6 outer surface of the second side port 42 not

Figure imgf000014_0001
sng poit thread ^H

7 [0093 j figuie 7c iliustiaie-* that when the rod or pm 44 is at a desned powuoα ihe tod oi

8 pin 44 can be i oiated to align the rod or pin thread 48 w ith the pott thread 5h The iod t>ι l> pin 44 can be iπmslatably fixed wuli tespect to the second side poit 42 for example

10 because of an tnterleiencc fit between {he pm ihiead 48 and the port thietid *uS

11 |00*>4J lhe paiiiai-thieαd shown on the second side pott 42 m

Figure imgf000014_0002
^a thiough nc can

12 be on a sepaiate nut rouiiabh attached to the second side poit 42 For example, once the H rod oi pm 44 is in a desired position, the tut can be iotated w Uh respect to the rod or pin

14 44 to Iongitudmalh

Figure imgf000014_0003
the position of the rod oi pm 44 w ttli respect to the nut and

5 S theiefote the second side port 42

10 J0095] A biocompatible adhesn e ot cpox\ cjn be applied to the pin tkead 4h threaded

17 iamp port 42, abutment end ramp abutment section, or combinations thereof

IH (0096) One, mo oi mote lucking ptn chao«eb oi poits can be inserted iongUudmalK into iv the expattdable suppon de\ fee One, t\\ a oτ raoie locking pitis can be i»ϊ»et ted into the

20 same or sepai ate ports foi example duimg or after deployment of the remainder of the

21 expandable ^uppoM dc\ ice 1 he locking pins can ρrc\ ens σv CM expansion and or 2 o\eι completion and OΪ dswsserabh of the expandable suppoit de\ice 3 JΘ097] Once the

Figure imgf000014_0004
see ?s expanded and oi before expansion the tamps can hax e locking 4 pins insetted therethrough "> fOO*>S| 1 he locking pm 44 can be c\ hnduαi I he locking pm channel mid locking pin

26 poti can

Figure imgf000014_0005
elongated ctoss-secuons such as an owii or tectanguiar oi oblong crøss-

2n sections The locking ptn an he free to mo\ e \ erticalK w itJbm a iangc of motion v\ ithiπ 8 the locking pin port () \Q®99\ The lυckma pm can be a subsUratialiv siniikt shape and sj/e as the locking ptn

30 channel The locking pm can be substantial

Figure imgf000014_0006
Socking pm port 1 lhe locking pm locking pin channel and locking pin poit can all
Figure imgf000014_0007
elongated cioss- 2 sections such as an ouii oi recfangulai or oblong αuss- sections 1 J0ϊøø| The iamps can has e first living teeth at ratchets The fust fixing teeth can be m

2 contact w ith the top and or the bottom The top and-'ot the bottom can have second fixmg 1 teeth

4 fOlOI) The fust fixing leεth can mechamcrlly inteiact with the second fixing teeth to

5 aliow reiatrve nansialiou m a first direction The first [rung teeth and the second fixing

6 teeth can mtesaα to obsiiuct (e g , b\ interference fitting the hxbi fixing teeth against the "7 second fixing teeth) ielam e translation m a second direction For example, the faing

8 teeth can obstutct the top tamps horn mυung one

Figure imgf000015_0001
foi example not allowing the

9 dc\ tee to contract and obstruct the top from men nig closer to the bottom Also for H) example the fixmg teeth can allow relative translation of the side ramps toward each

11 othei, foi example, to allow the top to

Figure imgf000015_0002
away from the bottom

12 [Θ102J The device 2 cars have a Hist ordisial end The first end tan be confirmed to

13 dissect tissue, lor example being sharpened to a point or chisel tip, or can be atraumatic

14 for example being blunted

15 jθi03| The second or piovimal end can

Figure imgf000015_0003
a too! connector such as in eucuiaih

16 and<'or internal H threaded c\ lindci extending longftudmallv from the second oi pioximaϊ

17 side and aw a\ fiom the fa i»t or distal side Hie tool connector can be con figured to 1 H attach to a deplo> ineru tool iv (01041 The tamps can

Figure imgf000015_0004
fitst fixing teeth that can unidtteeiionalK iinetference Ot

20 second fixing teeth on adjacent ramps or ramp seats The unidirectional interference iit of

21 the first fixmg teeth and the second fixing teeth can substantial!) impede or prex cnt the 2 opposite ramps from moving longjtadmalh aw ay from each other for eκample, therefore 3 impede or

Figure imgf000015_0005
the top 6c tow <jrd the bottom 6a and \ tec \ ers<j δ ficr

24 the ice 2 is, insetted and deplo\ ed in a taiget site

2"> (0105J 1 he unidirectional mtei feience fit of the fii st fixing teeth and the second fixing

26 teeth can allow the opposite uunps to mo\c longitiidinailv toward each othei lbi

2n example, thcieforc allow ing the top to expand

Figure imgf000015_0006
and \ ice Λ
Figure imgf000015_0007
8 [Θ1O6| \n externa! dcploymeni tool can be attached to the in si side plate and the second () pott of die side of the deuce amlapplv a compiesbne lbtce actoss the device The base

30 and top can expand aw ay from each other, as show n bv arrows

31 (0107] When the expandable support

Figure imgf000015_0008
me

32 expandable support deuce 2 can be patually oi sαbstantmllv filled \uth a liquid gel or

33 solid ie g in small parts oi gmuuies) fillet material ot combinations theieof, as

M bone morphogeny ponder or an) othei material disclosed herein or combinations thereof 1 The filler material can comae L oi be m uear contact with the simoundmg tissue neat the

2 edge of the pom

3 J8108] The expandable support devices 2 can textured and/or porous surfaces for

4 example, to increase fricϋon against bone surfaces, and/or promote tissue ingrowth. The

5 expandable support

Figure imgf000016_0001
2 can be coated with a bone growth factor, such as a calcium

6 base.

7 [ø ϊ 09j The expandable support de\ see 2 can be covered b\ a thm metal screen, for

8 example over at least the top and/or base ports. The thin metal scieen can expand and/or

9 open when the expandable support device 2 expands

10 \Q\ 10] Any or ail elements of the expandable support device 2 and or other devices or

11 apparatuses described herein can be made from, for example, a single or multiple

12 stainless steel alloys, nickel titanium alloys (e.g , Nitmol). cobalt-chiome allots (e.g ,

13 EL<jlLOY-J<x from Elgin Specials Metals, Hlgm, IL; CGNICHROME^ from Carpenter

14 Metals Corp., W) omissmg, PA), nickel-cobalt alloys le g , MP35N £ from Magellan

15 Industrial Ttading Company, lnc , Westport. CT), molybdenum alloys (e g., molybdenum 1 o TZNl allo> . to* example as disclosed in Internationa! Pub. No. WO 03 082363 A2,

17 published 9 October 2(503, w hich is herein mcorporaled by reference in its entirety),

IH tungsten-rhenium, alloys, for example, as disclo&ed m International Pub. No. WO

IV o3''OH23f>3s polymers such as polyelliyletie teraphathalate (PET)φoiyesιer (e.g.,

20 DACRONsF' from b. 1 Du Pont de Nemours and Company. Wilmington, DL),

21 polypropylene, (PFT). poiytetrafltjoroethylεne (P TFb), expanded PI l-F (ePTF F), 2 poh-ether ketone (PEK), polvether ether ketone (PBtK), poly ether letcme ketone 3 (PhKK) (also poly aryl ether ketone ketone), nylon, pel) cthcr-block co-poiyarmdc

24 polymers (e g.. PEBAXK fiom ATOFINA Paris, France), aliphatic polyethβr 5 polyurethanes (e.g., TECOFLEX^ from Thermedics Polymer Products, (> Wilmington, MA), ρol> \ my! chloride (PVC), polyurethatϊe, thermoplastic, fluorinaied 7 eth> leue prop) lene (FtP), absorbable or resorbable pol> mers such as polyglycolic acid 8 (PGA), polylactic acid (PLA), pohcapiolactone (PCl.), poK ethyl acn Sate (PEA) 9 polydtoxanone (PDS) and pseudo-poiyarcuno tyrosme-bisscd acids, extruded collagen, 0 silicone, /me, echogemc.

Figure imgf000016_0002
radiopaque materials, a biorøatenal (e g.. cadaver t tissue, collagen, allogiaft. autouraft. xenograft bone cement morselled bone, osteogenic 32 der, beads of bone } anj of the othet materials listed herein or eoitibiiutiυns thereof 1 Examples ui radiopaque materials ate barn m sulfate^ /tnc ovsde ttiamum, btamiess steel

2 nickel- titanium alloys, tantalum and gold

3 |81 I I] Any or all elements of (he expandable device 2 and oi other

Figure imgf000017_0001
tees or

4 appatatuses described herein, can be.

Figure imgf000017_0002
and/or be completely oi paniaih coated with

5 agents and or a malax a maϋix foi cell mgrowih oi used with a fabiic, foi example a

6 eøiermg (not shown) that acts as a

Figure imgf000017_0003
for cell ingrowth The malm and or fabnc can

7 be, lot example, po!> estei (e g.. DACRON H Dora E I Du Pom de Nemouis and

8 Oowpauv , Wilmington. DE },

Figure imgf000017_0004
ePTTE,
Figure imgf000017_0005
ion, exuuded collagen, l> silicone or combinations thereof

10 pi 12] F he expandable support de\ see 2 artior element of the expandable support

11 2 and/or oilier de\ ices or apparatuses descubed herein and oi the fabnc can be

12 filled, coated, ia\ ered and or othct w ise made \\ ύh ARU or from cements ftilers, giue^

13 and or an agent deln erv man ix know n to one

Figure imgf000017_0006
mg oidmaiy skill in the art and or a

14 therapeutic and OJ diagnostic agent λn> of these cements ami/or fillers and or glues can

15 be osteogenic and osteomducti \ e giowih factors

10 |0113] of »uch cements and oi fillers mcrudes bone chips de-minerab/ed bone

1 "* mattiλ (DBMj, calcium sulfate, coralline li>

Figure imgf000017_0007
biocoral, tncalcuim phosphate,

1 K calcium phosphate, poh methyl methaci ylate (PMNΪΛ). biodegt adabk cei araics, bioactn e iy glasses, ϊwaiiuoruc acid, lactofetuπ, boue UKiiphogeotc piotems ( BMPs) such as»

20 recombinant human bone morphogcnelie protcms. (rhBM Ps), other materials described

21 herein, or combinations thereof 2 |0 ϊ Ϊ4[ fhe ayems withm these raatuces can uiciude an> agent disclosed he; em or ^ combinations thereof, including radioaciπ e materials, ladiopaque mateuaK, c\ togcntc 4 agentN, cytotoxic agents, cytostatic agents, thrombogenic agents, for example 5 pol>urelhane. cellulose acetate poh mer mixed vt ith bismuth tπoKide. and eth\ lene \ m 1

26 alcohol iubπuous, hvdiophihc lπateπais. phosphot tholetie

Figure imgf000017_0008
agents,

27 foi example non-steroidal anti-mfiammatones (XS AIDs) such as cvcSooλvgeikisc- i 8 (COX-D inhibitors (c g , a

Figure imgf000017_0009
cet\ acid, for example A.SPSRI\ RN fiom Ba>ei AO, () Lev eilα&ωi, Gcimanv. ibupiufen for example AD\ Il 4< from W yeth, CoIi ege\ JΪie. PA, 0 mdomcthacm, mefeiianiic acid), COX-2 aihώitots (e g , VSOXλ fc fiom Merck &. CQ , 1 liic . Whitehonse Siatsnn, Nj, CELtBRfc\κN fiom Pharmacia Corp , Peapack, NJ, COλ-i 2 inhibitors);
Figure imgf000017_0010
\M U NH ^ from 3 Wvetii
Figure imgf000017_0011
P \) or matrix metailoprotemase (MMP) inhihiton {& g

34 tetracycline and tetracycline donatives) that act earl) ^ tth«i the pathways of an 1 mπammutof} tεsponsε FκampU:s of oihei agents aie pπnsded in Walton e! ai. Inhibition

2 of Prostoglandm F> Sy nthesis m Abdominal AotUc Aneiitvsros, Circulation, Jttij 6 \9Ψ) T1 4,s»54 Iambiah et ai, Provocation of Experimental Aortic Inflammation Mediators and

4 Oilam>dia Pneumoniae, Brit J Swxen 88 {,"?), 935-*->40. Ftankhn « aL Uptake of

5 Teuacyeltne bv Aortic Aneurvsni Wall and Its Effect on fnlknimauon and Ptoteol>sis,

6 Brit J Surgi'nΗCf (6),

Figure imgf000018_0001

7 m Hypoxic Vasculat Endothe! turn, J Biological ( 'hem^ ity 275 (32 } 245S3-245K1) , and

8 Pvo el ai. Tasgeied (ϊene Disruption of Matπx Nfetal!opjoιeinase-V> (Gelatinase B)

^ Suppresses Development of Experimental Abdominal Aorue Aneurysms, ./. ( lniicat

10 Inveiftgation 105 ( J ] ), 1 (A 1 - i hΦ> which are ai I incorporated by reference m their

11 entireties

12 fθllSj The expandable support

Figure imgf000018_0002
ices 2 can be iases cut, machined, cut by v, ste

13 electrical discharge machining ("JbDM") or made by other suitable techniques I he

14 expandable support de% ice 2 can be cut in u foil) contracted CM unexpanded configiualion

15 or nia\ be cut in a partial! v opened pattern, then loaded (e g , CJ imped) onto a deployment 10 tool i 32 (e s balloon 1 "U) The loaded expandable support

Figure imgf000018_0003
2 can hare a smallci

17 profile while plastically deforming the struts H' past their limits

IH \§U6] The expandable Nippon device 2 can be louguudmαli> segmemed Multiple iv expandable suppoi t de\ ice^ 2 can be attached fit st end 4 to second end O, and or a single

20 expandable support device 2 can be sexered iongtttidinallv into multiple expandable

21 support devices 2 3 Mh I HOD OF LSh 4 [8117] Figure 8 illustrates that the expandable support

Figure imgf000018_0004
ice 2 can be loaded m a 5 collapsed O e . contracted) configuration oMo a depio> mem tool 132 1 he depio) mem

26 tool 132 can be configured to rermnablv attach to the fust side tamp and the second side 2n tamp One nr more deployment iooK can be configured to control the position of the 8 expandable support device (e g,, to rigidly attach to the expandable support dc%icej and or () to longitudinally eomptess the second side ramps., and ox to deploy one or mote locking 0 pins iti the expandable suppoit

Figure imgf000018_0005
ice The
Figure imgf000018_0006
meet tool can include a rigid OJ 1 llexϊble catheter 136 2 |0118j Figure 9 illustrates that the deployment tool can longitudinally compress the 3 expandable support, deuce for example causing the eλpandable support device to

34 \ erticalh expand

Figure imgf000018_0007
1 J0Ϊ Ϊ9| Psgutes 10 (side
Figure imgf000019_0001
column 140 that can

2

Figure imgf000019_0002
tebra 142 b\ discs 144 1 he

3 x crtebra 142 can have a damage site 146, for example a compression iractoe

4 $120] Λα access tool 148 can be used to gain access to the damage sjte 146 and OΪ

^ met ease the we of the damage sue 146 to aikm deployment of the expandable suppoit

6

Figure imgf000019_0003
ice 2 ϊ he access, tool 148 ςaii be a rotating oi \ ibiatmg drill 1 %) that can e a

^ handle 152 Optionally, the dull 150 ma> oscillate, as show o b> arrow x 154 The di ill

8 15o can then be uauslaied, as shown

Figure imgf000019_0004
towαtd and mto the veiiebia 142 so as

9 to pass into the damage site i 46

10 pi2I] Figure J2 illustrates thai the access too! 14K can be ftanshited as shown h\ amn\

11 118 to e tissue at the damage sue 14f> The access tool 148 can eieate an access

12 port ! 60 at the surface oi the \ ertebra 142 The access pon 160 am open tυ ihc damage 1

Figure imgf000019_0005
the 142

14 [Θ122f hgiue I^ iliustiates that a first deployment tool 162 can enter posterior \y ihrough

15 the ^ubjett's back The fhs>t dcpknmeiu too! 162 can entet thtougli a lust uicistion 164 in

16 the 4UΠ 166 on the posicπoi side 167 of the subject scar the

Figure imgf000019_0006
column 140 The

17 first depiovment tool 162 can be translated, &> show n b> aiiow 168, to portion a first

1 H expandable support

Figure imgf000019_0007
ice 4(i into α fust damage sue 170 The fust access pos t i ?2 can

1 v be on the postet ioi side 1 ft? of the s erlebi a 142

20 {0123J A second depioxmeni tool 1"4 can enter ihrough a second mciSion ! 76 {as shoun)

21 m the sktn i 66 \ he second mcision. 1 ">(■>

Figure imgf000019_0008
be posterior (as show n > or mav be antcπoi 2 lateial poiteπot lateial ot the kke lhe second depiosraem too! 174 can be Mandated 3 thtou^h muscle (not srκπ\ nl, aiound nent^ i 78, the spinal cord 180, and anlenor I S2 of 4 the column 140 The second deployment tool 174 can be steetable ϊhe second "> deployment tool 174 can be sieeied as shoAii b> arrow 184, to ahgn the distal tip of the 26 second expandable buppott
Figure imgf000019_0009
tee 46 v, jth a second access port 1 £6 on a second damage 2*1 site 1 W The second access port 186 can face anteπotlv iH2 The second deplo\mem 8 too! J 74 can translate, as shown b> arrow 190 to portion tlic second expandable support () tec 46 m [lie second damage sue 18S

30 JOl 24] As illusUatαi, the \ etteka ! 42 can

Figure imgf000019_0010
multiple damage sites and expandable 1 siippoil
Figure imgf000019_0011
deptoved tlierein I he expandable suppos i
Figure imgf000019_0012
can be deploj ed fiom 2 {he ameπoi 1^2 posteπoj 167, both lateral, superiυr inferior any angle oi combinations ^ ^ of the directions ώeteoi Ol couise. a ssrsgle des ice ma> be deplos ed koni one dst ectrøi ^4 nither than multiple de\ ices, from multiple directions 1 J0Ϊ25| Figutεs 14 ami 1 ^
Figure imgf000020_0001
iliusiiate uaubhu ng ai» b\ aiiow ihe depkn men. iool

2 1

Figure imgf000020_0002
2 through the accos port S 60 from the

3 ante) tor

Figure imgf000020_0003
\ eπebral column i 40 Figures 1 d and 17 illustrate that the

4 ment tool 13- can be deployed ! torn the postetioi Side 167 ol the

Figure imgf000020_0004
column

5 140 The deplo\menι tool 132 can be deploved off-cemei. for example, when

6 appi oachmg the posterior side I <V7 of the \ β£ tebϊ al col u mn 140

"7 [0 ( 26f Figuie I X illubtiates thai deploy meitt tool 132 can position the expandable suppui t

8 2 in the

Figure imgf000020_0005
142 and into the damage site 146

9 J(Jl 27] Figure ! 9 illustrates thai the expandable support de\ ice can be longif tulmalh

10 compressed

Figure imgf000020_0006
2 is

11 substantial!) fixed to the \ ertehia 142 The expandable support de\ ice 2 can ieshape the

12 \ ertebr al column 140 to a mot c natural conff gut ation duung expaπbioπ of the

Figure imgf000020_0007
tee

13 [0 f 28| tigui es 20 and 21 illustiate that fit sf and second deployment tools 162 and 1 "4

14 can position and depio> first and second expandable suppon devices 40 and 46

15 simultaneously and oi m the same \ eitebra 142 and into the s»aiτιc oτ dtffcient damage 10 Mies 170 and I RR

17 J0129) Figure 22 illustrates tliat the access pon 160 can be made ciobc to the di->c 144 for

1 H example w hen the damage site 146 is close to the disc 144 The deplo>raeπt too! 132 can iv be iaseited tluough the access pon ! 60 and the expandable suppoti dev ice 2 can be

20 deployed as described supra

21 [Θ13O| Figure 2 ϊ a front \ ιew of the vertebral column 140, illustrates that more than one 2 expandable support de^ ice 2 can be deplo\ ed into a single \ ertebra 142 For example, a 3 fii st expandable support

Figure imgf000020_0008
ice (not show n) can be inserted through a fii st access pot t 4 172 and deplo\ ed in a first damage site 1 "7O, snd n second expandable support de\ ice (not "> show n) can be mseiied thiough a lust access pon 172 and deployed in a second damage 26 sue 188

2n [013 ϊ J The first access port 172 can be substantially ccmcied with iespect to the first 8 damage site 1 "1O The first expandable Mirφoit dc% ice f not shownj can expand, a^ ^hown () arrows 64. aibstantiallv supeπorh and snteπotK. alι»ned with Ae center of the first 0 access port 172 The second access pon 1 bύ can be substantial not centered with 1 iespect to the second damage sue I *tø llie second expandable siφpoit ctes ice can 2 substantially anchor to a side of the damage sue 146 and or the suiface of the disc 144. 3 and then expand, as skmn by α

Figure imgf000020_0009
uo^s w), substαjn»ai!> awa> from the ώse H 144

V) 1 jøt J2| Psguie 24 illusttiatcs tiiat \\ iieu compιess>n e tension frυin the deplo> meπt tool ts

2 no longer exerted on the expandable suppoi dc\ice the expandable support dex ice can be

3 self-locking and or a fixation pin can be mseited before during or alter the

Figure imgf000021_0001

4 tension ϋ> stopped The expandable support

Figure imgf000021_0002
see can then be substantia!! v fixed to the
Figure imgf000021_0003
support tee can be 6 subject to biomeehanical compression w ithm one oi betv\ een tuo \ enebrae

^ [0I33J The access puit 160 can h,ne an access poit dsaraeiet rø The access port

8 diametei 392 can on from about i 5 mm ψ 060 m ) to about 40 mm (2 JO ), An example

9 about K mm (0 3 in } The access poH diameter ll)2 can be a result of the si/c of the

10 access tool 148 and in the uncxpanded expandable support

Figure imgf000021_0004
2 After the

11 expandable support

Figure imgf000021_0005
ice 2 is deploved, tiie damage sue 146 can ha\ e a
Figure imgf000021_0006
ed

12 diameter 194 The deployed diameter 194 can be from about ! S mm (0060 in ) to about H i 20 mm (4 ~* m ), for example from about 10 mm (04 m ) to about 20 mm (0 8 m ) oi

14 from about 12 ram (04"? m ) to about 16 mm (0 6"? »i ) 1 he deployed diametei 194 can

15 be grealeϊ than, equal to oi less than toe access port diameiei !92

16 JΘ134] Figure 25 illustrates that the deployment tool I >2 can be removed, <is shown

17 fi ØIΪI the \ erteHra 142 after the expandable siippoϊ i dc\ ice 2 is deploved

1 H (0135) Figure 26 illusUates that the expandable support

Figure imgf000021_0007
ice 2 can be loaded onto the iv deployment tool 132 The expandable suppoit device 2 can be positioned adjacent to the

20 disc 144 [he disc 144 can be between a first vertebra 142a and a second \ ertcbra i42b

21 [βl36| Hgure 27 illustrates thai the expandable suppott device 2 can be inserted nno the 2 disc 144, foi example mto the nuclear space or into the annular space Remo\ al of none, 3 pan ot all of the nucleus and oi annul us tan be performed before placing the expandable 4 suppoϊt

Figure imgf000021_0008
ice 2 in the disc 144 "> (0137) Figure 2s: illustrates that the expandable suppou
Figure imgf000021_0009
ice 2 can be sadtaSK

26 expanded, as show n b> arrows, m the space of the disc 144 Rough

Figure imgf000021_0010
jπgtowth

2n matrix teeth, or combinations theicoi'on tiie top ot bottom of the expandable vuppoit 8 deuce 2 can engage the first oi secon i 42a or 142b oi both The expandable () .support

Figure imgf000021_0012
ice can fuse oi fix the lust
Figure imgf000021_0011
42a to the second
Figure imgf000021_0013
142b The

30 expandable support de\ ice can increase the gap

Figure imgf000021_0014
the lϊisi \ ertcbra S 42a and the 1 second x ertebra 142h ( e g , to restoie propei or OJ igmai biomechanics and or anatomical 2 geometn ) 1 J0Ϊ38J Psguie 29 illusttiatcs that the deployment tυυl \ ^2 coil be disconnected from the

2 expandable support de\ ice 2 1 he depioyinent tool \ i2 can be rεmo\ cά Horn the space of

3 the disc 144 with or \\ ithout the expandable support dev. see 2

4 [0139] Figures K) thiough 33 Ulissttαte a method of d

Figure imgf000022_0001
epio\mg the ofthe
Figure imgf000022_0002
2 Figure 30 illustrates thai the expandable sυppυi I
Figure imgf000022_0003
2

6 can be attached to the deploy meet tool H2 ϊhe expandable iuppoit

Figure imgf000022_0004
2 can be
Figure imgf000022_0005
a 142

8 figuj e 31 illustrates that the deployment tool 132 can tt an si ate and totate the expandable

9 support

Figure imgf000022_0006
ice 2 to the target site Hgure 32 illustrates that the expandable support

10 de\ tee can be kmgmiώnally compressed and radialh expanded, as show n b\ arrow s

11 Figuie 33 iliustiates that the deplo> meat too! B 2 can Be sepai ated fiom the expandable

12 suppoit deuce 2 The deplojmcni tool 132 can be removed from the target sue The 1

Figure imgf000022_0007
or

14 [Oi 4Oj hgιue:> 34 and 35 tiiusuate that a locking pin 1% can be inserted, a^ shown b>

15 aiiow uuυ the deployed expandable support

Figure imgf000022_0008
ice 2, for example after the expandable 10 support
Figure imgf000022_0009
ice 2 is deployed in the vertebra 142 The 'ockmg pm 1% c<in prevent the

17 expandable support

Figure imgf000022_0011
2 from
Figure imgf000022_0012
aftei the expandable support
Figure imgf000022_0010
2 is

1 H deplo} ed in the \ ertebra 142 The locking pm I % caa lbs m an mtei {ensαce Ot w ith the iv expandable suppoj t de\ ice 2 or may include featωes to hήύ the locking pm m place

20 pi4ϊ J Figures ^6a illustrates that one, two or more de\ ices 2 such as a first device 2a

21 and a second

Figure imgf000022_0013
2b, can be inserted, depkn ed and or implanted the targes sue, such as 2 in a \ ertebral bod} 324 or oo a \ eriebia) bod\ 324 (e g between adjacent \ enebral 3 bodies) ϊhe dex ices 2 can be oriented so the longitudinal axes 4 of the deuces 2 cue 4 substantial!) paialle! \\ Hh an anteπor-postenor axis MO oi the patient "S (0142) 1 he fust
Figure imgf000022_0014
st longitudinal axis 4a can be

26 MΛκLsnπally paialld with the aτitenυj-poskteτiot &\ιs >2U

2n |0i43| The second

Figure imgf000022_0015
2b can be oncnicd so the second
Figure imgf000022_0016
ice longitudinal axts 4b 8 can be
Figure imgf000022_0017
2b () can be positioned m a substamialls vssmrae'iic location and anguiai ouentation to the first

30 de\ ice 2a w ith respect to the antetior-postcriot axis 320 1 {01441 l he coπcaxnv ofthe rødsus of cunature 54 of tlie deuce can lace tow aid (as 2 shown} or av*a> fiøm the medial direction (i e , the eenti al aateπoi-posteπoi axis 32!»)

33 {0145) Λftei placed into position at the taiget site the deute 2 can be longitudinally

M eontuUed and radiaih expanded h or example, as shown, the second

Figure imgf000022_0018
has hc>in

2i 1 rαdialH expanded and the fust device 4a has beets delncied to the tmaet stte and not vet

2 radialH expanded Multiple deuces 2 can be delπeted tonαnrentlv oi seqitcnualiv i Multiple deuces 2 can be ladiallx expanded sequential! v or cnncinrenth

4 [0146] The

Figure imgf000023_0001
2 can be mseued w αb a surgical technique such as an Antenor

5 Lumbal lrueibod> fusion (ALIF), shown

Figure imgf000023_0002
arrow 322a, Posieuot Lumbal {ulerbodv

6 Jhu&ion (FLIF), shown bv attow 322b, \ rarfeibrammal Lumbar Meϊbody Hision ( TLIF), ^ show α b> an ovi 322c a duect hneat lateral delner>, as» shown b> arrow 322d, a

8 eumluieai iateiai deiπen mitialis inserted postenotiv, as shown bs at tow 322e, ot othet

9 methods or combinanoni thereof

10 pi47] Operate e planning and icmpiaung cart be performed ifcing MRi and C \ T

1 1 imaging scans to Ueteimme

Figure imgf000023_0003
ice fits the patient's anaioim and
Figure imgf000023_0004

12 [Θ148J The dnc O e

Figure imgf000023_0005
Uu get ^ite utiuhcn be prepared Fof 1
Figure imgf000023_0006
\ eitebrae can be accessed thioυgh an mcision HI the paueni s back

14 (i e , po^ienor to the %eitebrαe) Depending on the numbei of \ ertebi ai levels to be feed

15 about a "*-6 inch musion can be made in the patient's back The spinal miisciεs taa then 1C' be retracted (or separated) fot example to allow a

Figure imgf000023_0007
ccc^ to the tat set discs The 17 lamina uiπ then be rcmo\ ed (t c , a ianimettom> ), for example Io be able to sec and

1 H access the mi \ e loot;. The facet loints, w hsch can he direct K OΛ ei the «es \ e ϊoots, can iv be mmmed, foi example, \o Mow more room ioi the neπe roots The target disc and

20 surrounding tissue can then be remosed imi the bone surfaces of adjacent

Figure imgf000023_0008
can

21 be prepared (e g , cleaned abraded, debnded textured scored, toatcd with osteogenic 2 pow ders oi other agents OJ combinations thereof) 3 JΘ149] fhe

Figure imgf000023_0009
sees 2 can then be mooned into the target site One or mojc
Figure imgf000023_0010
sees 2 4 and oi bone graft {c c , autograft allograft,
Figure imgf000023_0011
BMP oi eombmaUons iheicof, "> can be mseiteά into the target site or disc space, for example to piomote fusion bem een 26 ihe seitebuie Additional Jiistiumeiitation ^e g rods oi suews>) can also be used at llits 2n lime to turthe* stabih/e the spine 8 j(i!50{ TLiI- can include dehvenng the dexitc 2 to fhc spme in a path more from the wdc () of tlie spmal canal than a PI IF appioach and throimh a midline incibfon HI the patient b

30 back TLlF can reduce the amount of sυigica! muscle dissection nnά can tninmii/cs ΏCΪ\ e 1 manipulation required to access the \ ertebrae, discs and nenes 2 {0151 J I Lϊϊ- can include leraox ing disc mates ?al from the spine mά inserting the ^ deucet^ and bone i-iaU BMP sctews tods ot combination* thereof 1 J0Ϊ52| AUF is pei formed inserting the flora the ftont lanteaυr) of the bods usually

2 fhtough a

Figure imgf000024_0001
\WΛ\

3 im oh c cutting through and later lcpantng ώe muscles m the lower abdomen

4 [0153] Λ rami open ΛLIF approach can bepeifouυed A mini open ALIF can

Figure imgf000024_0002

5 the muscles and allow access to the iϊont o^the spine thiough ΛΏ incision This, appioach

6 maintains abdominal muscle strength and function and can be used lo fuse the L^-Sl disc

7 space , lot example

8 jøϊ 541 Once the iucisiou is made and the \ ertebrae aie accessed, and afles the abdominal l> muscles and blood \ easels ha\ c been tetracted, the disc materia] car) be rcmm cd 1 he

0 O surgeon can then insert the

Figure imgf000024_0003
sees 2 and or bone graft, rods, screw s BMP, or

11 combinations thereof, for example to subtls/e the spine and facilitate fusion

12 [9155J The target sue (or the

Figure imgf000024_0004
icc(:») 2 CLΠ be between sacral, inmbai thoracic ceuicai

13 or combinations theieof The iaiget site can be between other bones, such as

14 intercostal (betw eeπ nbs) m the knee, eibom , w πst. ankle, or combinations thereof

15 jθi56| Fsguie

Figure imgf000024_0005
2 tan be inserted into Ut the target sue such as m a
Figure imgf000024_0006
bock or on ά xertcbia! bod^ (e g , between adjacent 1 "* x enebral bodies) 1 he longitudinal
Figure imgf000024_0009
4 of the
Figure imgf000024_0007
2 tan be ot iented
Figure imgf000024_0008
IH peφendicuiar to (he anteπoi-posteuo! aλis 320 M e , paiailel to a lateial axis) The iy conαn ύ\ of die iadius of cm vaiure 50 can face anteuotiv ot posteπotiv

20 |0l57j 1 be de\ ice 2 tan be filled v\ ith a filled before or after radial expansion Tissue

21 ingrowth can occur into the top plate through {he top ports bottom plate through the 2 bottom ports, and elsew here through the

Figure imgf000024_0010
3 ((Jl 58] PC I Application No L S20<^ 034,728, Publication Ko WO 2006 (W>8,ό82,

24 entitled 'Fxpandable Sυppott ϊ)e\ see and Method of Use" filed 26 September 200^ and 2"! U b isional Patent Application No 60 612 728, filed on 24 Sepiembei 2004, are

26 herein uicυipoiaied

Figure imgf000024_0011
iefeience in then eniaeties

27 [0l5θ| It is apparent to one skilled m ihc ait that \atious changes and mυdiilcations can 8 be made to this disclosure, and

Figure imgf000024_0012
departing fiorn the spirit () and scape of the uneiition Flcmcπis .shown with anv v ariation ate everaplmy far die

30 specific \ aπation and can be used on othci \ aπatωπs v\ uhin this disclosure Any

31 elements described herein as singular can be pUirali/ed {i e , an> thing described as ' one"

32 can be more than one) Any species element of a genus element can has e the

33 ehaiaclemtics or elements of anv othei species dement of that genus The M described conilgurations, elements oi complete assemblies and methods and their

2^ elements foi earning out the invention, and variations of aspects of the invention can be combined and modified with each other in any combination

Claims

1 CLAIMS
2 We claim
3 I An expandable orthopedic implant comprising
4 a first lαad-beanng element
5 a second load-beat ing element,
6 a sliding element Uidably attached to the first load-beanng element and the second "7 load-beaimg element, wheietn the sliding element has fust, second and third sliding
8 element ramp positioned substantial! v
Figure imgf000026_0001
disti ώuted along the length of the sliding
9 clement and wherein the first load-hearing element has a litst second and third load- It) bearing ramp features, and wherem the first second mid third sliding element ramp
11 features are configured to press against the first, second and third ioad-beai ing iamp
12 features, respectively , when {he sliding clement is tunsϊated vuih iespeci to the fust load-
13 bearing element, and u hetem the ttanslation of the sliding element w ith respect to the
14 fast load-bearing element causes the first load-beaπng element to
Figure imgf000026_0002
from the
15 second load-bearmg element.
1 C' wheiem the device has iadins of curvature, and wherem the radius υf cur\ .nitre is
17 not infinite and non-/ero
IH
IV 2 The of Claim I, svhereui the first sliding element t amp featute has a fust tooth
20 configured io tύlow unidirectional sliding against the first load-beartng element
2 ! 2 5 ϊ he de\ ice of Claim 2, w herein the second wedge has a first losd-bearm^' tamp ieatme 3 is configured to allow unidirectional sliding agamst me first sliding element 24
2"> 4 The device of Claim 1. funhei comprising a locking pin
26
2n 5 The ice of Claini 4, wherein the locking pin is attached to the first load-beanng 8 element ()
30 f> The dc\ ice of Claim 4, whet em the locking pun is attached to the sliding element
31
32 η The ύt\ ice of Claim 1 , wheieui the radius of cars atiue is constant along a longiuidnial
Figure imgf000026_0003
34
2^ 1 8 Tlie άc\ ice uf Claim ! \s heteiu the radium of cut \ a Line v <mes> along a longitudinal
2 length of the
Figure imgf000027_0001
ice
4 v The deuce of C faun ! wheieni ibe tadius of cnruitute ^ gieater than aboia 0 ς m and
^ ϊe«vs than about 3 m
6
7 i 0 Λa expandable orthopedic implαm
Figure imgf000027_0002
longitudinal axts compt tsing
8 a f ifsi ioad-beai ing element l> a second Ioad-beai ing element
10 a
Figure imgf000027_0003
element shdabh attached to and between the fits! Soad-ht'aπng element
11 and the second load-bearing element and wheiem the tiansiation oi the sliding eiemem
12 w uh iespeci to the fii st load-beat ing element causes the Hist loαd-bearsng clement to 1 aw av fiom the second load-bearing element
14 w heiem the longitudinal
Figure imgf000027_0005
hai radius of cυnatiue and
Figure imgf000027_0004
fee tadius of
I s* mi \ dtuie is not infinite and noiweio
10
17 H A method for supporung an mfen ertcbral target wtc bet een a first xertcbra and a
1 H second \ a tebra compx jsmg iv itfoeitmg a device having a longitudinal avis mto the target site, wheiem the
20 device comprises a first ioad-beaung clemtnt, a second load-bearmg element and a
21 sliding element and w herein the sliding element is attached to the fitst load-bearing 2 element and the second load-beaπng element and w herein the longitudinal axis has 3 iadrus atuie, and herein the udius of cunaiure is not infinite and noiwero
24 traiiNlating the sliding element u ith
Figure imgf000027_0006
to the first load-beaπng clement 2">
Figure imgf000027_0007
awa\ fiυm the 26 second load-beaung element
2n contacting the fust icitebia
Figure imgf000027_0008
the fits! load-bearing eleraen., and 8 tontactmg the second \ ertebra ^ iSJb the second load-beαi ing element
PCT/US2010/038857 2009-06-16 2010-06-16 Expandable support device and method of use WO2010148112A1 (en)

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