WO2009046992A1 - Method for the preparation of organic nitrates - Google Patents
Method for the preparation of organic nitrates Download PDFInfo
- Publication number
- WO2009046992A1 WO2009046992A1 PCT/EP2008/008579 EP2008008579W WO2009046992A1 WO 2009046992 A1 WO2009046992 A1 WO 2009046992A1 EP 2008008579 W EP2008008579 W EP 2008008579W WO 2009046992 A1 WO2009046992 A1 WO 2009046992A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acid
- group
- compound
- hydroxy
- residue
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 44
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- 229940082615 organic nitrates used in cardiac disease Drugs 0.000 title abstract description 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 66
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229910017604 nitric acid Inorganic materials 0.000 claims abstract description 28
- 239000002253 acid Substances 0.000 claims abstract description 27
- 238000006243 chemical reaction Methods 0.000 claims description 55
- 150000001875 compounds Chemical class 0.000 claims description 49
- 125000003118 aryl group Chemical group 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 27
- -1 aroyl anhydrides Chemical class 0.000 claims description 23
- 230000007062 hydrolysis Effects 0.000 claims description 16
- 238000006460 hydrolysis reaction Methods 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 10
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 10
- 125000005843 halogen group Chemical group 0.000 claims description 10
- 150000008065 acid anhydrides Chemical class 0.000 claims description 7
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 7
- 230000032050 esterification Effects 0.000 claims description 7
- 238000005886 esterification reaction Methods 0.000 claims description 7
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 7
- 238000005809 transesterification reaction Methods 0.000 claims description 7
- 229910004679 ONO2 Inorganic materials 0.000 claims description 6
- 125000004104 aryloxy group Chemical group 0.000 claims description 6
- 125000002252 acyl group Chemical group 0.000 claims description 5
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000003435 aroyl group Chemical group 0.000 claims description 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- 150000008064 anhydrides Chemical class 0.000 claims description 4
- 239000000460 chlorine Substances 0.000 claims description 4
- 229910052801 chlorine Inorganic materials 0.000 claims description 4
- 238000010931 ester hydrolysis Methods 0.000 claims description 4
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 229940098779 methanesulfonic acid Drugs 0.000 claims description 2
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 claims 2
- OUUQCZGPVNCOIJ-UHFFFAOYSA-N hydroperoxyl Chemical group O[O] OUUQCZGPVNCOIJ-UHFFFAOYSA-N 0.000 claims 1
- 230000008569 process Effects 0.000 abstract description 17
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 36
- 238000006396 nitration reaction Methods 0.000 description 33
- 239000000203 mixture Substances 0.000 description 25
- 239000007924 injection Substances 0.000 description 24
- 238000002347 injection Methods 0.000 description 24
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 18
- WERYXYBDKMZEQL-UHFFFAOYSA-N butane-1,4-diol Chemical compound OCCCCO WERYXYBDKMZEQL-UHFFFAOYSA-N 0.000 description 16
- 239000012530 fluid Substances 0.000 description 16
- 239000000243 solution Substances 0.000 description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 15
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 15
- 150000002009 diols Chemical class 0.000 description 12
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
- 239000000376 reactant Substances 0.000 description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 150000003077 polyols Chemical class 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 8
- 238000001816 cooling Methods 0.000 description 8
- 229920005862 polyol Polymers 0.000 description 8
- QGBMKPCHIDBDJI-UHFFFAOYSA-N 4-nitrooxybutyl acetate Chemical compound CC(=O)OCCCCO[N+]([O-])=O QGBMKPCHIDBDJI-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 239000006227 byproduct Substances 0.000 description 6
- 239000011521 glass Substances 0.000 description 6
- 229910052760 oxygen Inorganic materials 0.000 description 6
- 239000001301 oxygen Substances 0.000 description 6
- 239000011541 reaction mixture Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000007858 starting material Substances 0.000 description 6
- FLVQOAUAIBIIGO-UHFFFAOYSA-N 4-hydroxybutyl acetate Chemical compound CC(=O)OCCCCO FLVQOAUAIBIIGO-UHFFFAOYSA-N 0.000 description 5
- FBOGSWRRYABFKU-UHFFFAOYSA-N 4-hydroxybutyl nitrate Chemical compound OCCCCO[N+]([O-])=O FBOGSWRRYABFKU-UHFFFAOYSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 5
- 235000011054 acetic acid Nutrition 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 125000004432 carbon atom Chemical group C* 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- CSVRQVIXTDGUQL-UHFFFAOYSA-N 4-nitrooxybutyl 3-nitrobenzoate Chemical compound [O-][N+](=O)OCCCCOC(=O)C1=CC=CC([N+]([O-])=O)=C1 CSVRQVIXTDGUQL-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
- YGYAWVDWMABLBF-UHFFFAOYSA-N Phosgene Chemical compound ClC(Cl)=O YGYAWVDWMABLBF-UHFFFAOYSA-N 0.000 description 4
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
- 238000004821 distillation Methods 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 125000004430 oxygen atom Chemical group O* 0.000 description 4
- 229910052717 sulfur Inorganic materials 0.000 description 4
- 238000010626 work up procedure Methods 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 3
- AFZUKGRWEZTQFF-UHFFFAOYSA-N 4-hydroxybutyl 4-nitrobenzoate Chemical compound OCCCCOC(=O)C1=CC=C([N+]([O-])=O)C=C1 AFZUKGRWEZTQFF-UHFFFAOYSA-N 0.000 description 3
- NYDCYMUKFLXERS-UHFFFAOYSA-N 4-nitrooxybutyl 3-chloro-4-nitrobenzoate Chemical compound [O-][N+](=O)OCCCCOC(=O)C1=CC=C([N+]([O-])=O)C(Cl)=C1 NYDCYMUKFLXERS-UHFFFAOYSA-N 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000012267 brine Substances 0.000 description 3
- 150000004649 carbonic acid derivatives Chemical class 0.000 description 3
- 150000004650 carbonic acid diesters Chemical class 0.000 description 3
- 239000003054 catalyst Substances 0.000 description 3
- 239000007795 chemical reaction product Substances 0.000 description 3
- 125000004185 ester group Chemical group 0.000 description 3
- 239000002360 explosive Substances 0.000 description 3
- 150000002402 hexoses Chemical class 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 239000012044 organic layer Substances 0.000 description 3
- 150000002972 pentoses Chemical class 0.000 description 3
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 239000011550 stock solution Substances 0.000 description 3
- 239000011593 sulfur Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 2
- NXTNASSYJUXJDV-UHFFFAOYSA-N 3-nitrobenzoyl chloride Chemical compound [O-][N+](=O)C1=CC=CC(C(Cl)=O)=C1 NXTNASSYJUXJDV-UHFFFAOYSA-N 0.000 description 2
- NIASJQSOICOMDV-UHFFFAOYSA-N 3-nitrooxybutyl 4-nitrobenzoate Chemical compound [O-][N+](=O)OC(C)CCOC(=O)C1=CC=C([N+]([O-])=O)C=C1 NIASJQSOICOMDV-UHFFFAOYSA-N 0.000 description 2
- CUJYWJNYSJPWFY-UHFFFAOYSA-N 4-hydroxybutyl 3-chlorobenzoate Chemical compound OCCCCOC(=O)C1=CC=CC(Cl)=C1 CUJYWJNYSJPWFY-UHFFFAOYSA-N 0.000 description 2
- OTLNPYWUJOZPPA-UHFFFAOYSA-N 4-nitrobenzoic acid Chemical compound OC(=O)C1=CC=C([N+]([O-])=O)C=C1 OTLNPYWUJOZPPA-UHFFFAOYSA-N 0.000 description 2
- WNFHPWINRVVQRV-UHFFFAOYSA-N 4-nitrooxybutyl 4-nitrobenzoate Chemical compound [O-][N+](=O)OCCCCOC(=O)C1=CC=C([N+]([O-])=O)C=C1 WNFHPWINRVVQRV-UHFFFAOYSA-N 0.000 description 2
- FCMCSZXRVWDVAW-UHFFFAOYSA-N 6-bromo-1-hexanol Chemical compound OCCCCCCBr FCMCSZXRVWDVAW-UHFFFAOYSA-N 0.000 description 2
- NLWUXSNXDLMNRU-UHFFFAOYSA-N 6-nitrooxyhexyl acetate Chemical compound CC(=O)OCCCCCCO[N+]([O-])=O NLWUXSNXDLMNRU-UHFFFAOYSA-N 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000371 Esterases Proteins 0.000 description 2
- 239000005715 Fructose Substances 0.000 description 2
- 108090000604 Hydrolases Proteins 0.000 description 2
- 102000004157 Hydrolases Human genes 0.000 description 2
- 208000007976 Ketosis Diseases 0.000 description 2
- 229910002651 NO3 Inorganic materials 0.000 description 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- 150000001320 aldopentoses Chemical class 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical compound BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 238000004817 gas chromatography Methods 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 229910052736 halogen Inorganic materials 0.000 description 2
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical class CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 2
- 150000002584 ketoses Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 150000002823 nitrates Chemical class 0.000 description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 230000001590 oxidative effect Effects 0.000 description 2
- UWJJYHHHVWZFEP-UHFFFAOYSA-N pentane-1,1-diol Chemical class CCCCC(O)O UWJJYHHHVWZFEP-UHFFFAOYSA-N 0.000 description 2
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- 238000000746 purification Methods 0.000 description 2
- 238000010791 quenching Methods 0.000 description 2
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- PYMYPHUHKUWMLA-YUPRTTJUSA-N aldehydo-L-lyxose Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-YUPRTTJUSA-N 0.000 description 1
- 150000001312 aldohexoses Chemical class 0.000 description 1
- 150000001323 aldoses Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical group OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000002051 biphasic effect Effects 0.000 description 1
- 229910052794 bromium Inorganic materials 0.000 description 1
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical class CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 1
- BMRWNKZVCUKKSR-UHFFFAOYSA-N butane-1,2-diol Chemical compound CCC(O)CO BMRWNKZVCUKKSR-UHFFFAOYSA-N 0.000 description 1
- OWBTYPJTUOEWEK-UHFFFAOYSA-N butane-2,3-diol Chemical compound CC(O)C(C)O OWBTYPJTUOEWEK-UHFFFAOYSA-N 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229920001429 chelating resin Polymers 0.000 description 1
- AOGYCOYQMAVAFD-UHFFFAOYSA-N chlorocarbonic acid Chemical class OC(Cl)=O AOGYCOYQMAVAFD-UHFFFAOYSA-N 0.000 description 1
- 238000004587 chromatography analysis Methods 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000000183 esterificating effect Effects 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 150000002243 furanoses Chemical class 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 229960003711 glyceryl trinitrate Drugs 0.000 description 1
- 231100001261 hazardous Toxicity 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- XXMIOPMDWAUFGU-UHFFFAOYSA-N hexane-1,6-diol Chemical compound OCCCCCCO XXMIOPMDWAUFGU-UHFFFAOYSA-N 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 description 1
- 239000011796 hollow space material Substances 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 125000001789 ketohexose group Chemical group 0.000 description 1
- 150000002574 ketohexoses Chemical class 0.000 description 1
- 150000002581 ketopentoses Chemical class 0.000 description 1
- 239000012263 liquid product Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- AKFJWRDCWYYTIG-ZDUSSCGKSA-N naproxcinod Chemical compound C1=C([C@H](C)C(=O)OCCCCO[N+]([O-])=O)C=CC2=CC(OC)=CC=C21 AKFJWRDCWYYTIG-ZDUSSCGKSA-N 0.000 description 1
- 229960003759 naproxcinod Drugs 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 239000002840 nitric oxide donor Substances 0.000 description 1
- JCZMXVGQBBATMY-UHFFFAOYSA-N nitro acetate Chemical compound CC(=O)O[N+]([O-])=O JCZMXVGQBBATMY-UHFFFAOYSA-N 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920000166 polytrimethylene carbonate Polymers 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229960004063 propylene glycol Drugs 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 150000003214 pyranose derivatives Chemical class 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 239000012048 reactive intermediate Substances 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000011973 solid acid Substances 0.000 description 1
- 238000012358 sourcing Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
- 125000004434 sulfur atom Chemical group 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- VTALQOYOTZKULH-UHFFFAOYSA-N undecyl nitrate Chemical compound CCCCCCCCCCCO[N+]([O-])=O VTALQOYOTZKULH-UHFFFAOYSA-N 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
Definitions
- the present invention relates to a process for the preparation of organic nitrates having at least one nitryloxy and at least one free hydroxy group or esterified hydroxy residue.
- esterified hydroxy residue represents a hydroxy group esterified with an acid or an acid anhydride other than nitric acid. Hydroxy groups esterified with nitric acid are referred to as nitryloxy groups.
- Organic nitrates having at least one nitryloxy group (esters of an alcohol with nitric acid) and at least one free hydroxy group are valuable building blocks.
- Several pharmaceutically active compounds contain nitryloxy groups which stimulate the endogenous production of nitric oxide and/or are substrates for nitric oxide synthase and/or cytochrome P450 by releasing nitric oxide (nitric oxide donors).
- An example for the combination of anti-inflammatory agents like 2-(5)-(6-methoxy-2-naphthyl)-propanoic acid (naproxene) with one of the above mentioned building blocks in the CINOD (COX-inhibiting-nitric oxide-donating) class is Naproxcinod
- organic nitrates especially nitrates with more than one nitryloxy group, like glycerol trinitrate
- organic nitrates are explosive and therefore difficult to handle even in diluted solution.
- use of highly corrosive acids and the need of management of large amounts aqueous nitrate waste render the industrial production of organic nitrates difficult.
- EP-A 0 359 335 discloses 6-acyloxy-l-hexanol nitrate among several alcohol nitrates, diol dinitrates and glyceryl trinitrate. 6-Acetyloxy-l-hexanol nitrate has been extracted from the reaction mixture obtained by nitration of 1 equivalent (eq.) 1,6-hexanediol with 2.2 eq. nitric acid in the presence of acetic acid.
- EP-A 0 361 888 discloses the preparation of heterocyclic esters of ⁇ -nitryloxy-alkan-1-ols having a straight C 2-H alkylene chain, particularly 3-nitryloxy-w-propanol, 6-nitryloxy- H-hexanol and 11-nitryloxy-H-undecanol by reacting the respective ⁇ -bromo-alkan-1-ol with AgNO 3 .
- WO-A 94/021248 discloses a method for the preparation of 5-acetoxy-l-pentanol nitrate and 9-acetoxy-l-nonanol nitrate by reacting 1 equivalent (1 eq.) of the respective diol with 4 eq. acetic anhydride and 2 eq. nitric acid.
- 1 equivalent (1 eq.) of the respective diol For exhaustive nitration of alcohols having 1 to 3 hydroxy groups the respective alcohol is reacted with 3 eq. acetic anhydride and 3 eq. nitric acid per hydroxy group. After extraction of the crude mixture the products have been separated by chromatography or crystallization. No data regarding purity, yield and efforts for work-up are given.
- a major disadvantage of this reaction is that acetyl nitrate formed in the reaction from acetic anhydride and nitric acid is a highly explosive compound.
- WO-A 98/25918 discloses the preparation of aralkyl esters of nitrated cycloaliphatic diols by reacting an aralkylic acid derivative with the respective mononitrated cycloaliphatic diol.
- the alcohols are prepared by nitration of the respective monohalogenated cycloaliphatic diol or by reacting the respective diol with acetic anhydride and nitric acid. No yields are given. The existence of the respective acetoxy derivative is not reported.
- WO-A 01/10814 discloses an improved method over WO-A 98/25918 regarding the preparation of 4-nitryloxybutyl 2-(6-methoxy-2-naphthyl)-propanoate wherein 4-nitryloxy- butan-1-ol (1,4-butanediol mononitrate, BDMN) is prepared according to methods known in the art.
- WO-A 2004/012659 discloses the nitration of 2-bromoethanol, 3-bromopropan-l-ol, 5-bromopentan-l-ol and 6-bromohexan-l-ol with AgNO 3 according to methods known in the art, and the subsequent esterification of the alcohol with phosgene to obtain the respective chloroformates. It also discloses the preparation of a mixture of 3-nitryloxy-2-(nitryloxy- methyl)propan-l-ol and 2-(nitryloxymethyl)propane-l,3-diol by reacting 2-(hydroxymethyl)- 1,3-propanediol with a mixture of acetic anhydride and nitric acid.
- WO-A 2004/043897 discloses a purification method of BDMN from mixtures obtained by nitration of 1 ,4-butanediol with "stabilized” nitric acid according to the method also disclosed in WO-A 2004/043898.
- WO-A 2004/043898 discloses the preparation of ⁇ -nitryloxy-alkane-1 -ols having a straight or branched C 2-6 alkylene chain by reacting the respective diol with "stabilized” nitric acid. Reported yields are about 37%. The crude product is subject to unspecified "subsequent purification".
- WO-A 2006/006375 discloses the preparation of 6-nitryloxy-hexan-l-ol and 4-nitryloxy- butan-1-ol and as building blocks by reacting 6-bromo-hexan-l-ol with AgNO 3 and by reacting 4-bromobutyl acetate with AgNO 3 followed by hydrolysis of the 4-acetoxybutyl nitrate, respectively.
- a persistent aim of the chemical industry is to constantly improve and control chemical reactions. Greater control over reactions may lead to, for example, improvements in safety, increase in reaction product yield and/or purity, or the isolation of valuable highly reactive intermediate products. In particular, greater control over reagent mixing, fluid flow, heat sinking/sourcing and catalytic efficiency is desirable.
- the technical problem to be solved by the present invention was to provide an alternative method for the preparation of nitryloxy alcohols starting from compounds having at least two hydroxy groups and wherein at least one hydroxy group shall be maintained after nitration either as a free hydroxy group or masked as an ester.
- a further problem to be solved was to establish said process in a robust and secure manner. Furthermore side reactions should be avoided in order to simplify the work-up procedures.
- the general concept should start with easily available compounds and should contain few reaction steps.
- a method for the preparation method for preparation of a compound having at least one nitryloxy group and at least one hydroxy group or an esterified hydroxy residue said esterified hydroxy group representing a hydroxy group esterified with an acid other than nitric acid and thus consisting of an acid moiety and oxygen, comprising reaction of a compound comprising at least one esterified hydroxy group and a least one free hydroxy group with nitric acid, optionally in the presence of another acid or acid anhydride, to obtain a compound wherein the at least one free hydroxy group is exhaustively nitrated, and, optionally, subsequent hydrolysis or transesterification of the at least one esterified hydroxy residue.
- the esterified hydroxy residue is stable enough under nitration reaction conditions.
- the instant process can be carried out in concentrations up to 15% because over-nitration is avoided.
- the instant process aims towards exhaustive nitration of all free hydroxy groups. Hydroxy groups which should be maintained for further reactions are masked as esters.
- compound comprising at least one esterified hydroxy group and a least one free hydroxy group generally represents an alcohol moiety having a di- or polyol main structure wherein at least one of the hydroxy groups is esterified with an acid moiety.
- di- or polyol main structure represents the free alcohol which is obtained after hydrolysis of the starting compound. Due to the various possibilties of protecting and esterificating di- and polyols it is not suitable to mention the suitable di- or polyol moiety itself but said corresponding main structure.
- Suitable diol main structures comprise for example C 2-18 -diols such as ethanediol, 1,2-prop- anediol, 1,3 -propanediol, 1 ,2-butanediol, 1,3-butanediol, 1 ,4-butanediol, 2,3-butanediol, pentanediols or hexanediols.
- the diol main structure is 1,4-butanediol.
- Suitable polyol main structures comprise for example glycerol, carbohydrates and derivatives such as free or protected aldoeses and ketoses.
- Aldoses and ketoses might be protected for example by reacting with acetone in form of their ketals.
- the carbohydrates are pentoses or hexoses such as aldo- and ketopentoses and aldo- and ketohexoses and derivatives thereof.
- pentoses and hexoses are each D- and L-lyxose, -xylose, -arabinose, -ribose, -deoxyribose, -ribulose, -allose, -altrose, -glucose, -mannose, -gulose, -idose, -galactose, -talose, -psicose, -fructose, -sorbose and -tagatose as well in their respective open chain, pyranose (cyclic hemiacetal of an aldohexose) and furanose (cyclic hemiacetal of an aldopentose or a cyclic hemiketal of a ketohexose) ring forms or after protection for example by reacting with acetone.
- pyranose cyclic hemiacetal of an aldohexose
- furanose cyclic hemi
- the polyol is selected from the group consisting of glycerol, D- and L-arabinose, -deoxyribose, -ribulose, -glucose, -mannose, -galactose, -fructose, and -sorbose.
- the term "acid moiety" which is part of the esterified hydroxy residue consists of a functional group comprising a hetero atom-carbon or a hetero atom-sulfur double bond such as carbonyl (-CO-), thiocarbonyl (-CS-), sulfinyl (-SO-) or sulfonyl (-SO 2 -) which is attached to oxygen and having also attached a further residue.
- said further residue is an alkyl or aryl group forming an acyl, aroyl, alkanesulfonyl and arenesulfonyl group.
- said further residue is attached via an oxygen, nitrogen or sulfur atom such as HO(CH 2 ) m O-, R 3 R 4 N- or R 5 S- groups, forming for example a carbonic acid diester, a carbamate or a thioester, wherein R 3 , R 4 and R 5 independently are selected from the group consisting of Ci-i 8 -alkyl and aryl groups as defined above, and wherein m is an integer from 2 to 18.
- the acid moiety of the at least one esterified hydroxy residue is selected from acyl, aroyl, alkanesulfonyl and arenesulfonyl groups, said acyl or alkanesulfonyl groups consisting of an alkyl moiety and a carbonyl or sulfonyl group respectively, said alkyl moiety being optionally further substituted with one or more halogen atoms, and said aroyl and arenesulfonyl groups consisting of an aryl moiety and a carbonyl or sulfonyl group respectively, said aryl moiety being optionally further substituted with one or more halogen atoms and/or one or more nitro, alkyl, alkoxy, aryl and aryloxy groups.
- Some aromatic moieties of the acid moiety may be subject to nitration also, thus requiring more equivalents nitric acid without limiting the general advantages of the inventive process.
- alkyl represents a linear or branched alkyl group.
- C 1-n -alkyl the alkyl group is meant to have 1 to n carbon atoms.
- Ci -6 -alkyl represents for example methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl, tert-bvityl, pentyl and hexyl.
- alkoxy represents a linear or branched alkoxy group.
- C 1-n -alkoxy the alkyl group is meant having 1 to n carbon atoms.
- C 1-6 -alkoxy represents for example methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy, sec-butoxy, tert-butoxy, pentyloxy and hexyloxy.
- aryl represents an aromatic mono, di- or tricyclic group having 6 to 14 carbon atoms, optionally comprising 1 to 4 ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur.
- the aryl moiety is further substituted as defined in the specific case.
- aryl means phenyl or naphthyl optionally being further substituted as mentioned above for aryl.
- aryloxy represents an aromatic mono, di- or tricyclic group having 6 to 14 carbon atoms directly bound via an ether oxygen atom, optionally comprising 1 to 4 ring heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur.
- the aryl moiety is further substituted as defined in the specific case.
- aryloxy means phenoxy or naphthoxy optionally being further substituted as mentioned above for aryloxy.
- aralkyl represents a C 1-8 alkyl group as defined above, substituted with an aryl moiety as defined above.
- alkanesulfonyl represents a C 1-8 alkyl group as defined above, substituted with a sulfonyl moiety.
- An example for alkanesulfonyl with a Ci alkyl group is the methanesulfonyl (mesyl) residue.
- isnesulfonyl represents an aryl group as defined above, substituted with a sulfonyl moiety.
- An example for arenesulfonyl with a tolyl moiety is the 4-toluenesulfonyl (tosyl) residue.
- halogen atom represents a fluorine, chlorine, bromine or iodine atom, preferably a chlorine or bromine atom.
- R 1 is selected from the group consisting of Q.is-alkyl and aryl, and wherein n is an integer from 2 to 18, to obtain a compound of the formula
- R 1 and n are as defined above.
- one hydroxy of two equivalents of the starting compound is esterified with a carbonic acid derivative.
- two equivalents of a nitrated compound having at least one nitroxy group and at least one hydroxy group or esterified hydroxy group will be released.
- two hydroxy groups of a starting compound having at least three hydroxy groups are protected from nitration by forming a cyclic carbonic acid diester.
- a nitrated compound having at least one nitroxy group and at least two hydroxy groups or esterified hydroxy groups will be released after hydrolysis or transesterification.
- R 2 is a halogen atom or a residue selected from the group consisting of O 2 NO(CH 2 ) m O- R 3 R 4 N- and R 5 S-, wherein R 3 , R 4 and R 5 independently are selected from the group consisting of C ⁇ is-alkyl and aryl groups as defined above, and wherein n and m independently are an integer from 2 to 18, to obtain a compound of the formula
- R 2 , R 3 , R 4 , R 5 , n and m are as defined above.
- n and m are the same is carried out.
- the ester group might also be subject to a process to exchange the ester group which has been used to carry out the nitration of the free hydroxy group(s) with another ester group.
- Transesterifi- cation can be carried out as well as known in the art.
- the hydrolysis may be carried out chemically or enzymatically.
- Chemical ester hydrolysis may be carried out in the presence of a base or acid catalyst.
- the catalyst is a base such as alkaline metal or earth alkaline metal hydroxide, alkaline metal or alkaline earth metal alkoxide, trimethylamine, triethylamine, ammonia and mixtures thereof.
- a suitable acidic catalyst might be selected from the group consisting of organic or inorganic acids, preferably of non-oxidizing acids. Examples for suitable organic acids are formic acid, acetic acid or propionic acid. Examples for suitable inorganic acids are HCl, HF or solid acids like montmorillonite or zeolithes.
- Ester cleaving enzymes belong to the "hydrolase” group having an EC 3 classification, more specifically they belong to the “esterase” group, having an EC 3.1 classification.
- the enzymes might be used as known in the art in their native form using microorganisms having a hydrolases and/or esterase activity, as extracts thereof or in more or less purified form.
- the compound comprising at least one esterified hydroxy residue and a least one free hydroxy group is obtained by esterification of a compound having at least two free hydroxy groups.
- esterification of a compound having at least two free hydroxy groups In the art methods are known for selective partial esterification.
- the compound comprising at least one esterified hydroxy residue and a least one hydroxy group is obtained by partial ester hydrolysis of a compound having at least two esterified hydroxy residues.
- the starting compound can be easily prepared from a diol or polyol by reacting with a carboxylic or sulfonic acid halogenide or anhydride or even may be commercially purchased.
- the nitrification may be carried out in the presence of another acid or acid anhydride beside nitric acid, wherein said another acid may support the nitrification.
- Suitable other acids or anhydrides are for example sulfuric acid, methanesulfonic acid, toluenesulfonic acid, alkanoic anhydrides or aroyl anhydrides.
- alkanoic and aroyl anhydrides are acetic anhydride or benzoic anhydride.
- a method for the preparation of a compound having at least one nitryloxy group and at least one hydroxy group or an esterif ⁇ ed hydroxy residue comprising reaction of a compound comprising at least one esterified hydroxy group and a least one free hydroxy group with nitric acid in a microreactor (MR), optionally in the presence of another acid or acid anhydride, to obtain a compound wherein the at least one free hydroxy group is exhaustively nitrated, and, optionally, subsequent hydrolysis or transesterification of the at least one esterified hydroxy residue
- said nitration reaction comprising mixing at least two fluids, wherein one of the at least two fluids comprising a compound having at least one ester and at least one nitro group (1 st reactant), and another fluid comprising nitric acid, optionally in the presence of another acid (2 nd reactant), and optionally further fluids, said mixing taking place in a microreactor (6) comprising at least one flow path (1) for one of the at least two fluids (A) comprising either the 1 st or 2 nd reactant, said flow path(s) comprising at least one reaction region (2), each reaction region comprising an injection point (3) for feeding the other one of the at least two fluids (B) comprising either the 2 nd or the 1 st reactant, a mixing zone (4) in which the at least two fluids contact each other and a reaction zone (5), and wherein the microreactor optionally provides one or more additional residence time volumes, and wherein in said method one of the at least two fluids comprising either the 1 s
- microreactor is used for a reactor which reaction volumes have dimensions (perpendicular to the flow direction) of about 10000 micrometers and less.
- the expression “necessary to reach complete hydroxy group nitration” means the amount which would have to be added to reach “theoretical" completion of the reaction for example in a single vessel. In a simple 1 : 1 reaction stoichiometry this would be equimolar amounts. For a 1 st reactant like monoacetyl glycerol at least two molar equivalents of a nitric acid is necessary to complete the reaction of double nitration. Diacetyl glycerol would require at least one molar equivalent to reach complete nitration.
- Fig. 1 and Fig. 2 show two examples of feeding a flow B at various injection points to a flow A.
- the microreactor (6) in Fig. 1 comprises one flow path with three injection points
- the microreactor (6) in Fig. 2 comprises two flow paths each having three injection points. There may be more than two flow paths present, as well as more than three injection points in each flow path.
- the 2 nd reactant may be fed at the injections points to a first flow generated by the fluid comprising the 1 st reactant.
- the injection points, the mixing zones and/or the reaction zones there are no structural limits regarding the injection points, the mixing zones and/or the reaction zones. Only for the reason of better understanding of the parts of the microreactor used in the present invention the micro reactors in Fig. 1 and Fig. 2 are depicted as a linear strung-out hollow space. Nevertheless, the flow path(s) (1) may be tortuously bent as known in the art. Furthermore, different mixing zones and/or reaction zones need not have the same dimensions in width or length. It is further not necessary to use a microreactor which contains all of the features mentioned above in one physical entity. It is also possible to externally connect additional injection points, mixing zones, reaction zones, each optionally cooled or heated, to a flow path.
- Feeding only a fraction of the amount necessary to reach completion of the nitration reaction while using more than one mixing zone and/or injection point leads to an increase the number of hot spots in the microreactor while the temperature rise in each hot spot is reduced as compared to typical micro reactors with only one mixing and reaction zone.
- one of the two compounds is diluted in the first flow comprising the other compound, formation of side products is reduced and yields are increased.
- the inventive method provides an improved control over reactions.
- a suitable microreactor for the inventive method may comprise additional structural elements such as temperature adjustable retention volumes, temperature adjustable premixing volumes and others known in the art.
- the reaction starts after contacting the reactive fluids A and B in the mixing zone (3) and continues in a reaction zone (3).
- the flow path(s) (1) has/have a width in the range of 10 to 10000 micrometers and a cross section of 0.1 square centimeters or less. More preferably the flow path width is in a range of 10 to 500 micrometers, or even more preferably in a range of 10 to 200 micrometers.
- heat or cooling independently is supplied to the reservoirs of reactants, injection point(s) (3), the mixing zone(s) (4) and/or the reaction zone(s) (5) or any other structural entity of the microreactor used.
- the heat or cooling is supplied by an external source. Said heat or cooling can be supplied to initiate, maintain and/or slow down the reaction.
- heat is supplied to initiate and/or maintain the reaction, whereas cooling is supplied to slow down the reaction. In rare cases heat may be supplied to slow down the reaction, whereas cooling may be supplied to initiate and/or maintain the reaction.
- the first flow (1) of fluids containing the reaction product is quenched after being discharged from the microreactor.
- Fast exothermic reactions which are almost completed when the reaction mixture has passed the mixing zone may require additional cooling while passing the reaction zone to suppress side product formation. Performing slow reactions to complete conversion often leads to side products.
- the product is isolated after quenching the reaction.
- reaction does not reach completion in the mixing zone for several nitration reactions it may be suitable to feed the discharged first flow from the reaction zone or the microreactor into an external retention volume for further reaction, for other nitration reactions it may be suitable after the last injection point to quench the first flow directly after being discharged from the reaction zone or from the microreactor before it reaches completion to avoid excessive formation of oxidative side-products.
- the temperature and thus the selectivity of the nitration reaction can be easily controlled with an increasing number of mixing zones and/or injection points.
- the inventive method is advantageously carried out with a microreactor comprising not more than 7 reaction regions (injection points, mixing zones, reaction zones), preferably 3 to 6 reaction regions. Most preferably the mixing zones above one can be used independently of the injection points.
- Suitable microreactors (MR) to be used in the instant process could be made of different materials (glass or metal) and may belong to different built systems provided they are built for reactions under corrosive conditions.
- Integrated microreactor entities wherein injection point(s), mixing zone(s) and reaction zone(s) are built in one physical entity or MR which are made from single elements (injection point(s), mixing zone(s) and reaction zone(s)) connected via external fittings are both suitable.
- MR temperature is adjusted by immersing in a temperature controlled bath without having any additional elaborated temperature adjustment systems in place or MR comprising an efficient internal temperature adjustment system wherein a temperature controlled fluid is fed to the outside surface of injection point(s), mixing zone(s) and reaction zone(s) to provide an efficient and quick temperature adjustment.
- the starting compound and the nitration reagent each can be fed in one or more inlet points.
- nitrates obtainable by the instant process comprising at least one nitryloxy group and at least one esterified hydroxy residue, comprising at least one acid moiety as mentioned above and at least one di- or polyol main structure mentioned above with the proviso of compounds wherein the acid moiety is acetate and the diol main structure is a linear C 2- i 8 -diol such as 4-acetoxy-l -butyl nitrate, 6-acetoxy-l-hexyl nitrate or 1 1-acetoxy-l 1-undecyl nitrate.
- R 1 is selected from the group consisting of C 2-I8 alkyl and aryl, and wherein n is an integer from 2 to 18.
- carbonic acid diesters carbonates
- two, optionally identical, residues are attached to a central carbonyl group via an oxygen atom and wherein each of the residues having at least one free hydroxy group.
- carbonic acid diesters wherein two, optionally identical, residues are attached to a central carbonyl group via an oxygen atom and wherein each of the residues having at least one nitryloxy group.
- Carbonates wherein the residues are not identical can be obtained by reacting a halogen carbonic acid monoester with a compound having at least two free hydroxy groups which is different from the residue already attached to the central carbonyl group.
- Said halogen carbonic acid monoesters are obtainable to methods known in the art by reacting phosgene with a compound having at least two free hydroxy groups.
- cyclic carbonic acid diesters wherein one residue is attached via two oxygen atoms to a central carbonyl group and the residue comprises at least one free hydroxy group. Additionally provided are, cyclic carbonic acid diesters wherein one residue is attached via two oxygen atoms to a central carbonyl group and wherein the residue comprises at least one nitryloxy group.
- R 2 is a halogen atom or a residue selected from the group consisting of O 2 NO(CH 2 X n O-, R 3 R 4 N- and R 5 S-, wherein R 3 , R 4 and R 5 independently are selected from the group consisting of Ci-jg-alkyl and aryl groups as defined above, and wherein n and m independently are an integer from 2 to 18, with the exception of compounds wherein R 2 is chlorine and n is an integer from 2 to 6.
- 3-nitrobenzoic acid 4-hydroxybutyl ester and 3-chlorobenzoic acid 4-hydroxybutyl ester have been prepared by reacting 1 ,4-butanediol with 3-nitrobenzoyl chloride or 3-chlorobenzoyl chloride, respectively.
- Example 10 Hydrolysis of 4-nitrobenzoic acid 4-nitryloxybutyl ester 4-Nitrobenzoic acid 4-nitryloxybutyl ester (2.84 g, 10 mmol) was dissolved in THF (20 mL) and charged with water (10 mL). After cooling to 0 °C 1 M aqueous NaOH (10 mL) was added drop-wise. After the addition, the mixture was stirred another 1 h at 0 0 C. THF was removed from the reaction mixture by reducing pressure. Then the solution was extracted with CH 2 Cl 2 (3x20 mL). The mixture of the combined organic layers was washed with brine (20 mL) and dried over MgSO 4 . After filtration and removing the solvent BDMN has been obtained as yellow oil (1.26 g, 94%).
- Examples 11 and 12 Hydrolysis of 3-nitrobenzoic acid 4-nitryloxybutyl ester and 3-chloro-4-nitrobenzoic acid 4-nitryloxybutyl ester According to example 10, hydrolysis of 3-nitrobenzoic acid 4-nitryloxybutyl ester and 3-chloro-4-nitrobenzoic acid 4-nitryloxybutyl ester have been carried out. In both cases BDMN was obtained in 94% and 90% yields, respectively.
- Example 13 Preparation of acetic acid 4-nitryloxybutyl ester in a microreactor Two stock solutions were prepared for reaction in a microreactor (MR). Feed-1 solution was prepared by mixing of 1 ,4-butanediol monoacetate (91.79% purity, main impurity is 1,4-di- acetate, 177.0 g) with CH 2 Cl 2 (1350 mL, 1800 g). Feed-2 solution was prepared by mixing in a glass bottle at room temperature 100% nitric acid (85.2 g), 98% sulfuric acid (338.3 g) and water (24.45 g).
- MR microreactor
- Feed-1 and Feed-2 solutions are then fed at 17.50 g/min and 4.23 g/min flowrate, respectively, to a Corning glass microreactor (internal volume 10 mL) with integrated heat-exchanger structures thermostated at 25 0 C.
- the reactor outlet was quenched in water.
- the resulting biphasic system was stirred for 5 minutes, the aqueous phase discarded and the organic phase washed with the same weight of aqueous 5% NaHCO 3 .
- Yield of acetic acid 4-nitryloxybutyl ester is about 93%.
- Example 14 4-nitrobenzoic acid 3-nitryloxybutyl ester in a micro reactor
- the reactor outlet once the system runs steadily, was gathered during 1 min in a glass flask containing 20 g of cold water and further diluted with 3O g of dichloromethane, resulting in a slightly trouble organic layer.
- the separated and dried organic matter contained 4-nitrobenzoic 3-nitrooxybutyl ester and 4-nitrobenzoic acid, 3-oxobutyl ester in a 5:3 molar ratio (by 1 H-NMR).
- Comparative Example 1 Preparation of BDMN according to WO-A 2004/043898 A stock solution of "stabilized" nitric acid was prepared by mixing fuming nitric acid
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Abstract
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CN200880121176.5A CN102083786A (en) | 2007-10-12 | 2008-10-10 | Method for the preparation of organic nitrates |
BRPI0818049 BRPI0818049A2 (en) | 2007-10-12 | 2008-10-10 | Method for the preparation of organic nitrates |
US12/682,479 US20100312003A1 (en) | 2007-10-12 | 2008-10-10 | Method for the preparation of organic nitrates |
EA201000560A EA201000560A1 (en) | 2007-10-12 | 2008-10-10 | METHOD OF OBTAINING ORGANIC NITRATES |
EP08837972A EP2200966A1 (en) | 2007-10-12 | 2008-10-10 | Method for the preparation of organic nitrates |
MX2010003970A MX2010003970A (en) | 2007-10-12 | 2008-10-10 | Method for the preparation of organic nitrates. |
CA2701978A CA2701978A1 (en) | 2007-10-12 | 2008-10-10 | Method for the preparation of organic nitrates |
JP2010528321A JP2011500519A (en) | 2007-10-12 | 2008-10-10 | Process for the preparation of organic nitrates |
IL205017A IL205017A0 (en) | 2007-10-12 | 2010-04-11 | Method for the preparation of organic nitrates |
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US96077807P | 2007-10-12 | 2007-10-12 | |
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US60/960778 | 2007-10-12 | ||
EP07020022A EP2048129A1 (en) | 2007-10-12 | 2007-10-12 | Method for the preparation of organic nitrates |
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US (1) | US20100312003A1 (en) |
EP (2) | EP2048129A1 (en) |
JP (1) | JP2011500519A (en) |
CN (1) | CN102083786A (en) |
BR (1) | BRPI0818049A2 (en) |
CA (1) | CA2701978A1 (en) |
EA (1) | EA201000560A1 (en) |
IL (1) | IL205017A0 (en) |
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WO2011120695A1 (en) | 2010-03-31 | 2011-10-06 | Lonza Ltd | Process for the production of esters of nitric acid |
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US20110054020A1 (en) * | 2009-05-05 | 2011-03-03 | Auspex Pharmaceuticals, Inc. | Napthylene inhibitors of cyclooxygenase |
TWI417276B (en) * | 2011-03-01 | 2013-12-01 | Everlight Chem Ind Corp | Anhydride derivatives of 2-(s)-(6-methoxy-2-naphtyl)-propanoic acid, preparation method and use thereof |
WO2012152438A1 (en) * | 2011-05-11 | 2012-11-15 | Nicox S.A. | Process for the preparation of nitrate acid ester of organic compounds |
US9464029B2 (en) | 2013-05-06 | 2016-10-11 | Basf Se | Method for producing nitroalkanes in a microstructured reactor |
CN103242165B (en) * | 2013-05-27 | 2015-05-13 | 西安嘉宏石化科技有限公司 | Synthesis method of nitrate |
CN206081607U (en) | 2016-10-08 | 2017-04-12 | 上海荣威塑胶工业有限公司 | Take children entertainment device of water skiing pad |
MX2019008104A (en) * | 2017-01-31 | 2019-10-17 | Kimberly Clark Co | Antibacterial composition including benzoic acid ester and methods of inhibiting bacterial growth utilizing the same. |
CN107381600B (en) * | 2017-07-21 | 2019-07-12 | 上海交通大学 | Method carbon-to-carbon rupture synthesis cyanide and prepare one-dimensional coiled material from two-dimensional material |
CN107721874B (en) * | 2017-11-20 | 2020-05-19 | 南京工业大学 | Method for preparing nitrate compounds by adopting micro-flow field reaction technology |
CN108586477B (en) * | 2018-07-03 | 2019-10-29 | 鲁南制药集团股份有限公司 | A kind of method of micro passage reaction synthesis 5- Isosorbide Mononitrate |
CN112703179A (en) * | 2018-09-14 | 2021-04-23 | 帝斯曼知识产权资产管理有限公司 | Method for preparing omega-nitrooxy-1-alkanol |
US10703707B2 (en) | 2018-11-07 | 2020-07-07 | Industrial Technology Research Institute | Method for preparing nitrate ester |
WO2021214145A1 (en) * | 2020-04-22 | 2021-10-28 | Dsm Ip Assets B.V. | Process for nitrate ester formation of an alpha,omega-alkanediol monoacylate |
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WO2011120695A1 (en) | 2010-03-31 | 2011-10-06 | Lonza Ltd | Process for the production of esters of nitric acid |
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MX2010003970A (en) | 2010-06-25 |
EP2048129A1 (en) | 2009-04-15 |
IL205017A0 (en) | 2010-11-30 |
TW200932711A (en) | 2009-08-01 |
JP2011500519A (en) | 2011-01-06 |
CN102083786A (en) | 2011-06-01 |
BRPI0818049A2 (en) | 2015-03-31 |
EP2200966A1 (en) | 2010-06-30 |
CA2701978A1 (en) | 2009-04-16 |
EA201000560A1 (en) | 2010-10-29 |
US20100312003A1 (en) | 2010-12-09 |
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