WO2010113177A3 - Oral insulin delivery systems for controlling diabetes - Google Patents

Oral insulin delivery systems for controlling diabetes Download PDF

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Publication number
WO2010113177A3
WO2010113177A3 PCT/IN2010/000205 IN2010000205W WO2010113177A3 WO 2010113177 A3 WO2010113177 A3 WO 2010113177A3 IN 2010000205 W IN2010000205 W IN 2010000205W WO 2010113177 A3 WO2010113177 A3 WO 2010113177A3
Authority
WO
WIPO (PCT)
Prior art keywords
insulin delivery
delivery systems
oral insulin
controlling diabetes
methods
Prior art date
Application number
PCT/IN2010/000205
Other languages
French (fr)
Other versions
WO2010113177A2 (en
Inventor
Rangaswamy Vidhya
Malleshappa Aminabhavi Tejraj
Ramesh Babu Vadde
Chaluvayya Mundargi Raghavendra
Hiremath Anand
Original Assignee
Reliance Life Sciences Pvt. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reliance Life Sciences Pvt. Ltd. filed Critical Reliance Life Sciences Pvt. Ltd.
Publication of WO2010113177A2 publication Critical patent/WO2010113177A2/en
Publication of WO2010113177A3 publication Critical patent/WO2010113177A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

The present invention relates to orally delivered, controlled release preparation of insulin and other bioactive materials encapsulated in polymeric microspheres. pH-sensitive polymeric microspheres comprising Eudragit are provided. Methods for delivering drugs to the lower GI tract, while avoiding exposure to the stomach acids is provided. Methods for treating diabetes using controlled release insulin delivery particles are provided.
PCT/IN2010/000205 2009-03-31 2010-03-30 Oral insulin delivery systems for controlling diabetes WO2010113177A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN856MU2009 2009-03-31
IN856/MUM/2009 2009-03-31

Publications (2)

Publication Number Publication Date
WO2010113177A2 WO2010113177A2 (en) 2010-10-07
WO2010113177A3 true WO2010113177A3 (en) 2010-11-25

Family

ID=42753354

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2010/000205 WO2010113177A2 (en) 2009-03-31 2010-03-30 Oral insulin delivery systems for controlling diabetes

Country Status (1)

Country Link
WO (1) WO2010113177A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9101547B2 (en) 2011-08-04 2015-08-11 Nano And Advanced Materials Institute Limited Enteric-coated capsule containing cationic nanoparticles for oral insulin delivery
US8859004B2 (en) 2011-08-04 2014-10-14 Nano And Advanced Materials Institute Limited pH-sensitive nanoparticles for oral insulin delivery
CN102488619B (en) * 2011-12-05 2014-08-06 上海交通大学 Device for continuously producing exenatide microspheres and method for controlling release rate of microspheres
GB201202433D0 (en) 2012-02-13 2012-03-28 Diurnal Ltd Controlled drug release
GB2510754B (en) * 2013-02-12 2016-07-13 Diurnal Ltd Controlled drug release
US11491114B2 (en) * 2016-10-12 2022-11-08 Curioralrx, Llc Formulations for enteric delivery of therapeutic agents
CN106667913A (en) * 2017-02-13 2017-05-17 东华大学 Preparation method of drug-loading pH (Potential of Hydrogen) sensitive self-assembling liposome
CN110974943A (en) * 2019-12-09 2020-04-10 广东药科大学 Oral insulin pharmaceutical preparation and preparation method thereof
CN111920956B (en) * 2020-09-19 2022-04-08 北京英茂药业有限公司 Targeted positioning type film coating premix and preparation method thereof
CN115337403A (en) * 2022-07-20 2022-11-15 广西中医药大学 The use of chitosan grafted β-cyclodextrin polymer

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0800828A1 (en) * 1994-12-28 1997-10-15 Teikoku Hormone Mfg. Co., Ltd. Transmucosal preparation
US5731006A (en) * 1991-04-19 1998-03-24 Takeda Chemical Industries, Ltd. Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition
US20030220254A1 (en) * 2002-03-29 2003-11-27 Texas Tech University System Composition and method for preparation of an oral dual controlled release formulation of a protein and inhibitor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9323588D0 (en) 1993-11-16 1994-01-05 Cortecs Ltd Hydrophobic preparation
US5824638A (en) 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
GB9605709D0 (en) 1996-03-19 1996-05-22 Cortecs Ltd Method
GB9613858D0 (en) 1996-07-02 1996-09-04 Cortecs Ltd Hydrophobic preparations
US6110434A (en) 1998-02-25 2000-08-29 Alumitech Of Cleveland, Inc. Recovery of products from non-metallic products derived from aluminum dross
CN1160122C (en) 2001-04-20 2004-08-04 清华大学 A kind of method for preparing oral insulin oil phase preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5731006A (en) * 1991-04-19 1998-03-24 Takeda Chemical Industries, Ltd. Gastrointestinal mucosa-adherent granules, pharmaceutical preparations and a coating composition
EP0800828A1 (en) * 1994-12-28 1997-10-15 Teikoku Hormone Mfg. Co., Ltd. Transmucosal preparation
US20030220254A1 (en) * 2002-03-29 2003-11-27 Texas Tech University System Composition and method for preparation of an oral dual controlled release formulation of a protein and inhibitor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DAMGE ET AL: "Oral delivery of insulin associated to polymeric nanoparticles in diabetic rats", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL LNKD- DOI:10.1016/J.JCONREL.2006.10.023, vol. 117, no. 2, 30 January 2007 (2007-01-30), pages 163 - 170, XP005864305, ISSN: 0168-3659 *
KRAULAND A H ET AL: "Thiomers: development and in vitro evaluation of a peroral microparticulate peptide delivery system", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL LNKD- DOI:10.1016/J.EJPB.2003.09.011, vol. 57, no. 2, 1 March 2004 (2004-03-01), pages 181 - 187, XP004494293, ISSN: 0939-6411 *
MORISHITA I ET AL: "Enteral insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL LNKD- DOI:10.1016/0378-5173(93)90418-F, vol. 91, no. 1, 5 April 1993 (1993-04-05), pages 29 - 37, XP023845207, ISSN: 0378-5173, [retrieved on 19930405] *
MORISHITA I ET AL: "Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats", INTERNATIONAL JOURNAL OF PHARMACEUTICS, ELSEVIER BV, NL LNKD- DOI:10.1016/0378-5173(92)90349-7, vol. 78, no. 1-3, 1 January 1992 (1992-01-01), pages 9 - 16, XP023856472, ISSN: 0378-5173, [retrieved on 19920101] *

Also Published As

Publication number Publication date
WO2010113177A2 (en) 2010-10-07

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