WO2010049952A3 - A novel process for the preparation of eletriptan - Google Patents

A novel process for the preparation of eletriptan Download PDF

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Publication number
WO2010049952A3
WO2010049952A3 PCT/IN2009/000614 IN2009000614W WO2010049952A3 WO 2010049952 A3 WO2010049952 A3 WO 2010049952A3 IN 2009000614 W IN2009000614 W IN 2009000614W WO 2010049952 A3 WO2010049952 A3 WO 2010049952A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
novel process
eletriptan
methylpyrrolidin
phenylsulfonyl
Prior art date
Application number
PCT/IN2009/000614
Other languages
French (fr)
Other versions
WO2010049952A2 (en
Inventor
Manik Reddy Pullagurla
Jagadeesh Babu Rangisetty
Neelam Naidu
Nagaraju Maddela
Radha Nagarapu
Pulla Rao Polagani
Original Assignee
Biophore India Pharmaceuticals Pvt. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biophore India Pharmaceuticals Pvt. Ltd. filed Critical Biophore India Pharmaceuticals Pvt. Ltd.
Priority to US12/998,522 priority Critical patent/US8633239B2/en
Priority to ES09823194T priority patent/ES2431359T3/en
Priority to EP09823194.7A priority patent/EP2349998B1/en
Publication of WO2010049952A2 publication Critical patent/WO2010049952A2/en
Publication of WO2010049952A3 publication Critical patent/WO2010049952A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The present invention relates to a novel process for the preparation of (R)-3-((1-methylpyrrolidin-2-yl)methyl)-5-(2-(phenylsulfonyl)ethyl)-1H-indole and its intermediates thereof.
PCT/IN2009/000614 2008-10-31 2009-10-29 A novel process for the preparation of 5-substituted indole derivatives WO2010049952A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
US12/998,522 US8633239B2 (en) 2008-10-31 2009-10-29 Process for the preparation of eletriptan
ES09823194T ES2431359T3 (en) 2008-10-31 2009-10-29 New procedure for the preparation of Eletriptan
EP09823194.7A EP2349998B1 (en) 2008-10-31 2009-10-29 A novel process for the preparation of eletriptan

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2654CH2008 2008-10-31
IN2654/CHE/2008 2008-10-31

Publications (2)

Publication Number Publication Date
WO2010049952A2 WO2010049952A2 (en) 2010-05-06
WO2010049952A3 true WO2010049952A3 (en) 2010-11-18

Family

ID=42129401

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000614 WO2010049952A2 (en) 2008-10-31 2009-10-29 A novel process for the preparation of 5-substituted indole derivatives

Country Status (4)

Country Link
US (1) US8633239B2 (en)
EP (1) EP2349998B1 (en)
ES (1) ES2431359T3 (en)
WO (1) WO2010049952A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102936240A (en) * 2012-10-30 2013-02-20 浙江省医学科学院 Synthetic method of (R)-5-substituted-3-(N-carbobenzoxy pyrrolidine-2-based carbonyl)-1H-benzpyrole
CN104230895B (en) * 2013-06-08 2017-02-08 上海医药工业研究院 Preparation method for eletriptan intermediate
CN103408534B (en) * 2013-08-13 2016-05-04 张家港威胜生物医药有限公司 The synthesis technique of eletriptan

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US6201131B1 (en) * 1999-03-24 2001-03-13 Sumitomo Chemical Company, Limited Process for producing [2-(arylsulfonyl) ethenyl] benzene derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030166704A1 (en) * 2000-12-20 2003-09-04 Pfizer Inc. New process
US20050103035A1 (en) * 2003-11-19 2005-05-19 Massachusetts Institute Of Technology Oil circulation observer for HVAC systems
WO2005103035A1 (en) 2004-04-23 2005-11-03 Pfizer Limited Modified fischer indole synthesis of eletriptan

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US6201131B1 (en) * 1999-03-24 2001-03-13 Sumitomo Chemical Company, Limited Process for producing [2-(arylsulfonyl) ethenyl] benzene derivatives

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Contemporary Drug Synthesis", 25 June 2004, WILEY-INTERSCIENCE, ISBN: 0471214809, XP008124053 *
HUMPHREY GUY R ET AL: "Practical methodologies for the synthesis of indoles.", CHEMICAL REVIEWS JUL 2006 LNKD- PUBMED:16836303, vol. 106, no. 7, July 2006 (2006-07-01), pages 2875 - 2911, XP002590412, ISSN: 0009-2665 *

Also Published As

Publication number Publication date
ES2431359T3 (en) 2013-11-26
EP2349998A2 (en) 2011-08-03
EP2349998B1 (en) 2013-07-17
US20110207943A1 (en) 2011-08-25
WO2010049952A2 (en) 2010-05-06
US8633239B2 (en) 2014-01-21

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