WO2009087652A3 - Pharmaceutical compositions, comprising calcitriol and calcium - Google Patents

Pharmaceutical compositions, comprising calcitriol and calcium Download PDF

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Publication number
WO2009087652A3
WO2009087652A3 PCT/IN2008/000684 IN2008000684W WO2009087652A3 WO 2009087652 A3 WO2009087652 A3 WO 2009087652A3 IN 2008000684 W IN2008000684 W IN 2008000684W WO 2009087652 A3 WO2009087652 A3 WO 2009087652A3
Authority
WO
WIPO (PCT)
Prior art keywords
calcium
calcitriol
pharmaceutical compositions
source
elemental
Prior art date
Application number
PCT/IN2008/000684
Other languages
French (fr)
Other versions
WO2009087652A2 (en
Inventor
Ashok Omray
Yogesh Sharad Bhide
Varsha Shashank Choudhary
Original Assignee
Usv Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Usv Limited filed Critical Usv Limited
Publication of WO2009087652A2 publication Critical patent/WO2009087652A2/en
Publication of WO2009087652A3 publication Critical patent/WO2009087652A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
    • A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4833—Encapsulating processes; Filling of capsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Abstract

The present invention discloses stable pharmaceutical compositions comprising calcitriol, source of elemental calcium and source of elemental zinc as active ingredients; wherein the calcitriol is present in a dosage unit which physically separates it from other active ingredients. The source of elemental calcium is Active Absorbable Algal Calcium (AAA Ca), also known as Triple A cal. The invention further discloses a process for preparation of said compositions.
PCT/IN2008/000684 2007-10-19 2008-10-17 Pharmaceutical compositions of calcitriol and mineral supplements WO2009087652A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2078MU2007 2007-10-19
IN2078/MUM/2007 2007-10-19

Publications (2)

Publication Number Publication Date
WO2009087652A2 WO2009087652A2 (en) 2009-07-16
WO2009087652A3 true WO2009087652A3 (en) 2009-10-22

Family

ID=40853540

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000684 WO2009087652A2 (en) 2007-10-19 2008-10-17 Pharmaceutical compositions of calcitriol and mineral supplements

Country Status (1)

Country Link
WO (1) WO2009087652A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8809284B2 (en) 2009-04-03 2014-08-19 Vdf Futureceuticals, Inc. Compositions and methods related to calcitriol
WO2011024208A1 (en) * 2009-08-24 2011-03-03 Colotech A/S Combination dosage form with acetylsalicylic acid, calcitriol and calcium
DE102011080942A1 (en) * 2011-08-15 2013-02-21 Robert Bosch Gmbh Method for manufacturing distribution element in bottling plant of pharmaceutical plant, involves forming perforations in wall of tubular base element
CN103784419B (en) * 2012-10-31 2016-03-30 成都国弘医药有限公司 A kind of soft capsule containing calcitriol and preparation method thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164569A (en) * 1976-04-19 1979-08-14 Chugau Seiyaku Kabushiki Kaisha Stabilized soft gelatin capsule composition of 1 α-hydroxy-vitamin D
EP0335140A1 (en) * 1988-03-23 1989-10-04 Teva Pharmaceutical Industries Limited Compositions for the treatment of osteoporosis in humans
US6509326B1 (en) * 1991-05-06 2003-01-21 The Procter & Gamble Company Combined calcium and vitamin D supplements
US20070098819A1 (en) * 2005-11-02 2007-05-03 Susan Thys-Jacobs Micronutrient supplement with calcium, vitamin D or calcium & vitamin D combination for premenstrual syndrome, postpartum depression, depression and panic attacks

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164569A (en) * 1976-04-19 1979-08-14 Chugau Seiyaku Kabushiki Kaisha Stabilized soft gelatin capsule composition of 1 α-hydroxy-vitamin D
EP0335140A1 (en) * 1988-03-23 1989-10-04 Teva Pharmaceutical Industries Limited Compositions for the treatment of osteoporosis in humans
US6509326B1 (en) * 1991-05-06 2003-01-21 The Procter & Gamble Company Combined calcium and vitamin D supplements
US20070098819A1 (en) * 2005-11-02 2007-05-03 Susan Thys-Jacobs Micronutrient supplement with calcium, vitamin D or calcium & vitamin D combination for premenstrual syndrome, postpartum depression, depression and panic attacks

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FUJITA T: "Active Absorbable Algal Calcium (AAA Ca): new Japanese technology for osteoporosis and calcium paradox disease.", THE JOURNAL OF THE ASSOCIATION OF PHYSICIANS OF INDIA JUL 2004, vol. 52, July 2004 (2004-07-01), pages 564 - 567, XP002543054, ISSN: 0004-5772 *
FUJITA TAKUO ET AL: "Reappraisal of Katsuragi calcium study, a prospective, double-blind, placebo-controlled study of the effect of active absorbable algal calcium (AAACa) on vertebral deformity and fracture.", JOURNAL OF BONE AND MINERAL METABOLISM 2004, vol. 22, no. 1, 2004, pages 32 - 38, XP002543053, ISSN: 0914-8779 *
TANG ET AL: "Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis", LANCET THE, LANCET LIMITED. LONDON, GB, vol. 370, no. 9588, 23 August 2007 (2007-08-23), pages 657 - 666, XP022211085, ISSN: 0140-6736 *

Also Published As

Publication number Publication date
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