WO2009026934A1 - Catecholamine derivatives useful for the treatment of parkinson' s disease - Google Patents
Catecholamine derivatives useful for the treatment of parkinson' s disease Download PDFInfo
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- WO2009026934A1 WO2009026934A1 PCT/DK2008/050214 DK2008050214W WO2009026934A1 WO 2009026934 A1 WO2009026934 A1 WO 2009026934A1 DK 2008050214 W DK2008050214 W DK 2008050214W WO 2009026934 A1 WO2009026934 A1 WO 2009026934A1
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
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- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
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- C07D221/06—Ring systems of three rings
- C07D221/08—Aza-anthracenes
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- C—CHEMISTRY; METALLURGY
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- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Definitions
- the present invention relates to novel catecholamines and catecholamine derivatives, to processes for their preparation, pharmaceutical compositions containing them and their use in therapy. Further, the compounds of the invention may be useful as PET ligands.
- PD Parkinson's disease
- Dopamine is a chemical neurotransmitter, which is utilized by brain cells to transmit impulses to control or modulate peripheral muscle movement.
- PD is believed to be caused by a progressive deterioration of DA-containing neurons in the substantia nigra zona compacta of the brain.
- the degeneration of the DA-containing neurons results in reduced amounts of DA in the brain. This process is thought to disturb the nerve cell function such that impulses are not transmitted properly, resulting in a loss of muscle control and function.
- Apomorphine which belongs to this class of compounds, is used clinically in PD therapy albeit with a non- oral delivery (typically intermittent subcutaneous administration or daytime continuous infusion).
- Several clinical studies are ongoing with alternative delivery strategies for Apomorphine therapy in PD such as intranasal and sublingual formulations. However these efforts are yet to result in an option for the clinical treatment of PD.
- Direct DA receptor agonists are able to activate the DA autoreceptors as well as the postsynaptic DA receptors.
- the effects of autoreceptor stimulation appear to predominate when e.g. Apomorphine is administered at low doses, whereas at higher doses the attenuation of DA transmission is outweighed by the enhancement of postsynaptic receptor stimulation.
- the antipsychotic effects in man of low doses of e.g. Apomorphine are likely due to the autoreceptor stimulation [for a discussion of clinical data, see: Tamminga; J. Neurol. Trans., 109(3), 411 (2002)].
- L-DOPA is an efficacious PD drug (a prodrug of dopamine) with a poor PK profile leading to dyskinesia and other response fluctuations.
- Selective D2-agonists e.g. Pramipexole
- L-DOPA and Apomorphine are currently the most efficacious PD drugs and they stimulate both Dl and D2 receptors.
- geriatrics for preventing bradykinesia and depression and in the improvement of mental functions including various aspects of cognition as discussed above. It can have a positive effect in depressed patients, and it can be used in obesity as an anorectic agent. It can improve minimal brain dysfunction (MBD), narcolepsy, and potentially the negative, the positive as well as the cognitive symptoms of schizophrenia. Restless leg syndrome (RLS) and periodic limb movement disorder (PLMD) are alternative indications, which are clinically treated with DA-agonists. In addition, impotence and erectile dysfunction are also likely to be improved by treatment with DA-agonists.
- Adrogolide undergoes a high hepatic first-pass metabolism in man after oral dosing and, as a result, has a low oral bioavailability (app. 4%).
- IV intravenous Adrogolide has antiparkinson efficacy comparable to that of L-DOPA [Giardina, Williams; CNS Drug Reviews, 7, 305 (2001)].
- An alternative approach involves the 'masking' of the two hydroxyl groups in the catechol as the corresponding methylene-di- oxy (MDO) acetal, as the acetal derived from other aldehydes than formaldehyde, or as the ketal derived from various ketones.
- MDO methylene-di- oxy
- a mixed Dl-like/D2-like agonist giving continuous dopaminergic stimulation may fulfill such unmet needs.
- the present invention relates to novel catecholamine derivatives, which the inventors have found may offer suitable alternatives to current marketed treatments of neurodegenerative diseases such as PD and Huntington's disease and to the treatment of other indications discussed herein, such as eg. dyskinetic disorders, cognitive impairment and restless legs syndrome (RLS), and to compounds that are in vivo metabolizable prodrugs hereof.
- neurodegenerative diseases such as PD and Huntington's disease
- other indications discussed herein such as eg. dyskinetic disorders, cognitive impairment and restless legs syndrome (RLS), and to compounds that are in vivo metabolizable prodrugs hereof.
- Cognitive impairment can be experienced in several patients groups, e.g. schizophrenic, depressive or psychotic patients and patients with attention deficit hyperactivity disorder (ADHD), Parkinson's disease, mild cognitive impairment (MCI), dementia, anxiety, age associated memory impairment, Alzheimer's Disease or post-traumatic stress disorder and patients taking benzodiazepines or tricyclic antidepressants and in a range of neurodegenerative diseases in addition to Parkinson's Disease and Alzheimer's Disease.
- ADHD attention deficit hyperactivity disorder
- MCI mild cognitive impairment
- dementia anxiety, age associated memory impairment
- Alzheimer's Disease or post-traumatic stress disorder and patients taking benzodiazepines or tricyclic antidepressants and in a range of neurodegenerative diseases in addition to Parkinson's Disease and Alzheimer's Disease.
- cognitive impairment refers to the difficulties with attention, learning, memory and executive function (relevant reactions to external stimuli).
- the objective of the present invention is to provide novel compounds, which are both potent dopamine Dl -like and D2-like agonists, and which may be used in the treatment of neurological and psychiatric diseases
- a further objective of the present invention is to provide novel compounds for oral administration in the treatment of PD and other diseases or disorders, which responds favourably to an increased dopaminergic turnover.
- PET (positron emission tomography) analysis is an important tool in the diagnosis of PD.
- Some of the compounds of the invention have potential applications as PET ligands for imaging studies of the DA-receptors or as intermediates for the preparation of such ligands, which may, for example, be applied in receptor localization studies as well as for the determination of receptor occupancy determination for compounds with affinities for the DA receptors.
- a further objective is therefore to provide radiolabeled compounds of the present invention, which are considered to be valuable PET ligands.
- the present invention relates to compounds of formula I:
- R 3 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, cyclo- propyl, cyc/o-butyl, allyl, propargyl, hydroxyethyl, 3-fiuoropropyl and 2-fluoroethyl
- the C i-6 alkanoyl group means a straight-chain or branched-chain alkanoyl group containing from 1 to six carbon atoms, examples of which include a formyl group, an acetyl group, a pivaloyl group, and the like.
- the invention relates to compounds of formula I in the form of a substantially pure single enantiomer or a single diastereomer.
- the invention relates to compounds of formula I in the form of a mixture of enantiomers, a mixture of diastereomers, or a substantially pure polymorph.
- the invention relates to compounds of Formula I which have trans-fased ring systems. In another embodiment the invention relates to compounds of Formula I, which have czs-fused ring systems.
- the invention relates to compounds of Formula I wherein R 3 is selected from the group consisting of hydrogen, methyl, ethyl, n-propyl, allyl, and propargyl.
- R 3 is selected from the group consisting of cyc/ ⁇ -propyl, cyc/ ⁇ -butyl, and hydroxyethyl.
- the invention furthermore relates to compounds of Formula I wherein Ri and R 2 are both hydrogen and R 3 is selected from the group consisting of hydrogen, methyl, ethyl and n- propyl.
- the invention also relates to compounds of Formula I wherein Ri and R 2 are fused and form a methylene (CH 2 ) group, and R 3 is selected from the group consisting of hydrogen, methyl, ethyl and n-propyl, such as methyl and n-propyl.
- the compound is selected from one of the following specific compounds: trans- l-methyl-2,3,3a,4,9,9a-hexahydro-lH-benzo[f]indole-5,6-diol c/5-l-methyl-2,3,3a,4,9,9a-hexahydro-lH-benzo[f]indole-5,6-diol trans- l-n-propyl-2, 3, 3a,4, 9, 9a-hexahydro-lH-benzo[f]indole-5,6-diol czs- l-n-propyl-2,3,3a,4,9,9a-hexahydro-lH-benzo[f]indole-5,6-diol (4aR,10aR)-l,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol (4aS)
- 2,2-Dimethylpropionic acid (4aR, 10aR)-7-(2,2-dimethyl-propionyloxy)- 1 -methyl- l,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinolin-6-yl ester
- the present invention relates to radiolabeled compounds of Formula I and the use thereof in various biological assays such as PET-studies, in vivo binding studies and in vitro assays.
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt hereof, as a medicament.
- the compound of Formula I either as the free base, or as a pharmaceutically acceptable acid addition salt, or as a pharmaceutical composition, may be administered in any suitable way e.g. orally, buccally, sublingually, non-orally or parenterally, and the compound may be presented in any suitable form for such administration, e.g. orally in the form of tablets, capsules, powders, syrups, solutions or dispersions, non-orally in the form of eg. transdermal patches or parenterally in the form of dispersions or solutions for injection.
- the compound of Formula I is administered in the form of a solid pharmaceutical entity, suitably as a tablet or a capsule.
- the compounds of Formula I form pharmaceutically acceptable acid addition salts with a wide variety of organic and inorganic acids. Such salts are also part of this invention.
- a pharmaceutically acceptable acid addition salt of the compound of Formula I is formed from a pharmaceutically acceptable acid as is well known in the art.
- Such salts include the pharmaceutically acceptable salts listed in Journal of Pharmaceutical Science, 66,2-19 (1977) and are known to the skilled person.
- Typical inorganic acids used to form such salts include hydrochloric, hydrobromic, hydriodic, nitric, sulphuric, phosphoric, hypophosphoric, metaphosphoric, pyrophosphoric, and the like.
- Salts derived from organic acids such as aliphatic mono and dicarboxylic acids, phenyl substituted alkanoic acids, hydroxyalkanoic and hydroxyalkandioic acids, aromatic acids, aliphatic and aromatic sulfonic acids, may also be used.
- Such pharmaceutically acceptable salts thus include the chloride, bromide, iodide, nitrate, acetate, phenylacetate, trifluoroacetate, acrylate, ascorbate, benzoate, chlorobenzoate, dinitrobenzoate, hydroxybenzoate, methoxybenzoate, methylbenzoate, o-acetoxybenzoate, isobutyrate, phenylbutyrate, ⁇ -hydroxybutyrate, butyne-l,4-dicarboxylate, hexyne-1,4- dicarboxylate, caprate, caprylate, cinnamate, citrate, formate, fumarate, glycollate, heptanoate, hippurate, lactate, malate, maleate, hydroxymaleate, malonate, mandelate, mesylate, nicotinate, isonicotinate, oxalate, phthalate, teraphthalate, propiolate, propionate,
- Tablets may thus be prepared by mixing the active ingredient with ordinary adjuvants, fillers and diluents and subsequently compressing the mixture in a convenient tabletting machine.
- adjuvants, fillers and diluents comprise microcrystalline cellulose, corn starch, potato starch, lactose, mannitol, sorbitol talcum, magnesium stearate, gelatine, lactose, gums, and the like. Any other adjuvant or additive such as colourings, aroma, preservatives, etc. may also be used provided that they are compatible with the active ingredients.
- the tablet formulations according to the invention may be prepared by direct compression of a compound of Formula I in admixture with conventional adjuvants or diluents.
- a wet granulate or a melt granulate of a compound of Formula I, optionally in admixture with conventional adjuvants or diluents may be used for compression of tablets.
- Solutions of a compound of Formula I for injections may be prepared by dissolving the active ingredient and possible additives in a part of the solvent for injection, preferably sterile water, adjusting the solution to the desired volume, sterilisation of the solution and filling in suitable ampoules or vials.
- a suitable additive conventionally used in the art may be added, such as tonicity agents, preservatives, antioxidants, solubilising agents, etc.
- the active ingredient, eg. as the free base may be dissolved in a digestible or non-digestible oil, mixtures hereof or similar, to prepare an intramuscular depot formulation capable of releasing the active ingredient over a prolonged period of time.
- compositions of the compound of Formula I to be used in transdermal applications may optionally contain permeation activators to facilitate the passage of the active ingredient through the skin.
- the invention in another aspect, relates to a pharmaceutical composition
- a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, and one or more pharmaceutically acceptable carriers, diluents and excipients.
- a pharmaceutical composition comprising a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, wherein Ri and R 2 are both hydrogen and R 3 is selected from the group consisting of hydrogen, methyl, ethyl and n-propyl for non- oral administration, such as transdermal, nasal, buccal, intramuscular or subcutaneous administration.
- the invention provides the use of a compound of Formula I or a pharmaceutically acceptable acid addition salt thereof for the preparation of a medicament for the treatment of neurodegenerative disorders such as Parkinson's disease and Huntington's disease.
- the invention provides the use of a compound of Formula I or a pharmaceutically acceptable acid addition salt thereof for the preparation of a medicament for the treatment of psychoses, impotence, renal failure, heart failure or hypertension.
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, for the manufacture of a medicament for the treatment of cognitive impairment in a mammal.
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, for the manufacture of a medicament for the treatment of restless legs syndrome (RLS) or periodic limb movement disorder (PLMD).
- RLS restless legs syndrome
- PLMD periodic limb movement disorder
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, for the manufacture of a medicament for the treatment of movement disorders, poverty of movement, dyskinetic disorders, gait disorders or intention tremor in a mammal.
- the invention provides the use of a compound of Formula I or a pharmaceutically acceptable acid addition salt thereof for the treatment of neurodegenerative disorders such as Parkinson's disease and Huntington's disease.
- the invention provides the use of a compound of Formula I or a pharmaceutically acceptable acid addition salt thereof for the treatment of psychoses, impotence, renal failure, heart failure or hypertension.
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of cognitive impairment in a mammal.
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of restless legs syndrome (RLS) or periodic limb movement disorder (PLMD).
- RLS restless legs syndrome
- PLMD periodic limb movement disorder
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, for the treatment of movement disorders, poverty of movement, dyskinetic disorders, gait disorders or intention tremor in a mammal.
- the invention provides the use of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof, for the manufacture of medicaments, which are intended for oral administration, or for non-oral administration.
- the invention also provides a method of treating a mammal suffering from a neurodegenerative disorder such as Parkinson's disease and Huntington's disease comprising administering to the mammal a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof.
- a neurodegenerative disorder such as Parkinson's disease and Huntington's disease
- the invention also provides a method of treating a mammal suffering from psychoses, impotence, renal failure, heart failure or hypertension, comprising administering to the mammal a therapeutically effective amount of a compound of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof.
- the invention provides a method of treating a mammal suffering from a cognitive impairment, comprising administering to the mammal an effective amount of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof.
- the invention also relates to a method of treating a mammal suffering from restless legs syndrome (RLS) or periodic limb movement disorder (PLMD), comprising administering to the mammal a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable addition salt thereof.
- RLS restless legs syndrome
- PLMD periodic limb movement disorder
- the invention also relates in a separate aspect to a method of treating a mammal suffering from movement disorders, poverty of movement, dyskinetic disorders, gait disorders or intention tremor comprising administering to the mammal a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable acid addition salt thereof.
- the mammal is a human subject
- the therapeutically effective amount of a compound of Formula I, calculated as the daily dose of the compound of Formula (I) above as the free base, is suitably between 0.01 and 125 mg/day, more suitable between 0.05 and 100 mg/day, e.g. preferably between 0.1 and 50 mg/day.
- the daily dose of the compound of Formula I is between 1 and 10 mg/day.
- the daily dose of the compound of Formula I is less than about 1 mg/day.
- the daily dose of the compound of Formula I is about 0.1 mg/day.
- the invention provides an oral formulation comprising from 0.001 mg to 125 mg of a compound of Formula I.
- the invention provides an oral formulation comprising from 0.001 mg to 0.1 mg of a compound of Formula I.
- the invention provides an oral formulation comprising from 0.01 mg to 1 mg of a compound of Formula I.
- the invention provides an oral formulation comprising from 0.1 mg to 10 mg of a compound of Formula I.
- Figure 1 Dose-response curve for the concentration-dependent stimulation of intracellular Ca + release by dopamine in hD5-transfected CHO-GaI 6 cells.
- Figure 2 Crystal structure of example 2d2. The absolute configuration was determined by the anomalous scattering of the 'heavy' bromine atom.
- the compounds of the present invention contain two chiral centers (denoted with * in the below formula)
- the compounds of the invention therefore can exist in two different diastereomeric forms, the cis- and trans- isomers, which forms both fall under the scope of the present invention.
- ring-atoms of the compounds of the invention are numbered as follows:
- the diastereomeric forms further comprise two enantiomeric forms each, which means that the compounds of Formula I overall exist as the individual (R,R), (R,S), (S,S) and (S, R) enantiomers.
- the compounds of Formula I have been found to behave like orally active Apomorphine- analogues, which render them potentially useful in relation to treatment of Parkinson's disease and other diseases/disorders, which responds favorably to an increased dopaminergic turnover.
- a specific embodiment of the present invention relates to the use of a compound of Formula I or a pharmaceutically acceptable addition salt thereof for improving cognition in a mammal in a condition of cognitive impairment wherein the condition is associated with schizophrenia.
- the condition is associated with Parkinson's Disease.
- the condition is associated with dementia, such as AIDS dementia.
- the condition is associated with an anxiety disorder.
- the condition is associated with age associated memory impairment.
- the condition is associated with depression, including major depression, in particular in elderly.
- the condition is associated with the use of benzodiazepines.
- the condition is associated with the use of tricyclic antidepressants.
- the condition is associated with Alzheimer's Disease.
- the condition is associated with attention deficit hyperactivity disorder (ADHD).
- PTSD post-traumatic stress disorder
- the present invention relates to the use of a compound of Formula I or a pharmaceutically acceptable addition salt thereof for the treatment of dyskinesias in a mammal.
- the present invention relates to the use of a compound of Formula I or a pharmaceutically acceptable addition salt thereof for the treatment of a mammal suffering from depression, such as major depresion, bipolar disorder or anxiety.
- Apomorphine is a mixed Dl-like/D2-like agonist:
- Dl -like agonist (be it selective for either subtype or a mixed D1/D5 agonist) could have important applications in the treatment of cognitive impairment in e.g. psychosis, PD, and Alzheimer's disease (AD), and Huntington's disease. This might well be the case also for dual action D1/D2 agonists, such as the compounds of Formula I.
- the invention also relates to compounds of Formula I to be used as PET ligands or as intermediates therefore.
- the desired radio label can be introduced by the use of radio-labeled precursors, including ⁇ C-labelled precursors such as [ ⁇ C]methyl iodide, [ ⁇ C]methyl trifiate, etc.
- the compounds may also be labeled with 3 H, 18 F or.
- a radiolabeled compound of Formula I in which the radio label is selected from 11 C, 3 H, 18 F or 123 I.
- the radiolabeled compounds of Formula I wherein Ri and R 2 are both hydrogen are particularly preferred as radioligands.
- Another embodiment relates to the free base of a compound of Formula I, or a salt hereof, or a pharmaceutical composition hereof and the uses as described herein, wherein the compound of Formula I has a tr ⁇ ns-diastereomeric excess of at least 10% (10% tr ⁇ ns-diastereomeric excess means that the ratio of the trans- to the cz ' s-diastereoisomer is 55:45 in the mixture in question), at least 25%, at least 50%, at least 70%, at least 80%, at least 90%, at least 95%, at least 97%, preferably at least 98%.
- a further embodiment relates to the free base of a compound of Formula I, or a salt hereof, or a pharmaceutical composition hereof and the uses as described herein, wherein the compound of Formula I has an enantiomeric excess of at least 10% (for example, 10% enantiomeric excess for a compound of Formula I having (4aR,10aR) configuration means that the ratio between the (4aR,10aR)- and (4aS,10aS)-enantiomers is 55:45 in the mixture in question), at least 25%, at least 50%, at least 70%, at least 80%, at least 90%, at least 95%, at least 97%, preferably at least 98%.
- 10% enantiomeric excess for a compound of Formula I having (4aR,10aR) configuration means that the ratio between the (4aR,10aR)- and (4aS,10aS)-enantiomers is 55:45 in the mixture in question
- MDO methylenedioxy
- the invention thus also relates to compounds of Formula I wherein Ri and R 2 are fused and form a methylene (CH 2 ) group.
- the present invention further comprises unsymmetrical di-ester derivatives of the compounds of Formula I, wherein Ri and R 2 are two different substituents.
- the invention relates to compounds of Formula I wherein R 3 is selected from the group consisting of hydrogen, methyl, ethyl and n-propyl and at least one of Ri and R 2 is Ci -6 alkanoyl, or at least one of Ri and R 2 is benzoyl, or at least one of Ri and R 2 is phenylacetyl.
- the invention furthermore relates to substantially pure tr ⁇ ns-diastereoisomers of Formula I wherein R 3 is selected from the group consisting of hydrogen, methyl, ethyl and n-propyl and at least one of Ri and R 2 is C 1-6 alkanoyl such as pivaloyl, or at least one of Ri and R 2 is benzoyl, or at least one of Ri and R 2 is phenylacetyl.
- the invention also relates to substantially pure (4aR,10aR) enantiomers of Formula I wherein R 3 is selected from the group consisting of hydrogen, methyl, ethyl and n -propyl and at least one of Ri and R 2 is C 1-6 alkanoyl such as pivaloyl, or at least one of Ri and R 2 is benzoyl, or at least one of Ri and R 2 is phenylacetyl.
- the compound of Formula (I) when specifying the compound of Formula (I) to be substantially enantiomerically or diastereomerically pure, then the compound is relatively stereochemically pure, preferably the enantiomeric or diastereomeric excess is at least 60%, at least 70%, and more preferably at least 80% (80% enantiomeric excess means that the ratio of eg. (4aR,10aR) to (4aS,10aS) is 90:10 in the mixture in question), at least 90%, at least 96%, or preferably at least 98%.
- Method 14 API 150EX and Shimadzu LC8/SLC-10A LC system. Column: C-18 4.6x30mm, 3.5 ⁇ m (Symmetry, Waters). Column temperature: rt. Gradient: reverse phase with ion pairing. Flow: 2mL/min. Injection volume: 10 micro-L. Gradient: 10% B in A to 100% B over 4 min then 10% B in A for 1 min. Total run time: 5 min.
- Method 17 API 150EX and Shimadzu LC8/SLC-10A LC system. Column: C- 18 4.6x30mm, 4 ⁇ m (Phenomenex Synergi Hydro). Temperature: rt. Gradient: reverse phase with ion pairing. Flow: 2mL/min. Injection volume: 10 micro-L. Gradient: 2% B in A to 100% B over 4 min then 10% B in A for 1 min. Total run time: 5 min.
- Method 25 API 150EX and Shimadzu LCIOAD/SLC-IOA LC system.
- Method 101 API 150EX and Shimadzu LC8/SLC-10A LC system.
- Method 102 API 150EX and Shimadzu LC8/SLC-10A LC system.
- Method 111 API 150EX and Shimadzu LC8/SLC-10A LC system.
- Method 314 API 150EX and Shimadzu LC8/SLC-10A LC system. Column: C-18 4.6 x 30mm, 3.5 ⁇ m (Symmetry, Waters). Column Temperature: rt. Flow 2 mL/min. Injection volume: 10 micro-L. Gradient: 10% B in A over 4 min then 100% B for 0.1 min then 10% B for A in 0.9 min. Total run time: 5.0 min.
- Method 23 SUN: API 150EX and Shimadzu LC8/SLC-10A LC system. Column: C- 18 4.6x30mm, 3.5 ⁇ m (Sunfire, Waters). Column temperature: 40 0 C. Gradient, reverse phase with ion pairing. Flow: 3.3 mL/min. Injection volume: 15 micro-L. Gradient: 10% B in A to 100% B over 2.4 min then 10% B in A for 0.4 min. Total run time: 2.8 min.
- Preparative LC/MS-purification was performed on the same instrument with atmospheric pressure chemical ionisation. Column: 50 x 20 mm YMC ODS-A with 5 ⁇ m particle size. Method: linear gradient elution with 80% A to 100% B in 7 min and with a flow rate of 22.7 mL/min. Fraction collection was performed by split-flow MS detection.
- sica gel chromatography (EtOAc/heptane) has the following meaning:
- the compound to be purified was usually dissolved in a small amount of DCM and loaded onto a column pre-packed with silica gel and eluted using a mixture of EtOAc and heptane, either in a isocratic fashion or with a gradient such as 0-100% of EtOAc in heptane.
- a column loaded with silica gel used is "ISOLUTE SPE COLUMNS" [e.g. 2Og FLASH Si 70 ml from International sorbent technology].
- classical manual chromatographic purifications were performed using silica gel [e.g. Machery-Nagel 60 M; 0.04-0.063 mm,
- Microwave-accelerated reactions were performed in sealed microwave reactor vials. The experiments were performed on a Smith Synthesizer from Personal Chemistry.
- lyophilized refers to the freeze-drying of a material using a Christ Aplha 2-4 LSC instrument from WWR International.
- dried (Na 2 SO 4 ) and “dried (Mg 2 SO 4 )” refers to the removal of water from organic layers by the addition of dry Na 2 SO 4 or Mg 2 SO 4 , respectively, followed by stirring for an appropriate amount of time to ensure an effective drying process. Then the solid is removed by filtration, and the filtrate is typically concentrated in vacuo (see below).
- the term "concentrated in vacuo” has the following meaning: The volatiles were removed from the mixture using a standard rotary evaporator at reduced pressure.
- the term “dried in vacuo at 40 0 C” refers to the use of a standard vacuum oven heated to 40 0 C connected to an oil pump.
- the term “dried in vacuo”” refers to a drying process in which the material to be dried is placed in a flask connected directly to an oil pump for a sufficient period of time to remove volatile components.
- X-ray crystal structure determinations were performed as follows.
- the crystal of the compounds was cooled to 120 K using a Cryostream nitrogen gas cooler system.
- the data were collected on a Siemens SMART Platform diffractometer with a CCD area sensitive detector.
- the structures were solved by direct methods and refined by full-matrix least- squares against F of all data.
- the hydrogen atoms in the structures could be found in the electron density difference maps.
- the Flack x-parameters are in the range 0.0(I)-0.05(1), indicating that the absolute structures are correct.
- Programs used for data collection, data reduction and absorption were SMART, SAINT and SADABS [cf. "SMART and SAINT, Area Detector Control and Integration Software", Version 5.054,Bruker Analytical X-Ray Instruments Inc., Madison, USA (1998), Sheldrick “SADABS, Program for Empirical Correction of Area Detector Data” Version 2.03, University of Gottingen, Germany (2001)].
- SHELXTL [cf.
- tr ⁇ ns-Markush Ib under the conditions described herein for the conversion of intermediate II to example 2gl to give tr ⁇ ns-Markush Ib. Further reaction with CH 2 ClBr or a related reagent in the presence of base can be applied to give tr ⁇ ns-Markush Ib-MDO e.g. under the conditions described herein for the synthesis of example 3bl. The resulting tr ⁇ ns-Markush Ib-MDO can be converted back to tr ⁇ ns-Markush Ib by treatment with BCl3/(n-Butyl)4NI or a related reagent.
- An alternative strategy involves acylation of intermediate II to tr ⁇ ns-Markush lb-2 which can be reduced to tr ⁇ ns-Markush Ib-I with LAH or a related reagent e.g. under the conditions described herein for the synthesis of example 2el to target trans-Markush Ib and tr ⁇ ns-Markush Ib-MDO analogs in which R 3 can be defined as CH 2 R.
- Treatment of tr ⁇ ns-Markush Ib with the appropriate acid chloride(s) in TFA can be used to prepare tr ⁇ ns-Markush lb-di-ester e.g. as described herein for the synthesis of example 4al.
- di-esters tr ⁇ ns-Markush lb-di-ester can be hydro lyzed to the parent catecholamines tr ⁇ ns-Markush Ib.
- tr ⁇ ns-Markush Ib-I is transformed to tr ⁇ ns-Markush Ib, tr ⁇ ns- Markush Ib-MDO, or tr ⁇ ns-Markush lb-di-ester as described before.
- tr ⁇ ns-Markush Ib- MDO treatment with e.g. BCl 3 /(n-Butyl)4NI can be used to give tr ⁇ ns-Markush Ib.
- treatment with e.g. Pd/C and hydrogen gas can be used to obtain czs-Markush lb-7.
- Cleavage of the amide group can afford czs-Markush lb-8.
- Direct 7V-alkylation e.g. under the conditions described herein for the conversion of intermediate II to example 2fl or reductive amination e.g. under the conditions described herein for the conversion of intermediate II to example 2hl can be used to obtain czs-Markush Ib-MDO.
- BCl 3 /(n-Butyl)4NI can be used to give czs-Markush Ib, which can be converted back to czs-Markush Ib-MDO by reaction with CH 2 ClBr or a related reagent in the presence of base to give czs-Markush Ib-MDO e.g. under the conditions described herein for the synthesis of example 3b 1.
- Treatment of czs-Markush Ib material with the appropriate acid chloride(s) in TFA can be used to prepare czs-Markush lb-di-ester e.g. as described herein for the synthesis of example 4al.
- di-esters can be hydro lyzed to the parent catecholamines czs-Markush Ib.
- Reduction of czs-Markush lb-8 can be used to prepare czs-Markush Ib-MDO analogs in which R 3 can be defined as CH 2 R 4 as described herein.
- KMnO 4 (4.75 g) was added to a stirred solution Of NaIO 4 (98 g) in water (1.7 L) at rt. The solution was stirred for 0.5h after which K 2 CO 3 (12.7 g) and the solution was stirred for an additional 5 min. A solution of compound 3 (14.8 g) in t-butyl alcohol (500 mL) was added. The solution was stirred 3h and then cooled on an ice/water bath. Sodium hydrogen sulfite (38-40% aqueous solution) was added drop-wise over 0.5h. DCM (1 L) was added and the layers were separated.
- the two enantiomers are then deprotected, and the nitrogen atom is functionalized using either by direct alkylation, reductive animation, or a two-step acylation/reduction. Finally, the masked catecholamine is liberated under standard conditions by treatment with 48% HBr or with BBr 3 .
- example 2d2 The absolute configuration of example 2d2 was determined by X-ray crystallography and allowed for unambiguous determination of the stereochemistry of intermediates II and III and hence their derivatives.
- MDO methylene-di-oxy
- Gensler, Samour J. Org. Chem., 18(1), 9, (1953); Cabiddu, Cadoni, De Montis, Fattuoni, Melis, Usai; Tetrahedron, 59(24), 4383 (2003); for references with catecholamines, see: Ram, Neumeyer; J. Org. Chem., 46(13), 2830 (1981); Nichols, Brewster, Johnson, Oberlender, Riggs; J. Med. Chem., 33(2), 703 (1990)].
- the catechol amine hydrobromide is treated with acylchloride using TFA as solvent.
- the crude diacyl catecholamines is purified by aluminium oxide chromatography [for a reference on this transformation, see for example: Wikstrom, Dijkstra, Cremers, Andren, Marchais, Jurva; WO 02/14279 Al, New aporphine esters and their use in therapy]. Preparation of compounds 12-17.
- the reaction mixture was quenched by adding 2M aqueous HCl (3 mL). Most of the volatiles were removed by concentration in vacuo and the residue was extracted with Et 2 O. The organic layer was extracted with more dilute HCl. The combined dilute HCl layers were basified with 9 M NaOH and then extracted with Et 2 O. The organic layer was washed with brine, dried (Na 2 SO 4 ) and concentrated in vacuo. The crude mixture was purified by silica gel chromatography (MeOH/EtOAc). Yield: 4 mg of compound 13 as an oil (slow eluting isomer), and 32 mg of compound 14 as an oil (fast eluting isomer).
- compound 22 compound 23 compound 24 compound 25 (racemate) (racemic mixture (racemic mixture (racemic mixture ofdiastereomers) of diastereomers) of diastereomers) 5-(4,4,5,5-Tetramethyl-[l,3,2]dioxaborolan-2-ylmethyl)-benzo[l,3]dioxole (compound 19).
- the crude intermediate was purified by silica gel chromatography (MeOH/EtOAc/Et 3 N) to give 78 mg of an oil.
- This material was placed in a microwave reactor vial and 48% HBr (2 mL) was added. The vial was sealed, and the mixture was stirred at 150 0 C for 0.5h under microwave irradiation.
- the reaction vessel was cooled to rt and a brown solid precipitated.
- the crude product was suspended in EtOH (1 mL) in a microwave reactor vial. The reactor was sealed, and the mixture was stirred at 90 0 C for 5 min under microwave irradiation.
- example 2d2 was dissolved in MeOH and allowed to crystallize slowly at rt over 2 months. The formed white crystals were collected and subjected to X-ray analysis (cf. Figure 2). 2el (4aR, 1 OaR)-I -(2-Hydroxy-ethyl)-l , 2, 3, 4, 4a, 5,10,1 Oa-octahydro-benzo[g]quinoline- 6, 7-diol trifluoroacetate
- Example 2b 1 (700 mg), Cs 2 CO 3 (1.7 g), CH 2 BrCl (0.22 mL) and DMF (5 mL) were heated to 110 0 C for 0.5h in a sealed microwave reactor vial under microwave irradiation.
- the crude mixture was purified by passing it through a plug of silica gel (MeOH/DCM). Yield of example 3bl: 7 mg as a solid.
- Example 2cl (475 mg), Cs 2 CO 3 (1.2 g), CH 2 BrCl (0.15 mL), and DMF (5 mL) were heated to 110 0 C for 0.5h in a sealed microwave reactor vial under microwave irradiation.
- the crude mixture was purified by passing it through a plug of silica gel (MeOH/DCM). The isolated material was dissolved in MeOH and 2 M HCl in Et 2 O was added followed by Et 2 O. The precipitated product was isolated by filtration and dried in vacuo. Yield of example 3cl: 15 mg as a solid.
- LC/MS (method 23). RT 0.87 min. ELSD 94.8%. UV 90.9%. MH + : 260.0.
- Example 2dl (7.80 g), Cs 2 CO 3 (18.6 g), CH 2 BrCl (2.2 mL), and DMF (180 mL) were heated to 100 0 C for Ih under an argon atmosphere.
- the crude reaction mixture was added to separatory funnel and diluted with ice/water (300 mL).
- the resulting mixture was extracted with Et 2 O (3x300 mL).
- the combined organic layers were washed with brine (200 mL), dried (MgSO 4 ) and concentrated in vacuo.
- Example 2b2 (18 mg) was treated with AcCl (56 micro-L) in TFA (0.5 mL) at rt for ⁇ lh. The crude mixture was concentrated in vacuo. The residue was purified by preparative LC/MS. Fractions containing example 4b2 were pooled, the acetonitrile was removed by concentration in vacuo, and the aqueous residue was lyophilized in vacuo to give the product. Yield of example 4b2: 6 mg as a white solid. LC/MS (method 14): RT 1.33 min, ELSD 99.8%, UV 93.7%. MH + : 318.0.
- Example 4dl was prepared in a similar manner as example 4bl starting from example 2dl (44 mg). Yield of example 4dl: 14 mg as a white solid. LC/MS (method 14): RT 2.45 min, ELSD 97.7%, UV 83.9%. MH + : 430.2.
- AcCl acetyl chloride (e.g. Aldrich 23,957-7).
- ACh acetylcholine.
- AcOH acetic acid.
- AD Alzheimer's disease.
- ADME absorption-distribution-metabolism-excretion. Allyl bromide (e.g. Fluka 05870)
- AlCl 3 aluminium chloride (e.g. Aldrich 29,471-3).
- CC D specific optical rotation.
- BBr 3 boron tribromide (used as DCM solution; Aldrich 17,893-4).
- BoC 2 O Boc anhydride / di-t-butyl dicarbonate (e.g. Aldrich 19,913-3).
- Brine saturated aqueous solution of sodium chloride.
- BSA bovine serum albumin. (s-Butyl)lithium (used as a cyc/o-hexane solution; e.g. Aldrich 19,559-6).
- cAMP cyclic adenosine monophosphate.
- Celite filter- aid.
- CH 2 BrCl bromochloromethane (Aldrich 13,526-7).
- CH 3 I methyl iodide / iodomethane (e.g. Aldrich 28,956-6).
- CHO cell Chinese hamster ovary cell.
- ClAcCl chloroacethyl chloride (e.g. Aldrich 10,449-3).
- Cs 2 CO 3 cesium carbonate (Aldrich 441902).
- CuI copper(I)iodide (Aldrich 215554). Cyclobutanone (e.g. Aldrich C9,600-l). cyc/o-propyl methyl bromide/(bromomethyl)-cyc/o-propane (Aldrich 24,240-3).
- DA dopamine.
- Dl dopamine Dl receptor.
- D2 dopamine D2 receptor.
- D3 dopamine D3 receptor.
- D4 dopamine D4 receptor.
- D5 dopamine D5 receptor.
- DCM dichloromethane / methylene chloride. l,6-dibromo-2-naphthol (e.g. Aldrich D4, 180-5).
- DMF dimethyl formamide.
- DMSO dimethyl sulfoxide.
- L-DOPA (levo)-3,4-dihydroxy phenylalanine.
- DOPAC 3,4- dihydroxyphenyl acetic acid (DA metabolite).
- EC50 concentration required to induce a response halfway between the baseline and the maximum response for the compound in question.
- ELSD evaporative light scattering detection.
- Et 3 N triethyl amine.
- Et 2 NH diethyl amine.
- EtOAc ethyl acetate.
- Ethyl magnesium bromide (used as a 3 M solution in Et 2 O; Aldrich 18,987-1).
- Et 2 O diethyl ether. [(l-Ethoxycyclopropyl)-oxy]trimethylsilane (Aldrich 332739).
- FLIPR fluorometric imaging plate reader.
- HCl 18% / 37% aqueous solution of hydrogen chloride.
- 1 M HCl / 2 M HCl 1 M / 2 M aqueous solution of hydrogen chloride (unless noted specifically as a 2M Et 2 O solution, which is commercially available, e.g. Aldrich 45,518-0).
- HMPA hexamethylphosphorous triamide.
- HVA homovanillic acid (DA metabolite).
- i iso.
- 1-Iodopropane e.g. Aldrich 17,188-3).
- K 2 CO 3 potassium carbonate (e.g.
- LDA lithium di-z-propylamide (used as a THF/heptane/ethylbenzene solution; Fluka 62491).
- LC/MS high-performance liquid chromatography / mass spectrometer.
- LAH lithium aluminium hydride (used as a IM THF solution; Aldrich 21,277-6).
- LiCl lithium chloride (e.g. Aldrich 31,046-8).
- L-Selectride lithium tri-s-butylborohydride (used as a IM THF solution; Aldrich 17,849-7).
- MDO methylene-di-oxy.
- MED minimal effective dose.
- MEDNemonap ⁇ de minimal effective dose in the presence of Nemonapride.
- MBD minimal brain dysfunction.
- 2-Methyl-THF e.g. Aldrich 41,424-7.
- MPTP l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine.
- NaCNBH 3 sodium cyanoborohydride (Aldrich 15,615-9).
- Na 2 S 2 O 3 Sodium bisulfite (used as an 38-40% aqueous solution; eg. Riedel 13438).
- NaH sodium hydride (used as a 60% dispersion; Aldrich 45,291-2).
- NaIO 4 sodium periodate (e.g. Aldrich 31,144-8).
- 1 M / 9 M NaOH 1 M / 9 M aqueous solution of sodium hydroxide.
- NaOMe sodium methoxide (used as a ca. 5 M solution in methanol; e.g. Aldrich 15,625-6).
- NPA TV-n-propyl Apomorphine.
- 6-OHDA 6-hydroxydopamine.
- PBS phosphate buffered saline (0.02 M sodium phosphate buffer with 0.15 M sodium chloride, pH adjusted to 7.4).
- PD Parkinson's disease.
- PFC prefrontal cortex.
- Pd/C palladium-on-charcoal (e.g. Aldrich 20,569-9).
- Pd(OAc) 2 palladium(II)acetate (Alfa Aesar 010516). Piperonyl alcohol (e.g. Aldrich P4, 940-6).
- PK pharmaco-kinetic.
- PLMD periodic limb movement disorder.
- Propargyl chloride e.g. Aldrich 14,399-5).
- Propionaldehyde e.g. Aldrich 58,812-4).
- PTSA /? ⁇ r ⁇ -toluene sulfonic acid hydrate (e.g. Aldrich 40,288-5).
- PivCl pivaloyl chloride / trimethyl acetyl chloride (e.g. Aldrich T7,260-5).
- SC subcutaneous.
- SFC supercritical flash chromatography. Sodium metal (e.g. Aldrich 28,205-7).
- t tertiary.
- TBAI tetra-n-butyl ammonium iodide (e.g. Aldrich 14,077-5).
- TFA trifluoroacetic acid.
- TFAA trifluoroacetatic acid anhydride.
- THF tetrahydrofuran (dried over 4A molecular sieves).
- TLC thin layer chromatography.
- CH(OCHs) 3 trimethyl orthoformate (e.g. Aldrich 30,547-2).
- UV ultraviolet purity (at 254 nm unless noted differently).
- the ability of the compounds to either stimulate or inhibit the Dl receptor mediated cAMP formation in CHO cells stably expressing the human recombinant Dl receptor was measured as follows. Cells were seeded in 96-well plates at a concentration of 11000 cells/well 3 days prior to the experiment.
- the cells were incubated for 20 minutes at 37 °C and the reaction was stopped by the addition of 100 micro-L S buffer (0.1 M HCl and 0.1 mM CaCl 2 ) and the plates were placed at 4 °C for Ih. 68 micro-L N buffer (0.15 M NaOH and 60 mM NaOAc) was added and the plates were shaken for 10 minutes.
- 100 micro-L S buffer 0.1 M HCl and 0.1 mM CaCl 2
- 68 micro-L N buffer (0.15 M NaOH and 60 mM NaOAc
- 60 micro-1 of the reaction were transferred to cAMP FlashPlates (DuPont NEN) containing 40 micro-L 60 mM Sodium acetate pH 6.2 and 100 micro-L IC mix (50 mM Sodium acetate pH 6.2, 0.1 % sodium azide, 12 mM CaCl 2 , 1% BSA (bovine serum albumin) and 0.15 micro-Ci/mL 125 I-cAMP) were added. Following an 18h incubation at 4 °C the plates were washed once and counted in a Wallac TriLux counter.
- the ability of the compounds to either stimulate or inhibit the D2 receptor mediated inhibition of cAMP formation in CHO cells transfected with the human D2 receptor was measure as follows. Cells were seeded in 96 well plates at a concentration of 8000 cells/well 3 days prior to the experiment. On the day of the experiment the cells were washed once in preheated G buffer (1 mM MgCl 2 , 0.9 mM CaCl 2 , 1 mM IBMX in PBS) and the assay was initiated by addition of 100 micro-1 of a mixture of 1 micro-M quinpirole, 10 microM forskolin and test compound in G buffer (antagonism) or 10 micro-M forskolin and test compound in G buffer (agonism).
- the cells were incubated 20 minutes at 37 °C and the reaction was stopped by the addition of 100 micro-1 S buffer (0.1 M HCl and 0.1 mM CaCl 2 ) and the plates were placed at 4 °C for Ih. 68 micro-L N buffer (0.15 M NaOH and 60 mM Sodium acetate) were added and the plates were shaken for 10 minutes.
- 100 micro-1 S buffer 0.1 M HCl and 0.1 mM CaCl 2
- 68 micro-L N buffer (0.15 M NaOH and 60 mM Sodium acetate
- 60 micro-L of the reaction were transferred to cAMP FlashPlates (DuPont NEN) containing 40 micro-L 60 mM NaOAc pH 6.2 and 100 micro-L IC mix (50 mM NaOAc pH 6.2, 0.1 % Sodium azide, 12 mM CaCl 2 , 1% BSA and 0.15 micro- Ci/ml 125 I-cAMP) were added. Following an 18h incubation at 4 °C the plates were washed once and counted in a Wallac TriLux counter.
- Dopamine agonists can have activity at either the Dl -like receptors, the D2-like receptors, or both.
- MED minimum effective dose
- a second experiment is performed to determine the MED of the compound to overcome Nemonapride block (MED N emonap ⁇ de).
- Nemonapride is a D2-like antagonist that blocks the D2-like receptor, therefore any observed rotations would be dependent upon activity at the Dl -like receptor.
- a third experiment is run using the MEDNemonap ⁇ de dose and observing the effect of the Dl -like antagonist, SCH 23390 alone, the D2-like antagonist, Nemonapride alone and finally, the effect of combined treatment with SCH 23390 and Nemonapride.
- the dyskinetic profile of some of the compounds of the invention was studied using an animal model described in the literature [Lundblad, Andersson, Winkler, Kirik, Wierup, Cenci; Eur. J. Neurosci., 15(1), 120 (2002)]. In this paradigm some of the compounds of the invention gave less dyskinesias than L-DOPA or Apomorhine in drug-naive animals. Some of the compounds of the invention further reduced L-DOPA induced dyskinesias significantly more than was observed when shifting animals from L-DOPA to Pramipexole.
- Human D5 (hD5) expression construct was made using a modified pEXJ vector.
- a stable cell line expressing a promiscuous human Galphal ⁇ G protein (CHO-GaI 6) was purchased from (Molecular Devices, Sunnyvale, CA). The cells were cultured in HAMS F- 12 media (Invitrogen, Carlsbad, CA) containing 10% FSB (foelal bovine serum), 1% L-glutamine and 1% penicillin/streptomycin (P/S) at 37 °C in 5% CO 2 .
- CHO-GaI 6 cells were transiently transfected with hD5 receptor DNA using a lipofectamine Plus method (Invitrogen, Carlsbad, CA), and allow to grow for 1 day in serum and P/S free media.
- hD5 transfected CHO-GaI 6 cells were seeded at a density of 10,000 cells per well into black walled clear-base 384-well plates pretreated with poly-D-Lysine (Becton Dickinson, USA). The cells were then cultured in HAMS F-12 cell growth media containing 1.5% FBS, 1% L-glutamine and 1% penicillin/streptomycin (P/S) at 37 °C in 5% CO 2
- the loading buffer contains IX HBSS
- the plates were incubated for Ih at 37 °C and 5% CO 2 and washed three times with washing buffer.
- the washing buffer contains the same components as the loading buffer excluding Fluo-4-AM.
- the cells were then placed into a fluorescence imager plate reader (FLIPRTM, Molecular
- Antagonist activities of compounds were assayed for their inhibition of the signal elicited by agonist ligands.
- Cells were pre-incubated with compounds at increasing concentrations, and then stimulated with agonists using the methods described above.
- Incubations were started after 15 min of pre-incubation and stopped at time points of 0, 5, 15, 30 and 60 min for rats and at 0, 30, 60, 90 and 120 min for human hepatocytes. Incubations were stopped by addition of an equal volumes of ice-cold acetonitrile containing 10% 1 M HCl. Following centrifugation, 20 micro-L of the supernatants were injected on a HPLC Column Atlantis dC18 3 micro-m, 150 x 2.1 mm i.d. (Waters, MA, USA). The mobile phase had the following composition: A: 5% acetonitrile, 95% H 2 O, 3.7 ml/1 25% aq. NH 3 , 1.8 mL/L formic acid.
- Mobile phase B 100% acetonitrile and 0.1% formic acid.
- the flow rate was 0.3 ml/min.
- the gradient operated from 0% to 75 % B from 5 min to 20 min and the eluate was analyzed using a Q-TOFmicro mass spectrometer (Waters, MA, USA). Formation of the product/metabolite was confirmed by accurate mass measurements and comparison with a synthesized standard giving coinciding retention times.
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EA200971107A EA018011B1 (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives useful for the treatment of parkinson's disease |
KR1020157026863A KR20150115963A (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives useful for the treatment of parkinson's disease |
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AU2008291425A AU2008291425B2 (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives useful for the treatment of Parkinson' s disease |
JP2010522186A JP5548125B2 (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives useful for the treatment of Parkinson's disease |
CN200880023124A CN101687878A (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives useful for the treatment of parkinson' s disease |
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BRPI0813456-1A2A BRPI0813456A2 (en) | 2007-08-31 | 2008-08-28 | COMPOSITION, USE OF THE SAME, PHARMACEUTICAL COMPOSITION, AND METHODS TO TREAT A MAMMAL WITH A DISORDER AND DISEASE |
SI200831554T SI2197883T1 (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivative useful for the treatment of parkinson's disease |
UAA201000849A UA97989C2 (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives useful for the treatment of parkinson' s disease |
CA2691961A CA2691961C (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives and prodrugs thereof |
ZA2009/09191A ZA200909191B (en) | 2007-08-31 | 2009-12-23 | Catecholamine derivatives useful for the treatment of parkinson's disease |
IL203080A IL203080A (en) | 2007-08-31 | 2009-12-31 | Catecholamine derivatives useful for the treatment of parkinson' s disease |
HRP20151334TT HRP20151334T1 (en) | 2007-08-31 | 2015-12-07 | Catecholamine derivative useful for the treatment of parkinson's |
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PCT/DK2008/050214 WO2009026934A1 (en) | 2007-08-31 | 2008-08-28 | Catecholamine derivatives useful for the treatment of parkinson' s disease |
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WO2009156458A1 (en) * | 2008-06-27 | 2009-12-30 | H. Lundbeck A/S | Novel phenolic and catecholic amines and prodrugs thereof |
WO2010097092A1 (en) * | 2009-02-27 | 2010-09-02 | H. Lundbeck A/S | Treatment of dyskinesia related disorders |
US8067410B2 (en) | 2008-06-27 | 2011-11-29 | H. Lundbeck A/S | Phenolic and catecholic amines and prodrugs thereof |
JP2014111635A (en) * | 2007-08-31 | 2014-06-19 | H Lundbeck As | Catecholamine derivative and prodrug of the same |
WO2019101917A1 (en) | 2017-11-24 | 2019-05-31 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
WO2020070099A1 (en) | 2018-10-02 | 2020-04-09 | H. Lundbeck A/S | Administration of catecholamine prodrugs in combination with a 5-ht2b antagonist |
WO2020234274A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
WO2020234276A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's disease |
WO2020234273A1 (en) | 2019-05-20 | 2020-11-26 | H. Lundbeck A/S | A process for the manufacturing of (6ar,10ar)-7-propyl-6,6a,7,8,9,10,10a,11-octahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-g]quinoline and (4ar,10ar)-1-propyl-1,2,3,4,4a,5,10,10a-octahydro-benzo[g]quinoline-6,7-diol |
WO2020234270A1 (en) | 2019-05-20 | 2020-11-26 | H. Lundbeck A/S | A process for the manufacture of (2s,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(((4ar,10ar)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2h-pyran-2-carboxylic acid and intermediate thereof |
WO2020234275A1 (en) | 2019-05-21 | 2020-11-26 | H. Lundbeck A/S | New catecholamine prodrugs for use in the treatment of parkinson's diseases |
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WO2020234271A1 (en) | 2019-05-20 | 2020-11-26 | H. Lundbeck A/S | A process for the manufacture of (2s,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(((4ar,10ar)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2h-pyran-2-carboxylic acid |
WO2020234272A1 (en) | 2019-05-20 | 2020-11-26 | H. Lundbeck A/S | New solid forms of (2s,3s,4s,5r,6s)-3,4,5-trihydroxy-6-(((4ar,10ar)-7-hydroxy-1-propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g]quinolin-6-yl)oxy)tetrahydro-2h-pyran-2-carboxylic acid |
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Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4080456A (en) * | 1971-10-26 | 1978-03-21 | Schering Aktiengesellschaft | Diacylapomorphines |
CH648300A5 (en) * | 1979-06-22 | 1985-03-15 | Sandoz Ag | Phenanthrene derivatives and medicaments containing them |
US4543256A (en) * | 1982-03-17 | 1985-09-24 | Northeastern University | (-)-10,1L Methylenedioxy-N-N-propylnoraporphine and methods employing it for inhibiting the effects of epileptic seizures and for prevention and treatment of duodenal ulcers |
WO1990012574A1 (en) * | 1989-04-25 | 1990-11-01 | Northeastern University | Dopamine agonist compounds |
DD299303A5 (en) * | 1989-08-30 | 1992-04-09 | ��@���������@�������k�� | INDOLOBENZOQUINOLINE DERIVATIVES, THEIR PREPARATION AND USE AS ANTIARRHYTHMIC MEDICAMENTS |
TW357143B (en) * | 1995-07-07 | 1999-05-01 | Novartis Ag | Benzo[g]quinoline derivatives |
AU7490496A (en) * | 1995-11-10 | 1997-05-29 | Novo Nordisk A/S | Enantiomers of cis-benz{e}indole compounds, their preparation and utility as dopamine-d3 receptor selective agents |
CN1241998A (en) * | 1996-10-30 | 2000-01-19 | 伊莱利利公司 | Synthesis of benzo (F) quinolinones |
SE0102036D0 (en) | 2001-06-08 | 2001-06-08 | Axon Biochemicals Bv | Pharmaceutical formulation for the efficient administration of apomorphine, 6aR- (-) -N- Propyl- norapomorphine and their derivatives and pro-drugs thereof |
SE0002934D0 (en) | 2000-08-17 | 2000-08-17 | Axon Biochemicals Bv | New aporphine esters and in their use in therapy |
AR030357A1 (en) * | 2000-08-18 | 2003-08-20 | Lundbeck & Co As H | DERIVATIVES 4 -, 5 -, 6 - AND 7-INDOL |
US20050090518A1 (en) * | 2003-10-24 | 2005-04-28 | Nastech Pharmaceutical Company Inc. | Method for treating parkinson's disease using apomorphine and apomorphine prodrugs |
TWI404702B (en) * | 2007-08-31 | 2013-08-11 | Lundbeck & Co As H | Catecholamine derivatives and prodrugs thereof |
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Non-Patent Citations (1)
Title |
---|
LIU ET AL: "A novel synthesis and pharmacological evaluation of a potential dopamine D1/D2 agonist: 1-Propyl-1,2,3,4,4a,5,10,10a-octahydrobenzo[g ]quinoline-6,7-diol", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 16, no. 6, 23 June 2007 (2007-06-23), pages 3438 - 3444, XP022558577, ISSN: 0968-0896 * |
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