WO2009109769A3 - Screening for non-genotoxic carcinogens - Google Patents

Screening for non-genotoxic carcinogens Download PDF

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Publication number
WO2009109769A3
WO2009109769A3 PCT/GB2009/000642 GB2009000642W WO2009109769A3 WO 2009109769 A3 WO2009109769 A3 WO 2009109769A3 GB 2009000642 W GB2009000642 W GB 2009000642W WO 2009109769 A3 WO2009109769 A3 WO 2009109769A3
Authority
WO
WIPO (PCT)
Prior art keywords
screening
relates
genotoxic carcinogens
animal
genotoxic
Prior art date
Application number
PCT/GB2009/000642
Other languages
French (fr)
Other versions
WO2009109769A2 (en
Inventor
Charles Roland Wolf
Clifford Roy Elcombe
Original Assignee
Iti Scotland Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iti Scotland Limited filed Critical Iti Scotland Limited
Priority to JP2010549194A priority Critical patent/JP2011512834A/en
Priority to CA2717705A priority patent/CA2717705A1/en
Priority to EP09717169A priority patent/EP2268135A2/en
Priority to US12/920,717 priority patent/US20110119780A1/en
Publication of WO2009109769A2 publication Critical patent/WO2009109769A2/en
Publication of WO2009109769A3 publication Critical patent/WO2009109769A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70567—Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention relates to a method for screening for the effects of non-genotoxic carcinogens in an animal model. The invention also relates to animal models that are suitable for use in such a method, and cell lines derived from these animals for in vitro screening purposes. More specifically, the invention relates to a transgenic rodent animal which has been humanised for the nuclear transcription factors CAR, PXR and PPARα, and in which the endogenous equivalent genes have been rendered inoperable.
PCT/GB2009/000642 2008-03-07 2009-03-09 Screening for non-genotoxic carcinogens WO2009109769A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2010549194A JP2011512834A (en) 2008-03-07 2009-03-09 Screening for non-genotoxic carcinogens
CA2717705A CA2717705A1 (en) 2008-03-07 2009-03-09 Screening for non-genotoxic carcinogens
EP09717169A EP2268135A2 (en) 2008-03-07 2009-03-09 Screening for non-genotoxic carcinogens
US12/920,717 US20110119780A1 (en) 2008-03-07 2009-03-09 Screening for non-genotoxic carcinogens

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0804310.1 2008-03-07
GBGB0804310.1A GB0804310D0 (en) 2008-03-07 2008-03-07 Screening for non-genotoxic carcinogens

Publications (2)

Publication Number Publication Date
WO2009109769A2 WO2009109769A2 (en) 2009-09-11
WO2009109769A3 true WO2009109769A3 (en) 2009-11-05

Family

ID=39327745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2009/000642 WO2009109769A2 (en) 2008-03-07 2009-03-09 Screening for non-genotoxic carcinogens

Country Status (6)

Country Link
US (1) US20110119780A1 (en)
EP (1) EP2268135A2 (en)
JP (1) JP2011512834A (en)
CA (1) CA2717705A1 (en)
GB (1) GB0804310D0 (en)
WO (1) WO2009109769A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202213141D0 (en) 2022-09-08 2022-10-26 Univ Dundee Immunodeficient non-human animals for assessing drug metabolism and toxicity

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006064197A2 (en) * 2004-12-13 2006-06-22 Iti Scotland Limited Transgenic animals for assessing drug metabolism and toxicity

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JP2000190480A (en) * 1998-12-25 2000-07-11 Canon Inc Ink print method and ink-printing apparatus
JP3741273B2 (en) * 1999-12-27 2006-02-01 セイコーエプソン株式会社 Ink set, recording method using the same, and recorded matter
ATE402022T1 (en) * 2000-04-10 2008-08-15 Seiko Epson Corp COATING LIQUID, IMAGE RECORDING METHOD AND A RECORD PRODUCED THEREFROM
JP3612704B2 (en) * 2000-04-18 2005-01-19 セイコーエプソン株式会社 Ink set for ink jet recording, recording method and recording apparatus for the same, and recorded matter
JP2002030237A (en) * 2000-05-10 2002-01-31 Seiko Epson Corp Ink composition for ink jet recording and contain pigment coated with resin
DE60125532T2 (en) * 2000-06-07 2007-04-26 Seiko Epson Corp. INK SET FOR INK RADIATION RECORDING
WO2002100959A1 (en) * 2001-05-02 2002-12-19 Seiko Epson Corporation Ink set and ink-jet recording method
JP4448649B2 (en) * 2001-08-10 2010-04-14 セイコーエプソン株式会社 Ink set and ink jet recording method
JP2003238857A (en) * 2002-02-18 2003-08-27 Seiko Epson Corp Ink set having wide color reproducibility in dark part, recording method and record
DE60335709D1 (en) * 2002-11-01 2011-02-24 Seiko Epson Corp INK COMBINATION, RECORDING METHOD USING THE INK COMBINATION, RECORDING DEVICE, RECORDING SYSTEM AND RECORDED OBJECT
US6942723B2 (en) * 2003-05-13 2005-09-13 Seiko Epson Corporation Water-base ink and ink set using the same
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006064197A2 (en) * 2004-12-13 2006-06-22 Iti Scotland Limited Transgenic animals for assessing drug metabolism and toxicity

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
HENDERSON COLIN J ET AL: "Transgenic analysis of human drug-metabolizing enzymes: preclinical drug development and toxicology.", MOLECULAR INTERVENTIONS SEP 2003, vol. 3, no. 6, September 2003 (2003-09-01), pages 331 - 343, XP002532986, ISSN: 1534-0384 *
NEBERT DANIEL W ET AL: "Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer.", THE JOURNAL OF BIOLOGICAL CHEMISTRY 4 JUN 2004, vol. 279, no. 23, 4 June 2004 (2004-06-04), pages 23847 - 23850, XP002532987, ISSN: 0021-9258 *
ROSS JILLIAN ET AL: "A NOVEL PANEL OF DOUBLE 'HUMANISED' & KNOCKOUT PXR AND CAR MOUSE MODELS", DRUG METABOLISM REVIEWS, vol. 40, no. Suppl. 1, 2008, & 10TH EUROPEAN REGIONAL MEETING OF THE INTERNATIONAL-SOCIETY-FOR-THE-S TUDY-OF-XENOBIOTICS; VIENNA, AUSTRIA; MAY 18 -21, 2008, pages 114 - 115, XP002532990, ISSN: 0360-2532 *
SCHEER NICO ET AL: "A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response.", THE JOURNAL OF CLINICAL INVESTIGATION SEP 2008, vol. 118, no. 9, September 2008 (2008-09-01), pages 3228 - 3239, XP002532989, ISSN: 0021-9738 *
STANLEY LESLEY A ET AL: "PXR and CAR: Nuclear receptors which play a pivotal role in drug disposition and chemical toxicity", DRUG METABOLISM REVIEWS, MARCEL DEKKER, NEW YORK, NY, US, vol. 38, no. 3, 1 January 2006 (2006-01-01), pages 515 - 597, XP008095775, ISSN: 0360-2532 *
YANG QIAN ET AL: "The PPAR alpha-humanized mouse: a model to investigate species differences in liver toxicity mediated by PPAR alpha.", TOXICOLOGICAL SCIENCES : AN OFFICIAL JOURNAL OF THE SOCIETY OF TOXICOLOGY JAN 2008, vol. 101, no. 1, January 2008 (2008-01-01), pages 132 - 139, XP002532988, ISSN: 1096-6080 *

Also Published As

Publication number Publication date
US20110119780A1 (en) 2011-05-19
GB0804310D0 (en) 2008-04-16
JP2011512834A (en) 2011-04-28
WO2009109769A2 (en) 2009-09-11
CA2717705A1 (en) 2009-09-11
EP2268135A2 (en) 2011-01-05

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