WO2009136412A3 - PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF - Google Patents

PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF Download PDF

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Publication number
WO2009136412A3
WO2009136412A3 PCT/IN2009/000250 IN2009000250W WO2009136412A3 WO 2009136412 A3 WO2009136412 A3 WO 2009136412A3 IN 2009000250 W IN2009000250 W IN 2009000250W WO 2009136412 A3 WO2009136412 A3 WO 2009136412A3
Authority
WO
WIPO (PCT)
Prior art keywords
oxobutyl
hydroxydiphenylmethyl
piperidinyl
acetic acid
preparation
Prior art date
Application number
PCT/IN2009/000250
Other languages
French (fr)
Other versions
WO2009136412A2 (en
Inventor
Siva Ram Prasad Vellanki
Dnyandev Ragho Rane
Narendra Dattatraya Mane
Venkateswar Rao Katragadda
Ramesh Kumar Sabbam
Debashish Datta
Original Assignee
Matrix Laboratories Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Matrix Laboratories Limited filed Critical Matrix Laboratories Limited
Publication of WO2009136412A2 publication Critical patent/WO2009136412A2/en
Publication of WO2009136412A3 publication Critical patent/WO2009136412A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Abstract

The present invention provides an improved process for preparing fexofenadine, its pharmaceutically acceptable salts and solvates thereof, the process comprising reacting methyl-4-(4-halo-1-oxobutyl]-α,α-dimethylphenyl acetate with α,α-diphenyl-4-piperidinemethanol in an alkyl nitrile solvent to prepare 4-[4-(4- (hydroxydiphenylmethyl)-1-piperidinyl]-1-oxobutyl]-α,α,-dimethylbenzene acetic acid alkyl ester, which is further converted into fexofenadine.
PCT/IN2009/000250 2008-04-25 2009-04-23 PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF WO2009136412A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN1027/CHE/2008 2008-04-25
IN1027CH2008 2008-04-25

Publications (2)

Publication Number Publication Date
WO2009136412A2 WO2009136412A2 (en) 2009-11-12
WO2009136412A3 true WO2009136412A3 (en) 2010-03-25

Family

ID=41265118

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2009/000250 WO2009136412A2 (en) 2008-04-25 2009-04-23 PROCESS FOR PREPARATION OF 4-[4-(4-(HYDROXYDIPHENYLMETHYL)- 1-PIPERIDINYL]-1-OXOBUTYL]-α,α-DIMETHYLBENZENE ACETIC ACID METHYL ESTER AND USE THEREOF

Country Status (1)

Country Link
WO (1) WO2009136412A2 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995000480A1 (en) * 1993-06-25 1995-01-05 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
US5750703A (en) * 1993-06-24 1998-05-12 Albany Molecular Research, Inc. Piperidine derivatives and process for their production
WO2002080857A2 (en) * 2001-04-09 2002-10-17 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
WO2005019175A1 (en) * 2003-08-26 2005-03-03 Cipla Limited Fexofenadine polymorphs and processes of preparing the same
WO2007007347A1 (en) * 2005-07-07 2007-01-18 Wockhardt Limited Industrial process of fexofenadine hydrochloride with controlled side products

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750703A (en) * 1993-06-24 1998-05-12 Albany Molecular Research, Inc. Piperidine derivatives and process for their production
WO1995000480A1 (en) * 1993-06-25 1995-01-05 Merrell Pharmaceuticals Inc. Novel intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives
WO2002080857A2 (en) * 2001-04-09 2002-10-17 Teva Pharmaceutical Industries Ltd. Polymorphs of fexofenadine hydrochloride
WO2005019175A1 (en) * 2003-08-26 2005-03-03 Cipla Limited Fexofenadine polymorphs and processes of preparing the same
WO2007007347A1 (en) * 2005-07-07 2007-01-18 Wockhardt Limited Industrial process of fexofenadine hydrochloride with controlled side products

Also Published As

Publication number Publication date
WO2009136412A2 (en) 2009-11-12

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