WO2009072005A3 - Cxcl12 gamma a chemokine and uses thereof - Google Patents

Cxcl12 gamma a chemokine and uses thereof Download PDF

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Publication number
WO2009072005A3
WO2009072005A3 PCT/IB2008/003838 IB2008003838W WO2009072005A3 WO 2009072005 A3 WO2009072005 A3 WO 2009072005A3 IB 2008003838 W IB2008003838 W IB 2008003838W WO 2009072005 A3 WO2009072005 A3 WO 2009072005A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemokine
cxcl12
gamma
cxcl12 gamma
immobilise
Prior art date
Application number
PCT/IB2008/003838
Other languages
French (fr)
Other versions
WO2009072005A2 (en
Inventor
Fernando Arenzana
Hugues Lortat-Jacob
Francoise Baleux
Original Assignee
Centre National De La Recherche Scientifique - C.N.R.S.
Institut Pasteur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National De La Recherche Scientifique - C.N.R.S., Institut Pasteur filed Critical Centre National De La Recherche Scientifique - C.N.R.S.
Priority to US12/682,943 priority Critical patent/US20110034383A1/en
Priority to EP08856180A priority patent/EP2197907A2/en
Publication of WO2009072005A2 publication Critical patent/WO2009072005A2/en
Publication of WO2009072005A3 publication Critical patent/WO2009072005A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1808—Epidermal growth factor [EGF] urogastrone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The present invention relates to fragments of CXCL12 Gamma A chemokine having improved chemotaxis activity in vivo defined by an unprecedented capacity to associate and immobilise on extracellular glycans.
PCT/IB2008/003838 2007-10-15 2008-10-15 Cxcl12 gamma a chemokine and uses thereof WO2009072005A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US12/682,943 US20110034383A1 (en) 2007-10-15 2008-10-15 Cxcl12 gamma a chemokine and uses thereof
EP08856180A EP2197907A2 (en) 2007-10-15 2008-10-15 Cxcl12 gamma a chemokine and uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97998407P 2007-10-15 2007-10-15
US60/979,984 2007-10-15

Publications (2)

Publication Number Publication Date
WO2009072005A2 WO2009072005A2 (en) 2009-06-11
WO2009072005A3 true WO2009072005A3 (en) 2010-04-08

Family

ID=40718276

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2008/003838 WO2009072005A2 (en) 2007-10-15 2008-10-15 Cxcl12 gamma a chemokine and uses thereof

Country Status (3)

Country Link
US (1) US20110034383A1 (en)
EP (1) EP2197907A2 (en)
WO (1) WO2009072005A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
WO2012075340A2 (en) 2010-12-01 2012-06-07 Alderbio Holdings Llc Anti-ngf compositions and use thereof
US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003012045A2 (en) * 2001-07-31 2003-02-13 Wayne State University Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans
US20030215792A1 (en) * 2000-06-02 2003-11-20 Hans Werner Mueller Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor, or at least on neuropeptide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030215792A1 (en) * 2000-06-02 2003-11-20 Hans Werner Mueller Nucleic acid molecule comprising a nucleic acid sequence coding for a chemokine, a neuropeptide precursor, or at least on neuropeptide
WO2003012045A2 (en) * 2001-07-31 2003-02-13 Wayne State University Hybrid proteins with neuregulin heparin-binding domain for targeting to heparan sulfate proteoglycans

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
ALTENBURG JEFFREY D ET AL: "A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities", JOURNAL OF VIROLOGY, vol. 81, no. 15, 1 August 2007 (2007-08-01), pages 8140 - 8148, XP002471819 *
BALEUX F ET AL: "SDF gamma: Synthesis and heparin binding sites identification", 29TH EUROPEAN PEPTIDE SYMPOSIUM; GDANSK, POLAND; SEPTEMBER 03 -08, 2006, September 2006 (2006-09-01), XP002556177, Retrieved from the Internet <URL:http://www.29eps.com/docs/0161.doc> [retrieved on 20091118] *
CLAPS CHRISTOPHER M ET AL: "Stromal derived growth factor-1alpha as a beacon for stem cell homing in development and injury.", CURRENT NEUROVASCULAR RESEARCH OCT 2005, vol. 2, no. 4, October 2005 (2005-10-01), pages 319 - 329, XP008115082, ISSN: 1567-2026 *
LAGURI CÉDRIC ET AL: "The Novel CXCL12gamma Isoform Encodes an Unstructured Cationic Domain Which Regulates Bioactivity and Interaction with Both Glycosaminoglycans and CXCR4", PLOS ONE, vol. 2, no. 10, E1110, 31 October 2007 (2007-10-31), pages 1 - 10, XP002471820 *
RUEDA PATRICIA ET AL: "The CXCL12gamma chemokine displays unprecedented structural and functional properties that make it a paradigm of chemoattractant proteins.", PLOS ONE 2008, vol. 3, no. 7, E2543, 2 July 2008 (2008-07-02), pages 1 - 12, XP002556179, ISSN: 1932-6203 *

Also Published As

Publication number Publication date
US20110034383A1 (en) 2011-02-10
EP2197907A2 (en) 2010-06-23
WO2009072005A2 (en) 2009-06-11

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