WO2009074997A3 - A novel process for the preparation of crystalline magnesium salt of (s)-omeprazole di hydrate - Google Patents

A novel process for the preparation of crystalline magnesium salt of (s)-omeprazole di hydrate

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Publication number
WO2009074997A3
WO2009074997A3 PCT/IN2008/000063 IN2008000063W WO2009074997A3 WO 2009074997 A3 WO2009074997 A3 WO 2009074997A3 IN 2008000063 W IN2008000063 W IN 2008000063W WO 2009074997 A3 WO2009074997 A3 WO 2009074997A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
omeprazole
preparation
novel process
magnesium salt
methyl
Prior art date
Application number
PCT/IN2008/000063
Other languages
French (fr)
Other versions
WO2009074997A2 (en )
Inventor
Venkat Reddy Alla
Raghumitra Alla
Setti Jagan Mohan Gopi
Aruna Kumari Sirigiri
Sreenivasa Reddy Bodapati
Venkat Rami Reddy Nara
Original Assignee
Lee Pharma Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Disclosed herein is process for preparation of crystalline form of (S)-5-methoxy-2-[[(4- methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzimidazolemagnesium dihydrate which comprises: dissolving (S)-Omeprazole potassium in dimethyl formamide; reacting with magnesium chloride hexa hydrate; removing the salts from the mixture; and precipitating the (S)-Omeprazole magnesium di hydrate crystalline form by adding anti solvent. The anti-solvent used in the above process is selected from the group consisting of ketones such as acetone or methyl isobutyl ketone; esters such as ethyl acetate, and ethers like methyl tertiary butyl ether.
PCT/IN2008/000063 2007-12-10 2008-02-01 A novel process for the preparation of crystalline magnesium salt of (s)-omeprazole di hydrate WO2009074997A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IN2950CH2007 2007-12-10
IN2950/CHE/2007 2007-12-10

Publications (2)

Publication Number Publication Date
WO2009074997A2 true WO2009074997A2 (en) 2009-06-18
WO2009074997A3 true true WO2009074997A3 (en) 2009-12-30

Family

ID=40755958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IN2008/000063 WO2009074997A3 (en) 2007-12-10 2008-02-01 A novel process for the preparation of crystalline magnesium salt of (s)-omeprazole di hydrate

Country Status (1)

Country Link
WO (1) WO2009074997A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011012957A1 (en) * 2009-07-29 2011-02-03 Orchid Chemicals & Pharmaceuticals Ltd An improved process for the preparation of esomeprazole magnesium dihydrate
CN104844577A (en) * 2011-07-31 2015-08-19 连云港润众制药有限公司 Crystal forms of esomeprazole magnesium

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369085B1 (en) * 1997-05-30 2002-04-09 Astrazeneca Ab Form of S-omeprazole
US6511996B1 (en) * 1999-01-28 2003-01-28 Astrazeneca Ab Potassium salt of (s)-omeprazole
WO2004089935A1 (en) * 2003-04-10 2004-10-21 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
US20040248940A1 (en) * 2002-07-29 2004-12-09 Wolfgang Kromer Salt of (s)-pantoprazole and its hydrates
US20060004057A1 (en) * 1993-05-28 2006-01-05 Lindberg Per L New compounds
WO2007031845A2 (en) * 2005-09-14 2007-03-22 Glenmark Pharmaceuticals Limited Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation
US20070093533A1 (en) * 2005-10-26 2007-04-26 Hanmi Pharm.Co., Ltd. Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004057A1 (en) * 1993-05-28 2006-01-05 Lindberg Per L New compounds
US6369085B1 (en) * 1997-05-30 2002-04-09 Astrazeneca Ab Form of S-omeprazole
US20020198239A1 (en) * 1997-05-30 2002-12-26 Anders Kronstrom Potassium salt of S-omeprazole
US6511996B1 (en) * 1999-01-28 2003-01-28 Astrazeneca Ab Potassium salt of (s)-omeprazole
US20040248940A1 (en) * 2002-07-29 2004-12-09 Wolfgang Kromer Salt of (s)-pantoprazole and its hydrates
WO2004089935A1 (en) * 2003-04-10 2004-10-21 Hetero Drugs Limitd Novel crystalline forms of s-omeprazole magnesium
WO2007031845A2 (en) * 2005-09-14 2007-03-22 Glenmark Pharmaceuticals Limited Polymorphic forms of (s)-omeprazole magnesium salts and processes for their preparation
US20070093533A1 (en) * 2005-10-26 2007-04-26 Hanmi Pharm.Co., Ltd. Crystalline S-omeprazole strontium hydrate, method for preparing same, and pharmaceutical composition containing same

Also Published As

Publication number Publication date Type
WO2009074997A2 (en) 2009-06-18 application

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