WO2010076334A3 - Intraoperative diagnosis of primary tumors and secondary tumors or metastases - Google Patents

Intraoperative diagnosis of primary tumors and secondary tumors or metastases Download PDF

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Publication number
WO2010076334A3
WO2010076334A3 PCT/EP2009/068060 EP2009068060W WO2010076334A3 WO 2010076334 A3 WO2010076334 A3 WO 2010076334A3 EP 2009068060 W EP2009068060 W EP 2009068060W WO 2010076334 A3 WO2010076334 A3 WO 2010076334A3
Authority
WO
WIPO (PCT)
Prior art keywords
tumors
metastases
primary
intraoperative diagnosis
primary tumors
Prior art date
Application number
PCT/EP2009/068060
Other languages
French (fr)
Other versions
WO2010076334A2 (en
Inventor
Aurélie DUTOUR
Raphaël ROUSSEAU
Original Assignee
Centre Leon Berard
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Leon Berard filed Critical Centre Leon Berard
Publication of WO2010076334A2 publication Critical patent/WO2010076334A2/en
Publication of WO2010076334A3 publication Critical patent/WO2010076334A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to the improvement of the detection of the surgical margins of primary tumors as well as to the improvement of the resection of secondary tumors (metastases), most notably pulmonary metastases. The invention notably relates to the use of a RAFT scaffold on which have been grafted both a marker detectable in the near infrared and a ligand of the αvβ3 integrins.
PCT/EP2009/068060 2008-12-31 2009-12-31 Intraoperative diagnosis of primary tumors and secondary tumors or metastases WO2010076334A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14171208P 2008-12-31 2008-12-31
US61/141,712 2008-12-31

Publications (2)

Publication Number Publication Date
WO2010076334A2 WO2010076334A2 (en) 2010-07-08
WO2010076334A3 true WO2010076334A3 (en) 2010-09-23

Family

ID=42245618

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/068060 WO2010076334A2 (en) 2008-12-31 2009-12-31 Intraoperative diagnosis of primary tumors and secondary tumors or metastases

Country Status (1)

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WO (1) WO2010076334A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20050328A1 (en) 2005-03-03 2006-09-04 Univ Degli Studi Milano PEPTIDOMIMETRIC COMPOUNDS AND PREPARATION OF BIOLOGICALLY ACTIVE DERIVATIVES
WO2013162502A1 (en) * 2012-04-23 2013-10-31 Empire Technology Development Llc Tissue visualization for resection
JP6793122B2 (en) 2014-12-19 2020-12-02 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． Intraoperative imaging

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026894A2 (en) * 2002-09-19 2004-04-01 Centre National De La Recherche Scientifique - Cnrs Synthesis and characterization of novel systems for guidance and vectorization of compounds having a therapeutic activity
WO2005019247A2 (en) * 2003-08-15 2005-03-03 Board Of Regents, The University Of Texas System Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy
WO2005058370A1 (en) * 2003-12-18 2005-06-30 Amersham Health As Optical imaging contrast agents for imaging lung cancer
WO2005058372A1 (en) * 2003-12-18 2005-06-30 Amersham Health As Optical imaging contrast agents for imaging lung cancer
WO2007010128A1 (en) * 2005-07-21 2007-01-25 Commissariat A L'energie Atomique Target vector with activable imaging function
WO2007070784A2 (en) * 2005-12-12 2007-06-21 The Uab Research Foundation Fluorescent detection of cancer and fluorescent guided surgical removal
WO2007136413A2 (en) * 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
WO2009114776A2 (en) * 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026894A2 (en) * 2002-09-19 2004-04-01 Centre National De La Recherche Scientifique - Cnrs Synthesis and characterization of novel systems for guidance and vectorization of compounds having a therapeutic activity
WO2005019247A2 (en) * 2003-08-15 2005-03-03 Board Of Regents, The University Of Texas System Cyclic peptide and imaging compound compositions and uses for targeted imaging and therapy
WO2005058370A1 (en) * 2003-12-18 2005-06-30 Amersham Health As Optical imaging contrast agents for imaging lung cancer
WO2005058372A1 (en) * 2003-12-18 2005-06-30 Amersham Health As Optical imaging contrast agents for imaging lung cancer
WO2007010128A1 (en) * 2005-07-21 2007-01-25 Commissariat A L'energie Atomique Target vector with activable imaging function
WO2007070784A2 (en) * 2005-12-12 2007-06-21 The Uab Research Foundation Fluorescent detection of cancer and fluorescent guided surgical removal
WO2007136413A2 (en) * 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
WO2009114776A2 (en) * 2008-03-14 2009-09-17 Visen Medical, Inc. Integrin targeting agents and methods of using same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GARANGER ET AL: "New Multifunctional Molecular Conjugate Vector for Targeting, Imaging, and Therapy of Tumors", MOLECULAR THERAPY, ACADEMIC PRESS, SAN DIEGO, CA, US LNKD- DOI:10.1016/J.YMTHE.2005.06.095, vol. 12, no. 6, 1 December 2005 (2005-12-01), pages 1168 - 1175, XP005176625, ISSN: 1525-0016 *
JIN ZHAO-HUI ET AL: "In vivo optical imaging of integrin [alpha]V-[beta]3 in mice using multivalent or monovalent cRGD targeting vectors", MOLECULAR CANCER, BIOMED CENTRAL, LONDON, GB LNKD- DOI:10.1186/1476-4598-6-41, vol. 6, no. 1, 12 June 2007 (2007-06-12), pages 41, XP021029907, ISSN: 1476-4598 *

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Publication number Publication date
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