WO2010131955A1 - Intraocular lens with variable shift - Google Patents

Intraocular lens with variable shift Download PDF

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Publication number
WO2010131955A1
WO2010131955A1 PCT/NL2010/050270 NL2010050270W WO2010131955A1 WO 2010131955 A1 WO2010131955 A1 WO 2010131955A1 NL 2010050270 W NL2010050270 W NL 2010050270W WO 2010131955 A1 WO2010131955 A1 WO 2010131955A1
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WO
WIPO (PCT)
Prior art keywords
tilt
shift
optical
iol
variable
Prior art date
Application number
PCT/NL2010/050270
Other languages
French (fr)
Inventor
Aleksey Nikolaevich Simonov
Michiel Christiaan Rombach
Original Assignee
Akkolens International B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akkolens International B.V. filed Critical Akkolens International B.V.
Publication of WO2010131955A1 publication Critical patent/WO2010131955A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1648—Multipart lenses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
    • A61F2/16—Intraocular lenses
    • A61F2/1613—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus
    • A61F2/1624—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside
    • A61F2/1632—Intraocular lenses having special lens configurations, e.g. multipart lenses; having particular optical properties, e.g. pseudo-accommodative lenses, lenses having aberration corrections, diffractive lenses, lenses for variably absorbing electromagnetic radiation, lenses having variable focus having adjustable focus; power activated variable focus means, e.g. mechanically or electrically by the ciliary muscle or from the outside for changing radial position, i.e. perpendicularly to the visual axis when implanted

Definitions

  • the invention is a specific intraocular lens (henceforth: " IOLs") with variable optical aberrations according to WO2008,071,760 which document is incorporated in full in the present document by reference.
  • the IOLs have two optical elements of which at least one is movable relative to the other in a direction perpendicular to the optical axis and wherein the elements have such a shape that their combination results in a lens providing at least one variable optical aberration of which the degree of variation depends on the degree of movement of the optical elements.
  • the IOL described in this document includes variable tilt, resulting in a shift of the image, of which the degree of tilt can be affected by the wearer by moving the optical elements with the natural accommodative apparatus of the eye.
  • tilt is the optical term referring to the direction of light and "shift” of the image referring to the position of the image on the retina; the IOL is referred to henceforth as “VS-IOL", Variable-Shift-IOL.
  • VS-IOL Variable-Shift-IOL.
  • any aberration, including tilt can be designed according to formulas and method described in WO2008, 071,760.
  • Such variable tilt is of benefit for treatment of Age- related Macula Degeneration (henceforth: "AMD”), which is an common ailment which afflicts the retina, including the macula and fovea (retina, macula and fovea referred to henceforth as "macula”).
  • AMD Age- related Macula Degeneration
  • AMD AMD affects a limited number of spots or sectors on the macula, especially at the onset of the ailment.
  • the wearer of the VS-IOL can affect tilt voluntarily by the natural accommodation apparatus of the eye, and thus shift the image to a healthy sector of the macula for improved vision.
  • Modern diagnostic equipment can now identify the healthy and blind sectors of the macula and the VS-IOL can be designed accordingly by, for example, adjusting the range of shift the initial angle of shift to maximize the effect.
  • the sulcus is the preferred position of the VS-IOL, a position described in detail in WO2009, 051,477 for accommodating IOLs of similar mechanical design.
  • the VS-IOL and the concept of variable tilt is novel. Note that an VS-IOL with a fixed tilt can be designed by limiting said range of tilt in, optionally, a combination with a preferred initial angle of permanent tilt.
  • a VS-IOL can include additional variable optical functions.
  • parabolic terms for tilt and shift of the image can be combined with, for example, cubic terms for a accommodative function.
  • the VS-IOL has, at least two, optical elements of which, at least one, is movable relative to the other in a direction perpendicular to the optical axis.
  • the optical elements are fitted in a construction (similar to the construction described in US2009,062,912) which allows for such movement and which is coupled to the natural accommodative apparatus of the eye.
  • At least one of the optical elements has, at least one, optical surface adapted to provide for a variable tilt, shift of the image, of which the degree of tilt depends on the degree of movement of the optical elements.
  • the application such IOLs is for accommodating IOLs of which the defocus aberration of the lens can be adjusted by the wearer with the natural accommodation apparatus of the eye as described in, for example, US2008,046,076 (basic optics), WO2009.051,477 (positioning in the eye) and US2009,062,912 and NL1028496 (construction and optics).
  • the VS-IOL is largely similar to these IOL designs except that the optical surfaces of the VS-IOL are adapted to pre-dominantly provide variable tilt which can be combined with other variable optical functions such as accommodation. .
  • the anterior surface of the anterior optical element, 1, has a limited optical function
  • the posterior surface of the anterior element, 2 has an optical surface for variable tilt, in this example a parabolic surface
  • the anterior surface of the posterior element, 3 has the complementary surface for variable tilt, in this example, a parabolic surface
  • the posterior of the posterior element, 4 has a spherical surface for correction of the refraction of the eye.
  • the range of movement of the optical elements is indicated by 5.
  • Figure 2 Graph showing the shift of the focal spot which depends on movement of the optical elements. Note that this is an example. The effects can differ based on the individual VS-IOL.
  • the lens has two optical surfaces to produce primarily a variable tilt of the transmitted light beam resulting in a shift of the image which effect can be combined with, optionally, other variable higher-order Zernike aberrations.
  • the shift of the image and Zernike aberrations depend linearly on the relative displacement of the optical surfaces. Assuming that the direction of displacement coincides with the X-axis, the sag function of the optical surface can be written as
  • OPD (n - I)Px Ax + (n - 1) ⁇ JC ⁇ C q Z q (x, y) + (n - ⁇ )R(x, y, Ax) , (2) q
  • the resulting OPD includes: 1. First term, (n - V)Px Ax , variable tilt which changes linearly with Ax ;

Abstract

A novel IOL includes variable tilt of which the degree can be affected by the wearer by moving the optical elements with the natural accommodative apparatus of the eye.The wearer of the VS-IOL can tilt the optical axis, and shift the image, to a healthy sector of the macula for improved vision. Modern diagnostic equipment can now identify the healthy and blind sectors of the macula and the VS-IOL can be designed accordingly by, for example, adjusting the range of shift the initial angle of shift.

Description

Intraocular lens with variable shift
The invention is a specific intraocular lens (henceforth: " IOLs") with variable optical aberrations according to WO2008,071,760 which document is incorporated in full in the present document by reference.
The IOLs have two optical elements of which at least one is movable relative to the other in a direction perpendicular to the optical axis and wherein the elements have such a shape that their combination results in a lens providing at least one variable optical aberration of which the degree of variation depends on the degree of movement of the optical elements. The IOL described in this document includes variable tilt, resulting in a shift of the image, of which the degree of tilt can be affected by the wearer by moving the optical elements with the natural accommodative apparatus of the eye. Note that "tilt" is the optical term referring to the direction of light and "shift" of the image referring to the position of the image on the retina; the IOL is referred to henceforth as "VS-IOL", Variable-Shift-IOL. The man skilled in the art will conclude that any aberration, including tilt, can be designed according to formulas and method described in WO2008, 071,760. Such variable tilt is of benefit for treatment of Age- related Macula Degeneration (henceforth: "AMD"), which is an common ailment which afflicts the retina, including the macula and fovea (retina, macula and fovea referred to henceforth as "macula"). Generally AMD affects a limited number of spots or sectors on the macula, especially at the onset of the ailment.
The wearer of the VS-IOL can affect tilt voluntarily by the natural accommodation apparatus of the eye, and thus shift the image to a healthy sector of the macula for improved vision. Modern diagnostic equipment can now identify the healthy and blind sectors of the macula and the VS-IOL can be designed accordingly by, for example, adjusting the range of shift the initial angle of shift to maximize the effect. The sulcus is the preferred position of the VS-IOL, a position described in detail in WO2009, 051,477 for accommodating IOLs of similar mechanical design. The VS-IOL and the concept of variable tilt is novel. Note that an VS-IOL with a fixed tilt can be designed by limiting said range of tilt in, optionally, a combination with a preferred initial angle of permanent tilt.
It should be noted that a VS-IOL can include additional variable optical functions. For example, parabolic terms for tilt and shift of the image can be combined with, for example, cubic terms for a accommodative function.
The VS-IOL has, at least two, optical elements of which, at least one, is movable relative to the other in a direction perpendicular to the optical axis. The optical elements are fitted in a construction (similar to the construction described in US2009,062,912) which allows for such movement and which is coupled to the natural accommodative apparatus of the eye. At least one of the optical elements has, at least one, optical surface adapted to provide for a variable tilt, shift of the image, of which the degree of tilt depends on the degree of movement of the optical elements.
The application such IOLs is for accommodating IOLs of which the defocus aberration of the lens can be adjusted by the wearer with the natural accommodation apparatus of the eye as described in, for example, US2008,046,076 (basic optics), WO2009.051,477 (positioning in the eye) and US2009,062,912 and NL1028496 (construction and optics). The VS-IOL is largely similar to these IOL designs except that the optical surfaces of the VS-IOL are adapted to pre-dominantly provide variable tilt which can be combined with other variable optical functions such as accommodation. .
Prior to manufacturing of the individual VS-IOL its specifications are defined, including, but not restricted to: - size of the VS-IOL construction (for proper mechanical functioning in the individual eye), - required fixed optical power (for proper correction of the refraction of the eye, a common procedure for all IOLs) - range of required tilt (based on the pattern of AMD of the individual eye; range expressed as, for example, degrees of shift of the image per unit of movement of the optical elements), - initial starting point of the variable shift (for example, a fixed tilt can direct the focal beam to a required starting position for the range). Such customization maximizes the improvement of vision. Figure 1. Cross section of the two-element intraocular lens for variable tilt. The anterior surface of the anterior optical element, 1, has a limited optical function, the posterior surface of the anterior element, 2, has an optical surface for variable tilt, in this example a parabolic surface, the anterior surface of the posterior element, 3, has the complementary surface for variable tilt, in this example, a parabolic surface, the posterior of the posterior element, 4, has a spherical surface for correction of the refraction of the eye. The range of movement of the optical elements is indicated by 5.
Figure 2. Graph showing the shift of the focal spot which depends on movement of the optical elements. Note that this is an example. The effects can differ based on the individual VS-IOL.
The lens has two optical surfaces to produce primarily a variable tilt of the transmitted light beam resulting in a shift of the image which effect can be combined with, optionally, other variable higher-order Zernike aberrations. The shift of the image and Zernike aberrations depend linearly on the relative displacement of the optical surfaces. Assuming that the direction of displacement coincides with the X-axis, the sag function of the optical surface can be written as
z = S(x,y) = ?-(x2 + y2)+ U∑CqZq (x,y)dx , (1)
4 2 q
where P is the tilt amplitude and Cq is the modal coefficient corresponding to the q-th
Zernike aberration term. If two optical elements with surfaces according to Eq. (1) are shifted by Ax (movement for each surface) in opposite directions, the resulting Optical Path Difference (OPD) becomes:
OPD = (n - I)Px Ax + (n - 1)ΔJC∑ CqZq (x, y) + (n - ϊ)R(x, y, Ax) , (2) q
With n the refractive index of the material. As follows from Eq. (2), the resulting OPD includes: 1. First term, (n - V)Px Ax , variable tilt which changes linearly with Ax ;
2. Second term, (n -ϊ)Ax∑CqZq(x, y) , all Zernike terms, Zq , including defocus. q
The amplitudes of these terms linearly vary with Ax .
3. The residual term, (n - V)R(x,y,Ax) , originates from higher-order shift- dependent contributions Δx3 , Δx5 , etc. When Δx « 1 , these contributions are negligibly small.

Claims

Claims
1. Intraocular lens comprising at least two optical elements, at least one of which is movable relative to the other in a direction perpendicular to the optical axis, which lens is coupled to the natural accommodative apparatus of the eye characterized in that at least one of the optical elements includes at least one optical surface adapted to provide for a variable tilt of which the degree of tilt depends on the degree of movement of the optical elements.
2. Intraocular lens according to claim 1 characterized in that the lens has at least one additional optical surface which is adapted to simultaneously provide for variable defocus.
3. Intraocular lens according to foregoing claims characterized in that the sag function of the optical surfaces is according to z = S(x,y) = ?-(x2 + y2)+ U∑CqZq (x,y)dx
PCT/NL2010/050270 2009-05-12 2010-05-11 Intraocular lens with variable shift WO2010131955A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL2002877 2009-05-12
NL2002877 2009-05-12

Publications (1)

Publication Number Publication Date
WO2010131955A1 true WO2010131955A1 (en) 2010-11-18

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Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2008105C2 (en) * 2012-01-11 2013-07-15 Procornea Holding Bv Intraocular lens.
DE102014106374A1 (en) 2013-05-07 2014-11-13 Akkolens International B.V. Accommodating intraocular lens with sulcus fixation haptics
WO2015159111A1 (en) 2014-04-18 2015-10-22 Medicontur Medical Engineering Ltd. Secondary intraocular lens with magnifying coaxial optical portion
US10159562B2 (en) 2014-09-22 2018-12-25 Kevin J. Cady Intraocular pseudophakic contact lenses and related systems and methods
WO2019022608A1 (en) * 2017-07-27 2019-01-31 Akkolens International B.V. Accommodating intraocular lens with free form optical surfaces
US10299910B2 (en) 2014-09-22 2019-05-28 Kevin J. Cady Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
WO2021034187A1 (en) 2019-08-19 2021-02-25 Akkolens International B.V. Accommodative intraocular lens combination with independent fixed and variable power lens sections
US10945832B2 (en) 2014-09-22 2021-03-16 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11109957B2 (en) 2014-09-22 2021-09-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11938018B2 (en) 2014-09-22 2024-03-26 Onpoint Vision, Inc. Intraocular pseudophakic contact lens (IOPCL) for treating age-related macular degeneration (AMD) or other eye disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007015640A1 (en) * 2005-05-13 2007-02-08 Akkolens International B.V. Improved intra-ocular artificial lens with variable optical strength
WO2008071760A2 (en) * 2006-12-13 2008-06-19 Akkolens International B.V. Accommodating intraocular lens with variable correction

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007015640A1 (en) * 2005-05-13 2007-02-08 Akkolens International B.V. Improved intra-ocular artificial lens with variable optical strength
WO2008071760A2 (en) * 2006-12-13 2008-06-19 Akkolens International B.V. Accommodating intraocular lens with variable correction

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL2008105C2 (en) * 2012-01-11 2013-07-15 Procornea Holding Bv Intraocular lens.
WO2013105855A1 (en) 2012-01-11 2013-07-18 Procornea Holding B.V. Intraocular lens
US10039635B2 (en) 2012-01-11 2018-08-07 Oculentis Holding B.V. Intraocular lens
DE102014106374A1 (en) 2013-05-07 2014-11-13 Akkolens International B.V. Accommodating intraocular lens with sulcus fixation haptics
US9861469B2 (en) 2013-05-07 2018-01-09 Akkolens International B.V. Accommodating intraocular lens with haptics for sulcus fixation
WO2015159111A1 (en) 2014-04-18 2015-10-22 Medicontur Medical Engineering Ltd. Secondary intraocular lens with magnifying coaxial optical portion
US10299910B2 (en) 2014-09-22 2019-05-28 Kevin J. Cady Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US10159562B2 (en) 2014-09-22 2018-12-25 Kevin J. Cady Intraocular pseudophakic contact lenses and related systems and methods
US10842614B2 (en) 2014-09-22 2020-11-24 Onpoint Vision, Inc. Intraocular pseudophakic contact lenses and related systems and methods
US10945832B2 (en) 2014-09-22 2021-03-16 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11109957B2 (en) 2014-09-22 2021-09-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11432921B2 (en) 2014-09-22 2022-09-06 Onpoint Vision, Inc. Intraocular pseudophakic contact lenses and related systems and methods
US11571293B2 (en) 2014-09-22 2023-02-07 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11583386B2 (en) 2014-09-22 2023-02-21 Onpoint Vision, Inc. Intraocular pseudophakic contact lens with mechanism for securing by anterior leaflet of capsular wall and related system and method
US11903818B2 (en) 2014-09-22 2024-02-20 Onpoint Vision, Inc. Intraocular pseudophakic contact lenses and related systems and methods
US11938018B2 (en) 2014-09-22 2024-03-26 Onpoint Vision, Inc. Intraocular pseudophakic contact lens (IOPCL) for treating age-related macular degeneration (AMD) or other eye disorders
WO2019022608A1 (en) * 2017-07-27 2019-01-31 Akkolens International B.V. Accommodating intraocular lens with free form optical surfaces
WO2021034187A1 (en) 2019-08-19 2021-02-25 Akkolens International B.V. Accommodative intraocular lens combination with independent fixed and variable power lens sections
DE112020003939T5 (en) 2019-08-19 2022-05-19 Akkolens International B.V. Accommodative intraocular lens combination with independent fixed and variable power lens parts

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