WO2009054952A3 - Small molecule inhibitors of parp activity - Google Patents

Small molecule inhibitors of parp activity Download PDF

Info

Publication number
WO2009054952A3
WO2009054952A3 PCT/US2008/011990 US2008011990W WO2009054952A3 WO 2009054952 A3 WO2009054952 A3 WO 2009054952A3 US 2008011990 W US2008011990 W US 2008011990W WO 2009054952 A3 WO2009054952 A3 WO 2009054952A3
Authority
WO
WIPO (PCT)
Prior art keywords
small molecule
molecule inhibitors
parp activity
componds
parp
Prior art date
Application number
PCT/US2008/011990
Other languages
French (fr)
Other versions
WO2009054952A2 (en
Inventor
Bijoy Panicker
Dawoon Jung
Xiaokang Zhu
David E Smith
Dong Sung Lim
Original Assignee
Angion Biomedica Corp
Bijoy Panicker
Dawoon Jung
Xiaokang Zhu
David E Smith
Dong Sung Lim
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angion Biomedica Corp, Bijoy Panicker, Dawoon Jung, Xiaokang Zhu, David E Smith, Dong Sung Lim filed Critical Angion Biomedica Corp
Priority to EP08843240A priority Critical patent/EP2214667A2/en
Priority to AU2008317417A priority patent/AU2008317417A1/en
Publication of WO2009054952A2 publication Critical patent/WO2009054952A2/en
Publication of WO2009054952A3 publication Critical patent/WO2009054952A3/en
Priority to US12/592,163 priority patent/US20110098304A1/en
Priority to IL205299A priority patent/IL205299A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Componds and pharmaceutical compositions are provided that inhibit the activity of poly ADP-ribose synthetase (PARP). Such componds are useful in the treatment of various diseases, conditions and injuries such as stroke, myocardial infarction, ischemia-perfusion injury in various organs, traumatic brain injury, atherosclerosis, inflammatory diseases and cancer.
PCT/US2008/011990 2007-10-22 2008-10-22 Small molecule inhibitors of parp activity WO2009054952A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP08843240A EP2214667A2 (en) 2007-10-22 2008-10-22 Small molecule inhibitors of parp activity
AU2008317417A AU2008317417A1 (en) 2007-10-22 2008-10-22 Small molecule inhibitors of PARP activity
US12/592,163 US20110098304A1 (en) 2008-10-22 2009-11-19 Small molecule inhibitors of PARP activity
IL205299A IL205299A0 (en) 2007-10-22 2010-04-22 Parp inhibitor compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99991107P 2007-10-22 2007-10-22
US60/999,911 2007-10-22

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/592,163 Continuation US20110098304A1 (en) 2008-10-22 2009-11-19 Small molecule inhibitors of PARP activity

Publications (2)

Publication Number Publication Date
WO2009054952A2 WO2009054952A2 (en) 2009-04-30
WO2009054952A3 true WO2009054952A3 (en) 2009-08-06

Family

ID=40580286

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/011990 WO2009054952A2 (en) 2007-10-22 2008-10-22 Small molecule inhibitors of parp activity

Country Status (4)

Country Link
EP (1) EP2214667A2 (en)
AU (1) AU2008317417A1 (en)
IL (1) IL205299A0 (en)
WO (1) WO2009054952A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015008741A (en) * 2013-01-18 2015-11-06 Squibb Bristol Myers Co Phthalazinones and isoquinolinones as rock inhibitors.
MX365950B (en) 2013-03-13 2019-06-19 Flatley Discovery Lab Llc Pyridazinone compounds and methods for the treatment of cystic fibrosis.
US20150320706A1 (en) 2014-05-12 2015-11-12 Chiesi Farmaceutici S.P.A. Formulations and methods of treating alzheimer's disease and other proteinopathies by combination therapy
WO2020092638A1 (en) * 2018-10-30 2020-05-07 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors
CA3145827A1 (en) 2019-07-02 2021-01-07 Nuvation Bio Inc. Heterocyclic compounds as bet inhibitors

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020183325A1 (en) * 2000-10-30 2002-12-05 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US6635642B1 (en) * 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6677333B1 (en) * 1999-01-26 2004-01-13 Ono Pharmaceutical Co., Ltd. 2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient
US20060063767A1 (en) * 2004-08-26 2006-03-23 Kudos Pharmaceuticals Ltd Phthalazinone derivatives
WO2006036981A2 (en) * 2004-09-28 2006-04-06 Angion Biomedica Corp. Small molecule modulators of cytokine activity

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6635642B1 (en) * 1997-09-03 2003-10-21 Guilford Pharmaceuticals Inc. PARP inhibitors, pharmaceutical compositions comprising same, and methods of using same
US6677333B1 (en) * 1999-01-26 2004-01-13 Ono Pharmaceutical Co., Ltd. 2H-phthalazin-1-one derivatives and drug containing its derivatives as active ingredient
US20020183325A1 (en) * 2000-10-30 2002-12-05 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US20060063767A1 (en) * 2004-08-26 2006-03-23 Kudos Pharmaceuticals Ltd Phthalazinone derivatives
WO2006036981A2 (en) * 2004-09-28 2006-04-06 Angion Biomedica Corp. Small molecule modulators of cytokine activity

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
COCKCROFT, X. ET AL.: "Phthalazinones 2: Optimization and synthesis of novel potent inhibitors of poly(ADP-ribose)polymerase", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS., vol. 16, no. 4, 2006, pages 1040 - 1044, XP025106435 *

Also Published As

Publication number Publication date
IL205299A0 (en) 2010-12-30
WO2009054952A2 (en) 2009-04-30
AU2008317417A1 (en) 2009-04-30
EP2214667A2 (en) 2010-08-11

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