WO2009126675A1 - 2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10 - Google Patents

2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10 Download PDF

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Publication number
WO2009126675A1
WO2009126675A1 PCT/US2009/039850 US2009039850W WO2009126675A1 WO 2009126675 A1 WO2009126675 A1 WO 2009126675A1 US 2009039850 W US2009039850 W US 2009039850W WO 2009126675 A1 WO2009126675 A1 WO 2009126675A1
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Prior art keywords
propyl
cyano
pyrrol
carbonyl
methylpiperidin
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PCT/US2009/039850
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French (fr)
Inventor
Asitha Abeywardane
Derek Cogan
Younggi Choi
Donghong A. Gao
Daniel R. Goldberg
Alexander Heim-Riether
Craig Andrew Miller
Philip Dean Ramsden
Lana Louise Smith Keenan
Roger John Snow
Yang Yu
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Boehringer Ingelheim International Gmbh
Boehringer Ingelheim Pharma Gmbh & Co. Kg
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Application filed by Boehringer Ingelheim International Gmbh, Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim International Gmbh
Priority to US12/937,006 priority Critical patent/US8586748B2/en
Priority to CA2720613A priority patent/CA2720613A1/en
Priority to JP2011504143A priority patent/JP5492189B2/en
Priority to EP09730594A priority patent/EP2276731A1/en
Publication of WO2009126675A1 publication Critical patent/WO2009126675A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Definitions

  • This invention relates to substituted amides that are useful as inhibitors of CCRlO activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCRlO including inflammatory skin diseases, allergic asthma and melanoma.
  • This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
  • Chemokine receptors play an important role in mediating tissue specific recruitment of leukocytes to sites of inflammation.
  • memory T cells that preferentially homes to the skin. This subset is defined by expression of the cutaneous lymphocyte antigen (CLA), a lectin, which binds to E-selectin on dermal endothelial cells and promotes trafficking.
  • CLA cutaneous lymphocyte antigen
  • the subset of CLA-expressing cells constitutes only 10- 15% of the circulating T cell pool, these cells are found in abundance within several inflammatory skin lesions, for example, psoriasis, contact sensitivity and allergic dermatitis.
  • CLA + memory cells also express the chemokine receptor CCRlO and that cells expressing CCRlO are enriched in inflammatory skin lesions.
  • CCL27 One ligand for this receptor, CCL27, is also markedly up-regulated at these sites suggesting that this chemokine receptor may participate in mediating the tissue-specific trafficking of CLA + memory T cells.
  • CCL27 expression has been shown to be tightly regulated with abundant expression in the epidermis, predominantly by keratinocytes.
  • CCRlO antagonism of the interaction between CCRlO and its skin derived ligand CCL27 could therefore be of benefit in the treatment of inflammatory skin diseases by blocking the entry and activation of T cells within the skin.
  • One indication for a CCRlO antagonist would be psoriasis.
  • the rationale is based on histological studies of receptor/ligand expression in humans with psoriasis and proof of concept studies in animal models of skin inflammation. From analysis of normal and diseased skin samples, it is clear that the expression of CCRlO is highly regulated and restricted primarily to a subset of skin homing (CLA + ) lymphocytes, dermal endothelial cells, and dermal fibroblasts.
  • CLA + skin homing
  • CCL27 a ligand for CCRlO
  • CCL27 is also expressed in keratinocytes.
  • CCL27 is expressed by keratinocytes in the basal layers of the epidermis.
  • this ligand is up- regulated with expression extending to the suprabasal layers of the epidermis and histological staining also evident on the dermal microvasculature.
  • the enhanced expression of CCL27 is accompanied by an increased presence of CCRlO + lymphocytes.
  • CCRlO may also be a promising target for treatment of contact sensitivity and allergic dermatitis. It has been shown recently that CCL27 is increased in the sera of patients with systemic sclerosis and in the dermis of UV-induced cutaneous SLE (systemic lupus erythematosus) lesions. Therefore, systemic sclerosis and cutaneous SLE could also be additional indications. In addition, inflammation of the respiratory tract in a murine model of allergic asthma is associated with CCL28 and CCRlO expression suggesting that inhibition of CCRlO activity may also be useful in treatment of allergic asthma.
  • Antagonism of CCRlO may also be beneficial for the treatment of melanoma.
  • melanoma lines expressing CCRlO form tumors more readily than matched CCRlO deficient melanomas and that a blocking antibody against CCL27 can block the growth of these CCRlO + melanoma cells in vivo.
  • the present invention is directed to the compounds of the following formula (I):
  • the present invention is directed to a method of inhibiting CCRlO activity in an individual comprising administering to the individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
  • the present invention is directed to a method of treating a disease or disorder associated with the activation of CCRlO comprising administering to an individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
  • the present invention is directed to a method of treating an inflammatory skin disease comprising administering to an individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
  • diseases include, for example, psoriasis, contact sensitivity, allergic dermatitis, systemic sclerosis, and cutaneous SLE.
  • the present invention is directed to a method of treating allergic asthma comprising administering to an individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
  • the present invention is directed to a method of treating melanoma comprising administering to an individual in need of such treatment a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
  • the present invention is directed to pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
  • the present invention also includes the processes for preparing the above-mentioned compounds and intermediates used in these processes.
  • Ar is phenyl, naphthyl or heteroaryl. selected from indolyl, pyridyl, thienyl, pyrazolyl, oxazolyl, indazolyl, benzimidazolyl, isoquinolinyl, lH-pyrrolo[2,3-b]pyridinyl, benzothienyl, benzofuranyl, 2,1,3-benzothiadiazolyl and 6H-imidazo[2,l-b]thiazolyl, wherein said phenyl naphthyl or heteroaryl is optionally substituted with one to four groups selected from Ci- ⁇ alkyl, Ci- ⁇ alkoxy, phenyl, heteroaryl, phenyloxy, halogen, -NH 2 , -NHC(O)NH 2 , -NHC(O)Ci_ 6 alkyl, -NO 2 , -CF 3 , -OCF 3 , -CN, -C(
  • Ar is phenyl
  • two adjacent groups together with the phenyl they are bonded to may form a 2,3-dihydrobenzofuranyl, l,3-dihydroindol-2-one, or 2-acetyl-3,4-dihydro-lH-isoquinolinyl group;
  • Het is a heteroaryl group selected from:
  • R 1 and R 2 are independently selected from Ci- 6 alkyl, arylCi_ 2 alkyl, phenyl, naphthyl and C 3 .
  • gcycloalkyl wherein said arylCi_ 2 alkyl is optionally substituted with one to two groups selected from halogen, Ci- 6 alkoxy, Ci- 6 alkyl, -CF 3 , imidazolyl, pyridyl, pyrimidinyl, pyrazolyl, 5-methyloxadiazolyl, morpholinyl, piperidinyl and N-methyl-1, 2,3,4- tetrahydroisoquinolinyl; or
  • R 1 and R 2 together with the N they are bonded to form a heterocycle selected from piperidine, morpholine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, azepane, 6-aza-spiro[2.5]octane, 2,3,4,5-tetrahydro-lH-benzo[b]azepine, [l,4]-diazepane, [1,4]- oxazepane, thiomorpholine, thiomorpholine, thiomorpholine 1,1 -dioxide, 4,5,6,7- tetrahydrothieno[3,2-c]pyridine, , 5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3-a]pyrazine, 5,6,7,8- tetrahydro-imidazo[l,5- ⁇ ]pyrazine, 4,5,6,7-tetrahydro-thia
  • R 4 is hydrogen or Ci- 6 alkyl; or a pharmaceutically acceptable salt thereof.
  • Ar is phenyl, naphthyl or heteroaryl selected from indolyl, pyridyl, thienyl, pyrazolyl, indazolyl, isoquinolinyl, benzothienyl, benzofuranyl, and 6H-imidazo[2,l-b]thiazolyl, wherein said phenyl naphthyl or heteroaryl is optionally substituted with one to four groups selected from CH 3 , -CH 2 CH 3 , -OCH 3 , Cl, Br, F, -NH 2 , C(O)CH 3 , NHC(O)CH 3 , -CF 3 , -OCF 3 , -CN and -CO 2 CH 3 ; or
  • Ar is phenyl
  • two adjacent groups together with the phenyl they are bonded to may form a 2,3-dihydrobenzofuranyl or oxindolyl group
  • Het is a heteroaryl group selected from
  • R 3 is selected from -CN, -NO 2 , Cl, Br, -C(O)NH 2 and CO 2 Me;
  • R 1 is CH 3 and R 2 is benzyl, wherein said benzyl is optionally substituted with one to two groups selected from halogen, Ci_ 6 alkoxy, Ci- ⁇ alkyl, -CF 3 , imidazolyl, pyridyl, pyrimidinyl, pyrazolyl, 5-methyloxadiazolyl, morpholinyl, piperidinyl and N-methyl-1, 2,3,4- tetrahydroisoquinolinyl; or
  • R 1 and R 2 together with the N they are bonded to form a heterocycle selected from piperidine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, 6-aza- spiro[2.5]octane, azepane, [l,4]-diazepane and [l,4]-oxazepane, 4,5,6,7-tetrahydrothieno[3,2- c]pyridine, 5,6,7,8-tetrahydro-imidazo[l,5- ⁇ ]pyrazine, 1,2,3,6-tetrahydropyridine, 5,6,7,8- tetrahydro-[l,2,4]triazolo[4,3-a]pyrazine, 2,3,4,5-tetrahydro-lH-benzo[b]azepine and 1,2,3,6- tetrahydropyridine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_ 6 alky
  • R 4 is hydrogen; or a pharmaceutically acceptable salt thereof.
  • Ar is phenyl, indolyl, thienyl or indazolyl, wherein each is optionally substituted with one to three groups selected from CH 3 , -CH 2 CH 3 , -OCH 3 , Cl, Br, F, -NH 2 , and -CF 3 ;
  • Het is a heteroaryl group selected from
  • R 3 is selected from -CN, -NO 2 , Cl, Br, -C(O)NH 2 and CO 2 Me;
  • R 1 and R 2 together with the N they are bonded to, form a heterocycle selected from piperidine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, 6-aza- spiro[2.5]octane, azepane, [l,4]-diazepane and [l,4]-oxazepane, 1,2,3,6-tetrahydrpyridine and 4,5,6,7-tetrahydrothieno[3,2-c]pyridine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_ 6 alkyl, (CH 2 )o- 2 OH, -CF 3 , -CN, Cl, Br, F, -(CH 2 )( M CO 2 H, -(CH 2 )o- 4 C0 2 Ci_ 6 alkyl, -C(O)N(CH 3 ) 2 , -C(O)NHCH 3 , -C(O)NH 2 ,
  • R 4 is hydrogen; or a pharmaceutically acceptable salt thereof.
  • Ci_ 6 alkoxy is a Ci_ 4 alkyl that contain an oxygen atom, such as methoxy, ethoxy, propoxy, or butoxy.
  • Ci_io-alkyl refers to branched and unbranched alkyl groups with 1 to 10 carbon atoms
  • Ci_ 6 -alkyl accordingly means branched and unbranched alkyl groups with 1 to 6 carbon atoms
  • Ci_ 4 -alkyl accordingly denotes branched and unbranched alkyl groups with 1 to 4 carbon atoms. Alkyl groups with 1 to 4 carbon atoms are preferred.
  • Examples include: methyl, ethyl, «-propyl, ⁇ o-propyl, «-butyl, ⁇ o-butyl, sec-butyl, tert-buty ⁇ , «-pentyl, ⁇ o-pentyl, «eo-pentyl or hexyl.
  • the abbreviations Me, Et, «-Pr, /-Pr, «-Bu, /-Bu, f-Bu, etc. may also be used for the above-mentioned groups.
  • the definitions propyl, butyl, pentyl and hexyl include all the possible isomeric forms of the groups in question.
  • propyl includes «-propyl and ⁇ -propyl
  • butyl includes ⁇ o-butyl, sec-butyl and tert-butyl etc.
  • C 2 - 6 -alkenyl refers to branched and unbranched alkenyl groups with 2 to 6 carbon atoms and by the term “C 2 - 4 -alkenyl” refers to branched and unbranched alkenyl groups with 2 to 4 carbon atoms, provided that they have at least one double bond. Alkenyl groups with 2 to 4 carbon atoms are preferred. Examples include: ethenyl or vinyl, propenyl, butenyl, pentenyl, or hexenyl.
  • propenyl, butenyl, pentenyl and hexenyl include all the possible isomeric forms of the groups in question.
  • propenyl includes 1 -propenyl and 2- propenyl
  • butenyl includes 1-, 2- and 3-butenyl, 1 -methyl- 1 -propenyl, 1 -methyl-2-propenyl etc.
  • C 2 - 6 -alkynyl refers to branched and unbranched alkynyl groups with 2 to 6 carbon atoms and by the term “C 2 - 4 -alkynyl” refers to branched and unbranched alkynyl groups with 2 to 4 carbon atoms, provided that they have at least one triple bond.
  • Alkynyl groups with 2 to 4 carbon atoms are preferred. Examples include: ethynyl, propynyl, butynyl, pentynyl or hexynyl.
  • propynyl, butynyl, pentynyl and hexynyl include all the possible isomeric forms of the groups in question.
  • propynyl includes 1 -propynyl and 2- propynyl
  • butynyl includes 1, 2- and 3 -butynyl, 1 -methyl- 1 -propynyl, 1 -methyl-2-propynyl etc.
  • cycloalkyl shall be understood to mean an aliphatic hydrocarbon radical containing from three to twelve carbon atoms. Cycloalkyls include hydrocarbon rings containing from three to ten carbon atoms. These cycloalkyls may be either aromatic or non- aromatic ring systems. The non-aromatic ring systems may be mono- or polyunsaturated.
  • Preferred cycloalkyls include, but are not limited, to cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptanyl, cycloheptenyl, phenyl, indanyl, indenyl, benzocyclobutanyl, dihydronaphthyl, tetrahydronaphthyl, naphthyl, decahydronaphthyl, benzocycloheptanyl, and benzocycloheptenyl. Certain terms for cycloalkyl, such as cyclobutanyl and cyclobutyl, shall be used inerchangeably.
  • heterocycle refers to a stable, nonaromatic, 4-8 membered (but preferably 5 or 6 membered) monocyclic or nonaromatic, 8-11 membered, bicyclic heterocycle radical that may be either saturated or unsaturated.
  • Each heterocycle consists of carbon atoms and at least one, i.e., 1-4, heteroatoms chosen from, e.g., nitrogen, oxygen, or sulfur.
  • the heterocycle may be attached by any atom of the cycle that results in the creation of a stable structure.
  • heterocycles include, but are not limited to, for example, aziridinyl, azetidinyl, pyrrolidinyl, pyrrolinyl, morpholinyl, thiomorpholinyl, thiomorpholinyl sulfoxide, thiomorpholinyl sulfone, dioxalanyl, piperidinyl, piperazinyl, tetrahydrofuranyl, 1 -oxo-lambda-4-thiomorpholinyl, 13-oxa- 11 -aza-tricyclo[7.3.1.0- 2,7]trideca-2,4,6-triene, tetrahydropyranyl, 2-oxo-2H-pyranyl, tetrahydrofuranyl, 1,3- dioxolanone, 1,3-dioxanone, 1,4-dioxanyl, 8-oxa-3-aza-bicyclo[3.2.1]octanyl
  • heteroaryl shall be understood to mean an aromatic 5-8 membered monocyclic or 8-11 membered bicyclic ring containing 1-4 heteroatoms, such as N, O, and S. Unless otherwise stated, such heteroaryls include thienyl, furanyl, isoxazolyl, oxazolyl, thiazolyl, thiadiazolyl, tetrazolyl, pyrazolyl, pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyranyl, quinoxalinyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, benzothienyl, quinolinyl, quinazolinyl, naphthyridinyl, indazolyl, triazolyl, pyrazolo[3,4- b]pyrimidinyl,
  • one or more carbon atoms can be optionally replaced by heteroatoms, such as O, S, or N. It shall be understood that, if N is not substituted, then it is NH. It shall also be understood that heteroatoms may replace either terminal carbon atoms or internal carbon atoms within a branched or unbranched carbon chain.
  • groups can be substituted as herein above described by groups, such as oxo, to result in definitions, such as, but not limited to, alkoxycarbonyl, acyl, amido, and thioxo.
  • aryl shall be understood to mean aromatic cycloalkyl or heteroaryl as defined herein.
  • Each aryl unless otherwise specified includes it's partially or fully hydrogenated derivative.
  • quinolinyl may include decahydroquinolinyl and tetrahydroquinolinyl
  • naphthyl may include its hydrogenated derivatives, such as tetrahydranaphthyl.
  • Other partially or fully hydrogenated derivatives of the aryl compounds described herein will be apparent to one of ordinary skill in the art.
  • nitrogen and sulfur include any oxidized form of nitrogen and sulfur and the quaternized form of any basic nitrogen.
  • -S-Ci -6 alkyl radical unless otherwise specified, this shall be understood to include -S(O)-Ci_6 alkyl and -S(O) 2 -Ci -6 alkyl.

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Abstract

This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.

Description

2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE
ANTAGONISTS OF CCR10
Background of the Invention
Field of the Invention
This invention relates to substituted amides that are useful as inhibitors of CCRlO activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCRlO including inflammatory skin diseases, allergic asthma and melanoma. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.
Brief Description of the Art
Chemokine receptors play an important role in mediating tissue specific recruitment of leukocytes to sites of inflammation. Within the blood there is a subset of memory T cells that preferentially homes to the skin. This subset is defined by expression of the cutaneous lymphocyte antigen (CLA), a lectin, which binds to E-selectin on dermal endothelial cells and promotes trafficking. Although the subset of CLA-expressing cells constitutes only 10- 15% of the circulating T cell pool, these cells are found in abundance within several inflammatory skin lesions, for example, psoriasis, contact sensitivity and allergic dermatitis. Recent studies have revealed that CLA+ memory cells also express the chemokine receptor CCRlO and that cells expressing CCRlO are enriched in inflammatory skin lesions. One ligand for this receptor, CCL27, is also markedly up-regulated at these sites suggesting that this chemokine receptor may participate in mediating the tissue-specific trafficking of CLA+ memory T cells. Within the skin, expression of CCRlO has been reported on CLA+ T cells, melanocytes, fibroblasts, and microvascular endothelial cells. CCL27 expression has been shown to be tightly regulated with abundant expression in the epidermis, predominantly by keratinocytes.
There is evidence in both humans and in rodents that the CCR10-CCL27 interaction plays an important role in the trafficking of inflammatory T cell subsets to skin lesions. By histological analysis, it is clear that, in addition to the increase in epidermal expression of CCL27 observed in psoriatic and atopic dermatitis biopsies, there is also expanded expression of CCL27 into the dermal layer as well. Further, endothelial cells within the vasculature of these lesions also display CCL27, though they are negative for CCL27 message, suggesting that keratinocyte-derived CCL27 can be captured by endothelial cells and presented to circulating leukocytes. Accompanying these changes in the skin is a marked increase in the recruitment of lymphocytes that co-express CLA and CCRlO. Consistent with the role of CCL27 in skin inflammation, IL-I beta and TNF alpha treatment of cultured keratinocytes induces expression of CCL27.
Cutaneous application of nickel, in nickel-allergic humans, led to the up-regulated expression of CCL27 and the subsequent recruitment of CCRlO+ lymphocytes. Thus, these studies provide temporal support for the role of CCL27 in attracting CCRlO+ cells. Furthermore, in vivo proof of concept has been shown in wild-type mice where treatment with a function blocking antibody against CCL27 clearly diminished recruitment and swelling in both DNFB-induced and ovalbumin DTH models of dermatitis. These authors also demonstrated the ability of cutaneous injection of CCL27 to promote local lymphocyte trafficking and inflammation, thus providing proof of concept using both ligand and antibody in relevant animal models. Consistent with its ascribed in vivo role, CCL27 induces calcium flux in CCRlO+ cells and mediates the selective chemotaxis Of CLA+ CCRlO+ lymphocytes in vitro.
Studies, such as those described above, suggest that antagonism of the interaction between CCRlO and its skin derived ligand CCL27 could therefore be of benefit in the treatment of inflammatory skin diseases by blocking the entry and activation of T cells within the skin. One indication for a CCRlO antagonist would be psoriasis. The rationale is based on histological studies of receptor/ligand expression in humans with psoriasis and proof of concept studies in animal models of skin inflammation. From analysis of normal and diseased skin samples, it is clear that the expression of CCRlO is highly regulated and restricted primarily to a subset of skin homing (CLA+) lymphocytes, dermal endothelial cells, and dermal fibroblasts. In addition, CCL27, a ligand for CCRlO, is also expressed in keratinocytes. In normal skin, CCL27 is expressed by keratinocytes in the basal layers of the epidermis. However, in the skin of atopic dermatitis and psoriasis patients this ligand is up- regulated with expression extending to the suprabasal layers of the epidermis and histological staining also evident on the dermal microvasculature. The enhanced expression of CCL27 is accompanied by an increased presence of CCRlO+ lymphocytes. Finally the proof of concept studies described above demonstrated that a function blocking antibody directed against CCL27 blocked trafficking of lymphocytes and swelling in two murine models of dermatitis. Based on the pattern of expression for both CCRlO and CCL27 and the above proof of concept studies, CCRlO may also be a promising target for treatment of contact sensitivity and allergic dermatitis. It has been shown recently that CCL27 is increased in the sera of patients with systemic sclerosis and in the dermis of UV-induced cutaneous SLE (systemic lupus erythematosus) lesions. Therefore, systemic sclerosis and cutaneous SLE could also be additional indications. In addition, inflammation of the respiratory tract in a murine model of allergic asthma is associated with CCL28 and CCRlO expression suggesting that inhibition of CCRlO activity may also be useful in treatment of allergic asthma.
Antagonism of CCRlO may also be beneficial for the treatment of melanoma. In a mouse model of melanoma metastasis, it has been demonstrated that melanoma lines expressing CCRlO form tumors more readily than matched CCRlO deficient melanomas and that a blocking antibody against CCL27 can block the growth of these CCRlO+ melanoma cells in vivo. These observations, coupled with the finding that many human melanomas express CCRlO, provide the rationale for considering this as a further indication. Brief Summary of the Invention
In a general aspect, the present invention is directed to the compounds of the following formula (I):
Figure imgf000006_0001
(I) wherein Ar, Het, R1 R2 and R4 are as defined herein, as well as the tautomers thereof, and salts thereof. It has been found that the compounds of formula (I) have valuable pharmacological properties, particularly an inhibiting activity of CCRlO activity.
In another aspect, the present invention is directed to a method of inhibiting CCRlO activity in an individual comprising administering to the individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
In another aspect, the present invention is directed to a method of treating a disease or disorder associated with the activation of CCRlO comprising administering to an individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
In another aspect, the present invention is directed to a method of treating an inflammatory skin disease comprising administering to an individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof. Examples of such diseases that may be treated include, for example, psoriasis, contact sensitivity, allergic dermatitis, systemic sclerosis, and cutaneous SLE.
In another aspect, the present invention is directed to a method of treating allergic asthma comprising administering to an individual a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof. In another aspect, the present invention is directed to a method of treating melanoma comprising administering to an individual in need of such treatment a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof.
In yet additional aspects, the present invention is directed to pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.
The present invention also includes the processes for preparing the above-mentioned compounds and intermediates used in these processes.
Detailed Description of the Invention
In an embodiment there is provided compounds of formula (I):
Figure imgf000008_0001
wherein:
Ar is phenyl, naphthyl or heteroaryl. selected from indolyl, pyridyl, thienyl, pyrazolyl, oxazolyl, indazolyl, benzimidazolyl, isoquinolinyl, lH-pyrrolo[2,3-b]pyridinyl, benzothienyl, benzofuranyl, 2,1,3-benzothiadiazolyl and 6H-imidazo[2,l-b]thiazolyl, wherein said phenyl naphthyl or heteroaryl is optionally substituted with one to four groups selected from Ci-βalkyl, Ci-βalkoxy, phenyl, heteroaryl, phenyloxy, halogen, -NH2, -NHC(O)NH2, -NHC(O)Ci_6alkyl, -NO2, -CF3, -OCF3, -CN, -C(O)Ci_6alkyl, -(CH2)0-2CO2Ci_6alkyl, -(CH2)O- 2CO2H, 5-tetrazolyl, -CHO, -C(O)NH2, -C(O)NH(d_6alkyl) and -C(O)N(C1-6a]kyl)2; or
if Ar is phenyl, two adjacent groups together with the phenyl they are bonded to may form a 2,3-dihydrobenzofuranyl, l,3-dihydroindol-2-one, or 2-acetyl-3,4-dihydro-lH-isoquinolinyl group;
Het is a heteroaryl group selected from:
Figure imgf000009_0001
Figure imgf000009_0002
and
and is optionally substituted with one to two groups independently selected from
-CN, -NO2, halogen, -d_6alkyl, -C(O)NH2 and CO2Me;
R1 and R2 are independently selected from Ci-6alkyl, arylCi_2alkyl, phenyl, naphthyl and C3. gcycloalkyl, wherein said arylCi_2alkyl is optionally substituted with one to two groups selected from halogen, Ci-6alkoxy, Ci-6alkyl, -CF3, imidazolyl, pyridyl, pyrimidinyl, pyrazolyl, 5-methyloxadiazolyl, morpholinyl, piperidinyl and N-methyl-1, 2,3,4- tetrahydroisoquinolinyl; or
R1 and R2, together with the N they are bonded to form a heterocycle selected from piperidine, morpholine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, azepane, 6-aza-spiro[2.5]octane, 2,3,4,5-tetrahydro-lH-benzo[b]azepine, [l,4]-diazepane, [1,4]- oxazepane, thiomorpholine, thiomorpholine, thiomorpholine 1,1 -dioxide, 4,5,6,7- tetrahydrothieno[3,2-c]pyridine, , 5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3-a]pyrazine, 5,6,7,8- tetrahydro-imidazo[l,5-α]pyrazine, 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 1,2,3,6- tetrahydropyridine and octahydropyrido[l,2-a]pyrazine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_6alkyl, Ci_6alkenyl, phenyl, benzyl, hydroxyCi_6alkyl, -OH, -CFj, -CN, halogen, -NO2, -NH2, oxo, 1,3-dioxolane, -CH=NOCH3, -SO2NH2, -SO2N(C1_6alkyl)2, -SO3H, -SO2(C1_6alkyl)2, -C(O)N(C1_6alkyl)2, -C(O)NHCi_6alkyl, -(CH2)0-2C(O)NH2, -(CH2)O-4CO2H, -(CH2)o-4C02Ci_6alkyl, =C-CO2Ci_ galkyl, -CH=CH-CO2H, -CH=CH-CO2Ci_6alkyl, -OCH2CO2H, -OCH2CO2Ci_6alkyl, -OC(CH3)2CO2H, -OC(CH3)2CO2Ci_6alkyl, -C(O)CH2CO2H, -C(O)CH2CO2Ci_6alkyl, -C(O)Ci_6alkyl, -C(O)Ci_4alkyl(OH), -CH2OCi_6alkyl, -(CH2)0-2NHC(O)Ci_6alkyl, -C(O)morpholinyl, thiazole, 3-methyl-l,2,4-oxadiazolyl, pyrimidine and 2-[l,2,4]oxadiazol- 3-ylpyrazine; and
R4 is hydrogen or Ci-6alkyl; or a pharmaceutically acceptable salt thereof.
In another embodiment, there are provided compounds of formula (I), wherein: Ar is phenyl, naphthyl or heteroaryl selected from indolyl, pyridyl, thienyl, pyrazolyl, indazolyl, isoquinolinyl, benzothienyl, benzofuranyl, and 6H-imidazo[2,l-b]thiazolyl, wherein said phenyl naphthyl or heteroaryl is optionally substituted with one to four groups selected from CH3, -CH2CH3, -OCH3, Cl, Br, F, -NH2, C(O)CH3, NHC(O)CH3, -CF3, -OCF3, -CN and -CO2CH3; or
if Ar is phenyl, two adjacent groups together with the phenyl they are bonded to may form a 2,3-dihydrobenzofuranyl or oxindolyl group;
Het is a heteroaryl group selected from
Figure imgf000011_0001
wherein R3 is selected from -CN, -NO2, Cl, Br, -C(O)NH2 and CO2Me;
R1 is CH3 and R2 is benzyl, wherein said benzyl is optionally substituted with one to two groups selected from halogen, Ci_6alkoxy, Ci-βalkyl, -CF3, imidazolyl, pyridyl, pyrimidinyl, pyrazolyl, 5-methyloxadiazolyl, morpholinyl, piperidinyl and N-methyl-1, 2,3,4- tetrahydroisoquinolinyl; or
R1 and R2, together with the N they are bonded to form a heterocycle selected from piperidine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, 6-aza- spiro[2.5]octane, azepane, [l,4]-diazepane and [l,4]-oxazepane, 4,5,6,7-tetrahydrothieno[3,2- c]pyridine, 5,6,7,8-tetrahydro-imidazo[l,5-α]pyrazine, 1,2,3,6-tetrahydropyridine, 5,6,7,8- tetrahydro-[l,2,4]triazolo[4,3-a]pyrazine, 2,3,4,5-tetrahydro-lH-benzo[b]azepine and 1,2,3,6- tetrahydropyridine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_6alkyl, Ci_6alkenyl, phenyl, benzyl, -CFj, -CN, Cl, Br, F, -NO2, oxo, -CH=NOCH3, SO2NH2, -SO2N(CH3)2, -SO3H, -SO2(CH3), -C(O)N(CH3)2, -C(O)NHCH3, -(CH2V2C(O)NH2, -(CH2)o-4C02H, -(CH2)0^CO2Ci_2alkyl, -(CH2)0-4OH, -CH=CH-CO2H, -CH=CH-CO2Ci_2alkyl, =C-CO2Ci_6alkyl, -OCH2CO2H, -OCH2CO2Ci_2alkyl, -OC(CH3)2CO2H, -OC(CH3)2CO2Ci_2alkyl, -C(O)CH2CO2H, -C(O)CH2CO2Ci_2alkyl, -C(O)CH3, -C(O)Ci_4alkyl(OH), -CH2OCH3, -(CH2)0-2NHC(O)CH3, -C(O)morpholinyl, thiazole, 3-methyl-l,2,4-oxadiazolyl, pyrimidine and 2-[l,2,4]oxadiazol-3-ylpyrazine; and
R4 is hydrogen; or a pharmaceutically acceptable salt thereof.
In still another embodiment, there are provided compounds of formula (I), wherein:
Ar is phenyl, indolyl, thienyl or indazolyl, wherein each is optionally substituted with one to three groups selected from CH3, -CH2CH3, -OCH3, Cl, Br, F, -NH2, and -CF3;
Het is a heteroaryl group selected from
Figure imgf000012_0001
wherein R3 is selected from -CN, -NO2, Cl, Br, -C(O)NH2 and CO2Me;
R1 and R2, together with the N they are bonded to, form a heterocycle selected from piperidine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, 6-aza- spiro[2.5]octane, azepane, [l,4]-diazepane and [l,4]-oxazepane, 1,2,3,6-tetrahydrpyridine and 4,5,6,7-tetrahydrothieno[3,2-c]pyridine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_6alkyl, (CH2)o-2OH, -CF3, -CN, Cl, Br, F, -(CH2)(MCO2H, -(CH2)o-4C02Ci_6alkyl, -C(O)N(CH3)2, -C(O)NHCH3, -C(O)NH2, -C(O)CH3, -CH=CH-CO2H, -OC(CH3)2CO2H, -OC(CH3)2CO2H and -C(O)CH2CO2H; and
R4 is hydrogen; or a pharmaceutically acceptable salt thereof.
In still a further embodiment of the invention, there are provided compounds of the formula (I) selected from the group below or a tautomer thereof or a salt thereof:
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } benzenesulfonamide
Figure imgf000013_0001
N-[l-(piperidin-l-ylcarbonyl)-3-(lH- pyrazol- 1 -yl)propyl] - 1 H-indole-4- sulfonamide
Figure imgf000013_0002
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } thiophene- 3 - sulfonamide
Figure imgf000014_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2-methylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
3-methylbenzenesulfonamide
Figure imgf000014_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
4-methylbenzenesulfonamide
Figure imgf000014_0004
N- { 1 - [(4-methylpiperidin- 1 - yl)carbonyl]-3-(lH-pyrazol-l- yl)propyl}-lH-indole-4-sulfonamide
Figure imgf000014_0005
N- { 1 - [(4-methylpiperidin- 1 - yl)carbonyl]-3-(lH-pyrazol-l- yl)propyl } - 1 H-indole- 6- sulfonamide
Figure imgf000014_0006
Example Structure Name
N- { 1 - [(4-methylpiperidin- 1 - yl)carbonyl]-3-(2H-l,2,3-triazol-2- yl)propyl}-lH-indole-4-sulfonamide
Figure imgf000015_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
3,5-dimethylisoxazole-4-sulfonamide
2-cyano-N- { 3-(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl }
Figure imgf000015_0002
benzenesulfonamide
3-cyano-N- { 3-(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl } benzenesulfonamide
Figure imgf000015_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
13 methylpiperidin- 1 -yl)carbonyl]propyl } -
2,4-dimethylbenzenesulfonamide
Figure imgf000015_0004
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
14 methylpiperidin- 1 -yl)carbonyl]propyl } -
2,5-dimethylbenzenesulfonamide
Figure imgf000015_0005
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
15 methylpiperidin- 1 -yl)carbonyl]propyl } -
3 , 5 -dimethylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
16 methylpiperidin- 1 -yl)carbonyl]propyl } -
2-methoxybenzenesulfonamide
Figure imgf000016_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
17 methylpiperidin- 1 -yl)carbonyl]propyl } -
3-methoxybenzenesulfonamide
Figure imgf000016_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
18 methylpiperidin- 1 -yl)carbonyl]propyl } -
4-methoxybenzenesulfonamide
N- [ 1 - { [4- (hydroxymethyl)piperidin- 1 -
19 yl]carbonyl}-3-(lH-pyrazol-l- yl)propyl] - 1 H-indole-4-sulfonamide
Figure imgf000016_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
1,3,5 -trimethyl- 1 H-pyrazole-4- sulfonamide
Figure imgf000016_0004
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } - 4-fluoro-2-methylbenzenesulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl } benzenesulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl } benzenesulfonamide
Figure imgf000017_0001
4-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl } benzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2,5-dimethylthiophene-3-sulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl} pyridine-3-
Figure imgf000017_0002
sulfonamide Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } - 2,4-dimethyl- 1 , 3 -thiazole- 5 -sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole- 3 - sulfonamide
2-cyano-N- { 3-(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-5- methylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-4-sulfonamide
Figure imgf000018_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
31 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole- 6- sulfonamide
Figure imgf000018_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
32 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 -benzofuran-7-sulfonamide
Figure imgf000018_0003
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
33 methylpiperidin- 1 -yl)carbonyl]propyl } - lH-indazole-4-sulfonamide
Figure imgf000019_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
34 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indazole- 6- sulfonamide
Figure imgf000019_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
35 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole- 5 - sulfonamide
N-{3-(3-cyano-lH-pyrazol-l-yl)-l-[(4-
36 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-4-sulfonamide
N-{3-(5-cyano-lH-pyrazol-l-yl)-l-[(4-
37 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-4-sulfonamide
Figure imgf000019_0003
3-acetyl-N-{3-(2-cyano-lH-pyrrol-l-
38 yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
Figure imgf000019_0004
Example Structure Name
4-acetyl-N-{3-(2-cyano-lH-pyrrol-l-
39 yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
40 methylpiperidin- 1 -yl)carbonyl]propyl } -
2,4,6-trimethylbenzenesulfonamide
Figure imgf000020_0001
3-amino-N-{3-(2-cyano-lH-pyrrol-l- yl)- 1 -[(4-methylpiperidin- 1 - yl)carbonyl]propyl}-2,4-
Figure imgf000020_0002
dimethylbenzenesulfonamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4- (hydroxymethyl)piperidin-l-
42 yl]carbonyl}propyl]-2,5- dimethylbenzenesulfonamide
Figure imgf000020_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2-methoxy-4- methylbenzenesulfonamide
Figure imgf000020_0004
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2-methoxy-5- methylbenzenesulfonamide
Figure imgf000020_0005
Example Structure Name
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-6- methylbenzenesulfonamide
Figure imgf000021_0001
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -2- methylbenzenesulfonamide
Figure imgf000021_0002
N-{3-(5-chloro-lH-pyrazol-l-yl)-l-[(4-
47 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-4-sulfonamide
Figure imgf000021_0003
N-{3-(5-chloro-lH-pyrazol-l-yl)-l-[(4-
48 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-6-sulfonamide
Figure imgf000021_0004
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 - yl)carbonyl]propyl } naphthalene- 1 - sulfonamide
Figure imgf000021_0005
N-benzyl-4-(2-cy ano- 1 H-pyrrol- 1 -yl)-2-
50 { [(2,5-dimethylphenyl)sulfonyl] amino } -
N-methylbutanamide
Figure imgf000021_0006
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
51 methylpiperidin- 1 -yl)carbonyl]propyl } isoquinoline- 5 - sulfonamide
Figure imgf000022_0001
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -A- fluorobenzenesulfonamide
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } - 1 ,3-dimethyl- IH- pyrazole-4-sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
1 -methyl- 1 H-indole-4-sulfonamide
Figure imgf000022_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
55 methylpiperidin- 1 -yl)carbonyl]propyl } -
7-methyl- 1 H-indole-4-sulfonamide
Figure imgf000022_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
56 methylpiperidin- 1 -yl)carbonyl]propyl } -
2-oxoindoline- 5 - sulfonamide
Figure imgf000022_0004
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
57 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 -benzothiophene-3 -sulfonamide
Figure imgf000023_0001
N-[3-(5-cyano-lH-pyrazol-l-yl)-l-{ [4-
(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
Figure imgf000023_0002
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4- (hydroxy methyl)piperidin- 1 - yl] carbonyl } propyl] - 1 H-indazole-4-
Figure imgf000023_0003
sulfonamide
N-{3-[({3-(2-cyano-lH-pyrrol-l-yl)-l-
[(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl]phenyl } acetamide
Figure imgf000023_0004
N-{4-[({3-(2-cyano-lH-pyrrol-l-yl)-l-
[(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl]phenyl } acetamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2, 1 ,3-benzothiadiazole-4-sulfonamide
Figure imgf000023_0005
Example Structure Name
2-chloro-N- { 3 -(5 -chloro- 1 H-pyrazol- 1 - yl)- 1 -[(4-methylpiperidin- 1 - yl)carbonyl]propyl}-6- methylbenzenesulfonamide
1 - { 3 - [( 1 H-indol-4-ylsulfonyl)amino] -A-
(4-methylpiperidin- 1 -yl)-4-oxobutyl } -
1 H-pyrazole-5-carboxamide
Figure imgf000024_0001
Figure imgf000024_0002
methyl 2-[({3-(2-cyano-lH-pyrrol-l-yl)-
1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino)sulfonyl]ben zoate
Figure imgf000024_0003
methyl 4-[({3-(2-cyano-lH-pyrrol-l-yl)-
67 1 - [(4-methylpiperidin- 1 -yl)carbonyl] propyl } amino)sulfonyl]benzoate
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
68 methylpiperidin- 1 -yl)carbonyl]propyl } - 5-ethyl-2-methoxybenzenesulfonamide
Figure imgf000024_0004
Example Structure Name
2-chloro-4-cyano-N- { 3 -(2-cyano- 1 H- pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } benzenesulfonamide
4-amino-3,5-dichloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(l H- pyrazol-1- yl)propyl } benzenesulfonamide
2-amino-4, 6-dichloro-N- { 1 - [(4-methyl piperidin-l-yl)carbonyl]-3-(2H-l,2,3- triazol-2-yl)propyl}benzenesulfonamide
4-amino-3,5-dichloro-N-{ l-[(4-methyl piperidin-l-yl)carbonyl]-3-(2H-l,2,3- triazol-2-yl)propyl}benzenesulfonamide
N- { 1 - [(4-methylpiperidin- 1 - yl)carbonyl]-3-(2-nitro-lH-imidazol-l- yl)propyl } - 1 H-indole-4-sulfonamide
N- { 1 - [(4-methylpiperidin- 1 - yl)carbonyl]-3-(2-nitro-lH-imidazol-l- yl)propyl } - 1 H-indole-6-sulfonamide
Figure imgf000025_0001
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2 , 5 -dimethoxybenzenesulf onamide
N-benzyl-4-(2-cy ano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4-ylsulfonyl)amino]-N- methylbutanamide
2-chloro-N- [3-(2-cyano- lH-pyrrol- 1 - yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 - yl]carbonyl} propyl] -6- methylbenzenesulfonamide
Figure imgf000026_0001
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -2- methoxybenzenesulfonamide
3 -amino-2,4-dimethyl-N- { 1 - [(4-methyl piperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H- imidazol-1-
Figure imgf000026_0002
yl)propyl } benzenesulf onamide
Chiral
4-(2-cyano-lH-pyrrol-l-yl)-2-{ [(2,5- dimethylphenyl) sulf onyl] amino } -N- methyl-N-[(lR)-l- phenylethyl] butanamide
Figure imgf000026_0003
Example Structure Name
} -
- { [4- 1 -
Figure imgf000027_0001
N- { 1 - [(4-methylpiperidin- 1 - yl)carbonyl]-3-(2H-l,2,3-triazol-2- yl)propyl}-2,4- dinitrobenzenesulfonamide
2,3-dichloro-N-{3-(2-cyano-lH-pyrrol-
1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } benzenesulfonamide
Figure imgf000027_0002
2,5-dichloro-N-{3-(2-cyano-lH-pyrrol-
1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } benzenesulfonamide
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-
1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } benzenesulfonamide
Figure imgf000027_0003
Example Structure Name
3,5-dichloro-N-{3-(2-cyano-lH-pyrrol-
1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } benzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } - 2-(trifluoromethyl)benzenesulfonamide
Figure imgf000028_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
89 methylpiperidin- 1 -yl)carbonyl]propyl } - 3-(trifluoromethyl)benzenesulfonamide
Figure imgf000028_0002
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-2(lH)- ylcarbonyl] propyl } -2 , 5 - dimethylbenzenesulfonamide
Figure imgf000028_0003
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-4,5- difluorobenzenesulfonamide
N-benzyl-2- { [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000028_0004
Example Structure Name
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -3-methyl- 1 - benzothiophene-2-sulfonamide
N-{4-[({3-(2-cyano-lH-pyrrol-l-yl)-l-
[(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl] -3- methylphenyl } acetamide
methyl l-{3-[(lH-indol-4- ylsulfonyl)amino]-4-(4-methylpiperidin-
1 -yl)-4-oxobutyl } - 1 H-pyrrole-2-
Figure imgf000029_0001
carboxylate
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
1 -methyl-3-(trifluoromethyl)- 1 H- pyrazole-4-sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
4-methoxy-2,3,6- trimethylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
5-methyl-2, 1 ,3-benzothiadiazole-4- sulfonamide
Figure imgf000029_0002
Example Structure Name
2,5-dichloro-N-{3-(2-cyano-lH-pyrrol-
1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl } thiophene- 3 - sulfonamide
N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 -
[(4-methylpiperidin- 1 - yl)carbonyl]propyl } -A- methylnaphthalene- 1 -sulfonamide
Figure imgf000030_0001
2-bromo-N-[3-(2-cyano-l H-pyrrol- 1-
101 yl)- 1 -(piperidin- 1 -ylcarbonyl)propyl]-6- methylbenzenesulfonamide
Figure imgf000030_0002
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl } benzenesulfonamide
Figure imgf000030_0003
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
[(trans)-octahydroisoquinolin-2(lH)- ylcarbonyl] propyl} -lH-indole-4- sulfonamide
Figure imgf000030_0004
6-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl} imidazo[2,l- b] [ 1 , 3 ] thiazole- 5 - sulfonamide
Figure imgf000030_0005
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
5 -methyl-3 -phenylisoxazole-4- sulfonamide
2,4-dichloro-N-{3-(2-cyano-lH-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-5- methylbenzenesulfonamide
2,4-dichloro-N-{3-(2-cyano-lH-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-6- methylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2 , 5 , 6-trimethyl- 1 H-benzimidazole-7 - sulfonamide
Figure imgf000031_0001
Figure imgf000031_0002
Example Structure Name
Figure imgf000032_0001
4-chloro-2,5-dimethyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
4-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)c arbonyl] propyl } thiophene- 3 -
Figure imgf000032_0002
sulfonamide
2,6-dichloro-N-[3-(2-cyano-lH-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
4-amino-3,5-dichloro-N-{3-(2-cyano- 1 H-imidazol- l-yl)-l- [(4- methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
Figure imgf000032_0003
Figure imgf000032_0004
Example Structure Name
4-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } naphthalene- 1 - sulfonamide
N-(4-chlorobenzyl)-4-(2-cyano-lH- pyrrol-l-yl)-2-{ [(2,5- dimethylphenyl) sulf onyl] amino } -N- methylbutanamide
Figure imgf000033_0001
} -
Figure imgf000033_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
4-fluoro-2- (trifluoromethyl)benzenesulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(trans)-octahydroisoquinolin-
2(lH)-ylcarbonyl]propyl}-6- methylbenzenesulfonamide
Figure imgf000033_0003
methyl 3-[({3-(2-cyano-lH-pyrrol-l-yl>
1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino)sulfonyl] -A- methoxybenzoate
Figure imgf000033_0004
Example Structure Name
N-benzyl-4-(2-cy ano- 1 H-pyrrol- 1 -yl)-2-
{ [(2,6-dichlorophenyl)sulfonyl]amino } -
N-methylbutanamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
[(trans)-octahydroisoquinolin-2(lH)- ylcarbonyl] propyl } naphthalene- 1 - sulfonamide
Figure imgf000034_0001
N- { 2-chloro-4- [( { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl] propyl } amino) sulfonyl] phenyl } acetamid
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -6- methylbenzenesulfonamide
Figure imgf000034_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
3-(2-methylpyrimidin-4- yl)benzenesulfonamide
Figure imgf000034_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
128 methylpiperidin- 1 -yl)carbonyl]propyl } -
4-phenoxybenzenesulfonamide
Figure imgf000034_0004
Example Structure Name
4-amino-3,5-dichloro-N-{3-(2-chloro- lH-imidazol-l-yl)-l-[(4- methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
N- { 3 -(5-bromo- 1 H-pyrazol- 1 -yl> 1 - [(4- methylpiperidin- 1 -yl)carbonyl]propyl } - lH-indole-4-sulfonamide
Figure imgf000035_0001
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -A- fluorobenzenesulfonamide
2-acetyl-N- {3-(2-cyano-l H-pyrrol- 1- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-l,2,3,4- tetrahydroisoquinoline-7-sulfonamide
Figure imgf000035_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
4-(2-methyl-l ,3-thiazol-4- yl)benzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2-methoxy-5- (trifluoromethyl)benzenesulfonamide
Figure imgf000035_0003
Example Structure Name
2-bromo-N- { 1 - [(4-methylpiperidin- 1 -
135 yl)carbonyl]-3-(2-nitro-lH-imidazol-l- yl)propyl } benzenesulf onamide
Figure imgf000036_0001
2-amino-4,6-dichloro-N-{ l-[(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]-3-(2H-l,2,3-triazol-2- yl)propyl} benzenesulf onamide
2,4,6-trichloro-N-{3-(2-cyano-lH- pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
2,4-dichloro-6-methyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulf onamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(2- methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-4-sulf onamide
Figure imgf000036_0002
Chiral
4-(2-cyano-lH-pyrrol-l-yl)-2-{ [(2,6- dichlorophenyl)sulfonyl] amino } -N- methyl-N- [(I R)-I- phenylethyl] butanamide
Figure imgf000036_0003
Example Structure Name
4-amino-3,5-dichloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
N-(4-chlorobenzyl)-2- { [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- lH-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000037_0001
Figure imgf000037_0002
5-bromo-N-{3-(2-cyano-lH-pyrrol-l- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl J -2- methoxybenzenesulfonamide
N- [3-(2-chloro- lH-imidazol- 1 -yl)- 1 - (3,4-dihydroisoquinolin-2(lH)- ylcarbonyl)propyl] -A- methylnaphthalene- 1 -sulfonamide
Figure imgf000037_0003
4-amino-3,5-dichloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(l H- pyrrolo [2 , 3 -b] pyridin- 1 - yl)propyl Jbenzenesulfonamide
Figure imgf000037_0004
Example Structure Name
N-[3-(5-bromo-lH-pyrazol-l-yl)-l-{ [4-
(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
Figure imgf000038_0001
4-({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -
148 yl)carbonyl]propyl } sulfamoyl)-N,N-
Figure imgf000038_0002
dimethyl-lH-indole-2-carboxamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-phenylpiperazin- 1 -
149 yl)carbonyl]propyl}-6- methylbenzenesulfonamide
2,4,6-trichloro-N-{3-(2-chloro-lH-
150 imidazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
2-bromo-6-methyl-N-{ l-[(4- methylpiperidin-l-yl)carbonyl]-3-(2-
151 nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
Figure imgf000038_0003
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-4,6- difluorobenzenesulfonamide
Figure imgf000038_0004
Example Structure Name
N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-2(lH)- ylcarbonyl]propyl } -A- methylnaphthalene- 1 -sulfonamide
N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-2(lH)- ylcarbonyl]propyl } -A- methylnaphthalene- 1 -sulfonamide
Figure imgf000039_0001
2,4,6-trichloro-N-[3-(2-cyano-lH- pyrrol-l-yl)-l-{ [4-
(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
2,6-dichloro-N-[3-(2-chloro-lH- imidazol-l-yl)-l-(3,4- dihydroisoquinolin-2(lH)- ylcarbonyl)propyl]benzenesulfonamide
2,6-dichloro-N-{3-(2-chloro-lH- imidazol- 1 -yl)- 1 - [(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
2,6-dichloro-N-{3-(2-chloro-lH- imidazol-l-yl)-l-[(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
Figure imgf000039_0002
Example Structure Name
2-{ [(4-amino-3,5-dichlorophenyl) sulfonyl] amino } -4-(2-cy ano- 1 H-pyrrol-
1 -yl)-N-methyl-N- [( 1 R)- 1 - phenylethyl] butanamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(hydroxymethyl)piperidin- 1 - yl] carbonyl } propyl] - 1 H-indole-6- sulfonamide
N- [ 1 -(3 ,4-dihydroisoquinolin-2( 1 H)- ylcarbonyl)-3-(2-nitro- 1 H-imidazol- 1 - yl)propyl] -4-methylnaphthalene- 1 - sulfonamide
Figure imgf000040_0001
5-bromo-N-{3-(2-cyano-lH-pyrrol-l- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -2,3-dihydro- 1 - benzofuran-7-sulfonamide
2,6-dichloro-N-[l-(3,4- dihydroisoquinolin-2(lH)-ylcarbonyl)-
3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl] benzenesulf onamide
N-(4-chlorobenzyl)-4-(2-cyano-lH- pyrrol-l-yl)-2-{ [(2,6- dichlorophenyl) sulfonyl] amino } -N- methylbutanamide
Figure imgf000040_0002
Example Structure Name l-l-yl)- Jbutana
Figure imgf000041_0001
4-methyl-N- { 3 -(2-nitro- 1 H-imidazol- 1 - yl)-l-[(cis)-octahydroisoquinolin-2(lH)- ylcarbonyl] propyl } naphthalene- 1 - sulfonamide
4-methyl-N- { 3 -(2-nitro- 1 H-imidazol- 1 - yl)- 1 -[(trans)-octahydroisoquinolin-
2(lH)-ylcarbonyl]propyl}naphthalene-
1- sulfonamide
2-amino-4,6-dichloro-N-[3-(2-chloro- lH-imidazol-l-yl)-l-(3,4- dihydroisoquinolin-2(lH)- ylcarbonyl)propyl]benzenesulfonamide
4-amino-3,5-dichloro-N-[3-(2-chloro- lH-imidazol-l-yl)-l-(3,4- dihydroisoquinolin-2(lH)- ylcarbonyl)propyl]benzenesulfonamide
2,6-dichloro-N-{3-(2-nitro-lH- imidazol- 1 -yl)- 1 - [(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
Figure imgf000041_0002
Example Structure Name
2,6-dichloro-N-{3-(2-nitro-lH- imidazol- 1 -yl)- 1 - [(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
2-bromo-N-[3-(2-cyano-lH-pyrrol-l- yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]-4,6- difluorobenzenesulfonamide
2-amino-4,6-dichloro-N-{3-(2-chloro-
1 H-imidazol- 1 -yl)- 1 - [(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
2-amino-4,6-dichloro-N-{3-(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
4-amino-3,5-dichloro-N-{3-(2-chloro-
1 H-imidazol- 1 -yl)- 1 - [(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
4-amino-3,5-dichloro-N-{3-(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
Figure imgf000042_0001
Example Structure Name
N-benzyl-2-{ [(2-bromo-4,6- difluorophenyl)sulfonyl] amino } -4-(2- cyano- lH-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000043_0001
} -
-
Figure imgf000043_0002
2-amino-4,6-dichloro-N-[l-(3,4- dihydroisoquinolin-2(lH)-ylcarbonyl)-
3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl] benzenesulf onamide
2-{ [(4-amino-3,5- dichlorophenyl)sulfonyl]amino}-N-(4- chlorobenzyl)-4-(2-cyano-lH-pyrrol-l- yl)-N-methylbutanamide
2,4,6-trichloro-N-{3-(2-cyano-lH- pyrrol- 1 -yl)- 1 -[(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
Figure imgf000043_0003
Example Structure Name
2-amino-4,6-dichloro-N- { 3-(2-nitro- 1 H- imidazol- 1 -yl)- 1 - [(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
2-amino-4,6-dichloro-N- { 3-(2-nitro- 1 H- imidazol- 1 -yl)- 1 - [(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-5- (trifluoromethyl)benzenesulfonamide
2-amino-4,6-dichloro-N-[3-(2-chloro- lH-imidazol-l-yl)-l-{ [4-
(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
Figure imgf000044_0001
Chiral
2-{ [(2-bromo-4,6- difluorophenyl)sulfonyl]amino}-4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-
[(lR)-l-phenylethyl]butanamide
4-bromo-2,5-dichloro-N-{3-(2-cyano-
1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- l-yl)carbonyl]propyl}thiophene-3- sulfonamide
Figure imgf000044_0002
Example Structure Name
2,4,6-trichloro-N-{3-(2-chloro-lH- imidazol- 1 -yl)- 1 - [(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
2,4,6-trichloro-N-{3-(2-chloro-lH- imidazol- 1 -yl)- 1 - [(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
tert-butyl 3- [( { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl] -2- methyl- 1 H-indole- 1 -carboxylate
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 -[(trans)-octahydroisoquinolin-
2(lH)-ylcarbonyl]propyl}-4,6- difluorobenzenesulfonamide
2,4,6-trichloro-N-[l-(3,4- dihydroisoquinolin-2(lH)-ylcarbonyl)-
3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl] benzenesulf onamide
2-amino-4,6-dichloro-N-[3-(2-nitro-lH- imidazol-l-yl)-l-{ [4-
(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
Figure imgf000045_0001
Example Structure Name
2,4,6-trichloro-N-{3-(2-nitro-lH- imidazol- 1 -yl)- 1 - [(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
2,4,6-trichloro-N-{3-(2-nitro-lH- imidazol-l-yl)-l-[(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
4-bromo-2,6-dichloro-N-{ l-[(4- methylpiperidin-l-yl)carbonyl]-3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
2-{ [(2-bromo-4,6- difluorophenyl)sulfonyl] amino } -N-(4- chlorobenzyl)-4-(2-cyano-lH-pyrrol-l- yl)-N-methylbutanamide
Figure imgf000046_0001
Figure imgf000046_0002
5-chloro-6-[3-(2-cyano-pyrrol-l-yl)-l-
(4-methyl-piperidine- 1 -carbonyl)- propylsulf amoyl] -indole- 1 -carboxylic acid tert-butyl ester
Figure imgf000046_0003
Example Structure Name
4-amino-3,5-dibromo-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propylJ-lH-indazole-5- sulfonamide
Figure imgf000047_0001
Figure imgf000047_0002
2-amino-4,6-dichloro-N-{3-(2-chloro- lH-imidazol-l-yl)-l-[(4- methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
2-amino-4,6-dichloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
Figure imgf000047_0003
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } - lH-pyrrolo[2,3-b]pyridine-4- sulfonamide
3-bromo-N-{3-(2-cyano-lH-pyrrol-l- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-pyrrolo[2,3- b]pyridine-4-sulfonamide
2,6-dichloro-N-{3-(2-chloro-lH- imidazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
2,6-dichloro-N-{ l-[(4-methylpiperidin-
1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol-
1 -yl)propyl } benzenesulfonamide
2,5-dimethoxy-N-{ l-[(4- methylpiperidin-l-yl)carbonyl]-3-(2- nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulfonamide
2-methoxy-4-methyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 -
Figure imgf000048_0001
yl)propyl } benzenesulfonamide Example Structure Name
N- { 1 - [(4-methylpiperidin- 1 - yl)carbonyl]-3-(2-nitro-l H-imidazol- 1- yl)propyl } naphthalene- 1 -sulfonamide
2,3,4-trichloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
2,3-dichloro-N-{ l-[(4-methylpiperidin-
1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol-
1 -yl)propyl } benzenesulfonamide
2,4,6-trichloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2 nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
2,4,6-trimethyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
2,4-dichloro-5-methyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
Figure imgf000049_0001
Example Structure Name
2-Trifluoromethyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
2-chloro-6-methyl-N- { 1 - [(4- methylpiperidin-l-yl)carbonyl]-3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
2-methoxy-5-methyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
3-bromo-5-chloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(2- nitro- 1 H-imidazol- 1 - yl)propyl J thiophene-2-sulfonamide
3-chloro-2-methyl-N-{ l-[(4- methylpiperidin-l-yl)carbonyl]-3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
4-bromo-2,5-dichloro-N-{ l-[(4- methylpiperidin-l-yl)carbonyl]-3-(2- nitro- 1 H-imidazol- 1 - yl)propyl J thiophene- 3 - sulfonamide
Figure imgf000050_0001
Example Structure Name
4-methoxy-2,3,6-trimethyl-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3 -(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
4-methyl-N- { 1 -[(4-methylpiperidin- 1 - yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl } naphthalene- 1 -sulfonamide
5-bromo-2-methoxy-N-{ l-[(4- methylpiperidin-l-yl)carbonyl]-3-(2- nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
4-amino-3,5-dichloro-N-{ l-[(4- methylpiperidin- 1 -yl)carbonyl] -3-(l H- pyrrol- 1 -yl)propyl } benzenesulfonamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
(morpholin-4-ylcarbonyl)propyl]-lH- indole-4-sulfonamide
Figure imgf000051_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methyl- 3 , 6-dihydropyridin- 1 (2H) - yl)carbonyl]propyl } - 1 H-indole-4-
Figure imgf000051_0002
sulfonamide Example Structure Name
N-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-
238 1 H-pyrrol- 1 -yl)propyl] - 1 H- indoles- sulfonamide
Figure imgf000052_0001
N-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-
239 1 H-pyrrol- 1 -yl)propyl] - 1 H-indole-6- sulfonamide
Figure imgf000052_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(2-
241 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole- 6- sulfonamide
Figure imgf000052_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-
242 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-4-sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-
243 methylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole- 6- sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
244 oxopiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
Figure imgf000052_0004
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
245 methylpiperazin- 1 -yl)carbonyl]propyl } - lH-indole-4-sulfonamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(l,4-
246 oxazepan-4-ylcarbonyl)propyl] - 1 H- indole-4-sulfonamide
Figure imgf000053_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3- hydroxypiperidin- 1 - yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
Figure imgf000053_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- hydroxypiperidin- 1 - yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- fluoropiperidin- 1 -yl)carbonyl]propyl } - lH-indole-4-sulfonamide
Figure imgf000053_0003
N-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-
250 lH-pyrrol-l-yl)propyl]-2-chloro-6- methylbenzenesulfonamide
Figure imgf000053_0004
Example Structure Name
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(2-methylpiperidin- 1 - yl)carbonyl]propyl}-6- methylbenzenesulfonamide
Figure imgf000054_0001
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(3 -methylpiperidin- 1 - yl)carbonyl]propyl}-6- methylbenzenesulfonamide
Figure imgf000054_0002
N- [ 1 -(6-azaspiro [2.5] oct-6-ylcarbonyl)-
253 3-(2-cyano-lH-pyrrol-l-yl)propyl]-lH- indole-4-sulfonamide
Figure imgf000054_0003
N- [ 1 -(6-azaspiro [2.5] oct-6-ylcarbonyl)-
254 3-(2-cyano-lH-pyrrol-l-yl)propyl]-lH- indole- 6- sulfonamide
Figure imgf000054_0004
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methyl- 1 ,4-diazepan- 1 - yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
Figure imgf000054_0005
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(5- oxo- 1 ,4-diazepan- 1 - yl)carbonyl]propyl } - 1 H-indole-4-
Figure imgf000054_0006
sulfonamide Example Structure Name
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [2-
(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{ [3-
(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
N- [ 1 -(6-azaspiro [2.5] oct-6-ylcarbonyl)- 3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl] -2- chloro-6-methylbenzenesulfonamide
Figure imgf000055_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
262 propylpiperidin- 1 -yl)carbonyl]propyl } - lH-indole-4-sulfonamide
Figure imgf000055_0002
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-cyclohexyl-N- methylbutanamide
Figure imgf000055_0003
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
264 propylpiperidin- 1 -yl)carbonyl]propyl } - lH-indole-6-sulfonamide
Figure imgf000056_0001
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-
265 l-yl)-l-[(3 -methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
N-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-
266 lH-pyrrol- 1 -yl)propyl] -2,6- dichlorobenzenesulfonamide
N- { l-[(4-acetylpiperazin-l-
267 yl)carbonyl] -3-(2-cyano- lH-pyrrol- 1 - yl)propyl}-lH-indole-4-sulfonamide
Figure imgf000056_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4,4- difluoropiperidin- 1 - yl)carbonyl]propyl}-lH-indole-4- sulfonamide
Figure imgf000056_0003
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(2-hydroxyethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
Figure imgf000056_0004
Example Structure Name
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(methoxymethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(2-hydroxyethyl)piperazin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
Figure imgf000057_0001
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-
(pyridin-2-ylmethyl)butanamide
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-
(pyridin- 3 -ylmethyl)butanamide
Figure imgf000057_0003
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4- dihydroisoquinolin-2(lH)- ylcarbonyl)propyl] - 1 H-indole-4- sulfonamide
Figure imgf000057_0004
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4- dihydroisoquinolin-2(lH)- ylcarbonyl)propyl] - 1 H-indole-6- sulfonamide
Figure imgf000057_0005
Example Structure Name
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-propylpiperidin- 1 - yl)carbonyl]propyl } -6- methylbenzenesulfonamide
Figure imgf000058_0001
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3- methyl-5,6-dihydro[l,2,4]triazolo[4,3- a]pyrazin-7(8H)-ylcarbonyl)propyl]-lH- indole-4-sulfonamide
Figure imgf000058_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl } - 1 H-indole-4- sulfonamide
Figure imgf000058_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl } - 1 H-indole-6- sulfonamide
Figure imgf000058_0004
N- [ 1 -(6-azaspiro [2.5] oct-6-ylcarbonyl)-
3-(2-cyano-lH-pyrrol-l-yl)propyl]-2,6- dichlorobenzenesulfonamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
(octahydro-2H-pyrido[l,2-a]pyrazin-2- ylcarbonyl)propyl]-lH-indole-4- sulfonamide
Figure imgf000058_0005
Example Structure Name
2-chloro-N- [3-(2-cyano- lH-pyrrol- 1 - yl)-l-(3,4-dihydroisoquinolin-2(lH)- ylcarbonyl)propyl] -6- methylbenzenesulfonamide
Figure imgf000059_0001
N- { 1 - [(4-acetyl- 1 ,4-diazepan- 1 -
283 yl)carbonyl] -3 -(2-cyano- 1 H-pyrrol- 1 - yl)propyl } - 1 H-indole-4-sulfonamide
Figure imgf000059_0002
Figure imgf000059_0003
4-amino-N-[l-(azepan-l-ylcarbonyl)-3-
286 (2-cyano-lH-pyrrol-l-yl)propyl]-3,5- dichlorobenzenesulfonamide
methyl 1 - { 4-(2-cyano- lH-pyrrol- 1 -yl)-
2-[(lH-indol-4-
287 ylsulfonyl)amino]butanoyl}piperidine- 4-carboxylate
Figure imgf000059_0004
Example Structure Name
methyl 1 - { 4-(2-cyano- lH-pyrrol- 1 -yl)-
2-[(lH-indol-6- ylsulfonyl)amino]butanoyl}piperidine- 4-carboxylate
Figure imgf000060_0001
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(l,4- dioxa-8-azaspiro[4.5]dec-8- ylcarbonyl)propyl] - 1 H-indole-4- sulfonamide
Figure imgf000060_0002
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
( 1 -hydroxy- 1 -methylethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
Figure imgf000060_0003
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2-
291 cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(3- methylbenzyl)butanamide
Figure imgf000060_0004
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(4- methylbenzyl)butanamide
Figure imgf000060_0005
Chiral
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-
Figure imgf000060_0006
[( 1 S)- 1 -phenylethyl]butanamide Example Structure Name
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- lH-pyrrol- 1 -yl)-N-(2- fluorobenzyl)-N-methylbutanamide
Figure imgf000061_0001
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-(3 - fluorobenzyl)-N-methylbutanamide
Figure imgf000061_0002
-4-(2- de
Figure imgf000061_0003
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(cis)-octahydroisoquinolin-2( 1 H)- ylcarbonyl]propyl } -6- methylbenzenesulfonamide
Figure imgf000061_0004
methyl 1 -[2- { [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 - yl)butanoyl]piperidine-4-carboxylate
Figure imgf000061_0005
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-4- sulfonamide
Figure imgf000061_0006
Example Structure Name
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]-lH-indole-6- sulfonamide
Figure imgf000062_0001
4-amino-N-[l-(6-azaspiro[2.5]oct-6- ylcarbonyl)-3-(2-cyano-lH-pyrrol-l- yl)propyl]-3,5- dichlorobenzenesulfonamide
Figure imgf000062_0002
1 -yl>
Figure imgf000062_0003
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-
1 -yl)- 1 - [(4-propylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
3 -( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-4- yl)propanamide
Figure imgf000062_0004
methyl ( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl>
2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-2- yl) acetate
Figure imgf000062_0005
Example Structure Name
methyl ( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl>
2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-3- yl) acetate
Figure imgf000063_0001
methyl ( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl>
2-[(lH-indol-4-
307 ylsulfonyl)amino]butanoyl}piperidin-4- yl) acetate
Figure imgf000063_0002
3-chloro-N- [3-(2-cyano- lH-pyrrol- 1 - yl)-l-(5,6-dihydro[l,2,4]triazolo[4,3- a]pyrazin-7(8H)-ylcarbonyl)propyl]-lH-
Figure imgf000063_0003
indole-4-sulfonamide
4-amino-3,5-dichloro-N-[3-(2-cyano- lH-pyrrol-l-yl)-l-{ [4-
(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-(2- methoxybenzyl)-N-methylbutanamide
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-(3 - methoxybenzyl)-N-methylbutanamide
Figure imgf000063_0005
Example Structure Name
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- lH-pyrrol- 1 -yl)-N-(4- methoxybenzyl)-N-methylbutanamide
Figure imgf000064_0001
2,6-dichloro-N-[3-(2-cyano-lH-pyrrol- l-yl)-l-(3,4-dihydroisoquinolin-2(lH)- ylcarbonyl)propyl]benzenesulfonamide
2-chloro-N- [3-(2-cyano- lH-pyrrol- 1 - yl)- 1 - { [4-(trifluoromethyl)piperidin- 1 - yl]carbonyl} propyl] -6- methylbenzenesulfonamide
Figure imgf000064_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
315 phenylpiperazin- 1 -yl)carbonyl]propyl } - lH-indole-4-sulfonamide
Figure imgf000064_0003
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(methylsulfonyl)piperidin- 1 - yl] carbonyl } propyl] - 1 H-indole-4-
Figure imgf000064_0004
sulfonamide
N-(2-chlorobenzyl)-2- { [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000064_0005
Example Structure Name
N-(3-chlorobenzyl)-2- { [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- lH-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000065_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- pyrimidin-2-ylpiperazin- 1 - yl)carbonyl]propyl}-lH-indole-4- sulfonamide
Figure imgf000065_0002
Figure imgf000065_0003
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
( 1 , 3-thiazol-2-yl)piperazin- 1 - yl] carbonyl } propyl] - 1 H-indole-4- sulfonamide
Figure imgf000065_0004
methyl (2E)-3-(l-{4-(2-cyano-lH- pyrrol- 1 -yl)-2- [( 1 H-indol-4- ylsulf onyl) amino] butanoyl } piperidin- 3 - yl)prop-2-enoate
Figure imgf000065_0005
N- [2-( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-2- yl)ethyl] acetamide
Figure imgf000065_0006
Example Structure Name
N-[2-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2- [(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-4- yl)ethyl] acetamide
Figure imgf000066_0001
4-amino-3,5-dichloro-N-{3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-propylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
methyl 3 -( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 - yl)-2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-3-
Figure imgf000066_0002
yl)propanoate
methyl 3 -( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 - yl)-2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-4- yl)propanoate
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6- dihydro [1,2,4] triazolo [4, 3 - a] pyrazin-
7(8H)-ylcarbonyl)propyl]-lH-indole-4-
Figure imgf000066_0003
sulfonamide
-yl)-
Figure imgf000066_0004
Example Structure Name
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano-lH-pyrrol-l-yl)-N-(2-methoxy-5- methylbenzyl)-N-methylbutanamide
Figure imgf000067_0001
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(2- naphthylmethyl)butanamide
Figure imgf000067_0002
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(l -
Figure imgf000067_0003
naphthylmethyl)butanamide
2,6-dichloro-N-[3-(2-cyano-lH-pyrrol-
333 1 -yl)- 1 - { [4-(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
methyl 4-( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 - yl)-2-[(lH-indol-4-
334 ylsulfonyl)amino]butanoyl}piperidin-4-
Figure imgf000067_0004
yl)butanoate
methyl 4-( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 - yl)-2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-3- yl)butanoate
Figure imgf000067_0005
Example Structure Name
l-[2-{ [(4-amino-3,5- dichlorophenyl)sulfonyl] amino }-4-(2- cyano- 1 H-pyrrol- 1 -yl)butanoyl] -N- methylpiperidine-4-carboxamide
methyl l-[2-{ [(4-amino-3,5- dichlorophenyl)sulfonyl]amino}-4-(2- cyano- 1 H-pyrrol- 1 - yl)butanoyl]piperidine-4-carboxylate
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-(3 ,4-
Figure imgf000068_0001
dimethoxybenzyl)-N-methylbutanamide
N- { 1 - [(4-benzyl- 1 ,4-diazepan- 1 -
339 yl)carbonyl] -3 -(2-cyano- 1 H-pyrrol- 1 - yl)propyl } - 1 H-indole-4-sulfonamide
Figure imgf000068_0002
methyl 2- { 4-(2-cyano- lH-pyrrol- 1 -yl)-
2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}-l,2,3,4- tetrahydroisoquinoline-6-carboxylate
Figure imgf000068_0003
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } - l,2,3,4-tetrahydroisoquinoline-7-
Figure imgf000068_0004
carboxylic acid methyl ester Example Structure Name
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2-
342 cy ano- 1 H-pyrrol- 1 -yl)-N- [4-( 1 H- imidazol- 1 -yl)benzyl] -N-
Figure imgf000069_0001
methylbutanamide
[4-
Figure imgf000069_0002
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N- [3-
(trifluoromethyl)benzyl]butanamide
Figure imgf000069_0003
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N- [4-
(trifluoromethyl)benzyl]butanamide
Figure imgf000069_0004
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2-
346 cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N- [( 1 - methyl-l,2,3,4-tetrahydroquinolin-6-
Figure imgf000069_0005
yl)methyl] butanamide
3-[(cis)-l-{4-(2-cyano-lH-pyrrol-l-yl)-
2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}-4-
Figure imgf000069_0006
methylpiperidin-3-yl]propanoic acid Example Structure Name
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(3- pyridin-3 -ylbenzyl)butanamide
Figure imgf000070_0001
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(4- pyridin-4-ylbenzyl)butanamide
Figure imgf000070_0002
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(4-
Figure imgf000070_0003
pyrimidin-5 -ylbenzyl)butanamide
N-(2-bromobenzyl)-2- { [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000070_0004
N-(3-bromobenzyl)-2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000070_0005
N-(4-bromobenzyl)-2- { [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide
Figure imgf000070_0006
Example Structure Name
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(3- pyrimidin-5 -ylbenzyl)butanamide
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N- [3-
(5-methyl- 1 ,2,4-oxadiazol-3-
Figure imgf000071_0001
yl)benzyl] butanamide
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2-
356 cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N- [4-
(5-methyl- 1 ,2,4-oxadiazol-3-
Figure imgf000071_0002
yl)benzyl] butanamide
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(3- piperidin- 1 -ylbenzyl)butanamide
Figure imgf000071_0003
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(3- morpholin-4-ylbenzyl)butanamide
Figure imgf000071_0004
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2-
359 cyano- 1 H-pyrrol- l-yl)-N-methyl-N- [3-
(morpholin-4-
Figure imgf000071_0005
y lmethyl)benzyl] butanamide Example Structure Name
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{ [4- (3-pyrazin-2-yl-l,2,4-oxadiazol-5- l)piperidin- 1 -yl] carbonyl Jpropyl] - 1 H- indole-4-sulfonamide
ethyl 2- [(2- { 4-(2-cyano- 1 H-pyrrol- 1 ■ yl)-2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}-l, 2,3,4- tetrahydroisoquinolin-7-yl)oxy]-2-
Figure imgf000072_0001
methylpropanoate
4-amino-3,5-dichloro-N-[l-(3,4- dihydroisoquinolin-2(lH)-ylcarbonyl)-
3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl] benzenesulf onamide
4-amino-3,5-dichloro-N-[3-(2-nitro-lH- imidazol-l-yl)-l-{ [4-
(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
4-amino-3,5-dichloro-N-{ l-[(4,4- dimethylpiperidin-l-yl)carbonyl]-3-(2- nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulf onamide
4-amino-3,5-dichloro-N-{3-(2-nitro-lH- imidazol- l-yl)-l-[(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
Figure imgf000072_0002
Example Structure Name
4-amino-3,5-dichloro-N-{3-(2-nitro-lH- imidazol- 1 -yl)- 1 - [(trans)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
4-amino-3,5-dichloro-N-[l-{ [4-
(hydroxymethyl)piperidin- 1 - yl] carbonyl } -3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl]benzenesulfonamide
2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N- [2-
(trifluoromethyl)benzyl]butanamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,6- dihydropyridin- 1 (2H)- ylcarbonyl)propyl] - 1 H-indole-4-
Figure imgf000073_0001
sulfonamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
370 (piperidin- 1 -ylcarbonyl)propyl] - 1 H- indole-4-sulfonamide
Figure imgf000073_0002
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
371 (piperidin- 1 -ylcarbonyl)propyl] - 1 H- indole- 6- sulfonamide
Figure imgf000073_0003
Example Structure Name
2-chloro-N- [3-(2-cyano- lH-pyrrol- 1 -
372 yl)- 1 -(piperidin- 1 -ylcarbonyl)propyl] -6- methylbenzenesulfonamide
Figure imgf000074_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
373 oxoazepan- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
Figure imgf000074_0002
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
{ [(trans)-3-hydroxy-4-methylpiperidin-
1 -yl] carbonyl } propyl] - 1 H-indole-4-
Figure imgf000074_0003
sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(3 ,4- dimethylpiperidin- 1 - yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
Figure imgf000074_0004
N-benzyl-4-(2-cy ano- 1 H-pyrrol- 1 -yl)-2-
376 [(lH-indol-6-ylsulfonyl)amino]-N- methylbutanamide
Figure imgf000074_0005
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6- dihydro-imidazo[4,3-a]pyrazin-7(8H)- ylcarbonyl)propyl]-lH-indole-4-
Figure imgf000074_0006
sulfonamide Example Structure Name
4-amino-3,5-dichloro-N-[3-(2-cyano-
1 H-pyrrol- 1 -yl)- 1 -(piperidin- 1 - ylcarbonyl)propyl]benzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(l,l- dioxidothiomorpholin-4- yl)carbonyl]propyl}-lH-indole-4- sulfonamide
Figure imgf000075_0001
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(6,7- dihydrothieno[3,2-c]pyridin-5(4H)- ylcarbonyl)propyl]-lH-indole-4-
Figure imgf000075_0002
sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -
[(trans)-octahydroisoquinolin-2(lH)- ylcarbonyl]propyl } - 1 H-indole-6- sulfonamide
Figure imgf000075_0003
4-amino-3,5-dichloro-N-{3-(2-cyano- lH-pyrrol-l-yl)-l-[(4- methylenepiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
N-{ l-[(2-amino-6,7- dihydro[l,3]thiazolo[5,4-c]pyridin-
5(4H)-yl)carbonyl] -3 -(2-cyano- 1 H- pyrrol- 1 -yl)propyl } - 1 H-indole-4-
Figure imgf000075_0004
sulfonamide Example Structure Name
lH-indole-4-sulfonic acid [3-(2-cyano- pyrrol- 1 -yl)- 1 -(7-cyano-3 ,4-dihydro- lH-isoquinoline-2-carbonyl)-propyl]- amide
Figure imgf000076_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- phenylpiperidin- 1 -yl)carbonyl]propyl } -
1 H-indole-4-sulfonamide
2-{ [(4-amino-3,5- dichlorophenyl) sulf onyl] amino } -N- benzyl-4-(2-cyano-lH-pyrrol-l-yl)-N- methylbutanamide
ethyl l-[2-{ [(2-chloro-6- methylphenyl)sulfonyl] amino } -4-(2- cy ano- 1 H-pyrrol- 1 - yl)butanoyl]piperidine-3-carboxylate
methyl 1 -[2- { [(2-chloro-6- me thy lphenyl) sulf onyl] amino } -4-(2- cyano- 1 H-pyrrol- 1 -yl)butanoyl] -A- methylpiperidine-4-carboxylate
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(3-methyl- 1 ,2,4-oxadiazol-5- yl)piperidin- 1 -yl] carbonyl Jpropyl] - 1 H-
Figure imgf000076_0002
indole-4-sulfonamide Example Structure Name
Figure imgf000077_0001
4-amino-3,5-dichloro-N-{3-(2-cyano-
392 lH-pyrrol-l-yl)-l-[(cis)- octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}benzenesulfonamide
4-amino-3,5-dichloro-N-{3-(2-cyano- l1HH--ppyyrrrrooll--l1--yyll))--l1--[[((ttrraannss))-- ooccttaahhyyddrrooiissooqquuiinnoolliinn--22((llHH))-- ylcarbonyl]propyl}benzenesulfonamide
Figure imgf000077_0002
Figure imgf000077_0003
44--aammiinnoo--33,,55--ddiicchhlloorroo--NN--[L33--((22--cyano- lH-pyrrol-l-yl)-l-{ [4- (trifluoromethyl)piperidin- yl]carbonyl}propyl]benzenesulfonamide
Figure imgf000077_0004
Example Structure Name
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } - l,2,3,4-tetrahydroisoquinoline-7- sulfonamide
Figure imgf000078_0001
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } - l,2,3,4-tetrahydroisoquinoline-7-
Figure imgf000078_0002
sulfonic acid
Lethyl [(2- {4-(2-cyano-l H-pyrrol- 1-yl)- 2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}-l,2,3,4-
Figure imgf000078_0003
etrahydroisoquinolin-6-yl)oxy]acetate
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } -N- methyl- 1 ,2,3,4-tetrahydroisoquinoline-
Figure imgf000078_0004
7-sulfonamide
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } -
N,N-dimethyl-l, 2,3,4- tetrahydroisoquinoline-7-sulfonamide
Figure imgf000078_0005
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4- dihydroquinolin- 1 (2H)- ylcarbonyl)propyl]-lH-indole-4-
Figure imgf000078_0006
sulfonamide Example Structure Name
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } -N- methyl- 1 ,2,3,4-tetrahydroisoquinoline-
Figure imgf000079_0001
7-carboxamide
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } -
N,N-dimethyl-l, 2,3,4-
Figure imgf000079_0002
tetrahydroisoquinoline-7-carboxamide
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [7- (morpholin-4-ylcarbonyl)-3,4-
405 dihydroisoquinolin-2(lH)- yl] carbonyl } propyl] - 1 H-indole-4-
Figure imgf000079_0003
sulfonamide
4-amino-3,5-dichloro-N-{ l-[(4- methylcyclohexyl)carbonyl]-3-(2H- l,2,3-triazol-2- yl)propyl } benzenesulf onamide
4-amino-3,5-dichloro-N-{3-(2-cyano- lH-pyrrol-l-yl)-l-[(4- methylcyclohexyl)carbonyl]propyl}benz enesulfonamide
Figure imgf000079_0004
4-
408 1 -
Figure imgf000079_0005
Example Structure Name
l-acetyl-N-{3-(2-cyano-l H-pyrrol- 1- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-4- sulfonamide
tert-butyl 4- [( { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino)sulfonyl] -
Figure imgf000080_0001
lH-indole-1-carboxylate
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
411 methylpiperidin- 1 -yl)carbonyl]propyl } -
N-methyl-lH-indole-4-sulfonamide
Figure imgf000080_0002
4- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-
413 indol-4-ylsulfonyl)amino]butanoyl}-l,4- diazepane- 1 -carboxamide
Figure imgf000080_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- glycoloyl- 1 ,4-diazepan- 1 - yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- propionyl- 1 ,4-diazepan- 1 - yl)carbonyl]propyl}-lH-indole-4- sulfonamide
Figure imgf000080_0004
Example Structure Name
N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-
(methylsulfonyl)- 1 ,4-diazepan- 1 - yl] carbonyl } propyl] - 1 H-indole-4- sulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-4-(lH-tetrazol-5- yl)benzenesulfonamide
2-chloro-N- { 3-(5-cyano- 1 H-pyrazol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } -6- methylbenzenesulfonamide
Figure imgf000081_0001
Figure imgf000081_0002
3-bromo-N-{3-(2-cyano-lH-pyrrol-l- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-4-
Figure imgf000081_0003
sulfonamide
3-cyano-N- { 3-(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-4- sulfonamide
Figure imgf000081_0004
Example Structure Name
4-[({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 - yl)carbonyl]propyl } amino)sulfonyl] - lH-indole-3-carboxamide
Figure imgf000082_0001
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
2-oxoindoline-4-sulfonamide
N-{3-(3-bromo-2-cyano-lH-pyrrol-l- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-2-oxoindoline-4- sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
3-formyl- 1 H-indole-4-sulfonamide
Figure imgf000082_0002
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
3 -(hydroxymethyl)- 1 H-indole-4- sulfonamide
Figure imgf000082_0003
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
427 methylpiperidin- 1 -yl)carbonyl]propyl } - lH-indole-7-sulfonamide
Figure imgf000082_0004
Example Structure Name
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
428 methylpiperidin- 1 -yl)carbonyl]propyl } -
2-methyl- 1 H-indole- 3 - sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
429 methylpiperidin- 1 -yl)carbonyl]propyl } -
5-fluoro- lH-indole-4-sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-
430 methylpiperidin- 1 -yl)carbonyl]propyl } -
5-fluoro- lH-indole-6-sulfonamide
Figure imgf000083_0001
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-4- sulfonamide
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-6- sulfonamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6- dihydro [1,2,4] triazolo [4, 3 - a] pyrazin-
7(8H)-ylcarbonyl)propyl]-5-chloro-lH- indole-4-sulfonamide
Figure imgf000083_0002
Example Structure Name
S-chloro-lH-indole-ό-sulfonic acid [3-
(2-cyano-pyrrol- 1 -yl)- 1 -(5,6-dihydro-
8H-[l,2,4]triazolo[4,3-a]pyrazine-7- carbonyl)-propyl] -amide
4-({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 - yl)carbonyl]propyl } sulfamoyl)- 1 H- indole-7-carboxylic acid
ethyl 3-{4-[({3-(2-cyano-lH-pyrrol-l- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino)sulfonyl] -
1 H-indol-3-yl Jpropanoate
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylpiperidin- 1 -yl)carbonyl]propyl } -
5-methyl-2,3-dihydro-l-benzofuran-7- sulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-6- sulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 - yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-4-
Figure imgf000084_0001
sulfonamide Example Structure Name
3-chloro-N-{3-(5-cyano-lH-pyrazol-l- yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-lH-indole-4- sulfonamide
Figure imgf000085_0001
methyl 1 - [2- { [(3 -chloro- 1 H-indol-4- yl)sulfonyl] amino } -4-(2-cyano- 1 H- pyrrol- 1 -yl)butanoyl]piperidine-4- carboxylate
Figure imgf000085_0002
3-chloro-N- [3-(2-cyano- lH-pyrrol- 1 - yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 - yl] carbonyl } propyl] - 1 H-indole-4- sulfonamide
Figure imgf000085_0003
3,5-dichloro-lH-indole-4-sulfonic acid
443 [3-(2-cyano-pyrrol- 1 -yl)- 1 -(4-methyl- piperidine- 1 -carbonyl)-propyl] -amide
Figure imgf000085_0004
(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH- indol-4- ylsulf onyl) amino] butanoyl } piperidin- 3 - yl) acetic acid
(2E)-3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-
2-[(lH-indol-4- ylsulf onyl) amino] butanoyl } piperidin-3 - yl)prop-2-enoic acid
Figure imgf000085_0005
Example Structure Name
3 -( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-3- yl)propanoic acid
Figure imgf000086_0001
3 -( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-4- yl)propanoic acid
4-( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-4- yl)butanoic acid
Figure imgf000086_0002
4-( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-3- yl)butanoic acid
3-{4-[({3-(2-cyano-lH-pyrrol-l-yl)-l-
[(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino)sulfonyl] - lH-indol-3-yl} propanoic acid
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } - l,2,3,4-tetrahydroisoquinoline-6- carboxylic acid
Figure imgf000086_0003
Example Structure Name
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H- indol-4-ylsulfonyl)amino]butanoyl } - l,2,3,4-tetrahydroisoquinoline-7- carboxylic acid
3-[(cis)-l-{4-(2-cyano-lH-pyrrol-l-yl)-
2-[(lH-indol-4- ylsulfonyl)amino]butanoyl } -A-
Figure imgf000087_0001
methylpiperidin-3-yl]propanoic acid
454
Figure imgf000087_0002
2- [(2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-
[(lH-indol-4-
455 ylsulfonyl)amino]butanoyl}-l,2,3,4- tetrahydroisoquinolin-7-yl)oxy]-2-
Figure imgf000087_0003
methylpropanoic acid
In still another embodiment of the invention, there are provided compounds of the formula (I) selected from the group below or a tautomer thereof or a salt thereof:
N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-methylpiperidin- 1 -yl)carbonyl]propyl } thiophene-3- sulfonamide N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl}-2- methylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl}-3- methylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl} -4- methylbenzenesulfonamide
N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3-( 1 H-pyrazol- 1 -yl)propyl } - 1 H-indole-4- sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl} -2,4- dimethylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl} -2,5- dimethylbenzenesulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl}-3, 5- dimethylbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2- methoxybenzenesulfonamide
N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -3- methoxybenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -A- methoxybenzenesulfonamide
N- [ 1 - { [4-(hydroxymethyl)piperidin- 1 -yl]carbonyl } -3-(l H-pyrazol- 1 -yl)propyl] - 1 H-indole-4- sulfonamide
N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 ,3,5-trimethyl-
1 H-pyrazole-4-sulfonamide N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-4-fluoro-2- methylbenzenesulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
4-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2, 5- dimethylthiophene- 3 - sulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}pyridine-3-sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-3 - sulfonamide
2-cyano-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -5 - methylbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-6- sulfonamide
N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 -benzofuran-7- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indazole-4- sulfonamide N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indazole-6- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-5 - sulfonamide
N- { 3 -(3-cyano- 1 H-pyrazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- { 3 -(5-cyano- 1 H-pyrazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2,4,6- trimethylbenzenesulfonamide
3-amino-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2,4- dimethylbenzenesulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 -yl] carbonyl } propyl] -2,5- dimethylbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2-methoxy-4- methylbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2-methoxy-5- methylbenzenesulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -6- methylbenzenesulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2- methylbenzenesulfonamide
N- { 3 -(5-chloro- 1 H-pyrazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
; of 267 N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-methylpiperidin- 1 -yl)carbonyl]propyl Jnaphthalene- 1 - sulfonamide
N-benzyl-4-(2-cyano-l H-pyrrol- l-yl)-2-{ [(2, 5-dimethylphenyl)sulfonyl] amino} -N- methylbutanamide
N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl }isoquinoline-5- sulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -A- fluorobenzenesulfonamide
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 ,3- dimethyl- 1 H-pyrazole-4-sulfonamide
N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 -methyl- 1 H- indole-4-sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 - benzothiophene- 3 - sulfonamide
N- [3-(5-cyano- lH-pyrazol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 -yl]carbonyl } propyl] - 1 H- indole-4-sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 -yl] carbonyl } propyl] - 1 H- indazole-4-sulfonamide methyl 2- [( { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl]benzoate
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -5-ethyl-2- methoxybenzenesulfonamide
N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 -yl)propyl } - 1 H-indole-4- sulfonamide N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3-(2-nitro- 1 H-imidazol- 1 -yl)propyl } - lH-indole-6- sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl} -2,5- dimethoxybenzenesulfonamide
N-benzyl-4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino] -N- methylbutanamide
2-chloro-N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]-6-methylbenzenesulfonamide
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2- methoxybenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -A- methylnaphthalene- 1 -sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 - yl]carbonyl}propyl]naphthalene-l -sulfonamide
2,3-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide
2,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide
3,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2-
(trifluoromethyl)benzenesulfonamide N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(trans)-octahydroisoquinolin-2(lH)-ylcarbonyl]propyl}-
2 , 5 -dimethylbenzenesulfonamide
2-chloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-4,5- difluorobenzenesulfonamide
N-benzyl-2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -3 - methyl- 1 -benzothiophene-2-sulfonamide
N- { 4- [( { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl] -3-methylphenyl } acetamide methyl 1 - { 3- [(I H-indol-4-ylsulfonyl)amino] -4-(4-methylpiperidin- 1 -yl)-4-oxobutyl } - IH- pyrrole-2-carboxylate
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 -methyl-3 -
(trifluoromethyl)- 1 H-pyrazole-4-sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -4-methoxy-
2 , 3 , 6-trimethylbenzenesulf onamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-5-methyl-2,l,3- benzothiadiazole-4-sulfonamide
2,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}thiophene-3-sulfonamide
2-bromo-N-[3-(2-cyano-l H-pyrrol- l-yl)-l -(piperidin-l-ylcarbonyl)propyl] -6- methylbenzenesulfonamide
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(trans)-octahydroisoquinolin-2(lH)-ylcarbonyl]propyl}-
1 H-indole-4-sulfonamide
6-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } imidazo[2, 1 -b] [ 1 ,3] thiazole-5 -sulfonamide
2,4-dichloro-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-methylpiperidin- 1 -yl)carbonyl]propyl } -5- methylbenzenesulfonamide
2,4-dichloro-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-methylpiperidin- 1 -yl)carbonyl]propyl } -6- methylbenzenesulfonamide
2-amino-4,6-dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -[(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
4-amino-2,5 -dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
4-chloro-2,5-dimethyl-N-{ 1 -[(4-methylpiperidin- l-yl)carbonyl]-3-(2-nitro-lH-imidazol-l- yl)propyl Jbenzenesulfonamide
4-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}thiophene-3-sulfonamide
2,6-dichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{ [4-(hydroxymethyl)piperidin-l- yl] c arbonyl } propyl] benzenesulf onamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-cyano- 1 H-imidazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
4-amino-3,5-dichloro-N- { 3-(5-cyano- lH-pyrazol- 1 -yl)- 1- [(4-methylpiperidin- 1- yl)carbonyl]propyl}benzenesulfonamide 4-chloro-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-methylpiperidin- 1 - yl)carbonyl]propyl } naphthalene- 1 -sulfonamide
N-(4-chlorobenzyl)-4-(2-cyano-lH-pyrrol-l-yl)-2-{ [(2,5-dimethylphenyl)sulfonyl]amino}-N- methylbutanamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2-
(trifluoromethoxy)benzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -4-fluoro-2-
(trifluoromethyl)benzenesulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-2( 1 H)- ylcarbonyl] propyl } -6-methylbenzenesulfonamide methyl 3 - [( { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl] -4-methoxybenzoate
N-benzyl-4-(2-cyano-l H-pyrrol- l-yl)-2-{ [(2, 6-dichlorophenyl)sulfonyl] amino} -N- methylbutanamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-2( 1 H)- ylcarbonyl] propyl } naphthalene- 1 -sulfonamide
2-bromo-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -6- methylbenzenesulfonamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
N- { 3 -(5-bromo- 1 H-pyrazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -A- fluorobenzenesulfonamide 2-acetyl-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-methylpiperidin- 1 -yl)carbonyl]propyl } - l,2,3,4-tetrahydroisoquinoline-7-sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl}-4-(2-methyl- l,3-thiazol-4-yl)benzenesulfonamide
2,4,6-trichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)c arbonyl] propyl } benzenesulf onamide
2,4-dichloro-6-methyl-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3-(2-nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulf onamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(2-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
4-amino-3 ,5 -dichloro-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulf onamide
N-(4-chlorobenzyl)-2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 - yl)-N-methylbutanamide
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(trans)-octahydroisoquinolin-2(lH)- ylc arbonyl] propyl } benzenesulf onamide
5 -bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2- methoxybenzenesulfonamide
N- [3-(5-bromo- 1 H-pyrazol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 -yl]carbonyl } propyl] - 1 H- indole-4-sulfonamide
2-bromo-6-methyl-N-{ l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-lH-imidazol-l- yl)propyl } benzenesulf onamide
2-bromo-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -4,6- difluorobenzenesulfonamide 2,4,6-trichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{ [4-(hydroxymethyl)piperidin-l- yl]carbonyl}propyl]benzenesulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 -yl] carbonyl } propyl] - 1 H- indole-6-sulfonamide
N- [ 1 -(3 ,4-dihydroisoquinolin-2( 1 H)-ylcarbonyl)-3 -(2-nitro- 1 H-imidazol- 1 -yl)propyl] -A- methylnaphthalene- 1 -sulfonamide
5-bromo-N- { 3 -(2-cy ano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2,3 - dihydro- 1 -benzofuran-7-sulfonamide
N-benzyl-4-(2-cyano-lH-pyrrol-l-yl)-N-methyl-2-{ [(2,4,6- trichlorophenyl)sulfonyl] amino Jbutanamide
4-methyl-N- { 3-(2-nitro- 1 H-imidazol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-2( 1 H)- ylcarbonyl] propyl } naphthalene- 1 - sulfonamide
2,6-dichloro-N- { 3 -(2-nitro- 1 H-imidazol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-2( 1 H)- ylcarbonyl]propyl}benzenesulfonamide
2-bromo-N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1- { [4-(hydroxymethyl)piperidin- 1 - yl] c arbonyl } propyl] -4 , 6-difluorobenzenesulf onamide
2-amino-4,6-dichloro-N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-
2(1 H)-ylcarbonyl]propyl } benzenesulfonamide
2-amino-4,6-dichloro-N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-
2(1 H)-ylcarbonyl]propyl } benzenesulfonamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-
2(1 H)-ylcarbonyl]propyl } benzenesulfonamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-
2(1 H)-ylcarbonyl]propyl } benzenesulfonamide N-benzyl-2- { [(2-bromo-4, 6-difluorophenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2, 5- bis(trifluoromethyl)benzenesulfonamide
4-amino-N- { 3-(2-bromo- 1 H-imidazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -
3 ,5-dichlorobenzenesulfonamide
2-amino-4,6-dichloro-N-[l-(3,4-dihydroisoquinolin-2(lH)-ylcarbonyl)-3-(2-nitro-lH- imidazol- 1 -yl)propyl]benzenesulfonamide
2-{ [(4-amino-3,5-dichlorophenyl)sulfonyl]amino}-N-(4-chlorobenzyl)-4-(2-cyano-lH- pyrrol- 1 -yl)-N-methylbutanamide
2,4,6-trichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(trans)-octahydroisoquinolin-2(lH)- ylc arbonyl] propyl } benzenesulf onamide
2-amino-4,6-dichloro-N- { 3 -(2-nitro- 1 H-imidazol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-2( 1 H)- ylc arbonyl] propyl } benzenesulf onamide
2-amino-4,6-dichloro-N- { 3 -(2-nitro- 1 H-imidazol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-
2(1 H)-ylcarbonyl]propyl } benzenesulfonamide
2-bromo-N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -5-
(trifluoromethyl)benzenesulfonamide
4-bromo-2,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}thiophene-3-sulfonamide tert-butyl 3 - [( { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl] -2-methyl- lH-indole- 1 -carboxylate
2-bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-2( 1 H)- ylc arbonyl] propyl } -4, 6-difluorobenzenesulf onamide 5-chloro-4- [3-(2-cyano-pyrrol- 1 -yl)- 1 -(4-methyl-piperidine- 1 -carbonyl)-propylsulfamoyl] - indole- 1-carboxy lie acid tert-butyl ester
4-amino-3 ,5-dibromo-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulf onamide
3-chloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-lH- indazole-5 -sulfonamide
4-amino-3,5-dichloro-N- { 3-(5-chloro- lH-pyrazol- l-yl)-l - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
2-amino-4,6-dichloro-N- { 3 -(2-chloro- 1 H-imidazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
2-amino-4,6-dichloro-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulf onamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-pyrrolo [2,3- b]pyridine-4-sulfonamide
3 -bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- pyrrolo [2 , 3 -b] pyridine-4-sulf onamide
2,6-dichloro-N-{3-(2-chloro-lH-imidazol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide
2,6-dichloro-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl } benzenesulf onamide
N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 -yl)propyl } naphthalene- 1 - sulfonamide
2,4,6-trimethyl-N-{ l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-lH-imidazol-l- yl)propyl } benzenesulf onamide 2-chloro-6-methyl-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -(2-nitro- 1 H-imidazol- 1 - yl)propyl Jbenzenesulfonamide
4-bromo-2,5-dichloro-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3-(2-nitro- 1 H-imidazol- 1 - yl)propyl } thiophene- 3 - sulfonamide
4-amino-3 ,5 -dichloro-N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3 -( 1 H-pyrrol- 1 - yl)propyl Jbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methyl-3 ,6-dihydropyridin- 1 (2H)-yl)carbonyl]propyl } - 1 H-indole-4-sulfonamide
N- [ 1 -(azepan- 1 -ylcarbonyl)-3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl] - 1 H-indole-4-sulfonamide N- [ 1 -(azepan- 1 -ylcarbonyl)-3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl] - 1 H-indole-6-sulfonamide N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(2-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-6- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(3 -methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(3 -methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-6- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-oxopiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperazin- 1 -yl)carbonyl]propyl } - 1 H- indoles- sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -( 1 ,4-oxazepan-4-ylcarbonyl)propyl] - 1 H-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(3 -hydroxypiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-hydroxypiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- { 3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -[(4-fluoropiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- [ 1 -(azepan- 1 -ylcarbonyl)-3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl] -2-chloro-6- methylbenzenesulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(2-methylpiperidin- 1 -yl)carbonyl]propyl } -6- methylbenzenesulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(3 -methylpiperidin- 1 -yl)carbonyl]propyl } -6- methylbenzenesulfonamide
N- [ 1 -(6-azaspiro[2.5 ] oct-6-ylcarbonyl)-3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl] - 1 H-indole-4- sulfonamide
N-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-lH-indole-6- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(5 -oxo- 1 ,4-diazepan- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [2-(hydroxymethyl)piperidin- 1 -yl] carbonyl } propyl] - 1 H- indole-4-sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [3 -(hydroxymethyl)piperidin- 1 -yl] carbonyl } propyl] - 1 H- indole-4-sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 -yl] carbonyl } propyl] - 1 H- indole-4-sulfonamide
N- [ 1 -(6-azaspiro[2.5 ] oct-6-ylcarbonyl)-3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl] -2-chloro-6- methylbenzenesulfonamide N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-propylpiperidin- 1 -yl)carbonyl]propyl } - lH-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-propylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-6- sulfonamide
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide
N-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-2,6- dichlorobenzenesulfonamide
N- { 1 -[(4-acetylpiperazin- l-yl)carbonyl] -3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl }- lH-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4,4-difluoropiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(2-hydroxyethyl)piperidin- 1 -yl]carbonyl Jpropyl] - 1 H- indole-4-sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(methoxymethyl)piperidin- 1 -yl] carbonyl Jpropyl] - 1 H- indole-4-sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -(3 ,4-dihydroisoquinolin-2( 1 H)-ylcarbonyl)propyl] - 1 H- indole-4-sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -(3 ,4-dihydroisoquinolin-2( 1 H)-ylcarbonyl)propyl] - 1 H- indole- 6- sulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-propylpiperidin- 1 -yl)carbonyl]propyl } -6- methylbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-2( 1 H)-ylcarbonyl]propyl } - 1 H- indole-4-sulfonamide N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)-octahydroisoquinolin-2(lH)-ylcarbonyl]propyl}-lH- indole-6-sulfonamide
N-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-2,6- dichlorobenzenesulfonamide
2-chloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydroisoquinolin-2(lH)- ylcarbonyl)propyl]-6-methylbenzenesulfonamide
N- { 1 - [(4-acetyl- 1 ,4-diazepan- 1 -yl)carbonyl] -3 -(2-cyano- 1 H-pyrrol- 1 -yl)propyl } - 1 H-indole-
4-sulfonamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(2-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
4-amino-3,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide
4-amino-N-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-3,5- dichlorobenzenesulfonamide methyl 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-[( lH-indol-4-ylsulfonyl)amino]butanoyl Jpiperidine-
4-carboxylate methyl 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-[( lH-indol-6-ylsulfonyl)amino]butanoyl Jpiperidine-
4-carboxylate
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(l,4-dioxa-8-azaspiro[4.5]dec-8-ylcarbonyl)propyl]-lH- indole-4-sulfonamide
2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-(3 - fluorobenzyl)-N-methylbutanamide
2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-(4- fluorobenzyl)-N-methylbutanamide 2-chloro-N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-2( 1 H)- ylcarbonyl] propyl } -6-methylbenzenesulfonamide methyl 1 - [2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 - yl)butanoyl]piperidine-4-carboxylate
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(trifluoromethyl)piperidin- 1 -yl] carbonyl } propyl] - 1 H- indole-4-sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(trifluoromethyl)piperidin- 1 -yl] carbonyl } propyl] - 1 H- indole- 6- sulfonamide
4-amino-N-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-3,5- dichlorobenzenesulfonamide methyl ( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } piperidin-
4-ylidene)acetate
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-propylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide methyl ( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } piperidin-
2-yl)acetate methyl ( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } piperidin-
3 -yl) acetate methyl ( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } piperidin-
4-yl)acetate
3-chloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6-dihydro[l,2,4]triazolo[4,3-a]pyrazin-7(8H)- ylcarbonyl)propyl]-lH-indole-4-sulfonamide
4-amino-3,5-dichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{ [4-(hydroxymethyl)piperidin-l- yl] c arbonyl } propyl] benzenesulf onamide 2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-(2- methoxybenzyl)-N-methylbutanamide
2,6-dichloro-N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)-l -(3 ,4-dihydroisoquinolin-2( 1 H)- ylc arbonyl)propyl] benzenesulf onamide
2-chloro-N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]-6-methylbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-phenylpiperazin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-pyrimidin-2-ylpiperazin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
2,6-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)-octahydroisoquinolin-2(lH)- ylc arbonyl] propyl } benzenesulf onamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -{ [4-( 1 ,3 -thiazol-2-yl)piperazin- 1 -yl] carbonyl } propyl] - 1 H- indole-4-sulfonamide methyl (2E)-3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-3-yl)prop-2-enoate
N-[2-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}piperidin-4- yl)ethyl] acetamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-propylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide methyl 3 -( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4- ylsulf onyl)amino] butanoyl } piperidin- 3 -yl)propanoate methyl 3 -( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4- ylsulfonyl)amino]butanoyl}piperidin-4-yl)propanoate N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6-dihydro[l,2,4]triazolo[4,3-a]pyrazin-7(8H)- ylcarbonyl)propyl]-lH-indole-4-sulfonamide methyl 1 -[4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- { [(2,6- dichlorophenyl)sulfonyl]amino}butanoyl]piperidine-4-carboxylate
2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-(2-methoxy-5 - methylbenzyl)-N-methylbutanamide
2,6-dichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{ [4-(trifluoromethyl)piperidin-l- yl] c arbonyl } propyl] benzenesulf onamide methyl 4-( 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4- ylsulfonyl)amino]butanoyl}piperidin-4-yl)butanoate methyl 1 - [2- { [(4-amino-3 ,5 -dichlorophenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 - yl)butanoyl]piperidine-4-carboxylate methyl 2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2-[( lH-indol-4-ylsulfonyl)amino]butanoyl } - 1 ,2,3,4- tetrahydroisoquinoline-6-carboxylate
2- { 4-(2-cyano- lH-pyrrol- 1 -yl)-2- [(I H-indol-4-ylsulfonyl)amino]butanoyl } - 1 ,2,3,4- tetrahydroisoquinoline-7-carboxylic acid methyl ester
2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N- [4-( 1 H- imidazol- 1 -yl)benzyl] -N-methylbutanamide
3 - [(cis)- 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } -A- methylpiperidin-3-yl]propanoic acid
2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(3- pyridin-3 -ylbenzyl)butanamide
2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(4- pyrimidin- 5 -ylbenzyl)butanamide 2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-(3- pyrimidin-5 -ylbenzyl)butanamide
2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 -yl)-N-methyl-N-[3- (5-methyl- 1 ,2,4-oxadiazol-3-yl)benzyl]butanamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-nitro- 1 H-imidazol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin- 2(1 H)-ylcarbonyl]propyl } benzenesulfonamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,6-dihydropyridin-l(2H)-ylcarbonyl)propyl]-lH-indole- 4-sulfonamide
N- [3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -(piperidin- 1 -ylcarbonyl)propyl] - 1 H-indole-4-sulfonamide N- [3-(2-cyano- lH-pyrrol- 1 -yl)- 1 -(piperidin- 1 -ylcarbonyl)propyl] - 1 H-indole-6-sulfonamide 2-chloro-N-[3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 -(piperidin- 1 -ylcarbonyl)propyl] -6- methylbenzenesulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-oxoazepan- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [(trans)-3 -hydroxy-4-methylpiperidin- 1 - yl] c arbonyl } propyl] - 1 H-indole-4- sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(3 ,4-dimethylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole- 4-sulfonamide
N-benzyl-4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-6-ylsulfonyl)amino] -N- methylbutanamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6-dihydro-imidazo[4,3-a]pyrazin-7(8H)- ylcarbonyl)propyl]-lH-indole-4-sulfonamide
4-amino-3,5-dichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(piperidin-l- ylc arbonyl)propyl] benzenesulfonamide N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-ylcarbonyl)propyl]- lH-indole-4-sulfonamide
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(trans)-octahydroisoquinolin-2(lH)-ylcarbonyl]propyl}-
1 H-indole- 6- sulfonamide
4-amino-3,5-dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)-l -[(4-methylenepiperidin- 1- yl)carbonyl]propyl}benzenesulfonamide lH-indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(7-cyano-3,4-dihydro-lH-isoquinoline-
2-carbonyl)-propyl] -amide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-phenylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide
2- { [(4-amino-3,5-dichlorophenyl)sulfonyl] amino } -N-benzyl-4-(2-cyano- 1 H-pyrrol- 1 -yl)-N- methylbutanamide ethyl 1 -[2- { [(2-chloro-6-methylphenyl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 - yl)butanoyl]piperidine-3-carboxylate
N- [3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(3 -methyl- 1 ,2,4-oxadiazol-5 -yl)piperidin- 1 - yl] c arbonyl } propyl] - 1 H-indole-4- sulfonamide
4-amino-3,5-dichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydroisoquinolin-2(lH)- ylc arbonyl)propyl] benzenesulf onamide lH-indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(7-nitro-3,4-dihydro-lH-isoquinoline-
2-carbonyl)-propyl] -amide
4-amino-3 ,5 -dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(cis)-octahydroisoquinolin-2( 1 H)- ylc arbonyl] propyl } benzenesulf onamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(trans)-octahydroisoquinolin-2( 1 H)- ylc arbonyl] propyl } benzenesulf onamide lH-indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(8-nitro-l,3,4,5-tetrahydro-2- benzazepine-2-carbonyl)-propyl]-amide
4-amino-3 ,5-dichloro-N-[3-(2-cyano- lH-pyrrol- 1 -yl)- 1 - { [4-(trifluoromethyl)piperidin- 1 - yl]carbonyl}propyl]benzenesulfonamide
2- { 4-(2-cyano- lH-pyrrol- 1 -yl)-2- [(I H-indol-4-ylsulfonyl)amino]butanoyl } - 1 ,2,3,4- tetrahydroisoquinoline-7-sulfonamide
2- { 4-(2-cyano- lH-pyrrol- 1 -yl)-2- [(I H-indol-4-ylsulfonyl)amino]butanoyl } - 1 ,2,3,4- tetrahydroisoquinoline-7-sulfonic acid
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } -N-methyl- l,2,3,4-tetrahydroisoquinoline-7-sulfonamide
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } -N,N-dimethyl- l,2,3,4-tetrahydroisoquinoline-7-sulfonamide
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } -N-methyl- l,2,3,4-tetrahydroisoquinoline-7-carboxamide
2- { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [( 1 H-indol-4-ylsulfonyl)amino]butanoyl } -N,N-dimethyl- l,2,3,4-tetrahydroisoquinoline-7-carboxamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{ [7-(morpholin-4-ylcarbonyl)-3,4-dihydroisoquinolin-
2(1 H)-yl] carbonyl Jpropyl] - 1 H-indole-4-sulfonamide
4-amino-3,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4- methylcyclohexy^carbonyljpropyljbenzenesulfonamide
N-[3-(2-cyano-lH-pyrrol-l-yl)-l-({4-[(E/Z)-(methoxyimino)methyl]piperidin-l- yl } carbonyl)propyl] - 1 H-indole-4-sulfonamide
1 -acetyl-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide tert-butyl 4- [( { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl } amino) sulfonyl] - 1 H-indole- 1 -carboxylate
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -N-methyl- 1 H- indole-4-sulfonamide
4- { 4-(2-cyano- lH-pyrrol- 1 -yl)-2- [(I H-indol-4-ylsulfonyl)amino]butanoyl } - 1 ,4-diazepane- 1 - carboxamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-glycoloyl- 1 ,4-diazepan- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -4-( 1 H- tetrazol-5-yl)benzenesulfonamide
4-amino-3 ,5 -dichloro-N- { 3 -(2-chloro- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide
3 -bromo-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
3 -cyano-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2-oxoindoline-
4-sulfonamide
N- { 3 -(3-bromo-2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2- oxoindoline-4-sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -3-formyl- 1 H- indole-4-sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-7- sulfonamide N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2-methyl- 1 H- indole- 3 - sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -5-fluoro- 1 H- indole-4-sulfonamide
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -5-fluoro- 1 H- indole- 6- sulfonamide
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
5 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole- 6- sulfonamide
S-chloro-lH-indole-ό-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(5,6-dihydro-8H-
[l,2,4]triazolo[4,3-a]pyrazine-7-carbonyl)-propyl]-amide ethyl 3- {4-[({ 3 -(2-cyano- 1 H-pyrrol- l-yl)-l -[(4-methylpiperidin- 1- yl)carbonyl]propyl } amino) sulfonyl] - 1 H-indol-3-yl Jpropanoate
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-5-methyl-2,3- dihydro- 1 -benzofuran-7-sulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole- 6- sulfonamide
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide
3 -chloro-N- { 3 -(5 -cyano- 1 H-pyrazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H- indole-4-sulfonamide methyl 1 - [2- { [(3-chloro- 1 H-indol-4-yl)sulfonyl] amino } -4-(2-cyano- 1 H-pyrrol- 1 - yl)butanoyl]piperidine-4-carboxylate 3-chloro-N- [3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - { [4-(hydroxymethyl)piperidin- 1 - yl]carbonyl} propyl] -lH-indole-4-sulfonamide
(2E)-3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}piperidin-
3-yl)prop-2-enoic acid
3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}piperidin-3- yl)propanoic acid
4-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}piperidin-4- yl)butanoic acid
4-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}piperidin-3- yl)butanoic acid
2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}-l,2,3,4- tetrahydroisoquinoline-6-carboxylic acid
2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}-l,2,3,4- tetrahydroisoquinoline-7-carboxylic acid
3- [(cis)- 1 - { 4-(2-cyano- 1 H-pyrrol- 1 -yl)-2- [(I H-indol-4-ylsulfonyl)amino]butanoyl } -A- methylpiperidin-3-yl]propanoic acid
2-[(2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino]butanoyl}-l,2,3,4- tetrahydroisoquinolin-7-yl)oxy] -2-methylpropanoic acid
In all the compounds disclosed in this application, in the event the nomenclature is in conflict with the structure, it shall be understood that the compound is defined by the structure.
Some of the compounds of formula (I) can exist in more than one tautomeric form. The invention includes methods using all such tautomers. All terms as used herein in this specification, unless otherwise stated, shall be understood in their ordinary meaning as known in the art. For example, "Ci_6 alkoxy" is a Ci_4alkyl that contain an oxygen atom, such as methoxy, ethoxy, propoxy, or butoxy.
The term "Ci_io-alkyl" (including those which are part of other groups) refers to branched and unbranched alkyl groups with 1 to 10 carbon atoms, by the term "Ci_6-alkyl" accordingly means branched and unbranched alkyl groups with 1 to 6 carbon atoms. "Ci_4-alkyl" accordingly denotes branched and unbranched alkyl groups with 1 to 4 carbon atoms. Alkyl groups with 1 to 4 carbon atoms are preferred. Examples include: methyl, ethyl, «-propyl, ώo-propyl, «-butyl, ώo-butyl, sec-butyl, tert-buty\, «-pentyl, ώo-pentyl, «eo-pentyl or hexyl. Optionally the abbreviations Me, Et, «-Pr, /-Pr, «-Bu, /-Bu, f-Bu, etc. may also be used for the above-mentioned groups. Unless stated otherwise, the definitions propyl, butyl, pentyl and hexyl include all the possible isomeric forms of the groups in question. Thus, for example, propyl includes «-propyl and ώø-propyl, butyl includes ώo-butyl, sec-butyl and tert-butyl etc.
By the term "C2-6-alkenyl" (including those which are part of other groups) refers to branched and unbranched alkenyl groups with 2 to 6 carbon atoms and by the term "C2-4-alkenyl" refers to branched and unbranched alkenyl groups with 2 to 4 carbon atoms, provided that they have at least one double bond. Alkenyl groups with 2 to 4 carbon atoms are preferred. Examples include: ethenyl or vinyl, propenyl, butenyl, pentenyl, or hexenyl. Unless stated otherwise, the definitions propenyl, butenyl, pentenyl and hexenyl include all the possible isomeric forms of the groups in question. Thus, for example, propenyl includes 1 -propenyl and 2- propenyl, butenyl includes 1-, 2- and 3-butenyl, 1 -methyl- 1 -propenyl, 1 -methyl-2-propenyl etc.
I l l of 267 By the term "C2-6-alkynyl" (including those which are part of other groups) refers to branched and unbranched alkynyl groups with 2 to 6 carbon atoms and by the term "C2-4-alkynyl" refers to branched and unbranched alkynyl groups with 2 to 4 carbon atoms, provided that they have at least one triple bond. Alkynyl groups with 2 to 4 carbon atoms are preferred. Examples include: ethynyl, propynyl, butynyl, pentynyl or hexynyl. Unless stated otherwise, the definitions propynyl, butynyl, pentynyl and hexynyl include all the possible isomeric forms of the groups in question. Thus for example propynyl includes 1 -propynyl and 2- propynyl, butynyl includes 1, 2- and 3 -butynyl, 1 -methyl- 1 -propynyl, 1 -methyl-2-propynyl etc.
The term "cycloalkyl" shall be understood to mean an aliphatic hydrocarbon radical containing from three to twelve carbon atoms. Cycloalkyls include hydrocarbon rings containing from three to ten carbon atoms. These cycloalkyls may be either aromatic or non- aromatic ring systems. The non-aromatic ring systems may be mono- or polyunsaturated. Preferred cycloalkyls include, but are not limited, to cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptanyl, cycloheptenyl, phenyl, indanyl, indenyl, benzocyclobutanyl, dihydronaphthyl, tetrahydronaphthyl, naphthyl, decahydronaphthyl, benzocycloheptanyl, and benzocycloheptenyl. Certain terms for cycloalkyl, such as cyclobutanyl and cyclobutyl, shall be used inerchangeably.
The term "heterocycle" refers to a stable, nonaromatic, 4-8 membered (but preferably 5 or 6 membered) monocyclic or nonaromatic, 8-11 membered, bicyclic heterocycle radical that may be either saturated or unsaturated. Each heterocycle consists of carbon atoms and at least one, i.e., 1-4, heteroatoms chosen from, e.g., nitrogen, oxygen, or sulfur. The heterocycle may be attached by any atom of the cycle that results in the creation of a stable structure. Unless otherwise stated, heterocycles include, but are not limited to, for example, aziridinyl, azetidinyl, pyrrolidinyl, pyrrolinyl, morpholinyl, thiomorpholinyl, thiomorpholinyl sulfoxide, thiomorpholinyl sulfone, dioxalanyl, piperidinyl, piperazinyl, tetrahydrofuranyl, 1 -oxo-lambda-4-thiomorpholinyl, 13-oxa- 11 -aza-tricyclo[7.3.1.0- 2,7]trideca-2,4,6-triene, tetrahydropyranyl, 2-oxo-2H-pyranyl, tetrahydrofuranyl, 1,3- dioxolanone, 1,3-dioxanone, 1,4-dioxanyl, 8-oxa-3-aza-bicyclo[3.2.1]octanyl, 2-oxa-5-aza- bicyclo[2.2. l]heptanyl, 2-thia-5-aza-bicyclo[2.2. l]heptanyl, piperidinonyl, tetrahydropyrimidonyl, pentamethylene sulfide, pentamethylene sulfoxide, pentamethylene sulfone, tetramethylene sulfide, tetramethylene sulfoxide, and tetramethylene sulfone.
The term "heteroaryl" shall be understood to mean an aromatic 5-8 membered monocyclic or 8-11 membered bicyclic ring containing 1-4 heteroatoms, such as N, O, and S. Unless otherwise stated, such heteroaryls include thienyl, furanyl, isoxazolyl, oxazolyl, thiazolyl, thiadiazolyl, tetrazolyl, pyrazolyl, pyrrolyl, imidazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl, pyranyl, quinoxalinyl, indolyl, benzimidazolyl, benzoxazolyl, benzothiazolyl, benzothienyl, quinolinyl, quinazolinyl, naphthyridinyl, indazolyl, triazolyl, pyrazolo[3,4- b]pyrimidinyl, purinyl, pyrrolo[2,3-b]pyridinyl, pyrazolo[3,4-b]pyridinyl, tubercidinyl, oxazo[4,5-£]pyridinyl, and imidazo[4,5-£]pyridinyl.
In all alkyl groups or carbon chains, one or more carbon atoms can be optionally replaced by heteroatoms, such as O, S, or N. It shall be understood that, if N is not substituted, then it is NH. It shall also be understood that heteroatoms may replace either terminal carbon atoms or internal carbon atoms within a branched or unbranched carbon chain. Such groups can be substituted as herein above described by groups, such as oxo, to result in definitions, such as, but not limited to, alkoxycarbonyl, acyl, amido, and thioxo. The term "aryl" shall be understood to mean aromatic cycloalkyl or heteroaryl as defined herein. Each aryl unless otherwise specified includes it's partially or fully hydrogenated derivative. For example, quinolinyl may include decahydroquinolinyl and tetrahydroquinolinyl, and naphthyl may include its hydrogenated derivatives, such as tetrahydranaphthyl. Other partially or fully hydrogenated derivatives of the aryl compounds described herein will be apparent to one of ordinary skill in the art.
Terms that are analogs of the above cyclic moieties, such as aryloxy or heteroaryl amine, shall be understood to mean an aryl, heteroaryl, and/or heterocycle as defined above attached to its respective group.
As used herein, "nitrogen" and "sulfur" include any oxidized form of nitrogen and sulfur and the quaternized form of any basic nitrogen. For example, for an -S-Ci-6 alkyl radical, unless otherwise specified, this shall be understood to include -S(O)-Ci_6 alkyl and -S(O)2-Ci-6 alkyl.
The term "halogen" as used herein shall be understood to mean bromine, chlorine, fluorine or iodine. The definitions "partially or fully halogenated" and "substituted by one or more halogen atoms" include, for example, mono-, di-, or tri-halo derivatives on one or more carbon atoms. For alkyl, non-limiting examples would be -CH2CHF2, -CF3, etc.
The term "ureido" means the general formula of either C(0)NRxRy or NHC(O)R*.
The term "carbamoyl" means the general formula C(0)NRxRy or NHC(O)RX. The compounds of the invention are only those which are contemplated to be chemically stable as will be appreciated by those skilled in the art. For example, a compound that would have a dangling valency or carbanion is not a compound contemplated by the present invention.
The invention includes pharmaceutically acceptable derivatives of compounds of formula (I). A "pharmaceutically acceptable derivative" refers to any pharmaceutically acceptable salt or ester, or any other compound that, upon administration to a patient, is capable of providing (directly or indirectly) a compound useful for the invention, or a pharmacologically active metabolite, or pharmacologically active residue thereof. A pharmacologically active metabolite shall be understood to mean any compound of the invention capable of being metabolized enzymatically or chemically. This includes, for example, hydroxylated or oxidized derivative compounds of the formula (I).
Pharmaceutically acceptable salts include those derived from pharmaceutically acceptable inorganic and organic acids and bases. Examples of suitable acids include hydrochloric, hydrobromic, sulfuric, nitric, perchloric, fumaric, maleic, phosphoric, glycolic, lactic, salicylic, succinic, toluene -p-sulfuric, tartaric, acetic, citric, methanesulfonic, formic, benzoic, malonic, naphthalene-2-sulfuric, and benzenesulfonic acids. Other acids, such as oxalic acid, while not themselves pharmaceutically acceptable per se, may be employed in the preparation of salts useful as intermediates in obtaining the compounds and their pharmaceutically acceptable acid addition salts. Salts derived from appropriate bases include alkali metal (e.g., sodium), alkaline earth metal (e.g., magnesium), ammonium, and N-(Cl- C4 alkyl)4+ salts. In addition, within the scope of the invention is use of prodrugs of compounds of the formula (I). Prodrugs include those compounds that, upon simple chemical transformation, are modified to produce compounds of the invention. Simple chemical transformations include hydrolysis, oxidation, and reduction. Specifically, when a prodrug is administered to a patient, the prodrug may be transformed into a compound disclosed hereinabove, thereby imparting the desired pharmacological effect.
General Synthetic Methods
The invention additionally provides for methods for making the compounds of the formula (I). The compounds of the invention may be prepared by the general methods and examples presented below, and methods known to those of ordinary skill in the art. Optimum reaction conditions and reaction times may vary depending on the particular reactants used. Unless otherwise specified, solvents, temperatures, pressures, and other reaction conditions may be readily selected by one of ordinary skill in the art. Specific procedures are provided in the Synthetic Examples section. Reaction progress may be monitored by conventional methods such as thin layer chromatography (TLC) or mass spectrometry (MS). Intermediates and products may be purified by methods known in the art, including column chromatography, HPLC, or recrystallization.
Compounds of formula (I) having R3 = -NR5R6 may be prepared as illustrated in Scheme 1. Aminobutyrolactone II is treated with HBr in HOAc to provide the HBr salt of the bromo amino acid III. Esterification, for example by treatment with MeOH and acetyl chloride, thionyl chloride or HCl gas, followed by protection of the amine with a suitable protecting group such as the Boc group shown provides the protected amino ester IV. Treatment with the salt of a desired heterocycle in a suitable solvent such as DMF provides V. Removal of the amine protecting group, for example by treatment with HCl or TFA for the Boc- protecting group, provides amino ester VI. Treatment with a sulfonyl chloride bearing the desired R1 in the presence of a suitable base such as triethylamine or 1-methylmorpholine provides sulfonamide VII. Hydrolysis of the ester, for example with aqueous base, followed by treatment of the resulting acid with a suitable coupling agent such as a dialkylcarbodimide with HOBt, or HATU with a suitable base such as /-Pr2NEt and the desired amine HNR5R6 provides the desired compound of formula (I) (R3 = -NR R ).
Scheme 1
Figure imgf000119_0001
Figure imgf000119_0002
(R3 = -NR5R6) A variation of the above method is illustrated in Scheme 2. The protected amino ester V may be first hydrolyzed to the carboxylic acid VIII, for example by treatment with aqueous base, followed by the coupling reaction with the desired amine as described above to provide IX. This may then be followed by removal of the protected amine as described above and reaction with the desired sulfonyl chloride to provide the desired compound of formula (I) (R3 = -NR5R6).
Scheme 2
Figure imgf000120_0001
(R3 = -NR5R6)
An alternative method to obtain compounds of formula (I) (R3 = NR R ) is illustrated in Scheme 3. Aminobutyrolactone may be first protected with an amine protecting group such a Boc group as described above, followed by treatment with the desired amine HNR R while heating to provide the amide X. Intermediate X may be treated with a chlorinating agent such as PS-PPI13 in CCl4 to provide XI, followed by treatment with the salt of the desired heterocycle in a suitable solvent such as DMF to provide XII. Alternatively, XII may be formed directly by treatment of X with DEAD, PPh3, a suitable amine such as Et3N and the desired heterocycle. The Boc protecting group may then be removed from XII as described above, followed by reaction of the resulting amine with a sulfonyl chloride bearing R1 as described above to provide the desired compound of formula (I) (R3 = -NR R ).
Scheme 3
Figure imgf000121_0001
The R > l ScO2CI intermediates used in the above schemes may be prepared by methods known in the art, for example by treatment of R1 with chlorosulfonic acid, by treatment of R1Br with J-BuLi followed by SO2 and N-chlorosuccinimide or SO2CI2, or by treatment of R1NH2 with NaNO2 followed by CuCl or CuCl2 and SO2 or SO3H2 in acetic acid.
A method to prepare compounds of formula (I) (R = cycloalkyl) is illustrated in Scheme 4. Intermediate XIII may be prepared from Intermediate VIII by the coupling reaction with the N-methyl methoxylamine as described above to provide Intermediate XIII. Intermediate XIII may be treated with a cycloalkyl Grignard reagent to provide the desired compound of formula (I) (R3 = cycloalkyl). Scheme 4
Figure imgf000122_0001
XIII I (R3 = cycloalkyl)
An additional method that may be used to prepare compounds of formula (I) is illustrated in Scheme 5. Treatment of a 3-halopropionaldehyde dialkylacetal (XIV) with a salt of the desired heterocycle bearing R4, in a suitable solvent such as DMF provides XV. Alternatively, XV may be formed by reaction of XIV with the desired heterocycle in the presence of DEAD, PPI13, and a suitable amine such as triethylamine. If R4 is H, it may be converted to a halogen by treatment with an alkyl lithium reagent such as «-BuLi, followed by treatment with an electrophilic halogenating agent such as hexachloroethane or bromine. The acetal may be removed with aqueous acid to provide XVI, which may in turn undergo a Strecker reaction to provide XVII, for example, by treatment with TMSCN, Znl2, and ammonia. Compound V may then be prepared by hydrolysis of the nitrile of XVII, for example in 6 N HCl, followed by esterification, for example with EDC, HOBt, and MeOH, and then by treatment with BOC2O. Intermediate V may be used to prepare compounds of formula (I) as illustrated in Scheme 1.
Scheme 5
Figure imgf000123_0001
XIV XV XVI
(R = alkyl)
Figure imgf000123_0002
XVII
Synthetic Examples Abbreviations:
Boc ferz-butyloxycarbonyl dba dibenzylideneacetone
DCE dichloroethane
DMAP 4-(dimethylamino)pyridine
DMA dimethylacetamide
DMF dimethylformamide dppf 1,1' -bisdiphenylphosphinoferrocene
EDC l-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
HATU O-(-7-azabenzotriazol-l-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate HOBt 1 -hydroxybenzotriazole
MeCN acetonitrile
MP- macroporous polystyrene support
NBS N-bromosuccinimide
NCS N-chlorosuccinimide
NMM N-methyl morpholine
PS- gel-form polystyrene support rt room temperature
TFA trifluoroacetic acid
TMS trimethylsilyl
1-001: 4-amino-3,5-dichlorosulfonyl chloride.
Figure imgf000124_0001
To 43 mL of stirring chlorosulfonic acid (640 mmol) at 20 0C is added 26 g (160 mmol) of 2,6-dichloroaniline at such a rate that the reaction temperature does not exceed 40 0C. When the addition is complete, the mixture is heated at 120 9C for 1 hour, and then cooled to rt. The viscous liquid is poured slowly into 200 mL of stirring ice water immersed in an ice/water bath. The resulting solid is filtered, sucked dry, and then is washed with ice-cold water and cold hexanes. The mixture is dried in an oven overnight to provide 1-001 as a light-gray powder. 1-002: 3-amino-2,4-dimethylsulfonyl chloride is prepared from 2,6-dimethylaniline in the same manner as 1-001, with purification by flash chromatography (0-75% EtOAc in hexanes).
1-003: 2-oxo-2,3-dihydro-lH-indole-5-sulfonyl chloride
Figure imgf000125_0001
Oxindole (2.0 g, 15 mmol) is added slowly to 5.0 mL (75 mmol) of chlorosulfonic acid at 0 °C. The mixture is stirred at 0 °C until gas evolution slows. The mixture is warmed first to rt, then to 50 9C until the gas evolution stops (40 min). The mixture is cooled to rt, then poured over chipped ice. The resulting precipitate is filtered and washed with cold water and hexanes, and then dried to provide 3.0 g (86%) of 1-003.
1-004: 3-chloro-lH-indazole-5-sulfonyl chloride and 1-005: 3-chloro-lH-indazole-7- sulfonyl chloride
Figure imgf000125_0002
3-Chloroindazole (0.50 g, 3.3 mmol) is added slowly to 1.1 mL (16 mmol) of chlorosulfonic acid at 0 °C. The mixture is stirred at 0 0C until gas evolution slows. The mixture is warmed first to rt, then to 50 °C for 2h. The mixture is cooled to rt, then poured over chipped ice. The resulting mixture is extracted twice with 5% MeCN in CH2Cl2, and the combined extracts are washed with water and brine, dried over Na2SO4, filtered and concentrated to provide 640 mg (77%) of a 1 :1 mixture of 1-004 and 1-005. 1-006: 2,5,6-trimethyl-3H-benzimidazole-4-sulfonyl chloride
2,5,6-Trimethylbenzimidazole (0.5 g, 3.1 mmol) is added slowly to 1.0 mL (15 mmol) of chlorosulfonic acid at 0 °C. The mixture is stirred at 0 0C until the gas evolution slows. The mixture is warmed first to rt, then to 50 °C for 2h. The mixture is cooled to rt, then poured into CH2CI2. Ice water is slowly added, and the phases are separated. The aqueous phase is washed with CH2CI2, and the combined extracts are washed with water and brine, dried over Na2SO4, filtered, and concentrated to provide 68 mg of a gray solid containing 53% 1-006, and 47% of a non-reactive unknown by-product (5% yield).
1-007: lH-indole-6-sulfonyl chloride
Figure imgf000126_0002
To a solution of 2.4 g (12 mmol) of 6-bromoindole in 20 mL of TΗF and 20 mL of Et2O at 0 9C is added 500 mg (12 mmol) of 60% NaH in mineral oil. After stirring for 15 min, the mixture is cooled to -78 9C, and 14 mL (24 mmol) of 1.7 M t-BuLi in pentane is added slowly. After 30 min, 8.0 mL (24 mmol) of a 19% solution of SO2 in THF is slowly added. The mixture is then allowed to warm to rt overnight. To the resulting solid is added 30 mL of Et2O and 0.76 mL (13 mmol) of glacial acetic acid. The mixture is stirred for 30 min at 0 °C, and then is filtered and quickly washed with Et2O. The solids are then suspended in 30 mL of Et2O, chilled to 0 9C, and 1.7g (12 mmol) of NCS is carefully added. The resulting suspension is stirred rapidly for 30 min, and then is filtered and washed with Et2O. The filtrate and washes are concentrated to provide 1.8 g (70%) of 1-007 as a brown crystalline solid.
1-008: lH-indole-4-sulfonyl chloride is prepared from 4-bromoindole in the same manner as 1-007.
1-009: 7-methyl-lH-indole-4-sulfonyl chloride is prepared from 4-bromo-7-methylindole in the same manner as 1-007.
1-010: 2-dimethylcarbamoyl-lH-indole-4-sulfonyl chloride is prepared from 4-bromo-lH- indole-2-carboxylic acid dimethylamide in the same manner as 1-007
1-011: 4-bromo-5-chloro-indole-l-carboxylic acid tert-butyl ester and 1-012: 6-bromo-5- chloro-indole-1-carboxylic acid tert-butyl ester
Figure imgf000127_0001
A 1.0 M solution of vinylmagnesium bromide in TΗF (0.13 L, 130 mmol) is added slowly to 10 g (43 mmol) of 3-bromo-4-chloro-nitrobenzene in 140 mL of TΗF at -40 °C. The mixture is stirred at -40 C for an additional hour when aqueous NH4Cl is added. The mixture is allowed to warm to rt, and then is extracted with EtOAc. The extract is washed with brine, dried over MgSO4, filtered, concentrated, and purified twice by chromatography (33% EtOAc in hexanes) to provide 0.95 g (9.7%) of 4-bromo-5-chloro-lH-indole and 0.77 g (7.9%) of 6- bromo-5-chloro-lH-indole. Each of the indole products is separately treated with 1.1 equivalents of BoC2O and 0.2 equivalents of DMAP in MeCN. The mixtures are concentrated and the residues chromatographed (10% EtOAc in hexanes) to provide 1-011 (32%) and 1-012 (48%).
1-013: 4-bromo-5-fluoro-indole-l-carboxylic acid tert-butyl ester and 1-014: 5-bromo-6- fluoro-indole-1-carboxylic acid tert-butyl ester are prepared from 3-bromo-4- fluoro-nitrobenzene in the same manner as 1-011.
1-015: 7-bromo-indole-l-carboxylic acid tert-butyl ester
Figure imgf000128_0001
A solution of 0.35 g (1.8 mmol) of 7-bromoindole, 0.43 g (2.0 mmol) of BOC2O, and 44 mg (0.36 mmol) of DMAP in 4 mL of MeCN is stirred for 1 h, and then EtOAc is added. The mixture is washed with water and brine, dried over MgSO4, filtered, concentrated, and purified by flash chromatography (10% EtOAc in hexanes) to provide 0.20 g (38 %) of 1-015.
1-016: indol-5-yl sulfonyl chloride
Figure imgf000128_0002
To a solution of 5-bromoindole in 5ml of Et2O at -78 9C is added 2.2 mL of 1.7 M J-BuLi (3.7 mmol). After stirring for 40 min, the reaction is warmed to 0 0C for 5 min then cooled to -78 0C. Sulfur dioxide is bubbled through the solution for 5 min, and then the mixture is allowed to warm to rt and stirred overnight. To this is added 0.64 g (4.8 mmol) of NCS. After stirring for 1.5 h, the mixture is filtered and the precipitate is washed with Et2O. The filtrate is concentrated to provide 0.27 mg (78%) of 1-016.
1-017: T-chlorosulfonyl-indole-l-carboxylic acid tert-butyl ester is prepared from 1-015 in the same manner as 1-016.
1-018: l-triisopropylsilanyl-lH-indole-3-sulfonyl chloride is prepared from 3-bromo-l- triisopropylsilanyl-lH-indole in the same manner as 1-016.
1-019: 3-chlorosulfonyl-2-methyl-indole-l-carboxylic acid tert-butyl ester is prepared from 3-bromo-2-methyl-indole-l-carboxylic acid tert -butyl ester (SynChem) in the same manner as 1-016.
1-020: lH-indazole-4-sulfonyl chloride is prepared from 4-bromo-lH-indazole in the same manner as 1-016 with purification by flash chromatography.
1-021: 4-chlorosulfonyl-5-fluoro-indole-l-carboxylic acid tert-butyl ester is prepared from 1-013 in the same manner as 1-016, but is used in situ without isolation.
1-022: δ-chlorosulfonyl-S-fluoro-indole-l-carboxylic acid tert-butyl ester is prepared from 1-014 in the same manner as 1-016, but is used in situ without isolation.
1-023: 5-chloro-4-chlorosulfonyl-indole-l-carboxylic acid tert-butyl ester is prepared from 1-011 in the same manner as 1-016, but is used in situ without isolation. 1-024: 5-chloro-6-chlorosulfonyl-indole-l-carboxylic acid tert-butyl ester is prepared from 1-012 in the same manner as 1-016, but is used in situ without isolation.
1-025: lH-indazole-6-sulfonyl chloride
Figure imgf000130_0001
A solution of 3.8 g (55 mmol) of NaNU2 in 5 mL of water is added to 6.7 g (50 mmol) of 6- aminoindazole in 15 mL of concentrated HCl and 5 mL of glacial acetic acid at -10 0C is added at such a rate that the temperature does not exceed -5 0C. After stirring for 30 min, a solution of 1.2 g (13 mmol) of CuCl in 50 mL of saturated SO2 in acetic acid is added over 10 minutes. The mixture is warmed to rt and stirred until N2 evolution ceases. The mixture is poured onto ice and the resulting precipitate is filtered, and then is suspended in EtOAc (150 mL) and washed with NaHCCb and brine, dried over MgSO4, filtered, and concentrated to provide 2.5 g (23%) of 1-025 as a yellow solid.
1-026: 7-azaindol-4-yl sulfonyl chloride and 1-027: 3-bromo-7-azaindol-4-yl sulfonyl chloride
Figure imgf000130_0002
Methanesulfonic acid anhydride (13 g, 73 mmol) is added to 6.1 g (37 mmol) of 7-azaindole- 7-oxide (/. Org. Chem, 1980, 45, 4045) oxide and 8.5 g (55 mmol) of Me4NBr in 50 mL of DMF at 0 0C. The suspension is allowed to warm as it stirs for 12 h. The mixture is poured into water and 50% NaOH solution is added to bring the pH to 7. The solution is chilled to 0 °C for 30 minutes, and the precipitate filtered, washed with cold water, and dissolved in CH2Cl2/Me0H (10:1). This solution is dried over MgSO4, filtered and concentrated to provide 2.4 g of a mixture of 4-bromo-7-azaindole and 3,4-dibromo-7-azaindole. This mixture is treated with J-BuLi, SO2, and NCS just as in the synthesis of 1-016 to access a mixture of 1-026 and 1-027.
1-028: 4-chlorosulfonyl-l-(2-trimethylsilanyl-ethoxymethyl)-lH-indole-7-carboxylic acid
Figure imgf000131_0001
To a solution of 0.54 g (1.0 mmol) of 4,7-dibromo-l-(2-trimethylsilanyl-ethoxymethyl)-lH- indole (Li, L. et al Tetrahedron Lett., 2003, 44, 5987) in 5 mL of TΗF at -78 0C is added 1.4 mL (2.3 mmol) of 1.7 M J-BuLi in hexanes. After stirring for 20 min, 0.088 g (2.0 mmol) of solid CO2 is added. After stirring for Ih, excess CO2 is removed in vacuo and then 1.3 mL (2.2 mmol) of /-BuLi is added at -78 0C. After stirring for 15 min, SO2 is bubbled through the solution for 10 min. The mixture is warmed to 0 °C over 2h and 0.64 (4.8 mmol) of NCS is added and the mixture is stirred for 12 h. Both EtOAc and water are added, followed by enough saturated Na2Sθ3 solution to bring the pΗ to 5. The layers are separated, and the aqueous phase is extracted three times with EtOAc. The combined extracts are dried over MgSO4, filtered, and concentrated to provide 0.38 g (12%) of 1-028 as a black solid.
1-029: 2-bromo-6-methylbenzenesulfonyl chloride
Figure imgf000131_0002
To a solution of 0.20 g (1.1 mmol) of 2-bromo-6-methylaniline in 2 mL of acetic acid is added 0.20 mL of concentrated HCl. A solution of 74 mg (1.1 mmol) of NaNO2 in 0.20 mL of water is added at 0 0C. After stirring for 1 h, 0.5 mL of acetic acid, 0.35 mL of sulfurous acid, and 31 mg (0.32 mmol) of CuCl are added. The mixture is stirred overnight, and then is poured onto ice-water. The mixture is extracted with EtOAc, washed with brine, dried over MgSO4, filtered, and concentrated to provide 81 mg (28%) of 1-029.
1-030: l,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid hydrochloride
Figure imgf000132_0001
A solution of 1.2 g (4.4 mmol) of 2-acetyl-7-chlorosulphonyl-l,2,3,4-tetrahydroiso-quinoline (Pendelton, R. G., et al. J. Pharmacol. Exp. Ther., 1979, 2OS, 24) in 20 mL of EtOH is stirred at rt for 2 days, then concentrated. The residue is stirred in 15 mL of 10% HCl at 100 0C in a pressure tube for 12 h, then cooled and concentrated. The residue is azeotroped to dryness with EtOH, and then recrystallized from EtOH to provide 0.63 g (58%) of 1-030 as white crystals.
1-031: 3-((αs)-4-methyl-piperidin-3-yl)-propionic acid ethyl ester
Figure imgf000132_0002
A mixture of 2.0 g (12 mmol) of 3-bromo-4-methylpyridine, 2.5 mL of CH3CN, 3.2 mL (23 mmol) of Et3N, 5.8 g (58 mmol) of ethyl acrylate, and 0.095 g (0.12 mmol) of PdCl2(dppf)-CH2Cl2 is stirred in an evacuated and sealed pressure tube at 125 0C for Ih. The mixture is concentrated and purified by flash chromatography (5-60 % EtOAc in hexanes) to provide 1.0 g (47 %) of (E)-3-(4-methyl-pyridin-3-yl)-acrylic acid ethyl ester as a dark oil. This material is stirred in 2 mL of toluene with 0.70 mL (6.0 mmol) of benzyl bromide at 60 0C overnight. The resulting precipitate is filtered and washed with toluene to provide 1.4 g (4.0 mmol) of the benzyl pyridinium bromide as a white powder. To this material in 20 mL of EtOH at 0 0C is added 0.30 g (8.0 mmol) of NaBH4 in portions over 30 minutes. The mixture is stirred for 90 min, concentrated by half, dissolved in CH2CI2, washed twice with water and once with brine, dried over Na2SO4, filtered, and concentrated. Flash chromatography (5-50% EtOAc in hexanes) provides 0.42 g (1.5 mmol) of (E)-3-(l-benzyl- 4-methyl-l,2,5,6-tetrahydro-pyridin-3-yl)-acrylic acid ethyl ester as a yellow oil. This material is stirred in 3 mL of EtOH with 42 mg of Pd/C under an H2 atmosphere overnight. The vessel is evacuated with N2, filtered through diatomaceous earth, and concentrated to provide 208 mg of 1-031 as a yellow oil.
1-032: (£>3-piperidin-3-yl-acrylic acid methyl ester hydrochloride
Figure imgf000133_0001
Diethyl [l-(methoxycarbonyl)methyl]phosphonate (1.8 mL, 9.8 mmol) is added to 0.38g (9.4 mmol) of 60% NaH in mineral oil stirring in 36 mL of toluene at 0 °C. After 1 h, 1.Og (4.7 mmol) of N-Boc-piperidine-3-carbaldehyde is added. After stirring for Ih at 0 °C, aqueous saturated NH4Cl is added, and the mixture is extracted with ether. The extract is dried over MgSO4, filtered, and concentrated. Chromatography (10-70% EtOAc in hexanes) provides 0.75 g of a colorless oil. This material (0.25 g, 0.93 mmol) is stirred in 0.5 mL of 4M HCl in 1,4-dioxane for Ih. The mixture is concentrated to provide 0.16 g (83%) of 1-032.
1-033: 4-methyl-l,2,3,6-tetrahydro-pyridine hydrochloride ClH HN.
A mixture of 0.10 g (0.53 mmol) of l-benzyl-4-methyl-l,2,3,6-tetrahydro-pyridine (Bonin, M. et al. J. Org. Chem, 1984, 49, 2392) and 0.061 mL (0.053 mmol) of 1-chloroethyl chloroformate in 0.5 mL of dichloroethane is stirred at 80 °C overnight. The mixture is concentrated and taken up in 1 mL of MeOH. The mixture is heated at 60 9C for 6 h, and then cooled. This material is dissolved in aqueous HCl, extracted twice with Et2O, and lyopholized to provide 1-033 as an orange foam.
1-034: (frγms)-3-hydroxy-4-methyl-piperidine hydrochloride
ClHHW rγ KOH
To a solution of 0.10 g (0.49 mmol) of ?ra«s-4-methyl-l-(phenylmethyl)-3-piperidinol (Brown Ripin, D. H., et al Tetrahedron Lett. 2000, 5817) in 1 mL of DCE at 0 °C is added 0.12 mL (1.1 mmol) of 2-chloroethyl-chloroformate. The mixture is warmed to 80 °C and stirred for 12 h. The mixture is concentrated, and then dissolved in 2 mL of MeOH and heated to 60 °C for 6h. The mixture is dissolved in 1 mL of IN HCl and extracted twice with Et2O. The aqueous phase is then lyophilized to provide 40 mg of an orange oil composed of 1-034 and unreacted benzylamine in a 1 : 1 ratio.
1-035: l,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid methylamide trifluoroacetate
Figure imgf000134_0001
A solution of 0.20 g (0.72 mmol) of N-Boc-l,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid (ASW MedChem), 0.28 g (1.4 mmol) of EDC, and 0.19 (1.4 mmol) of HOBt hydrate is stirred in 2 mL of DMF for 30 min when 3.6 mL (7.2 mmol) of methylamine (2.0 M in THF) is added. The mixture is stirred at 80 9C for 5 h, and then is diluted with EtOAc and washed twice with water and twice with brine. The extract is dried over Na2SO4, filtered, and concentrated. This material is stirred in 1.5 mL of 33% TFA in CH2Cl2 for 2h, and then concentrated to provide 1-035.
1-036: l,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid dimethylamide is prepared from N-Boc-l^^^-tetrahydro-isoquinoline-T-carboxylic acid and dimethylamine hydrochloride (with 5 equivalents of Et3N) in the same manner as 1-035.
1-037: morpholin-4-yl-(l,2,3,4-tetrahydro-isoquinolin-7-yl)-methanone is prepared from N-Boc-l,2,3,4-tetrahydro-isoquinoline-7-carboxylic acid and morpholine in the same manner as 1-035.
1-038: (l,2,3,4-tetrahydro-isoquinolin-6-yloxy)-acetic acid methyl ester
Figure imgf000135_0001
A mixture of 0.45 g (2.0 mmol) of 6-hydroxyl-l,2,3,4-tetrahydroisoquinoline hydrobromide and 0.92 mL (6.5 mmol) of Et3N in 5 mL of MeOH is treated with 0.71 (3.3 mmol) of BoC2O. After stirring for Ih, the mixture is concentrated, dissolved in EtOAc, and washed with water, IN HCl, NaHCO3, and brine. The solution is dried over MgSO4, filtered, concentrated, and purified by flash chromatography (10-50% EtOAc in hexanes) to provide 0.40 g (83%) of a colorless oil. This material (0.14 g, 0.55 mmol), 0.13 (0.82 mmol) of methyl bromoacetate, and 0.11 g (0.82 mmol) of K2CO3 are stirred in 0.5 mL of DMF for 12 h. Water is added, and the mixture is extracted twice with EtOAc. The extracts are dried over MgSO4, filtered, concentrated, and purified by flash chromatography (40% EtOAc in hexanes) to provide 0.12 g (67%) of a yellow oil. This material is stirred in 2 mL of 4N HCl in 1,4-dioxane for 3h, then concentrated. The residue is dissolved NaHCO3 and extracted twice with EtOAc. The extracts are washed with brine, dried over MgSO4, filtered, and concentrated to provide 68 mg (90%) of 1-038.
1-039: 2-methyl-2-(l,2,3,4-tetrahydro-isoquinolin-7-yloxy)-propionic acid ethyl ester
Figure imgf000136_0001
A mixture of 1.0 g (6. 8 mmol) of 7-hydroxyisoquinoline, 6.0 g (30 mmol) of ethyl bromoisobutyrate, and 4.2 g (30 mmol) of K2CO3 in 14 mL of DMF is heated to 95 9C under N2 for 18 hrs. The reaction is diluted with water and extracted twice with EtOAc. The extracts are dried over MgSO4, filtered, and concentrated. Chromatography (40% EtOAc in hexanes) provides 1.8 g (>99%) of a yellow oil. This material (0.47 g, 1.8 mmol) is stirred over 21 mg of Pt2O-H2O in 10 mL of HOAc under 50 psi of H2 for 18 h. The mixture is filtered, and the filtrate is dissolved in EtOAc and extracted with NaOH. The basic wash is extracted twice with EtOAc and the combined extracts are washed with brine, dried over MgSO4, filtered, and concentrated to provide 0.48 (99%) of 1-039..
1-040: [3-hydroxy-l-(4-methyl-piperidine-l-carbonyl)-propyl]-carbamic acid tert-bntyl ester
Figure imgf000136_0002
To 25.6 g (141 mmol) of 2-amino-γ-butyrolactone in 200 mL of CH2Cl2 is added 32.2 g (157 mmol) of Boc2O. Triethylamine (40 mL, 290 mmol) is then added in two portions, and the mixture is stirred for 48h. The mixture is washed with water, 1 M NaHSO4, and brine, and then dried with Na2SO4, filtered, and concentrated to provide 26.8 g (95%) of (2-oxo- tetrahydro-furan-3-yl)-carbamic acid tert-butyl ester as a white solid. This material (14.6 g, 72.6 mmol), 17.5 mL of 4-methylpiperidine, and 17.5 mL of 1,4-dioxane are sealed in a pressure tube and heated to 120 °C for 30 min. After cooling, the mixture is dissolved in EtOAc and washed with water, 1 M NaHSO4, and brine, and then it is dried with Na2SO4, filtered, and concentrated to provide a white solid. Recrystallization from hexanes provides 21.3 g (98%) of 1-040.
1-041: [3-chloro-l-(4-methyl-piperidine-l-carbonyl)-propyl]-carbamic acid tert-butyl ester
Figure imgf000137_0001
To 300 mg (1.0 mmol) 1-040 in 5.0 mL of CCl4 and 5.0 mL of CH2Cl2 is added 1.0 g (3.0 mmol) of PS-PPh3. The mixture is shaken overnight, and then the resin is filtered and washed with CH2Cl2. The filtrate is concentrated, and the resulting residue is dissolved in EtOAc, filtered, and concentrated to provide 284 mg of 1-041.
1-042: 4-bromo-2-tert-butoxycarbonylamino-butyric acid methyl ester
Figure imgf000137_0002
A suspension of α-amino-γ-butyrolactone hydrobromide in 30 % HBr in HOAc is heated at 100 0C in a sealed tube for 5 days. The mixture is concentrated to give a white solid that is washed with ether to provide 23.1 g (64%) of 2-amino-4-bromo-butyric acid hydrobromide. Acetyl chloride (61 mL, 860 mmol) is added dropwise to 200 mL of MeOH at 0 °C. The mixture is stirred at rt for 30 min before 22.5 g (124 mmol) of 2-amino-4-bromo-butyric acid hydrobromide is added. The mixture is stirred overnight and concentrated. The residue is washed with ether to provide 23.5 g (82%) of methyl 4-bromo-2-amino-butyrate hydrochloride. A solution of 27.7g (330 mmol) of NaHCθ3 in 100 mL of water is slowly added to 19.2 g (82.5 mmol) of this material along with 21.6 g (99.0 mmol) of BoC2O in 140 mL of 1,4-dioxane at 0 0C,. The mixture is warmed to rt and stirred overnight. N,N-dimethyl propane-l,3-diamine (5 mL) is added to the mixture, and it is stirred for 20 min. The mixture is diluted with water then extracted twice with EtOAc. The extracts are washed with water, IM NaHSO4, and brine, and then combined, dried with Na2SO4, filtered, and concentrated to provide 21.5 g (88%) of 1-042 as a white solid.
1-043: 2-ter^butoxycarbonylamino-4-(2-chloro-imidazol-l-yl)-butyric acid methyl ester
Figure imgf000138_0001
To a solution of 0.87 g (8.4 mmol) of 2-chloroimidazole in 14 mL of DMF is added 0.40 g (10 mmol) of 60% NaH in mineral oil. After 20 min of stirring, 2.5 g (8.4 mmol) of 1-042 in 5 mL of DMF is added. The reaction mixture is heated to 80 0C for 1 h. The mixture is diluted with EtOAc (150 mL), washed with water, brine, dried over MgSO4, filtered, and concentrated. The residue is purfied by flash chromatography (0-5% MeOH in CH2CI2) to provide 2.1 g (78%) of 1-043.
1-044: 2-tert-butoxycarbonylamino-4-(2-cyano-pyrrol-l-yl)-butyric acid methyl ester is prepared from pyrrole-2-carbonitrile and 1-042 in the same manner as 1-043.
1-045: 2-tert-butoxycarbonylamino-4-(2-nitro-imidazol-l-yl)-butyric acid methyl ester is prepared from 2-nitroimidazole and 1-042 in the same manner as 1-043.
1-046: 2-tert-butoxycarbonylamino-4-l,2,3-triazol-2-yl-butyric acid methyl ester is prepared from 1,2,3-triazole and 1-042 in the same manner as 1-043, with chromoatographic separation from the 1 -triazolyl isomer .
1-047: 2-tert-butoxycarbonylamino-4-pyrazol-l-yl-butyric acid methyl ester is prepared from pyrazole and 1-042 in the same manner as 1-043.
1-048: 2-fert-butoxycarbonylamino-4-(2-chloro-imidazol-l-yl)-butyric acid
Figure imgf000139_0001
A mixture of 0.50 g (1.6 mmol) of 1-043 in 12 mL of MeOH and 3.1 mL (6. 2 mmol) of 2 M aq. NaOH is stirred for 60 min, and then concentrated by 1/3 and diluted with saturated aqueous NH4Cl. After adjusting the pH to 4 with HCl, the mixture is extracted with CH2Cl2 (3x) and the extracts are washed with brine, then dried with Na2SO4, filtered, and concentrated to provide 0.42 g (87%) of 1-048 as a white solid. 1-049: 2-tert-butoxycarbonylamino-4-pyrazol-l-yl-butyric acid is prepared from 1-047 in the same manner as 1-048.
1-050: 2-tert-butoxycarbonylamino-4-(2-cyano-pyrrol-l-yl)-butyric acid is prepared from 1-044 in the same manner as 1-048.
1-051: 2-ter^butoxycarbonylamino-4-(2-nitro-imidazol-l-yl)-butyric acid is prepared from 1-045 in the same manner as 1-048.
1-052: 2-tert-butoxycarbonylamino-4-l,2,3-triazol-2-yl-butyric acid is prepared from I- 046 in the same manner as 1-048.
1-053: l-(3,3-dimethoxy-propyl)-lH-pyrazole
Figure imgf000140_0001
To a solution of 1.7 g (25 mmol) of pyrazole in 15 mL of DMF is added 0.98 g (25 mmol) of 60% NaH in mineral oil. After stirring for 15 min, 5.0 g (25 mmol) of 3- bromopropionaldehyde dimethylacetal is added. The mixture is heated to 160 0C for 3h, then cooled and diluted 20 mL of EtOAc. The mixture is washed with water and brine, dried over MgSO4, filtered, and concentrated. Flash chromatography (0-5% MeOH in CH2CI2) provides 3.2 g (72%) of 1-053 as a colorless oil.
1-054: 4-(5-chloro-pyrazol-l-yl)-2-tert-butoxycarbonylamino-butyric acid
Figure imgf000141_0001
A 2.5 M solution of BuLi (4.2 mL, 11 mmol) is added slowly to a stirring solution of 1.5 g (8.8 mmol) of 1-053 in 50 mL of THF at -78 9C. The mixture is stirred for 30 min, and then hexachloroethane (2.3 g, 9.7 mmol) is slowly added. The mixture allowed to come to rt and stirred overnight. Saturated Na2CCh (50 mL) is added, and the mixture is extracted with EtOAc. The extract is washed with water and brine, dried over MgSO4, filtered, and concentrated. Flash chromatography (0-75% EtOAc in hexanes) provides 1.0 g (55%) of 5- chloro-l-(3,3-dimethoxy-propyl)-lH-pyrazole. To 1.9 g (9.5 mmol) of this material in 10 mL of TΗF at 0 9C is added a solution of 6.0 mL (16 mmol) of 70% HClO4 in 15 mL of THF. Water (5 ml) is subsequently added, and the mixture is stirred for 1 h. The mixture is poured into saturated NaHCθ3 and extracted with EtOAc. The extract is washed with brine, dried over MgSO4, filtered, and concentrated to provide 1.4 g (93%) of 3-(5-chloro-pyrazol-l-yl)- propionaldehyde. To a mixture of 1.4 g (8.8 mmol) of this material and 1.5 mL (11 mmol) of TMSCN in 4 ml of THF is added ~1 mg of ZnI2. After stirring for 15 min, a solution of 7M NH3 in MeOH (8 ml) is added. The mixture is sealed in a pressure tube and heated to 40 °C for 2h. The mixture is cooled and concentrated to provide 1.3 g (81%) of crude 2-amino-4-(5- chloro-pyrazol-l-yl)-butyronitrile. A mixture of 1.2 g (6.5 mmol) of this material in 4 mL of concentrated HCl is heated to reflux for 12 h. The mixture is cooled and neutralized with saturated. NaHCθ3. After adding 50 ml of water and 50 ml dioxane, 7.1 g (33 mmol) of Boc2O is added. The mixture is stirred overnight and extracted with EtOAc. The aqueous phase is acidified to pH 4 with IN HCl, and extracted with EtOAc. This extract is washed with brine, dried over MgSO4, filtered, and concentrated to provide 1.7 g (86%) of 1-054. 1-055: 4-(5-bromo-pyrazol-l-yl)-2-tert-butoxycarbonylamino-butyric acid is prepared from 1-053 in the same manner as 1-054 by substituting Br2 for hexachloroethane.
1-056: 2-tert-butoxycarbonylamino-4-(5-carbamoyl-pyrazol-l-yl)-butyric acid
Figure imgf000142_0001
A mixture of 0.78 g (2.2 mmol) of 1-055, 0.52 g (2.7 mmol) of EDC, 0.36 g (2.7 mmol) of HOBt, and 5 mg of DMAP in 3 mL of DMF is stirred for 5 min, and then 86 mg of MeOH is added. The mixture is stirred for 4h, then diluted with EtOAc, washed with water and brine, dried over MgSO4, filtered, and concentrated. Preparative HPLC provides 0.58 g (71%) of 2- fer/-butoxycarbonylamino-4-(5-bromo-pyrazol-l-yl)-butyric acid methyl ester. A mixture of 0.35 g (0.97 mmol) of this material, 35 mg (0.038 mmol) of Pd2(dba)3, 43 mg (0.077 mmol) of dppf, 110 mg (0.97 mmol) of Zn(CN)2, and 15 mg (0.23 mmol) of Zn powder in 2 mL of DMA is heated to 120 °C for 5h in a pressure tube. The mixture is cooled, filtered, and purified directly on preparative HPLC to provide 0.13 g (44%) of 2-tert- butoxycarbonylamino-4-(5-cyano-pyrazol-l-yl)-butyric acid methyl ester. This material is dissolved in 2.5 mL of MeOH and 2.5 mL of IM NaOH is added. After stirring for 3 h, the mixture is neutralized with 6N HCl and extracted with EtOAc (3 x 15 mL). The extracts are washed with water and brine, dried over MgSO4, filtered, and concentrated to provide a small amount of product. Lyophilization of the aqueous washes provides 110 mg (84%) of 1-056 contaminated with NaCl.
1-057: 2-amino-l-(4-methyl-piperidin-l-yl)-4-(2-nitro-imidazol-l-yl)-butan-l-one hydrochloride
Figure imgf000143_0001
A mixture of 320 mg (1.0 mmol) of 1-051 and 290 mg (2.1 mmol) of HOBt is dissolved inl mL of DMF, and then 0.32 g (1.6 mmol) of EDC is added. After stirring for 20 min., 0.36 mL (3.0 mmol) of 4-methylpiperidine is added. The mixture is stirred overnight, diluted with EtOAc, and washed twice with water and once with brine. It is then dried with Na2SO4, filtered, and concentrated. Flash chromatography (2-5% MeOH in CH2Cl2) provides 400 mg (75%) of [l-(4-methyl-piperidine-l-carbonyl)-3-(2-nitro-imidazol-l-yl)-propyl]-carbamic acid tert-butyl ester as a pale yellow oil. A solution of 0.37 g (0.94 mmol) of this material in 10 mL of 4 M HCl in 1,4-dioxane is stirred for 10 min, and then is concentrated to provide 0.27 g (98%) of 1-057 as a yellow solid.
1-058 - 1-082 are prepared in the same manner as 1-057.
1-058: 2-amino-l-piperidin-l-yl-4-pyrazol-l-yl-butan-l-one dihydrochloride from 1-049 and piperidine.
1-059: 2-amino-l-(4-hydroxymethyl-piperidin-l-yl)-4-pyrazol-l-yl-butan-l-one dihydrochloride from 1-049 and 4-hydroxymethylpiperidine.
1-060: 2-amino-l-(3,4-dihydro-lH-isoquinolin-2-yl)-4-(2-nitro-imidazol-l-yl)-butan-l- one hydrochloride from 1-051 and tetrahydroisoquinoline. -061: 2-amino-4-(2-nitro-imidazol-l-yl)-l-(trans)-octahydro-isoquinolin-2-yl-butan-l- one hydrochloride from 1-051 and /rαws-decahydroisoquinoline. -062: 2-amino-4-(2-nitro-imidazol-l-yl)-l-(cis)-octahydro-isoquinolin-2-yl-butan-l-one hydrochloride from 1-051 and cώ-decahydroisoquinoline. -063: 2-amino-4-(2-nitro-imidazol-l-yl)-l-(4-trifluoromethyl-piperidin-l-yl)-butan-l- one hydrochloride from 1-051 and 4-trifluoromethylpiperidine. -064: 2-amino-l-(αs)-octahydroisoquinolin-2-yl-4-l,2,3-triazol-2-yl-butan-l-one hydrochloride from 1-052 and cώ-decahydroisoquinoline. -065: 2-amino-l-(4-methyl-piperidin-l-yl)-4-l,2,3-triazol-2-yl-butan-l-one hydrochloride from 1-052 and 4-methylpiperidine. -066: 2-amino-4-(2-chloro-imidazol-l-yl)-l-(4-methyl-piperidin-l-yl)-butan-l-one hydrochloride from 1-048 and 4-methylpiperidine. -067: 2-amino-4-(2-chloro-imidazol-l-yl)-l-(cis)-octahydro-isoquinolin-2-yl-butan-l- one hydrochloride from 1-048 and cώ-decahydroisoquinoline. -068: 2-amino-4-(2-chloro-imidazol-l-yl)-l-(trαns)-octahydro-isoquinolin-2-yl-butan-l- one hydrochloride from 1-048 and /rarø-decahydroisoquinoline. -069: 2-amino-4-(2-chloro-imidazol-l-yl)-l-(3,4-dihydro-lH-isoquinolin-2-yl)-butan-l- one hydrochloride from 1-048 and tetrahydroisoquinoline. -070: 2-amino-4-(2-chloro-imidazol-l-yl)-l-(4-trifluoromethyl-piperidin-l-yl)-butan-l- one hydrochloride from 1-048 and 4-trifluoromethylpiperidine. -071: 2-amino-Λ^-(4-chloro-benzyl)-4-(2-cyano-pyrrol-l-yl)-Λ^-methyl-butyramide hydrochloride from 1-050 and N-methyl 4-chlorobenzylamine. -072: 2-amino-Ν-benzyl-4-(2-cyano-pyrrol-l-yl)-Ν-methyl-butyramide hydrochloride from 1-050 and N-methyl benzylamine. -073: l-(3-amino-4-oxo-4-piperidin-l-yl-butyl)-lH-pyrrole-2-carbonitrile hydrochloride from 1-050 and piperidine. -074: l-[3-amino-4-oxo-4-(4-phenyl-piperazin-l-yl)-butyl]-lH-pyrrole-2-carbonitrile dihydrochloride from 1-050 and 4-phenylpiperazine. -075: l-[3-amino-4-(4-hydroxymethyl-piperidin-l-yl)-4-oxo-butyl]-lH-pyrrole-2- carbonitrile hydrochloride from 1-050 and 4-hydroxymethylpiperidine. -076: l-(frans-3-amino-4-octahydro-isoquinolin-2-yl-4-oxo-butyl)-lH-pyrrole-2- carbonitrile hydrochloride from 1-050 and /rarø-decahydroisoquinoline. 1-077: l-P-amino^-CS^-dihydro-SH-l^^-triazolo^^-αlpyrazin^-yO^-oxo-butyll-lH- pyrrole-2-carbonitrile hydrochloride from 1-050 and 5,6,7,8-tetrahydro-l,2,4- triazolo [4, 3 -a] pyrazine.
1-078: 2-amino-4-(2-cyano-pyrrol-l-yl)-Λ^-methyl-Λ^-((R)-l-phenyl-ethyl)-butyramide hydrochloride from 1-050 and (R)-l-phenylethylamine.
1-079: 2-[3-amino-4-(4-methyl-piperidin-l-yl)-4-oxo-butyl]-2H-pyrazole-3-carboxylic acid amide hydrochloride from 1-056 and 4-methylpiperidine.
1-080: 2-amino-4-(5-bromo-pyrazol-l-yl)-l-(4-methyl-piperidin-l-yl)-butan-l-one hydrochloride from 1-055 and 4-methylpiperidine.
1-081: 2-amino-4-(5-bromo-pyrazol-l-yl)-l-(4-hydroxymethyl-piperidin-l-yl)-butan-l- one hydrochloride from 1-055 and 4-hydroxymethylpiperidine.
1-082: 2-amino-4-(5-chloro-pyrazol-l-yl)-l-(4-methyl-piperidin-l-yl)-butan-l-one hydrochloride from 1-054 and 4-methylpiperidine.
I-065a: 2-amino-l-(4-methyl-piperidin-l-yl)-4-l,2,3-triazol-2-yl-butan-l-one
Figure imgf000146_0001
1,2,3-Triazole (0.20 mL, 3.4 mmol) is added to a suspension of 150 g (3.8 mmol) of 60% NaH in mineral oil stirring in 10 mL of DMF at rt. After 15 min, a solution of 1.0 g (3.4 mmol) of 1-041 in 5 mL of DMF is added. The solution is heated to 80 °C for 2h, and then is cooled and dissolved in EtOAc. The mixture is washed twice with water and once with brine, dried with Na2SO4, filtered, and concentrated. Flash chromatography (0-5% MeOH in CH2Cl2) separates 620 g (57%) of [l-(4-methyl-piperidine-l-carbonyl)-3-l,2,3-triazol-2-yl- propyl]-carbamic acid tert-buty\ ester from the [l-(4-methyl-piperidine-l-carbonyl)-3-l,2,3- triazol-l-yl-propyl]-carbamic acid tert -butyl ester isomer. A 4M solution of HCl in 1,4- dioxane (3.7 mL, 15 mmol) is added to 620 mg (1.8 mmol) of [l-(4-methyl-piperidine-l- carbonyl)-3-l,2,3-triazol-2-yl-propyl]-carbamic acid tert-buty\ ester in 2 mL of dioxane, and the mixture is stirred overnight. The mixture is concentrated, and the residue is dissolved in 0.2 M HCl and washed with EtOAc. The pH of the aqueous layer is adjusted to 8 with NaHCθ3, and the mixture is extracted twice with EtOAc, twice with CH2Cl2, and twice with 20% iPrOH in CHCl3. The extracts are combined, dried with Na2SO4, filtered, and concentrated to provide 420 mg (81 %) of I-065a as a pale yellow oil.
1-083: l-[3-amino-4-(4-methyl-piperidin-l-yl)-4-oxo-butyl]-lH-imidazole-2-carbonitrile hydrochloride is prepared from 2-cyanoimidazole and 1-041 in the same manner as I- 065a with the omission of the aqueous workup.
1-084: 2-amino-4-(2-bromo-imidazol-l-yl)-l-(4-methyl-piperidin-l-yl)-butan-l-one hydrochloride is prepared from 2-bromoimidazole and 1-041 in the same manner as I-065a with the omission of the aqueous workup.
1-085: l-[3-amino-4-(4-methyl-piperidin-l-yl)-4-oxo-butyl]-lH-imidazole-2-carbonitrile hydrochloride is prepared from pyrazole and 1-041 in the same manner as as I-065a with the omission of the aqueous workup. 1-086: l-[3-amino-4-(4-methyl-piperidin-l-yl)-4-oxo-butyl]-lH-pyrazole-3-carbonitrile hydrochloride is prepared in a 2:1 mixture with its isomer 1-091 from 3- cyanopyrazole and 1-041 in the same manner as I-065a with the omission of the aqueous workup.
1-087: 2-amino-4-(4-chloro-pyrazol-l-yl)-l-(4-methyl-piperidin-l-yl)-butan-l-one hydrochloride is prepared in a 2:1 mixture with its isomer 1-082 from 3- chloropyrazole and 1-041 in the same manner as I-065a with the omission of the aqueous workup.
1-057: 2-amino-l-(4-methyl-piperidin-l-yl)-4-(2-nitro-imidazol-l-yl)-butan-l-one hydrochloride is prepared from 2-nitroimidazole and 1-041 in the same manner as I- 065a with the omission of the aqueous workup.
1-088: 2-amino-l-(4-methyl-piperidin-l-yl)-4-pyrrolo[2,3-Z>]pyridin-l-yl-butan-l-one hydrochloride is prepared from 7-azaindole and 1-041 in the same manner as I-065a with the omission of the aqueous workup.
1-089: l-[3-amino-4-(4-methyl-piperidin-l-yl)-4-oxo-butyl]-lH-pyrrole-2-carbonitrile hydrochloride
Figure imgf000148_0001
To 6.Og (20 mmol) of 1-040 in 100 mL of THF is added 2.8 g (30 mmol) of pyrrole-2- carbonitrile, 7.9 g (30 mmol) of PPh3, and 4.7 mL (30 mmol) of diethyl azodicarboxylate. The mixture is stirred overnight, concentrated, and purified by flash chromatography (5-50% EtOAc in hexanes) to provide 7.5 g (quantitative yield) of [3-(2-cyano-pyrrol-l-yl)-l-(4- methyl-piperidine-l-carbonyl)-propyl]-carbamic acid tert-buty\ ester. This material (4.Og, 11 mmol) is dissolved in 11 mL of 4M HCl in dioxane along with enough MeOH to complete dissolution. The mixture is stirred until a precipitate forms. The precipitate is filtered to provide 3.0 g (89%) of 1-089 as a white solid.
1-090: l-[3-amino-4-(4-methyl-piperidin-l-yl)-4-oxo-butyl]-lH-pyrrole-2-carboxylic acid methyl ester trifluoroacetate
Figure imgf000149_0001
To a solution of 87 mg (0.21 mmol) of l-[3-ferf-butoxycarbonylamino-4-(4-methyl-piperidin- l-yl)-4-oxo-butyl]-lH-pyrrole-2-carboxylic acid methyl ester (prepared from methyl pyrrole- 2-carboxylate and 1-040 in the same manner as [3-(2-cyano-pyrrol-l-yl)-l-(4-methyl- piperidine-l-carbonyl)-propyl]-carbamic acid tert-buty\ ester (see 1-089)) in 1 mL Of CH2Cl2 is added 0.08 mL of TFA. After stirring for Ih, the mixture is concentrated to provide 65 mg of 1-090.
1-091: 2-[3-amino-4-(4-methyl-piperidin-l-yl)-4-oxo-butyl]-2H-pyrazole-3-carbonitrile hydrochloride
Figure imgf000150_0001
A mixture of 0.34 g (0.79 mmol) of [3-(5-bromo-pyrazol-l-yl)-l-(4-methyl-piperidine-l- carbonyl)-propyl]-carbamic acid tert-butyl ester (prepared in the synthesis of 1-080), 31 mg (0.034 mmol) of Pd2(dba)3, 38 mg (0.069 mmol) of dppf, 96 mg (0.83 mmol) of Zn(CN)2, and 13 mg (0.20 mmol) of Zn powder in 2 mL of DMA is heated to 120 9C for 3 h in a pressure tube. The mixture is cooled, filtered, and purified directly on preparative HPLC to provide 0.22 g (74%) of [3-(5-cyano-pyrazol-l-yl)-l-(4-methyl-piperidine-l-carbonyl)- propyl]-carbamic acid tert-buty\ ester. This material is then stirred in 2.5 mL of 4 M HCl in 1,4-dioxane for Ih, and then concentrated to provide 1-091.
1-092: 2-[3-amino-4-(4-hydroxymethyl-piperidin-l-yl)-4-oxo-butyl]-2H-pyrazole-3- carbonitrile hydrochloride is prepared from [3-(5-bromo-pyrazol-l-yl)-l-(4- hydroxymethyl-piperidine-l-carbonyl)-propyl]-carbamic acid tert -butyl ester (from the synthesis of 1-081) in the same manner as 1-091.
1-093: 2-(4-amino-3,5-dichloro-benzenesulfonylamino)-4-(2-nitro-imidazol-l-yl)-butyric acid methyl ester and 1-094: 2-(4-amino-3,5-dichloro-benzenesulfonylamino)-4-(2- chloro-imidazol-l-yl)-butyric acid methyl ester
Figure imgf000150_0002
To 4.1 g (12 mmol) of 1-045 is added 31 mL (120 mmol) of 4M HCl in dioxane. After stirring for 15 min, the solution is concentrated to provide a mixture of 2-amino-4-(2-nitro- imidazol-l-yl)-butyric acid methyl ester hydrochloride and 2-amino-4-(2-nitro-imidazol-l- yl)-butyric acid methyl ester. To this mixture is added 30 ml of DMF followed by 3.4 mL (25 mmol) of Et3N and 3.2 g (12 mmol) of 4-amino-3,5-dichlorosulfonyl chloride. After stirring for 4 h, the mixture is diluted with EtOAc and washed three times with water and once with brine, and then dried with MgSO4, filtered, and concentrated. Flash chromatography (1-2% MeOH in CH2Cl2) provides 2.1 g (38%) of 1-093 and 0.70 g (13%) of 1-094.
1-095: 2-(4-amino-3,5-dichloro-benzenesulfonylamino)-4-(2-chloro-imidazol-l-yl)- butyric acid
Figure imgf000151_0001
A solution of 530 mg (1.2 mmol) of 1-094 in 5 mL of MeOH and 2.8 mL of 2 M NaOH and 1 mL of additional water is stirred overnight. The mixture is concentrated, and the pH adjusted to 6 with NH4Cl and HCl. The resulting mixture is extracted twice with 20% MeOH in CH2Cl2. The extracts are combined and concentrated. The residue is dissolved in MeOH and concentrated again to provide 0.15 g mg (28%) of 1-095.
1-096: 2-(4-Amino-3,5-dichloro-benzenesulfonylamino)-4-(2-nitro-imidazol-l-yl)-butyric acid
Figure imgf000152_0001
A solution of 1.1 g (2.4 mmol) of 1-093 in 20 mL of cone. HCl is stirred for 3h at 65 9C. The mixture is concentrated, and the residue is washed with Et2O to provide 0.88 g (85%) of I- 096 as a yellow solid.
1-097: 2-(4-Amino-3,5-dichloro-benzenesulfonylamino)-4-l,2,3-triazol-2-yl-butyric acid
Figure imgf000152_0002
A mixture of 1.0 g (3.6 mmol) of 1-046 in 4.5 mL of 4M HCl in 1,4-dioxane is stirred for Ih, and then is concentrated. The residue is dissolved in MeOH and CH2Cl2 and concentrated again. The residue is dissolved in 10 mL of DMF, and 0.94 g (3.6 mmol) 1-001 and 1.3 mL (7.2 mmol) of /Pr2NEt are added. After stirring for 3 h, the mixture is diluted with EtOAc (150 mL), washed with water (30 mL x 3) and brine, dried over MgSO4, filtered, and concentrated. Flash chromatography (2-5% MeOH in CH2Cl2) provides 1.2 g (85%) of 2-(4- amino-3,5-dichloro-benzenesulfonylamino)-4-l,2,3-triazol-2-yl-butyric acid methyl ester as a white solid. A mixture of 1.1 g (2.7 mmol) of this material in 20 mL of cone. HCl is heated to 65 0C for 3h. The reaction mixture is concentrated to provide 1.0 g (93%) of 1-097.
1-098: 2-(4-Amino-3,5-dichloro-benzenesulfonylamino)-4-(2-cyano-pyrrol-l-yl)-butyric acid
Figure imgf000153_0001
A mixture of 1.8 g (5.7 mmol) of 1-044 in 10 mL of 4N HCl in 1,4-dioxane is stirred for Ih. The mixture is concentrated, and the residue dissolved in 10 mL of DMF. To this is added 16 mL (110 mmol) of Et3N, and 1.5 g (5.7 mmol) of 1-001. After stirring overnight, the mixture is diluted with EtOAc and washed three times with water, once with IN HCl, and once with brine. The solution is dried with MgSO4, filtered, and concentrated. Flash chromatography (2-5% MeOH in CH2Cl2) provides 1.7 g (69%) of 2-(4-amino-3,5-dichloro- benzenesulfonylamino)-4-(2-cyano-pyrrol-l-yl)-butyric acid methyl ester. To this material in 15 mL of dioxane is added 3.3 mL (9.9 mmol) of a 3M NaOH. After stirring for 3h, 2N HCl is added until the pH is 3. The mixture is extracted with EtOAc, and the extract is washed with brine, dried over Na2SO4, filtered, and concentrated to provide 1.4 g (85%) of 1-098 as a yellow oil.
1-099: 2-(2-Chloro-6-methyl-benzenesulfonylamino)-4-(2-cyano-pyrrol-l-yl)-butyric acid is prepared from 1-044 and 2-chloro-6-methylbenzenesulfonyl chloride in the same manner as 1-098.
I- 100: 2-(2,6-Dichlorobenzenesulfonylamino)-4-(2-cyano-pyrrol-l-yl)-butyric acid is prepared from 1-044 and 2,6-dichlorobenzenesulfonyl chloride in the same manner as 1-098. I- 101: 4-(2-Cyano-pyrrol-l-yl)-2-(lH-indole-6-sulfonylamino)-butyric acid is prepared from 1-044 and indol-6-ylsulfonyl chloride in the same manner as 1-098.
1-102: 4-(2-Cyano-pyrrol-l-yl)-2-(lH-indole-4-sulfonylamino)-butyric acid is prepared from 1-044 and indol-4-ylsulfonyl chloride in the same manner as 1-098.
1-103: 2-(3-Chloro-lH-indole-4-sulfonylamino)-4-(2-cyano-pyrrol-l-yl)-butyric acid
Figure imgf000154_0001
A solution of 0.20 g (0.52 mmol) of 4-(2-cyano-pyrrol-l-yl)-2-(lH-indole-4-sulfonylamino)- butyric acid methyl ester (from the synthesis of 1-102) and 0.070 g (0.52 mmol) of NCS in 1 mL of DMF is stirred overnight, and then diluted with MeCN and purified by preparative ΗPLC to provide 0.15 g (0.36 mmol; 69%) of 2-(3-chloro-lH-indole-4-sulfonylamino)-4-(2- cyano-pyrrol-l-yl)-butyric acid methyl ester. This material is stirred in 1.4 mL of TΗF with 1.4 mL of IM NaOH for 3h, and then 2N HCl is added until the pΗ is 3. The mixture is extracted with EtOAc, and the extract washed with brine, dried over Na2SO4, filtered, and concentrated to provide 0.12 g (85%) of 1-103 as a tan powder.
1-104: 2-(4-Amino-3,5-dichloro-benzenesulfonylamino)-4-(2-cyano-pyrrol-l-yl)-iV- methoxy-iV-methyl-butyr amide
Figure imgf000155_0001
To 300 mg (0.72 mmol) of 1-098, 280 mg (1.4 mmol) of EDC, 200 mg (1.4 mmol) of HOBt, and 18 mg (0.14 mmol) of DMAP is added 2 ml of DMF. The reaction mixture is stirred for 1 hour, and then 110 mg (1.1 mmol) of N-methylmethoxylamine hydrochloride and 0.25 mL (1.4 mmol) of /Pr2NEt are added. The mixture is stirred overnight, then diluted with EtOAc and washed with water, IN HCl, and brine. The organic layer is dried over MgSO4, filtered, and concentrated. Flash chromatography provides 210 mg of 1-104.
1-105: 2-(4-Amino-3,5-dichloro-benzenesulfonylamino)-Λ^-methoxy-Λ^-methyl-4-l,2,3- triazol-2-yl-butyramide
Figure imgf000155_0002
To 500 mg (1.3 mmol) of 1-097, 500 mg (2.5 mmol) of EDC, and 350 mg (2.5 mmol) of HOBt and 32 mg (0.25 mmol) of DMAP is added 15 ml of DMF. The reaction mixture is stirred for 20 minutes, and then 190 mg (1.9 mmol) of N-methylmethoxylamine hydrochloride and 0.35 mL (2.5 mmol) of Et3N are added. The mixture is stirred overnight, then diluted with EtOAc and washed with water, IN HCl, and brine. The organic layer is dried over MgSO4, filtered, and concentrated. Flash chromatography provides 330 mg of I- 105 as a yellow oil. Examples
General Method A (Sulfonamide formation): A mixture of 1 equivalent of amine or its salt, ≥l equivalent of sulfonyl chloride, and ≥l equivalent of an acid scavenger (≥2 equivalents in cases where amine salts are used) is stirred or shaken in the listed solvent for 2 to 24 h. Purification by preparative HPLC or flash chromatography provides Examples 1 - 210.
Example 1: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyljbenzenesulfonamide is prepared by reacting 1-089 with benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 414.2; Found: 415.2 (M+Η)+.
Example 2: Λ^-[l-(piperidin-l-ylcarbonyl)-3-(/H-pyrazol-l-yl)propyl]-/H-indole-4- sulfonamide is prepared by reacting 1-058 with 1-008 in CΗ2CI2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 415.2; Found: 416.1 (M+H)+.
Example 3: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl }thiophene-3-sulfonamide is prepared by reacting 1-089 with thiophene-3- sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 420.1; Found: 421.1 (M+Η)+.
Example 4: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-methylbenzenesulfonamide is prepared by reacting 1-089 with 2- methylbenzene sulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 428.2; Found: 430.1 (M+H)+.
Example 5: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3-methylbenzenesulfonamide is prepared by reacting 1-089 with 3- methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 428.2; Found: 429.2 (M+Η)+.
Example 6: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-methylbenzenesulfonamide is prepared by reacting 1-089 with A- toluenesulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 428.2; Found: 429.8 (M+Η)+.
Example 7: Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(/H-pyrazol-l-yl)propyl}-/H- indole-4-sulfonamide is prepared by reacting 1-085 with 1-008 in DMF with NMM as acid scavenger. ESI MS: CaIc: 429.2; Found: 430.5 (M+Η)+.
Example 8: Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(/H-pyrazol-l-yl)propyl}-/H- indole-6-sulfonamide is prepared by reacting 1-085 with 1-007 DMF with NMM as acid scavenger. ESI MS: CaIc: 429.2; Found: 430.5 (M+Η)+.
Example 9: Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2H-l,2,3-triazol-2-yl)propyl}- /H-indole-4-sulfonamide is prepared by reacting 1-065 with 1-008 in DMF with NMM as acid scavenger. ESI MS: CaIc: 430.2; Found: 431.5 (M+Η)+. Example 10: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3,5-dimethylisoxazole-4-sulfonamide is prepared by reacting 1-089 with 3,5-dimethylisoxazole-4-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 433.2; Found: 434.3 (M+Η)+.
Example 11: 2-cyano-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2- cyanobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 439.2; Found: 440.2 (M+Η)+.
Example 12: 3-cyano-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 3- cyanobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 439.2; Found: 440.2 (M+Η)+.
Example 13: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,4-dimethylbenzenesulfonamide is prepared by reacting 1-089 with 2,4- dimethyl benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 442.2; Found: 443.3 (M+Η)+.
Example 14: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,5-dimethylbenzenesulfonamide is prepared by reacting 1-089 with 2,5- dimethyl benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 442.2; Found: 443.3 (M+Η)+. Example 15: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3,5-dimethylbenzenesulfonamide is prepared by reacting 1-089 with 3,5- dimethylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 442.2; Found: 443.3 (M+Η)+.
Example 16: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-methoxybenzenesulfonamide is prepared by reacting 1-089 with 2- methoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 444.2; Found: 445.3 (M+Η)+.
Example 17: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3-methoxybenzenesulfonamide is prepared by reacting 1-089 with 3- methoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 444.2; Found: 445.2 (M+Η)+.
Example 18: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-methoxybenzenesulfonamide is prepared by reacting 1-089 with 4- methoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 444.2; Found: 445.2 (M+Η)+.
Example 19: Λ^-[l-{[4-(hydroxymethyl)piperidin-l-yl]carbonyl}-3-(/H-pyrazol-l-yl) propyl]-/H-indole-4-sulfonamide is prepared by reacting 1-059 with 1-008 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 445.2; Found: 446.3 (M+H)+. Example 20: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}- l,3,5-trimethyl-/H-pyrazole-4-sulfonamide is prepared by reacting 1-089 with l,3,5-trimethyl-iH-pyrazole-4-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 446.2; Found: 447.3 (M+Η)+.
Example 21: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-fluoro-2-methylbenzenesulfonamide is prepared by reacting 1-089 with 4-fluoro-2-methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 446.2; Found: 447.3 (M+Η)+.
Example 22 : 2-chloro-Λ^-{3-(2-cyano-/H- pyrrol- 1-yl)- 1- [(4-methylpiperidin- 1-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2- chlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 448.1; Found: 449.3 (M+Η)+.
Example 23: 3-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 3- chlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 448.1 ; Found: 449.2 (M+Η)+.
Example 24: 4-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 4- chlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 448.1 ; Found: 449.1 (M+Η)+. Example 25: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,5-dimethylthiophene-3-sulfonamide is prepared by reacting 1-089 with 2,5-dimethylthiophene-3-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 448.2; Found: 449.2 (M+Η)+.
Example 26: 2-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}pyridine-3-sulfonamide is prepared by reacting 1-089 with 2- chloropyridine-3-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 449.1 ; Found: 450.1 (M+Η)+.
Example 27: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,4-dimethyl-l,3-thiazole-5-sulfonamide is prepared by reacting 1-089 with 2,4-dimethyl-l,3-thiazole-5-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 449.2; Found: 450.2 (M+Η)+.
Example 28: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}- lH-indole-3-sulfonamide is prepared by reacting 1-089 with 1-018 in DMF with Et3N as acid scavenger, and with subsequent treatment with 1 equivalent of TBAF in TΗF. ESI MS: CaIc: 453.2; Found: 454.3 (M+Η)+.
Example 29: 2-cyano-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-5-methylbenzenesulfonamide is prepared by reacting 1-089 with 2-cyano-5-methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 453.2; Found: 454.2 (M+Η)+. Example 30: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-4-sulfonamide is prepared by reacting 1-089 with 1-008 in DMF with NMM as acid scavenger. ESI MS: CaIc: 453.2; Found: 454.5 (M+Η)+.
Example 31: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-6-sulfonamide is prepared by reacting 1-089 with 1-007 in DMF with NMM as acid scavenger. ESI MS: CaIc: 453.2; Found: 454.9 (M+Η)+.
Example 32: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}- l-benzofuran-7-sulfonamide is prepared by reacting 1-089 with benzofuran-7-sulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 454.2; Found: 455.3 (M+Η)+.
Example 33: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indazole-4-sulfonamide is prepared by reacting 1-089 with 1-020 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 454.2; Found: 455.2 (M+Η)+.
Example 34: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indazole-6-sulfonamide is prepared by reacting 1-089 with 1-025 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 454.2; Found: 455.4 (M+Η)+.
Example 35: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-5-sulfonamide is prepared by reacting 1-089 with 1-016 in DMF with NMM as acid scavenger. ESI MS: CaIc: 453.2; Found: 454.9 (M+Η)+. Example 36: Λ^-{3-(3-cyano-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-4-sulfonamide is prepared by reacting a 2:1 mixture of 1-086 and 1-091 with 1-008 in 4:1 CΗ2C12/DMF with Et3N as acid scavenger. Preparative HPLC provides pure Example 36. ESI MS: CaIc: 454.2; Found: 455.4 (M+H)+.
Example 37: Λ^-{3-(5-cyano-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-4-sulfonamide is prepared by reacting 1-091 with 1-008 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 454.2; Found: 455.5 (M+Η)+.
Example 38: 3-acetyl-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 3- acetylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 456.2; Found: 457.2 (M+Η)+.
Example 39: 4-acetyl-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 4- acetylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 456.2; Found: 457.2 (M+Η)+.
Example 40: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,4,6-trimethylbenzenesulfonamide is prepared by reacting 1-089 with 2,4,6-trimethyl benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 456.2; Found: 457.3 (M+Η)+. Example 41: 3-amino-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-2,4-dimethylbenzenesulfonamide is prepared by reacting 1-089 with 1-002 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 457.2; Found: 459.9 (M+Η)+.
Example 42: Λ^-[3-(2-cyano-/H-pyrrol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-2,5-dimethylbenzenesulfonamide is prepared by reacting 1-075 with 2,5-trichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 458.2; Found: 459.2 (M+Η)+.
Example 43: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-methoxy-4-methylbenzenesulfonamide is prepared by reacting 1-089 with 2-methoxy-4-methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 458.2; Found: 459.3 (M+Η)+.
Example 44: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-methoxy-5-methylbenzenesulfonamide is prepared by reacting 1-089 with 2-methoxy-5-methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 458.2; Found: 459.3 (M+Η)+.
Example 45: 2-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide is prepared by reacting 1-089 with 2-chloro-6-methylbenzenesulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 462.2; Found: 463.4 (M+Η)+. Example 46: 3-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-2-methylbenzenesulfonamide is prepared by reacting 1-089 with 3-chloro-2-methyl benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 462.2; Found: 463.2 (M+Η)+.
Example 47: Λ^-{3-(5-chloro-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-4-sulfonamide is prepared by reacting 1-082 with 1-008 in DMF with iPr2NEt as acid scavenger. ESI MS: CaIc: 463.1; Found: 464.4 (M+Η)+.
Example 48: Λ^-{3-(5-chloro-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-6-sulfonamide is prepared by reacting 1-082 with 1-007 in MeCN with NMM as acid scavenger. ESI MS: CaIc: 463.1; Found: 464.5 (M+Η)+.
Example 49: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}naphthalene-l-sulfonamide is prepared by reacting 1-089 with naphthalene- 1-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 464.2; Found: 465.3 (M+Η)+.
Example 50: N-benzyl-4-(2-cyano-/H-pyrrol-l-yl)-2-{[(2,5-dimethylphenyl) sulfonyl]amino}-Λ^-methylbutanamide is prepared by reacting 1-072 with 2,5- dimethylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 464.2; Found: 465.2 (M+Η)+.
Example 51: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}isoquinoline-5-sulfonamide is prepared by reacting 1-089 with isoquinoline- 5-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 465.2; Found: 466.3 (M+H)+.
Example 52: 2-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-4-fluorobenzenesulfonamide is prepared by reacting 1-089 with 2-chloro-4,5-difluorobenzensulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 466.1; Found: 467.2 (M+Η)+.
Example 53 : 5-chloro-Λ^-{3-(2-cyano-/H- pyrrol- 1-yl)- 1- [(4-methylpiperidin- 1-yl) carbonyl]propyl}-l,3-dimethyl-/H-pyrazole-4-sulfonamide is prepared by reacting 1-089 with 5-chloro-l,3-dimethyl-lH-pyrazole-4-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 466.2; Found: 467.2 (M+Η)+.
Example 54: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-l-methyl-/H-indole-4-sulfonamide is prepared by reacting 1-089 with 1- methylindole-4-sulfonyl chloride in DMF with iPr2NEt as acid scavenger. ESI MS: CaIc: 467.2; Found: 468.3 (M+Η)+.
Example 55: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-7-methyl-lH-indole-4-sulfonamide is prepared by reaction 1-089 with I- 009 in DMF with iPr2NEt as acid scavenger. ESI MS: CaIc: 467.2; Found: 468.2 (M+Η)+. Example 56: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-oxoindoline-5-sulfonamide is prepared by reacting 1-089 with 1-003 in DMF with NMM as acid scavenger. ESI MS: CaIc: 469.2; Found: 470.9 (M+Η)+.
Example 57: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}- l-benzothiophene-3-sulfonamide is prepared by reacting 1-089 with benzothiophene-3-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 470.1 ; Found: 471.1 (M+Η)+.
Example 58: Λ^-[3-(5-cyano-lH-pyrazol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide is prepared by reacting 1-092 with I- 008 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 470.2; Found: 471.3 (M+Η)+.
Example 59: Λ^-[3-(2-cyano-/H-pyrrol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-/H-indazole-4-sulfonamide is prepared by reacting 1-075 with I- 020 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 470.2; Found: 471.3 (M+H)+.
Example 60 : N-{3- [({3-(2-cyano-/H-pyrrol- 1-yl)- 1- [(4-methylpiperidin- l-yl)carbonyl] propyl}amino)sulfonyl]phenyl}acetamide is prepared by reacting 1-089 with 3- acetylamino-benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 471.2; Found: 472.2 (M+Η)+. Example 61: Λ^-{4-[({3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}amino)sulfonyl]phenyl}acetamide is prepared by reacting 1-089 with 4- acetylamino-benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 471.2; Found: 472.2 (M+Η)+.
Example 62: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,l,3-benzothiadiazole-4-sulfonamide is prepared by reacting 1-089 with 2,l,3-benzothiadiazole-4-sulfonyl chloride in DMF with NMM as acid scavenger. . ESI MS: CaIc: 472.1 ; Found: 473.2 (M+Η)+.
Example 63: 2-chloro-Λ^-{3-(5-chloro-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide is prepared by reacting 1-082 with 2-chloro-6-methylbenzenesulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 472.1 ; Found: 473.4 (M+Η)+.
Example 64: l-{3-[(/H-indol-4-ylsulfonyl)amino]-4-(4-methylpiperidin-l-yl)-4- oxobutyl}-/H-pyrazole-5-carboxamide is prepared by reacting 1-079 with 1-001 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 472.2; Found: 473.5 (M+Η)+.
Example 65: 4-(carbamoylamino)-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 4-(carbamoylamino) benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 472.2; Found: 473.3 (M+Η)+. Example 66: methyl 2-[({3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}amino)sulfonyl]benzoate is prepared by reacting 1-089 with 2- carbomethoxy benzenesulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 472.2; Found: 473.6 (M+Η)+.
Example 67: methyl 4-[({3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}amino)sulfonyl]benzoate is prepared by reacting 1-089 with methyl 4-chlorosulfonylbenzoate in DCE with NMM as acid scavenger. ESI MS: CaIc: 472.2; Found: 473.2 (M+Η)+.
Example 68: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-5-ethyl-2-methoxybenzenesulfonamide is prepared by reacting 1-089 with 5-ethyl-2-methoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 472.2; Found: 473.3 (M+Η)+.
Example 69: 2-chloro-4-cyano-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl] propyl }benzenesulfonamide is prepared by reacting 1-089 with 2- chloro-4-cyano benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 473.1 ; Found: 474.3 (M+Η)+.
Example 70: 4-amino-3,5-dichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(lH- pyrazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-085 with 1-001 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 473.1; Found: 474.0 (M+H)+. Example 71: 2-amino-4,6-dichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2H-l,2,3- triazol-2-yl)propyl}benzenesulfonamide is prepared by reacting 1-065 with 2- amino-4,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 474.1; Found: 475.2 (M+Η)+.
Example 72: 4-amino-3,5-dichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2H-l,2,3- triazol-2-yl)propyl}benzenesulfonamide is prepared by reacting 1-065 with 1-001 in CH2Cl2 with PS-NMM as acid scavenger. ESI MS: CaIc: 474.1; Found: 475.1 (M+H)+.
Example 73: Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H-imidazol-l-yl) propyl}-/H-indole-4-sulfonamide is prepared by reacting I-057a with 1-008 in DMF with NMM as acid scavenger. ESI MS: CaIc: 474.2; Found: 475.5 (M+Η)+.
Example 74: Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H-imidazol-l-yl) propyl}-/H-indole-6-sulfonamide is prepared by reacting I-057a with 1-008 in DMF with NMM as acid scavenger. ESI MS: CaIc: 474.2; Found: 475.5 (M+Η)+.
Example 75: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,5-dimethoxybenzenesulfonamide is prepared by reacting 1-089 with 2,5- dimethoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 474.2; Found: 475.3 (M+Η)+. Example 76: Λ^-benzyl-4-(2-cyano-/H-pyrrol-l-yl)-2-[(/H-indol-4-ylsulfonyl)amino]-Λ^- methylbutanamide is prepared by reacting 1-072 with 1-008 in 4:1 CΗ2C12/DMF with Et3N as acid scavenger. ESI MS: CaIc: 475.2; Found: 476.3 (M+H)+.
Example 77: 2-chloro-Λ^-[3-(2-cyano-/H-pyrrol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l- yl]carbonyl}propyl]-6-methylbenzenesulfonamide is prepared by reacting 1-075 with 2-chloro-6-methylbenzensulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 478.1; Found: 479.1 (M+Η)+.
Example 78 : 5-chloro-Λ^-{3-(2-cyano-/H- pyrrol- 1-yl)- 1- [(4-methylpiperidin- 1-yl) carbonyl]propyl}-2-methoxybenzenesulfonamide is prepared by reacting 1-089 with 5-chloro-2-methoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 478.1; Found: 479.2 (M+Η)+.
Example 79: 3-Amino-2,4-dimethyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with I- 002 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 478.2; Found: 479.3 (M+H)+.
Example 80: 4-(2-cyano-/H-pyrrol-l-yl)-2-{[(2,5-dimethylphenyl)sulfonyl]amino}-Λ^- methyl-iV-[(lR)-l-phenylethyl]butanamide is prepared by reacting 1-078 with 2,6- dichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 478.2; Found: 479.2 (M+Η)+. Example 81: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-methylnaphthalene-l-sulfonamide is prepared by reacting 1-089 with 4- methyl-naphthalene-1-sulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 478.2; Found: 479.7 (M+Η)+.
Example 82: Λ^-[3-(2-cyano-/H-pyrrol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l- yl]carbonyl}propyl]naphthalene-l-sulfonamide is prepared by reacting 1-075 with naphthalene- 1-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 480.2; Found: 481.2 (M+Η)+.
Example 83: Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2H-l,2,3-triazol-2-yl)propyl}- 2,4-dinitrobenzenesulfonamide is prepared by reacting I-065a with 2,4-dinitro benzenesulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 481.1 ; Found: 482.3 (M+Η)+.
Example 84: 2,3-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2,3- dichloro-benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 482.1 ; Found: 483.2 (M+Η)+.
Example 85: 2,5-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2,5- dichloro benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 482.1 ; Found: 483.1 (M+Η)+. Example 86: 2,6-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2,6- dichloro benzenesulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 482.1 ; Found: 483.3 (M+Η)+.
Example 87: 3,5-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 3,5- dichloro benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 482.1 ; Found: 483.1 (M+Η)+.
Example 88: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-(trifluoromethyl)benzenesulfonamide is prepared by reacting 1-089 with 2-(trifluoromethyl) benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 482.2; Found: 483.3 (M+Η)+.
Example 89: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3-(trifluoromethyl)benzenesulfonamide is prepared by reacting 1-089 with 3-(trifluoromethyl) benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 482.2; Found: 483.2 (M+Η)+.
Example 90: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[trans-octahydroisoquinolin-2(lH)-yl carbonyl]propyl}-2,5-dimethylbenzenesulfonamide is prepared by reacting 1-076 with 2,5-dimethylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 482.2; Found: 483.2 (M+H)+. Example 91: 2-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}-4,5-difluorobenzenesulfonamide is prepared by reacting 1-089 with 2-chloro-4,5-difluorobenzensulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 484.1 ; Found: 485.2 (M+Η)+.
Example 92: Λ^-benzyl-2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-/H- pyrrol-l-yO-jV-methylbutanamide is prepared by reacting 1-072 with 2-chloro-6- methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 484.1; Found: 485.1 (M+Η)+.
Example 93: 5-chloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}-3-methyl-l-benzothiophene-2-sulfonamide is prepared by reacting 1-089 with 5-chloro-3-methyl-l-benzothiophene-2-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 518.1 ; Found: 519.2 (M+Η)+.
Example 94 : N-{4- [({3-(2-cyano-/H-pyrrol- 1-yl)- 1- [(4-methylpiperidin- l-yl)carbonyl] propyl }amino)sulfonyl]-3-methylphenyl}acetamide is prepared by reacting 1-089 with 4-acetylamino-2-methyl-benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 485.2; Found: 486.3 (M+Η)+.
Example 95: methyl l-{3-[(/H-indol-4-ylsulfonyl)amino]-4-(4-methylpiperidin-l-yl)-4- oxobutyl}-/H-pyrrole-2-carboxylate is prepared by reacting 1-090 with 1-008 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 486.2; Found: 487.5 (M+H)+. Example 96: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-l-methyl-3-(trifluoromethyl)-/H-pyrazole-4-sulfonamide is prepared by reacting 1-089 with l-methyl-3-(trifluoromethyl)-iH-pyrazole-4-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 486.2; Found: 487.3 (M+Η)+.
Example 97: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-methoxy-2,3,6-trimethylbenzenesulfonamide is prepared by reacting I- 089 with 4-methoxy-2,3,5-trimethylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 486.2; Found: 487.3 (M+Η)+.
Example 98: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]- propyl}-5-methyl-2,l,3-benzothiadiazole-4-sulfonamide is prepared by reacting I- 089 with 5-methyl-2,l,3-benzothiadiazole-4-sulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 486.2; Found: 487.1 (M+Η)+.
Example 99: 2,5-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}thiophene-3-sulfonamide is prepared by reacting 1-089 with 2,5- dichlorothiophene-3-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 488.1 ; Found: 489.1 (M+Η)+.
Example 100: Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-methylnaphthalene-l-sulfonamide is prepared by reacting 1-066 with 4- methyl-naphthalene-1-sulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 488.2; Found: 489.2 (M+Η)+. Example 101: 2-bromo-N-[3-(2-cyano-/H-pyrrol-l-yl)-l-(piperidin-l-ylcarbonyl) propyl] -6-methylbenzenesulfonamide is prepared by reacting 1-073 with 1-029 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 492.1; Found: 493.2 (M+H)+.
Example 102: 2-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2- bromobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 492.1 ; Found: 493.2 (M+Η)+.
Example 103: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[trans-octahydroisoquinolin-2(lH)-yl carbonyl]propyl}-/H-indole-4-sulfonamide is prepared by reacting 1-089 with I- 076 in 4: 1 CΗ2C12/DMF with iPr2NEt as acid scavenger. ESI MS: CaIc: 493.2; Found: 494.4 (M+H)+.
Example 104: 6-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}imidazo[2,l-b][l,3]thiazole-5-sulfonamide is prepared by reacting 1-089 with 6-imidazo[2,l-&][l,3]thiazole-5-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 494.1 ; Found: 495.2 (M+Η)+.
Example 105: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-5-methyl-3-phenylisoxazole-4-sulfonamide is prepared by reacting 1-089 with 5-methyl-3-phenylizoxazole-4-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 495.2; Found: 496.3 (M+Η)+. Example 106: 2,4-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-5-methylbenzenesulfonamide is prepared by reacting 1-089 with 2,4-dichloro-5-methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 496.1; Found: 497.2 (M+Η)+.
Example 107: 2,4-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide is prepared by reacting 1-089 with 2,4-dichloro-6-methyl-benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 496.1; Found: 497.2 (M+Η)+.
Example 108: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,5,6-trimethyl-/H-benzimidazole-7-sulfonamide is prepared by reacting 1-089 with 1-006 in DMF with NMM as acid scavenger. ESI MS: CaIc: 496.2; Found: 497.8 (M+Η)+.
Example 109: 2-amino-4,6-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2-amino-4,6-dichlorobenzensulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 497.1; Found: 498.6 (M+Η)+.
Example 110: 4-amino-2,5-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 4-amino-2,5-dichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 497.1; Found: 498.2 (M+Η)+. Example 111: 4-amino-3,5-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 1-001 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 497.1 ; Found: 498.2 (M+H)+.
Example 112: 4-chloro-2,5-dimethyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with A- chloro-2,5-dimethylbenzenesulfonyl chloride in CH2Cl2 with Et3N as acid scavenger. ESI MS: CaIc: 497.2; Found: 497.9 (M+H)+.
Example 113: 4-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}thiophene-3-sulfonamide is prepared by reacting 1-089 with A- bromothiophene-3-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 498.0; Found: 499.1 (M+Η)+.
Example 114: 2,6-dichloro-N-[3-(2-cyano-/H-pyrrol-l-yl)-l-{[4-(hydroxymethyl) piperidin-l-yl]carbonyl}propyl]benzenesulfonamide is prepared by reacting 1-075 with 2,6-dichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 498.1; Found: 499.1 (M+Η)+.
Example 115: 4-amino-3,5-dichloro-Λ^-{3-(2-cyano-/H-imidazol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-083 with 1-001 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 498.1 ; Found: 499.2 (M+H)+. Example 116: 4-amino-3,5-dichloro-Λ^-{3-(5-cyano-/H-pyrazol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-091 with 1-001 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 498.1 ; Found: 499.2 (M+Η)+.
Example 117: 4-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyljpropyllnaphthalene-l-sulfonamide is prepared by reacting 1-089 with A- chloronaphthalene-1-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 498.2; Found: 499.3 (M+Η)+.
Example 118: Λ^-(4-chlorobenzyl)-4-(2-cyano-/H-pyrrol-l-yl)-2-{[(2,5-dimethyl phenyl)sulfonyl]amino}-Λ^-methylbutanamide is prepared by reacting 1-071 with 2,5-dimethylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 498.2; Found: 499.2 (M+Η)+.
Example 119: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-(trifluoromethoxy)benzenesulfonamide is prepared by reacting 1-089 with 2-(trifluoromethoxy) benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 498.2; Found: 499.3 (M+Η)+.
Example 120: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-fluoro-2-(trifluoromethyl)benzenesulfonamide is prepared by reacting I- 089 with 2-trifluoromethyl-4-fluorobenzene-sulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 500.2; Found: 501.7 (M+Η)+. Example 121 : 2-chloro-Λ^-{3-(2-cyano-/H- pyrrol- 1-yl)- 1- [trαns-octahydroisoquinolin- 2(lΗ)-ylcarbonyl]propyl}-6-methylbenzenesulfonamide is prepared by reacting I- 076 with 2-chloro-6-methylbenzensulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 502.2; Found: 503.2 (M+H)+.
Example 122: methyl 3-[({3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}amino)sulfonyl]-4-methoxybenzoate is prepared by reacting 1-089 with 3-chlorosulfonyl-4-methoxybenzoate in DCE with NMM as acid scavenger. ESI MS: CaIc: 502.2; Found: 503.2 (M+Η)+.
Example 123: N-benzyl-4-(2-cyano-/H-pyrrol-l-yl)-2-{[(2,6-dichlorophenyl)sulfonyl] amino}-Λ7-methylbutanamide is prepared by reacting 1-072 with 2,6-dichloro- benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 504.1; Found: 505.0 (M+Η)+.
Example 124: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[trαns-octahydroisoquinolin-2(lH)-yl carbonyl]propyl}naphthalene-l-sulfonamide is prepared by reacting 1-076 with naphthalene- 1-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 504.2; Found: 505.2 (M+H)+.
Example 125: Λ^-{2-chloro-4-[({3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}amino)sulfonyl]phenyl}acetamide is prepared by reacting 1-089 with 3-chloro-4-acetamidobenzene-sulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 505.2; Found: 506.6 (M+Η)+. Example 126: 2-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide is prepared by reacting 1-089 with 1-029 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 506.1 ; Found: 506.9 (M+Η)+.
Example 127: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3-(2-methylpyrimidin-4-yl)benzenesulfonamide is prepared by reacting I- 089 with 3-(2-methylpyrimidin-4-yl)benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 506.2; Found: (M+Η)+.
Example 128: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-phenoxybenzenesulfonamide is prepared by reacting 1-089 with A- phenoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 506.2; Found: 507.3 (M+Η)+.
Example 129: 4-amino-3,5-dichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-066 with 1-001 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 507.1 ; Found: 508.2 (M+H)+.
Example 130: Λ^-{3-(5-bromo-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-/H-indole-4-sulfonamide is prepared by reacting 1-080 with 1-008 in DMF with iPr2NEt as acid scavenger. ESI MS: CaIc: 507.1; Found: 508.4 (M+Η)+. Example 131: 2-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-4-fluorobenzenesulfonamide is prepared by reacting 1-089 with 2-bromo-4-fluorobenzensulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 510.1 ; Found: 511.2 (M+Η)+.
Example 132: 2-acetyl-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-l,2,3,4-tetrahydroisoquinoline-7-sulfonamide is prepared by reaction 1-089 with 2-acetyl-7-chlorosulphonyl-l,2,3,4-tetrahydroiso-quinoline (Pendelton, R. G., et al. J. Pharmacol. Exp. Ther., 1979, 2OS, 24) in DCE with NMM as acid scavenger. ESI MS: CaIc: 511.2; Found: 512.3 (M+Η)+.
Example 133: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-4-(2-methyl-l,3-thiazol-4-yl)benzenesulfonamide is prepared by reacting I- 089 with 4-(2-methyl-l,3-thiazol-4-yl)benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 511.2; Found: 512.2 (M+Η)+.
Example 134: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-methoxy-5-(trifluoromethyl)benzenesulfonamide is prepared by reacting 1-089 with 2-methoxy-5-(trifluoromethyl) benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 512.2; Found: 513.2 (M+Η)+.
Example 135: 2-bromo-Λ^-{ 1- [(4-methylpiperidin- l-yl)carbonyl] -3-(2-nitro-/H-imidazol- l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with 2- (trifluoromethyl) benzenesulfonyl chloride in CΗ2CI2 with Et3N as acid scavenger. ESI MS: CaIc: 513.1 ; Found: 514.4 (M+H)+. Example 136 : 2-amino-4,6-dichloro-Λ^-{ 1- [αs-octahydroisoquinolin-2(lH)-ylcarbonyl] - 3-(2H-l,2,3-triazol-2-yl)propyl}benzenesulfonamide is prepared by reacting 1-064 with 2-amino-4,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 514.1; Found: 515.1 (M+Η)+.
Example 137: 2,4,6-trichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide is prepared by reacting 1-089 with 2,4,6- trichloro benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 516.1; Found: 517.2 (M+Η)+.
Example 138: 2-chloro-Λ^-{3-(5-bromo-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide is prepared by reacting 1-080 with 2-chloro-6-methylbenzenesulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 516.1 ; Found: 517.2 (M+Η)+.
Example 139: 2,4-dichloro-6-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with 2,4-dichloro-6-methyl-benzenesulfonyl chloride in CΗ2CI2 with Et3N as acid scavenger. ESI MS: CaIc: 517.1 ; Found: 518.4 (M+H)+.
Example 140: 4-(2-cyano-/H-pyrrol-l-yl)-2-{[(2,6-dichlorophenyl)sulfonyl]amino}-iV- methyl-Λ^-[(lR)-l-phenylethyl]butanamide is prepared by reacting 1-078 with 2,6- dichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 518.1; Found: 519.1 (M+Η)+. Example 141 : 4-amino-3,5-dichloro-Λ^-{ 1- [(4-methylpiperidLV- l-yl)carbonyl] -3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with I- 001 in CH2Cl2 with Et3N as acid scavenger. ESI MS: CaIc: 518.1 ; Found: 519.0 (M+H)+.
Example 142: Λ^-(4-chlorobenzyl)-2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2- cyano-/H-pyrrol-l-yl)-Λ^-methylbutanamide is prepared by reacting 1-071 with 2- chloro-6-methylbenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 518.1 ; Found: 519.1 (M+Η)+.
Example 143: 2,6-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[trans-octahydro isoquinolin-2(/H)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-076 with 2,6-dichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 522.1 ; Found: 523.1 (M+Η)+.
Example 144: 5-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-2-methoxybenzenesulfonamide is prepared by reacting 1-089 with 5-bromo-2-methoxy benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 522.1; Found: 523.1 (M+Η)+.
Example 145: Λ^-[3-(2-chloro-/H-imidazol-l-yl)-l-(3,4-dihydroisoquinolin-2(lH)-yl carbonyl)propyl]-4-methylnaphthalene-l-sulfonamide is prepared by reacting I- 069 with 4-methyl-naphthalene-l-sulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 522.2; Found: 523.3 (M+H)+. Example 146 : 4-amino-3,5-dichloro-Λ^-{ 1- [(4-methylpiperidin- l-yl)carbonyl] -3-(1H- pyrrolo[2,3-Z>]pyridin-l-yl)propyl}benzenesulfonamide is prepared by reacting I- 088 with 1-001 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 523.1 ; Found: 524.0 (M+Η)+.
Example 147: N-[3-(5-bromo-/H-pyrazol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-/H-indole-4-sulfonamide is prepared by reacting 1-081 with I- 008 in DMF with iPr2NEt as acid scavenger. ESI MS: CaIc: 523.1; Found: 378.1 (M- C4H3BrN)+.
Example 148: 4-({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]- propyl}sulfamoyl)-ΛyV-dimethyl-lH-indole-2-carboxamide is prepared by reaction 1-089 with 1-010 in DMF with /Pr2NEt as acid scavenger. ESI MS: CaIc: 524.2; Found: 525.7 (M+Η)+.
Example 149: 2-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-phenylpiperazin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide is prepared by reacting 1-074 with 2-methyl-6-chlorobenzenesulfonyl chloride in DMF with NMM as acid scavenger. ESI MS: CaIc: 525.2; Found: 526.4 (M+Η)+.
Example 150: 2,4,6-trichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl] propyl }benzenesulfonamide is prepared by reacting 1-066 with 2,4,6- trichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 526.0; Found: 527.1 (M+Η)+. Example 151: 2-bromo-6-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-
/H-imidazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with I- 029 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 527.1 ; Found: 528.2 (M+H)+.
Example 152: 2-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-4,6-difluorobenzenesulfonamide is prepared by reacting 1-089 with 2-bromo-4,6-difluorobenzensulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 528.1 ; Found: 529.2(M+Η)+.
Example 153: Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[cis-octahydroisoquinolin-2(lH)-yl carbonyl]propyl}-4-methylnaphthalene-l-sulfonamide is prepared by reacting I-
067 with 4-methyl-naphthalene-l-sulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 528.2; Found: 529.3 (M+H)+.
Example 154: Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[trαns-octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}-4-methylnaphthalene-l-sulfonamide is prepared by reacting I-
068 with 4-methyl-naphthalene-l-sulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 528.2; Found: 529.3 (M+H)+.
Example 155: 2,4,6-trichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(hydroxymethyl) piperidin-l-yl]carbonyl}propyl]benzenesulfonamide is prepared by reacting 1-075 with 2,4,6-trichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 532.1; Found: 533.0 (M+Η)+. Example 156: 2,6-dichloro-Λ^-[3-(2-chloro-/H-imidazol-l-yl)-l-(3,4-dihydro isoquinolin- 2(lΗ)-ylcarbonyl)propyl]benzenesulfonamide is prepared by reacting 1-069 with 2,6-dichloro benznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 526.0; Found: 527.1 (M+H)+.
Example 157: 2,6-dichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[cis-octahydro isoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-067 with 2,6-dichloro benznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 532.1 ; Found: 533.1 (M+H)+.
Example 158: 2,6-dichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[trans-octahydro isoquinolin-2(/H)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-068 with 2,6-dichloro benznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 532.1 ; Found: 533.1 (M+Η)+.
Example 159: 2-{[(4-amino-3,5-dichlorophenyl)sulfonyl]amino}-4-(2-cyano-/H-pyrrol- l-yl)-N-methyl-N-[(lR)-l-phenylethyl]butanamide is prepared by reacting 1-078 TFA with 1-001 in DMF with NMM as acid scavenger. ESI MS: CaIc: 533.1 ; Found:
534.3 (M+Η)+.
Example 160: Λ^-[l-(3,4-dihydroisoquinolin-2(lH)-ylcarbonyl)-3-(2-nitro-/H-imidazol-l- yl)propyl]-4-methylnaphthalene-l-sulfonamide is prepared by reacting 1-060 with 4-methyl-naphthalene-l-sulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 533.2; Found: 534.3 (M+Η)+. Example 161: 5-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-2,3-dihydro-l-benzofuran-7-sulfonamide is prepared by reacting 1-089 with 5-bromo-2,3-dihydro-l-benzofuran-7-sulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 534.1 ; Found: 535.2 (M+Η)+.
Example 162: 2,6-dichloro-Λ^-[l-(3,4-dihydroisoquinolin-2(lH)-ylcarbonyl)-3-(2-nitro- /H-imidazol-l-yl)propyl]benzenesulfonamide is prepared by reacting 1-060 with 2,6-dichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 537.1 ; Found: 538.1 (M+Η)+.
Example 163: Λ^-(4-chlorobenzyl)-4-(2-cyano-/H-pyrrol-l-yl)-2-{[(2,6-dichlorophenyl) sulfonyl]amino}-Λ^-methylbutanamide is prepared by reacting 1-071 with 2,6- dichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 538.0; Found: 539.1 (M+Η)+.
Example 164: Λ^-benzyl-4-(2-cyano-/H-pyrrol-l-yl)-Λ^-methyl-2-{[(2,4,6-trichloro phenyl) sulfonyl] amino }butanamide is prepared by reacting 1-072 with 2,4,6- trichlorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 538.0; Found: 538.9 (M+Η)+.
Example 165: 4-methyl-Λ^-{3-(2-nitro-/H-imidazol-l-yl)-l-[cis-octahydroisoquinolin-
2(lΗ)-ylcarbonyl]propyl}naphthalene-l-sulfonamide is prepared by reacting 1-062 with 4-methyl-naphthalene-l -sulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 539.2; Found: 540.3 (M+H)+. Example 166: 4-methyl-Λ^-{3-(2-nitro-/H-imidazol-l-yl)-l-[trans-octahydro isoquinolin- 2(lΗ)-ylcarbonyl]propyl}naphthalene-l-sulfonamide is prepared by reacting 1-061 with 4-methyl-naphthalene-l-sulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 539.2; Found: 540.3 (M+H)+.
Example 167: 2-amino-4,6-dichloro-N-[3-(2-chloro-/H-imidazol-l-yl)-l-(3,4-dihydro isoquinolin-2(lΗ)-ylcarbonyl)propyl]benzenesulfonamide is prepared by reacting 1-069 with 2-amino-4,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 541.1 ; Found: 542.1 (M+H)+.
Example 168: 4-amino-3,5-dichloro-Λ^-[3-(2-chloro-/H-imidazol-l-yl)-l-(3,4-dihydro isoquinolin-2(lΗ)-ylcarbonyl)propyl]benzenesulfonamide is prepared by reacting 1-069 with 4-amino-2,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 541.1 ; Found: 542.1 (M+H)+.
Example 169: 2,6-dichloro-Λ^-{3-(2-nitro-/H-imidazol-l-yl)-l-[cis-octahydro isoquinolin-2(/H)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-062 with 2,6-dichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 543.1 ; Found: 544.2 (M+Η)+.
Example 170: 2,6-dichloro-Λ^-{3-(2-nitro-/H-imidazol-l-yl)-l-[trαns-octahydro isoquinolin-2(/H)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-061 with 2,6-dichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 543.1 ; Found: 544.2 (M+Η)+. Example 171: 2-bromo-N-[3-(2-cyano-/H-pyrrol-l-yl)-l-{[4-(hydroxymethyl) piperidin- l-yl]carbonyl}propyl]-4,6-difluorobenzenesulfonamide is prepared by reacting I- 075 with 2-bromo-4,6-difluorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 544.1; Found: 545.1 (M+Η)+.
Example 172: 2-amino-4,6-dichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[cis-octahydro isoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-067 with 2-amino-4,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 547.1 ; Found: 548.1 (M+H)+.
Example 173: 2-amino-4,6-dichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[trans-octa hydroisoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-068 with 2-amino-4,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 547.1 ; Found: 548.1 (M+H)+.
Example 174: 4-amino-3,5-dichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[cis-octahydro isoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-067 with 4-amino-2,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 547.1 ; Found: 548.1 (M+H)+.
Example 175: 4-amino-3,5-dichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[trans-octa hydroisoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-068 with 4-amino-2,6-dichlorobenznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 547.1 ; Found: 548.1 (M+H)+. Example 176: N-benzyl-2-{[(2-bromo-4,6-difluorophenyl)sulfonyl]amino}-4-(2-cyano- /H-pyrrol-l-yl)-Λ^-methylbutanamide is prepared by reacting 1-072 with 2-bromo- 4,6-difluorobenzenesulfonyl chloride in DEC with NMM as acid scavenger. ESI MS: CaIc: 550.1; Found: 551.0 (M+Η)+.
Example 177: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2,5-bis(trifluoromethyl)benzenesulfonamide is prepared by reacting 1-089 with 2,5-bis(trifluoromethyl) benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 550.2; Found: 551.2 (M+Η)+.
Example 178: 4-amino-Λ^-{3-(2-bromo-/H-imidazol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-3,5-dichlorobenzenesulfonamide is prepared by reacting 1-084 with 1-001 in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 551.0; Found:
552.1 (M+H)+.
Example 179: 2-amino-4,6-dichloro-Λ^-[l-(3,4-dihydroisoquinolin-2(lH)-ylcarbonyl)-3- (2-nitro-/H-imidazol-l-yl)propyl]benzenesulfonamide is prepared by reacting I- 060 with 2-amino-4,6-dichlorobenzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 552.1; Found: 553.1 (M+Η)+.
Example 180: 2-{[(4-amino-3,5-dichlorophenyl)sulfonyl]amino}-Λ^-(4-chlorobenzyl)-4- (2-cyano-/H-pyrrol-l-yl)-Λ^-methylbutanamide is prepared by reacting 1-071 TFA with 1-001 in DMF with NMM as acid scavenger. ESI MS: CaIc: 553.1; Found:
554.2 (M+Η)+. Example 181: 7-[3-(2-cyano-pyrrol-l-yl)-l-(4-methyl-piperidine-l-carbonyl)- propylsulfamoyl] -indole- 1-carboxylic acid tert-butyl ester is prepared by reaction 1-089 with 1-017 in THF with /Pr2NEt as acid scavenger. ESI MS: CaIc: 553.2; Found: 554.3 (M+H)+.
Example 182: 2,4,6-trichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[trans-octahydro isoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-076 with 2,4,6-trichloro benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 556.1 ; Found: 557.0 (M+H)+.
Example 183: 2-amino-4,6-dichloro-Λ^-{3-(2-nitro-/H-imidazol-l-yl)-l-[cis-octahydro isoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-062 with 2-amino-4,6-dichlorobenzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 558.1 ; Found: 559.2 (M+H)+.
Example 184: 2-amino-4,6-dichloro-Λ^-{3-(2-nitro-/H-imidazol-l-yl)-l-[trαns-octa hydroisoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-061 with 2-amino-4,6-dichlorobenzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 558.1; Found: 559.2 (M+H)+.
Example 185: 2-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-5-(trifluoromethyl)benzenesulfonamide is prepared by reacting 1-089 with 2-bromo-5-(trifluoromethyl)-benzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 560.1 ; Found: 561.1 (M+Η)+. Example 186: 2-amino-4,6-dichloro-Λ^-[3-(2-chloro-/H-imidazol-l-yl)-l-{[4-
(trifluoromethyl)piperidin-l-yl]carbonyl}propyl]benzenesulfonamide is prepared by reacting 1-070 with 2-amino-4,6-dichlorobenzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 561.0; Found: 562.0 (M+Η)+.
Example 187: 2-{[(2-bromo-4,6-difluorophenyl)sulfonyl]amino}-4-(2-cyano-/H-pyrrol- l-yl)-N-methyl-N-[(lR)-l-phenylethyl]butanamide is prepared by reacting 1-078 with 2-bromo-4,6-difluorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 564.1; Found: 565.1 (M+Η)+.
Example 188: 4-bromo-2,5-dichloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methyl piperidin-l-yl)carbonyl]propyl}thiophene-3-sulfonamide is prepared by reacting I- 089 with 4-bromo-2,5-dichloro-thiophene-3-sulfonyl chloride in DMF with Et3N as acid scavenger. ESI MS: CaIc: 566.0; Found: 567.0 (M+Η)+.
Example 189: 2,4,6-trichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[(cis)-octahydro isoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-066 with 2,4,6-trichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 566.1 ; Found: 567.1 (M+H)+.
Example 190: 2,4,6-trichloro-Λ^-{3-(2-chloro-/H-imidazol-l-yl)-l-[(trans)-octahydro isoquinolin-2(lΗ)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-068 with 2,4,6-trichloro benznesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 566.1; Found: 567.1 (M+H)+. Example 191: tert-bntyl 3-[({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}amino)sulfonyl]-2-methyl-lH-indole-l-carboxylate is prepared by reacting 1-089 with 1-019 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 567.3; Found: 568.3 (M+Η)+.
Example 192: 2-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(trans)-octahydroisoquinolin- 2(lΗ)-ylcarbonyl]propyl}-4,6-difluorobenzenesulfonamide is prepared by reacting 1-076 with 2-bromo-4,6-difluorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 568.1; Found: 569.1 (M+H)+.
Example 193: 2,4,6-trichloro-Λ^-[l-(3,4-dihydroisoquinolin-2(lH)-ylcarbonyl)-3-(2-nitro- /H-imidazol-l-yl)propyl]benzenesulfonamide is prepared by reacting 1-060 with 2,4,6-trichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 571.0; Found: 572.1 (M+Η)+.
Example 194: 4-[3-(2-cyano-pyrrol-l-yl)-l-(4-methyl-piperidine-l-carbonyl)- propylsulfamoyl]-5-fluoro-indole-l-carboxylic acid tert-butyl ester is prepared by reaction 1-089 with 1-021 in THF with /Pr2NEt as acid scavenger. ESI MS: CaIc: 571.1; Found: 572.3 (M+H)+.
Example 195: 6-[3-(2-cyano-pyrrol-l-yl)-l-(4-methyl-piperidine-l-carbonyl)- propylsulfamoyl]-5-fluoro-indole-l-carboxylic acid tert-butyl ester is prepared by reacting 1-089 with 1-022 in THF with /Pr2NEt as acid scavenger. ESI MS: CaIc: 571.1; Found: 572.3 (M+H)+. Example 196: 2-amino-4,6-dichloro-Λ^-[3-(2-nitro-/H-imidazol-l-yl)-l-{[4-
(trifluoromethyl)piperidin-l-yl]carbonyl}propyl]benzenesulfonamide is prepared by reacting 1-063 with 2-amino-4,6-dichlorobenzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 572.1 ; Found: 573.1 (M+Η)+.
Example 197: 2,4,6-trichloro-Λ^-{3-(2-nitro-lH-imidazol-l-yl)-l-[(cis)-octahydro isoquinolin-2(lH)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-062 with 2,4,6-trichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 577.1 ; Found: 578.1 (M+Η)+.
Example 198: 2,4,6-trichloro-Λ^-{3-(2-nitro-lH-imidazol-l-yl)-l-[(trans)-octahydro isoquinolin-2(lH)-ylcarbonyl]propyl}benzenesulfonamide is prepared by reacting 1-061 with 2,4,6-trichloro benzenesulfonyl chloride in DCE with Et3N as acid scavenger. ESI MS: CaIc: 577.1 ; Found: 578.1 (M+Η)+.
Example 199 : 4-bromo-2,6-dichloro-Λ^-{ 1- [(4-methylpiperidin- l-yl)carbonyl] -3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with 4- bromo-2,6-dichlorobenzenesulfonyl chloride in CΗ2CI2 with Et3N as acid scavenger. ESI MS: CaIc: 581.0; Found: 582.2 (M+H)+.
Example 200: 2-{[(2-bromo-4,6-difluorophenyl)sulfonyl]amino}-Λ^-(4-chlorobenzyl)-4- (2-cyano-/H-pyrrol-l-yl)-Λ^-methylbutanamide is prepared by reacting 1-071 with 2-bromo-4,6-difluorobenzenesulfonyl chloride in DCE with NMM as acid scavenger. ESI MS: CaIc: 584.0; Found: 585.0 (M+Η)+. Example 201: 5-chloro-4-[3-(2-cyano-pyrrol-l-yl)-l-(4-methyl-piperidine-l-carbonyl)- propylsulfamoyl] -indole- 1-carboxylic acid tert-butyl ester is prepared by reacting 1-089 with 1-023 in THF with /Pr2NEt as acid scavenger. ESI MS: CaIc: 587.2; Found: 588.8 (M+H)+.
Example 202: 5-chloro-6-[3-(2-cyano-pyrrol-l-yl)-l-(4-methyl-piperidine-l-carbonyl)- propylsulfamoyl] -indole- 1-carboxylic acid tert-butyl ester is prepared by reacting 1-089 with 1-024 in THF with /Pr2NEt as acid scavenger. ESI MS: CaIc: 587.2; Found: 588.3 (M+H)+.
Example 203: 4-amino-3,5-dibromo-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide is prepared by reacting 1-057 with A- amino-3,5-dibromo benzenesulfonyl chloride in CH2Cl2 with iPr2NEt as acid scavenger. ESI MS: CaIc: 606.0; Found: 607.2 (M+H)+.
Example 204: 5-chloro-4-[3-(2-cyano-pyrrol-l-yl)-l-(5,6-dihydro-8H-l,2,4-triazolo [4,3- αJpyrazine-T-carbonyO-propylsulfamoylΗndole-l-carboxylic acid tert-butyl ester is prepared by reaction 1-077 with 1-023 in TΗF with /Pr2NEt as acid scavenger. ESI MS: CaIc: 612.2; Found: 613.3 (M+Η)+.
Example 205: 5-chloro-6-[3-(2-cyano-pyrrol-l-yl)-l-(5,6-dihydro-8H-l,2,4-triazolo [4,3- α]pyrazine-7-carbonyl)-propylsulfamoyl]-indole-l-carboxylic acid tert-butyl ester is prepared by reacting 1-077 with 1-024 in TΗF with /Pr2NEt as acid scavenger. Example 206: 4-[3-(2-cyano-pyrrol-l-yl)-l-(4-methyl-piperidine-l-carbonyl)- propylsulfamoyl]-l-(2-trimethylsilanyl-ethoxymethyl)-lH-indole-7-carboxylic acid is prepared by reaction 1-089 with 1-028 in DMF with Et3N as acid scavenger. ESI MS: CaIc: 627.3; Found: 628.2 (M+Η)+.
Example 207: 3-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}-/H-indazole-5-sulfonamide and Example 208: 3-chloro-N-{3- (2-cyano-lΗ-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-lΗ- indazole-7-sulfonamide are prepared by reacting 1-089 with 1 : 1 mixture of 1-004 and 1-005 in DMF with NMM as acid scavenger. Example 207: ESI MS: CaIc: 488.1; Found: 489.2. Example 208: ESI MS. CaIc. 488.1; Found 489.6 (M+H)+.
Example 209: 4-amino-3,5-dichloro-Λ^-{3-(3-chloro-/H-pyrazol-l-yl)-l-[(4- methylpiperidin-l-yl)carbonyl]propyl}benzenesulfonamide and Example 210: 4- amino-3,5-dichloro-N-{3-(5-chloro-lΗ-pyrazol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl] propyl }benzenesulfonamide are prepared by reacting 1-087 and 1-082 with 1-001 in CH2Cl2 with iPr2NEt as acid scavenger. Example 209: ESI MS: CaIc: 507.1; Found: 508.2. Example 210: ESI MS. CaIc: 507.1; Found: 508.2 (M+H)+.
Example 211: 2-amino-4,6-dichloro-Λ^-{3-(2-chloro-lH-imidazol-l-yl)-l-[(4- methylpiperidin-l-yl)carbonyl]propyl}benzenesulfonamide and Example 212: 2-amino- 4,6-dichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-lH-imidazol-l- yl)propyl}benzenesulfonamide
Figure imgf000198_0001
A mixture of 120 mg (0.31 mmol) of [l-(4-methyl-piperidine-l-carbonyl)-3-(2-nitro- imidazol-l-yl)-propyl]-carbamic acid tert-butyl ester (prepared in the synthesis of 1-057) in 5 mL of 4 M HCl in 1,4-dioxane is stirred for Ih, and then concentrated. This residue is suspended in 5 mL of CH2Cl2, and 88 mg (0.34 mmol) of 1-001 and 0.16 mL (0.92 mmol) of /Pr2NEt are added. After 16 h, the mixture is washed with 1 M KHSO4, dried with MgSO4, filtered, and evaporated. The mixture is purified by preparative HPLC to provide 13 mg (8.3%) of Example 211 and 110 mg (67 %) of Example 212. Example 211: ESI MS: CaIc: 507.1; Found: 508.0 (M+H)+. Example 212: ESI MS. CaIc: 518.1; Found: 519.1 (M+H)+.
Example 213: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}- lH-pyrrolo[2,3-b]pyridine-4-sulfonamide and Example 214: 3-bromo-Λ^-{3-(2- cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-lH-pyrrolo[2,3- b]pyridine-4-sulfonamide
Figure imgf000198_0002
To a stirring mixture of 50 mg (0.16 mmol) of 1-089 in 2.0 mL of DMF is added 0.080 mL (0.57 mmol) of Et3N and 42 mg of a mixture of I-026and 1-027. The mixture is stirred overnight and purified directly by preparative HPLC to provide 2 mg (3%) of Example 213 and 3 mg (5%) of Example 214. Example 213: ESI MS: CaIc: 454.2; Found: 455.6 (M+H)+. Example 214: ESI MS. CaIc: 532.1; Found: 533.5 (M+H)+.
Example 215: 2,6-dichloro-N-{3-(2-chloro-lH-imidazol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}benzenesulfonamide and Example 216: 2,6-dichloro-iV-{l-[(4- methylpiperidin-l-yl)carbonyl]-3-(2-nitro-lH-imidazol-l-yl)propyl}benzenesulfonamide
Figure imgf000199_0001
A mixture of 120 mg (0.31 mmol) of [l-(4-methyl-piperidine-l-carbonyl)-3-(2-nitro- imidazol-l-yl)-propyl]-carbamic acid tert -butyl ester (from the synthesis of 1-057) in 5 mL of 4 M HCl in 1,4-dioxane is stirred for Ih and then is concentrated. This residue is suspended in 5 mL of CΗ2CI2, and 83 mg (0.34 mmol) of 2,6-dichlorobenzenesulfonyl chloride and 0.16 mL (0.93 mmol) of /Pr2NEt are added. After 16 h, the mixture is washed with 1 M KHSO4, and dried with MgSO4, filtered, and evaporated. The mixture is purified by preparative HPLC to provide 13 mg (8.5%) of Example 215 and 130 mg (81 %) of Example 216. Example 215: ESI MS: CaIc: 492.1; Found: 493.0 (M+H)+. Example 216: ESI MS. CaIc: 503.1 ; Found: 504.4 (M+H)+. General Method B (Sulfonamide Formation): To 20 mg (0.068 mmol) of 1-057 in 1 mL of
DCE is added 0.019 mL of Et3N (0.14 mmol) and a solution of 0.1 mmol of a sulfonyl chloride in 0.5 mL of DCE. After shaking for 45 min, 0.1 Ig (7 equiv) of PS-trisamine and 0.17 g (7 equiv) of MP-carbonate are added, and the mixture is shaken for 24 h. The mixture is filtered, and the filtrate concentrated to provide product. Flash chromatography (1-5% MeOH/ CH2CI2) is used when necessary. Examples 217 - 234 are prepared from the indicated sulfonyl chlorides via this method.
Example 217: 2,5-dimethoxy-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}benzenesulfonamide from 2,5-dimethoxybenzenesulfonyl chloride. ESI MS. CaIc: 495.2; Found: 496.3 (M+Η)+.
Example 218: 2-methoxy-4-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol- l-yl)propyl}benzenesulfonamide from 2-methoxy-4-methylbenzene- sulphonyl chloride. ESI MS. CaIc: 478.2; Found: 479.5 (M+Η)+.
Example 219: Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H-imidazol-l-yl) propyl}naphthalene-l-sulfonamide from 1-napthalenesulfonyl chloride. ESI MS. CaIc: 485.2; Found: 485.6 (M+Η)+.
Example 220: 2,3,4-trichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}benzenesulfonamide from 2,3,4-trichlorobenzenesulfonyl chloride. ESI MS. CaIc: 537.0; Found: 538.2 (M+Η)+. Example 221: 2,3-dichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}benzenesulfonamide from 2,3-dichlorobenzenesulfonyl chloride. ESI MS. CaIc: 503.1; Found: 504.4 (M+Η)+.
Example 222: 2,4,6-trichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}benzenesulfonamide from 2,4,6-trichlorobenzenesulfonyl chloride. ESI MS. CaIc: 537.0; Found: 538.2 (M+Η)+.
Example 223: 2,4,6-trimethyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}benzenesulfonamide from 2-mesitylenesulfonyl chloride. ESI MS. CaIc: 477.2; Found: 477.6 (M+Η)+.
Example 224: 2,4-dichloro-5-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide from 2,4-dichloro-5-methylbenzene- 1-sulfonyl chloride. ESI MS. CaIc: 517.1; Found: 518.4 (M+Η)+.
Example 225: 2-trifluoromethyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}benzenesulfonamide from 2-(trifluoromethyl)- benzenesulfonyl chloride.
Example 226: 2-chloro-6-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol- l-yl)propyl}benzenesulfonamide from 2-chloro-6-methylbenzenesulfonyl chloride. ESI MS. CaIc: 483.1; Found: 483.9 (M+Η)+. Example 227: 2-methoxy-5-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-
/H-imidazol-l-yl)propyl}benzenesulfonamide from 6-methoxy-m-toluenesulfonyl chloride. ESI MS. CaIc: 479.2; Found: 479.5 (M+Η)+.
Example 228: 3-bromo-5-chloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}thiophene-2-sulfonamide from 3-bromo-5-chlorothiophene-2- sulfonyl chloride. ESI MS. CaIc: 553.0; Found: 554.2 (M+Η)+.
Example 229: 3-chloro-2-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol- l-yl)propyl}benzenesulfonamide from 3 -chloro-2-methylbenzenesulfonyl chloride. ESI MS. CaIc: 483.1; Found: 483.9 (M+Η)+.
Example 230: 4-bromo-2,5-dichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol-l-yl)propyl}thiophene-3-sulfonamide from 4-bromo-2,5- dichlorothiophene-3-sulfonyl chloride. ESI MS. CaIc: 587.0; Found: 588.1 (M+Η)+.
Example 231: 4-methoxy-2,3,6-trimethyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2- nitro-/H-imidazol-l-yl)propyl}benzenesulfonamide from 4-methoxy-2,3,6- trimethyl-benzenesulphonyl chloride. ESI MS. CaIc: 507.2; Found: 508.4 (M+Η)+.
Example 232: 4-methyl-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro-/H- imidazol-l-yl)propyl}naphthalene-l-sulfonamide from 4-methyl-l- naphthalenesulfonyl chloride. ESI MS. CaIc: 499.2; Found: 500.3 (M+Η)+. Example 234: 5-bromo-2-methoxy-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(2-nitro- /H-imidazol-l-yl)propyl}benzenesulfonamide from 5-bromo-2- methoxybenzenesulfonyl chloride. ESI MS. CaIc: 543.1; Found: 544.4 (M+Η)+.
Example 235: 4-amino-3,5-dichloro-Λ^-{l-[(4-methylpiperidin-l-yl)carbonyl]-3-(/H- pyrrol-l-yl)propyl}benzenesulfonamide
Figure imgf000203_0001
A mixture of Ig (3.4 mmol) of 1-042 and 330 mg (5.0 mmol) of NaN3 in 4 mL of DMF and 0.4 mL of water is stirred for 3 days. The mixture is diluted with EtOAc and washed twice with water and once with brine, and then dried with Na2SO4, filtered, and concentrated to provide 860 mg (99%) of 4-azido-2-ferz-butoxycarbonylamino-butyric acid methyl ester. To this compound (500 mg, 1.9 mmol) in 2 mL of 50% 1,4-dioxane in water is added 160 mg (3.9 mmol) of NaOH. After stirring for 30 min, the mixture is diluted with 3M HCl and extracted three times with EtOAc. The extracts are combined, washed twice with water and once with brine, and then dried over Na2SO4, filtered, and concentrated to provide 470 mg of 4-azido-2-ferz-butoxycarbonylamino-butyric acid. To 190 mg (0.77 mmol) of this material, 160 mg (0.85 mmol) of EDC, 120 mg (0.85 mmol) of ΗOBt, and a crystal of DMAP in 1 mL of DMF, is added 0.089 mL (0.77 mmol) of 4-methylpiperidine. The mixture is stirred for 30 min, and then is diluted with EtOAc and washed twice with water, and once with brine. The organic layer is dried over Na2SO4, filtered, and concentrated. Flash chromatography provides 180 mg (73%) of [3-azido-l-(4-methyl-piperidine-l-carbonyl)-propyl]-carbamic acid tert -butyl ester as a colorless oil. To a solution of 180 mg (0.56 mmol) of this material in 1 mL of CH2Cl2 is added 0.13 mL (1.7 mmol) of TFA. The mixture is stirred for 3 h, concentrated, and dissolved in 1 mL of DMF. Triethylamine (0.54 mL, 3.9 mL) and 1-001 (280 mg, 1.1 mmol) are added, and the mixture is stirred for 4h. The mixture is diluted with water and extracted three times with EtOAc. The combined extracts are washed twice with water, and three times with brine, then dried over Na2SO4, filtered, and concentrated. Flash chromatography provides 4-amino-N-[3-azido-l-(4-methyl-piperidine-l-carbonyl)-propyl]- 3,5-dichloro-benzenesulfonamide as a colorless oil. To a solution of 100 mg (0.22 mmol) of the above azide is added 1.5 mL of 1:1 THF/H2O and 0.25 mL (0.25 mmol) of a 1.0 M solution of PMe3 in toluene. The mixuture is stirred overnight, and then concentrated. The residue is diluted with EtOAc and washed three times with water, once with brine, and then dried over MgSO4, filtered, and concentrated to provide 77 mg (81%) of 4-amino-N-[3- amino- 1 -(4-methyl-piperidine- 1 -carbonyl)-propyl] -3 ,5 -dichloro-benzenesulfonamide. To this material (200 mg from multiple experiments, 0.48 mmol) in 2.0 mL of acetic acid at 75 0C is added dropwise 0.064 mL (0.62 mmol) of 2,5-dimethoxytetrahydrofuran. After stirring for 3h, the mixture is diluted with water and is purified by preparative HPLC to provide 56 mg (25%) of Example 235 as a light yellow solid. ESI MS: CaIc: 472.1, Found: 473.3 (M+H)+.
General Method C (Amide formation): A mixture of 0.1 mmol of carboxylic acid and 0.15 mmol of HATU in 1 mL of DMF is added to a mixture of 0.12 mmol of secondary amine and 0.044 mL (0.4 mmol) of tertiary amine base. The mixtures is shaken overnight, concentrated, and purified by preparative HPLC to provide Examples 236 - 361. Example 236: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(morpholin-4-ylcarbonyl)propyl]-lH- indole-4-sulfonamide from 1-102 and morpholine with NMM as base. ESI MS CaIc: 441.2; Found: 442.1 (M+Η)+.
Example 237: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methyl-3,6-dihydropyridin-l(2H)- yl)carbonyl]propyl}-lH-indole-4-sulfonamide from 1-102 and 1-033 with Et3N as base. ESI MS CaIc: 451.2; Found: 452.2 (M+Η)+.
Example 238: Λ^-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-lH-indole- 4-sulfonamide from 1-102 and azepane with NMM as base. ESI MS CaIc: 453.2; Found: 454.1 (M+Η)+.
Example 239: Λ^-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-lH-indole- 6-sulfonamide from 1-101 and azepane with NMM as base. ESI MS CaIc: 453.2; Found: 454.2 (M+Η)+.
Example 240: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(2-methylpiperidin-l-yl)carbonyl] propyl}- lH-indole-4-sulfonamide from 1-102 and 2-methylpiperidine with NMM as base. ESI MS CaIc: 453.2; Found: 454.1 (M+Η)+.
Example 241: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(2-methylpiperidin-l-yl)carbonyl] propyl}- lH-indole-6-sulfonamide from I- 101 and 2-methylpiperidine with NMM as base. ESI MS CaIc: 453.2; Found: 454.2 (M+Η)+. Example 242: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-methylpiperidin-l-yl)carbonyl] propyl}- lH-indole-4-sulfonamide from 1-102 and 3-methylpiperidine with NMM as base. ESI MS CaIc: 453.2; Found: 454.1 (M+Η)+.
Example 243: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-methylpiperidin-l-yl)carbonyl] propyl}- lH-indole-6-sulfonamide from I- 101 and 3-methylpiperidine with NMM as base. ESI MS CaIc: 453.2; Found: 454.2 (M+Η)+.
Example 244: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-oxopiperidin-l-yl)carbonyl] propyl}- lH-indole-4-sulfonamide from 1-102 and 4-oxopiperidine hydrate with NMM as base. ESI MS CaIc: 453.2; Found: 454.1 (M+Η)+.
Example 245: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperazin-l-yl)carbonyl] propyl}- lH-indole-4-sulfonamide from 1-102 and 4-methylpiperazine with NMM as base. ESI MS CaIc: 454.2; Found: 455.2 (M+Η)+.
Example 246: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(l,4-oxazepan-4-ylcarbonyl)propyl]-lH- indole-4-sulfonamide from 1-102 and homomorpholine with NMM as base. ESI MS CaIc: 455.2; Found: 456.2 (M+Η)+.
Example 247: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-hydroxypiperidin-l-yl)carbonyl] propyl}-lH-indole-4-sulfonamide from 1-102 and 3-hydroxypiperidine with NMM as base. ESI MS CaIc: 455.2; Found: 456.2 (M+Η)+. Example 248: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-hydroxypiperidin-l-yl)carbonyl] propyl}-lH-indole-4-sulfonamide from 1-102 and 4-hydroxypiperidine with NMM as base. ESI MS CaIc: 455.2; Found: 456.2 (M+Η)+.
Example 249: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-fluoropiperidin-l-yl)carbonyl] propyl}-lH-indole-4-sulfonamide from 1-102 and 4-fluoropiperidine with NMM as base. ESI MS CaIc: 457.2; Found: 458.2 (M+Η)+.
Example 250: N-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-2-chloro- 6-methylbenzenesulfonamide from 1-099 and azepane with NMM as base. ESI MS CaIc: 462.1; Found: 463.2 (M+Η)+.
Example 251: 2-chloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(2-methylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide from 1-099 and 2-methylpiperidine with NMM as base. ESI MS CaIc: 462.2; Found: 463.1 (M+Η)+.
Example 252: 2-chloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-methylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide from 1-099 and 3-methylpiperidine with NMM as base. ESI MS CaIc: 462.2; Found: 463.1 (M+Η)+.
Example 253: Λ7-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl) propyl]-lH-indole-4-sulfonamide from 1-102 and 6-azaspiro[2.5]octane with NMM as base. ESI MS CaIc: 465.2; Found: 466.2 (M+Η)+. Example 254: N-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl) propyl]-lH-indole-6-sulfonamide from 1-101 and 6-azaspiro[2.5]octane with NMM as base. ESI MS CaIc: 465.2; Found: 466.2 (M+Η)+.
Example 255: Λ?-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methyl-l,4-diazepan-l-yl) carbonyl]propyl}-lH-indole-4-sulfonamide from 1-102 and 4-methyll,4-diazepane with NMM as base. ESI MS CaIc: 468.2; Found: 469.2 (M+Η)+.
Example 256: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(5-oxo-l,4-diazepan-l-yl)carbonyl] propyl}- lH-indole-4-sulfonamide from 1-102 and 5-oxo-l,4-diazepane with NMM as base. ESI MS CaIc: 468.2; Found: 469.2 (M+Η)+.
Example 257: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[2-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 2-hydroxymethyl- piperidine with NMM as base. ESI MS CaIc: 469.2; Found: 470.2 (M+Η)+.
Example 258: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[3-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 3-hydroxymethyl- piperidine with NMM as base. ESI MS CaIc: 469.2; Found: 470.2 (M+Η)+.
Example 259: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-hydroxymethyl- piperidine with NMM as base. ESI MS CaIc: 469.2; Found: 470.1 (M+Η)+. Example 260: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(hydroxymethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-6-sulfonamide from I- 101 and 4-hydroxymethyl- piperidine with NMM as base. ESI MS CaIc: 469.2; Found: 470.2 (M+Η)+.
Example 261: Λ?-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl) propyl]-2-chloro-6-methylbenzenesulfonamide from 1-099 and 6-azaspiro- [2.5]octane with NMM as base. ESI MS CaIc: 474.2; Found: 475.2 (M+Η)+.
Example 262: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-cyclohexyl-Λ7-methylbutanamide from 1-099 and cyclohexyl-N-methyl-amine with NMM as base. ESI MS CaIc: 476.2; Found: 477.2 (M+Η)+.
Example 263: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-propylpiperidin-l-yl)carbonyl] propyl}-lH-indole-4-sulfonamide from 1-102 and 4-propylpiperidine with NMM as base. ESI MS CaIc: 481.2; Found: 482.1 (M+Η)+.
Example 264: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-propylpiperidin-l-yl)carbonyl] propyl}- lH-indole-6-sulfonamide from I- 101 and 4-propylpiperidine with NMM as base. ESI MS CaIc: 481.2; Found: 482.2 (M+Η)+.
Example 265: 2,6-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-methylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide from I- 100 and 3-methylpiperidine with NMM as base. ESI MS CaIc: 482.1; Found: 483.1 (M+Η)+. Example 266: Λ^-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]-2,6- dichlorobenzenesulfonamide from 1-100 and azepane with NMM as base. ESI MS CaIc: 482.1; Found: 483.1 (M+Η)+.
Example 267: Λ^-{l-[(4-acetylpiperazin-l-yl)carbonyl]-3-(2-cyano-lH-pyrrol-l-yl) propyl}- lH-indole-4-sulfonamide from 1-102 and 4-acetylpiperazine with NMM as base. ESI MS CaIc: 482.2; Found: 483.2 (M+Η)+.
Example 268: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4,4-difluoropiperidin-l-yl)carbonyl] propyl}- lH-indole-4-sulfonamide from 1-102 and 4,4-difluoropiperidine with NMM as base. ESI MS CaIc: 482.2; Found: 483.2 (M+Η)+.
Example 269: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(2-hydroxyethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-(2-hydroxyethyl)- piperidine with NMM as base. ESI MS CaIc: 483.2; Found: 484.2 (M+Η)+.
Example 270: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(methoxymethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-(methoxymethyl)- piperidine with NMM as base. ESI MS CaIc: 483.2; Found: 484.2 (M+Η)+.
Example 271: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(2-hydroxyethyl)piperazin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-(2-hydroxyethyl)- piperazine with NMM as base. ESI MS CaIc: 484.2; Found: 485.2 (M+Η)+. Example 272: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-ΛKpyridin-2-ylmethyl)butanamide from 1-099 and pyridine-2-yl- methyl-amine with NMM as base. ESI MS CaIc: 485.1; Found: 486.2 (M+Η)+.
Example 273: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-ΛKpyridin-3-ylmethyl)butanamide from 1-099 and pyridine-3-yl- methyl-amine with NMM as base. ESI MS CaIc: 485.1; Found: 486.1 (M+Η)+.
Example 274: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydroisoquinolin-2(lH)- ylcarbonyl)propyl]-lH-indole-4-sulfonamide from 1-102 and 3,4-tetrahydro- isoquinoline with NMM as base. ESI MS CaIc: 487.2; Found: 488.1 (M+Η)+.
Example 275: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydroisoquinolin-2(lH)-yl carbonyl)propyl]-lH-indole-6-sulfonamide from I- 101 and tetrahydroisoquinoline with NMM as base. ESI MS CaIc: 487.2; Found: 488.2 (M+Η)+.
Example 276: 2-chloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-propylpiperidin-l-yl) carbonyl]propyl}-6-methylbenzenesulfonamide from 1-099 and 4-propyl-piperidine with NMM as base. ESI MS CaIc: 490.2; Found: 491.2 (M+Η)+.
Example 277: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3-methyl-5,6-dihydro[l,2,4]triazole [4,3- a]pyrazin-7(8H)-ylcarbonyl)propyl]-lH-indole-4-sulfonamide from 1-102 and 3- methyl-5,6,7,8-tetrahydro-l,2,4-triazolo[4,3-α]pyrazine hydrochloride with Et3N as base. ESI MS CaIc: 492.2; Found: 493.3 (M+Η)+. Example 278: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)-octahydroisoquinolin-2(lH)-yl carbonyl]propyl}-lH-indole-4-sulfonamide from 1-102 and cis-decahydro- isoquinoline with NMM as base. ESI MS CaIc: 493.2; Found: 494.2 (M+Η)+.
Example 279: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)-octahydroisoquinolin-2(lH)-yl carbonyl]propyl}-lH-indole-6-sulfonamide from 1-100 and cis-ocatahydro- isoquinoline with NMM as base. ESI MS CaIc: 493.2; Found: 494.3 (M+Η)+.
Example 280: Λ^-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl) propyl]-2,6-dichlorobenzenesulfonamide from 1-100 and 6-azaspiro[2.5]octane with NMM as base. ESI MS CaIc: 494.1; Found: 495.1 (M+Η)+.
Example 281: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(octahydro-2H-pyrido[l,2-a]pyrazin-2- ylcarbonyl)propyl]-lH-indole-4-sulfonamide from 1-102 and octahydro-2Η- pyrido[l,2-a]pyrazine with NMM as base. ESI MS CaIc: 494.2; Found: 495.2 (M+H)+.
Example 282: 2-chloro-Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydroisoquinolin-2(lH)- ylcarbonyl)propyl]-6-methylbenzenesulfonamide from 1-099 and 3,4- tetrahydroisoquinoline with NMM as base. ESI MS CaIc: 496.1; Found: 497.2 (M+Η)+.
Example 283: Λ^-{l-[(4-acetyl-l,4-diazepan-l-yl)carbonyl]-3-(2-cyano-lH-pyrrol-l-yl) propyl}-lH-indole-4-sulfonamide from 1-102 and 4-acetyl-l,4-diazepane with NMM as base. ESI MS CaIc: 496.2; Found: 497.2 (M+Η)+. Example 284: 4-amino-3,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(2-methyl- piperidin-l-yl)carbonyl]propyl}benzenesulfonamide from 1-098 and 2-methyl- piperidine with NMM as base. ESI MS CaIc: 497.1 ; Found: 498.1 (M+Η)+.
Example 285: 4-amino-3,5-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3-methyl- piperidin-l-yl)carbonyl]propyl}benzenesulfonamide from 1-098 and 3-methyl- piperidine with NMM as base. ESI MS CaIc: 497.1; Found: 498.1 (M+Η)+.
Example 286: 4-amino-Λ^-[l-(azepan-l-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l-yl)propyl]- 3,5-dichlorobenzenesulfonamide from 1-098 and azepane with NMM as base. ESI MS CaIc: 497.1 ; Found: 498.1 (M+Η)+.
Example 287: methyl l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidine-4-carboxylate from 1-102 and methyl piperidine-4-carboxylate with NMM as base. ESI MS CaIc: 497.2; Found: 498.1 (M+Η)+.
Example 288: methyl l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-6-ylsulfonyl)amino] butanoyl}piperidine-4-carboxylate from 1-100 and 4-propylpiperidine with NMM as base. ESI MS CaIc: 497.2; Found: 498.2 (M+Η)+.
Example 289: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(l,4-dioxa-8-azaspiro[4.5]dec-8-yl carbonyl)propyl]-lH-indole-4-sulfonamide from 1-102 and l,4-dioxa-8-aza-spiro- [4.5]decane with NMM as base. ESI MS CaIc: 497.2; Found: 498.2 (M+Η)+. Example 290: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(l-hydroxy-l-methylethyl) piperidin- l-yl]carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-( 1 -hydroxy- 1- methylehtyl)piperidine with NMM as base. ESI MS CaIc: 497.2; Found: 498.3 (M+Η)+.
Example 291: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-(3-methylbenzyl)butanamide from 1-099 and (3-methylbenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 498.2; Found: 499.1 (M+Η)+.
Example 292: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-.<V-(4-methylbenzyl)butanamide from 1-099 and 4-methylbenzyl- methyl-amine with NMM as base. ESI MS CaIc: 498.2; Found: 499.1 (M+Η)+.
Example 293: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-N-methyl-Λ4(lS)-l-phenylethyl]butanamide from 1-099 and methyl-(lS)-l- phenethylamine with NMM as base. ESI MS CaIc: 498.2; Found: 499.1 (M+Η)+.
Example 294: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ^-(2-fluorobenzyl)-Λ^-methylbutanamide from 1-099 and (2-fluorobenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 502.1 ; Found: 503.0 (M+Η)+.
Example 295: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ^-(3-fluorobenzyl)-Λ^-methylbutanamide from 1-099 and (3-fluorobenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 502.1 ; Found: 503.1 (M+Η)+. Example 296: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ^-(4-fluorobenzyl)-Λ^-methylbutanamide from 1-099 and (4-fluorobenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 502.1; Found: 503.1 (M+Η)+.
Example 297: 2-chloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)-octahydroisoquinolin-
2(lH)-ylcarbonyl]propyl}-6-methylbenzenesulfonamide from 1-099 and cis-deca- hydroisoquinoline with NMM as base. ESI MS CaIc: 502.2; Found: 503.2 (M+Η)+.
Example 298: methyl l-[2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH- pyrrol-l-yl)butanoyl]piperidine-4-carboxylate from 1-099 and methyl piperidine-4- carboxylate with NMM as base. ESI MS CaIc: 506.1; Found: 507.2 (M+Η)+.
Example 299: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(trifluoromethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-(trifluoromethyl)- piperidine with NMM as base. ESI MS CaIc: 507.2; Found: 508.1 (M+Η)+.
Example 300: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(trifluoromethyl)piperidin-l-yl] carbonyl}propyl]-lH-indole-6-sulfonamide from 1-101 and 4-(trifluoromethyl)- piperidine with NMM as base. ESI MS CaIc: 507.2; Found: 508.2 (M+Η)+.
Example 301: 4-amino-N-[l-(6-azaspiro[2.5]oct-6-ylcarbonyl)-3-(2-cyano-lH-pyrrol-l- yl)propyl]-3,5-dichlorobenzenesulfonamide from 1-098 and aza-spiro[2.5]octane with NMM as base. ESI MS CaIc: 509.1; Found: 510.1 (M+Η)+. Example 302: methyl (l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-4-ylidene)acetate from 1-102 and piperidin-4-ylidene-acetic acid methyl ester with NMM as base. ESI MS CaIc: 509.2; Found: 510.2 (M+Η)+.
Example 303: 2,6-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-propylpiperidin-l-yl) carbonyl]propyl}benzenesulfonamide from I- 100 and 4-propylpiperidine with NMM as base. ESI MS CaIc: 510.1; Found: 511.1 (M+Η)+.
Example 304: 3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-4-yl)propanamide from 1-102 and 3-(piperidine-4-yl)- propanamide with NMM as base. ESI MS CaIc: 510.2; Found: 511.2 (M+Η)+.
Example 305: methyl (l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-2-yl)acetate from 1-102 and piperidin-2-yl-acetic acid methyl ester with NMM as base. ESI MS CaIc: 511.2; Found: 512.2 (M+Η)+.
Example 306: methyl (l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-3-yl)acetate from 1-102 and piperidin-3-yl-acetic acid methyl ester with NMM as base. ESI MS CaIc: 511.2; Found: 512.2 (M+Η)+.
Example 307: methyl (l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-4-yl)acetate from 1-102 and piperidin-4-yl-acetic acid methyl ester with NMM as base. ESI MS CaIc: 511.2; Found: 512.2 (M+Η)+. Example 308: 3-chloro-Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6-dihydro[l,2,4]triazolo[4,3- α]pyrazin-7(8H)-ylcarbonyl)propyl]-lH-indole-4-sulfonamide from 1-103 and 5,6,7,8-tetrahydro-l,2,4-triazolo[4,3-α]pyrazine with Et3N as base. ESI MS CaIc: 512.1 ; Found: 513.2 (M+Η)+.
Example 309: 4-amino-3,5-dichloro-Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(hydroxy- methyl)piperidin-l-yl]carbonyl}propyl]benzenesulfonamide from 1-098 and A- hydroxymethylpiperidine with NMM as base. ESI MS CaIc: 513.1 ; Found: 514.1 (M+Η)+.
Example 310: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-(2-methoxybenzyl)-.<V-methylbutanamide from 1-099 and (2-methoxy- benzyl)-methyl-amine with NMM as base. ESI MS CaIc: 514.1 ; Found: 515.1 (M+Η)+.
Example 311: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-(3-methoxybenzyl)-.<V-methylbutanamide from 1-099 and (3-methoxy- benzyl)-methyl-amine with NMM as base. ESI MS CaIc: 514.1 ; Found: 515.1 (M+Η)+.
Example 312: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-(4-methoxybenzyl)-.<V-methylbutanamide from 1-099 and (2-methoxy- benzyl)-methyl-amine with NMM as base. ESI MS CaIc: 514.1 ; Found: 515.2 (M+Η)+. Example 313: 2,6-dichloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydroisoquinolin- 2(lH)-ylcarbonyl)propyl]benzenesulfonamide from I- 100 and tetrahydro- isoquinoline with NMM as base. ESI MS CaIc: 516.1 ; Found: 517.1 (M+Η)+.
Example 314: 2-chloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(trifluoromethyl) piperidin- l-yl]carbonyl}propyl]-6-methylbenzenesulfonamide from 1-099 and A- (trifluoromethyl)piperidine with NMM as base. ESI MS CaIc: 516.1 ; Found: 517.1 (M+Η)+.
Example 315: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-phenylpiperazin-l-yl)carbonyl] propyl}-lH-indole-4-sulfonamide from 1-102 and 4-phenylpiperazine with NMM as base. ESI MS CaIc: 516.2; Found: 517.3 (M+Η)+.
Example 316: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(methylsulfonyl)piperidin-l- yl]carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-methanesulfonyl- piperidine (US2003/100567A1) with Et3N as base. ESI MS CaIc: 517.2; Found: 518.2 (M+Η)+
Example 317: Λ^-(2-chlorobenzyl)-2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2- cyano-lH-pyrrol-l-yl)-Λ7-methylbutanamide from 1-099 and (2-chlorobenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 518.1 ; Found: 519.1 (M+Η)+.
Example 318: Λ^-(3-chlorobenzyl)-2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2- cyano-lH-pyrrol-l-yl)-Λ7-methylbutanamide from 1-099 and (3-chlorobenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 518.1 ; Found: 519.0 (M+Η)+. Example 319: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-pyrimidin-2-ylpiperazin-l-yl) carbonyl]propyl}-lH-indole-4-sulfonamide from 1-102 and 4-pyrimidin-2-yl- piperiazine with NMM as base. ESI MS CaIc: 518.2; Found: 518.2 (M+Η)+.
Example 320: 2,6-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)-octahydro- isoquinolin-2(lH)-ylcarbonyl]propyl}benzenesulfonamide from I- 100 and cis- decahydroisoquinoline with NMM as base. ESI MS CaIc: 522.1; Found: 523.2 (M+Η)+.
Example 321: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(l,3-thiazol-2-yl)piperazin-l-yl] carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-(l,3-thiazol-2-yl)- piperazine with NMM as base. ESI MS CaIc: 523.2; Found: 524.2 (M+Η)+.
Example 322: methyl (2£>3-(l-{4-(2-cyano-lH-pyrπ)l-l-yl)-2-[(lH-indol-4- ylsulfonyl)amino]butanoyl}piperidin-3-yl)prop-2-enoate from 1-102 and 1-032 with Et3N as base. ESI MS CaIc: 523.2; Found: 524.2 (M+Η)+.
Example 323: Λ^-[2-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-2-yl)ethyl]acetamide from 1-102 and N-[2-(piperidine-2-yl) ethyl] acetamide with NMM as base. ESI MS CaIc: 524.2; Found: 525.2 (M+Η)+.
Example 324: Λ^-[2-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-4-yl)ethyl]acetamide from 1-102 and N-[2-(piperidine-4-yl) ethyl] acetamide with NMM as base. ESI MS CaIc: 524.2; Found: 525.2 (M+Η)+. Example 325: 4-amino-3,5-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-propyl- piperidin-l-yl)carbonyl]propyl}benzenesulfonamide from 1-098 and 4-propyl- piperidine with NMM as base. ESI MS CaIc: 525.1; Found: 526.1 (M+Η)+.
Example 326: methyl 3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}piperidin-3-yl)propanoate from 1-102 and piperidin-3-yl- propionic acid methyl ester with NMM as base. ESI MS CaIc: 525.2; Found: 526.3 (M+Η)+.
Example 327: methyl 3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}piperidin-4-yl)propanoate from 1-102 and piperidin-4-yl- propionic acid methyl ester with NMM as base. ESI MS CaIc: 525.2; Found: 526.3 (M+Η)+.
Example 328: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6-dihydro[l,2,4]triazolo[4,3-a] pyrazin-7(8H)-ylcarbonyl)propyl]-lH-indole-4-sulfonamide from 1-102 and 5,6,7,8-tetrahydro-l,2,4-triazolo[4,3-α]pyrazine with Et3N as base. ESI MS CaIc: 478.2; Found: 479.2 (M+Η)+.
Example 329: methyl l-[4-(2-cyano-lH-pyrrol-l-yl)-2-{[(2,6-dichlorophenyl)sulfonyl] amino}butanoyl]piperidine-4-carboxylate from 1-100 and methyl piperidine-4- carboxylate with NMM as base. ESI MS CaIc: 526.1 ; Found: 527.1 (M+Η)+. Example 330: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ^-(2-methoxy-5-methylbenzyl)-Λ^-methylbutanamide from 1-099 and (2- methoxy-5-methylbenzyl)-methyl-amine with NMM as base. ESI MS CaIc: 528.2; Found: 529.2 (M+Η)+.
Example 331: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-(2-naphthylmethyl)butanamide from 1-099 and methyl- naphthalene-2-ylmethyl-amine with NMM as base. ESI MS CaIc: 534.2; Found:
535.1 (M+Η)+.
Example 332: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-(l-naphthylmethyl)butanamide from 1-099 and methyl- naphthalene- 1-ylmethyl-amine with NMM as base. ESI MS CaIc: 534.3; Found:
535.2 (M+Η)+.
Example 333: 2,6-dichloro-Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(trifluoromethyl) piperidin-l-yl]carbonyl}propyl]benzenesulfonamide from 1-100 and (4-trifluoro- methyl)piperidine with NMM as base. ESI MS CaIc: 536.1; Found: 537.1 (M+Η)+.
Example 334: methyl 4-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}piperidin-4-yl)butanoate from 1-102 and methyl piperidine-4- butanoate with NMM as base. ESI MS CaIc: 539.2; Found: 540.1 (M+Η)+. Example 335: methyl 4-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}piperidin-3-yl)butanoate from 1-102 and methyl piperidine-3- butanoate with NMM as base. ESI MS CaIc: 539.2; Found: 540.1 (M+Η)+.
Example 336: l-[2-{[(4-amino-3,5-dichlorophenyl)sulfonyl]amino}-4-(2-cyano-lH- pyrrol-l-yl)butanoyl]-Λ7-methylpiperidine-4-carboxamide from 1-098 and N- methyl piperidine-4-carboxamide with NMM as base. ESI MS CaIc: 540.1; Found:
541.1 (M+Η)+.
Example 337: methyl l-[2-{[(4-amino-3,5-dichlorophenyl)sulfonyl]amino}-4-(2-cyano- lH-pyrrol-l-yl)butanoyl]piperidine-4-carboxylate from 1-098 and methyl piperidine-4-carboxylate with NMM as base. ESI MS CaIc: 541.1; Found: 542.1 (M+Η)+.
Example 338: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-(3,4-dimethoxybenzyl)-.<V-methylbutanamide from 1-099 and (3,4- dimethoxybenzyl)-methyl-amine with NMM as base. ESI MS CaIc: 544.2; Found:
545.2 (M+Η)+.
Example 339: Λ^-{l-[(4-benzyl-l,4-diazepan-l-yl)carbonyl]-3-(2-cyano-lH-pyrrol-l-yl) propyl}- lH-indole-4-sulfonamide from 1-102 and 4-benzyl-l,4-diazepane with NMM as base. ESI MS CaIc: 544.2; Found: 545.3 (M+Η)+.
Example 340: methyl 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,2,3,4-tetrahydroisoquinoline-6-carboxylate from 1-102 and 1,2,3,4- tetrahydro-isoquinoline-6-carboxylic acid methyl ester with iPr2NEt as base. ESI MS CaIc: 545.2; Found: 546.3 (M+H)+.
Example 341: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,2,3,4-tetrahydroisoquinoline-7-carboxylic acid methyl ester from I- 102 and l,2,3,4-Tetrahydro-isoquinoline-7-carboxylic acid methyl ester with 1Pr2NEt as base. ESI MS CaIc: 545.2; Found: 546.2 (M+Η)+.
Example 342: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-N-[4-(lH-imidazol-l-yl)benzyl]-N-methylbutanamide from 1-099 and [4 (1Η- imidazol-l-yl)benzyl]-methyl-amine with NMM as base. ESI MS CaIc: 550.2; Found: 551.2 (M+H)+.
Example 343: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-[4-(lH-pyrazol-l-yl)benzyl]butanamide from 1-099 and methyl-(4- pyrazol-l-yl-benzyl)amine with NMM as base. ESI MS CaIc: 550.2; Found: 551.2 (M+Η)+.
Example 344: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-[3-(trifluoromethyl)benzyl]butanamide from 1-099 and 3- (trifluoromethyl)benzyl-methyl-amine with NMM as base. ESI MS CaIc: 552.1 ; Found: 553.1 (M+Η)+.
Example 345: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-[4-(trifluoromethyl)benzyl]butanamide from 1-099 and 4(- trifluoromethyl)benzyl-methyl-amine with NMM as base. ESI MS CaIc: 552.1 ; Found: 553.1 (M+H)+.
Example 346: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ^-methyl-Λ^-[(l-methyl-l,2,3,4-tetrahydroquinolin-6-yl)methyl]butanamide from 1-099 and (l-methyl-l,2,3,4-tetrahydroquinolin-6-yl)methyl-amine with NMM as base. ESI MS CaIc: 553.2; Found: 554.2 (M+Η)+.
Example 347: 3-[(cis)-l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}-4-methylpiperidin-3-yl]propanoic acid from 1-102 and 1-031 with Et3N as base. ESI MS CaIc: 553.2; Found: 554.3 (M+Η)+.
Example 348: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-(3-pyridin-3-ylbenzyl)butanamide from 1-099 and 3-(pyridin-3- yl)benzyl-methyl-amine with NMM as base. ESI MS CaIc: 561.2; Found: 562.2 (M+Η)+.
Example 349: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-.<V-(4-pyridin-4-ylbenzyl)butanamide from 1-099 and (4-pyridine-4- yl)benzyl-methyl-amine with NMM as base. ESI MS CaIc: 561.2; Found: 562.2 (M+Η)+.
Example 350: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-(4-pyrimidin-5-ylbenzyl)butanamide from 1-099 and (4-pyrimidin- 4-yl)-methyl-amine with NMM as base. ESI MS CaIc: 562.0; Found: 563.2 (M+Η)+. Example 351: Λ^-(2-bromobenzyl)-2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2- cyano-lH-pyrrol-l-yl)-Λ7-methylbutanamide from 1-099 and methyl-(2- bromobenzyl)amine with NMM as base. ESI MS CaIc: 562.0; Found: 563.0 (M+Η)+.
Example 352: Λ^-(3-bromobenzyl)-2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2- cyano-lH-pyrrol-l-yl)-Λ7-methylbutanamide from 1-099 and (3-bromobenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 562.0; Found: 563.0 (M+Η)+.
Example 353: Λ^-(4-bromobenzyl)-2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2- cyano-lH-pyrrol-l-yl)-Λ7-methylbutanamide from 1-099 and (4-bromobenzyl)- methyl-amine with NMM as base. ESI MS CaIc: 562.0; Found: 563.0 (M+Η)+.
Example 354: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-(3-pyrimidin-5-ylbenzyl)butanamide from 1-099 and (3-pyrimidin- 3-yl)benzyl-methyl-amine with NMM as base. ESI MS CaIc: 562.2; Found: 563.2 (M+Η)+.
Example 355: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-N-methyl-N-[3-(5-methyl-l,2,4-oxadiazol-3-yl)benzyl]butanamide from 1-099 and 3-(5-methyl-l,2,4-oxadiazol-3-yl) benzyl-methylamine with NMM as base. ESI MS CaIc: 566.2; Found: 567.1 (M+Η)+. Example 356: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-N-methyl-N-[4-(5-methyl-l,2,4-oxadiazol-3-yl)benzyl]butanamide from 1-099 and methyl-[4-(5-methyl-l,2,4-oxadiazol-3-yl)-benzyl]-amine with NMM as base. ESI MS CaIc: 566.2; Found: 567.1 (M+Η)+.
Example 357: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ^-methyl-Λ^-(3-piperidin-l-ylbenzyl)butanamide from 1-099 and 3-(piperidin- l-yl)benzyl-methyl-amine with NMM as base. ESI MS CaIc: 567.2; Found: 568.2 (M+Η)+.
Example 358: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-(3-morpholin-4-ylbenzyl)butanamide from 1-099 and (3- morpholin-4-ylbenzyl)-methyl-amine with NMM as base. ESI MS CaIc: 569.2; Found: 570.2 (M+Η)+.
Example 359: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-[3-(morpholin-4-ylmethyl)benzyl]butanamide from 1-099 and 3- (morpholin-4-ylmehtyl)benzyl-methyl-amine with NMM as base. ESI MS CaIc: 583.2; Found: 584.2 (M+Η)+.
Example 360: Λ?-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(3-pyrazin-2-yl-l,2,4-oxadiazol-5- yl)piperidin-l-yl]carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-(3- pyrazine-2-yl-l,2,4-oxadiazol-5-yl)piperidine with NMM as base. ESI MS CaIc: 585.2; Found: 586.2 (M+Η)+. Example 361: ethyl 2-[(2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}-l,2,3,4-tetrahydroisoquinolin-7-yl)oxy]-2-methylpropanoate from 1-102 and 1-039 with Et3N as base. ESI MS CaIc: 617.2; Found: 618.3 (M+Η)+.
Example 362: 4-amino-3,5-dichloro-N-[l-(3,4-dihydroisoquinolin-2(lH)-ylcarbonyl)-3- (2-nitro-lH-imidazol-l-yl)propyl]benzenesulfonamide
Figure imgf000227_0001
To 25 mg (0.057 mmol) of 1-096 in 1.25 mL of 40% DMF in DCE is added 58 mg (0.092 mmol) of PS-carbodimide and 0.25 mL of a 0.32 M solution of ΗOBt in 50% DMF/DCE. The mixture is shaken for 30 min, and then 0.1 mL of a 0.51 M solution of 1,2,3,4- tetrahydroisoquinoline (0.051 mmol) in DMF is added. The mixture is stirred for 36 h, and then O.lOg of PS-trisamine (0.42 mmol) and 0.13 g of MP-carbonate (0.42 mmol) are added. The mixture is shaken for an additional 24 h, and then filtered. The filtrate is evaporated to provide Example 362. ESI MS. CaIc: 552.1; Found: 553.4 (M+Η)+.
General Method D (Amide formation): A mixture of 1 equivalent of a carboxylic acid, ≥1.2 equivalents of EDC, and >1.2 equivalents of HOBt is stirred in DMF for 20 min. Then, >1.2 equivalents of secondary amine are added, and the mixture is heated for 10 min at 70 9C in a microwave reactor. The mixture is then diluted with CH2CI2 and washed with saturated NaHCU3 and water. The organic layer is dried over Na2SO4, filtered, and concentrated. Purification by flash chromatography or preparative HPLC provides Examples 363 - 367.
Example 363: 4-amino-3,5-dichloro-N-[3-(2-nitro-lH-imidazol-l-yl)-l-{[4-(trifluoro- methyl)piperidin-l-yl]carbonyl}propyl]benzenesulfonamide from 1-096 and A- trifluoromethylpiperidine. ESI MS. CaIc: 572.1; Found: 573.4 (M+Η)+.
Example 364: 4-amino-3,5-dichloro-Λ^-{l-[(4,4-dimethylpiperidin-l-yl)carbonyl]-3-(2- nitro-lH-imidazol-l-yl)propyl}benzenesulfonamide from 1-096 and 4,4- dimethylpiperidine. ESI MS. CaIc: 532.1; Found: 533.4 (M+Η)+.
Example 365: 4-amino-3,5-dichloro-Λ^-{3-(2-nitro-lH-imidazol-l-yl)-l-[(cis)-octa- hydroisoquinolin-2(lH)-ylcarbonyl]propyl}benzenesulfonamide from 1-096 and cώ-decahydroisoquinoline. ESI MS. CaIc: 558.1 ; Found: 559.5 (M+Η)+.
Example 366: 4-amino-3,5-dichloro-Λ^-{3-(2-nitro-lH-imidazol-l-yl)-l-[(trans)-octa- hydroisoquinolin-2(lH)-ylcarbonyl]propyl}benzenesulfonamide from 1-096 and fraws-decahydroisoquinoline. ESI MS. CaIc: 558.1 ; Found: 559.5 (M+Η)+.
Example 367: 4-amino-3,5-dichloro-N-[l-{[4-(hydroxymethyl)piperidin-l-yl]carbonyl} - 3-(2-nitro-lH-imidazol-l-yl)propyl]benzenesulfonamide from 1-096 and A- (hydroxymethyl)piperidine. ESI MS. CaIc: 534.1; Found: 535.4 (M+Η)+.
General Method E (Amide formation): A mixture of 1 equivalent of a carboxylic acid, ≥1.2 equivalents of EDC, and >1.2 equivalents of HOBt is stirred in DMF for 20 min when >1.2 equivalents secondary amine is added, and the mixture is stirred for 2 - 24 h. The mixture is purified directly by preparative HPLC, or is subjected to an aqueous workup (water, NaHCO3, and brine) before being purified by flash chromatography or preparative HPLC to access Examples 368 - 401.
Example 368: 2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH-pyrrol-l- yl)-Λ7-methyl-Λ7-[2-(trifluoromethyl)benzyl]butanamide from 1-099 and methyl-(2- trifluoromethyl-benzyl)- amine with the addition of 0.2 equivalents of DMAP. ESI MS. CaIc: 552.1; Found: 553.3 (M+Η)+.
Example 369: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,6-dihydropyridin-l(2H)-ylcarbonyl) propyl]-lH-indole-4-sulfonamide from 1-102 and 1,2,3,6-tetrahydropyridine. ESI MS CaIc: 437.2; Found: 438.2 (M+Η)+.
Example 370: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(piperidin-l-ylcarbonyl)propyl]-lH- indole-4-sulfonamide from 1-102 and piperidine. ESI MS CaIc: 439.2; Found: 440.1 (M+Η)+.
Example 371: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(piperidin-l-ylcarbonyl)propyl]-lH- indole-6-sulfonamide from 1-101 and piperidine. ESI MS CaIc: 439.2; Found: 440.3 (M+Η)+.
Example 372: 2-chloro-N-[3-(2-cyano-lH-pyrrol-l-yl)-l-(piperidin-l-ylcarbonyl) propyl]-6-methylbenzenesulfonamide from 1-099 and piperidine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 448.1 ; Found: 449.3 (M+Η)+. Example 373: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-oxoazepan-l-yl)carbonyl]propyl}- lH-indole-4-sulfonamide from 1-102 and 4-perhydroazepanone hydrochloride (Magical Scientific). ESI MS CaIc: 467.2; Found: 468.3 (M+Η)+.
Example 374: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[(trαns)-3-hydroxy-4-methyl-piperidin- l-yl]carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 1-034 (50% pure). ESI MS CaIc: 469.2; Found: 470.3 (M+Η)+.
Example 375: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(3,4-dimethylpiperidin-l-yl) carbonyl]propyl}-lH-indole-4-sulfonamide from 1-102 and 3,4-dimethylpiperidine. ESI MS CaIc: 467.2; Found: 468.3 (M+Η)+.
Example 376: Λ^-benzyl-4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-6-ylsulfonyl)amino]-Λ^- methylbutanamide from I- 101 and N-methylbenzylamine. ESI MS CaIc: 475.2; Found: 476.5 (M+Η)+.
Example 377: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6-dihydro-imidazo[4,3-α]pyrazin- 7(8H)-ylcarbonyl)propyl]-lH-indole-4-sulfonamide from 1-102 and 5,6,7,8- tetrahydro-imidazo[l,2-α]pyrazine. ESI MS CaIc: 477.2; Found: 478.4 (M+Η)+.
Example 378: 4-amino-3,5-dichloro-W-[3-(2-cyano-lH-pyrrol-l-yl)-l-(piperidin-l-yl- carbonyl)propyl]benzenesulfonamide from 1-098 and piperidine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 483.1 ; Found: 484.1 (M+Η)+. Example 379: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(l,l-dioxidothiomorpholin-4-yl) carbonyl]propyl}-lH-indole-4-sulfonamide from 1-102 and 1,1-dioxothio- morpholine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc. : 489.1 ; Found: 490.2 (M+Η)+.
Example 380: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)- ylcarbonyl)propyl]-lH-indole-4-sulfonamide from 1-102 and 4,5,6,7-tetrahydro- thieno[3,2-c]pyridine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 493.1; Found: 494.2 (M+Η)+.
Example 381: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(trans)-octahydroisoquinolin-2(lH)- ylcarbonyl]propyl}-lH-indole-6-sulfonamide from 1-101 and /rarø-decahydro- sioquinoline. ESI MS CaIc: 493.2; Found: 494.5 (M+Η)+.
Example 382: 4-amino-3,5-dichloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylene- piperidin-l-yl)carbonyl]propyl}benzenesulfonamide from 1-098 and 4- methylenepiperidine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 495.1; Found: 496.3 (M+Η)+.
Example 383: Λ^-{l-[(2-amino-6,7-dihydro[l,3]thiazolo[5,4-c]pyridin-5(4H)-yl) carbonyl]-3-(2-cyano-lH-pyrrol-l-yl)propyl}-lH-indole-4-sulfonamide from I- 102 and 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridin-2-ylamine (Wallace, T. A. et al. Bioorg. Med. Chem. Lett, 2005, 15, 2253). ESI MS CaIc: 509.1; Found: 510.2 (M+Η)+. Example 384: lH-indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(7-cyano-3,4- dihydro-lH-isoquinoline-2-carbonyl)-propyl]-amide from 1-102 and 7-cyano- 1,2,3,4-tetrahydroisoquinoline (Gruenewald, G. L. et al. J. Med. Chem, 1997, 40, 3997). ESI MS CaIc: 512.2; Found: 513.4 (M+Η)+.
Example 385: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-phenylpiperidin-l-yl)carbonyl] propyl}- lH-indole-4-sulfonamide from 1-102 and 4-phenylpiperidine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 515.2; Found: 516.4 (M+Η)+.
Example 386: 2-{[(4-amino-3,5-dichlorophenyl)sulfonyl]amino}-N-benzyl-4-(2-cyano- lH-pyrrol-l-yl)-Λ7-methylbutanamide from 1-098 and N-methyl-benzylamine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 519.1 ; Found: 520.1 (M+Η)+.
Example 387: ethyl l-[2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH- pyrrol-l-yl)butanoyl]piperidine-3-carboxylate from 1-099 and ethyl piperidine-3- carboxylate with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 520.2; Found: 521.2 (M+Η)+.
Example 388: methyl l-[2-{[(2-chloro-6-methylphenyl)sulfonyl]amino}-4-(2-cyano-lH- pyrrol-l-yl)butanoyl]-4-methylpiperidine-4-carboxylate from 1-099 and ethyl 4- methylpiperidine-4-carboxylate with the addition of 2 equivalents of iPr2NEt. ESI MS CaIc: 520.2; Found: 521.2 (M+Η)+. Example 389: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(3-methyl-l,2,4-oxadiazol-5-yl) piperidin-l-yl]carbonyl}propyl]-lH-indole-4-sulfonamide from 1-102 and 4-(3- methyl-l,2,4-oxadiazol-5-yl)-piperidine with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 521.2; Found: 522.4 (M+Η)+.
Example 390: 4-amino-3,5-dichloro-Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydro- isoquinolin-2(lH)-ylcarbonyl)propyl]benzenesulfonamide from 1-098 and tetrahydroisoquinoline with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 531.1; Found: 532.1 (M+Η)+.
Example 391: lH-indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(7-nitro-3,4-dihydro- lH-isoquinoline-2-carbonyl)-propyl]-amide from 1-102 and 7-nitro-l,2,3,4- tetrahydroisoquinoline (Zhu, Z. et al. J. Med. Chem., 2003, 46, 831). ESI MS CaIc: 532.2; Found: 533.4 (M+Η)+.
Example 392: 4-amino-3,5-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(cis)-octahydro- isoquinolin-2(lH)-ylcarbonyl]propyl}benzenesulfonamide from 1-098 and cis- decahydroisoquinoline with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 537.1; Found: 538.2 (M+Η)+.
Example 393: 4-amino-3,5-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(trans)-octa- hydroisoquinolin-2(lH)-ylcarbonyl]propyl}benzenesulfonamide from 1-098 and fraws-decahydroisoquinoline with the addition of 0.2 equivalents of DMAP. ESI MS CaIc: 537.1; Found: 538.2 (M+Η)+. Example 394: lH-indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(8-nitro-l,3,4,5- tetrahydro-2-benzazepine-2-carbonyl)-propyl]-amide from 1-102 and 8-nitro- 2,3,4,5-tetrahydro-lH-2-benzazepine (prepared by nitration of 2,3,4,5-tetrahydro-lH- 2-benzazepine as in Zhu, Z. et al. J. Med. Chem., 2003, 46, 831). ESI MS CaIc: 546.2; Found: 547.4 (M+Η)+.
Example 395: 4-amino-3,5-dichloro-Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(trifluoro- methyl)piperidin-l-yl]carbonyl}propyl]benzenesulfonamide from 1-098 and A- (trifluoromethyl)piperidine hydrochloride with the addition of 2 equivalents of iPr2NEt. ESI MS CaIc: 551.1; Found: 552.2 (M+Η)+.
Example 396: 4-[4-(2-Cyano-pyrrol-l-yl)-2-(lH-indole-4-sulfonylamino)-butyryl]- perhydro-l,4-diazepine-l-carboxylic acid tert-Xmty\ ester from 1-102 and perhydro-l^-diazepine-l-carboxylic acid tert-buty\ ester. ESI MS CaIc: 554.2; Found: 555.4 (M+Η)+.
Example 397: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,2,3,4-tetrahydroisoquinoline-7-sulfonamide from 1-102 and 1,2,3,4- tetrahydro-isoquinoline-7-sulfonic acid amide hydrochloride (Pendelton, R. G., et al. J. Pharmacol. Exp. Ther., 1979, 2OS, 24) with the addition of 3 equivalents of NMM. ESI MS CaIc: 566.1; Found: 567.2 (M+Η)+.
Example 398: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,2,3,4-tetrahydroisoquinoline-7-sulfonic acid from 1-102 and 1-030 and with the addition of 3 equivalents of NMM. ESI MS CaIc: 567.2; Found: 568.3 (M+H)+.
Example 399: methyl [(2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}-l,2,3,4-tetrahydroisoquinolin-6-yl)oxy]acetate from 1-102 and I- 038. ESI MS CaIc: 575.2; Found: 576.2 (M+Η)+.
Example 400: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-Λ7-methyl-l,2,3,4-tetrahydroisoquinoline-7-sulfonamide from 1-102 and N-methyl-l,2,3,4-tetrahydroisoquinoline-7-sulfonamide (WO 2006/67587 A2). ESI MS CaIc: 580.2; Found: 581.3 (M+Η)+.
Example 401: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-ΛyV-dimethyl-l,2,3,4-tetrahydroisoquinoline-7-sulfonamide from 1-102 and l,2,3,4-tetrahydro-isoquinoline-7-sulfonic acid dimethylamide (US 6,414,149). ESI MS CaIc: 594.2; Found: 595.3 (M+Η)+.
General Method F (Amide formation): A mixture of 1 equivalent of a carboxylic acid and 1 equivalent of (l-chloro-2-methyl-propenyl)-dimethyl-amine in CH2Cl2 is stirred for 2h when >1 equivalent of a secondary amine is added and the mixture is stirred for 2 - 24 h. The mixture is concentrated and purified by preparative HPLC, or is subjected to an aqueous workup (water, ΝaHCCb, and brine) before being purified by flash chromatography or preparative HPLC to provide Examples 402 - 405. Example 402: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(3,4-dihydroquinolin-l(2H)- ylcarbonyl)propyl]-lH-indole-4-sulfonamide is prepared from 1-102 and 1,2,3,4- tetrahydroquinoline. ESI MS CaIc: 487.2; Found: 488.3 (M+Η)+.
Example 403: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-iV- methyl- l,2,3,4-tetrahydroisoquinoline-7-carboxamide is prepared from 1-102 and 1-035. ESI MS CaIc: 544.2; Found: 545.3 (M+Η)+.
Example 404: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-Λ^,Λ^-dimethyl-l,2,3,4-tetrahydroisoquinoline-7-carboxamide is prepared from 1-102 and 1-036. ESI MS CaIc: 558.2; Found: 559.4 (M+Η)+.
Example 405: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[7-(morpholin-4-ylcarbonyl)-3,4- dihydroisoquinolin-2(lH)-yl]carbonyl}propyl]-lH-indole-4-sulfonamide is prepared from 1-102 and 1-037. ESI MS CaIc: 600.2; Found: 601.3 (M+Η)+.
Example 406: 4-amino-3,5-dichloro-Λ^-{l-[(4-methylcyclohexyl)carbonyl]-3-(2H-l,2,3- triazol-2-yl)propyl}benzenesulfonamide
Figure imgf000236_0001
A solution of 1.4 mL (10 mmol) of bromo-4-methylcyclohexane in 5 mL of THF is added slowly to 290 mg (12 mmol) of Mg turnings stirring in 5 mL of THF under N2 at a rate that maintains a gentle reflux. The mixture is cooled to rt to provide a ~ 1 M solution of 4- methylcyclohexanemagnesium bromide. To a solution of 110 mg (0.25 mmol) of 1-105 in 2 mL of THF is added 5 mL of IM 4-methylcyclohexanemagnesium bromide in THF (5.0 mmol). After stirring for 2.5 days, saturated aqueous NH4Cl is added. The mixture is extracted with EtOAc, and the extract is washed with water and brine, and then dried with MgSO4, filtered, and concentrated. Purification first by flash chromatography, and then by preparative HPLC provides 18 mg (16%) of Example 406 as a white solid. ESI MS. CaIc: 473.1; Found: 474.0 (M+H)+.
Example 407: 4-amino-3,5-dichloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methyl- cyclohexyOcarbonylJpropyllbenzenesulfonamide is prepared from 1-104 in the same manner as Example 406. ESI MS. CaIc: 496.1; Found: 497.1 (M+Η)+.
Example 408: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-({4-[(£7Z)-(methoxyimino)methyl] piperidin-l-yl}carbonyl)propyl]-lH-indole-4-sulfonamide
Figure imgf000237_0001
To a stirring solution of 0.020 mL (0.23 mmol) of oxalyl chloride in 1 mL of CΗ2CI2 at -78 °C is added 0.033 mL (0.46 mmol) of DMSO. After stirring for 30 min, a solution of 0.072 g (0.15 mmol) of Example 259 is added. After stirring for 2h at -78 9C, 0.11 mL (0.77 mmol) of Et3N is slowly added. The mixture is allowed to warm to rt as it is stirred overnight, and then water is added. The mixture is extracted twice with CH2Cl2, and the combined extracts are washed with brine, dried over MgSO4, filtered, and concentrated to provide the aldehyde as a dark solid. A solution of 29 mg (0.062 mmol) of this aldehyde in 1 mL of pyridine and 15 mg (0.19 mmol) of N-methoxylamine hydrochloride is stirred overnight, and then is concentrated. Purification of the residue by preparative HPLC provides 11 mg (36%) of Example 408 as a 4:1 mixture of EfZ isomers. ESI MS: CaIc: 496.2; Found: 497.2 (M+H)+.
Example 409: l-acetyl-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}-lH-indole-4-sulfonamide
Figure imgf000238_0001
Example 30 (30 mg, 0.066 mmol) is stirred with 6.9 μL (0.073 mmol) of acetic anhydride and 0.8 mg of DMAP in 2 mL of CH2Cl2 for 3h. An additional 0.04 mL of acetic anhydride and 1 mg of DMAP is added and the mixture is stirred overnight. The mixture is concentrated and purified by flash chromatography (1: 1 EtOAc/hexanes) to provide 25 mg (76%) of Example 409 as a white foam. ESI MS: CaIc: 495.2; Found: 496.2 (M+H)+.
Example 410: tert-buty\ 4-[({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}amino)sulfonyl]-lH-indole-l-carboxylate
Figure imgf000239_0001
To a stirring solution of 45 mg (0.10 mmol) of Example 30 in 1 mL of CH2CI2 is added a solution of 24 mg (0.11 mmol) of BoC2O and 2.4 mg (0.020 mmol) of DMAP in 1 mL of CH2Cl2. After stirring for Ih, the mixture is concentrated and purified by flash chromatography (2:1 hexanes/EtOAc) to provide 46 mg (84%) of Example 410 as a white foam. ESI MS: CaIc. 553.2, Found: 554.4 (M+H)+.
Example 411: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-Λ7-methyl-lH-indole-4-sulfonamide
Figure imgf000239_0002
A solution of 0.11 g (0.19 mmol) of Example 410, 40 mg (0.29 mmol) of K2CO3, and 24 μL (0.39 mmol) of MeI is stirred in 1 mL of DMF for Ih. EtOAc is added, and the mixture is washed twice with water and once with brine, dried over MgSO4, filtered, and concentrated. This residue is stirred in 1.3 mL of 25% TFA in CΗ2CI2 for 12h. The mixture is concentrated and purified by preparative HPLC to provide 74 mg (84%) of Example 411. ESI MS: CaIc. 467.2, Found: 468.4 (M+H)+. Example 412: lH-Indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(perhydro-l,4- diazepine- 1 -carbonyl) -propyl] -amide
Figure imgf000240_0001
A solution of 0.65 g (1.1 mmol) of Example 396 in 6 mL of 4 M HCl in 1,4-dioxane is stirred overnight, concentrated, and then is dissolved in 2 mL of 10% MeOΗ/CΗ2Cl2. Hydrochloric acid (2 mL of 4M in 1,4-dioxane) is added. The mixture is stirred overnight, and then is dissolved in 1 M NaHSO4 and extracted with EtOAc. The aqueous phase is basified with solid NaOH until the pH is 8. This mixture is extracted twice with EtOAc and the extracts are washed with brine, dried over Na2SO4, filtered, and concentrated to provide 0.46 g (86%) of Example 412. ESI MS: CaIc. 454,2; Found: 455.3 (M+H)+.
Example 413: 4-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,4-diazepane-l-carboxamide.
Figure imgf000240_0002
A mixture of 0.040 g (0.088 mmol) of Example 412 and 0.023 mL of trimethylsilylisocyanate (0.17 mmol) is stirred in 0.5 mL of MeCN overnight. The mixture is purified directly by preparative HPLC to provide 19 mg (42%) of Example 413 as a white foam. ESI MS: CaIc. 497.2; Found: 498.2 (M+H)+
Example 414: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-glycoloyl-l,4-diazepan-l- yl)carbonyl]propyl}-lH-indole-4-sulfonamide
Figure imgf000241_0001
A mixture of 0.050 g (0.11 mmol) of Example 412 and 0.024 mL (0.22 mmol) of acetoxyacetyl chloride is stirred with 0.17 g (0.34 mmol) of PS-NMM in 2 mL of TΗF. After 4h, 0.039 g (0.060 mmol) of PS-Isocyanate and 0.046 g (0.17 mmol) of PS-trisamine are added, and the mixture is agitated for 30 min. The solvent is filtered, and the resins are washed with CΗ2CI2 and EtOAc. The combined washes are concentrated, and the residue is taken up in 2 mL of 1.65 M HCl in MeOH and agitated overnight. The mixture is concentrated and purified by preparative HPLC to provide 38 mg (67%) of Example 414 as a white foam. ESI MS: CaIc. 512.2; Found: 513.2 (M+H)+
Example 415: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-propionyl-l,4-diazepan-l- yl)carbonyl] propyl}- lH-indole-4-sulfonamide
Figure imgf000242_0001
A mixture of 0.048 g (0.11 mmol) of Example 412 and 0.024 mL (0.21 mmol) of propionyl chloride is stirred with 0.15 g (0.31 mmol) of PS-NMM in 2 mL of THF. After 4h, 0.035 g (0.054 mmol) of PS-Isocyanate and 0.044 g (0.16 mmol) of PS-trisamine are added, and the mixture is agitated for 30 min. The solvent is filtered, and the resins are washed with CH2Cl2 and EtOAc. The filtrate is concentrated and purified by preparative HPLC to provide 27 mg (51%) of Example 415 as a white foam. ESI MS: CaIc. 510.2; Found: 511.2 (M+H)+
Example 416: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(methylsulfonyl)-l,4-diazepan-l- yl]carbonyl}propyl]-lH-indole-4-sulfonamide
Figure imgf000242_0002
A mixture of 0.050 g (0.11 mmol) of Example 412 and 0.017 mL (0.22 mmol) of methanesulfonyl chloride is stirred with 0.17 g (0.34 mmol) of PS-NMM in 2 mL of TΗF. After 4h, 0.039 g (0.060 mmol) of PS-Isocyanate and 0.046 g (0.17 mmol) of PS-trisamine are added, and the mixture is agitated for 30 min. The solvent is filtered, and the resins are washed with CH2Cl2 and EtOAc. The combined washes are concentrated and purified by preparative HPLC to provide 38 mg (65%) of Example 416 as a white foam. ESI MS: CaIc. 532.2; Found: 533.2 (M+H)+
Example 417: 2-chloro-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl] propyl}-4-(/H-tetrazol-5-yl)benzenesulfonamide
Figure imgf000243_0001
To a solution of lOOmg (0.21 mmol) of Example 69 in 1.0 mL of NMP is added 41 mg (0.63 mmol) of NaN3 and 87 mg (0.63 mmol) of Et3N-HCl. The reaction is stirred at 140 0C in a pressure tube for 15 min. The mixture is cooled and diluted with 50 mL of water. The pH is brought to 4 with addition of IN HCl. The solution is extracted with EtOAc (3x10OmL), and the combined extracts washed with brine (5OmL), dried over Na2SO4, filtered, and concentrated. Preparative HPLC provides 52 mg (48%) of Example 417 as a white powder. ESI MS: CaIc. 516.2; Found: 517.5 (M+H)+.
Example 418: 2-chloro-Λ^-{3-(5-cyano-/H-pyrazol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl] propyl}-6-methylbenzenesulfonamide
Figure imgf000244_0001
Example 138 (38 mg, 0.073 mmol) is dissolved in 1 mL of DMA and 3 mg (0.003 mmol) of Pd2(dba)3, 3 mg ( 0.006 mmol) of dppf, 8.6 mg (0.073 mmol) Of Zn(CN)2, and 1.2 mg (0.018 mmol) of Zn powder are added. The mixture is heated in the microwave for 30 min at 120 9C. The reaction mixture is cooled and filtered, and then concentrated and purified by preparative HPLC to provide 11 mg (32%) of Example 418 as a colorless oil. ESI MS: CaIc. 463.1 ; Found: 464.3 (M+H)+.
Example 419: 4-amino-3,5-dichloro-Λ^-{3-(2-chloro-lH-pyrrol-l-yl)-l-[(4- methylpiperidin-l-yl)carbonyl]propyl}benzenesulfonamide
Figure imgf000244_0002
To a solution of 57 mg (0.12 mmol) of Example 235 in 1.0 mL of DMF is added 16 mg (0.12 mmol) of NCS and the mixture is stirred for 2 days. Preparative ΗPLC provides 14 mg (23%) of Example 419. ESI MS: CaIc: 506.1; Found: 507.0 (M+Η)+. Example 420: 3-bromo-Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl] propyl}-/H-indole-4-sulfonamide
Figure imgf000245_0001
To 110 mg (0.24 mmol) of Example 30 in 1 mL of DMF is added 42 mg (0.24 mmol) of NBS. After stirring for 24 h, the mixture is purified directly by preparative ΗPLC to provide 17 mg (14%) of Example 420 as a white solid. ESI MS: CaIc: 531.1 ; Found: 532.5 (M+Η)+.
Example 421: 3-cyano-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-lH-indole-4-sulfonamide
Figure imgf000245_0002
To compound Example 30 (0.18 g, 0.41 mmol) in 1 mL of MeCN at 0 °C is added 0.035 mL (0.41 mmol) of chlorosulphonyl isocyanate. After stirring for 30 min, 0.037 mL (0.49 mmol) of DMF is added. Two hours later, the mixture is directly purified first by preparative ΗPLC, and then by flash chromatography to provide 110 mg (55%) of Example 421. ESI MS: CaIc: 478.2; Found: 479.5 (M+Η)+. Example 422 : 4- [({3-(2-cyano-lH- pyrrol- 1-yl)- 1- [(4-methylpiperidin- l-yl)carbonyl] propyl}amino)sulfonyl]-lH-indole-3-carboxamide
Figure imgf000246_0001
To compound Example 30 (0.030 g, 0.066 mmol) in 1 mL of MeCN at 0 9C is added 0.006 mL (0.07 mmol) of chlorosulfonyl isocyanate. Two hours later, the mixture is directly purified by preparative HPLC to provide 5.2 mg (16 %) of Example 422. ESI MS: CaIc: 496.2; Found: 497.4 (M+H)+.
Example 423: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-oxoindoline-4-sulfonamide and Example 424: Λ7-{3-(3-bromo-2-cyano-lH- pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}-2-oxoindoline-4-sulfonamide
Figure imgf000246_0002
To a solution of 0.055 g (0.12 mmol) of Example 30 in 1.0 mL of f-butanol is added 0.13 g (0.36 mmol) pyridine bromide perbromide. After stirring for 2h, the solution is concentrated and 1.0 mL of glacial acetic acid and 0.079 g (1.2 mmol) of Zn powder is added. After stirring for 30 min., EtOAc is added, and the mixture is washed with saturated NaHCO3, water, and brine, and then is dried over MgSO4, filtered, and concentrated. The residue is purified by preparative HPLC to provide 1.3 mg (2.3%) of Example 423 and 15 mg (23%) of Example 424. Example 423: ESI MS: CaIc: 469.2; Found: 470.3; Example 424: ESI MS:
CaIc: 547.1; Found: 548.2.
Example 425: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3-formyl-/H-indole-4-sulfonamide
Figure imgf000247_0001
To 1.5 mL of DMF at 0 0C is added 0.033 mL (0.36 mmol) of POCl3. After stirring for 20 min, 0.15 g (0.33 mmol) of Example 30 in 0.5 mL of DMF is added dropwise. The mixture is stirred at 35 0C overnight. Crushed ice is added, followed by 1.6 mL (1.6 mmol) of IN NaOH, and the resulting mixture is stirred for 5h. The mixture is extracted twice with EtOAc, and the extracts are washed with brine, dried over MgSO4, filtered, and concentrated. Flash chromatography provides 71 mg (45%) of Example 425. ESI MS: CaIc: 481.2, Found: 482.4 (M+Η)+.
Example 426: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-3-(hydroxymethyl)-/H-indole-4-sulfonamide
Figure imgf000248_0001
To a stirring solution of 0.030 g (0.062 mmol) of Example 425 in 1.0 mL of MeOH at 0 0C is added 4.7 mg (0.13 mmol) of NaBH4. After stirring for 2h, the mixture is diluted with MeCN-H2O, filtered, and purified by preparative HPLC to provide 16 mg (53%) of Example 426 as a red solid. ESI MS: CaIc: 483.2, Found: 466.2 (M-OH)".
General Method G (Deprotection of JV-BOC indoles): An N-Boc-indole is stirred in 20 - 50% TFA in CH2Cl2 for 3 - 12h, and then is concentrated. If necessary, purification by flash chromatography or preparative HPLC provides Examples 427 - 434.
Example 427: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}- lH-indole-7-sulfonamide from Example 181. ESI MS: CaIc. 453,2; Found: 454.7 (M+Η)+.
Example 428: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-2-methyl-lH-indole-3-sulfonamide from Example 191. ESI MS: CaIc. 467,2; Found: 468.2 (M+Η)+.
Example 429: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-5-fluoro-lH-indole-4-sulfonamide from Example 194. ESI MS: CaIc. 471.2; Found: 472.7 (M+Η)+. Example 430: Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-5-fluoro-lH-indole-6-sulfonamide from Example 195. ESI MS: CaIc. 471.2; Found: 472.7 (M+Η)+.
Example 431: 5-chloro-N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}-lH-indole-4-sulfonamide from Example 201. ESI MS: CaIc: 487.1, Found: 488.7 (M+H)+.
Example 432: 5-chloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l- yl)carbonyl]propyl}-lH-indole-6-sulfonamide from Example 202. ESI MS: CaIc: 487.1, Found: 488.7 (M+Η)+.
Example 433: Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-(5,6-dihydro[l,2,4]triazolo[4,3- aJpyrazin-TCSH^ylcarbonyOpropylJ-S-chloro-lH-indole^-sulfonamide from Example 204. ESI MS: ESI MS: CaIc: 512.1, Found: 513.7 (M+Η)+.
Example 434: 5-chloro-lH-indole-6-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(5,6- dihydro-8H-[l,2,4]triazolo[4,3-α]pyrazine-7-carbonyl)-propyl]-amide from Example 205. ESI MS: CaIc: 512.1, Found: 513.7 (M+Η)+.
Example 435: 4-({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]- propyljsulfamoyl)- lH-indole-7-carboxylic acid
Figure imgf000250_0001
A mixture of 9.0 mg (0.014 mmol) of Example 206, 0.085 mL (0.085 mmol) of IM TBAF in THF, 1.0 mL of DMF, and 0.1 mL of ethylenediamine is stirred at 80 9C for 48 h. Direct purification by preparative HPLC provided 3.2 mg of Example 435. ESI MS: 497.2; Found: 498.2 (M+H)+.
Example 436: ethyl 3-{4-[({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}amino)sulfonyl]-lH-indol-3-yl}propanoate
Figure imgf000250_0002
To a stirring mixture of 61 mg (1.5 mmol) of 60% NaH in mineral oil in 5 mL of THF at 0 0C is slowly added a solution of 0.28 mL (1.4 mmol) of triethyl phosphonoacetate in 5 mL of THF. The mixture is allowed to warm to rt as it is stirred for 2h. A solution of 0.23 g (0.48 mmol) of Example 425 in 2 mL of THF is added, and the resulting solution is stirred overnight at 60 9C. Aqueous NH4Cl is added, and the mixture is extracted with EtOAc. The extract is washed with brine, dried over MgSO4, filtered, and concentrated, and then the resulting residue is purified by flash chromatography (50-100% EtOAc in hexanes) to provide 63 mg (23%) of the enoate product. This material, 20 mg of Pd/C, and 25 mL of MeOH is stirred under 50 psi of H2 for 3h. After filtration through diatomaceous earth, the filtrate is concentrated. The resulting residue is purified by flash chromatography (50% EtOAc in hexanes) to provide 23 mg (38%) of Example 436 as a colorless oil. ESI MS: CaIc: 553.2; Found: 554. ESI MS: CaIc: 553.2; Found: 554.5 (M+H)+.
Example 437: Λ^-{3-(2-cyano-/H-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}-5-methyl-2,3-dihydro-l-benzofuran-7-sulfonamide
Figure imgf000251_0001
To 0.025 g (0.047 mmol) of Example 161 in 1 mL of DMF is added 2.5 mg (3 mg, 0.003 mmol) of Pd2(dba)3, 2 mg (0.006 mmol) of P(o-tolyl)3, and 0.013 mL (0.094 mmol) of PhMe3Sn. The mixture is stirred at 80 0C for 3 h, and then is filtered. The filtrate is concentrated and the residue is purified by preparative ΗPLC to provide 32 mg (7%) as a beige solid. ESI MS: CaIc. 470.2, Found: 471.5 (M+Η)+.
General Method H (Indole chlorination): Indole is stirred in DMF at rt along with ≥l equivalent of NCS for 12 to 72 h. The mixture is diluted with EtOAc and washed with aqueous NaSO3, water, and brine, then dried with Na2SO4, filtered, and concentrated. The resulting residue is purified by preparative HPLC to provide Examples 438 - 443. Example 438 : 3-chloro-Λ7-{3-(2-cyano- IH- pyrrol- 1-yl)- 1- [(4-methylpiperidin- 1-yl) carbonyl]propyl}-lH-indole-6-sulfonamide is prepared from Example 31. ESI
MS: CaIc: 488.1; Found: 489.2 (M+Η)+.
Example 439: 3-chloro-Λ^-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-lH-indole-4-sulfonamide is prepared from Example 30. ESI
MS: CaIc: 487.1; Found: 488.5 (M+Η)+.
Example 440: 3-chloro-Λ^-{3-(5-cyano-lH-pyrazol-l-yl)-l-[(4-methylpiperidin-l-yl) carbonyl]propyl}-lH-indole-4-sulfonamide is prepared from Example 37. ESI
MS: CaIc: 488.1; Found: 489.5 (M+Η)+.
Example 441: methyl l-[2-{[(3-chloro-lH-indol-4-yl)sulfonyl]amino}-4-(2-cyano-lH- pyrrol-l-yl)butanoyl]piperidine-4-carboxylate is prepared from Example 287. ESI
MS: CaIc: 531.1; Found: 532.4 (M+Η)+.
Example 442: 3-chloro-Λ^-[3-(2-cyano-lH-pyrrol-l-yl)-l-{[4-(hydroxymethyl) piperidin- l-yl]carbonyl}propyl]-lH-indole-4-sulfonamide is prepared from Example 259.
ESI MS: CaIc: 503.1; Found: 504.4 (M+Η)+.
Example 443: 3,5-dichloro-lH-indole-4-sulfonic acid [3-(2-cyano-pyrrol-l-yl)-l-(4- methyl-piperidine-l-carbonyl)-propyl]-amide is prepared from Example 431. ESI
MS: CaIc: 521.1; Found: 522.7 (M+Η)+. General Method I (Saponification): To an ester in 1,4-dioxane is added 1 M NaOH (4 - 8 equiv.). After stirring for 4 - 12 h, the mixture is concentrated and dissolved in water, and then aq. HCl is added to bring the pH to between 1 and 3. Either the resulting precipitate is filtered and washed with water, then dried to provide the product, or the mixture is extracted with EtOAc, and the extracts are washed with brine, dried over Na2SO4, filtered, and concentrated to provide Examples 444 - 455.
Example 444: (l-{4-(2-cyano-/H-pyrrol-l-yl)-2-[(/H-indol-4-ylsulfonyl)amino] butanoyl}piperidin-3-yl)acetic acid from Example 306. ESI MS: CaIc: 497.2; Found: 498.1 (M+Η)+.
Example 445: (2£)-3-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl) amino]butanoyl}piperidin-3-yl)prop-2-enoic acid from Example 322. ESI MS:
CaIc: 509.2; Found: 510.2 (M+Η)+.
Example 446: 3-(l-{4-(2-cyano-/H-pyrrol-l-yl)-2-[(/H-indol-4-ylsulfonyl)amino] butanoyl}piperidin-3-yl)propanoic acid from Example 326. ESI MS: CaIc: 511.2;
Found: 512.1 (M+Η)+. Example 447: 3-(l-{4-(2-cyano-/H-pyrrol-l-yl)-2-[(/H-indol-4-ylsulfonyl)amino] butanoyl}piperidin-4-yl)propanoic acid from Example 327. ESI MS: CaIc: 511.1;
Found: 512.1 (M+Η)+.
Example 448: 4-(l-{4-(2-cyano-/H-pyrrol-l-yl)-2-[(/H-indol-4-ylsulfonyl)amino] butanoyl}piperidin-4-yl)butanoic acid from Example 334. ESI MS: CaIc: 525.2; Found: 526.1 (M+Η)+. Example 449: 4-(l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}piperidin-3-yl)butanoic acid from Example 335. ESI MS: CaIc: 525.2; Found: 526.1 (M+Η)+.
Example 450: 3-{4-[({3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl] propyl}amino)sulfonyl]-lH-indol-3-yl}propanoic acid from Example 436. ESI
MS: CaIc: 525.2; Found: 526.2 (M+Η)+.
Example 451: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,2,3,4-tetrahydroisoquinoline-6-carboxylic acid from Example 340.
ESI MS: CaIc: 531.2; Found: 532.2 (M+Η)+.
Example 452: 2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,2,3,4-tetrahydroisoquinoline-7-carboxylic acid from Example 341.
ESI MS: CaIc: 531.2; Found: 532.2 (M+Η)+.
Example 453: 3-[(cis)-l-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-4-methylpiperidin-3-yl]propanoic acid from Example 347. ESI MS: CaIc: 525.2; Found: 526.3 (M+Η)+.
Example 454: [(2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}-l,2,3,4-tetrahydroisoquinolin-6-yl)oxy]acetic acid from Example 399.
ESI MS: CaIc: 561.2; Found: 562.2 (M+Η)+. Example 455: 2-[(2-{4-(2-cyano-lH-pyrrol-l-yl)-2-[(lH-indol-4-ylsulfonyl)amino] butanoyl}- l,2,3,4-tetrahydroisoquinolin-7-yl)oxy] -2-methylpropanoic acid from Example 361. ESI MS: CaIc: 589.2; Found: 590.3 (M+Η)+.
Procedures for Identification of CCRlO Antagonists
CCRlO FLIPR Assay
Preferred compounds have an IC50 of 500 nM or lower in this assay.
To a 1 liter bottle of Hams F12 (Mediatech #10-080-CM ) add 100 mL Fetal Bovine Serum (Mediatech #35-015-CV ), 10 mL geneticin (Invitrogen #10131-027), and 2 mL Zeocin (Invitrogen #R250-05).
CHO-Kl hCCRlO cells (Euroscreen cat # ES-143-A) are diluted in media to a final concentration of 2.8 X 105 cells/mL and 25 μL of this suspension are added to each well of a BD384 well TC treated assay plate (VWR #62406-490). This will yield approximately 7,000 cells/well. The plate is incubated at 37°C/5% CO2 overnight.
The EC50 and EC70 should be calculated each time the assay is performed. CTACK/CCL27 (R&D Systems # 376-CT; 30 μM stock) is diluted to a working concentration of 10 μM (2.5 μM final) in peptide buffer ( HBSS/lmM CaCl/lmM MgSO4 /0.1% BSA) . This is serially diluted 1 :3 in the same buffer for a total of 11 concentrations of peptide. The assay below is run and the EC50 of the CCL27 is calculated. Test compounds are assayed at the EC70. Cell plates are removed from the incubator, inverted to "flick" out media and tapped dry on a paper towel. 25 μL Ix FLUO-4 dye/2 mM probenicid (Molecular probes Fluo-4 kit # F36206) are added to each well. The plates are then incubated 30 minutes at 37°C/5% CO2, then removed and incubated 30 additional minutes at room temperature. 5 μL diluted (see below) test compound (final concentration based on 30 μL) are added to appropriate wells. The wells are mixed and incubated at room temperature for 15 minutes. The plates are then placed on FLIPR and 10 μL CCL27 (30 μM stock diluted to appropriate 4x of final concentration at EC70) from a Greiner 384 well polypropylene plate are transferred.
Plate reader data are analyzed using ActivityBase software (ID Business Solutions, Ltd). The RFU signals from the plate reader are converted to percent of control (POC) values using the formula:
POC = 100*(Signal -BCTRL) ÷ (PCTRL-BCTRL)
Where Signal is the test well signal, BCTRL is the average of background (negative control) well signals on the plate and PCTRL is the average of positive control well signals on the plate.
For the concentration responsive compounds, POC as a function of test compound concentration are fitted to a 4-parameter logistic equation of the form:
Y = A + (B-A)/ [l+(x/C)D] Where A, B, C, and D are fitted parameters (parameter B is fixed at zero POC), and x and y are the independent and dependent variables, respectively. The IC50 (50% inhibitory concentration) is determined as the inflection point parameter, C.
Ix Assay Buffer: Ix HBSS (1Ox, Invitrogen #14185-027), 10 mM HEPES pH 7.4, 0.35 g/L sodium bicarbonate, 1 mM CaCl2, 1 mM MgSO4
Chemotaxis Assay
Test compounds are evaluated for their ability to inhibit chemotaxis of Baf/3 cells expressing human CCRlO (hereinafter Baf/3-hCCRlO cells) in response to CCL27. Preferred compounds have IC50 < 1 μM in this assay.
Test compounds are diluted (2x the final concentration) in CTX media (RPMI 1640 (Gibco- BRL #11875-093) supplemented with 0.1 % BSA (Sigma #A3803)). Control solutions contain 1% DMSO in CTX media. Baf/3-hCCR10 cells are re-suspended in CTX media to a concentration of 4xlO6 cells/mL. In a 96 well plate, 100 μL the Baf/3-hCCR10 cell suspension is combined with 100 μL of the test compound solution and the plate is then incubated for 15 minutes at room temperature.
150 μL of a solution of the chemoattractant (2x the EC70 for CCL27) in CTX media is added to appropriate wells of a 96- well chemotaxis chamber (Neuro Probe Cat. #:116-5, 5 μm pore size, 5.7mm diameter size, 300 μL, 96 well plate). CTX media without chemoattractant is added to control wells. 152 μL of 2x compound solution in CTX media is added to appropriate wells. The chamber is assembled according to manufacturer's instructions using the 5 micron pore size PVP- free polycarbonate filter. Care should be taken to avoid bubbles as they will cause variation.
80 μL of the cells plus compound incubation mixture is added to upper wells of the chamber. Care is taken to avoid forming bubbles at the level of the filter. The chamber is then incubated at 37 0C for 3 hours.
The chamber is then disassembled and the filter is removed. 150 μL of media is gently removed from each well of the chemotaxis chamber. The remaining 150 μL is then mixed and 100 μL of the resulting cell suspension is transferred into a 96 well Costar 3917assay plate (Corning incorporated, cat # 3917).
The cells are measured using a CyQU ANT® NF Cell Proliferation Assay (Invitrogen, cat # C35006). 11 mL of Ix HBSS buffer is prepared by diluting 2.2 mL of 5x HBSS buffer (Component C) with 8.8 mL of deionized water. Ix dye binding solution is prepared by adding 22 microL of CyQU ANT® NF dye reagent (Component A) and 22 microL of Component C to 11 mL of Ix HBSS buffer. 100 microL of Ix dye binding solution is dispensed into wells of the 96 well Costar plate containing the cell suspensions. The plate is covered and incubated at 37°C for 60 minutes. Fluorescence measurement is quantitated using a multilabel plate reader (Wallac Victor2).
Methods of Therapeutic Use
In accordance with the invention, there are provided novel methods of using the compounds of the present invention. The compounds disclosed herein effectively block the interaction of CCRlO with its ligand CCL 27. The inhibition of this interaction is an attractive means for preventing and treating a variety of diseases or conditions associated with entry and activation of T-cells into the skin or other tissues where CCRlO is found to be expressed and associated with inflammatory conditions, such as lung tissue. Thus, the compounds of the present invention are useful for the treatment of diseases and conditions including psoriasis, contact sensitivity, dermatitis, systemic sclerosis, cutaneous systemic lupus erythematosus, and allergic asthma. The compounds of the invention will also be useful for treatment of melanomas that express CCRlO.
These disorders have been well characterized in man, but also exist with a similar etiology in other mammals, and can be treated by pharmaceutical compositions of the present invention.
For therapeutic use, the compounds may be administered in a therapeutically effective amount in any conventional dosage form in any conventional manner. Routes of administration include, but are not limited to, intravenously, intramuscularly, subcutaneously, intrasynovially, by infusion, sublingually, transdermally, orally, topically or by inhalation, tablet, capsule, caplet, liquid, solution, suspension, emulsion, lozenges, syrup, reconstitutable powder, granule, suppository and transdermal patch. Methods for preparing such dosage forms are known (see, for example, H.C. Ansel and N.G. Popovish, Pharmaceutical Dosage Forms and Drug Delivery Systems, 5th ed., Lea and Febiger (1990)). A therapeutically effective amount can be determined by a skilled artisan based upon such factors as weight, metabolism, and severity of the affliction etc. Preferably the active compound is dosed at about 1 mg to about 500 mg per kilogram of body weight on a daily basis. More preferably the active compound is dosed at about 1 mg to about 100 mg per kilogram of body weight on a daily basis. The compounds may be administered alone or in combination with adjuvants that enhance the stability of the inhibitors, facilitate administration of pharmaceutic compositions containing them in certain embodiments, provide increased dissolution or dispersion, increase inhibitory activity, provide adjunct therapy, and the like. Advantageously, such combinations may utilize lower dosages of the active ingredient, thus reducing possible toxicity and adverse side effects. Pharmaceutically acceptable carriers and adjuvants for use with compounds according to the present invention include, for example, ion exchangers, alumina, aluminum stearate, lecithin, serum proteins, buffer substances, water, salts or electrolytes and cellulose -based substances. This is not a complete list possible pharmaceutically acceptable carriers and adjuvants, and one of ordinary skilled in the art would know other possibilities, which are replete in the art.

Claims

CLAIMSWe Claim:
1. A compound formula (I):
Figure imgf000261_0001
wherein:
Ar is phenyl, naphthyl or heteroaryl. selected from indolyl, pyridyl, thienyl, pyrazolyl, oxazolyl, indazolyl, benzimidazolyl, isoquinolinyl, lH-pyrrolo[2,3-b]pyridinyl, benzothienyl, benzofuranyl, 2,1,3-benzothiadiazolyl and 6H-imidazo[2,l-b]thiazolyl, wherein said phenyl naphthyl or heteroaryl is optionally substituted with one to four groups selected from Ci_
6alkyl, Ci_6alkoxy, phenyl, heteroaryl, phenyloxy, halogen, -NH2, -NHC(O)NH2, -NHC(O)Ci_ galkyl, -NO2, -CF3, -OCF3, -CN, -C(O)C1-6alkyl, -(CH2)0-2CO2Ci_6alkyl, -(CH2)0-2CO2H, 5- tetrazolyl, -CHO, -C(O)NH2, -C(O)NH(d_6alkyl) and -C(O)N(d_6alkyl)2; or if Ar is phenyl, two adjacent groups together with the phenyl they are bonded to may form a
2,3-dihydrobenzofuranyl, l,3-dihydroindol-2-one, or 2-acetyl-3,4-dihydro-lH-isoquinolinyl group;
Het is a heteroaryl group selected from:
Figure imgf000262_0001
Figure imgf000262_0002
and
and is optionally substituted with one to two groups independently selected from -CN, -NO2, halogen, -Ci_6alkyl, -C(O)NH2 and CO2Me;
R1 and R2 are independently selected from C^alkyl, arylC^alkyl, phenyl, naphthyl and C3_ gcycloalkyl, wherein said arylCi_2alkyl is optionally substituted with one to two groups selected from halogen, Ci_6alkoxy, Ci_6alkyl, -CF3, imidazolyl, pyridyl, pyrimidinyl, pyrazolyl, 5-methyloxadiazolyl, morpholinyl, piperidinyl and N-methyl-1,2,3,4- tetrahydroisoquinolinyl; or
R1 and R2, together with the N they are bonded to form a heterocycle selected from piperidine, morpholine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, azepane, 6-aza-spiro[2.5]octane, 2,3,4,5-tetrahydro-lH-benzo[b]azepine, [l,4]-diazepane, [1,4]- oxazepane, thiomorpholine, thiomorpholine, thiomorpholine 1,1 -dioxide, 4,5,6,7- tetrahydrothieno[3,2-c]pyridine, , 5,6,7,8-tetrahydro-[l,2,4]triazolo[4,3-a]pyrazine, 5,6,7,8- tetrahydro-imidazo[l,5-α]pyrazine, 4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine, 1,2,3,6- tetrahydropyridine and octahydropyrido[l,2-a]pyrazine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_6alkyl, Ci_6alkenyl, phenyl, benzyl, hydroxyCi_6alkyl, -OH, -CF3, -CN, halogen, -NO2, -NH2, oxo, 1,3-dioxolane, -CH=NOCH3, -SO2NH2, -SO2N(Ci_6alkyl)2, -SO3H, -SO2(Ci_6alkyl)2, -C(O)N(Ci_6alkyl)2, -C(O)NHCi_6alkyl, -(CH2)0-2C(O)NH2, -(CH2)0^CO2H, -(CH2)o-4C02Ci_6alkyl, =C-CO2Ci_ galkyl, -CH=CH-CO2H, -CH=CH-CO2Ci_6alkyl, -OCH2CO2H, -OCH2CO2Ci_6alkyl,
-OC(CHs)2CO2H, -OC(CH3)2CO2Ci_6alkyl, -C(O)CH2CO2H, -C(O)CH2CO2Ci_6alkyl,
-C(O)d_6alkyl, -C(O)d_4alkyl(OH), -CH2Od_6alkyl, -(CH2)0_2NHC(O)C1_6alkyl,
-C(O)morpholinyl, thiazole, 3-methyl-l,2,4-oxadiazolyl, pyrimidine and 2-[l,2,4]oxadiazol-
3-ylpyrazine; and
R4 is hydrogen or Ci_6alkyl; or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1, wherein:
Ar is phenyl, naphthyl or heteroaryl selected from indolyl, pyridyl, thienyl, pyrazolyl, indazolyl, isoquinolinyl, benzothienyl, benzofuranyl, and 6H-imidazo[2,l-b]thiazolyl, wherein said phenyl naphthyl or heteroaryl is optionally substituted with one to four groups selected from CH3, -CH2CH3, -OCH3, Cl, Br, F, -NH2, C(O)CH3, NHC(O)CH3, -CF3, -OCF3,
-CN and -CO2CH3; or if Ar is phenyl, two adjacent groups together with the phenyl they are bonded to may form a
2,3-dihydrobenzofuranyl or oxindolyl group;
Het is a heteroaryl group selected from
Figure imgf000263_0001
wherein R3 is selected from -CN, -NO2, Cl, Br, -C(O)NH2 and CO2Me;
R1 is CH3 and R2 is benzyl, wherein said benzyl is optionally substituted with one to two groups selected from halogen, Ci_6alkoxy, Ci-6alkyl, -CF3, imidazolyl, pyridyl, pyrimidinyl, pyrazolyl, 5-methyloxadiazolyl, morpholinyl, piperidinyl and N-methyl-1, 2,3,4- tetrahydroisoquinolinyl; or
R1 and R2, together with the N they are bonded to form a heterocycle selected from piperidine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, 6-aza- spiro[2.5]octane, azepane, [l,4]-diazepane and [l,4]-oxazepane, 4,5,6,7-tetrahydrothieno[3,2- c]pyridine, 5,6,7,8-tetrahydro-imidazo[l,5-α]pyrazine, 1,2,3,6-tetrahydropyridine, 5,6,7,8- tetrahydro-[l,2,4]triazolo[4,3-a]pyrazine, 2,3,4,5-tetrahydro-lH-benzo[b]azepine and 1,2,3,6- tetrahydropyridine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_6alkyl, Ci_6alkenyl, phenyl, benzyl, -CFj, -CN, Cl, Br, F, -NO2, oxo, -CH=NOCH3, SO2NH2, -SO2N(CH3)2, -SO3H, -SO2(CH3), -C(O)N(CH3)2, -C(O)NHCH3, -(CH2V2C(O)NH2, -(CH2)o-4C02H, -(CH2)0^CO2Ci_2alkyl, -(CH2)0-4OH, -CH=CH-CO2H, -CH=CH-CO2Ci_2alkyl, =C-CO2Ci_6alkyl, -OCH2CO2H, -OCH2CO2Ci_2alkyl, -OC(CH3)2CO2H, -OC(CH3)2CO2C1_2alkyl, -C(O)CH2CO2H, -C(O)CH2CO2C1_2alkyl, -C(O)CH3, -C(0)Ci_4alkyl(0H), -CH2OCH3, -(CH2)0-2NHC(O)CH3, -C(O)morpholinyl, thiazole, 3-methyl-l,2,4-oxadiazolyl, pyrimidine and 2-[l,2,4]oxadiazol-3-ylpyrazine; and R4 is hydrogen; or a pharmaceutically acceptable salt thereof.
3. The compound of claim 1, wherein:
Ar is phenyl, indolyl, thienyl or indazolyl, wherein each is optionally substituted with one to three groups selected from CH3, -CH2CH3, -OCH3, Cl, Br, F, -NH2, and -CF3;
Het is a heteroaryl group selected from
Figure imgf000265_0001
wherein R3 is selected from -CN, -NO2, Cl, Br, -C(O)NH2 and CO2Me;
R1 and R2, together with the N they are bonded to, form a heterocycle selected from piperidine, tetrahydroisoquinoline, decahydroisoquinoline, piperazine, 6-aza- spiro[2.5]octane, azepane, [l,4]-diazepane and [l,4]-oxazepane, 1,2,3,6-tetrahydrpyridine and 4,5,6,7-tetrahydrothieno[3,2-c]pyridine, wherein said heterocycle is optionally substituted by one to two groups selected from Ci_6alkyl, (CH2)o-2OH, -CF3, -CN, Cl, Br, F,
-(CH2)(MCO2H, -(CH2)o-4C02Ci_6alkyl, -C(O)N(CH3)2, -C(O)NHCH3, -C(O)NH2, -C(O)CH3,
-CH=CH-CO2H, -OC(CH3)2CO2H, -OC(CH3)2CO2H and -C(O)CH2CO2H; and
R4 is hydrogen; or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition comprising the compound of claim 1, or a pharmaceutically acceptable salt thereof.
5. A method of using the compound of claim 1, or a pharmaceutically acceptable salt thereo, to treat a disorder that is mediated or sustained through the activity of CCRlO.
6. The method of claim 5, wherein the disorder is inflammatory skin diseases, allergic asthma or melanoma.
7. A compound selected from the group consisting of:
N-{3-(2-cyano-lH-pyrrol-l-yl)-l-[(4-methylpiperidin-l-yl)carbonyl]propyl}thiophene-3- sulfonamide;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2- methylbenzenesulfonamide;N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}-3-methylbenzenesulfonamide;
N-{3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl}-4- methylbenzenesulfonamide;
N- { 1 - [(4-methylpiperidin- 1 -yl)carbonyl] -3-( 1 H-pyrazol- 1 -yl)propyl } - 1 H-indole-4- sulfonamide;
N- { 3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl} -2,4- dimethylbenzenesulf onamide ;
N- { 3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl} -2,5- dimethylbenzenesulf onamide ;
N- { 3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl}-3, 5- dimethylbenzenesulf onamide ;
N- { 3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- 1 -yl)carbonyl]propyl}-2- methoxybenzenesulf onamide ;
N- { 3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- 1 -yl)carbonyl]propyl}-3- methoxybenzenesulf onamide ;
N- { 3-(2-cyano-lH-pyrrol-l-yl)-l -[(4-methylpiperidin- l-yl)carbonyl]propyl}-4- methoxybenzenesulf onamide ;
N- [ 1 - { [4-(hydroxymethyl)piperidin- 1 -yl] carbonyl } -3 -( 1 H-pyrazol- 1 -yl)propyl] - 1 H-indole-4- sulf onamide; N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 ,3,5-trimethyl-
1 H-pyrazole-4- sulfonamide ;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -4-fluoro-2- methylbenzenesulf onamide ;
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide;
3 -chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide;
4-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}benzenesulfonamide;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2, 5- dimethylthiophene- 3 - sulfonamide ;
2-chloro-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 - yl)carbonyl]propyl}pyridine-3-sulfonamide;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-3 - sulfonamide;
2-cyano-N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -5 - methylbenzenesulf onamide ;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulf onamide;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-6- sulf onamide;
N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 -benzofuran-7- sulf onamide; N- { 3-(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - lH-indazole-4- sulfonamide;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indazole-6- sulfonamide;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-5 - sulfonamide;
N- { 3 -(3-cyano- 1 H-pyrazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide;
N- { 3 -(5-cyano- 1 H-pyrazol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } - 1 H-indole-4- sulfonamide;
N- { 3 -(2-cyano- 1 H-pyrrol- 1 -yl)- 1 - [(4-methylpiperidin- 1 -yl)carbonyl]propyl } -2,4,6- trimethylbenzenesulfonamide; and a tautomer thereof or a pharmaceutically acceptable salt thereof.
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