WO2010052584A2 - Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh - Google Patents

Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh Download PDF

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Publication number
WO2010052584A2
WO2010052584A2 PCT/IB2009/007662 IB2009007662W WO2010052584A2 WO 2010052584 A2 WO2010052584 A2 WO 2010052584A2 IB 2009007662 W IB2009007662 W IB 2009007662W WO 2010052584 A2 WO2010052584 A2 WO 2010052584A2
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WO
WIPO (PCT)
Prior art keywords
bacterial cellulose
medical device
cellulose sheet
perforations
size
Prior art date
Application number
PCT/IB2009/007662
Other languages
French (fr)
Other versions
WO2010052584A3 (en
Inventor
Yves Bayon
Sébastien LADET
Olivier Lefranc
Philippe Gravagna
Original Assignee
Sofradim Production
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sofradim Production filed Critical Sofradim Production
Priority to AU2009312479A priority Critical patent/AU2009312479A1/en
Priority to CA2741518A priority patent/CA2741518A1/en
Priority to US13/125,604 priority patent/US20110262696A1/en
Priority to EP09801999A priority patent/EP2349075A2/en
Publication of WO2010052584A2 publication Critical patent/WO2010052584A2/en
Publication of WO2010052584A3 publication Critical patent/WO2010052584A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0004—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse
    • A61F2/0031—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra
    • A61F2/0036—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse for constricting the lumen; Support slings for the urethra implantable
    • A61F2/0045—Support slings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0077—Special surfaces of prostheses, e.g. for improving ingrowth
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/24—Structurally defined web or sheet [e.g., overall dimension, etc.]
    • Y10T428/24273—Structurally defined web or sheet [e.g., overall dimension, etc.] including aperture

Definitions

  • the present disclosure relates to medical devices including a perforated bacterial cellulose sheet.
  • the disclosure also relates to the use of the medical device for indications where soft tissues need to be repaired, reinforced or replaced such as, for example, the abdominal wall or pelvic floor.
  • An aspect of the present invention is a medical device comprising a bacterial cellulose sheet having perforations.
  • the bacterial cellulose sheet may have a thickness of from about 0.1 mm to about 5 mm.
  • the perforations comprise holes of a size from about 10 ⁇ m and 100 ⁇ m, separated from each other by a distance of from about 0.1 mm to about 3 mm. In embodiments, the perforations comprise holes of a size of from about 1 mm to about 3 mm, separated from each other by a distance of from about 0.3 mm to about 5 mm. In embodiments, the perforations comprise holes of a size of from about 10 ⁇ m to about 100 ⁇ m, separated from each other by a distance of from about 100 ⁇ m to about 500 ⁇ m. In embodiments, the holes are arranged in an ordered series. In embodiments, the bacterial cellulose sheet comprises a first area having perforations and a second area containing no perforations.
  • the bacterial cellulose sheet comprises a first area having perforations of a first size and a second area having perforations of a second size different from the first size. In embodiments, the bacterial cellulose sheet comprises a first area with perforations arranged in a first pattern and a second area with perforations arranged in a second pattern different from the first pattern. The perforations may be circular.
  • Another aspect of the invention is a method of making a medical device comprising: providing a bacterial cellulose sheet; and perforating the bacterial cellulose sheet.
  • the bacterial cellulose sheet provided may be derived from Acetobacter xylinum.
  • the bacterial cellulose sheet provided comprises oxidized cellulose.
  • perforating the bacterial cellulose sheet forms holes of a size of from about 10 ⁇ m and 100 ⁇ m, separated from each other by a distance of from about 0.1 mm to about 3 mm.
  • perforating the bacterial cellulose sheet forms holes of a size of from about 1 mm to about 3 mm, separated from each other by a distance of from about 0.3 mm to about 5 mm.
  • perforating the bacterial cellulose sheet forms holes of a defined and constant size of from about 10 ⁇ m to about 100 ⁇ m, separated from each other by a constant distance of from about 100 ⁇ m to about 500 ⁇ m. In embodiments, perforating the bacterial cellulose sheet forms an ordered series of holes. In embodiments, an area of the bacterial cellulose sheet remains unperforated. Perforating may be performed by a method selected from the group consisting of punching and laser drilling.
  • the microbial cellulose as wet pellicles or films may be produced from bacteria that synthesize cellulose.
  • Cellulose is synthesized by bacteria belonging to the genera Acetobacter, Rhizobium, Agrobacterium, and Sarcina.
  • Cellulose may be produced by certain bacteria from glucose in the presence of oxygen, (such as, for example, Acetobacter xylinum, referenced hereinafter as the "bacteria"), in static conditions or in a bioreactor (see, e.g. U.S. Patent Nos.
  • Cellulose suitable for use in the present implants may be obtained by the fermentation of the bacteria.
  • a derivative of the cellulose is employed, such as oxidized cellulose resulting from the oxidation of the cellulose by periodic acid or nitrogen dioxide.
  • Microbial cellulose possesses inherent characteristics which allow effective promotion of wound healing (see, e.g. U.S. Patent No. 7,390,492, the entire disclosure of which is incorporated herein by this reference).
  • microbial cellulose displays properties that distinguish it from plant cellulose and other natural polymeric materials, such as a unique multi-layer three dimensional laminar structures.
  • Microbial cellulose shows excellent wet strength, does not easily breakdown under compression and demonstrates high moisture handling ability. When implanted in vivo, bacterial cellulose pellicles or films are rather slowly integrated in tissues and cell colonized.
  • Methods for producing cellulose pellicles or films in accordance with the present disclosure involve culturing cellulose-producing bacteria in culture vessels or bioreactors to produce microbial pellicles or films which are microperforated or perforated. (See Figs. 1 and 2) Perforation of the film increases the rate of tissue integration of the present cellulose devices compared to non-perforated films. The present devices are therefore useful wherever a healing support is needed for the reinforcement, repair or replacement of soft tissues.
  • the devices resulting from the growth of the bacterial cellulose sheets according to the present disclosure can have a final thickness of from about 0.1 mm to about 5 mm, in embodiments, of from about 0.3 mm to about 1.5 mm.
  • the perforations can be an ordered series of holes of a defined and constant size of from about 10 ⁇ m and 100 ⁇ m, separated from each other by a constant distance of from about 0.1 mm to about 3 mm, in embodiments, from about 0.5 mm to about 1 mm.
  • Such devices are hereafter referenced as microperforated cellulose sheets.
  • these and further devices may be attained by the bacterial cellulose sheets according to the present disclosure, having a final thickness of from about 0.1 mm to about 5 mm, in embodiments, of from about 0.5 mm to about 3 mm, and having an ordered series of holes of a defined and constant size of from about 1 mm to about 3 mm, separated from each other by a constant distance of from about 0.3 mm to about 5 mm, in embodiments, of from about 0.5 mm to about 2 mm.
  • Such devices are hereafter referenced as perforated cellulose sheets.
  • the devices described herein include two or more areas having different sets of perforations. (See Fig.
  • a first area may have a first set of perforations having a first set of characteristics and a second area may have a second set of perforations having a second set of characteristics.
  • a sheet having a first area perforated in one area as described in the previous paragraph may be perforated in another area to provide holes of a defined and constant size of from about 10 ⁇ m to about 100 ⁇ m, separated from each other by a constant distance of from about 100 ⁇ m to about 500 ⁇ m, in embodiments, of from about 100 ⁇ m to about 200 ⁇ m.
  • the holes in the devices may not be simply ordered, but may be arranged according to more complex sequences. For example, the distance between holes may vary across the surface of the device.
  • the sheet may include rows of closely spaced holes separated by some distance.
  • a series of five rows of 100 ⁇ m diameter holes may be separated by each other at a distance of from about 200 ⁇ m to about 400 ⁇ m and this series of holes may be separated from another series of similarly sized and spaced rows by distance of from about 1 mm to about 5 mm.
  • the holes of the perforated and microperforated cellulose sheets may have any shape or geometry.
  • the holes may be a circle, a square, a rectangle, an oval, or an ellipse. It should be understood that the use of other shapes or combinations of shapes are also contemplated.
  • Continuous perforated or microperforated bacterial cellulose sheets may be prepared by any conventional methods known in the art.
  • the perforated and microperforated cellulose sheets according to the present disclosure may be obtained using mechanical perforation devices such as suitably arranged punching machines. Alternatively, thermal or ultraviolet lasers operating in a frequency band such as to produce holes of the required size and distance apart in the cellulose sheet may be used.
  • the perforated and microperforated cellulose sheets according to the present disclosure may also be obtained by other suitable processes, such as vacuum, needle or water jet perforation, hot pins, embossing, and combinations thereof.
  • perforation of the cellulose sheets may be performed on wet or dry materials. [0018] In embodiments, perforation of the cellulose sheets may be performed at the end of the fermentation process when the cellulose pellicles or films are harvested. In embodiments, perforation may be performed when the medical device is at the final processing stage. At this stage, the cellulose sheets may be perforated or microperforated, then cut to shape and sizes appropriate for the envisaged application.
  • the cellulose sheets may be packaged in single or dual pouches and sterilized using conventional techniques, such as, but not limited to, irradiation with beta (electronic irradiation) or gamma (irradiation using radioactive cobalt) rays at about 25 KGy to about 35 KGy 1 and/or sterilized by ethylene oxide.
  • conventional techniques such as, but not limited to, irradiation with beta (electronic irradiation) or gamma (irradiation using radioactive cobalt) rays at about 25 KGy to about 35 KGy 1 and/or sterilized by ethylene oxide.
  • the cellulose sheets are packaged under sufficiently dry conditions to ensure that no degradation of the composite takes place during storage.
  • the present medical devices including bacterial cellulose sheets which are microperforated or perforated may advantageously maintain one or more of the unique properties of bacterial cellulose sheets.
  • the present sheets may exhibit high biocompatibility, extreme hydrophilicity, a multi-layered three dimensional laminar structures providing excellent moisture handling properties, excellent wet strength, high resistance to breakdown under compression, conformability and the absence of generation of harmful particles of the cellulose mesh after rubbing against surrounding tissues or erosion at sharp edges of tissues (e.g., sharp edges of bone and cartilage tissues).
  • the perforated bacterial cellulose sheets of the present disclosure may be used for the repair, reinforcing and/or replacement of soft tissues, such as for example, the abdominal wall and pelvic floor.

Abstract

The present invention relates to a medical device comprising a bacterial cellulose sheet having perforations. The invention further relates to a method of making such a medical device.

Description

MEDICAL DEVICE INCLUDING A BACTERIAL CELLULOSE SHEET, PERFORATED OR MICROPERFORATED AS A MESH [0001] The present disclosure relates to medical devices including a perforated bacterial cellulose sheet. The disclosure also relates to the use of the medical device for indications where soft tissues need to be repaired, reinforced or replaced such as, for example, the abdominal wall or pelvic floor. [0002] An aspect of the present invention is a medical device comprising a bacterial cellulose sheet having perforations. The bacterial cellulose sheet may have a thickness of from about 0.1 mm to about 5 mm. In embodiments, the perforations comprise holes of a size from about 10 μm and 100 μm, separated from each other by a distance of from about 0.1 mm to about 3 mm. In embodiments, the perforations comprise holes of a size of from about 1 mm to about 3 mm, separated from each other by a distance of from about 0.3 mm to about 5 mm. In embodiments, the perforations comprise holes of a size of from about 10 μm to about 100 μm, separated from each other by a distance of from about 100 μm to about 500 μm. In embodiments, the holes are arranged in an ordered series. In embodiments, the bacterial cellulose sheet comprises a first area having perforations and a second area containing no perforations. In embodiments, the bacterial cellulose sheet comprises a first area having perforations of a first size and a second area having perforations of a second size different from the first size. In embodiments, the bacterial cellulose sheet comprises a first area with perforations arranged in a first pattern and a second area with perforations arranged in a second pattern different from the first pattern. The perforations may be circular.
[0003] Another aspect of the invention is a method of making a medical device comprising: providing a bacterial cellulose sheet; and perforating the bacterial cellulose sheet.
[0004] The bacterial cellulose sheet provided may be derived from Acetobacter xylinum. In embodiments, the bacterial cellulose sheet provided comprises oxidized cellulose. In embodiments, perforating the bacterial cellulose sheet forms holes of a size of from about 10 μm and 100 μm, separated from each other by a distance of from about 0.1 mm to about 3 mm. In embodiments, perforating the bacterial cellulose sheet forms holes of a size of from about 1 mm to about 3 mm, separated from each other by a distance of from about 0.3 mm to about 5 mm. In embodiments, perforating the bacterial cellulose sheet forms holes of a defined and constant size of from about 10 μm to about 100 μm, separated from each other by a constant distance of from about 100 μm to about 500 μm. In embodiments, perforating the bacterial cellulose sheet forms an ordered series of holes. In embodiments, an area of the bacterial cellulose sheet remains unperforated. Perforating may be performed by a method selected from the group consisting of punching and laser drilling.
[0005] Another aspect of the present invention is a method of repairing a wound comprising contacting a wound with a medical device as described above. [0006] In the present disclosure, the microbial cellulose as wet pellicles or films may be produced from bacteria that synthesize cellulose. Cellulose is synthesized by bacteria belonging to the genera Acetobacter, Rhizobium, Agrobacterium, and Sarcina. Cellulose may be produced by certain bacteria from glucose in the presence of oxygen, (such as, for example, Acetobacter xylinum, referenced hereinafter as the "bacteria"), in static conditions or in a bioreactor (see, e.g. U.S. Patent Nos. 4,912,049 and 5,955,326, the entire disclosures of which are incorporated herein by this reference). Cellulose suitable for use in the present implants may be obtained by the fermentation of the bacteria. In embodiments, a derivative of the cellulose is employed, such as oxidized cellulose resulting from the oxidation of the cellulose by periodic acid or nitrogen dioxide.
[0007] Microbial cellulose possesses inherent characteristics which allow effective promotion of wound healing (see, e.g. U.S. Patent No. 7,390,492, the entire disclosure of which is incorporated herein by this reference). In this regard, microbial cellulose displays properties that distinguish it from plant cellulose and other natural polymeric materials, such as a unique multi-layer three dimensional laminar structures. Microbial cellulose shows excellent wet strength, does not easily breakdown under compression and demonstrates high moisture handling ability. When implanted in vivo, bacterial cellulose pellicles or films are rather slowly integrated in tissues and cell colonized. [0008] Methods for producing cellulose pellicles or films in accordance with the present disclosure involve culturing cellulose-producing bacteria in culture vessels or bioreactors to produce microbial pellicles or films which are microperforated or perforated. (See Figs. 1 and 2) Perforation of the film increases the rate of tissue integration of the present cellulose devices compared to non-perforated films. The present devices are therefore useful wherever a healing support is needed for the reinforcement, repair or replacement of soft tissues.
[0009] In embodiments, the devices resulting from the growth of the bacterial cellulose sheets according to the present disclosure, can have a final thickness of from about 0.1 mm to about 5 mm, in embodiments, of from about 0.3 mm to about 1.5 mm. In embodiments, the perforations can be an ordered series of holes of a defined and constant size of from about 10 μm and 100 μm, separated from each other by a constant distance of from about 0.1 mm to about 3 mm, in embodiments, from about 0.5 mm to about 1 mm. Such devices are hereafter referenced as microperforated cellulose sheets. [0010] In embodiments, these and further devices may be attained by the bacterial cellulose sheets according to the present disclosure, having a final thickness of from about 0.1 mm to about 5 mm, in embodiments, of from about 0.5 mm to about 3 mm, and having an ordered series of holes of a defined and constant size of from about 1 mm to about 3 mm, separated from each other by a constant distance of from about 0.3 mm to about 5 mm, in embodiments, of from about 0.5 mm to about 2 mm. Such devices are hereafter referenced as perforated cellulose sheets. [0011] In embodiments, the devices described herein include two or more areas having different sets of perforations. (See Fig. 4) For example, a first area may have a first set of perforations having a first set of characteristics and a second area may have a second set of perforations having a second set of characteristics. Thus, a sheet having a first area perforated in one area as described in the previous paragraph may be perforated in another area to provide holes of a defined and constant size of from about 10 μm to about 100 μm, separated from each other by a constant distance of from about 100 μm to about 500 μm, in embodiments, of from about 100 μm to about 200 μm. [0012] In embodiments, the holes in the devices may not be simply ordered, but may be arranged according to more complex sequences. For example, the distance between holes may vary across the surface of the device. As another example, the sheet may include rows of closely spaced holes separated by some distance. In embodiments, a series of five rows of 100 μm diameter holes may be separated by each other at a distance of from about 200 μm to about 400 μm and this series of holes may be separated from another series of similarly sized and spaced rows by distance of from about 1 mm to about 5 mm. (See Fig. 3) [0013] According to the present disclosure, the holes of the perforated and microperforated cellulose sheets may have any shape or geometry. For example, the holes may be a circle, a square, a rectangle, an oval, or an ellipse. It should be understood that the use of other shapes or combinations of shapes are also contemplated. [0014] Continuous perforated or microperforated bacterial cellulose sheets may be prepared by any conventional methods known in the art. [0015] The perforated and microperforated cellulose sheets according to the present disclosure may be obtained using mechanical perforation devices such as suitably arranged punching machines. Alternatively, thermal or ultraviolet lasers operating in a frequency band such as to produce holes of the required size and distance apart in the cellulose sheet may be used. [0016] The perforated and microperforated cellulose sheets according to the present disclosure may also be obtained by other suitable processes, such as vacuum, needle or water jet perforation, hot pins, embossing, and combinations thereof.
[0017] In embodiments, perforation of the cellulose sheets may be performed on wet or dry materials. [0018] In embodiments, perforation of the cellulose sheets may be performed at the end of the fermentation process when the cellulose pellicles or films are harvested. In embodiments, perforation may be performed when the medical device is at the final processing stage. At this stage, the cellulose sheets may be perforated or microperforated, then cut to shape and sizes appropriate for the envisaged application. The cellulose sheets may be packaged in single or dual pouches and sterilized using conventional techniques, such as, but not limited to, irradiation with beta (electronic irradiation) or gamma (irradiation using radioactive cobalt) rays at about 25 KGy to about 35 KGy1 and/or sterilized by ethylene oxide. In embodiments where hydrolytically unstable materials are used in forming the implant, the cellulose sheets are packaged under sufficiently dry conditions to ensure that no degradation of the composite takes place during storage.
[0019] The present medical devices including bacterial cellulose sheets which are microperforated or perforated, may advantageously maintain one or more of the unique properties of bacterial cellulose sheets. For example, the present sheets may exhibit high biocompatibility, extreme hydrophilicity, a multi-layered three dimensional laminar structures providing excellent moisture handling properties, excellent wet strength, high resistance to breakdown under compression, conformability and the absence of generation of harmful particles of the cellulose mesh after rubbing against surrounding tissues or erosion at sharp edges of tissues (e.g., sharp edges of bone and cartilage tissues). [0020] The perforated bacterial cellulose sheets of the present disclosure may be used for the repair, reinforcing and/or replacement of soft tissues, such as for example, the abdominal wall and pelvic floor.
[0021] It will be understood that various modifications may be made to the embodiments disclosed herein. Thus, those skilled in the art will envision other modifications within the scope and spirit of the disclosure.

Claims

1. A medical device comprising a bacterial cellulose sheet having perforations.
2. The medical device of claim 1 , wherein the bacterial cellulose sheet has a thickness of from about 0.1 mm to about 5 mm.
3. The medical device of claim 1 or 2, wherein the perforations comprise holes of a size from about 10 μm and 100 μm, separated from each other by a distance of from about 0.1 mm to about 3 mm.
4. The medical device of claim 1 or 2, wherein the perforations comprise holes of a size of from about 1 mm to about 3 mm, separated from each other by a distance of from about 0.3 mm to about 5 mm.
5. The medical device of claim 1 or 2, wherein the perforations comprise holes of a size of from about 10 μm to about 100 μm, separated from each other by a distance of from about 100 μm to about 500 μm.
6. A medical device of any of claims 3-5, wherein the holes are arranged in an ordered series.
7. A medical device as in any one of claims 1-6, wherein the bacterial cellulose sheet comprises a first area having perforations and a second area containing no perforations.
8. A medical device as in any one of claims 1-7, wherein the bacterial cellulose sheet comprises a first area having perforations of a first size and a second area having perforations of a second size different from the first size.
9. A medical device as in any one of claims 1-8, wherein the bacterial cellulose sheet comprises a first area with perforations arranged in a first pattern and a second area with perforations arranged in a second pattern different from the first pattern.
10. A medical device as in any one of claims 1-9, wherein the perforations are circular.
11. A method of making a medical device comprising: providing a bacterial cellulose sheet; and perforating the bacterial cellulose sheet.
12. The method of claim 11 , wherein the bacterial cellulose sheet provided is derived from Acetobacter xylinum.
13. The method of claim 11 or 12, wherein the bacterial cellulose sheet provided comprises oxidized cellulose.
14. A method of any one of claims 11-13, wherein perforating the bacterial cellulose sheet forms holes of a size of from about 10 μm and 100 μm, separated from each other by a distance of from about 0.1 mm to about 3 mm.
15. A method of any one of claims 11-13, wherein perforating the bacterial cellulose sheet forms holes of a size of from about 1 mm to about 3 mm, separated from each other by a distance of from about 0.3 mm to about 5 mm,
16. A method of any one of claims 11-13, wherein perforating the bacterial cellulose sheet forms holes of a defined and constant size of from about 10 μm to about 100 μm, separated from each other by a constant distance of from about 100 μm to about 500 μm.
17. A method as in any of claims 14-16, wherein perforating the bacterial cellulose sheet forms an ordered series of holes.
18. A method as in any one of claims 11-17, wherein an area of the bacterial cellulose sheet remains imperforated.
19. A method as in any one of claims 11-18, wherein perforating is performed by a method selected from the group consisting of punching and laser drilling.
PCT/IB2009/007662 2008-11-07 2009-11-06 Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh WO2010052584A2 (en)

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AU2009312479A AU2009312479A1 (en) 2008-11-07 2009-11-06 Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh
CA2741518A CA2741518A1 (en) 2008-11-07 2009-11-06 Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh
US13/125,604 US20110262696A1 (en) 2008-11-07 2009-11-06 Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh
EP09801999A EP2349075A2 (en) 2008-11-07 2009-11-06 Medical device including a bacterial cellulose sheet, perforated or microperforated as a mesh

Applications Claiming Priority (2)

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US11232408P 2008-11-07 2008-11-07
US61/112,324 2008-11-07

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EP (1) EP2349075A2 (en)
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WO (1) WO2010052584A2 (en)

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DE102012003541A1 (en) 2012-02-21 2013-08-22 Jenpolymer Materials Ltd. & Co. Kg Bacterial nanocellulose body useful e.g. as transplant for in situ cell colonization and tissue formation, comprises channel-like pore structure, interconnecting multidimensional structure, and channel-shaped cavities with open cell wall
WO2018165131A1 (en) 2017-03-06 2018-09-13 Tei Biosciences, Inc. Perforated tissue graft
US10343385B2 (en) 2013-07-18 2019-07-09 Boston Scientific Scimed, Inc. Bodily implant
CN111655171A (en) * 2018-02-08 2020-09-11 泰尔茂株式会社 Medical device and healing promoting device using same

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KR20180045617A (en) 2016-10-26 2018-05-04 삼성전자주식회사 Recombinant microorganism including genetic modification that increases activity of pyruvate, phosphate dikinase and use thereof
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JP2020048952A (en) * 2018-09-27 2020-04-02 テルモ株式会社 Fusion promotion device
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