WO2010115612A3 - Pregabalin compositions - Google Patents

Pregabalin compositions

Info

Publication number
WO2010115612A3
WO2010115612A3 PCT/EP2010/002172 EP2010002172W WO2010115612A3 WO 2010115612 A3 WO2010115612 A3 WO 2010115612A3 EP 2010002172 W EP2010002172 W EP 2010002172W WO 2010115612 A3 WO2010115612 A3 WO 2010115612A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
pregabalin
comprises
lactose
composition
starch
Prior art date
Application number
PCT/EP2010/002172
Other languages
French (fr)
Other versions
WO2010115612A2 (en )
Inventor
FERNÁNDEZ Lisardo ÁLVAREZ
Original Assignee
Synthon B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4866Organic macromolecular compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid

Abstract

The invention relates to a solid pharmaceutical blend which comprises 100 parts of a pregabalin compound and at least 15 parts of a pregelatinized starch, wherein said blend is substantially free of lactose, and to a pharmaceutical capsule filling composition, which comprises a pregabalin compound, pregelatinized starch, and a lubricant; wherein said composition does not contain lactose, mannitol, or microcrystalline cellulose.
PCT/EP2010/002172 2009-04-10 2010-04-01 Pregabalin compositions WO2010115612A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US16836309 true 2009-04-10 2009-04-10
US61/168,363 2009-04-10

Publications (2)

Publication Number Publication Date
WO2010115612A2 true WO2010115612A2 (en) 2010-10-14
WO2010115612A3 true true WO2010115612A3 (en) 2011-02-03

Family

ID=42691170

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/002172 WO2010115612A3 (en) 2009-04-10 2010-04-01 Pregabalin compositions

Country Status (1)

Country Link
WO (1) WO2010115612A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102793685B (en) * 2012-08-14 2017-09-22 浙江华海药业股份有限公司 Oral capsule containing pregabalin and its preparation method
WO2015031228A1 (en) 2013-08-30 2015-03-05 Merck Sharp & Dohme Corp. Oral pharmaceutical formulation of omarigliptin

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001983A1 (en) * 1999-07-02 2001-01-11 Warner-Lambert Company A synergistic combination: gabapentin and pregabalin
WO2002078747A2 (en) * 2001-03-30 2002-10-10 Warner-Lambert Company Llc Pregabalin lactose conjugates
EP1591107A1 (en) * 2004-04-28 2005-11-02 Pfizer GmbH Arzneimittelwerk Gödecke Process for the selective increase of a release rate of an active material from a pharmaceutical composition
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2008128775A2 (en) * 2007-04-23 2008-10-30 Ratiopharm Gmbh Stabilised pharmaceutical composition containing pregabaline

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
US20080014280A1 (en) 2006-07-17 2008-01-17 Glenmark Pharmaceuticals Limited Amorphous pregabalin and process for the preparation thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001001983A1 (en) * 1999-07-02 2001-01-11 Warner-Lambert Company A synergistic combination: gabapentin and pregabalin
WO2002078747A2 (en) * 2001-03-30 2002-10-10 Warner-Lambert Company Llc Pregabalin lactose conjugates
EP1591107A1 (en) * 2004-04-28 2005-11-02 Pfizer GmbH Arzneimittelwerk Gödecke Process for the selective increase of a release rate of an active material from a pharmaceutical composition
WO2006121557A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
WO2008128775A2 (en) * 2007-04-23 2008-10-30 Ratiopharm Gmbh Stabilised pharmaceutical composition containing pregabaline

Also Published As

Publication number Publication date Type
WO2010115612A2 (en) 2010-10-14 application

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