WO2009059054A3 - Bacteria strains an d bacteriocin produced therefrom - Google Patents

Bacteria strains an d bacteriocin produced therefrom

Info

Publication number
WO2009059054A3
WO2009059054A3 PCT/US2008/081866 US2008081866W WO2009059054A3 WO 2009059054 A3 WO2009059054 A3 WO 2009059054A3 US 2008081866 W US2008081866 W US 2008081866W WO 2009059054 A3 WO2009059054 A3 WO 2009059054A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
invention
strains
streptococcus
bacteriocin
produced
Prior art date
Application number
PCT/US2008/081866
Other languages
French (fr)
Other versions
WO2009059054A2 (en )
Inventor
Jeffrey Weiser
Suzanne Dawid
Original Assignee
The Trustees Of The University Of Pennsylvania
Children's Hospital Of Philadelphia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies

Abstract

This invention is relates to the control or treatment of bacterial infection or colonization through the use of novel bacteriocin producing Streptococcus strains. Specifically, the invention relates to methods and compositions comprising bacteriocins produced by upregularting the expression of the blp locus and downregulating the expressions of HtrA and CiaRH in a Streptococcus bacteria.
PCT/US2008/081866 2007-10-30 2008-10-30 Bacteria strains an d bacteriocin produced therefrom WO2009059054A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US89607 true 2007-10-30 2007-10-30
US61/000,896 2007-10-30

Publications (2)

Publication Number Publication Date
WO2009059054A2 true WO2009059054A2 (en) 2009-05-07
WO2009059054A3 true true WO2009059054A3 (en) 2009-09-17

Family

ID=40591762

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/081866 WO2009059054A3 (en) 2007-10-30 2008-10-30 Bacteria strains an d bacteriocin produced therefrom

Country Status (1)

Country Link
WO (1) WO2009059054A3 (en)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207411B1 (en) * 1995-04-12 2001-03-27 Teagasc Bacteriocins
US6448224B1 (en) * 1998-05-06 2002-09-10 St. Jude Children's Research Hospital Antibiotics and methods of using the same
US20020136712A1 (en) * 1997-10-31 2002-09-26 Fischetti Vincent Bacterial phage associated lysing enzymes for the prophylactic and therapeutic treatment of colonization and infections caused by streptococcus pneumoniae
US20030021811A1 (en) * 2000-03-16 2003-01-30 Weiser Jeffrey N. Modulating production of pneumococcal capsular polysaccharide
US20050249706A1 (en) * 1999-10-04 2005-11-10 Vion Pharmaceuticals, Inc. Compositions and methods for tumor-targeted delivery of effector molecules
US20060229244A1 (en) * 2004-09-27 2006-10-12 Robert Dorit Engineered bacteriocins and bacteriocin combinations and methods for treating bacterial based infections
US20070135339A1 (en) * 2005-12-08 2007-06-14 Stern Norman J Bacteriocin inducer peptides

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6207411B1 (en) * 1995-04-12 2001-03-27 Teagasc Bacteriocins
US20020136712A1 (en) * 1997-10-31 2002-09-26 Fischetti Vincent Bacterial phage associated lysing enzymes for the prophylactic and therapeutic treatment of colonization and infections caused by streptococcus pneumoniae
US6448224B1 (en) * 1998-05-06 2002-09-10 St. Jude Children's Research Hospital Antibiotics and methods of using the same
US20050249706A1 (en) * 1999-10-04 2005-11-10 Vion Pharmaceuticals, Inc. Compositions and methods for tumor-targeted delivery of effector molecules
US20030021811A1 (en) * 2000-03-16 2003-01-30 Weiser Jeffrey N. Modulating production of pneumococcal capsular polysaccharide
US20060229244A1 (en) * 2004-09-27 2006-10-12 Robert Dorit Engineered bacteriocins and bacteriocin combinations and methods for treating bacterial based infections
US20070135339A1 (en) * 2005-12-08 2007-06-14 Stern Norman J Bacteriocin inducer peptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DAWID ET AL: "The blp Bacteriocins of Streptococcus pneumoniae Mediate Intraspecies Competition both In Vitro and in Vivo", INFECTION AND IMMUNITY, vol. 75, January 2007 (2007-01-01), pages 443 - 451 *
DE SAIZIEU ET AL: "Microarray-Based Identification of a Novel Streptococcus pneumoniae Regulon Controlled by an Autoinduced Peptide", JOUMAL OF BACTERIOLOGY, vol. 182, September 2000 (2000-09-01), pages 4696 - 4703 *
KNUTSEN ET AL: "Two Separate Quorum-Sensing Systems Upregulate Transcription of the Same ABC Transporter in Streptococcus pneumoniae", JOUMAL OF BACTERIOLOGY, vol. 186, May 2004 (2004-05-01), pages 3078 - 3085 *

Also Published As

Publication number Publication date Type
WO2009059054A2 (en) 2009-05-07 application

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