WO2010113177A3 - Oral insulin delivery systems for controlling diabetes - Google Patents
Oral insulin delivery systems for controlling diabetes Download PDFInfo
- Publication number
- WO2010113177A3 WO2010113177A3 PCT/IN2010/000205 IN2010000205W WO2010113177A3 WO 2010113177 A3 WO2010113177 A3 WO 2010113177A3 IN 2010000205 W IN2010000205 W IN 2010000205W WO 2010113177 A3 WO2010113177 A3 WO 2010113177A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- insulin delivery
- delivery systems
- oral insulin
- controlling diabetes
- methods
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 229940125395 oral insulin Drugs 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 4
- 102000004877 Insulin Human genes 0.000 abstract 2
- 108090001061 Insulin Proteins 0.000 abstract 2
- 229940125396 insulin Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 239000004005 microsphere Substances 0.000 abstract 2
- 229920003134 Eudragit® polymer Polymers 0.000 abstract 1
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000000975 bioactive effect Effects 0.000 abstract 1
- 238000013270 controlled release Methods 0.000 abstract 1
- 239000003405 delayed action preparation Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 210000002784 stomach Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to orally delivered, controlled release preparation of insulin and other bioactive materials encapsulated in polymeric microspheres. pH-sensitive polymeric microspheres comprising Eudragit are provided. Methods for delivering drugs to the lower GI tract, while avoiding exposure to the stomach acids is provided. Methods for treating diabetes using controlled release insulin delivery particles are provided.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN856MU2009 | 2009-03-31 | ||
IN856/MUM/2009 | 2009-03-31 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2010113177A2 WO2010113177A2 (en) | 2010-10-07 |
WO2010113177A3 true WO2010113177A3 (en) | 2010-11-25 |
Family
ID=42753354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2010/000205 WO2010113177A2 (en) | 2009-03-31 | 2010-03-30 | Oral insulin delivery systems for controlling diabetes |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2010113177A2 (en) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9101547B2 (en) | 2011-08-04 | 2015-08-11 | Nano And Advanced Materials Institute Limited | Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery |
US8859004B2 (en) | 2011-08-04 | 2014-10-14 | Nano And Advanced Materials Institute Limited | pH-sensitive nanoparticles for oral insulin delivery |
CN102488619B (en) * | 2011-12-05 | 2014-08-06 | 上海交通大学 | Device for continuously producing exenatide microspheres and method for controlling release rate of microspheres |
GB201202433D0 (en) | 2012-02-13 | 2012-03-28 | Diurnal Ltd | Controlled drug release |
GB2510754B (en) * | 2013-02-12 | 2016-07-13 | Diurnal Ltd | Controlled drug release |
US11491114B2 (en) * | 2016-10-12 | 2022-11-08 | Curioralrx, Llc | Formulations for enteric delivery of therapeutic agents |
CN106667913A (en) * | 2017-02-13 | 2017-05-17 | 东华大学 | Preparation method of drug-loading pH (Potential of Hydrogen) sensitive self-assembling liposome |
CN110974943A (en) * | 2019-12-09 | 2020-04-10 | 广东药科大学 | Oral insulin pharmaceutical preparation and preparation method thereof |
CN111920956B (en) * | 2020-09-19 | 2022-04-08 | 北京英茂药业有限公司 | Targeted positioning type film coating premix and preparation method thereof |
CN115337403A (en) * | 2022-07-20 | 2022-11-15 | 广西中医药大学 | The use of chitosan grafted β-cyclodextrin polymer |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0800828A1 (en) * | 1994-12-28 | 1997-10-15 | Teikoku Hormone Mfg. Co., Ltd. | Transmucosal preparation |
US5731006A (en) * | 1991-04-19 | 1998-03-24 | Takeda Chemical Industries, Ltd. | Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition |
US20030220254A1 (en) * | 2002-03-29 | 2003-11-27 | Texas Tech University System | Composition and method for preparation of an oral dual controlled release formulation of a protein and inhibitor |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9323588D0 (en) | 1993-11-16 | 1994-01-05 | Cortecs Ltd | Hydrophobic preparation |
US5824638A (en) | 1995-05-22 | 1998-10-20 | Shire Laboratories, Inc. | Oral insulin delivery |
GB9605709D0 (en) | 1996-03-19 | 1996-05-22 | Cortecs Ltd | Method |
GB9613858D0 (en) | 1996-07-02 | 1996-09-04 | Cortecs Ltd | Hydrophobic preparations |
US6110434A (en) | 1998-02-25 | 2000-08-29 | Alumitech Of Cleveland, Inc. | Recovery of products from non-metallic products derived from aluminum dross |
CN1160122C (en) | 2001-04-20 | 2004-08-04 | 清华大学 | A kind of method for preparing oral insulin oil phase preparation |
-
2010
- 2010-03-30 WO PCT/IN2010/000205 patent/WO2010113177A2/en active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5731006A (en) * | 1991-04-19 | 1998-03-24 | Takeda Chemical Industries, Ltd. | Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition |
EP0800828A1 (en) * | 1994-12-28 | 1997-10-15 | Teikoku Hormone Mfg. Co., Ltd. | Transmucosal preparation |
US20030220254A1 (en) * | 2002-03-29 | 2003-11-27 | Texas Tech University System | Composition and method for preparation of an oral dual controlled release formulation of a protein and inhibitor |
Non-Patent Citations (4)
Title |
---|
DAMGE ET AL: "Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.JCONREL.2006.10.023, vol. 117, no. 2, 30 January 2007 (2007-01-30), pages 163 - 170, XP005864305, ISSN: 0168-3659 * |
KRAULAND A H ET AL: "Thiomers: development and in vitro evaluation of a peroral microparticulate peptide delivery system", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL LNKD- DOI:10.1016/J.EJPB.2003.09.011, vol. 57, no. 2, 1 March 2004 (2004-03-01), pages 181 - 187, XP004494293, ISSN: 0939-6411 * |
MORISHITA I ET AL: "Enteral insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL LNKD- DOI:10.1016/0378-5173(93)90418-F, vol. 91, no. 1, 5 April 1993 (1993-04-05), pages 29 - 37, XP023845207, ISSN: 0378-5173, [retrieved on 19930405] * |
MORISHITA I ET AL: "Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL LNKD- DOI:10.1016/0378-5173(92)90349-7, vol. 78, no. 1-3, 1 January 1992 (1992-01-01), pages 9 - 16, XP023856472, ISSN: 0378-5173, [retrieved on 19920101] * |
Also Published As
Publication number | Publication date |
---|---|
WO2010113177A2 (en) | 2010-10-07 |
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