WO2009034958A1 - Protein stabilizer, method for producing the same, method for using protein stabilizer, and method for stabilizing protein - Google Patents

Protein stabilizer, method for producing the same, method for using protein stabilizer, and method for stabilizing protein Download PDF

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Publication number
WO2009034958A1
WO2009034958A1 PCT/JP2008/066206 JP2008066206W WO2009034958A1 WO 2009034958 A1 WO2009034958 A1 WO 2009034958A1 JP 2008066206 W JP2008066206 W JP 2008066206W WO 2009034958 A1 WO2009034958 A1 WO 2009034958A1
Authority
WO
WIPO (PCT)
Prior art keywords
protein
stabilizer
protein stabilizer
producing
same
Prior art date
Application number
PCT/JP2008/066206
Other languages
French (fr)
Japanese (ja)
Inventor
Kouji Tamori
Eiji Takamoto
Toshihiro Ogawa
Original Assignee
Jsr Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jsr Corporation filed Critical Jsr Corporation
Priority to JP2009532181A priority Critical patent/JP5387850B2/en
Publication of WO2009034958A1 publication Critical patent/WO2009034958A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/52—Amides or imides
    • C08F220/54—Amides, e.g. N,N-dimethylacrylamide or N-isopropylacrylamide
    • C08F220/56—Acrylamide; Methacrylamide
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/14—Methyl esters, e.g. methyl (meth)acrylate

Abstract

Disclosed is a protein stabilizer containing a water-soluble polymer which is produced by polymerizing a monomer mixture containing a monomer (A) which forms a homopolymer having a lower critical solution temperature of not less than 0˚C but not more than 80˚C when homopolymerized, and a monomer (B) which forms a nonionic water-soluble homopolymer having no lower critical solution temperature when homopolymerized.
PCT/JP2008/066206 2007-09-12 2008-09-09 Protein stabilizer, method for producing the same, method for using protein stabilizer, and method for stabilizing protein WO2009034958A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009532181A JP5387850B2 (en) 2007-09-12 2008-09-09 Protein stabilizer and method for producing the same, method for using protein stabilizer, and method for stabilizing protein

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007236121 2007-09-12
JP2007-236121 2007-09-12

Publications (1)

Publication Number Publication Date
WO2009034958A1 true WO2009034958A1 (en) 2009-03-19

Family

ID=40451965

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/066206 WO2009034958A1 (en) 2007-09-12 2008-09-09 Protein stabilizer, method for producing the same, method for using protein stabilizer, and method for stabilizing protein

Country Status (2)

Country Link
JP (1) JP5387850B2 (en)
WO (1) WO2009034958A1 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010196048A (en) * 2009-01-30 2010-09-09 Kose Corp Novel water-soluble polymer, and cosmetic material or skin preparation for external use containing the same
JP2018165300A (en) * 2017-03-28 2018-10-25 藤倉化成株式会社 Method for reversible addition-fragmentation chain transfer polymerization, acrylic polymer, and acrylic block copolymer
JP2019142787A (en) * 2018-02-16 2019-08-29 Jsr株式会社 Protein stabilizer
CN113264997A (en) * 2021-04-13 2021-08-17 康汉医药(广州)有限公司 Method for storing protein medicine under normal temperature and high temperature conditions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10513433A (en) * 1993-02-02 1998-12-22 ゾーマ コーポレイション Pharmaceutical composition containing protein and surfactant with improved bactericidal and penetrating properties
JP2003289861A (en) * 2002-04-03 2003-10-14 San Contact Lens:Kk Modifying carrier for stabilizing proteolytic enzyme, proteolytic enzyme chemically modified by the modifying carrier and method for producing the proteolytic enzyme
JP2006516038A (en) * 2002-08-09 2006-06-15 オタワ ヘルス リサーチ インスティテュート Biosynthetic substrates and uses thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10513433A (en) * 1993-02-02 1998-12-22 ゾーマ コーポレイション Pharmaceutical composition containing protein and surfactant with improved bactericidal and penetrating properties
JP2003289861A (en) * 2002-04-03 2003-10-14 San Contact Lens:Kk Modifying carrier for stabilizing proteolytic enzyme, proteolytic enzyme chemically modified by the modifying carrier and method for producing the proteolytic enzyme
JP2006516038A (en) * 2002-08-09 2006-06-15 オタワ ヘルス リサーチ インスティテュート Biosynthetic substrates and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BRYJAK ET AL.: "Storage stabilization and purification of enzyme by water-soluble synthetic polymers", ENZYME AND MICROBIAL TECHNOLOGY, vol. 16, no. 7, 1994, pages 616 - 621 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010196048A (en) * 2009-01-30 2010-09-09 Kose Corp Novel water-soluble polymer, and cosmetic material or skin preparation for external use containing the same
JP2018165300A (en) * 2017-03-28 2018-10-25 藤倉化成株式会社 Method for reversible addition-fragmentation chain transfer polymerization, acrylic polymer, and acrylic block copolymer
JP2019142787A (en) * 2018-02-16 2019-08-29 Jsr株式会社 Protein stabilizer
CN113264997A (en) * 2021-04-13 2021-08-17 康汉医药(广州)有限公司 Method for storing protein medicine under normal temperature and high temperature conditions

Also Published As

Publication number Publication date
JPWO2009034958A1 (en) 2010-12-24
JP5387850B2 (en) 2014-01-15

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