WO2010030670A3 - Compositions and methods for the prevention of oxidative degradation of proteins - Google Patents

Compositions and methods for the prevention of oxidative degradation of proteins Download PDF

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Publication number
WO2010030670A3
WO2010030670A3 PCT/US2009/056365 US2009056365W WO2010030670A3 WO 2010030670 A3 WO2010030670 A3 WO 2010030670A3 US 2009056365 W US2009056365 W US 2009056365W WO 2010030670 A3 WO2010030670 A3 WO 2010030670A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
prevention
compositions
methods
oxidation
Prior art date
Application number
PCT/US2009/056365
Other languages
French (fr)
Other versions
WO2010030670A2 (en
Inventor
Junyan A. Ji
Yuchang John Wang
Boyan Zhang
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Priority to BRPI0918978A priority Critical patent/BRPI0918978A2/en
Priority to EP09792371A priority patent/EP2334323A2/en
Priority to CA2734275A priority patent/CA2734275A1/en
Priority to CN2009801445283A priority patent/CN102209554A/en
Priority to JP2011526940A priority patent/JP5705115B2/en
Priority to AU2009291865A priority patent/AU2009291865A1/en
Priority to MX2011002372A priority patent/MX2011002372A/en
Publication of WO2010030670A2 publication Critical patent/WO2010030670A2/en
Publication of WO2010030670A3 publication Critical patent/WO2010030670A3/en
Priority to IL211234A priority patent/IL211234A0/en
Priority to IL229180A priority patent/IL229180A0/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4415—Pyridoxine, i.e. Vitamin B6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2833—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against MHC-molecules, e.g. HLA-molecules

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The invention relates to pharmaceutical formulations comprising a protein and free methionine in combination with one or more compounds capable of preventing the oxidation of aromatic amino acid residues within a protein. More specifically, the invention relates to stabilized, pharmaceutically effective preparations of oxidation-sensitive therapeutic agents. The invention further relates to a method of inhibiting the oxidation of such therapeutic agents.
PCT/US2009/056365 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins WO2010030670A2 (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
BRPI0918978A BRPI0918978A2 (en) 2008-09-10 2009-09-09 compositions and methods the prevention of oxidative degradation of proteins
EP09792371A EP2334323A2 (en) 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins
CA2734275A CA2734275A1 (en) 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins
CN2009801445283A CN102209554A (en) 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins
JP2011526940A JP5705115B2 (en) 2008-09-10 2009-09-09 Compositions and methods for prevention of oxidative degradation of proteins
AU2009291865A AU2009291865A1 (en) 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins
MX2011002372A MX2011002372A (en) 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins.
IL211234A IL211234A0 (en) 2008-09-10 2011-02-15 Compositions and methods for the prevention of oxidative degradation of proteins
IL229180A IL229180A0 (en) 2008-09-10 2013-10-31 Compositions and methods for the prevention of oxidative degradation of proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9587808P 2008-09-10 2008-09-10
US61/095,878 2008-09-10

Related Child Applications (1)

Application Number Title Priority Date Filing Date
EP12178248.6A Previously-Filed-Application EP2684570A1 (en) 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins

Publications (2)

Publication Number Publication Date
WO2010030670A2 WO2010030670A2 (en) 2010-03-18
WO2010030670A3 true WO2010030670A3 (en) 2010-05-06

Family

ID=41351722

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/056365 WO2010030670A2 (en) 2008-09-10 2009-09-09 Compositions and methods for the prevention of oxidative degradation of proteins

Country Status (11)

Country Link
US (2) US20100068210A1 (en)
EP (2) EP2684570A1 (en)
JP (2) JP5705115B2 (en)
KR (1) KR20110076918A (en)
CN (2) CN102209554A (en)
AU (1) AU2009291865A1 (en)
BR (1) BRPI0918978A2 (en)
CA (1) CA2734275A1 (en)
IL (2) IL211234A0 (en)
MX (1) MX2011002372A (en)
WO (1) WO2010030670A2 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101939557B1 (en) 2008-10-17 2019-01-17 사노피-아벤티스 도이칠란트 게엠베하 Combination of an insulin and a GLP-1 agonist
PT3345593T (en) 2009-11-13 2023-11-27 Sanofi Aventis Deutschland Pharmaceutical composition comprising despro36exendin-4(1-39)-lys6-nh2 and methionine
CN107308442B (en) 2009-11-13 2022-10-18 赛诺菲-安万特德国有限公司 Pharmaceutical composition comprising a GLP-1 agonist, insulin and methionine
EP2364690A1 (en) * 2010-02-12 2011-09-14 Centro De Ingenieria Genetica Y Biotecnologia Orally administrable pharmaceutical pellet of epidermal growth factor
BR112012021873B8 (en) * 2010-03-22 2021-09-14 Genentech Inc composition of matter, article of manufacture, methods for preparing a composition, for increasing the stability of a protein in polysorbate-free aqueous solution and for preventing or reducing aggregation of a protein in polysorbate-free aqueous solution
LT2611458T (en) 2010-08-30 2016-12-27 Sanofi-Aventis Deutschland Gmbh Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
KR101913874B1 (en) * 2010-11-10 2018-10-31 인리젠 Injectable formulations for organ augmentation
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
US20140088014A1 (en) 2011-06-07 2014-03-27 Asahi Kasei Pharma Corporation Freeze-dried preparation containing high-purity pth and method for producing same
MX370264B (en) 2011-08-29 2019-12-09 Sanofi Aventis Deutschland Pharmaceutical combination for use in glycemic control in diabetes type 2 patients.
AR087744A1 (en) 2011-09-01 2014-04-16 Sanofi Aventis Deutschland PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT OF A NEURODEGENERATIVE DISEASE
ES2693508T3 (en) * 2011-10-26 2018-12-12 Amgen Inc. Methods to reduce or eliminate protein modification and degradation due to exposure to UV light
TWI641381B (en) 2013-02-04 2018-11-21 法商賽諾菲公司 Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
WO2014160495A1 (en) * 2013-03-13 2014-10-02 Genentech, Inc. Formulations with reduced oxidation
US10653779B2 (en) 2013-03-13 2020-05-19 Genentech, Inc. Formulations with reduced oxidation
WO2014160371A1 (en) * 2013-03-13 2014-10-02 Eleven Biotherapeutics, Inc. Chimeric cytokine formulations for ocular delivery
US20140314778A1 (en) * 2013-03-13 2014-10-23 Genentech, Inc. Formulations with reduced oxidation
CA2904169C (en) * 2013-03-13 2021-12-07 Genentech, Inc. Formulations with reduced oxidation
KR102202476B1 (en) 2013-03-15 2021-01-12 제넨테크, 인크. Cell culture media and methods of antibody production
BR112016013832A2 (en) 2014-01-09 2017-08-08 Sanofi Sa USE OF INSULIN ANALOG AND/OR DERIVATIVE, PHARMACEUTICAL FORMULATION AND PROCESS FOR THE PREPARATION OF THE SAME, KIT AND MEDICAL DEVICE
EP3091995B1 (en) 2014-01-09 2024-03-20 Sanofi Stabilized pharmaceutical formulations of insulin aspart
JP6735674B2 (en) 2014-01-09 2020-08-05 サノフイＳａｎｏｆｉ Stabilized pharmaceutical formulation of insulin aspart
SI3229828T1 (en) 2014-12-12 2023-06-30 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (en) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 Treatment type 2 diabetes mellitus patients
TW201705975A (en) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 Treatment of type 2 diabetes mellitus patients
WO2017049205A2 (en) * 2015-09-18 2017-03-23 Amunix Operating Inc. Growth hormone formulation
JP6703098B2 (en) 2016-03-31 2020-06-03 富士フイルム株式会社 Semiconductor manufacturing treatment liquid and pattern forming method
US11142553B2 (en) 2016-11-29 2021-10-12 Spiber Inc. Protein composition, method for producing same and method for improving heat stability
MA50266A (en) * 2017-09-22 2020-07-29 Immunogen Inc METHODS FOR PREVENTING THE OXIDATION OF METHIONINE IN IMMUNOCONJUGATES
JP6577683B2 (en) * 2017-09-22 2019-09-18 旭化成ファーマ株式会社 Liquid pharmaceutical composition containing teriparatide having excellent stability
JP2019156805A (en) * 2018-03-16 2019-09-19 ナガセ医薬品株式会社 Container filling human pth(1-34) liquid pharmaceutical composition, and method for manufacturing the same
CA3107077A1 (en) * 2018-08-07 2020-02-13 Glaxosmithkline Biologicals Sa Processes and vaccines
TW202019478A (en) 2018-08-08 2020-06-01 美商建南德克公司 Use of tryptophan derivatives and L-methionine for protein formulation
JP2020052012A (en) * 2018-09-28 2020-04-02 株式会社Ｌｓｉメディエンス Immunoassay reagent using insoluble carrier
CN112451652A (en) * 2020-12-07 2021-03-09 苏州智核生物医药科技有限公司 Recombinant human thyrotropin injection

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1197221A1 (en) * 1999-03-01 2002-04-17 Chugai Seiyaku Kabushiki Kaisha Preparations stabilized over long time
EP1260230A1 (en) * 2000-02-29 2002-11-27 Chugai Seiyaku Kabushiki Kaisha Preparations stabilized over long time

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515893A (en) 1979-04-26 1985-05-07 Ortho Pharmaceutical Corporation Hybrid cell line for producing complement-fixing monoclonal antibody to human T cells
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5091178A (en) 1986-02-21 1992-02-25 Oncogen Tumor therapy with biologically active anti-tumor antibodies
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
US5091313A (en) 1988-08-05 1992-02-25 Tanox Biosystems, Inc. Antigenic epitopes of IgE present on B cell but not basophil surface
US5720937A (en) 1988-01-12 1998-02-24 Genentech, Inc. In vivo tumor detection assay
WO1989012463A1 (en) 1988-06-21 1989-12-28 Genentech, Inc. Method and therapeutic compositions for the treatment of myocardial infarction
US5078997A (en) * 1988-07-13 1992-01-07 Cetus Corporation Pharmaceutical composition for interleukin-2 containing physiologically compatible stabilizers
US5272135A (en) * 1991-03-01 1993-12-21 Chiron Ophthalmics, Inc. Method for the stabilization of methionine-containing polypeptides
EP0602126B1 (en) 1991-08-14 2003-03-05 Genentech, Inc. Immunoglobulin variants for specific fc epsilon receptors
US5849700A (en) * 1991-12-20 1998-12-15 Novo Nordisk A/S Pharmaceutical formulation
WO1994004188A1 (en) 1992-08-21 1994-03-03 Genentech, Inc. Method for treating an lfa-1-mediated disorder
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
US5595721A (en) 1993-09-16 1997-01-21 Coulter Pharmaceutical, Inc. Radioimmunotherapy of lymphoma using anti-CD20
US5714338A (en) 1993-12-10 1998-02-03 Genentech, Inc. Methods for diagnosis of allergy
MX9602818A (en) 1994-01-18 1997-06-28 Genentech Inc A METHOD OF TREATMENT OF PARASITIC INFECTION USING IgE ANTAGONISTS.
WO1995023865A1 (en) 1994-03-03 1995-09-08 Genentech, Inc. Anti-il-8 monoclonal antibodies for treatment of inflammatory disorders
IL117645A (en) 1995-03-30 2005-08-31 Genentech Inc Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
AU6267896A (en) 1995-06-07 1996-12-30 Imclone Systems Incorporated Antibody and antibody fragments for inhibiting the growth oftumors
EP1297847A3 (en) 1996-01-23 2003-05-07 Genentech, Inc. Anti-CD18 antibodies in stroke
US7147851B1 (en) 1996-08-15 2006-12-12 Millennium Pharmaceuticals, Inc. Humanized immunoglobulin reactive with α4β7 integrin
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
DK0941344T3 (en) 1996-11-27 2004-09-27 Genentech Inc Humanized anti-CD11a antibodies
DE69829891T2 (en) 1997-04-07 2005-10-06 Genentech, Inc., South San Francisco Anti-VEGF antibody
DE69838249T3 (en) 1997-05-15 2012-01-19 Genentech, Inc. ANTI-APO-2 ANTIBODIES
JP5149470B2 (en) * 1999-02-22 2013-02-20 バクスター・インターナショナル・インコーポレイテッド Novel factor VIII formulation without albumin
JP3062493B1 (en) * 1999-03-19 2000-07-10 明治乳業株式会社 Bifidus factor photodegradation inhibitor
CH694589A5 (en) 1999-06-25 2005-04-15 Genentech Inc Humanized anti-ErbB2 antibodies and treatment with anti-ErbB2 antibodies.
AU778199B2 (en) 1999-10-29 2004-11-25 Genentech Inc. Anti-prostate stem cell antigen (PSCA) antibody compositions and methods of use
UA83458C2 (en) 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. The isolated polypeptide baff-r (the receptor of the factor of activation of b-cells of the family tnf)
US6989138B2 (en) * 2000-10-24 2006-01-24 Diatide, Inc. Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans
ATE355087T1 (en) * 2000-10-24 2006-03-15 Cis Bio Int STABILIZATION OF RADIOPHARMACEUTICAL COMPOSITIONS WITH A HYDROPHILIC THIOETHER OR A HYDROPHILIC 6-HYDROXY-CHROMANE
US7321026B2 (en) 2001-06-27 2008-01-22 Skytech Technology Limited Framework-patched immunoglobulins
US20030104996A1 (en) * 2001-08-30 2003-06-05 Tiansheng Li L-methionine as a stabilizer for NESP/EPO in HSA-free formulations
EP1507793A4 (en) 2001-10-17 2006-02-01 Human Genome Sciences Inc Neutrokine-alpha and neutrokine-alpha splice variant
US20040093621A1 (en) 2001-12-25 2004-05-13 Kyowa Hakko Kogyo Co., Ltd Antibody composition which specifically binds to CD20
EP2295468B1 (en) 2002-02-14 2015-07-08 Immunomedics, Inc. Anti-CD20 antibodies and fusion proteins thereof and methods of use
CA2502552C (en) 2002-10-17 2019-02-12 Genmab A/S Human monoclonal antibodies against cd20
EP1944320A1 (en) 2002-12-16 2008-07-16 Genentech, Inc. Immunoglobulin variants and uses thereof
WO2005000901A2 (en) 2003-05-09 2005-01-06 Duke University Cd20-specific antibodies and methods of employing same
AR044388A1 (en) 2003-05-20 2005-09-07 Applied Molecular Evolution CD20 UNION MOLECULES
EP1651663B1 (en) 2003-08-08 2017-05-17 Immunomedics, Inc. Bispecific antibodies for inducing apoptosis of tumor and diseased cells
US8147832B2 (en) 2003-08-14 2012-04-03 Merck Patent Gmbh CD20-binding polypeptide compositions and methods
GT200600031A (en) * 2005-01-28 2006-08-29 ANTI-BETA ANTIBODY FORMULATION
AU2006262603B2 (en) 2005-06-20 2011-01-06 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
EP2212432A4 (en) * 2007-10-22 2011-10-19 Schering Corp Fully human anti-vegf antibodies and methods of using
EP3381445B1 (en) * 2007-11-15 2023-10-25 Amgen Inc. Aqueous formulation of antibody stablised by antioxidants for parenteral administration
WO2015198451A1 (en) 2014-06-26 2015-12-30 楽天株式会社 Information-processing device, information-processing method, and information-processing program

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1197221A1 (en) * 1999-03-01 2002-04-17 Chugai Seiyaku Kabushiki Kaisha Preparations stabilized over long time
EP1700605A2 (en) * 1999-03-01 2006-09-13 Chugai Seiyaku Kabushiki Kaisha Lyophilized methionine-containing protein preparations stabilized over long time
EP1260230A1 (en) * 2000-02-29 2002-11-27 Chugai Seiyaku Kabushiki Kaisha Preparations stabilized over long time

Also Published As

Publication number Publication date
JP2012502102A (en) 2012-01-26
WO2010030670A2 (en) 2010-03-18
US20100068210A1 (en) 2010-03-18
BRPI0918978A2 (en) 2015-12-01
EP2334323A2 (en) 2011-06-22
JP2015107973A (en) 2015-06-11
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AU2009291865A1 (en) 2010-03-18
CA2734275A1 (en) 2010-03-18
EP2684570A1 (en) 2014-01-15
KR20110076918A (en) 2011-07-06
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CN103599541A (en) 2014-02-26
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