WO2009152392A3 - Muscarinic agonists for neurological disorders and methods of making the same - Google Patents

Muscarinic agonists for neurological disorders and methods of making the same Download PDF

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Publication number
WO2009152392A3
WO2009152392A3 PCT/US2009/047124 US2009047124W WO2009152392A3 WO 2009152392 A3 WO2009152392 A3 WO 2009152392A3 US 2009047124 W US2009047124 W US 2009047124W WO 2009152392 A3 WO2009152392 A3 WO 2009152392A3
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WO
Grant status
Application
Patent type
Prior art keywords
making
methods
same
ring
neurological disorders
Prior art date
Application number
PCT/US2009/047124
Other languages
French (fr)
Other versions
WO2009152392A2 (en )
Inventor
William S. Messer, Jr.
Aditya Maheshwari
Original Assignee
University Of Toledo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Muscarinic receptors with agonist activity and methods of making the same are disclosed. The compound have a thiadiazole compound having a having a quinuclidine ring, a tetrahydropyridine ring, an azobicyclo-heptane ring; or, an azobicyclo-octane ring, wherein a linking group replaces an alkyl sulfonate moiety of the thiadiazole compound.
PCT/US2009/047124 2008-06-11 2009-06-11 Muscarinic agonists for neurological disorders and methods of making the same WO2009152392A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US6079408 true 2008-06-11 2008-06-11
US61/060,794 2008-06-11

Publications (2)

Publication Number Publication Date
WO2009152392A2 true WO2009152392A2 (en) 2009-12-17
WO2009152392A3 true true WO2009152392A3 (en) 2010-02-04

Family

ID=41417403

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/047124 WO2009152392A3 (en) 2008-06-11 2009-06-11 Muscarinic agonists for neurological disorders and methods of making the same

Country Status (1)

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WO (1) WO2009152392A3 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101440529B1 (en) * 2011-03-18 2014-09-17 주식회사 엘지화학 Method of preparing dinitrile compounds

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414009A (en) * 1992-01-13 1995-05-09 Novo Nordisk A/S Azabicyclo substituted oxa- or thia-diazole compounds
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US6211204B1 (en) * 1999-01-22 2001-04-03 University Of Toledo Muscarinic receptor agonists
US20010036953A1 (en) * 1999-01-22 2001-11-01 Messer William S. Muscarinic receptor agonists
US20030069290A1 (en) * 2001-08-24 2003-04-10 Wishka Donn G. Substituted-heteroaryl-7-aza[2.2.1] bycycloheptanes for the treatment of desease
US7361668B2 (en) * 2001-10-17 2008-04-22 Ucb, S.A. Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors
US20080108618A1 (en) * 1998-03-31 2008-05-08 Mark Brann Compounds with activity on muscarinic receptors

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5414009A (en) * 1992-01-13 1995-05-09 Novo Nordisk A/S Azabicyclo substituted oxa- or thia-diazole compounds
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US20080108618A1 (en) * 1998-03-31 2008-05-08 Mark Brann Compounds with activity on muscarinic receptors
US6211204B1 (en) * 1999-01-22 2001-04-03 University Of Toledo Muscarinic receptor agonists
US20010036953A1 (en) * 1999-01-22 2001-11-01 Messer William S. Muscarinic receptor agonists
US20030069290A1 (en) * 2001-08-24 2003-04-10 Wishka Donn G. Substituted-heteroaryl-7-aza[2.2.1] bycycloheptanes for the treatment of desease
US7361668B2 (en) * 2001-10-17 2008-04-22 Ucb, S.A. Quinuclidine derivatives processes for preparing them and their uses as m2 and/or m3 muscarinic receptor inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTOPOULOS ET AL.: "Synthesis and Pharmacological Evaluation of Dimeric Muscarinic Acetylcholine Receptor Agonists", THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, vol. 298, no. 3, September 2001 (2001-09-01), pages 1260 - 1268 *

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WO2009152392A2 (en) 2009-12-17 application

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