WO2010091877A3 - Procédé de production d'ambrisentan - Google Patents

Procédé de production d'ambrisentan Download PDF

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Publication number
WO2010091877A3
WO2010091877A3 PCT/EP2010/000885 EP2010000885W WO2010091877A3 WO 2010091877 A3 WO2010091877 A3 WO 2010091877A3 EP 2010000885 W EP2010000885 W EP 2010000885W WO 2010091877 A3 WO2010091877 A3 WO 2010091877A3
Authority
WO
WIPO (PCT)
Prior art keywords
ambrisentan
producing
relates
reflections
methoxy
Prior art date
Application number
PCT/EP2010/000885
Other languages
English (en)
Other versions
WO2010091877A2 (fr
Inventor
Ramesh Matioram Gidwani
Christian Janssen
Alexandre Mathieu
Wolfgang Albrecht
Frank Lehmamnn
Original Assignee
Ratiopharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE200920009917 external-priority patent/DE202009009917U1/de
Application filed by Ratiopharm Gmbh filed Critical Ratiopharm Gmbh
Publication of WO2010091877A2 publication Critical patent/WO2010091877A2/fr
Publication of WO2010091877A3 publication Critical patent/WO2010091877A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

L'invention porte sur un procédé de production d'ambrisentan (I) consistant à faire réagir de l'acide (S)-2-hydroxy-3-méthoxy-3,3-diphénylpropanoïque (II) avec un dérivé de 4,6-diméthyl-pyrimidine (III). L'invention porte également sur de ambrisentan sous forme cristalline, caractérisé en ce que le schéma de diffraction de la poudre sous rayons X présente des réflexions d'environ 8,9°, 12,3°, 17,9° et 26,9°, à l'échelle 2-thêta.
PCT/EP2010/000885 2009-02-13 2010-02-12 Procédé de production d'ambrisentan WO2010091877A2 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IN291/DEL/2009 2009-02-13
IN291DE2009 2009-02-13
DE202009009917.2 2009-07-21
DE200920009917 DE202009009917U1 (de) 2009-07-21 2009-07-21 Ambrisentan in spezifischer kristalliner Form

Publications (2)

Publication Number Publication Date
WO2010091877A2 WO2010091877A2 (fr) 2010-08-19
WO2010091877A3 true WO2010091877A3 (fr) 2010-11-11

Family

ID=42060719

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/000885 WO2010091877A2 (fr) 2009-02-13 2010-02-12 Procédé de production d'ambrisentan

Country Status (1)

Country Link
WO (1) WO2010091877A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2462065T3 (es) 2009-07-10 2014-05-22 Cadila Healthcare Limited Proceso mejorado para la preparación de Ambrisentán e intermedios novedosos de este
EP2476670A1 (fr) 2011-01-07 2012-07-18 Zentiva, K.S. Seuls solides stabiles de l'ambrisentane
CN102276536B (zh) * 2011-06-10 2015-04-29 中国科学院化学研究所 一种光学纯的(+)-安倍生坦和光学纯的(+)-达芦生坦的制备方法
CN102887861B (zh) * 2011-07-18 2015-04-15 天津市医药集团技术发展有限公司 一种安贝生坦新晶型及其制备方法
AU2012324612A1 (en) 2011-10-19 2014-05-15 Cipla Limited Process for the preparation of an endothelin receptor antagonist
CN102627613A (zh) * 2012-02-27 2012-08-08 中国药科大学 一种2-[(4,6-二甲基嘧啶-2-)氧基]-3-腈基-3,3-二苯基丙酸光学异构体及其制备、方法医药用途
CN103524424A (zh) * 2012-07-04 2014-01-22 天津药物研究院 一种安立生坦的晶型vi及其制备方法和应用
CN103524425A (zh) * 2012-07-04 2014-01-22 天津药物研究院 一种安立生坦的晶型v及其制备方法和应用
CN104280480B (zh) * 2013-07-02 2016-12-28 天津药物研究院有限公司 一种分离检测安立生坦及其有关物质的方法
CN103396370B (zh) * 2013-07-26 2018-11-16 浙江华海药业股份有限公司 一种安立生坦的纯化方法
CN103709106A (zh) * 2013-12-06 2014-04-09 石家庄博策生物科技有限公司 一种立体选择性制备安立生坦的方法
CN103739557B (zh) * 2013-12-30 2015-10-21 黄河三角洲京博化工研究院有限公司 一种4,6-二甲基-2-甲磺酰基嘧啶的合成方法
CN104177300B (zh) * 2014-03-18 2016-02-24 上海美悦生物科技发展有限公司 一种安立生坦降解产物及其制备方法
CN106093250A (zh) * 2016-08-27 2016-11-09 江苏嘉逸医药有限公司 一种高效液相色谱法测定安立生坦含量的方法
CN109705042B (zh) * 2017-10-26 2021-12-21 正大天晴药业集团股份有限公司 一种安立生坦的制备方法
CN110437063B (zh) * 2018-05-03 2022-04-29 常州恒邦药业有限公司 安立生坦关键中间体的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011914A1 (fr) * 1994-10-14 1996-04-25 Basf Aktiengesellschaft Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19850301A1 (de) 1998-10-30 2000-05-04 Basf Ag Verfahren zur Racematspaltung von 2-Hydroxypropionsäuren

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996011914A1 (fr) * 1994-10-14 1996-04-25 Basf Aktiengesellschaft Nouveaux derives d'acide carboxylique, leur preparation et leur utilisation

Also Published As

Publication number Publication date
WO2010091877A2 (fr) 2010-08-19

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