WO2009133389A1 - Methods of preparing substituted heterocycles - Google Patents
Methods of preparing substituted heterocycles Download PDFInfo
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- WO2009133389A1 WO2009133389A1 PCT/GB2009/050424 GB2009050424W WO2009133389A1 WO 2009133389 A1 WO2009133389 A1 WO 2009133389A1 GB 2009050424 W GB2009050424 W GB 2009050424W WO 2009133389 A1 WO2009133389 A1 WO 2009133389A1
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- IAYGCINLNONXHY-LBPRGKRZSA-N NC(Nc1c(C(N[C@@H]2CNCCC2)=O)[s]c(-c2cccc(F)c2)c1)=O Chemical compound NC(Nc1c(C(N[C@@H]2CNCCC2)=O)[s]c(-c2cccc(F)c2)c1)=O IAYGCINLNONXHY-LBPRGKRZSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Definitions
- the present disclosure relates to methods of preparing substituted thiophenes, which are useful for the treatment and prevention of cancers. Also disclosed are substituted thiophenes made by the methods disclosed herein.
- Chemotherapy and radiation exposure are currently the major options for the treatment of cancer, but the utility of both these approaches is severely limited by drastic adverse effects on normal tissue, and the frequent development of tumor cell resistance. It is therefore highly desirable to improve the efficacy of such treatments in a way that does not increase the toxicity associated with them.
- One way to achieve this is by the use of specific sensitizing agents such as those described herein.
- the substituted thiophenes of the present invention have been shown to be potent inhibitors of the CHKl kinase (WO 2005/066163).
- CHKl CHKl kinase
- the presently disclosed substituted heterocycles possess the ability to prevent cell cycle arrest at the G2/M checkpoint in response to DNA damage.
- These compounds are accordingly useful for their anti-proliferative (such as anti-cancer) activity and are therefore useful in methods of treatment of the human or animal body.
- Such methods include treatment of disease states associated with cell cycle arrest and cell proliferation such as cancers (solid tumors and leukemias), fibroproliferative and differentiative disorders, psoriasis, rheumatoid arthritis, Kaposi's sarcoma, haemangioma, acute and chronic nephropathies, atheroma, atherosclerosis, arterial restenosis, autoimmune diseases, acute and chronic inflammation, bone diseases and ocular diseases with retinal vessel proliferation.
- cancers solid tumors and leukemias
- fibroproliferative and differentiative disorders psoriasis, rheumatoid arthritis, Kaposi's sarcoma, haemangioma, acute and chronic nephropathies, atheroma, atherosclerosis, arterial restenosis, autoimmune diseases, acute and chronic inflammation, bone diseases and ocular diseases with retinal vessel proliferation.
- the present invention provides methods of preparing substituted thiophenes that use no metal- catalyzed couplings or brominations, thus obviating the need for chromatography, which can effectively limit the scale at which a reaction is run. Recrystallization procedures have replaced the solvent exchange, which minimizes degradation of the final product. Overall yield has increased such that far less starting materials are required.
- Ri is an aryl ring optionally substituted with one or more R 4 groups selected from halogen, Ci_ 6 alkoxy, Ci_ 6 alkoxycarbonyl, Ci_ 6 alkyl, C 2 - 6 alkenyl, C 2 - 6 alkynyl, amido, amino, aryl, aryloxy, carboxy, cycloalkyl, heterocyclyl, and hydroxy;
- R 2 is -NHC(O)NHR 5 , where R 5 is selected from H, Ci_ 6 alkyl, Ci_ 6 alkoxycarbonyl, aryl, cycloalkyl, and heterocyclyl;
- R3 is -C(O)NR 6 Ry, where R 6 and R 7 are each independently selected from H, Ci_ 6 alkyl, cycloalkyl and a 5, 6, or 7- membered heterocyclyl ring containing at least one nitrogen atom, provided R 6 and R 7 are not both H; comprising
- reaction mixture refers to a solution or slurry comprising at least one product of a chemical reaction between reagents, as well as by-products, e.g., impurities (including compounds with undesired stereochemistries), solvents, and any remaining reagents, such as starting materials.
- the reaction mixture is a slurry, where a slurry can be a composition comprising at least one solid and at least one liquid (such as water, acid, or a solvent), e.g., a suspension or a dispersion of solids.
- an intermediate is not isolated from the reaction mixture prior to carrying out the next transformation.
- a reaction step can be performed in a large scale.
- "large scale” refers to the use of at least 1 gram of a starting material, intermediate or reagent, such as the use of at least 2 grams, at least 5 grams, at least 10 grams, at least
- the 2-thioacetamide compound has the following formula III:
- the 2-thioacetamide compound can be present in a reaction mixture slurry, which is reacted with the compound of formula II.
- the reaction of the 2-thioacetamide compound with the compound of formula II can take place in the presence of a nucleophilic base.
- the base can serve to form the 2-thioacetamide compound in situ by deacetylating a precursor thioacetyl intermediate.
- the base can be selected from sodium methoxide, sodium hydroxide, sodium or potassium ethoxide, sodium or potassium t-butoxide, and sodium t-amylate.
- the base can be sodium methoxide. The base may be added before or after the compound of formula II.
- the base may be present, for example, in about 1.1-3.5 equivalents, such as about 1.5 equivalents.
- the compound of formula II may be present in, for example, about 0.9 equivalents.
- the reaction can take place in any solvent deemed suitable by one of ordinary skill in the art.
- the solvent can be 2-methyltetrahydrofuran.
- the reaction can be carried out at about 0-40 0 C.
- the method further comprises purifying the resulting thiophene intermediate by crystallization.
- the crystallization can be performed at about 0-5 0 C from 1-3 days.
- the compound of formula II can be formed by treating acetophenone IV with a Vilsmeier reagent to give iminium species V.
- Variable R on iminium species V can be an alkyl group, such as a methyl group.
- the acetophenone can be added either before or after the formation of the Vilsmeier reagent.
- Suitable Vilsmeier reagents can be prepared from DMF and POCI 3 , DMF and oxalyl chloride, DMF and PCl 5 , DMF and thionyl chloride, and DMF, POCl 3 , and PCl 5 . In one embodiment, DMF and POCl 3 can be used.
- DMF can be the bulk solvent
- about 2 equivalents of DMF in toluene or acetonitrile can be used.
- a different dialkyl formamide HC(O)NR 2 can be used, including formamides where the R groups together form a cycle such as cycloalkyls and morpholine.
- Alternatives to the Cl " counterion of iminium V include perchlorate and PF 6 " salts.
- the iminium V can be treated with hydroxylamine hydrochloride, phosphate or sulfate to form an oxime VI, which further reacts to provide the compound of formula II.
- the hydroxylamine salt and iminium V can be added in either order.
- the oxime VI can be isolated prior to conversion to the compound of formula II.
- oxime VI can react in situ to yield the compound of formula II.
- purification of the compound of formula II by crystallization can be carried out on the same day as its formation.
- Ri is an aryl ring optionally substituted with one or more R 4 groups selected from halogen, d_ 6 alkoxy, Ci_ 6 alkoxycarbonyl, d_ 6 alkyl, C 2 - 6 alkenyl, C 2-6 alkynyl, amido, amino, aryl, aryloxy, carboxy, cycloalkyl, heterocyclyl, and hydroxy;
- R 2 is -NHC(O)NHR 5 , where R 5 is selected from H, Ci_ 6 alkyl, Ci_ 6 alkoxycarbonyl, aryl, cycloalkyl, and heterocyclyl;
- R 3 is -C(O)NR 6 Ry, where R 6 and R 7 are each independently selected from H, Ci_ 6 alkyl, cycloalkyl and a 5, 6, or 7- membered heterocyclyl ring containing at least one nitrogen atom, provided R 6 and R 7 are not both H; comprising
- a molar excess of haloacetyl halide is added to HNR 6 R 7 , such as about 1.5 equivalents.
- the haloacetyl halide can be chloroacetyl chloride or chloroacetyl bromide.
- a base can be added with the haloacetyl halide, such as pyridine, diisopropylamine, triethylamine, 2,6-lutidine, and N,N-dimethylaminopyridine.
- the base can be pyridine.
- the base may be added in molar excess of the HNR 6 R 7 , such as 1.2 equivalents.
- the haloacetamide intermediate is not isolated prior to addition of the thioacetic acid salt. In another embodiment, the haloacetamide intermediate is isolated prior to treatment with the thioacetic acid salt. In one embodiment, the haloacetamide intermediate can be ClCH 2 C(O)NReRy. In one embodiment, the thioacetic acid salt can be an alkaline earth salt, such as potassium thioacetate or tetramethylammonium thioacetate. The thioacetic acid salt can be added in molar excess of the haloacetamide intermediate, such as about 1.5 equivalents. The reactions can take place in any solvent deemed suitable by one of ordinary skill in the art.
- the addition of thioacetic acid salt can occur in a biphasic water/2 - methyltetrahydrofuran system.
- Anhydrous tetrahydrofuran or anhydrous 2- methyltetrahydrofuran can also be used.
- Ri is an aryl ring optionally substituted with one or more R 4 groups selected from halogen, Ci- ⁇ alkoxy, Ci_6alkoxycarbonyl, Ci- ⁇ alkyl, C2-6alkenyl, C 2- 6alkynyl, amido, amino, aryl, aryloxy, carboxy, cycloalkyl, heterocyclyl, and hydroxy;
- R 2 is -NHC(O)NHR 5 , where R 5 is selected from H, d_ 6 alkyl, d_ 6 alkoxycarbonyl, aryl, cycloalkyl, and heterocyclyl;
- R3 is -C(O)NR ⁇ R 7 , where Re and R 7 are each independently selected from H, Ci_6alkyl, cycloalkyl and a 5, 6, or 7- membered heterocyclyl ring containing at least one nitrogen atom, provided R 6 and R 7 are not both H; comprising
- the ureido intermediate is a compound of formula VIII
- a molar excess of isocyanate is added to the intermediate of formula IV, such as about up to about 2 equivalents.
- the isocyanate can be trichloroacetyl isocyanate.
- the solvent can be selected from tetrahydrofuran, acetonitrile and methyl tert-butyl ether, such as tetrahydrofuran.
- the ureido intermediate can be isolated prior to reacting with a base.
- the ureido intermediate can be in a reaction mixture slurry when the base is added.
- the base can be added in molar excess to the ureido intermediate, such as about 2.5 equivalents.
- the base may be selected from triethylamine, diisopropylethylamine, methylamine, and ethanol magnesium salt and methanol.
- the base can be triethylamine.
- the reaction can be performed for about 2.5 to about 4 hours. The reactions can take place in any solvent deemed suitable by one of ordinary skill in the art.
- the solvent can be chosen from tetrahydrofuran, acetonitrile, dichloromethane, toluene, benzene, diethyl ether, dioxane, hexane, and carbon tetrachloride.
- the solvent can be tetrahydrofuran.
- the resulting urea intermediate can be purified by crystallization through portionwise addition of water.
- formation of the compound of formula I comprises (a) reacting a thiophene intermediate of formula VII, or a pharmaceutically acceptable salt thereof,
- the one or more reagents may be selected from trimethylsilyl isocyanate followed by acidic workup; sodium, potassium, or silver cyanate; isocyanic acid; monochloroacetyl isocyanate followed by NaOMe; carbodiimide followed by urea; urea in refluxing pyridine; nitrourea; benzyl isocyanate followed by NaOH; benzyloxyisocyanate followed by hydrogenolysis; phosgene, ammonia, and benzene; thiourea, triethylamine, and methanol; chlorocarbonyl isocyanate followed by ammonia; ethyl chloroformate followed by ammonia; and silicon tetraisocyanate.
- the ureido intermediate bears an acid-labile protecting group such that reacting it with a base provides a protected urea intermediate. This intermediate can then be treated with acid to remove the acid-labile protecting group and obtain the compound of formula I.
- the protected urea intermediate can be isolated prior to reacting with acid.
- the acid can be added to a reaction mixture slurry that comprises the protected urea intermediate. The acid may be added in molar excess to the protected urea intermediate, such as about 3 equivalents.
- the protected urea intermediate can bear a carbamate protecting group, such as a t-butylcarbamate protecting group.
- carbamate protecting groups include, for example, 2,2,2-trichloroethyl carbamate, 2- trimethylsilylethyl carbamate, allyl carbamate, benzyl carbamate, 2-phenylethyl carbamate, and 2-chloroethyl carbamate.
- other useful protecting groups include, for example, formamide, benzamide, acetamide, pent-4-enamide, o-nitrophenylacetamide, o- nitrophenoxyacetamide, allyl, JV-4-methoxybenzylamine, and diphenylphosphinamide.
- a variety of acidic conditions may be used to effect transformation of a protected intermediate to a compound of formula I. These include anhydrous or aqueous HCl in methanol, ethanol, tetrahydrofuran, or ethyl acetate; acetyl chloride in methanol; trifluoroacetic acid with or without a sulfide; tolune sulfonic acid; sulfuric acid in dioxane; bromocatechol borane; trimethylsilyl chlroide in phenol/dichloromethane; tetrachlorosilane in phenol/dichloromethane; trimethylsilyl triflate with a sulfide; tert-butyldimethylsilyl triflate; methane sulfonic acid in dioxane/dichloromethane; silica gel; eerie ammonium nitrate in acetonitrile; and zinc in tetrahydr
- the acid can be aqueous HCl in methanol.
- Other conditions to remove acid-labile protecting groups include palladium catalyzed reductions, H 2 with a catalyst, samarium iodide, and iodine in tetrahydrofuran.
- a base can be added, such as triethylamine or sodium carbonate.
- the compound of formula I may be further purified by filtering a warm, such as about 30 0 C, suspension of the compound through a glass filter, then cooling to about 10-15 0 C, adding water and inducing crystallization with a seed crystal of the compound of formula I. Further addition of water with stirring can complete the crystallization process.
- Ri is an aryl ring optionally substituted with one or more R 4 groups selected from halogen, Ci_ 6 alkoxy, Ci_ 6 alkoxycarbonyl, Ci_ 6 alkyl, C 2 - 6 alkenyl, C 2 - 6 alkynyl, amido, amino, aryl, aryloxy, carboxy, cycloalkyl, heterocyclyl, and hydroxy;
- R 2 is -NHC(O)NHR 5 , where R 5 is selected from H, Ci- ⁇ alkyl, Ci_6alkoxycarbonyl, aryl, cycloalkyl, and heterocyclyl;
- R3 is -C(O)NR 6 Ry, where R 6 and R 7 are each independently selected from H, Ci_ 6 alkyl, cycloalkyl and a 5, 6, or 7- membered heterocyclyl ring containing at least one nitrogen atom, provided R 6 and R 7 are not both H; comprising
- Another embodiment of the invention provides a method of preparing a compound of formula I
- Brackets indicate intermediates that are not isolated prior to further reaction.
- Compound 1 can be treated with POCI3 in DMF, followed by addition of hydroxylamine hydrochloride to give compound 4.
- Compound 5 can be reacted with chloroacetyl chloride and pyridine to provide intermediate 6, which gives intermediate 7 upon treatment with potassium thioacetate.
- Addition of compound 4 and sodium methoxide to intermediate 7 results in formation of compound 9.
- Reaction of compound 9 with trichloroacetyl isocyanate can give compound 10, which can be transformed to compound 11 upon treatment with alcoholic triethylamine.
- Compound 11 can be reacted with methanolic HCl to provide compound 12. Salts of compound 12 can be formed by methods described herein below or by methods well known in the art.
- Ri is an aryl ring optionally substituted with one or more R 4 groups selected from halogen, Ci_ 6 alkoxy, Ci_ 6 alkoxycarbonyl, Ci_ 6 alkyl, C 2 - 6 alkenyl, C 2 - 6 alkynyl, amido, amino, aryl, aryloxy, carboxy, cycloalkyl, heterocyclyl, and hydroxy;
- R 2 is -NHC(O)NHR 5 , where R 5 is selected from H, Ci_ 6 alkyl, Ci_ 6 alkoxycarbonyl, aryl, cycloalkyl, and heterocyclyl;
- R3 is -C(O)NR 6 Ry, where R 6 and R 7 are each independently selected from H, cycloalkyl and a 5, 6, or 7- membered heterocyclyl ring containing at least one nitrogen atom, provided R 6 and R 7 are not both H; made by any of the processes disclosed herein.
- Another embodiment provides a composition comprising a compound of formula I made by any of the processes disclosed herein and a pharmaceutically acceptable carrier.
- the following substituents for the variable groups contained in formulae I-VIII are further embodiments of the invention. Such specific substituents may be used, where appropriate, with any of the definitions, claims or embodiments defined hereinbefore or hereinafter.
- R 4 is halogen, such as fluoro.
- Ri is an aryl ring mono-substituted with a fluoro group.
- R 5 is H.
- R 5 is Ci_ 6 alkoxycarbonyl.
- R ⁇ is a 5, 6, or 7-membered heterocyclyl ring and R 7 is H.
- R ⁇ is a 6-membered saturated heterocyclyl containing one nitrogen atom.
- the nitrogen atom is protected by a carbamate protecting group, such as a t- butoxycarbonyl group.
- compound refers to a neutral compound (e.g. a free base), and salt forms thereof (such as pharmaceutically acceptable salts).
- the compound can exist in anhydrous form, or as a hydrate, or as a solvate.
- the compound may be present as stereoisomers (e.g., enantiomers and diastereomers), and can be isolated as enantiomers, racemic mixtures, diastereomers, and mixtures thereof.
- the compound in solid form can exist in various crystalline and amorphous forms.
- C m _ n or "C m _ n group” used alone or as a prefix, refers to any group having m to n carbon atoms.
- alkenyl refers to an unsaturated straight or branched hydrocarbon having at least one carbon-carbon double bond, such as a straight or branched group of 2-12, 2-10, or 2-6 carbon atoms, referred to herein as C 2 -Ci 2 alkenyl, C 2 -Cioalkenyl, and C 2 - C ⁇ alkenyl, respectively.
- alkenyl groups include, but are not limited to, vinyl, allyl, butenyl, pentenyl, hexenyl, butadienyl, pentadienyl, hexadienyl, 2-ethylhexenyl, 2-propyl-2- butenyl, 4-(2-methyl-3-butene)-pentenyl, etc.
- alkoxy refers to an alkyl group attached to an oxygen (-0- alkyl-).
- alkoxy groups include, but are not limited to, groups with an alkyl, alkenyl or alkynyl group of 1-12, 1-8, or 1-6 carbon atoms, referred to herein as Ci-Ci2alkoxy, Ci-Csalkoxy, and Ci-C ⁇ alkoxy, respectively.
- Exemplary alkoxy groups include, but are not limited to methoxy, ethoxy, etc.
- exemplary "alkenoxy” groups include, but are not limited to vinyloxy, allyloxy, butenoxy, etc.
- alkyl refers to a saturated straight or branched hydrocarbon, such as a straight or branched group of 1-12, 1-10, or 1-6 carbon atoms, referred to herein as C 1 - Ci 2 alkyl, Ci-Cioalkyl, and Ci-C ⁇ alkyl, respectively.
- Exemplary alkyl groups include, but are not limited to, methyl, ethyl, propyl, isopropyl, 2 -methyl- 1 -propyl, 2-methyl-2-propyl, 2-methyl-l- butyl, 3-methyl-l -butyl, 2-methyl-3 -butyl, 2,2-dimethyl-l -propyl, 2-methyl-l-pentyl, 3-methyl- 1-pentyl, 4-methyl-l-pentyl, 2-methyl-2-pentyl, 3-methyl-2-pentyl, 4-methyl-2-pentyl, 2,2- dimethyl-l -butyl, 3, 3 -dimethyl- 1 -butyl, 2-ethyl-l -butyl, butyl, isobutyl, t-butyl, pentyl, isopentyl, neopentyl, hexyl, heptyl, octyl, etc.
- Alkyl groups can optionally be substituted with or interrupted by at least one group selected from alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonamide, and sulfonyl.
- alkynyl refers to an unsaturated straight or branched hydrocarbon having at least one carbon-carbon triple bond, such as a straight or branched group of 2-12, 2-8, or 2-6 carbon atoms, referred to herein as C 2 -Ci 2 alkynyl, C 2 _Cgalkynyl, and C 2 - C ⁇ alkynyl, respectively.
- alkynyl groups include, but are not limited to, ethynyl, propynyl, butynyl, pentynyl, hexynyl, methylpropynyl, 4-methyl-l-butynyl, 4-propyl-2-pentynyl, and 4-butyl-2-hexynyl, etc.
- amide or “amido” as used herein refers to a radical of the form -RaC(O)N(Rb)-, -RaC(O)N(Rb)Rc-, or -C(0)NR b Rc, wherein R b and Rc are each independently selected from alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydrogen, hydroxyl, ketone, and nitro.
- the amide can be attached to another group through the carbon, the nitrogen, Rb, Rc, or R ⁇ .
- the amide also may be cyclic, for example Rb and R 0 , Ra and Rb, or R ⁇ and R c may be joined to form a 3- to 12-membered ring, such as a 3- to 10-membered ring or a 5- to 6-membered ring.
- the term "carboxamido" refers to the structure -C(O)NRbRc-
- amine or "amino” as used herein refers to a radical of the form -NRjRg, -N(Rj)Re-, or -RgN(Rd)Rf- where Rj, Rg, and Rf are independently selected from alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydrogen, hydroxyl, ketone, and nitro.
- the amino can be attached to the parent molecular group through the nitrogen, Rj, Rg or R f .
- the amino also may be cyclic, for example any two of Rj, Rg or Rf may be joined together or with the N to form a 3- to 12-membered ring, e.g., morpholino or piperidinyl.
- the term amino also includes the corresponding quaternary ammonium salt of any amino group, e.g., -[N(Rj)(R e )(R f )] + .
- Exemplary amino groups include aminoalkyl groups, wherein at least one of Rd, R e , or Rf is an alkyl group.
- aryl refers to a mono-, bi-, or other multi-carbocyclic, aromatic ring system.
- the aryl group can optionally be fused to one or more rings selected from aryls, cycloalkyls, and heterocyclyls.
- aryl groups of this invention can be substituted with groups selected from alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonamide, and sulfonyl.
- aryl groups include, but are not limited to, phenyl, tolyl, anthracenyl, fluorenyl, indenyl, azulenyl, and naphthyl, as well as benzo-fused carbocyclic moieties such as 5,6,7,8-tetrahydronaphthyl.
- arylalkyl refers to an aryl group having at least one alkyl substituent, e.g. -aryl-alkyl-.
- exemplary arylalkyl groups include, but are not limited to, arylalkyls having a monocyclic aromatic ring system, wherein the ring comprises 6 carbon atoms.
- phenylalkyl includes phenylC 4 alkyl, benzyl, 1-phenylethyl, 2-phenylethyl, etc.
- carboxylate refers to a radical of the form -RgOC(O)N(Rj 1 )-,
- R g? R ⁇ and Ri are each independently selected from alkoxy, aryloxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonyl, and sulfonamide.
- Exemplary carbamates include, but are not limited to, arylcarbamates or heteroaryl carbamates, e.g., wherein at least one of R g R n and R ⁇ are independently selected from aryl or heteroaryl, such as phenyl and pyridinyl.
- carbonyl refers to the radical -C(O)-.
- Carboxamido refers to the radical -C(O)NRR', where R and R' may be the same or different.
- R and R' may be selected from, for example, alkyl, aryl, arylalkyl, cycloalkyl, formyl, haloalkyl, heteroaryl and heterocyclyl.
- carboxy refers to the radical -COOH or its corresponding salts, e.g. -COONa, etc.
- cyano or "nitrile” as used herein refers to the radical -CN.
- cycloalkoxy refers to a cycloalkyl group attached to an oxygen.
- cycloalkyl refers to a monovalent saturated or unsaturated cyclic, bicyclic, or bridged bicyclic hydrocarbon group of 3-12, 3-8, 4-8, or 4-6 carbons, referred to herein, e.g., as "C 4 _ 8 cycloalkyl,” derived from a cycloalkane.
- exemplary cycloalkyl groups include, but are not limited to, cyclohexanes, cyclohexenes, cyclopentanes, cyclopentenes, cyclobutanes and cyclopropanes.
- Cycloalkyl groups may be substituted with alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonamide, and sulfonyl. Cycloalkyl groups can be fused to other cycloalkyl, aryl, or heterocyclyl groups. Fused rings generally refer to at least two rings sharing two atoms therebetween.
- ether refers to a radical having the structure -Ri-0-R m -, where Ri and R m can independently be alkyl, aryl, cycloalkyl, heterocyclyl, or ether.
- the ether can be attached to the parent molecular group through Ri or R m .
- Exemplary ethers include, but are not limited to, alkoxyalkyl and alkoxyaryl groups.
- Ether also includes polyethers, e.g., where one or both of Ri and R m are ethers.
- halo or halogen or “Hal” as used herein refer to F, Cl, Br, or I.
- haloalkyl refers to an alkyl group substituted with one or more halogen atoms.
- heteroaryl refers to a mono-, bi-, or other multi-cyclic, aromatic ring system containing one or more heteroatoms, for example 1 to 4 heteroatoms, such as nitrogen, oxygen, and sulfur. Heteroaryls can be substituted with one or more substituents including alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonamide, and sulfonyl.
- substituents including alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl
- Heteroaryls can also be fused to non-aromatic rings.
- Illustrative examples of heteroaryl groups include, but are not limited to, pyridinyl, pyridazinyl, pyrimidyl, pyrazyl, triazinyl, pyrrolyl, pyrazolyl, imidazolyl, (1,2,3,)- and (1,2,4)- triazolyl, pyrazinyl, pyrimidilyl, tetrazolyl, furyl, thienyl, isoxazolyl, thiazolyl, furyl, phenyl, isoxazolyl, and oxazolyl.
- Exemplary heteroaryl groups include, but are not limited to, a monocyclic aromatic ring, wherein the ring comprises 2 to 5 carbon atoms and 1 to 3 heteroatoms.
- heterocycle refers to a saturated, partially unsaturated, or unsaturated 4-12 membered ring containing at least one heteroatom independently selected from nitrogen, oxygen, and sulfur.
- the heteroatom may be carbon or nitrogen linked, a -CH 2 - group can optionally be replaced by a -C(O)-, and a ring sulfur atom may be optionally oxidized to form a sulfmyl or sulfonyl group.
- Heterocycles can be aromatic (heteroaryls) or non-aromatic.
- Heterocycles can be substituted with one or more substituents including alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonamide, and sulfonyl.
- substituents including alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonamide, and sulfonyl
- Heterocycles also include bicyclic, tricyclic, and tetracyclic groups in which any of the above heterocyclic rings is fused to one or two rings independently selected from aryls, cycloalkyls, and heterocycles.
- Exemplary heterocycles include lH-indazolyl, 2-pyrrolidonyl, 2H, 6H- 1, 5,2-dithiazinyl, 2H-pyrrolyl, 3H-indolyl, 4-piperidonyl, 4aH-carbazolyl, 4H-quinolizinyl, 6H- 1, 2,5-thiadiazinyl, acridinyl, azepanyl, azetidinyl, aziridinyl, azocinyl, benzimidazolyl, benzofuranyl, benzofuryl, benzothiofuranyl, benzothienyl, benzothiophenyl, benzodioxolyl, benzoxazo
- hydroxy and "hydroxyl” as used herein refers to the radical -OH.
- hydroxyalkyl refers to a hydroxy radical attached to an alkyl group.
- nitro refers to the radical -NO2.
- phenyl refers to a 6-membered carbocyclic aromatic ring.
- the phenyl group can also be fused to a cyclohexane or cyclopentane ring.
- Phenyl can be substituted with one or more substituents including alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cyano, cycloalkyl, ester, ether, formyl, halogen, haloalkyl, heteroaryl, heterocyclyl, hydroxyl, ketone, nitro, sulfide, sulfonamide, and sulfonyl.
- sulfonamide refers to a radical having the structure -N(R r )-
- R r , and R 8 can be, for example, hydrogen, alkyl, aryl, cycloalkyl, and heterocyclyl.
- exemplary sulfonamides include alkylsulfonamides (e.g., where R 8 is alkyl), arylsulfonamides (e.g., where R 8 is aryl), cycloalkyl sulfonamides (e.g., where R 8 is cycloalkyl), and heterocyclyl sulfonamides (e.g., where R 8 is heterocyclyl), etc.
- sulfonyl refers to a radical having the structure R u S ⁇ 2-, where R u can be alkyl, aryl, cycloalkyl, and heterocyclyl, e.g., alkylsulfonyl.
- alkylsulfonyl refers to an alkyl group attached to a sulfonyl group.
- sulfide refers to the radical having the structure R 2 S-, where R 2 can be alkoxy, alkyl, alkenyl, alkynyl, amide, amino, aryl, arylalkyl, carbamate, carboxy, cycloalkyl, ester, ether, formyl, haloalkyl, heteroaryl, heterocyclyl, and ketone.
- alkylsulf ⁇ de refers to an alkyl group attached to a sulfur atom.
- Exemplary sulfides include "thio," which as used herein refers to an -SH radical.
- compositions may also contain other active compounds providing supplemental, additional, or enhanced therapeutic functions.
- composition refers to a composition comprising at least one compound as disclosed herein formulated together with one or more pharmaceutically acceptable carriers.
- pharmaceutically acceptable salt(s) refers to salts of acidic or basic groups that may be present in compounds used in the present compositions.
- Compounds included in the present compositions that are basic in nature are capable of forming a wide variety of salts with various inorganic and organic acids.
- the acids that may be used to prepare pharmaceutically acceptable acid addition salts of such basic compounds are those that form nontoxic acid addition salts, i.e., salts containing pharmacologically acceptable anions, including but not limited to malate, oxalate, chloride, bromide, iodide, nitrate, sulfate, bisulfate, phosphate, acid phosphate, isonicotinate, acetate, lactate, salicylate, citrate, tartrate, oleate, tannate, pantothenate, bitartrate, ascorbate, succinate, maleate, gentisinate, fumarate, gluconate, glucaronate, saccharate, formate, benzoate, glutamate, methanesulfonate, ethanesulfonate, benzenesulfonate,/?-toluenesulfonate and pamoate (i.e., l,l'-methylene-bis
- acids having two acidic groups may form salts with a basic compound in the ratio of 1 : 1 or 1 :2 acid:basic compound.
- the salt is a fumarate salt.
- the salt is a hemi-fumarate salt.
- Compounds having an amino moiety may form pharmaceutically acceptable salts with various amino acids, in addition to the acids mentioned above.
- Compounds that are acidic in nature are capable of forming base salts with various pharmacologically acceptable cations. Examples of such salts include alkali metal or alkaline earth metal salts and, particularly, calcium, magnesium, sodium, lithium, zinc, potassium, and iron salts.
- the compounds of the disclosure may contain one or more chiral centers and/or double bonds and, therefore, exist as stereoisomers, such as geometric isomers, enantiomers or diastereomers.
- stereoisomers when used herein consist of all geometric isomers, enantiomers or diastereomers. These compounds may be designated by the symbols “R” or “S,” depending on the configuration of substituents around the stereogenic carbon atom.
- Stereoisomers include enantiomers and diastereomers. Mixtures of enantiomers or diastereomers may be designated "( ⁇ )" in nomenclature, but the skilled artisan will recognize that a structure may denote a chiral center implicitly.
- Individual stereoisomers of compounds of the present invention can be prepared synthetically from commercially available starting materials that contain asymmetric or stereogenic centers, or by preparation of racemic mixtures followed by resolution methods well known to those of ordinary skill in the art. These methods of resolution are exemplified by (1) attachment of a mixture of enantiomers to a chiral auxiliary, separation of the resulting mixture of diastereomers by recrystallization or chromatography and liberation of the optically pure product from the auxiliary, (2) salt formation employing an optically active resolving agent, or (3) direct separation of the mixture of optical enantiomers on chiral chromatographic columns.
- Stereoisomeric mixtures can also be resolved into their component stereoisomers by well known methods, such as chiral-phase gas chromatography, chiral-phase high performance liquid chromatography, crystallizing the compound as a chiral salt complex, or crystallizing the compound in a chiral solvent.
- Stereoisomers can also be obtained from stereomerically-pure intermediates, reagents, and catalysts by well-known asymmetric synthetic methods.
- Geometric isomers can also exist in the compounds of the present invention.
- the present invention encompasses the various geometric isomers and mixtures thereof resulting from the arrangement of substituents around a carbon-carbon double bond or arrangement of substituents around a carbocyclic ring.
- Substituents around a carbon-carbon double bond are designated as being in the "Z” or "E” configuration wherein the terms “Z” and “E” are used in accordance with IUPAC standards.
- structures depicting double bonds encompass both the "E” and "Z” isomers.
- the compounds of the present invention can be prepared in a number of ways well known to one skilled in the art of organic synthesis. More specifically, compounds of the invention may be prepared using the reactions and techniques described herein. In the description of the synthetic methods described below, it is to be understood that all proposed reaction conditions, including choice of solvent, reaction atmosphere, reaction temperature, duration of the experiment and workup procedures, can be chosen to be the conditions standard for that reaction, unless otherwise indicated. It is understood by one skilled in the art of organic synthesis that the functionality present on various portions of the molecule should be compatible with the reagents and reactions proposed. Substituents not compatible with the reaction conditions will be apparent to one skilled in the art, and alternate methods are therefore indicated.
- temperatures are given in degrees Celsius ( 0 C); operations are carried out at room temperature or ambient temperature, such as a range of about 18-25 0 C, unless otherwise stated;
- LC/MS liquid chromatography/mass spectroscopy
- reaction times are given for illustration only;
- final products have been analyzed using proton nuclear magnetic resonance (NMR) spectra and/or mass spectra data;
- yields are given for illustration only and are not necessarily those that can be obtained by diligent process development; preparations can be repeated if more material is desired;
- nuclear magnetic resonance (NMR) data is in the form of delta ( ⁇ ) values for major diagnostic protons, given in part per million (ppm) relative to tetramethylsilane (TMS) as an internal standard, determined at either 300 or 400 MHz in de-DMSO or d 4 -Me0D;
- reaction mixture was then cooled to about 5°C and held at this temperature for a further 20 min before filtration of the solid, displacement washing with two separate portions of water (2 x 240 ml) and drying at about 40 0 C overnight to afford the title compound as a pale yellow solid (74.24 g, 71% yield).
- l-Boc-3-(S)-aminopiperidine (120.0 g, 0.599 mol) was dissolved in 2- methyltetrahydrofuran (540 ml). Pyridine (58.14 ml, 0.719 mol) was added, followed by a line- wash of 2-methyltetrahydrofuran (60 ml). Chloroacetyl chloride (55.32 ml, 0.689 mol) was added dropwise, maintaining the temperature at about 21-25°C, followed by a line wash of 2- methyltetrahydrofuran (60 ml).
- reaction mixture was sampled for conversion to 6 by HPLC before the addition of a 16% w/w aqueous solution of sodium chloride (360 ml). The mixture was stirred for 30 min before separating off the aqueous phase.
- isohexane (960 ml) dropwise before removing a small sample of the reaction mixture, allowing it to cool and returning it to the bulk mixture to seed crystallisation.
- a suspension of 12 (50.0 g, 0.138 mol) in methanol (650 ml) was heated to about 30 0 C for 30 min before filtering the resulting hazy suspension through a 1.6 micron glass microfibre filter paper into a second vessel, followed by a line-wash with methanol (100 ml), discarding the solid residue.
- the resulting solution was cooled to about 10 0 C before addition of water (250 ml), dropwise over 20 min, maintaining the temperature at about 10-15 0 C.
- a sample of purified 12 was then added (150 mg, 0.3% wt/wt), and the contents of the vessel allowed to stir at about 10 0 C for 30 min.
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JP2011506779A JP2011518870A (en) | 2008-04-28 | 2009-04-27 | Process for preparing substituted heterocycles |
EP09738419A EP2283012A1 (en) | 2008-04-28 | 2009-04-27 | Methods of preparing substituted heterocycles |
MX2010011870A MX2010011870A (en) | 2008-04-28 | 2009-04-27 | Methods of preparing substituted heterocycles. |
CN200980125653XA CN102119159A (en) | 2008-04-28 | 2009-04-27 | Methods of preparing substituted heterocycles |
BRPI0911808A BRPI0911808A2 (en) | 2008-04-28 | 2009-04-27 | method for preparing a compound and composition |
CA2722339A CA2722339A1 (en) | 2008-04-28 | 2009-04-27 | Methods of preparing substituted heterocycles - 149 |
US12/989,860 US20110112144A1 (en) | 2008-04-28 | 2009-04-27 | Methods of preparing substituted heterocycles |
AU2009241656A AU2009241656A1 (en) | 2008-04-28 | 2009-04-27 | Methods of preparing substituted heterocycles |
IL208918A IL208918A0 (en) | 2008-04-28 | 2010-10-25 | Methods of preparing substituted heterocycles-149 |
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JP7187308B2 (en) | 2015-09-30 | 2022-12-12 | バーテックス ファーマシューティカルズ インコーポレイテッド | Methods for treating cancer using combinations of DNA damaging agents and ATR inhibitors |
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US20110112144A1 (en) | 2011-05-12 |
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