WO2009140626A3 - Long term disease modification using immunostimulatory oligonucleotides - Google Patents

Long term disease modification using immunostimulatory oligonucleotides Download PDF

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Publication number
WO2009140626A3
WO2009140626A3 PCT/US2009/044192 US2009044192W WO2009140626A3 WO 2009140626 A3 WO2009140626 A3 WO 2009140626A3 US 2009044192 W US2009044192 W US 2009044192W WO 2009140626 A3 WO2009140626 A3 WO 2009140626A3
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WO
WIPO (PCT)
Prior art keywords
long term
term disease
disease modification
immunostimulatory oligonucleotides
modification
Prior art date
Application number
PCT/US2009/044192
Other languages
French (fr)
Other versions
WO2009140626A2 (en
Inventor
Edith M. Hessel
Robert L. Coffman
Original Assignee
Dynavax Technologies Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dynavax Technologies Corporation filed Critical Dynavax Technologies Corporation
Priority to CA2724418A priority Critical patent/CA2724418A1/en
Priority to EP09747707.9A priority patent/EP2300102B1/en
Priority to US12/992,590 priority patent/US8815817B2/en
Priority to JP2011509763A priority patent/JP5727367B2/en
Priority to AU2009246169A priority patent/AU2009246169B2/en
Publication of WO2009140626A2 publication Critical patent/WO2009140626A2/en
Publication of WO2009140626A3 publication Critical patent/WO2009140626A3/en
Priority to HK11109929.4A priority patent/HK1155681A1/en
Priority to US14/335,790 priority patent/US9333254B2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/35—Allergens
    • A61K39/36—Allergens from pollen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0387—Animal model for diseases of the immune system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Pulmonology (AREA)
  • Zoology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
PCT/US2009/044192 2008-05-15 2009-05-15 Long term disease modification using immunostimulatory oligonucleotides WO2009140626A2 (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2724418A CA2724418A1 (en) 2008-05-15 2009-05-15 Long term disease modification using immunostimulatory oligonucleotides
EP09747707.9A EP2300102B1 (en) 2008-05-15 2009-05-15 Immunostimulatory sequences containing CpG for use in the treatment of allergic rhinitis
US12/992,590 US8815817B2 (en) 2008-05-15 2009-05-15 Long term disease modification using immunostimulatory oligonucleotides
JP2011509763A JP5727367B2 (en) 2008-05-15 2009-05-15 Long-term disease improvement using immunostimulatory oligonucleotides
AU2009246169A AU2009246169B2 (en) 2008-05-15 2009-05-15 Long term disease modification using immunostimulatory oligonucleotides
HK11109929.4A HK1155681A1 (en) 2008-05-15 2011-09-21 Immunostimulatory sequences containing cpg for use in the treatment of allergic rhinitis cpg
US14/335,790 US9333254B2 (en) 2008-05-15 2014-07-18 Long term disease modification using immunostimulatory oligonucleotides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5360508P 2008-05-15 2008-05-15
US61/053,605 2008-05-15

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/992,590 A-371-Of-International US8815817B2 (en) 2008-05-15 2009-05-15 Long term disease modification using immunostimulatory oligonucleotides
US14/335,790 Division US9333254B2 (en) 2008-05-15 2014-07-18 Long term disease modification using immunostimulatory oligonucleotides

Publications (2)

Publication Number Publication Date
WO2009140626A2 WO2009140626A2 (en) 2009-11-19
WO2009140626A3 true WO2009140626A3 (en) 2010-01-07

Family

ID=41258402

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/044192 WO2009140626A2 (en) 2008-05-15 2009-05-15 Long term disease modification using immunostimulatory oligonucleotides

Country Status (7)

Country Link
US (2) US8815817B2 (en)
EP (1) EP2300102B1 (en)
JP (1) JP5727367B2 (en)
AU (1) AU2009246169B2 (en)
CA (1) CA2724418A1 (en)
HK (1) HK1155681A1 (en)
WO (1) WO2009140626A2 (en)

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CN100334228C (en) * 2001-06-21 2007-08-29 戴纳瓦克斯技术公司 Cimeric immunomodulatory compounds and methods of using the same
NZ561144A (en) * 2005-03-04 2009-09-25 Dynavax Tech Corp Vaccines comprising oligonucleotides having immunostimulatory sequences (ISS) wherein the ISS are conjugated to antigens and stabilized by buffer conditions and further excipients
EP2300102B1 (en) 2008-05-15 2014-01-08 Dynavax Technologies Corporation Immunostimulatory sequences containing CpG for use in the treatment of allergic rhinitis
AU2010270714B2 (en) 2009-07-06 2015-08-13 Wave Life Sciences Ltd. Novel nucleic acid prodrugs and methods use thereof
EP2620428B1 (en) 2010-09-24 2019-05-22 Wave Life Sciences Ltd. Asymmetric auxiliary group
MX2013012593A (en) 2011-04-29 2014-08-21 Selecta Biosciences Inc Tolerogenic synthetic nanocarriers to reduce antibody responses.
US10946568B2 (en) 2011-06-09 2021-03-16 Rimtec Corporation Field joint coating material and a process for making a field joint
SG10201700554VA (en) 2011-07-19 2017-03-30 Wave Life Sciences Pte Ltd Methods for the synthesis of functionalized nucleic acids
JP5800263B2 (en) * 2011-09-27 2015-10-28 学校法人兵庫医科大学 Screening method for therapeutic agent for allergic rhinitis and use thereof
SG11201500239VA (en) 2012-07-13 2015-03-30 Wave Life Sciences Japan Asymmetric auxiliary group
KR20220025907A (en) 2013-05-03 2022-03-03 셀렉타 바이오사이언시즈, 인크. Tolerogenic synthetic nanocarriers to reduce or prevent anaphylaxis in response to a non-allergenic antigen
JPWO2015108046A1 (en) * 2014-01-15 2017-03-23 株式会社新日本科学 Chiral nucleic acid adjuvant and antiallergic agent having antiallergic action
MX2017002931A (en) 2014-09-07 2017-05-30 Selecta Biosciences Inc Methods and compositions for attenuating anti-viral transfer vector immune responses.
US20180071394A1 (en) * 2016-08-25 2018-03-15 Selecta Biosciences, Inc. Polyester polymer matrices for the delivery of allergens
KR20190124295A (en) 2017-03-11 2019-11-04 셀렉타 바이오사이언시즈, 인크. Methods and compositions related to combination treatment with synthetic nanocarriers comprising anti-inflammatory agents and immunosuppressants

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Also Published As

Publication number Publication date
US9333254B2 (en) 2016-05-10
HK1155681A1 (en) 2012-05-25
JP5727367B2 (en) 2015-06-03
EP2300102A2 (en) 2011-03-30
EP2300102B1 (en) 2014-01-08
AU2009246169A1 (en) 2009-11-19
US20150024007A1 (en) 2015-01-22
AU2009246169B2 (en) 2015-01-22
JP2011520916A (en) 2011-07-21
CA2724418A1 (en) 2009-11-19
WO2009140626A2 (en) 2009-11-19
US20110118341A1 (en) 2011-05-19
US8815817B2 (en) 2014-08-26

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