WO2009134947A1 - Nicotine lozenge compositions - Google Patents
Nicotine lozenge compositions Download PDFInfo
- Publication number
- WO2009134947A1 WO2009134947A1 PCT/US2009/042190 US2009042190W WO2009134947A1 WO 2009134947 A1 WO2009134947 A1 WO 2009134947A1 US 2009042190 W US2009042190 W US 2009042190W WO 2009134947 A1 WO2009134947 A1 WO 2009134947A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- nicotine
- lozenge
- oral
- oral lozenge
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
Definitions
- Figure 3 depicts the nicotine plasma concentration of a lozenge of the present invention (Example 1 ) versus that of a traditional lozenge (Example 2) in healthy smokers.
- Figure 3 demonstrates the bioequivalence of a formulation of the present invention versus the formulation of a traditional lozenge.
- the extent (Cmax) and total exposure (AUC) of nicotine delivered by the current invention is the same as that delivered by a traditional lozenge.
- Example 2 is a traditional lozenge composition wherein all buffering agents are present in the master granules.
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BRPI0911847A BRPI0911847B8 (en) | 2008-05-01 | 2009-04-30 | nicotine gum compositions |
EP09739749.1A EP2285411B1 (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions |
ES09739749.1T ES2605244T3 (en) | 2008-05-01 | 2009-04-30 | Nicotine Pill Compositions |
MX2010011929A MX2010011929A (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions. |
US12/990,049 US8501164B2 (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions |
DK09739749.1T DK2285411T3 (en) | 2008-05-01 | 2009-04-30 | Nicotine Tablet Compositions |
CN200980125040.6A CN102076362B (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions |
AU2009243065A AU2009243065B2 (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions |
CA 2723011 CA2723011A1 (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions |
JP2011507628A JP5893405B2 (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge composition |
HK11107381.9A HK1153146A1 (en) | 2008-05-01 | 2011-07-15 | Nicotine lozenge compositions |
US13/927,163 US8940772B2 (en) | 2008-05-01 | 2013-06-26 | Nicotine lozenge composition |
US14/572,953 US20150105431A1 (en) | 2008-05-01 | 2014-12-17 | Nicotine Lozenge Composition |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4951508P | 2008-05-01 | 2008-05-01 | |
US61/049,515 | 2008-05-01 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/990,049 A-371-Of-International US8501164B2 (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions |
US13/927,163 Continuation US8940772B2 (en) | 2008-05-01 | 2013-06-26 | Nicotine lozenge composition |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009134947A1 true WO2009134947A1 (en) | 2009-11-05 |
Family
ID=41255405
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2009/042190 WO2009134947A1 (en) | 2008-05-01 | 2009-04-30 | Nicotine lozenge compositions |
Country Status (19)
Country | Link |
---|---|
US (3) | US8501164B2 (en) |
EP (1) | EP2285411B1 (en) |
JP (2) | JP5893405B2 (en) |
CN (1) | CN102076362B (en) |
AR (1) | AR071420A1 (en) |
AU (1) | AU2009243065B2 (en) |
BR (1) | BRPI0911847B8 (en) |
CA (1) | CA2723011A1 (en) |
CL (1) | CL2009001025A1 (en) |
DK (1) | DK2285411T3 (en) |
ES (1) | ES2605244T3 (en) |
HK (1) | HK1153146A1 (en) |
HU (1) | HUE031175T2 (en) |
MX (1) | MX2010011929A (en) |
MY (1) | MY164646A (en) |
PL (1) | PL2285411T3 (en) |
PT (1) | PT2285411T (en) |
RU (1) | RU2458692C2 (en) |
WO (1) | WO2009134947A1 (en) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8470366B2 (en) | 2010-02-18 | 2013-06-25 | Jatin Thakkar | Nicotine containing soft gelatin pastilles |
WO2015051308A1 (en) * | 2013-10-03 | 2015-04-09 | Altria Client Services Inc. | Lozenge |
US9180124B2 (en) | 2010-09-16 | 2015-11-10 | J. B. Chemicals And Pharmaceuticals Limited | Nicotine containing formulation |
US9351936B2 (en) | 2013-10-03 | 2016-05-31 | Altria Client Services Llc | Nicotine lozenge |
WO2017182084A1 (en) | 2016-04-21 | 2017-10-26 | Fertin Pharma A/S | Nicotine delivery product, related uses and oral dosage forms, and methods of production |
US9999243B2 (en) | 2013-10-03 | 2018-06-19 | Altria Client Services Llc | Exhausted tobacco lozenge |
US10105320B2 (en) | 2013-10-03 | 2018-10-23 | Altria Client Services | Soluble fiber lozenge |
US10244786B2 (en) | 2013-10-03 | 2019-04-02 | Altria Client Services Llc | Tobacco lozenge |
CN111447921A (en) * | 2017-12-08 | 2020-07-24 | 费尔廷制药公司 | Nicotine tablet |
US11241413B2 (en) | 2019-04-17 | 2022-02-08 | Nordiccan A/S | Cannabinoid lozenge formulation |
WO2022256384A1 (en) * | 2021-06-04 | 2022-12-08 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Dosage form for nicotine replacement therapy |
US11779045B2 (en) | 2013-10-03 | 2023-10-10 | Altria Client Services Llc | Dissolvable-chewable exhausted-tobacco tablet |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9474303B2 (en) | 2011-09-22 | 2016-10-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US20130078307A1 (en) | 2011-09-22 | 2013-03-28 | Niconovum Usa, Inc. | Nicotine-containing pharmaceutical composition |
US9084439B2 (en) | 2011-09-22 | 2015-07-21 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US9629392B2 (en) | 2011-09-22 | 2017-04-25 | R.J. Reynolds Tobacco Company | Translucent smokeless tobacco product |
US9763928B2 (en) | 2012-02-10 | 2017-09-19 | Niconovum Usa, Inc. | Multi-layer nicotine-containing pharmaceutical composition |
US9044035B2 (en) | 2012-04-17 | 2015-06-02 | R.J. Reynolds Tobacco Company | Remelted ingestible products |
AR096223A1 (en) * | 2013-05-10 | 2015-12-16 | Glaxosmithkline Llc | NICOTINE PILL FOR ORAL ADMINISTRATION |
US20170172995A1 (en) * | 2015-09-08 | 2017-06-22 | Venkateswara Rao Repaka | Pharmaceutical compositions of Nicotine and process for preparation thereof |
US20210345656A1 (en) * | 2017-12-08 | 2021-11-11 | Fertin Pharma A/S | High nicotine absorption |
BR112020011238A2 (en) * | 2017-12-08 | 2021-01-05 | Fertin Pharma A/S | FORMULATION OF SOLID ORAL NICOTIN TO RELIEVE DESIRE OF NICOTINE QUICK START, FORMULATION OF SOLID ORAL NICOTINE FOR USE IN ATTENUING NICOTIN DESIRE, METHOD OF ATTENUATING NICOTIN DESIRE AND ORAL PURSE |
EP3720497A1 (en) * | 2017-12-08 | 2020-10-14 | Fertin Pharma A/S | High nicotine concentration |
US11759419B2 (en) * | 2019-10-11 | 2023-09-19 | Fertin Pharma A/S | Compressed nicotine lozenge |
US11000540B1 (en) * | 2019-11-22 | 2021-05-11 | Al Siamon | Treatment for reducing adverse events including chemotherapy discomfort and other conditions |
WO2023053060A1 (en) * | 2021-09-30 | 2023-04-06 | Nicoventures Trading Limited | Oral gum composition |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4967773A (en) * | 1986-06-26 | 1990-11-06 | Shaw Alec S W | Nicotine containing lozenge |
US20030133982A1 (en) * | 2001-12-20 | 2003-07-17 | Heimlich John M. | Zero-order sustained release dosage forms and method of making same |
US20040191322A1 (en) * | 2002-12-20 | 2004-09-30 | Henri Hansson | Physically and chemically stable nicotine-containing particulate material |
US20070081949A1 (en) * | 2003-09-05 | 2007-04-12 | Arrow No. 7 Limited | Buccal drug delivery |
US20070269492A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
US20070298090A1 (en) * | 2001-04-20 | 2007-12-27 | Lavipharm Laboratories, Inc. | Intraoral delivery of nicotine for smoking cessation |
US20080286341A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered coated nicotine containing products |
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US4863737A (en) | 1985-05-01 | 1989-09-05 | University Of Utah | Compositions and methods of manufacture of compressed powder medicaments |
US5135753A (en) | 1991-03-12 | 1992-08-04 | Pharmetrix Corporation | Method and therapeutic system for smoking cessation |
US5549906A (en) | 1993-07-26 | 1996-08-27 | Pharmacia Ab | Nicotine lozenge and therapeutic method for smoking cessation |
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US20080287507A1 (en) | 2007-05-16 | 2008-11-20 | John Hedenstrom | Nicotine containing toiletry waters |
US20080286340A1 (en) | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
US20090004248A1 (en) | 2007-06-29 | 2009-01-01 | Frank Bunick | Dual portion dosage lozenge form |
US20090164008A1 (en) * | 2007-12-21 | 2009-06-25 | Xin Hong | Lens surface with combined diffractive, toric, and aspheric components |
PT2361081T (en) | 2008-10-14 | 2016-09-05 | Mcneil Ab | Multi portion intra-oral dosage form and use thereof |
EP2233134A1 (en) | 2009-03-27 | 2010-09-29 | McNeil AB | Multi-portion intra-oral dosage form with organoleptic properties |
US8784781B2 (en) | 2009-09-24 | 2014-07-22 | Mcneil-Ppc, Inc. | Manufacture of chewing gum product with radiofrequency |
-
2009
- 2009-04-29 CL CL2009001025A patent/CL2009001025A1/en unknown
- 2009-04-29 AR ARP090101535 patent/AR071420A1/en not_active Application Discontinuation
- 2009-04-30 DK DK09739749.1T patent/DK2285411T3/en active
- 2009-04-30 PL PL09739749T patent/PL2285411T3/en unknown
- 2009-04-30 ES ES09739749.1T patent/ES2605244T3/en active Active
- 2009-04-30 EP EP09739749.1A patent/EP2285411B1/en active Active
- 2009-04-30 MY MYPI2010005122A patent/MY164646A/en unknown
- 2009-04-30 US US12/990,049 patent/US8501164B2/en active Active
- 2009-04-30 BR BRPI0911847A patent/BRPI0911847B8/en active IP Right Grant
- 2009-04-30 RU RU2010149050/15A patent/RU2458692C2/en active
- 2009-04-30 WO PCT/US2009/042190 patent/WO2009134947A1/en active Application Filing
- 2009-04-30 HU HUE09739749A patent/HUE031175T2/en unknown
- 2009-04-30 CN CN200980125040.6A patent/CN102076362B/en active Active
- 2009-04-30 MX MX2010011929A patent/MX2010011929A/en active IP Right Grant
- 2009-04-30 JP JP2011507628A patent/JP5893405B2/en active Active
- 2009-04-30 PT PT97397491T patent/PT2285411T/en unknown
- 2009-04-30 CA CA 2723011 patent/CA2723011A1/en not_active Abandoned
- 2009-04-30 AU AU2009243065A patent/AU2009243065B2/en active Active
-
2011
- 2011-07-15 HK HK11107381.9A patent/HK1153146A1/en unknown
-
2013
- 2013-06-26 US US13/927,163 patent/US8940772B2/en active Active
-
2014
- 2014-12-17 US US14/572,953 patent/US20150105431A1/en not_active Abandoned
-
2015
- 2015-07-27 JP JP2015147991A patent/JP6159761B2/en active Active
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4967773A (en) * | 1986-06-26 | 1990-11-06 | Shaw Alec S W | Nicotine containing lozenge |
US20070298090A1 (en) * | 2001-04-20 | 2007-12-27 | Lavipharm Laboratories, Inc. | Intraoral delivery of nicotine for smoking cessation |
US20030133982A1 (en) * | 2001-12-20 | 2003-07-17 | Heimlich John M. | Zero-order sustained release dosage forms and method of making same |
US20040191322A1 (en) * | 2002-12-20 | 2004-09-30 | Henri Hansson | Physically and chemically stable nicotine-containing particulate material |
US20070081949A1 (en) * | 2003-09-05 | 2007-04-12 | Arrow No. 7 Limited | Buccal drug delivery |
US20070269492A1 (en) * | 2006-05-16 | 2007-11-22 | Per Steen | New product and use and manufacture thereof |
US20080286341A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered coated nicotine containing products |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8470366B2 (en) | 2010-02-18 | 2013-06-25 | Jatin Thakkar | Nicotine containing soft gelatin pastilles |
US9180124B2 (en) | 2010-09-16 | 2015-11-10 | J. B. Chemicals And Pharmaceuticals Limited | Nicotine containing formulation |
US11116758B2 (en) | 2013-10-03 | 2021-09-14 | Altria Client Services Llc | Nicotine lozenge |
US10702516B2 (en) | 2013-10-03 | 2020-07-07 | Altria Client Services Llc | Nicotine lozenge |
US11554099B2 (en) | 2013-10-03 | 2023-01-17 | Altria Client Services Llc | Soluble fiber lozenge |
US9943511B2 (en) | 2013-10-03 | 2018-04-17 | Altria Client Services Llc | Nicotine lozenge |
US9999243B2 (en) | 2013-10-03 | 2018-06-19 | Altria Client Services Llc | Exhausted tobacco lozenge |
US10105320B2 (en) | 2013-10-03 | 2018-10-23 | Altria Client Services | Soluble fiber lozenge |
US10244786B2 (en) | 2013-10-03 | 2019-04-02 | Altria Client Services Llc | Tobacco lozenge |
US9351936B2 (en) | 2013-10-03 | 2016-05-31 | Altria Client Services Llc | Nicotine lozenge |
WO2015051308A1 (en) * | 2013-10-03 | 2015-04-09 | Altria Client Services Inc. | Lozenge |
US10925309B2 (en) | 2013-10-03 | 2021-02-23 | Altria Client Sendees LLC | Tobacco lozenge |
US11723904B2 (en) | 2013-10-03 | 2023-08-15 | Altria Client Services Llc | Nicotine lozenge |
US11849753B2 (en) | 2013-10-03 | 2023-12-26 | Altria Client Services Llc | Tobacco lozenge |
US11779045B2 (en) | 2013-10-03 | 2023-10-10 | Altria Client Services Llc | Dissolvable-chewable exhausted-tobacco tablet |
US11311623B2 (en) | 2016-04-21 | 2022-04-26 | Fertin Pharma A/S | Nicotine delivery product, related uses and oral dosage forms, and methods of production |
WO2017182084A1 (en) | 2016-04-21 | 2017-10-26 | Fertin Pharma A/S | Nicotine delivery product, related uses and oral dosage forms, and methods of production |
CN111447921A (en) * | 2017-12-08 | 2020-07-24 | 费尔廷制药公司 | Nicotine tablet |
US11738016B2 (en) | 2017-12-08 | 2023-08-29 | Fertin Pharma A/S | Nicotine tablet |
CN111447921B (en) * | 2017-12-08 | 2023-10-13 | 费尔廷制药公司 | Nicotine tablet |
US11241413B2 (en) | 2019-04-17 | 2022-02-08 | Nordiccan A/S | Cannabinoid lozenge formulation |
WO2022256384A1 (en) * | 2021-06-04 | 2022-12-08 | Glaxosmithkline Consumer Healthcare Holdings (Us) Llc | Dosage form for nicotine replacement therapy |
Also Published As
Publication number | Publication date |
---|---|
BRPI0911847B8 (en) | 2021-05-25 |
HUE031175T2 (en) | 2017-06-28 |
US20110110880A1 (en) | 2011-05-12 |
EP2285411B1 (en) | 2016-09-21 |
US20130289079A1 (en) | 2013-10-31 |
BRPI0911847A2 (en) | 2015-10-06 |
PT2285411T (en) | 2016-11-25 |
PL2285411T3 (en) | 2017-07-31 |
HK1153146A1 (en) | 2012-03-23 |
MY164646A (en) | 2018-01-30 |
DK2285411T3 (en) | 2017-01-02 |
BRPI0911847B1 (en) | 2021-04-13 |
CL2009001025A1 (en) | 2010-09-24 |
AU2009243065B2 (en) | 2013-05-23 |
US8501164B2 (en) | 2013-08-06 |
JP5893405B2 (en) | 2016-03-23 |
CA2723011A1 (en) | 2009-11-05 |
EP2285411A4 (en) | 2011-05-18 |
ES2605244T3 (en) | 2017-03-13 |
JP2011519862A (en) | 2011-07-14 |
AR071420A1 (en) | 2010-06-16 |
MX2010011929A (en) | 2010-11-30 |
US8940772B2 (en) | 2015-01-27 |
JP6159761B2 (en) | 2017-07-05 |
BRPI0911847A8 (en) | 2018-03-06 |
RU2458692C2 (en) | 2012-08-20 |
EP2285411A1 (en) | 2011-02-23 |
CN102076362B (en) | 2015-01-21 |
US20150105431A1 (en) | 2015-04-16 |
RU2010149050A (en) | 2012-06-10 |
JP2015232012A (en) | 2015-12-24 |
AU2009243065A1 (en) | 2009-11-05 |
CN102076362A (en) | 2011-05-25 |
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