WO2009134938A1 - Indoline anti-cancer agents - Google Patents
Indoline anti-cancer agents Download PDFInfo
- Publication number
- WO2009134938A1 WO2009134938A1 PCT/US2009/042181 US2009042181W WO2009134938A1 WO 2009134938 A1 WO2009134938 A1 WO 2009134938A1 US 2009042181 W US2009042181 W US 2009042181W WO 2009134938 A1 WO2009134938 A1 WO 2009134938A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- alkyl
- aryl
- arylalkyl
- alkenyl
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title claims description 7
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title description 7
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 17
- 230000002062 proliferating effect Effects 0.000 claims abstract description 13
- 201000011510 cancer Diseases 0.000 claims abstract description 10
- 150000001875 compounds Chemical class 0.000 claims description 173
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 77
- -1 Cl- C12 heteroalkyl Chemical group 0.000 claims description 70
- 125000000217 alkyl group Chemical group 0.000 claims description 58
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 50
- 125000005842 heteroatom Chemical group 0.000 claims description 49
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 46
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 43
- 229910052760 oxygen Inorganic materials 0.000 claims description 42
- 229910052717 sulfur Inorganic materials 0.000 claims description 42
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 40
- 125000003118 aryl group Chemical group 0.000 claims description 39
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 35
- 125000000623 heterocyclic group Chemical group 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 35
- 238000000034 method Methods 0.000 claims description 34
- 125000005843 halogen group Chemical group 0.000 claims description 31
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 29
- 229910052799 carbon Inorganic materials 0.000 claims description 25
- 125000002252 acyl group Chemical group 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 22
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims description 21
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims description 20
- 125000004429 atom Chemical group 0.000 claims description 20
- 229910052739 hydrogen Inorganic materials 0.000 claims description 19
- 229910052757 nitrogen Inorganic materials 0.000 claims description 18
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 13
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 12
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 12
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 12
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 11
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 10
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 10
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 10
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 9
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical class C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 claims description 8
- 150000002916 oxazoles Chemical class 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 125000006823 (C1-C6) acyl group Chemical group 0.000 claims description 6
- IMSODMZESSGVBE-UHFFFAOYSA-N 2-Oxazoline Chemical class C1CN=CO1 IMSODMZESSGVBE-UHFFFAOYSA-N 0.000 claims description 6
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical class C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims description 6
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical class C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 claims description 5
- 125000001624 naphthyl group Chemical group 0.000 claims description 5
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 5
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 5
- 125000002098 pyridazinyl group Chemical group 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 5
- VLLMWSRANPNYQX-UHFFFAOYSA-N thiadiazole Chemical class C1=CSN=N1.C1=CSN=N1 VLLMWSRANPNYQX-UHFFFAOYSA-N 0.000 claims description 5
- 150000003852 triazoles Chemical class 0.000 claims description 5
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical group C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims description 4
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical class C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 claims description 4
- WEQPBCSPRXFQQS-UHFFFAOYSA-N 4,5-dihydro-1,2-oxazole Chemical class C1CC=NO1 WEQPBCSPRXFQQS-UHFFFAOYSA-N 0.000 claims description 4
- GUUULVAMQJLDSY-UHFFFAOYSA-N 4,5-dihydro-1,2-thiazole Chemical class C1CC=NS1 GUUULVAMQJLDSY-UHFFFAOYSA-N 0.000 claims description 4
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims description 4
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical group C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 claims description 4
- MTNDZQHUAFNZQY-UHFFFAOYSA-N imidazoline Chemical class C1CN=CN1 MTNDZQHUAFNZQY-UHFFFAOYSA-N 0.000 claims description 4
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical class C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims description 4
- CTAPFRYPJLPFDF-UHFFFAOYSA-N isoxazole Chemical class C=1C=NOC=1 CTAPFRYPJLPFDF-UHFFFAOYSA-N 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- DNXIASIHZYFFRO-UHFFFAOYSA-N pyrazoline Chemical class C1CN=NC1 DNXIASIHZYFFRO-UHFFFAOYSA-N 0.000 claims description 4
- ZVJHJDDKYZXRJI-UHFFFAOYSA-N pyrroline Chemical class C1CC=NC1 ZVJHJDDKYZXRJI-UHFFFAOYSA-N 0.000 claims description 4
- CBDKQYKMCICBOF-UHFFFAOYSA-N thiazoline Chemical class C1CN=CS1 CBDKQYKMCICBOF-UHFFFAOYSA-N 0.000 claims description 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 3
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims description 3
- BCMCBBGGLRIHSE-UHFFFAOYSA-N 1,3-benzoxazole Chemical group C1=CC=C2OC=NC2=C1 BCMCBBGGLRIHSE-UHFFFAOYSA-N 0.000 claims description 2
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 239000012634 fragment Substances 0.000 claims description 2
- 150000003536 tetrazoles Chemical class 0.000 claims description 2
- 125000003827 glycol group Chemical group 0.000 claims 1
- 238000011282 treatment Methods 0.000 abstract description 15
- 230000002927 anti-mitotic effect Effects 0.000 abstract 1
- 125000003387 indolinyl group Chemical class N1(CCC2=CC=CC=C12)* 0.000 abstract 1
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 152
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 150
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 112
- 238000006243 chemical reaction Methods 0.000 description 100
- 239000000203 mixture Substances 0.000 description 90
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 81
- 235000019439 ethyl acetate Nutrition 0.000 description 76
- 239000011541 reaction mixture Substances 0.000 description 74
- 239000000243 solution Substances 0.000 description 70
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 66
- 239000007858 starting material Substances 0.000 description 60
- 239000007832 Na2SO4 Substances 0.000 description 53
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 53
- 229910052938 sodium sulfate Inorganic materials 0.000 description 53
- 239000000047 product Substances 0.000 description 51
- 229920006395 saturated elastomer Polymers 0.000 description 48
- 239000012043 crude product Substances 0.000 description 43
- 239000007787 solid Substances 0.000 description 43
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 41
- 239000000463 material Substances 0.000 description 40
- 125000001424 substituent group Chemical group 0.000 description 39
- 239000012044 organic layer Substances 0.000 description 36
- 210000004027 cell Anatomy 0.000 description 35
- 150000001412 amines Chemical class 0.000 description 34
- 239000012267 brine Substances 0.000 description 34
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 34
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 33
- 238000003756 stirring Methods 0.000 description 33
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 28
- 238000000746 purification Methods 0.000 description 22
- 239000011780 sodium chloride Substances 0.000 description 22
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 20
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 20
- 125000003342 alkenyl group Chemical group 0.000 description 20
- 238000005859 coupling reaction Methods 0.000 description 20
- 125000000304 alkynyl group Chemical group 0.000 description 19
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 19
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 18
- 239000011550 stock solution Substances 0.000 description 18
- 230000008878 coupling Effects 0.000 description 17
- 238000010168 coupling process Methods 0.000 description 17
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-diisopropylethylamine Substances CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 16
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 description 16
- NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 16
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 15
- 239000008346 aqueous phase Substances 0.000 description 15
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 14
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 14
- 239000012074 organic phase Substances 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 125000002947 alkylene group Chemical group 0.000 description 13
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 238000002347 injection Methods 0.000 description 12
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 12
- 0 *C(Cc(cc12)ccc1OC1N(*)c3ccccc3C21c1c(*)nc(C(*)N2*)[o]1)C2=O Chemical compound *C(Cc(cc12)ccc1OC1N(*)c3ccccc3C21c1c(*)nc(C(*)N2*)[o]1)C2=O 0.000 description 11
- 239000000706 filtrate Substances 0.000 description 11
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 11
- 239000000543 intermediate Substances 0.000 description 11
- 150000001408 amides Chemical group 0.000 description 10
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 description 10
- 125000004432 carbon atom Chemical group C* 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 10
- 238000009472 formulation Methods 0.000 description 10
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 10
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 10
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 9
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- 230000004663 cell proliferation Effects 0.000 description 9
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- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 8
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- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 6
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- VZSRBBMJRBPUNF-UHFFFAOYSA-N 2-(2,3-dihydro-1H-inden-2-ylamino)-N-[3-oxo-3-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propyl]pyrimidine-5-carboxamide Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C(=O)NCCC(N1CC2=C(CC1)NN=N2)=O VZSRBBMJRBPUNF-UHFFFAOYSA-N 0.000 description 3
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- 238000000844 transformation Methods 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 description 1
- 125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
- FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 1
- 229910000404 tripotassium phosphate Inorganic materials 0.000 description 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
- 229960003048 vinblastine Drugs 0.000 description 1
- JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 1
- 229960004528 vincristine Drugs 0.000 description 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
Definitions
- the invention relates to indoline compounds of formula (I), and to salts, pharmaceutical compositions, and conjugates thereof, which are useful as antiproliferative agents.
- Diazonamide A is a mitotic spindle-disrupting agent first isolated from the marine organism Diazona angulata, having the structure:
- the invention is also directed towards pharmaceutical compositions comprising a compound of formula (I) and/or a salt or conjugate thereof, to modified forms of such compounds conjugated to stabilizing or targeting agents, and to methods of treating or ameliorating cell proliferative diseases using these compounds and formulations.
- the invention provides a compound of formula (I):
- R 1 is H, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 heteroalkyl, C2-C8 heteroalkenyl, C2-C8 heteroalkynyl, C6-C12 aryl, C7-C14 arylalkyl, C5-C12 heteroaryl, or C6-C14 heteroarylalkyl, each of which may be optionally substituted;
- R 2 is H, or C1-C8 alkyl, C1-C8 heteroalkyl, C7-C14 arylalkyl, C6-C14 heteroarylalkyl, each of which may be optionally substituted; or
- R 1 and R 2 may be taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member;
- R 4 is H, or C1-C4 alkyl
- R 5 is H, or C1-C8 alkyl, C2-C12 alkenyl, C3-C8 cycloalkyl, C4-C12 cycloalkylalkyl, C2-C12 alkynyl, C6-C12 aryl, C7-C14 arylalkyl, C5-C12 heteroaryl, C6- C14 heteroarylalkyl, alkylsulfonyl, or arylsulfonyl, or a heteroform of one of these, each of which may be optionally substituted; or
- R 4 and R 5 may be taken together with nitrogen to form an optionally substituted 3- to 8- membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member;
- R 6 is H, or C1-C8 alkyl, C1-C8 heteroalkyl, C7-C14 arylalkyl, C6-C14 heteroarylalkyl, C1-C6 acyl, C6-C12 aroyl, alkylsulfonyl, or arylsulfonyl, each of which may be optionally substituted;
- R 7 is H, halo, optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl, optionally substituted C5-C12 heterocyclyl, -CN, -COR 8 , -COOR 8 , or - C(O)NR 9 2 ;
- R 8 is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; and each R 9 is independently H, or Cl -C 12 alkyl, Cl -C 12 heteroalkyl, C2-C12 alkenyl, C2-C12 heteroalkenyl, C3-C8 cycloalkyl, C3-C8 heterocyclyl, C4-C12 cycloalkylalkyl, C4-C12 heterocyclylalkyl, C6-C12 aryl, C5-C12 heteroaryl, C7-C14 arylalkyl, or C6-C14 heteroarylalkyl, each of which may be optionally substituted; or two R 9 on the same N can cyclize to form an optionally substituted 3- to 8-membered azacyclic ring, optionally containing an
- the invention provides a compound of formula (II):
- X is O, S, NR" or (CH 2 ) n , where n is 0-2, and R" is H, C1-C8 alkyl, C5- C8 aryl, C6-C12 arylalkyl, C1-C6 acyl, C6-C12 aroyl, alkylsulfonyl, or arylsulfonyl; and R 4 , R 5 , R 6 , R 7 , Y, Y', m and m' are defined as for formula (I). [0011] In another aspect, the invention provides a compound of formula (V) or formula (VI):
- R 1 , R 2 , R 7 , Y, and m are defined as for formula (I);
- Z is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl; and each of R 10 , R 1Oa and R I0b is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; or
- R IOa and R IOb may be taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocyclyl ring, which may be optionally substituted.
- the invention provides a pharmaceutical composition comprising at least one compound of any of formulae (I), (II), (III), (IV), (V) or (VI) and a pharmaceutically acceptable excipient.
- the invention provides a method for treating or ameliorating a cell proliferative disorder, comprising administering to a subject in need thereof a therapeutically effective amount of at least one compound of formulae (I), (II), (III), (IV), (V) or (VI) or a salt, conjugate, or pharmaceutical composition thereof.
- the amount administered is sufficient to inhibit cell proliferation.
- the amount is sufficient to slow tumor growth or reduce tumor size.
- the compound of formulae (I)-(VI) is used in combination with another chemotherapeutic agent or approach.
- the cells are in a cell line, such as a cancer cell line (e.g., a cell line derived from breast, prostate, pancreatic, lung, or hematopoietic cancers, etc.).
- a cancer cell line e.g., a cell line derived from breast, prostate, pancreatic, lung, or hematopoietic cancers, etc.
- the cells are in a tissue, an in some such embodiments, the tissue can be in a subject.
- the cells are in a tumor, and sometimes are in a tumor in a subject.
- kits for treating cancer in a subject in need of such treatment comprising: administering to the subject a therapeutically effective amount of a compound of formula (I)-(VI) or a salt or conjugate thereof, as described herein, in an amount that is effective to treat or ameliorate said cancer.
- the compound of formula (I)-(VI) is a compound in one of the Tables provided herein, or a pharmaceutically acceptable salt or conjugate of one of these compounds.
- the invention further provides methods for treating or ameliorating a condition related to aberrant cell proliferation.
- methods of treating or ameliorating a cell proliferative disorder in a subject comprising administering a compound of formula (I)-(VI) or a salt or conjugate thereof, as described herein, to a subject in need thereof in an amount effective to treat or ameliorate the condition.
- the subject may be a research animal (e.g., rodent, dog, cat, monkey), optionally containing a tumor such as a xenograft tumor (e.g., human tumor), for example, or may be a human.
- a research animal e.g., rodent, dog, cat, monkey
- a tumor such as a xenograft tumor (e.g., human tumor)
- a xenograft tumor e.g., human tumor
- Figure 1 shows data for compound of Example 73 in an HCTl 16 human colon carcinoma xenograft model in mice.
- Compound of Example 73 was administered at 20 mg/kg per dose. Injections were given at days 9, 1 1, 14, 16, 18 and 21 post tumor cell injection. At day 25, the tumor size for treated animals was 34.5% of control, and a maximum weight loss of 7.9% was observed.
- Figure 2 shows data for compound of Example 73 in a Miapaca pancreatic cancer xenograft model in mice. The compound of Example 73 was administered at 20 mg/kg per dose. Injections were given at days 6, 8, 11, 13, 15 and 18 post tumor cell injection.
- the term "subject” refers to a human or animal subject. In preferred embodiments, the subject is human.
- treat in reference to a particular disease or disorder include prevention of the disease or disorder, and/or lessening, improving, ameliorating, alleviating or removing the symptoms and/or pathology of the disease or disorder.
- the term "therapeutically effective amount” or “effective amount” is intended to mean that amount of a drug or pharmaceutical agent that will elicit a biological or medical response of a cell, tissue, system, animal or human that is being sought by a researcher, veterinarian, medical doctor or other clinician.
- the terms also can refer to reducing or stopping a cell proliferation rate (e.g., slowing or halting tumor growth) or reducing the number of proliferating cancer cells (e.g., removing part or all of a tumor).
- the rate or cell proliferation is reduced by 10%, 20%, 30%, 40%, 50%, 60%, or 70% or more.
- the number of proliferating cells is reduced by 10%, 20%, 30%, 40%, 50%, 60%, or 70% or more.
- alkyl straight- chain, branched-chain and cyclic monovalent hydrocarbyl radicals, and combinations of these, which contain only C and H when they are unsubstituted. Examples include methyl, ethyl, isopropyl, isobutyl, tert-butyl, cyclohexyl, cyclopentylethyl, 2-propenyl, 3-butynyl, and the like.
- the total number of carbon atoms in each such group is sometimes described herein, e.g., when the group can contain up to twelve carbon atoms it may be described as 1-12C or as Cl -C 12 or as Cl -12 or as C 1-12 .
- heteroatoms typically N, O and S
- the numbers describing the group though still written as e.g. C1-C6, represent the sum of the number of carbon atoms in the group plus the number of such heteroatoms that are included as replacements for carbon atoms in the ring or chain being described.
- the alkyl, alkenyl and alkynyl substituents of the invention contain 1-12C (alkyl) or 2-12C (alkenyl or alkynyl). Preferably they contain 1-8C (alkyl) or 2-8C (alkenyl or alkynyl). Sometimes they contain 1-4C (alkyl) or 2-4C (alkenyl or alkynyl).
- a single group can include more than one type of multiple bond, or more than one multiple bond; such groups are included within the definition of the term "alkenyl" when they contain at least one carbon-carbon double bond, and they are included within the term "alkynyl" when they contain at least one carbon-carbon triple bond.
- Heteroalkyl “heteroalkenyl”, and “heteroalkynyl” and the like are defined similarly to the corresponding hydrocarbyl (alkyl, alkenyl and alkynyl) groups, but the 'hetero' terms refer to groups that contain one or more heteroatoms selected from O, S and N and combinations thereof, within the backbone residue; thus at least one carbon atom of a corresponding alkyl, alkenyl, or alkynyl group is replaced by one of the specified heteroatoms to form a heteroalkyl, heteroalkenyl, or heteroalkynyl group.
- each heteroalkyl, heteroalkenyl and heteroalkynyl group contains only 1-2 heteroatoms as part of the skeleton of backbone of the heteroalkyl group, i.e., not including substituents that may be present.
- exemplary heteroalkyls include alkoxyls such as O-alkyl, alkyl ethers, secondary and tertiary alkyl amines, alkyl sulfides, and the like.
- heteroforms of alkyl, alkenyl and alkynyl groups are generally the same as for the corresponding hydrocarbyl groups, and the substituents that may be present on the heteroforms are the same as those described above for the hydrocarbyl groups.
- groups contain N the nitrogen atom may be present as NH or it may be substituted if the heteroalkyl or similar group is described as optionally substituted.
- groups contain S the sulfur atom may optionally be oxidized to SO or SO 2 unless otherwise indicated.
- alkyl as used herein includes cycloalkyl and cycloalkylalkyl groups
- cycloalkyl may be used herein to specifically describe a saturated or partially saturated, monocyclic or fused or spiro polycyclic, carbocycle that is connected via a ring carbon atom
- cycloalkylalkyl may be used to describe a carbocyclic non-aromatic group that is connected to the base molecule through an alkyl linker.
- heterocyclyl may be used to describe a non-aromatic cyclic group that contains at least one heteroatom as a ring member and that is connected to the molecule via a ring atom of the cyclic group, which may be C or N; and “heterocyclylalkyl” may be used to describe such a group that is connected to another molecule through an alkyl linker.
- the sizes and substituents that are suitable for the cycloalkyl, cycloalkylalkyl, heterocyclyl, and heterocyclylalkyl groups are the same as those described above for alkyl groups.
- cycloalkyl and heterocyclyl groups are C3-C8, and cycloalkylalkyl or heterocyclylalkyl groups are C4-C12.
- the size of a cycloalkylalkyl or heterocyclylalkyl group describes the total number of carbon atoms or of carbon atoms plus heteroatoms that replace carbon atoms of an alkyl, alkenyl, alkynyl, cycloalkyl, or cycloalkylalkyl portion. As used herein, these terms also include rings that contain a double bond or two, as long as the ring is not aromatic.
- Acyl and heteroacyl groups are bonded to any group or molecule to which they are attached through the open valence of the carbonyl carbon atom.
- C1-C8 acyl groups which include formyl, acetyl, trifluoroacetyl, pivaloyl, and benzoyl
- C2-C8 heteroacyl groups which include methoxyacetyl, ethoxycarbonyl, and 4- pyridinoyl.
- the hydrocarbyl groups, aryl groups, and heteroforms of such groups that comprise an acyl or heteroacyl group can be substituted with the substituents described herein as generally suitable substituents for each of the corresponding component of the acyl or heteroacyl group.
- Aromatic moiety or "aryl” moiety refers to a monocyclic or fused bicyclic moiety having the well-known characteristics of aromaticity; examples include phenyl and naphthyl.
- Carbocyclic aryl rings and ring systems typically 6-12 carbon ring atoms, and may include a saturated or partially unsaturated carbocyclic ring fused to an aromatic ring, e.g., a tetrahydronaphthalene, indane or indene ring system.
- heteroaryl refer to such monocyclic or fused bicyclic ring systems which contain as ring members one or more heteroatoms selected from O, S and N.
- heteroaromatic systems include monocyclic C5-C6 aromatic groups such as pyridyl, pyrimidyl, pyrazinyl, pyridazinyl, triazinyl, thienyl, furanyl, pyrrolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, imidazolyl, triazolyl, thiadiazolyl, oxadiazolyl, and tetrazolyl rings, and the fused bicyclic moieties formed by fusing one of these monocyclic groups with a phenyl ring or with any of the heteroaromatic monocyclic groups to form a C8-C10 bicyclic group such as indolyl, benzimidazolyl, indazolyl, benzotriazolyl, isoquino
- any monocyclic or fused ring bicyclic system which has the characteristics of aromaticity in terms of electron distribution throughout the ring system is included in this definition. It also includes bicyclic groups where at least one ring has the characteristics of aromaticity, even though it may be fused to a nonaromatic ring.
- the ring systems contain 5-12 ring member atoms.
- the monocyclic aryl and heteroaryl groups contain 5- 6 ring members, and the bicyclic aryl and heteroaryl groups contain 8-10 ring members.
- arylalkyl and “heteroarylalkyl” refer to aromatic and heteroaromatic ring systems which are bonded to their attachment point through a linking group such as an alkylene, including substituted or unsubstituted, saturated or unsaturated, cyclic or acyclic linkers.
- a linking group such as an alkylene, including substituted or unsubstituted, saturated or unsaturated, cyclic or acyclic linkers.
- the linker is C1-C8 alkyl or a heteroform thereof, preferably a C1-C4 alkyl.
- These linkers may also include a carbonyl group, thus making them able to provide substituents as an acyl or heteroacyl moieties.
- Arylalkyl groups as used herein are hydrocarbyl groups if they are unsubstituted, and are described by the total number of carbon atoms in the ring and alkylene or similar linker.
- a benzyl group is a C7-arylalkyl group
- phenylethyl is a C8-arylalkyl.
- an arylalkyl group includes one or two optionally substituted phenyl rings and a C1-C4 alkylene that is unsubstituted or is substituted with one or two C1-C4 alkyl groups or C1-C4 heteroalkyl groups, where the alkyl or heteroalkyl groups can optionally cyclize to form a ring such as cyclopropane, dioxolane, or oxacyclopentane, and wherein the alkyl or heteroalkyl groups may be optionally fluorinated.
- arylalkyl groups include optionally substituted benzyl, phenylethyl, diphenylmethyl, and triphenylmethyl groups.
- Optional substituents when present on the aryl ring of an arylalkyl group are the same as those described herein for an aryl ring.
- Arylalkyl groups typically contain from 7-20 atoms, preferably 7-14 atoms.
- Heteroarylalkyl refers to a moiety comprising an aryl group that is attached through a linking group, and differs from “arylalkyl” in that at least one ring atom of the aryl moiety or one atom in the linking group is a heteroatom selected from N, O and S.
- the heteroarylalkyl groups are described herein according to the total number of atoms in the ring and linker combined, and they include aryl groups linked through a heteroalkyl linker; heteroaryl groups linked through a hydrocarbyl linker such as an alkylene; and heteroaryl groups linked through a heteroalkyl linker.
- heteroaryl groups include pyridylmethyl, pyridylethyl, -O-benzyl, and the like.
- Heteroarylalkyl groups typically contain from 6-20 atoms, preferably 6-14 atoms.
- Alkylene refers to a divalent hydrocarbyl group; because it is divalent, it can link two other groups together. Typically it refers to -(CH 2 ) n - where n is 1-8 and preferably n is 1-4, though where specified, an alkylene can also be substituted by other groups, and can be of other lengths, and the open valences need not be at opposite ends of a chain. Thus -CH(Me)- and -C(Me) 2 - may also be referred to as alkylenes, as can a cyclic group such as cyclopropan-l,l-diyl.
- a three-atom linker that is an alkylene group refers to a divalent group in which the available valences for attachment to other groups are separated by three atoms such as -(CH 2 ) 3 -, i.e., the specified length represents the number of atoms linking the attachment points rather than the total number of atoms in the hydrocarbyl group: -C(Me) 2 - would thus be a one- atom linker, since the available valences are separated by only one atom.
- Heteroalkylene as used herein is defined similarly to the corresponding alkylene groups, but the 'hetero' terms refer to groups that contain one or more heteroatoms selected from O, S and N and combinations thereof, within the backbone residue; thus at least one carbon atom of a corresponding alkylene group is replaced by one of the specified heteroatoms to form a heteroalkylene group.
- Hetero form refers to a derivative of a group such as an alkyl, aryl, or acyl, wherein at least one carbon atom of the designated carbocyclic group has been replaced by a heteroatom selected from N, O and S.
- the heteroforms of alkyl, alkenyl, cycloalkyl, alkynyl, acyl, aryl, and arylalkyl are heteroalkyl, heteroalkenyl, heterocyclyl, heteroalkynyl, heteroacyl, heteroaryl, and heteroarylalkyl, respectively.
- heteroform of an aryl or arylalkyl moiety may contain one less "C" atom than the corresponding all carbon system, because the inclusion of a heteroatom permits aromaticity in 5-membered rings.
- the heteroform of C6-C12 aryl is C5-C12 heteroaryl
- the heteroform of C7-C20 arylalkyl is C6-C20 heteroarylalkyl.
- N, O or S atoms are ordinarily connected sequentially, except where an oxo group is attached to N or S to form a nitro or sulfonyl group, or in the case of certain heteroaromatic rings, such as triazine, triazole, tetrazole, oxadiazole, thiadiazole, and the like.
- Halo includes fluoro, chloro, bromo and iodo. Fluoro, chloro, and bromo are often preferred.
- amino refers to NH 2 , but where an amino is described as “substituted” or “optionally substituted”, the term includes NR 2 wherein each R is independently H, or is an alkyl, alkenyl, alkynyl, acyl, aryl, or arylalkyl group or a heteroform of one of these groups, as further defined herein, each of which may be optionally substituted with the substituents described herein as suitable for the corresponding type of group.
- the term also includes forms wherein the two R groups on one nitrogen atom (i.e., NR 2 ) are linked together to form a 3-8 membered monocyclic azacyclic ring or an 8-12 membered bicyclic fused azacyclic ring system, each of which may be saturated, unsaturated or aromatic and which may contain 1 -3 heteroatoms including the azacylic ring nitrogen atom independently selected from N, O and S as ring members (i.e., 0-2 heteroatoms selected from N, O and S in addition to the nitrogen atom of the azacyclic ring), and which may be optionally substituted with the substituents described as suitable for alkyl groups or, if NR 2 comprises an aromatic group, it may be optionally substituted with the substituents described as typical for aryl or heteroaryl groups.
- Amino groups may optionally be in a protected or unprotected form.
- suitable amine protecting groups may vary depending on the functionality present in the particular molecule and the nature of the amino group.
- Suitably protected amines may include, for example, amines protected as carbamates (e.g., tert-butoxycarbonyl (Boc), benzyloxycarbonyl (Cbz), fluorenylmethyloxy-carbonyl (Fmoc), allyloxycarbonyl (Alloc) or (trialkylsilyl)ethoxycarbonyl), carboxamides (e.g., formyl, acyl or trifluoroacetyl, benzoyl), sulfonamides, phthalimides, succinimides, Schiff s base derivatives, and the like. Also included are alkyl or allyl amines, as well as trialkylsilyl protected amines.
- alkylsulfonyl and arylsulfonyl refer to moieties of the form -SO 2 alkyl or -SO 2 aryl, where alkyl and aryl are defined as above.
- fluorinated Ci -4 alkyl, and optionally substituted phenyl groups are preferred for sulfonyl moieties.
- the phenyl groups of an arylsulfonyl moiety may be optionally substituted with one or more substituents suitable for an aryl ring; for example, they may be substituted by halo, methyl, nitro, alkoxy, amino, or the like.
- substituents suitable for an aryl ring for example, they may be substituted by halo, methyl, nitro, alkoxy, amino, or the like.
- Such sulfonyl moieties when present on oxygen form sulfonates.
- Such sulfonyl moieties form sulfonamides when present on nitrogen, and sulfones when present on carbon.
- Representative sulfonates include, e.g., - OSO 2 Me (mesylate), -OSO 2 CF 3 (triflate), -OSO 2 tolyl (tosylate), and the like.
- alkoxycarbonyl refers to a moiety of the form - COOR', where R' is C1-C8 alkyl, C2-C8 alkenyl, C5-C6 aryl, or C7-C14 arylalkyl, trialkylsilyl, or the like, each of which may be optionally substituted. When present on nitrogen, such alkoxycarbonyl moieties form carbamates, which are frequently used as nitrogen protecting groups.
- R' may be optionally halogenated C1-C4 alkyl (e.g., tert-butyl, methyl, ethyl, 2,2,2-trichloroethyl, l,l-dimethyl-2,2,2- trichloroethyl), allyl, optionally substituted benzyl, fluorenylmethyl, or trialkylsilyl (e.g., triisopropylsilyl, triethylsilyl, tert-butyldimethylsilyl).
- such moieties may also be referred to as carboxylate esters, carboalkoxy groups, or the like.
- R' is preferably a Ci -4 alkyl group.
- R' is methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl or t-butyl.
- substituted means that the specified group or moiety bears one or more non-hydrogen substituents.
- unsubstituted means that the specified group bears no such substituents.
- the group takes up two available valences, so the total number of substituents that may be included is reduced according to the number of available valences.
- Alkyl, alkenyl and alkynyl groups are often substituted to the extent that such substitution makes sense chemically.
- Alkyl, alkenyl and alkynyl groups can also be substituted by C1-C8 acyl, C2-C8 heteroacyl, C6-C12 aryl or C5-C12 heteroaryl, each of which can be substituted by the substituents that are appropriate for the particular group.
- optional substituents present on an alkyl, alkenyl or alkynyl group, or a heteroform of one of these include NRSO 2 R, NRCONR 2 , COOR, or CONR 2 , where R is defined as above; preferably, each R is independently H, optionally fluorinated C1-C4 alkyl, or is C6-C12 aryl, C5-C12 heteroaryl, C7-C20 arylalkyl, or C6-C20 heteroarylalkyl, each of which may be optionally substituted.
- Aryl, heteroaryl and heterocyclyl moieties may be substituted with a variety of substituents including optionally fluorinated C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 acyl, and heteroforms of these, C6-C12 aryl, C5-C12 for heteroaryl, C6-20 arylalkyl (C5-20 for heteroarylalkyl), each of which can itself be further substituted; other substituents for aryl and heteroaryl moieties include halo, OH, OR, CH 2 OH, CH 2 OR, CH 2 NR 2 , NR 2 , SR, SOR, SO 2 R, SO 2 NR 2 , NRSO 2 R, NRCONR 2 , NRCOOR, NRCOR, CN, COOR, CONR 2 , 00CR, C(O)R, and NO 2 , wherein each R is independently H, optionally fluorinated C1
- substituent groups on an aryl or heteroaryl group may of course be further substituted with the groups described herein as suitable for each type of group that comprises the substituent.
- Preferred substituents when present on an aryl, heteroaryl and heterocyclyl moieties include halo, OH, OR, CH 2 OH, CH 2 OR, CH 2 NR 2 , SR, NR 2 , CN, COOR, CONR 2 , and NO 2 , where R is defined as above, or optionally substituted C6-C12 aryl or C5-C12 heteroaryl ring.
- substituents may be on either the alkyl or heteroalkyl portion or on the aryl or heteroaryl portion of the group.
- the substituents optionally present on the alkyl or heteroalkyl portion are the same as those described above for alkyl groups generally; the substituents optionally present on the aryl or heteroaryl portion are the same as those described above for aryl groups generally.
- the carbon atom bearing the substituent R 1 in formulae (I), (II), (III), (V), (VI), or the corresponding atom in formula (IV), has the (S)- configuration.
- the present invention provides novel indoline analogs of formula (I), which are useful for the treatment or amelioration of proliferative disorders, in particular cancer.
- R 1 is H, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C5-C6 aryl, C6-C12 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted.
- R 1 is an optionally substituted C1-C4 alkyl; in some such embodiments, R 1 is isopropyl.
- R 2 is H, or C1-C8 alkyl, C1-C8 heteroalkyl, Cl- C 14 arylalkyl, C6-C14 heteroarylalkyl, each of which may be optionally substituted.
- R 2 is H or methyl.
- R 2 is H.
- R 1 and R 2 are taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member.
- R 1 and R 2 are taken together to form an optionally substituted 5- to 7-membered azacyclic ring containing no additional heteroatoms, i.e., an optionally substituted pyrrolidine, piperidine or homopiperidine ring.
- R 1 and R 2 are taken together to form an optionally substituted 5- to 7- membered azacyclic ring containing an additional heteroatom selected from N, O and S.
- R 1 and R 2 are taken together to form an optionally substituted morpholine, thiomorpholine, piperazine, or homopiperazine ring.
- R 4 is H, or Cl-C4 alkyl. In preferred embodiments, R 4 is H.
- R 5 is H, or C1-C8 alkyl, C2-C12 alkenyl, C3-C8 cycloalkyl, C4-C12 cycloalkylalkyl, C2-C12 alkynyl, C6-C12 aryl, C7- Cl 4 arylalkyl, alkylsulfonyl, or arylsulfonyl, or a heteroform of one of these, each of which may be optionally substituted.
- R 5 is an arylsulfonyl group, it is preferably not an o-nitrophenylsulfonyl group.
- the present invention specifically excludes the compound of formula
- the alkyl group comprising part of R 3 is substituted with at least one substituent selected from the group consisting of OH, OMe, OAc, NH 2 , NHMe, and NHAc.
- the alkyl group comprising part of R 3 is substituted with at least one substituent selected from the group consisting of OH, OMe, OAc, NH 2 , NHMe, CH 2 OH and NHAc.
- R 3 is a C 1 -C8 straight chain, branched, or cycloalkyl group, each of which is substituted on the carbon atom adjacent to the carbonyl group that is part of R 5 with OH, OMe, OAc, NH 2 , NHMe, CH 2 OH or NHAc.
- R 4 and R 5 may be taken together with nitrogen to form an optionally substituted 3- to 8- membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member.
- R 6 is H, or C1-C8 alkyl, C1-C8 heteroalkyl, Cl- C14 arylalkyl, C6-C14 heteroarylalkyl, optionally fluorinated C1-C6 acyl, C6-C12 aroyl, alkylsulfonyl, or arylsulfonyl, each of which may be optionally substituted.
- R is H.
- a substituent at R 6 may function as a protecting group. It will be understood that the methods described herein include an optional deprotection step to remove any protecting groups present on the molecule.
- R 7 is H, halo, optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl, optionally substituted C5-C12 heterocyclyl, - CN 5 -COR 8 , -COOR 8 , or -C(O)NR 9 2 , where R 8 is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted, and each R 9 is independently H, or Cl -C 12 alkyl, Cl -C 12 heteroalkyl, C2-C12 alkenyl, C2-C12 heteroalkenyl, C3-C8 cycloalkyl, C3-C8 heterocyclyl, C4-C12 cycloalkylalkyl, C4-C12 heterocyclylalkyl, C4-C12 heterocyclylal
- R 7 is CONR 9 2 , where each R 9 is defined as above.
- at least one R 9 is H, and the other R 9 is H or an optionally substituted C7-C14 arylalkyl or C6-C14 heteroarylalkyl group; preferably, the alkyl portion of such a group is a C1-C4 alkyl.
- at least one R 9 is an optionally substituted benzyl, diphenylmethyl, phenethyl, tetrahydronaphthyl, or a heteroarylalkyl group, such as an indolylalkyl or pyridinylalkyl.
- two R groups on the same nitrogen atom can cyclize to form an optionally substituted 3- to 8-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member.
- two R 9 groups on the same nitrogen atom are cyclized to form an optionally substituted pyrrolidine ring.
- R 7 is optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl ring, or optionally substituted C5-C12 heterocyclyl ring.
- R 7 is an optionally substituted phenyl, naphthyl, benzimidazole, benzoxazole, benzthiazole, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl ring.
- R 7 is an optionally substituted oxazole, oxazoline, thiazole, thiazoline, pyrazole, pyrazoline, imidazole, imidazoline, pyrrole, pyrroline, isoxazole, isoxazoline, isothiazole, isothiazoline, oxadiazole, thiadiazole, triazole or tetrazole ring.
- Preferred substituents when present on an optionally substituted C6-C12 aryl, C5-C12 heteroaryl, or C5-C12 heterocyclyl ring at R 7 include halo, nitro, cyano, or optionally fluorinated C1-C4 alkyl, optionally fluorinated C1-C4 alkoxy, COOR 8' , CONR 9' 2 , C6-C12 aryl or C5-C12 heteroaryl, each of which may be optionally substituted; where R 8' is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; and each R 9' is independently H, or Cl -C 12 alkyl, Cl -C 12 heteroalkyl, C2-C12 alkenyl, C2-C12 heteroalkenyl, C3-C8
- R 7 is an optionally substituted oxazole or thiazole ring.
- R 7 is an oxazole ring substituted with an optionally substituted C6-C12 aryl or C5-C12 heteroaryl ring.
- R 7 is an oxazole ring substituted with one or more alkyl, halo, carboxylic acid, ester or amide substituents.
- m is an integer from 0-4, and m' is an integer from 0-3. In certain embodiments, m is 0, 1, or 2, and m' is 0 or 1. In frequent embodiments, m' is 0.
- each Y and Y' is independently C1-C8 alkyl, C2- C8 alkenyl, C2-C8 alkynyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted, or is halo, OH, or C1-C4 alkoxy.
- R 1 , R 2 , R 3 , R 6 , R 7 , Y, Y', m and m' are as defined for formula (I).
- R is H, m' is 0, and m is 0 or 1.
- R 1 is C1-C4 alkyl.
- R 2 is H or methyl; preferably, R 2 is H.
- R 3 is C1-C4 alkyl, C3-C6 cycloalkyl, C4-C8 cycloalkylalkyl, or C6-C8 arylalkyl, each of which may be optionally substituted.
- R 3 is C1-C8 alkyl, C2-C10 alkenyl, C3-C8 cycloalkyl, C4-C9 cycloalkylalkyl, or C7-C14 arylalkyl, each of which may be optionally substituted.
- the alkyl group comprising part of R 3 is substituted with at least one substituent selected from the group consisting of OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl.
- R 3 is substituted with at least one substituent selected from the group consisting of OH, OMe, OAc, NH 2 , NHMe, CH 2 OH and NHAc.
- R 3 is a group of the form -CH(Z)R 10 , where Z is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl, and R 10 is C1-C6 alkyl, C2- C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7- C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted.
- Z is OH, OMe, OAc, CH 2 OH, SH, SMe, SAc, NH 2 , NHMe, NMe 2 , NHAc. Sometimes, Z is OH, OMe, OAc, NH 2 , NHMe, or NHAc. In certain preferred embodiments, Z is OH.
- R 3 is a group of the form -C(Z)R 1Oa R 1Ob , where Z is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl, and each of R 1Oa andR 1Ob is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; or R 1Oa and R 1Ob may be taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocycl
- Z is OH, OMe, OAc, CH 2 OH, SH, SMe, SAc, NH 2 , NHMe, NMe 2 , NHAc. Sometimes, Z is OH, OMe, OAc, NH 2 , NHMe, or NHAc. In certain preferred embodiments, Z is OH.
- R 1 , R 2 , R 3 , R 6 , R 7 , Y, and m are as defined for formula (I).
- R 6 is H, m' is 0, and m is 0 or 1.
- R 1 is C1-C4 alkyl.
- R 2 is H or methyl; preferably, R 2 is H.
- Embodiments described for formulae (I) or (II) are also suitable for compounds of formula (III), (IV), (V) or (VI).
- R 1 is a C1-C8 alkyl, sometimes a C1-C4 alkyl, each of which may be optionally substituted. In certain preferred embodiments, R 1 is isopropyl.
- R 2 is H or methyl; in certain preferred embodiments, R 2 is H. In other embodiments, R 1 and R are taken together to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O and S.
- R 3 is Cl -C 12 alkyl, Cl -C 12 heteroalkyl, C2- C12 alkenyl, C2-C12 heteroalkenyl, C3-C8 cycloalkyl, C3-C8 heterocyclyl, C4-C12 cycloalkylalkyl, C4-C12 heterocyclylalkyl, C6-C12 aryl, C5-C12 heteroaryl, C7-C14 arylalkyl, or C6-C14 heteroarylalkyl, each of which may be optionally substituted.
- R 3 is C1-C8 alkyl, C2-C10 alkenyl, C3-C8 cycloalkyl, C4-C9 cycloalkylalkyl, or C7-C14 arylalkyl, each of which may be optionally substituted.
- the alkyl group comprising part of R 3 is substituted with at least one substituent selected from the group consisting of OH, OMe, OAc, NH 2 , NHMe, CH 2 OH and NHAc.
- R 3 is a group of the form -CH(Z)R 10 , where Z is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl, and R 10 is C1-C6 alkyl, C2- C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, Cl- C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted.
- Z is OH, OMe, OAc, CH 2 OH, SH, SMe, SAc, NH 2 , NHMe, NMe 2 , NHAc.
- Z is OH.
- Z is OH, OMe, OAc, NH 2 , NHMe, or NHAc
- R 10 is C1-C4 alkyl, C3-C6 cycloalkyl, or optionally substituted phenyl.
- R 3 is a group of the form -C(Z)R 1Oa R 1Ob , where Z is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl, and each of R 1Oa andR 1Ob is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; or R 1Oa and R 1 may be taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocyclyl
- Z is OH, OMe, OAc, CH 2 OH, SH, SMe, SAc, NH 2 , NHMe, NMe 2 , NHAc. Sometimes, Z is OH, OMe, OAc, NH 2 , NHMe, or NHAc. In certain preferred embodiments, Z is OH.
- references made to compounds and embodiments of formula (III) include compounds of formulae (III-A), (III-B), (UI-C), and (III-D).
- R 7 is -C(O)NR 9 2; where R 9 is defined as for formula (I).
- R 7 is an optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl or optionally substituted C5-12 heterocyclyl ring.
- R 7 is an optionally substituted phenyl, naphthyl, benzimidazole, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl ring.
- R 7 is an optionally substituted oxazole, oxazoline, thiazole, thiazoline, pyrazole, pyrazoline, imidazole, imidazoline, pyrrole, pyrroline, isoxazole, isoxazoline, isothiazole, isothiazoline, oxadiazole, thiadiazole, triazole or tetrazole ring.
- R 4 , R 5 , R 6 , R 7 , Y, Y', m, and m' are defined as for formula (I).
- 5 X is O, S, NR" or (CH 2 ) n , where n is 0-2, and R" is H, C1-C8 alkyl, C5-C8 aryl, C6-C12 arylalkyl, C1-C6 acyl, C6-C12 aroyl, alkylsulfonyl, or arylsulfonyl.
- X is (CH 2 ) n , where n is 0-2.
- R 4 is H or methyl
- R 5 is C(O)R 3 , where R is defined as for formula (I).
- R is a group of the form -CH(Z)R 10 or -C(Z)R 1Oa R 10b , where Z is OH, OMe, OAc, NH 2 , NHMe, or NHAc, and each of R 10 , R 1Oa and R 1Ob is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; or R !Oa and R 1Ob may be taken together with the carbon to which they are attached to form a C3-C8
- the invention provides a compound of formula (V) or formula (VI):
- R 1 is H, or C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C8 heteroalkyl, C2-C8 heteroalkenyl, C2-C8 heteroalkynyl, C6-C12 aryl, C7-C14 arylalkyl, C5-C12 heteroaryl, or C6-C14 heteroarylalkyl, each of which may be optionally substituted;
- R 2 is H, or C1-C8 alkyl, C1-C8 heteroalkyl, C7-C14 arylalkyl, C6-C14 heteroarylalkyl, each of which may be optionally substituted; or
- R 1 and R 2 may be taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member;
- R 7 is H, halo, optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl, optionally substituted C5-C12 heterocyclyl, -CN, -COR 8 , -COOR 8 , or - C(O)NR 9 2 ;
- R 8 is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; and each R 9 is independently H, or Cl -C 12 alkyl, Cl -C 12 heteroalkyl, C2-C12 alkenyl, C2-C12 heteroalkenyl, C3-C8 cycloalkyl, C3-C8 heterocyclyl, C4-C12 cycloalkylalkyl, C4-C12 heterocyclylalkyl, C6-C12 aryl, C5-C12 heteroaryl, C7-C14 arylalkyl, or C6-C14 heteroarylalkyl, each of which may be optionally substituted; or two R 9 on the same N can cyclize to form an optionally substituted 3- to 8-membered azacyclic ring, optionally containing an
- Z is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl; and each of R 10 , R 1Oa and R 1Ob is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; or
- R 1Oa and R 1Ob may be taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocyclyl ring, which may be optionally substituted.
- R 1 is optionally substituted C1-C4 alkyl, C2-C4 alkenyl or C2-C4 alkynyl; in some such embodiments, R 1 is isopropyl.
- R 2 is H or C1-C4 alkyl; sometimes, R 2 is H or methyl. In certain preferred embodiments, R 2 is H.
- R 1 and R 2 are taken together with the atoms to which they are attached to form an optionally substituted 5- to 7-membered azacyclic ring, optionally containing an additional heteroatom selected from N, O, and S as a ring member.
- R 1 and R 2 are taken together to form an optionally substituted 5- to 7-membered azacyclic ring containing no additional heteroatoms, i.e., an optionally substituted pyrrolidine, piperidine or homopiperidine ring.
- R 1 and R 2 are taken together to form an optionally substituted 5- to 7-membered azacyclic ring containing an additional heteroatom selected from N, O and S. In some such embodiments, R 1 and R 2 are taken together to form an optionally substituted morpholine, thiomorpholine, piperazine, or homopiperazine ring.
- m is an integer from 0-4. In preferred embodiments, m is 0 or 1.
- each Y is independently is halo, OH, or C1-C4 alkoxy, or is C1-C8 alkyl, C2-C8 alkenyl, C2- C8 alkynyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted.
- m is 1 and Y is halo, preferably chloro. In other embodiments, m is 0.
- Z is OH, OR, CH 2 OR, SR, and NR 2 , where each R is independently H, optionally fluorinated C1-C4 alkyl, or optionally fluorinated C1-C4 acyl.
- Z is OH, OMe, OAc, CH 2 OH, SH, SMe, SAc, NH 2 , NHMe, NMe 2 , NHAc.
- Z is OH.
- each of R 1Oa and R 10b is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted.
- R 1Oa and R 1Ob are the same. In other embodiments, R 1Oa and R 1Ob are different. In certain preferred embodiments, each of R 1Oa and R 10b comprises at least two carbon atoms.
- each of R 1Oa and R 1Ob may independently be ethyl, propyl, isopropyl, allyl, propargyl, n-butyl, s-butyl, isobutyl, t- butyl, pentyl, cyclopropyl, and the like; in some such embodiments, R 1Oa and R 1Ob are the same. In a preferred embodiment, each of R 1Oa and R 1Ob is ethyl.
- R 1Oa and R 1Ob are taken together with the carbon to which they are attached to form a C3-C8 cycloalkyl or a C3-C8 heterocyclyl ring, which may be optionally substituted.
- R 1Oa and R 1Ob may be taken together to form an optionally substituted cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, tetrahydrofuran, tetrahydropyran, tetrahydrothiofuran, tetrahydrothiopyran, pyrrolidine, or piperidine ring, and the like.
- each of R 1Oa and R 1 b are taken together to form a cyclohexyl or a cyclopentyl ring.
- the ring formed by R 1Oa and R 1Ob may be fused to a substituted or unsubstituted phenyl ring to provide, for example, and indenyl or tetrahydronaphthyl ring system.
- R 10 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C3-C8 cycloalkylalkyl, C6-C12 aryl, C7-C20 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted.
- R 7 is H, halo, optionally substituted C6-C12 aryl, optionally substituted C5-C12 heteroaryl, optionally substituted C5-C12 heterocyclyl, -CN, -COR 8 , -COOR 8 , or -C(O)NR 9 2 .
- R 7 is -C(O)NR 9 2; where R 9 is defined as for formula (I).
- R 7 comprises an optionally substituted aromatic, heteroaromatic or heterocyclic ring.
- R 7 is an optionally substituted phenyl, naphthyl, benzimidazole, pyridinyl, pyrimidinyl, pyrazinyl or pyridazinyl ring.
- R 7 is an optionally substituted oxazole, oxazoline, thiazole, thiazoline, pyrazole, pyrazoline, imidazole, imidazoline, pyrrole, pyrroline, isoxazole, isoxazoline, isothiazole, isothiazoline, oxadiazole, thiadiazole, triazole or tetrazole ring.
- R 1 , R 2 , Z, Y 5 m, R 10 , R 1Oa and R 10b are defined as for formula (V) and formula (VI); and each of R 11 and R 12 is independently H, halo, nitro, cyano, or optionally fluorinated C1-C4 alkyl, optionally fluorinated C1-C4 alkoxy, COOR 8' , CONR 9' 2 , C6-C12 aryl or C5-C12 heteroaryl, each of which may be optionally substituted; where R 8' is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; and each R 9' is independently H, or Cl -C 12 alkyl, Cl -C 12 heteroal
- each R 1 ' and R i2 is independently H, halo, C1-C4 alkyl, COOR 8' , or CONR 9' 2 ; or is C6-C12 aryl or C5-C12 heteroaryl, each of which may be optionally substituted.
- R 7 is an optionally substituted heterocyclic or heteroaromatic ring of the formula:
- Q is O, S or NR 13 , where R 13 is H or C1-C4 alkyl; each R 14 is independently halo, nitro, cyano, or optionally fluorinated C1-C4 alkyl, optionally fluorinated C1-C4 alkoxy, COOR 8' , CONR 9' 2 , C6-C12 aryl or C5-C12 heteroaryl, each of which may be optionally substituted; where R 8' is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; and each R 9' is independently H, or Cl -C 12 alkyl, Cl -C 12 heteroalkyl, C2-C12 alkenyl, C2-C12 heteroalkenyl, C3-C8 cycloalkyl, C3-C8 heterocyclyl, C3
- R 7 is wherein each R 11 and R 12 is independently H, halo, nitro, cyano, or optionally fluorinated C1-C4 alkyl, optionally fluorinated C1-C4 alkoxy, COOR 8' , CONR 9 2 , C6- C12 aryl or C5-C12 heteroaryl, each of which may be optionally substituted; where R 8' is H, or C1-C8 alkyl, C2-C8 alkenyl, C6-C12 aryl, or C7-C14 arylalkyl, or a heteroform of one of these, each of which may be optionally substituted; and each R 9' is independently H, or Cl -C 12 alkyl, Cl -C 12 heteroalkyl, C2-C12 alkenyl, C2-C12 heteroalkenyl, C3-C8 cycloalkyl, C3-C8 heterocyclyl, C
- each R 11 and R 12 is independently H, halo, C1-C4 alkyl, COOR 8' , or CONR 9> 2 ; or is C6-C12 aryl or C5-C12 heteroaryl, each of which may be optionally substituted.
- racemic mixtures of single diastereomers such as the ones described, diastereomers having an diastereomeric excess (d.e.) of greater than 90% or greater than about 95%, and enantiomers having an enantiomeric excess (e.e.) of greater than 90% or greater than about 95%.
- the compounds can exist in some cases as either cis or trans isomers; the invention includes each isomer individually as well as mixtures of isomers.
- this invention relates to the use of all such tautomers and mixtures thereof.
- Compounds of formulae (I), (II), (III), (IV), (V) and (VI) can be supplied in free base form, or can be supplied as a pharmaceutically acceptable salt, or as a mixture of the free base form and the corresponding salt.
- the compounds of the invention may be isolated as salts where an ionizable group such as a basic amine or a carboxylic acid is present.
- the invention includes the salts of these compounds that have pharmaceutically acceptable counterions.
- Such salts are well known in the art, and include, for example, salts of acidic groups formed by reaction with organic or inorganic bases, and salts of basic groups formed by reaction with organic or inorganic acids, as long as the counterions introduced by the reaction are acceptable for pharmaceutical uses.
- inorganic bases with alkali metal hydroxides (e.g., sodium hydroxide, potassium hydroxide, etc.), alkaline earth metal hydroxides (e.g., of calcium, magnesium, etc.), and hydroxides of aluminum, ammonium, etc.
- alkali metal hydroxides e.g., sodium hydroxide, potassium hydroxide, etc.
- alkaline earth metal hydroxides e.g., of calcium, magnesium, etc.
- organic bases that could be used include trimethylamine, triethylamine, pyridine, picoline, ethanolamine, diethanolamine, triethanolamine, dicyclohexylamine, N,N'-dibenzylethylenediamine, etc.
- Suitable salts include those of inorganic acids such as hydrochlorides, hydrobromides, sulfates, hydrosulfates, and the like, or organic acid addition salts.
- inorganic acids that could be used include hydrochloric acid, hydrobromic acid, nitric acid, sulfuric acid, phosphoric acid, etc.
- organic acids include formic acid, oxalic acid, acetic acid, tartaric acid, methanesulfonic acid, benzenesulfonic acid, malic acid, methanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, etc.
- salts with basic amino acids such as arginine, lysine, ornithine, etc.
- salts with acidic amino acids such as aspartic acid, glutamic acid, etc.
- compounds of formulae (I), (II), (III), (IV), (V) and (VI) may be coupled to moieties such as targeting agents.
- targeting agents are antibodies or immunologically active fragments thereof, including single-chain antibody forms directed against tumor antigens or against receptors or integrins associated with tumors, peptidomimetics directed against these moieties, and the like.
- compounds of formulae (I), (II), (III), (IV), (V) and (VI) may be coupled to an excipient such as polyethylene glycol for altering pharmacokinetics.
- the selected PEG may be of any convenient molecular weight, and may be linear or branched, and may be optionally conjugated through a linker. The average molecular weight of PEG will preferably range from about 2 kiloDalton (kDa) to about 100 kDa, more preferably from about 5 kDa to about 40 kDa.
- Compounds of formulae (I), (II), (III), (IV), (V) and (VI) are useful in treating or ameliorating cell proliferative diseases.
- the compounds and methods described herein are useful for the treatment or amelioration of tumors and malignancies associated with breast, ovary, lung (SCLC and NSCLC), colon, rectum, prostate, testes, skin (e.g., melanoma, basal cell carcinoma, and squamous cell carcinoma), pancreas, liver, kidney, brain (e.g., glioma, meningioma, schwannomas, and medulloblastomas), and the blood and hematopoietic system, including, e.g., leukemia, non-Hodgkins lymphoma, and multiple myeloma.
- cell proliferation may be reduced, and/or cell death, such as apoptosis or apoptotic cell death, may be induced.
- the cell proliferative disorder may be a tumor or non-tumor cancer in a human or animal subject.
- the compounds and methods provided herein for reducing cell proliferation and/or inducing cell death may be used alone, or in conjunction with or in combination with surgical, radiation, chemotherapeutic, immunotherapy, and bone marrow and/or stem cell transplantation methods, or with other palliative agents, such as compounds that aid in nutrition or general health, anti-emetic agents, and the like.
- the compounds of the present invention are administered in combination with a chemotherapeutic agent, and used to reduce cell proliferation, induce cell death, and/or treat or ameliorate a cell proliferative disorder.
- the compounds described herein are also useful against certain drug resistant tumors and cancer cell lines, in particular against cancers that are resistant to TAXOL® and/or vinca alkaloid anti-cancer agents.
- an additional chemotherapeutic drug is administered, it is typically one known to have cytostatic, cytotoxic or antineoplastic activity.
- agents include, without limitation, antimetabolites (e.g., cytarabine, fludaragine, 5-fiuoro-2'- deoxyuridine, gemcitabine, hydroxyurea, methotrexate); DNA active agents (e.g., bleomycin, chlorambucil, cisplatin, cyclophosphamide); intercalating agents (e.g., adriamycin and mitoxantrone); protein synthesis inhibitors (e.g., L-asparaginase, cycloheximide, puromycin); topoisomerase type I inhibitors (e.g., camptothecin, topotecan or irinotecan); topoisomerase type II inhibitors (e.g.
- microtubule inhibitors e.g., taxanes, such as paclitaxel and docetaxel, colcemid, colchicines, or vinca alkaloids, such as vinblastine and vincristine
- kinase inhibitors e.g. flavopiridol, staurosporin and hydroxystaurosporine
- drugs that affect Hsp90 e.g.
- the additional cancer therapeutic agent is TRAIL, a TRAIL receptor antibody, TNF- ⁇ or TNF- ⁇ .
- the additional drugs for co-administration with the compounds of the invention affects Hsp90 (heat-shock protein 90).
- Suitable Hsp90 inhibitors include ansamycin derivatives such as geldanomycin and geldanomycin derivatives including 17-(allylamino)-17-desmethoxygeldanamycin (17- AAG), its dihydro derivative, 17-AAGH 2 , and 17-amino derivatives of geldanamycin such as ⁇ -dimethylaminoethylamino- ⁇ -demethoxy-geldanamycin (17-DMAG), 11- oxogeldanamycin, and 5,6-dihydrogeldanamycin, which are disclosed in U.S. Pat. Nos. 4,261,989; 5,387,584; and 5,932,566, each of which is incorporated herein by reference.
- Hsp90 inhibitors include radicicol and oximes and other analogs thereof, disclosed in Soga, et al., Curr. Cancer Drug Targets, 3, 359-69 (2003), and in Yamamoto, et al., Angew. Chem., 42, 1280-84 (2003); and in Moulin, et al., J. Amer. Chem. Soc. vol 127, 6999-7004 (2005); purine derivatives such as PU3, PU24FCI and PUH64 (see Chiosis et al., ACS Chem. Biol. Vol. 1(5), 279-284 (2006) and those disclosed in PCT Application No.
- Antibodies or antibody fragments that selectively bind to Hsp90 may also be administered as drugs to cause inhibition of Hsp90, and can be used in combination with the compounds of the invention.
- the two agents may be co-administered, or they may be administered separately where their administration is timed so the two agents act concurrently or sequentially.
- compositions used in the methods described herein include at least one compound of the invention, and can optionally include one or more additional cytotoxic or cytostatic therapeutic such as, but not limited to, those disclosed above.
- methods of the invention include methods wherein a subject diagnosed as in need of treatment for cancer is treated with at least one compound or composition of the invention, and is simultaneously or concurrently treated with one or more of the additional therapeutic agents described above.
- formulations useful in the invention include standard formulations such as those set forth in Remington's Pharmaceutical Sciences, latest edition, Mack Publishing Co., Easton, PA, incorporated herein by reference. Such formulations include those designed for oral delivery, slow release, topical administration, parenteral administration, or any other suitable route as determined by an attending physician or veterinarian. Thus administration may be systemic or local. Suitable vehicles or excipients include liposomes, micelles, nanoparticles, polymeric matrices, buffers, and the full range of formulations known to practitioners.
- Systemic formulations include those designed for injection (e.g., intramuscular, intravenous or subcutaneous injection) and those prepared for transdermal, transmucosal, or oral administration.
- the formulation will generally include a diluent as well as, in some cases, adjuvants, buffers, preservatives and the like.
- the compounds can be administered also in liposomal compositions or as microemulsions.
- Injection methods are sometimes appropriate routes for administration of the compounds for systemic treatments and sometimes also for localized treatments. These include methods for intravenous, intramuscular, subcutaneous, and other methods for internal delivery that bypass the mucosal and dermal barriers to deliver the composition directly into the subject's living tissues.
- formulations can be prepared in conventional forms as liquid solutions or suspensions or as solid forms suitable for solution or suspension in liquid prior to injection or as emulsions.
- Suitable excipients include, for example, water, saline, dextrose, glycerol and the like.
- Such compositions may also contain amounts of nontoxic auxiliary substances such as wetting or emulsifying agents, pH buffering agents and the like, such as, for example, sodium acetate, sorbitan monolaurate, and so forth.
- compositions can be utilized in such controlled-release delivery systems where appropriate.
- Systemic administration may also include relatively noninvasive methods such as the use of suppositories, transdermal patches, transmucosal delivery and intranasal administration.
- Oral administration is also suitable for compounds of the invention. Suitable forms include syrups, capsules, tablets, and the like as in understood in the art.
- compositions of the invention may be administered transmucosally using technology and formulation methods that are known in the art.
- the compounds described herein, which may be used in a suitable hydrated form, and/or the pharmaceutical compositions of the present invention, are formulated into pharmaceutically-acceptable dosage forms by conventional methods known to those of skill in the art.
- compositions of the present invention may be varied so as to obtain an amount of the active ingredient which is effective to achieve the desired therapeutic response for a particular patient, composition, and mode of administration, without being toxic to the patient.
- the selected dosage level will depend upon a variety of factors including the activity of the particular compound of the present invention employed, or the ester, salt or amide thereof, the route of administration, the time of administration, the rate of excretion or metabolism of the particular compound being employed, the rate and extent of absorption, the duration of the treatment, other drugs, compounds and/or materials used in combination with the particular compound employed, the age, sex, weight, condition, general health and prior medical history of the patient being treated, and like factors well known in the medical arts.
- the dosage of a compound of the invention is typically 10-2400 mg per administration.
- dosage levels are highly dependent on the nature of the condition, the condition of the patient, the judgment of the practitioner, and the frequency and mode of administration. Selection of a dosage of such compounds is within the skill of an ordinary artisan, and may be accomplished by starting at a relatively low dosage and increasing the dosage until an acceptable effect is achieved.
- Frequency of administration of the compounds of the invention can also be readily determined by one skilled in the art using well known techniques.
- the patient may be administered a low dosage of a compound or composition of the invention at a low frequency such as once per day or less often; and the dosage and/or frequency of administration may be systematically increased until a desired effect is achieved in the patient.
- Indolines of formula (I) have been prepared through a novel and efficient multi-step process, as shown in Scheme 1.
- a key step in the process involves the electrochemical oxidative cyclization of a phenolic intermediate to provide an indoline compound of formula (I), which may be further functionalized as exemplified by the compounds described herein.
- the oxidative cyclization was described in U.S. Application Serial No. 12/134,984, filed 6 June 2008, and published as US 2009/0005572, the contents of which are incorporated herein by reference in their entirety.
- Compounds of formula (II), (III), (IV), (V) and (VI) are prepared analogously.
- dipeptide starting materials were prepared under standard conditions known in the art, for example, by coupling an N-hydroxysuccinimide ester or another activated ester of a protected amino acid with serine. It will be understood by one of skill in the art that a wide variety of suitable conditions may be utilized to form the dipeptide starting materials, including the extensive body of literature describing synthesis of peptides and peptide mimetics.
- Suitable activating reagents include, for example, carboxylic acid anhydrides, mixed anhydrides, or acyl halides (e.g., acetic anhydride, trifluoroacetic anhydride, acetyl chloride, oxalyl chloride), sulfonic acid anhydrides or halides (e.g., methanesulfonic anhydride, trifluoromethanesulfonic anhydride, methanesulfonyl chloride), mineral acid halides (e.g., thionyl chloride, or phosphoryl chloride), and the like.
- carboxylic acid anhydrides e.g., mixed anhydrides, or acyl halides
- acetic anhydride trifluoroacetic anhydride, acetyl chloride, oxalyl chloride
- sulfonic acid anhydrides or halides e.g., methanesulfonic anhydride, triflu
- the activating agent was acetic anhydride, and the reaction was conducted in acetic acid as a protic solvent.
- the dipeptide and an optionally substituted indole were reacted with acetic anhydride in acetic acid at about 80 0 C, to provide the desired compound.
- R 5 is a sulfonyl (i.e., -SO 2 R or -SO 2 Ar) or an alkyl, alkenyl, alkynyl, arylalkyl, or a heteroform of one of these groups.
- R 5 is a sulfonyl (i.e., -SO 2 R or -SO 2 Ar) or an alkyl, alkenyl, alkynyl, arylalkyl, or a heteroform of one of these groups.
- Other transformations to install a substituent at R 5 for example, carbamoylation or urea formation, are also envisioned.
- One of skill in the art will understand that the order of these steps could be reversed, depending on the nature of the functional groups to be installed, and the protecting groups utilized.
- Scheme 1 provides a general synthetic route useful for the preparation of macrocyclic indoline compounds of formula (I).
- Those skilled in the art will appreciate that certain reaction conditions can be varied without altering the essence of the present invention.
- coupling reactions can be accomplished with a variety of activated esters, such as by way of example only N-hydroxybenzotriazole ester, perfluorophenyl ester, N-hydroxyphthalimide esters, activated esters generated by the reaction of the carboxylic acid with a carbodiimide, and other activated esters conventionally used for acylation of an amine to form amide bonds.
- Glacial acetic acid 25 mL was added to the Cbz derivative synthesized in Step D above (9.99 g, 19.0 mmol) in a 500-mL round bottom flask fitted with a mechanical stirrer. The suspension was stirred at 25 0 C and 33% HBr in acetic acid (50 mL) was added in one portion. The mixture became homogeneous and then a precipitate formed in 5-10 min. After 1 h, MTBE (235 mL) was added and stirring was continued at 25 0 C for another 1 h 20 min. The mixture was filtered and the precipitate was washed with MTBE (150 mL). The cream-colored powder was dried under vacuum to a weight of 8.91 g (99% yield). MS: m/z - 392.0 (M+l).
- An electrochemical cell was assembled using a polyethylene cylinder (15 cm diameter x 30 cm height) and a custom rack (polypropylene and nylon) which supported 48 vertical graphite rods (6.15 mm diameter x 30 cm length).
- the rods were arranged in a pattern of three concentric rings with 12 and 24 anodes in the inner and outer rings, respectively.
- the intermediate ring contained 12 cathodes, separated from adjacent anodes by approximately 7 mm. Electrodes were immersed to a depth of 24 cm.
- the phenolic material synthesized in Step F above (20.00 g, 29.0 mmol) and Et 4 NBF 4 (70.00 g, 322 mmol) were dissolved in DMF (4000 mL), and.
- KOH (-86%, 1.68 g, 26 mmol) was added in 10 mL of water. The solution was stirred vigorously by two 4-bladed turbines (50 mm diameter, blades at 45°, approx. 680 rpm) on a single shaft. The electrochemical reaction was carried out at a potential of 1.5-1.6 volts. Additional phenolic starting material (20.00 g, 20.00 g, 20.00 g, and 7.94 g) was added as a solid, along with KOH (-86%, 1.60 g, 1.63 g, 1.53 g, and 0.65 g) in water (5.0 mL, 5.0 mL, 5.0 mL, and 2.0 mL) on days 3, 5, 8, and 10, respectively.
- Example 8 The products of Examples 8 and 9 were prepared by coupling the amine from Example 3 with (i?)-tetrahydro-2-furoic acid and (S)-2-hydroxyisocaproic acid, respectively, under the conditions used for Example 7.
- Example 10 the product was prepared by reaction of 3,4,5-trimethoxybenzoyl chloride with the amine from Example 3.
- Example 13-30 were prepared using conditions similar to those described in Steps A-C of Example 11.
- the carboxylic acid synthesized in Example 2 served as the starting material for Examples 13-30, and was used in coupling reactions with a series of amines.
- Example 31
- Step C The conditions for this reaction are similar to those used for Step B of Example 11.
- the compound synthesized in Step A above served as the starting material.
- the crude product was used directly in the next step without purification.
- Example 39-42 were prepared using conditions similar to those described in Steps A-C of Example 38.
- the carboxylic acid synthesized in Step G of Example 1 served as the starting material for Examples 39-42, with four different aromatic boronic acids used in Step A.
- Example 47-53 were prepared using coupling conditions similar to those used in Example 7.
- the amine synthesized in Step B of Example 46 served as the starting material. Coupling of this amine with a series of carboxylic acids produced the amide derivatives.
- the reaction mixture was cooled to 0 0 C followed by addition of a stock solution of EDC in DMF (2.65 mg, 0.0138, 1.5 eq.). The resulting reaction mixture was stirred at RT for 18 h. The reaction was monitored by LCMS. The reaction mixture was diluted with EtOAc (30 mL)/water (10 mL). The organic phase was separated and the aqueous phase was extracted by EtOAc (2x10 mL). The combined organic layers were washed by water (20 mL), 10% aqueous NaHSO 4 (20 mL), water (20 mL), saturated aqueous NaHCO 3 (20 mL), and brine (2 x 2OmL), and then dried over Na 2 SO 4 .
- the reaction mixture was cooled to 0 0 C followed by addition of a stock solution of EDC (1.4 mg, 0.0072, 1.5 eq.) in DMF (0.100 mL). The resulting reaction mixture was stirred at room temperature for 18 h. The reaction was monitored by LCMS. The reaction mixture was diluted with EtOAc (30 mL)/water (10 mL). The organic phase was separated and the aqueous phase was extracted by EtOAc (2x10 mL). The combined organic layers were washed by water (20 mL), 10% aqueous NaHSO 4 (20 mL), water (20 mL), saturated NaHCO 3 (20 mL), and brine (2 x 2OmL), and then dried over Na 2 SO 4 .
- the reaction was monitored by LCMS.
- the reaction mixture was diluted with EtOAc (60 mL)/water (20 mL).
- the organic phase was separated and the aqueous phase was extracted by EtOAc (2 x 20 mL).
- the combined organic layers were washed by water (20 mL), 10% aqueous NaHSO 4 (20 mL), water (20 mL), saturated NaHCO 3 (20 mL), and brine (2 x 2OmL), and then dried over Na 2 SO 4 .
- MS: m/z 788.1 (M+l).
- Step B of Example 11 The conditions for this reaction are similar to those used for Step B of Example 11.
- the oxazole synthesized in Step B above served as the starting material.
- the crude product was used directly in the next step without purification.
- Example 68-70 The compounds in Examples 68-70 were prepared using coupling conditions similar to those used in Example 7.
- the amine synthesized in Step C of Example 67 served as the starting material. Coupling of this amine with a series of carboxylic acids produced the amide derivatives.
- the resulting reaction mixture was stirred at RT for 18 h.
- the reaction was monitored by LCMS.
- the reaction mixture was diluted with EtOAc (30 mL)/water (10 mL).
- the organic phase was separated and the aqueous phase was extracted by EtOAc (2 x 10 mL).
- the combined organic layers were washed by water (20 mL), 10% aqueous NaHSO 4 (20 mL), water (20 mL), saturated NaHCO 3 (20 mL), and brine (2 x 2OmL), and then dried over Na 2 SO 4 . After concentration the crude product was used in next step without further purification.
- Triphenylphosphine (57 mg, 0.216 mmol, 10 eq.) and hexachloroethane (51 mg, 0.216 mmol, 10 eq.) were added to a dry 15-mL flask equipped with a thermometer, and a magnetic stir bar. Anhydrous CH 2 Cl 2 (2 mL) was added and the resulting solution was cooled to 10 0 C in ice-water bath under N 2 . Triethylamine (0.042 mL, 0.302 mmol, 14 eq.) was added slowly to the solution, followed by stirring for 10 min. at 10 0 C.
- the reaction mixture was cooled to 0 0 C followed by addition of a stock solution of EDC (2.0 mg, 0.0105, 2.0 eq.) in DMF (0.100 mL). The resulting reaction mixture was stirred at RT for 18 h. The reaction was monitored by LCMS. The reaction mixture was diluted with EtOAc (30 mL)/ water (10 mL). The organic phase was separated and the aqueous phase was extracted by EtOAc (2 x 10 mL). The combined organic layers were washed by water (20 mL), 10% aqueous NaHSO 4 (20 mL), water (20 mL), saturated NaHCO 3 (20 mL), and brine (2 x 2OmL), and then dried over Na 2 SO 4 .
- Step C The conditions for this reaction are similar to those used for Step B of Example 11.
- the material synthesized in Step A above served as the starting material.
- the crude product was used directly in the next step without further purification.
- iV,7V-Diisopropylethylamine (0.004 mL, 3 mg, 0.023 mmol) was added, followed by EDC (4.4 mg, 0.023 mmol) and the solution was stirred overnight at RT.
- the reaction mixture was then diluted into EtOAc (20 mL) and washed with 1 //aqueous HCl (10 mL), saturated aqueous NaHCO 3 (5 mL), and saturated aqueous NaCl (5 mL).
- the organic layer was dried (Na 2 SO 4 ), decanted, and evaporated.
- Example 2 The compound synthesized in Example 2 was coupled with (S)-2-amino-l- propanol using the same conditions described for Step A of Example 78. This yielded the amide derivative.
- Triphenylphosphine (13.48 g, 51.4 mmol, 10 eq.) and hexachloroethane (12.17 g, 51.4 mmol, 10 eq.) were added to a dry 1-L three-neck round-bottom flask equipped with a thermometer, an addition funnel and a magnetic stir bar. Anhydrous CH 2 Cl 2 (320 mL) was added and the resulting solution was cooled to 10 0 C in ice- water bath under N 2 . Triethylamine (10.03 mL, 71.96 mmol, 14 eq.) was added slowly to the solution, followed by stirring for 10 min. at 10 0 C.
- Cell viability assays were run using standard protocols known to those of skill in art. Cells were plated in 96 well plates at the density of 3,000-10,000 cells per well. Twenty four hours later, cells were treated with increasing concentration of test compounds (1 nM to 1 ⁇ M). After another 48 hour, cell survival was measured using CELL-TITER-GLO® reagent (Promega) following the protocol provided by the manufacture. The IC5 0 value was determined as the concentration of test compound that kills 50% of the cell population.
- Compound J A synthetic diazonamide analog (“Compound J”) was used as a reference compound.
- Compound J has the structure:
- Example 46 The compound of Example 46 was profiled in tumor cell lines derived from a variety of origins. Data are provided in Table 3.
- Example 73 The compound of Example 73 was tested in HCTl 16 human colon carcinoma xenograft and Miapaca pancreatic cancer xenograft tumor models in 5- to 6-week-old Harlan Athymic Nude-Foxnlnu mice.
- mice were randomized into treatment groups of five mice per group.
- Tumor volume in mm 3 is calculated by the formula:
- volume (mm 3 ) (length x width 2 )/2.
- Example 73 The compound of Example 73 was dissolved in cremophor/ethanol (1 :1) at 20 mg/mL as the stock solution and then diluted in saline to 2.5 mg/mL.
- the compound and the vehicle 6.25% cremophor/6.25% ethanol in saline) were administered intravenously in a total volume of 0.2 mL three times a week for total six treatments.
- Example 73 The activity of Example 73 at 20 mpk in HCT 116 colon carcinoma xenograft model is provided in Figure 1.
- Example 73 The activity of Example 73 at 20 mpk in Miapaca pancreatic cancer xenograft model is provided in Figure 2.
- Figure 2 The entirety of each patent, patent application, publication and document referenced herein hereby is incorporated by reference. Citation of the above patents, patent applications, publications and documents is not an admission that any of the foregoing is pertinent prior art, nor does it constitute any admission as to the contents or date of these publications or documents.
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Abstract
Description
Claims
Priority Applications (6)
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EP09739740.0A EP2268146B1 (en) | 2008-04-29 | 2009-04-29 | Indoline anti-cancer agents |
AU2009243056A AU2009243056B2 (en) | 2008-04-29 | 2009-04-29 | Indoline anti-cancer agents |
JP2011507624A JP5123429B2 (en) | 2008-04-29 | 2009-04-29 | Indoline anticancer agent |
CN200980115546.9A CN102014632B (en) | 2008-04-29 | 2009-04-29 | Indoline anti-cancer agents |
CA2720516A CA2720516C (en) | 2008-04-29 | 2009-04-29 | Indoline anti-cancer agents |
HK11101090.4A HK1147035A1 (en) | 2008-04-29 | 2011-02-01 | Indoline anti-cancer agents |
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Cited By (3)
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WO2008154441A1 (en) | 2007-06-07 | 2008-12-18 | Joyant Pharmaceuticals, Inc. | Methods for preparing diazonamides |
WO2012145255A2 (en) | 2011-04-22 | 2012-10-26 | Joyant Pharmaceuticals, Inc. | Diazonamide analogs |
EP3036226A1 (en) * | 2013-08-22 | 2016-06-29 | The General Hospital Corporation | Inhibitors of human 12/15-lipoxygenase |
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JP4406205B2 (en) | 2000-11-02 | 2010-01-27 | スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ | Small molecule composition for binding to HSP90 |
US7022720B2 (en) * | 2001-08-24 | 2006-04-04 | Board Of Regents, The University Of Texas System | Synthetic diazonamides as novel anti-mitotic agents |
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Cited By (14)
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WO2008154441A1 (en) | 2007-06-07 | 2008-12-18 | Joyant Pharmaceuticals, Inc. | Methods for preparing diazonamides |
EP2068904A1 (en) * | 2007-06-07 | 2009-06-17 | Joyant Pharmaceuticals, Inc. | Methods for preparing diazonamides |
EP2068904A4 (en) * | 2007-06-07 | 2011-08-10 | Joyant Pharmaceuticals Inc | Methods for preparing diazonamides |
JP2014512384A (en) * | 2011-04-22 | 2014-05-22 | ジョワイヤン ファーマスーティカルズ,インコーポレイテッド | Diazonamide analog |
WO2012145255A3 (en) * | 2011-04-22 | 2012-12-27 | Joyant Pharmaceuticals, Inc. | Diazonamide analogs |
US8592469B2 (en) | 2011-04-22 | 2013-11-26 | Joyant Pharmaceuticals, Inc. | Diazonamide analogs |
WO2012145255A2 (en) | 2011-04-22 | 2012-10-26 | Joyant Pharmaceuticals, Inc. | Diazonamide analogs |
US8846734B2 (en) | 2011-04-22 | 2014-09-30 | Joyant Pharmaceuticals, Inc. | Diazonamide analogs |
AU2012245702B2 (en) * | 2011-04-22 | 2016-09-29 | Joyant Pharmaceuticals, Inc. | Diazonamide analogs |
RU2608308C2 (en) * | 2011-04-22 | 2017-01-17 | Джоянт Фармасьютикалс, Инк. | Diazonium amide analogues |
KR101839642B1 (en) * | 2011-04-22 | 2018-03-16 | 조얀트 파마슈티컬스, 아이엔씨. | Diazonamide analogs |
EP3036226A1 (en) * | 2013-08-22 | 2016-06-29 | The General Hospital Corporation | Inhibitors of human 12/15-lipoxygenase |
EP3036226A4 (en) * | 2013-08-22 | 2017-04-05 | The General Hospital Corporation | Inhibitors of human 12/15-lipoxygenase |
US10287279B2 (en) | 2013-08-22 | 2019-05-14 | The Children's Hospital Corporation | Inhibitors of human 12/15-lipoxygenase |
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JP5123429B2 (en) | 2013-01-23 |
HK1147035A1 (en) | 2011-07-29 |
EP2268146B1 (en) | 2015-08-26 |
AU2009243056A1 (en) | 2009-11-05 |
US20120264763A1 (en) | 2012-10-18 |
EP2268146A1 (en) | 2011-01-05 |
CA2720516A1 (en) | 2009-11-05 |
CN102014632B (en) | 2014-05-28 |
US20100035946A1 (en) | 2010-02-11 |
EP2268146A4 (en) | 2012-05-02 |
US8334311B2 (en) | 2012-12-18 |
CN102014632A (en) | 2011-04-13 |
CA2720516C (en) | 2013-10-01 |
AU2009243056B2 (en) | 2015-05-14 |
US7989482B2 (en) | 2011-08-02 |
JP2011524855A (en) | 2011-09-08 |
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