WO2009103739A1 - Heterocyclic inhibitors of stearoyl-coa desaturase - Google Patents
Heterocyclic inhibitors of stearoyl-coa desaturase Download PDFInfo
- Publication number
- WO2009103739A1 WO2009103739A1 PCT/EP2009/051926 EP2009051926W WO2009103739A1 WO 2009103739 A1 WO2009103739 A1 WO 2009103739A1 EP 2009051926 W EP2009051926 W EP 2009051926W WO 2009103739 A1 WO2009103739 A1 WO 2009103739A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stearoyl
- coa desaturase
- heterocyclic inhibitors
- derivatives
- modulate
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Child & Adolescent Psychology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
Claims
Priority Applications (16)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2715947A CA2715947C (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-coa desaturase |
CN200980113852.9A CN102007123B (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-CoA desaturase |
EA201001315A EA022797B1 (en) | 2008-02-20 | 2009-02-18 | THIAZOLE DERIVATIVES AS STEAROYL-CoA- DESATURASE INHIBITORS, PHARMACEUTICAL COMPOSITION COMPRISING THEM, AND USE THEREOF |
MX2010009158A MX2010009158A (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-coa desaturase. |
EP09711989.5A EP2245029B1 (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-coa desaturase |
NZ587350A NZ587350A (en) | 2008-02-20 | 2009-02-18 | Thiazole derivatives featuring an imidazolidine or triazole derivative as inhibitors of stearoyl-CoA desaturase |
JP2010547169A JP5507474B2 (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-CoA desaturase |
AU2009216769A AU2009216769A1 (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-CoA desaturase |
UAA201010238A UA105000C2 (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-coa desaturase |
BRPI0907826 BRPI0907826A2 (en) | 2008-02-20 | 2009-02-18 | heterocyclic stearoyl coa desaturase inhibitors |
ZA2010/05725A ZA201005725B (en) | 2008-02-20 | 2010-08-11 | Heterocyclic inhibitors of stearoyl-coa desaturase |
IL207578A IL207578A (en) | 2008-02-20 | 2010-08-12 | Heterocyclic inhibitors of stearoyl-coa desaturase, pharmaceutical compositions comprising them and their use in the preparation of medicaments |
TNP2010000378A TN2010000378A1 (en) | 2009-02-18 | 2010-08-12 | Heterocyclic inhibitors of stearoyl-coa desaturase |
CUP2010000170A CU23890B1 (en) | 2008-02-20 | 2010-08-19 | ESTEAROIL-COA-DESATURASA HETEROCYCLIC INHIBITORS |
MA33156A MA32150B1 (en) | 2008-02-20 | 2010-09-09 | Heterocyclic inhibitors of stearoyl-coa desaturase |
HK10111248.5A HK1144808A1 (en) | 2008-02-20 | 2010-12-02 | Heterocyclic inhibitors of stearoyl-coa desaturase coa |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US3013708P | 2008-02-20 | 2008-02-20 | |
US61/030,137 | 2008-02-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009103739A1 true WO2009103739A1 (en) | 2009-08-27 |
Family
ID=40740143
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2009/051926 WO2009103739A1 (en) | 2008-02-20 | 2009-02-18 | Heterocyclic inhibitors of stearoyl-coa desaturase |
Country Status (29)
Country | Link |
---|---|
US (2) | US8049016B2 (en) |
EP (1) | EP2245029B1 (en) |
JP (2) | JP5507474B2 (en) |
KR (1) | KR101584826B1 (en) |
CN (1) | CN102007123B (en) |
AR (1) | AR070429A1 (en) |
AU (1) | AU2009216769A1 (en) |
BR (1) | BRPI0907826A2 (en) |
CA (1) | CA2715947C (en) |
CL (1) | CL2009000381A1 (en) |
CO (1) | CO6290655A2 (en) |
CR (1) | CR11629A (en) |
CU (1) | CU23890B1 (en) |
EA (1) | EA022797B1 (en) |
EC (1) | ECSP10010411A (en) |
HK (1) | HK1144808A1 (en) |
HN (1) | HN2010001647A (en) |
IL (1) | IL207578A (en) |
JO (1) | JO3014B1 (en) |
MA (1) | MA32150B1 (en) |
MX (1) | MX2010009158A (en) |
MY (1) | MY156317A (en) |
NZ (1) | NZ587350A (en) |
PE (1) | PE20091473A1 (en) |
SV (1) | SV2010003650A (en) |
TW (1) | TWI457338B (en) |
UA (1) | UA105000C2 (en) |
WO (1) | WO2009103739A1 (en) |
ZA (1) | ZA201005725B (en) |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011039358A1 (en) * | 2009-10-01 | 2011-04-07 | Novartis Ag | Pyrazole derivatives which modulate stearoyl-coa desaturase |
US8049016B2 (en) | 2008-02-20 | 2011-11-01 | Novartis Ag | Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes |
US8063084B2 (en) | 2006-08-15 | 2011-11-22 | Novartis Ag | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels |
US8829193B2 (en) | 2008-03-03 | 2014-09-09 | Novartis Ag | PIM kinase inhibitors and methods of their use |
US8987457B2 (en) | 2012-05-21 | 2015-03-24 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
US10973810B2 (en) | 2017-01-06 | 2021-04-13 | Yumanity Therapeutics, Inc. | Methods for the treatment of neurological disorders |
US11873298B2 (en) | 2017-10-24 | 2024-01-16 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
US12098146B2 (en) | 2020-01-24 | 2024-09-24 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EA200900820A1 (en) * | 2006-12-20 | 2010-02-26 | Новартис Аг | 2-substituted 5-member heterocycles as stearaoyl-soa-desaturase inhibitors (SSDs) |
CA2873060A1 (en) * | 2012-05-11 | 2013-11-14 | Abbvie Inc. | Nampt inhibitors |
CN109415371B (en) * | 2016-09-08 | 2021-07-09 | 四川科伦博泰生物医药股份有限公司 | 2-amido thiazole derivative and preparation method and application thereof |
WO2021083182A1 (en) * | 2019-10-28 | 2021-05-06 | 南京明德新药研发有限公司 | Uricosuric agent, synthetic method therefor, and pharmaceutical application thereof |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006034440A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
WO2007130075A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
WO2008024390A2 (en) * | 2006-08-24 | 2008-02-28 | Novartis Ag | 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders |
WO2008127349A2 (en) * | 2006-08-15 | 2008-10-23 | Novartis Ag | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH590266A5 (en) * | 1972-10-04 | 1977-07-29 | Ciba Geigy Ag | |
US4058617A (en) | 1972-10-04 | 1977-11-15 | Ciba-Geigy Corporation | Imidazoles and pharmaceutical composition |
IL44282A (en) | 1974-02-25 | 1979-01-31 | Ciba Geigy Ag | 1-(1-alkyl-4(5)nitro-imidazol-2-yl)-2-oxo-tetrahydroimidazole derivatives, their manufacture and pharmaceutical compositions containing them |
ATE257703T1 (en) | 1997-10-27 | 2004-01-15 | Takeda Chemical Industries Ltd | 1,3-THIAZOLES AS ADENOSINE A3 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ASTHMA, ALLERGIES AND DIABETES |
CA2381215A1 (en) | 1999-08-06 | 2001-02-15 | Takeda Chemical Industries, Ltd. | P38map kinase inhibitors |
CA2404384A1 (en) | 2000-03-30 | 2001-10-11 | Takeda Chemical Industries, Ltd. | Substituted 1,3-thiazole compounds, their production and use |
WO2002051442A1 (en) | 2000-12-26 | 2002-07-04 | Takeda Chemical Industries, Ltd. | Concomitant drugs |
WO2002100433A1 (en) | 2001-06-11 | 2002-12-19 | Takeda Chemical Industries, Ltd. | Medicinal compositions |
US20090192191A1 (en) | 2004-01-09 | 2009-07-30 | Braj Bhushan Lohray | Substituted hydroxamic acid derivatives as tnf inhibitors |
EP1621539A1 (en) | 2004-07-27 | 2006-02-01 | Aventis Pharma S.A. | Heterocycle -substituted cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors |
JP5149009B2 (en) * | 2004-09-20 | 2013-02-20 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | Pyridazine derivatives for inhibiting human stearoyl-CoA desaturase |
ATE486862T1 (en) * | 2006-06-05 | 2010-11-15 | Novartis Ag | ORGANIC COMPOUNDS |
CA2662574A1 (en) | 2006-09-22 | 2008-03-27 | Novartis Ag | Heterocyclic organic compounds |
GB0621452D0 (en) * | 2006-10-27 | 2006-12-06 | Ucl Business Plc | Therapy for liver disease |
EA200900820A1 (en) * | 2006-12-20 | 2010-02-26 | Новартис Аг | 2-substituted 5-member heterocycles as stearaoyl-soa-desaturase inhibitors (SSDs) |
JPWO2009101917A1 (en) * | 2008-02-13 | 2011-06-09 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Bicycloamine derivatives |
EP2245029B1 (en) | 2008-02-20 | 2015-04-15 | Novartis AG | Heterocyclic inhibitors of stearoyl-coa desaturase |
AU2009264242A1 (en) | 2008-06-27 | 2009-12-30 | Novartis Ag | Organic compounds |
-
2009
- 2009-02-18 EP EP09711989.5A patent/EP2245029B1/en active Active
- 2009-02-18 JP JP2010547169A patent/JP5507474B2/en not_active Expired - Fee Related
- 2009-02-18 PE PE2009000239A patent/PE20091473A1/en not_active Application Discontinuation
- 2009-02-18 WO PCT/EP2009/051926 patent/WO2009103739A1/en active Application Filing
- 2009-02-18 AU AU2009216769A patent/AU2009216769A1/en not_active Abandoned
- 2009-02-18 CA CA2715947A patent/CA2715947C/en not_active Expired - Fee Related
- 2009-02-18 MX MX2010009158A patent/MX2010009158A/en active IP Right Grant
- 2009-02-18 KR KR1020107020848A patent/KR101584826B1/en not_active IP Right Cessation
- 2009-02-18 CN CN200980113852.9A patent/CN102007123B/en not_active Expired - Fee Related
- 2009-02-18 NZ NZ587350A patent/NZ587350A/en not_active IP Right Cessation
- 2009-02-18 EA EA201001315A patent/EA022797B1/en not_active IP Right Cessation
- 2009-02-18 BR BRPI0907826 patent/BRPI0907826A2/en not_active IP Right Cessation
- 2009-02-18 UA UAA201010238A patent/UA105000C2/en unknown
- 2009-02-18 AR ARP090100560A patent/AR070429A1/en unknown
- 2009-02-18 MY MYPI2010003768A patent/MY156317A/en unknown
- 2009-02-19 CL CL2009000381A patent/CL2009000381A1/en unknown
- 2009-02-19 TW TW098105331A patent/TWI457338B/en not_active IP Right Cessation
- 2009-02-19 JO JOP/2009/0075A patent/JO3014B1/en active
- 2009-02-20 US US12/378,997 patent/US8049016B2/en not_active Expired - Fee Related
-
2010
- 2010-08-11 ZA ZA2010/05725A patent/ZA201005725B/en unknown
- 2010-08-12 CR CR11629A patent/CR11629A/en unknown
- 2010-08-12 IL IL207578A patent/IL207578A/en not_active IP Right Cessation
- 2010-08-19 CU CUP2010000170A patent/CU23890B1/en active IP Right Grant
- 2010-08-19 HN HN2010001647A patent/HN2010001647A/en unknown
- 2010-08-19 CO CO10102259A patent/CO6290655A2/en active IP Right Grant
- 2010-08-20 EC EC2010010411A patent/ECSP10010411A/en unknown
- 2010-08-20 SV SV2010003650A patent/SV2010003650A/en unknown
- 2010-09-09 MA MA33156A patent/MA32150B1/en unknown
- 2010-12-02 HK HK10111248.5A patent/HK1144808A1/en not_active IP Right Cessation
-
2011
- 2011-09-21 US US13/238,081 patent/US8318949B2/en not_active Expired - Fee Related
-
2014
- 2014-03-19 JP JP2014056951A patent/JP5813162B2/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006034440A2 (en) * | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
WO2007130075A1 (en) * | 2005-06-03 | 2007-11-15 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors |
WO2008127349A2 (en) * | 2006-08-15 | 2008-10-23 | Novartis Ag | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level |
WO2008024390A2 (en) * | 2006-08-24 | 2008-02-28 | Novartis Ag | 2- (pyrazin-2-yl) -thiazole and 2- (1h-pyraz0l-3-yl) -thiazole derivatives as well as related compounds as stearoyl-coa desaturase (scd) inhibitors for the treatment of metabolic, cardiovascular and other disorders |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8063084B2 (en) | 2006-08-15 | 2011-11-22 | Novartis Ag | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid levels |
US8293768B2 (en) | 2006-08-15 | 2012-10-23 | Novartis Ag | Organic compounds |
US8318949B2 (en) | 2008-02-20 | 2012-11-27 | Novartis Ag | Organic compounds |
US8049016B2 (en) | 2008-02-20 | 2011-11-01 | Novartis Ag | Thiazole derivatives which inhibit stearoyl-CoA desaturase enzymes |
US8829193B2 (en) | 2008-03-03 | 2014-09-09 | Novartis Ag | PIM kinase inhibitors and methods of their use |
CN102574841A (en) * | 2009-10-01 | 2012-07-11 | 诺瓦提斯公司 | Pyrazole derivatives which modulate stearoyl-coa desaturase |
WO2011039358A1 (en) * | 2009-10-01 | 2011-04-07 | Novartis Ag | Pyrazole derivatives which modulate stearoyl-coa desaturase |
US8987457B2 (en) | 2012-05-21 | 2015-03-24 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
US9173883B2 (en) | 2012-05-21 | 2015-11-03 | Novartis Ag | Ring-substituted N-pyridinyl amides as kinase inhibitors |
US11970486B2 (en) | 2016-10-24 | 2024-04-30 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
US10973810B2 (en) | 2017-01-06 | 2021-04-13 | Yumanity Therapeutics, Inc. | Methods for the treatment of neurological disorders |
US11873298B2 (en) | 2017-10-24 | 2024-01-16 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
US12098146B2 (en) | 2020-01-24 | 2024-09-24 | Janssen Pharmaceutica Nv | Compounds and uses thereof |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2245029A1 (en) | Heterocyclic inhibitors of stearoyl-coa desaturase | |
MX2009003080A (en) | Heterocyclic organic compounds. | |
WO2009156484A3 (en) | Organic compounds | |
WO2007143597A3 (en) | Organic compounds | |
MX2009006728A (en) | 2-substituted 5-membered heterocycles as scd inhibitors. | |
WO2008127349A3 (en) | Heterocyclic compounds suitable for the treatment of diseases related to elevated lipid level | |
JO3181B1 (en) | Derivatives of 1-Phenly -2- Pyridinyl Alkyl alcohols as Phosphodiesterase | |
MY148634A (en) | Pyridazinone derivatives | |
TN2010000203A1 (en) | Beta-lactamase inhibitors | |
WO2011032169A3 (en) | Pharmaceutical compositions and formulations including inhibitors of the pleckstrin homology domain and methods for using same | |
WO2008107478A8 (en) | Quinolinone derivatives as parp and tank inhibitors | |
GEP20156242B (en) | 2-arylimidazole derivatives as pde10a enzyme inhibitors | |
HK1154002A1 (en) | Imidazopyridazinecarbonitriles useful as kinase inhibitors | |
TNSN08373A1 (en) | Azolopyrimidines as inhibitors of cannabinoid 1 activity | |
WO2009117676A3 (en) | Novel piperidine derivatives as inhibitors of stearoyl-coa desaturase | |
MX2009004746A (en) | 1,2,4-triazole derivatives as sigma receptor inhibitors. | |
MX2010003368A (en) | Imidazole derivatives. | |
MX2008001538A (en) | 2-aminoaryl pyridines as protein kinases inhibitors. | |
GEP20156241B (en) | Heteroaromatic phenylimidazole derivatives as pde10a enzyme inhibitors | |
WO2008074824A3 (en) | Isoquinolinecarboxamides as inhibitors of stearoyl-coa desaturase (scd) | |
GB2466912A (en) | Compositions and methods for treating lysosomal disorders | |
MX2010006108A (en) | Inhibitors of stearoyl-coa desaturase. | |
TN2012000085A1 (en) | Pyrazole derivatives which modulate stearoyl-coa desaturase | |
WO2011047055A3 (en) | Novel mek inhibitors, useful in the treatment of diseases | |
WO2009097973A3 (en) | Imidazopyridazines as par1 inhibitors, production thereof, and use thereof as medicaments |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200980113852.9 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 09711989 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 207578 Country of ref document: IL Ref document number: 201011629 Country of ref document: CR Ref document number: 2009216769 Country of ref document: AU Ref document number: CR2010-011629 Country of ref document: CR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 587350 Country of ref document: NZ |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2715947 Country of ref document: CA Ref document number: 12010501866 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010547169 Country of ref document: JP Ref document number: 10102259 Country of ref document: CO Ref document number: D2010170 Country of ref document: CU Ref document number: MX/A/2010/009158 Country of ref document: MX Ref document number: 2009711989 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 6217/DELNP/2010 Country of ref document: IN |
|
ENP | Entry into the national phase |
Ref document number: 2009216769 Country of ref document: AU Date of ref document: 20090218 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PI 2010003768 Country of ref document: MY |
|
WWE | Wipo information: entry into national phase |
Ref document number: DZP2010000566 Country of ref document: DZ Ref document number: 201001315 Country of ref document: EA |
|
ENP | Entry into the national phase |
Ref document number: 20107020848 Country of ref document: KR Kind code of ref document: A |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01E Ref document number: PI0907826 Country of ref document: BR Free format text: APRESENTAR AS PRIMEIRAS FOLHAS, NUMERADAS, DO RELATORIO DESCRITIVO, DAS REIVINDICACOES E RESUMO, DA PETICAO INICIAL. |
|
REG | Reference to national code |
Ref country code: BR Ref legal event code: B01Y Ref document number: PI0907826 Country of ref document: BR Kind code of ref document: A2 Free format text: ANULADA A PUBLICACAO CODIGO 1.5 NA RPI NO 2538 DE 27/08/2019 POR TER SIDO INDEVIDA. |
|
ENP | Entry into the national phase |
Ref document number: PI0907826 Country of ref document: BR Kind code of ref document: A2 Effective date: 20100819 |