WO2010042747A3 - Fgf21 mutants and uses thereof - Google Patents

Fgf21 mutants and uses thereof Download PDF

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Publication number
WO2010042747A3
WO2010042747A3 PCT/US2009/060045 US2009060045W WO2010042747A3 WO 2010042747 A3 WO2010042747 A3 WO 2010042747A3 US 2009060045 W US2009060045 W US 2009060045W WO 2010042747 A3 WO2010042747 A3 WO 2010042747A3
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WO
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Application
Patent type
Prior art keywords
uses
fgf21 mutant
fgf21 mutants
polypeptides
mutant polypeptides
Prior art date
Application number
PCT/US2009/060045
Other languages
French (fr)
Other versions
WO2010042747A2 (en )
Inventor
Kenneth W. Walker
Colin V. Gegg, Jr.
Randy I. Hecht
Edward J. Belouski
Yue-Sheng Li
Mark L. Michaels
Jing Xu
Murielle M. Ellison
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/50Fibroblast growth factors [FGF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Abstract

The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
PCT/US2009/060045 2008-10-10 2009-10-08 Fgf21 mutants and uses thereof WO2010042747A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US19576108 true 2008-10-10 2008-10-10
US61/195,761 2008-10-10

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
CN 200980150308 CN102625811B (en) 2008-10-10 2009-10-08 Fgf21 mutant and its use
JP2011531178A JP5878757B2 (en) 2008-10-10 2009-10-08 Fgf21 variants and their use
CA 2739615 CA2739615C (en) 2008-10-10 2009-10-08 Fgf21 mutants comprising polyethylene glycol and uses thereof
US13123205 US9279013B2 (en) 2008-10-10 2009-10-08 FGF-21 mutants comprising polyethylene glycol and uses thereof
EP20090748878 EP2358749B1 (en) 2008-10-10 2009-10-08 Fgf21 mutants and uses thereof
US15007438 US20160244497A1 (en) 2008-10-10 2016-01-27 Fgf21 mutants and uses thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US201113123205 A-371-Of-International 2011-04-07 2011-04-07
US15007438 Continuation US20160244497A1 (en) 2008-10-10 2016-01-27 Fgf21 mutants and uses thereof

Publications (2)

Publication Number Publication Date
WO2010042747A2 true WO2010042747A2 (en) 2010-04-15
WO2010042747A3 true true WO2010042747A3 (en) 2010-06-17

Family

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Family Applications (1)

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PCT/US2009/060045 WO2010042747A3 (en) 2008-10-10 2009-10-08 Fgf21 mutants and uses thereof

Country Status (7)

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US (2) US9279013B2 (en)
EP (1) EP2358749B1 (en)
JP (2) JP5878757B2 (en)
KR (1) KR101651703B1 (en)
CN (1) CN102625811B (en)
CA (1) CA2739615C (en)
WO (1) WO2010042747A3 (en)

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