WO2010144814A3 - Particle sorting using fluid streams - Google Patents

Particle sorting using fluid streams Download PDF

Info

Publication number
WO2010144814A3
WO2010144814A3 PCT/US2010/038332 US2010038332W WO2010144814A3 WO 2010144814 A3 WO2010144814 A3 WO 2010144814A3 US 2010038332 W US2010038332 W US 2010038332W WO 2010144814 A3 WO2010144814 A3 WO 2010144814A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
fluid streams
particle sorting
channels
processing chamber
Prior art date
Application number
PCT/US2010/038332
Other languages
French (fr)
Other versions
WO2010144814A2 (en
WO2010144814A9 (en
Inventor
Zheng Xia
Tania Chakrabarty
Haojun Fu
Dan Mueth
Original Assignee
Arryx, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arryx, Inc. filed Critical Arryx, Inc.
Publication of WO2010144814A2 publication Critical patent/WO2010144814A2/en
Priority to US13/007,176 priority Critical patent/US20110177547A1/en
Publication of WO2010144814A3 publication Critical patent/WO2010144814A3/en
Publication of WO2010144814A9 publication Critical patent/WO2010144814A9/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B01L2200/0652—Sorting or classification of particles or molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/16—Surface properties and coatings
    • B01L2300/168—Specific optical properties, e.g. reflective coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0454—Moving fluids with specific forces or mechanical means specific forces radiation pressure, optical tweezers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0638—Valves, specific forms thereof with moving parts membrane valves, flap valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components

Abstract

A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a motive force such as optical trapping into a collection channel. Once in the collection channel, particles can be collected, including by trapping in a porous matrix.
PCT/US2010/038332 2004-12-10 2010-06-11 Particle sorting using fluid streams WO2010144814A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US13/007,176 US20110177547A1 (en) 2004-12-10 2011-01-14 Particle Sorting Using Fluid Streams

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18682509P 2009-06-13 2009-06-13
US61/186,825 2009-06-13

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/298,565 Continuation-In-Part US7875845B2 (en) 2004-12-10 2005-12-12 Automated extraction and purification of samples using optical tweezers

Publications (3)

Publication Number Publication Date
WO2010144814A2 WO2010144814A2 (en) 2010-12-16
WO2010144814A3 true WO2010144814A3 (en) 2011-04-14
WO2010144814A9 WO2010144814A9 (en) 2011-06-03

Family

ID=42989580

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/038332 WO2010144814A2 (en) 2004-12-10 2010-06-11 Particle sorting using fluid streams

Country Status (1)

Country Link
WO (1) WO2010144814A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10371622B2 (en) 2013-03-14 2019-08-06 Inguran, Llc Device for high throughput sperm sorting
US9757726B2 (en) 2013-03-14 2017-09-12 Inguran, Llc System for high throughput sperm sorting
US10662408B2 (en) 2013-03-14 2020-05-26 Inguran, Llc Methods for high throughput sperm sorting
CN105829865B (en) * 2013-09-05 2018-12-04 伯乐生命医学产品有限公司 On-demand particle distribution system
US10343165B2 (en) 2013-09-05 2019-07-09 Bio-Rad Laboratories, Inc. On-demand particle dispensing system
EP3748332A4 (en) * 2018-01-30 2021-10-27 Kyocera Corporation Inspection flow channel device and inspection apparatus
US10940477B2 (en) * 2018-07-19 2021-03-09 Micareo Taiwan Co., Ltd. Fluid sample collection and retrieval apparatus and microfluidic chip

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837115A (en) * 1993-06-08 1998-11-17 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US20060134603A1 (en) * 2004-12-10 2006-06-22 Arryx, Inc. Automated extraction and purification of samples using optical tweezers
US20080290037A1 (en) * 2007-05-23 2008-11-27 Applera Corporation Methods and Apparatuses for Separating Biological Particles
US20090075826A1 (en) * 2007-09-13 2009-03-19 Arryx, Inc. Methods and apparatuses for sorting objects in forensic DNA analysis and medical diagnostics

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7976795B2 (en) 2006-01-19 2011-07-12 Rheonix, Inc. Microfluidic systems

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5837115A (en) * 1993-06-08 1998-11-17 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
US20020160470A1 (en) * 2000-11-13 2002-10-31 Genoptix Methods and apparatus for generating and utilizing linear moving optical gradients
US20060134603A1 (en) * 2004-12-10 2006-06-22 Arryx, Inc. Automated extraction and purification of samples using optical tweezers
US20080290037A1 (en) * 2007-05-23 2008-11-27 Applera Corporation Methods and Apparatuses for Separating Biological Particles
US20090075826A1 (en) * 2007-09-13 2009-03-19 Arryx, Inc. Methods and apparatuses for sorting objects in forensic DNA analysis and medical diagnostics

Also Published As

Publication number Publication date
WO2010144814A2 (en) 2010-12-16
WO2010144814A9 (en) 2011-06-03

Similar Documents

Publication Publication Date Title
WO2010144814A3 (en) Particle sorting using fluid streams
WO2009117611A3 (en) Trapping magnetic cell sorting system
WO2010040851A3 (en) Microfluidic multiplexed cellular and molecular analysis device and method
GB2464433A (en) Trapping magnetic sorting system for target species
WO2011075667A3 (en) Biologic fluid analysis cartridge
WO2012119243A8 (en) Method and system for portable cell detection and analysis using microfluidic technology
WO2006086620A3 (en) Method for fluid sampling
MY170587A (en) Centrifugal micro-fluidic device and method for immunoassay
MX2010005571A (en) Environmental sampling articles and methods.
WO2014152048A3 (en) Assemblies and methods for reducing optical crosstalk in particle processing systems
WO2010065967A3 (en) Microfluidic-based lab-on-a-test card for a point-of-care analyzer
WO2007092586A3 (en) Blood collection device, method, and system for using the same
WO2007146429A3 (en) Portable discrete groundwater sampling system
WO2009152094A3 (en) Hubbed dual cannula device for closed container sampling systems
WO2010033140A3 (en) Removable/disposable apparatus for mems particle sorting device
WO2012162181A3 (en) Analysis and sorting of motile cells
EP2796854A3 (en) Micro-lens systems for particle processing systems
SG138529A1 (en) A method and unit for preparing a sample for the microbiological analysis of a liquid
WO2010123594A3 (en) Device for filtration of fluids there through and accompanying method
SG170703A1 (en) Microfluidic system for detecting a biological entity in a sample
WO2009125092A3 (en) Device for aliquoting and filtering blood
WO2008060713A3 (en) Flow cytometry methods and immunodiagnostics with mass sensitive readout
EP3150702A3 (en) Devices, solutions and methods for sample collection
WO2007051170A3 (en) Apparatus and method for improved optical detection of particles in fluid
WO2009075764A3 (en) Methods and apparatus for analyzing samples and collecting sample fractions

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 2010723470

Country of ref document: EP

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10723470

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10723470

Country of ref document: EP

Kind code of ref document: A2