WO2009126923A3 - Estrogenic extracts of anemarrhena asphodeloides bge from the liliaceae family and uses thereof - Google Patents

Estrogenic extracts of anemarrhena asphodeloides bge from the liliaceae family and uses thereof Download PDF

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Publication number
WO2009126923A3
WO2009126923A3 PCT/US2009/040262 US2009040262W WO2009126923A3 WO 2009126923 A3 WO2009126923 A3 WO 2009126923A3 US 2009040262 W US2009040262 W US 2009040262W WO 2009126923 A3 WO2009126923 A3 WO 2009126923A3
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WO
WIPO (PCT)
Prior art keywords
extracts
anemarrhena asphodeloides
estrogenic
liliaceae family
asphodeloides bge
Prior art date
Application number
PCT/US2009/040262
Other languages
French (fr)
Other versions
WO2009126923A2 (en
Inventor
Isaac Cohen
Original Assignee
Bionovo, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionovo, Inc. filed Critical Bionovo, Inc.
Priority to CA2721080A priority Critical patent/CA2721080A1/en
Priority to AU2009234256A priority patent/AU2009234256A1/en
Priority to EP09730707A priority patent/EP2285394A4/en
Priority to JP2011504218A priority patent/JP2011516579A/en
Publication of WO2009126923A2 publication Critical patent/WO2009126923A2/en
Publication of WO2009126923A3 publication Critical patent/WO2009126923A3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Reproductive Health (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)

Abstract

Estrogenic extracts of Anemarrhena asphodeloides Bge. from the Liliaceae Family are provided. Also provided are methods of using said extracts to achieve an estrogenic effect, especially in a human, e.g. a female human. In some embodiments, the methods include treatment of climacteric symptoms. In some embodiments, the methods include treatment of estrogen receptor positive cancer, such as estrogen responsive breast cancer. In some embodiments, the methods include treatment or prevention of osteoporosis.
PCT/US2009/040262 2008-04-11 2009-04-10 Estrogenic extracts of anemarrhena asphodeloides bge from the liliaceae family and uses thereof WO2009126923A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA2721080A CA2721080A1 (en) 2008-04-11 2009-04-10 Estrogenic extracts of anemarrhena asphodeloides bge. from the liliaceae family and uses thereof
AU2009234256A AU2009234256A1 (en) 2008-04-11 2009-04-10 Estrogenic extracts of Anemarrhena asphodeloides Bge from the Liliaceae Family and uses thereof
EP09730707A EP2285394A4 (en) 2008-04-11 2009-04-10 Estrogenic extracts of anemarrhena asphodeloides bge from the liliaceae family and uses thereof
JP2011504218A JP2011516579A (en) 2008-04-11 2009-04-10 Lilyaceae Hanemashe ANEMARRHENAASPHODELOIDESBGE. Estrogen extract and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4440508P 2008-04-11 2008-04-11
US61/044,405 2008-04-11

Publications (2)

Publication Number Publication Date
WO2009126923A2 WO2009126923A2 (en) 2009-10-15
WO2009126923A3 true WO2009126923A3 (en) 2010-02-25

Family

ID=41162661

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2009/040262 WO2009126923A2 (en) 2008-04-11 2009-04-10 Estrogenic extracts of anemarrhena asphodeloides bge from the liliaceae family and uses thereof

Country Status (6)

Country Link
US (2) US20090297637A1 (en)
EP (1) EP2285394A4 (en)
JP (1) JP2011516579A (en)
AU (1) AU2009234256A1 (en)
CA (1) CA2721080A1 (en)
WO (1) WO2009126923A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2009234256A1 (en) * 2008-04-11 2009-10-15 Bionovo, Inc. Estrogenic extracts of Anemarrhena asphodeloides Bge from the Liliaceae Family and uses thereof
US20100009017A1 (en) * 2008-04-11 2010-01-14 Bionovo, Inc. Anticancer Methods Using Extracts of Anemarrhena asphodeloides Bunge
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
CN103267818B (en) * 2013-05-14 2014-10-22 钟可 Establishing method of rhizoma anemarrhenae HPLC-ELSD (High Performance Liquid Chromatography-Evaporative Light Scattering Detector) fingerprint
CN103816522A (en) * 2014-03-11 2014-05-28 王江军 Chinese medicament for treating hyperplasia of mammary glands
US9988624B2 (en) 2015-12-07 2018-06-05 Zymergen Inc. Microbial strain improvement by a HTP genomic engineering platform
US11208649B2 (en) 2015-12-07 2021-12-28 Zymergen Inc. HTP genomic engineering platform

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874084A (en) * 1996-07-19 1999-02-23 Yng-Wong; Quing Non Using complex herbal formulations to treat hot flashes
US6193977B1 (en) * 1999-03-18 2001-02-27 Medvill Co., Ltd. Pharmaceutical composition comprising an aqueous extract of a mixture of anemarrhena rhizoma and phellodedron bark for analgesic and anti-inflammation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999020223A2 (en) * 1997-10-20 1999-04-29 Novo Nordisk A/S Luteinising hormone antagonists useful for treatment of estrogen deficiencies, or as a contraceptive
KR100416842B1 (en) * 2000-11-29 2004-02-05 신준식 A pharmaceutical preparation for the treatment or prevention of osteoporosis of harpagide-related compound
US6750248B2 (en) * 2001-11-09 2004-06-15 National University Of Singapore Methods for preparing an estrogenic preparation and isolated estrogenic compounds from a plant and uses thereof
CA2467444A1 (en) * 2002-12-04 2004-06-04 Eu Yan Sang (Hong Kong) Limited Medicament for treatment of climacteric syndrome of women and preparation method thereof
AU2009234256A1 (en) * 2008-04-11 2009-10-15 Bionovo, Inc. Estrogenic extracts of Anemarrhena asphodeloides Bge from the Liliaceae Family and uses thereof
US20100009017A1 (en) * 2008-04-11 2010-01-14 Bionovo, Inc. Anticancer Methods Using Extracts of Anemarrhena asphodeloides Bunge

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874084A (en) * 1996-07-19 1999-02-23 Yng-Wong; Quing Non Using complex herbal formulations to treat hot flashes
US6193977B1 (en) * 1999-03-18 2001-02-27 Medvill Co., Ltd. Pharmaceutical composition comprising an aqueous extract of a mixture of anemarrhena rhizoma and phellodedron bark for analgesic and anti-inflammation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Protective effect of steroidal saponins from rhizome of Anemarrhena asphodeloides on ovariectomy-induced bone loss in rats", ACTA PHARMACOL SIN., vol. 27, no. 6, June 2006 (2006-06-01), pages 728 - 734, XP008145461 *

Also Published As

Publication number Publication date
JP2011516579A (en) 2011-05-26
US20090297638A1 (en) 2009-12-03
US20090297637A1 (en) 2009-12-03
EP2285394A4 (en) 2012-03-07
CA2721080A1 (en) 2009-10-15
EP2285394A2 (en) 2011-02-23
WO2009126923A2 (en) 2009-10-15
AU2009234256A1 (en) 2009-10-15

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