WO2009024620A2 - A process for isolation and purification of a target protein free of prion protein (prpsc) - Google Patents
A process for isolation and purification of a target protein free of prion protein (prpsc) Download PDFInfo
- Publication number
- WO2009024620A2 WO2009024620A2 PCT/EP2008/061068 EP2008061068W WO2009024620A2 WO 2009024620 A2 WO2009024620 A2 WO 2009024620A2 EP 2008061068 W EP2008061068 W EP 2008061068W WO 2009024620 A2 WO2009024620 A2 WO 2009024620A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protein
- employing
- buffer
- wash buffer
- buffer containing
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3804—Affinity chromatography
- B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
- B01D15/424—Elution mode
- B01D15/426—Specific type of solvent
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/12—Purification
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
- B01D15/3847—Multimodal interactions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7151—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for tumor necrosis factor [TNF], for lymphotoxin [LT]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims
Priority Applications (13)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/733,306 US9296799B2 (en) | 2007-08-23 | 2008-08-25 | Process for isolation and purification of a target protein free of prion protein (PrPSC) |
BRPI0815758-8A BRPI0815758B1 (en) | 2007-08-23 | 2008-08-25 | PROCESS FOR THE INSULATION AND PURIFICATION OF A PRION PROTEIN FREE TARGET PROTEIN (PrPsc) |
ES08787446T ES2572352T3 (en) | 2007-08-23 | 2008-08-25 | Isolation and purification procedure for prion protein-free target protein (PrPSC) |
CA2696865A CA2696865C (en) | 2007-08-23 | 2008-08-25 | A process for isolation and purification of a target protein free of prion protein (prpsc) |
DK08787446.7T DK2190486T3 (en) | 2007-08-23 | 2008-08-25 | Method for Isolating and Purifying a Target Protein Free of Prion Protein (prpsc) |
MX2010001919A MX2010001919A (en) | 2007-08-23 | 2008-08-25 | A process for isolation and purification of a target protein free of prion protein (prpsc). |
RU2010110805/10A RU2491292C2 (en) | 2007-08-23 | 2008-08-25 | METHOD OF SEPARATING AND PURIFYING TARGET PROTEIN WITHOUT ADMIXTURE OF PRION PROTEIN PrPsc |
EP08787446.7A EP2190486B1 (en) | 2007-08-23 | 2008-08-25 | A process for isolation and purification of a target protein free of prion protein (prpsc) |
JP2010521447A JP5797404B2 (en) | 2007-08-23 | 2008-08-25 | Method for isolation and purification of target protein not containing prion protein (PrPsc) |
AU2008290482A AU2008290482B2 (en) | 2007-08-23 | 2008-08-25 | A process for isolation and purification of a target protein free of prion protein (PrPSC) |
CN200880104009XA CN101842121B (en) | 2007-08-23 | 2008-08-25 | Process for isolation and purification of target protein free of prion protein (PrPSC) |
IL203573A IL203573A (en) | 2007-08-23 | 2010-01-28 | Process for isolation and purification of a target protein free of prion protein (prpsc) |
US14/982,148 US20160152661A1 (en) | 2007-08-23 | 2015-12-29 | Process for isolation and purification of a target protein free of prion protein (prpsc) |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP07114856A EP2027875A1 (en) | 2007-08-23 | 2007-08-23 | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
EP07114856.3 | 2007-08-23 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/733,306 A-371-Of-International US9296799B2 (en) | 2007-08-23 | 2008-08-25 | Process for isolation and purification of a target protein free of prion protein (PrPSC) |
US14/982,148 Division US20160152661A1 (en) | 2007-08-23 | 2015-12-29 | Process for isolation and purification of a target protein free of prion protein (prpsc) |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009024620A2 true WO2009024620A2 (en) | 2009-02-26 |
WO2009024620A3 WO2009024620A3 (en) | 2009-04-23 |
Family
ID=38720286
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2008/061068 WO2009024620A2 (en) | 2007-08-23 | 2008-08-25 | A process for isolation and purification of a target protein free of prion protein (prpsc) |
Country Status (16)
Country | Link |
---|---|
US (2) | US9296799B2 (en) |
EP (3) | EP2027875A1 (en) |
JP (1) | JP5797404B2 (en) |
KR (1) | KR20100057614A (en) |
CN (1) | CN101842121B (en) |
AU (1) | AU2008290482B2 (en) |
BR (1) | BRPI0815758B1 (en) |
CA (1) | CA2696865C (en) |
DK (2) | DK3034097T3 (en) |
ES (2) | ES2671026T3 (en) |
IL (1) | IL203573A (en) |
MX (1) | MX2010001919A (en) |
RU (1) | RU2491292C2 (en) |
TR (1) | TR201807044T4 (en) |
WO (1) | WO2009024620A2 (en) |
ZA (1) | ZA201001246B (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011121020A1 (en) | 2010-03-30 | 2011-10-06 | Octapharma Ag | A process for purifying vitamin k dependent proteins such as coagulation factor ix |
JP2014502259A (en) * | 2010-11-05 | 2014-01-30 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Method for optimizing antibody capture by mixed-mode chromatography |
EP2727930A1 (en) * | 2011-06-29 | 2014-05-07 | Kyowa Hakko Kirin Co., Ltd. | Method for purifying protein |
US9453045B2 (en) | 2010-03-30 | 2016-09-27 | Octapharma Ag | Process for the purification of a growth factor protein |
US9488625B2 (en) | 2010-12-15 | 2016-11-08 | Baxalta GmbH | Purification of factor VIII using a conductivity gradient |
WO2016207328A1 (en) * | 2015-06-24 | 2016-12-29 | Glycotope Gmbh | PROCESS FOR THE PURIFICATION OF γ-CARBOXYLATED POLYPEPTIDES |
US10188965B2 (en) | 2012-12-05 | 2019-01-29 | Csl Behring Gmbh | Hydrophobic charge induction chromatographic depletion of a protein from a solution |
US10792353B2 (en) | 2007-03-14 | 2020-10-06 | Takeda Vaccines, Inc. | Virus like particle purification |
US11091519B2 (en) | 2012-06-22 | 2021-08-17 | Takeda Vaccines, Inc. | Purification of virus like particles |
US11426680B2 (en) | 2012-12-05 | 2022-08-30 | Csl Behring Gmbh | Hydrophobic charge induction chromatographic protein depleted solution |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008008872A2 (en) | 2006-07-14 | 2008-01-17 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
EP2027875A1 (en) * | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
US20120183527A1 (en) * | 2011-01-18 | 2012-07-19 | Baxter International Inc. | Measurement of anti-amyloid antibodies in human blood |
AU2012213432B2 (en) * | 2011-02-01 | 2016-10-13 | Novo Nordisk A/S | Purification of insulin |
CN102675414A (en) * | 2011-03-08 | 2012-09-19 | 上海天伟生物制药有限公司 | Method for removing/inactivating prion in glycoprotein |
KR102125695B1 (en) * | 2012-10-03 | 2020-06-24 | 체에스엘 베링 아게 | A method of purifying proteins |
CN103336124B (en) * | 2012-12-11 | 2015-07-15 | 武汉工业学院 | Method and kit for detecting prion protein (PrP<SC>) |
EP3160611A4 (en) * | 2014-06-25 | 2018-02-28 | JHL Biotech, Inc. | Methods and reagents for purification of proteins |
DE102016004432A1 (en) * | 2016-04-12 | 2017-10-12 | Sartorius Stedim Biotech Gmbh | Multimodal adsorption medium with multimodal ligands, process for its preparation and its use |
CN110314414B (en) * | 2019-07-23 | 2021-10-19 | 宝锐生物科技泰州有限公司 | Separation and purification method of blood coagulation factor XIII and application thereof |
CN112409476B (en) * | 2020-08-13 | 2022-03-29 | 中元汇吉生物技术股份有限公司 | Purification method of four blood-derived proteins |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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WO1994008686A1 (en) * | 1992-10-21 | 1994-04-28 | Cornell Research Foundation, Inc. | Multimodal chromatographic separation media and process for usingsame |
WO1998000441A1 (en) * | 1996-07-01 | 1998-01-08 | Biopure Corporation | A method for chromatographic removal of prions |
WO2003105911A1 (en) * | 2002-06-18 | 2003-12-24 | Common Services Agency | Removal of prion infectivity |
WO2004024318A1 (en) * | 2002-09-13 | 2004-03-25 | Pall Corporation | Preparation and use of mixed mode solid substrates for chromatography adsorbents and biochip arrays |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5234991A (en) | 1975-07-29 | 1993-08-10 | Pasteur Merieux Serums And Vaccines | Porous mineral support coated with an aminated polysaccharide polymer |
FR2616437B1 (en) | 1987-06-11 | 1990-09-07 | Ibf | COMPOSITE POLYMERS, THEIR PREPARATION AND THEIR USE IN LIQUID CHROMATOGRAPHY |
US5268097A (en) | 1992-06-19 | 1993-12-07 | Sepracor Inc. | Passivated and stabilized porous mineral oxide supports and method for the preparation and use of same |
AT405119B (en) | 1996-06-28 | 1999-05-25 | Poschik Roland | DEVICE FOR ACTUATING THE SLIDER OF A ZIPPER AND ZIPPER |
WO2000043048A1 (en) * | 1999-01-19 | 2000-07-27 | Common Services Agency | Treating protein-containing liquids |
US7750129B2 (en) * | 2004-02-27 | 2010-07-06 | Ge Healthcare Bio-Sciences Ab | Process for the purification of antibodies |
SE0400501D0 (en) | 2004-02-27 | 2004-02-27 | Amersham Biosciences Ab | Antibody purification |
EP1707634A1 (en) * | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
EP2027875A1 (en) * | 2007-08-23 | 2009-02-25 | Octapharma AG | A Process for Isolation and Purification of a Target Protein free of Prion Protein (PrPSC) |
US8329871B2 (en) * | 2008-06-24 | 2012-12-11 | Octapharma Ag | Process of purifying coagulation factor VIII |
WO2011121031A1 (en) * | 2010-03-30 | 2011-10-06 | Octapharma Ag | Process for the purification of a growth factor protein |
-
2007
- 2007-08-23 EP EP07114856A patent/EP2027875A1/en not_active Ceased
-
2008
- 2008-08-25 RU RU2010110805/10A patent/RU2491292C2/en active
- 2008-08-25 TR TR2018/07044T patent/TR201807044T4/en unknown
- 2008-08-25 WO PCT/EP2008/061068 patent/WO2009024620A2/en active Application Filing
- 2008-08-25 DK DK15198333.5T patent/DK3034097T3/en active
- 2008-08-25 BR BRPI0815758-8A patent/BRPI0815758B1/en active IP Right Grant
- 2008-08-25 KR KR1020107003554A patent/KR20100057614A/en not_active Application Discontinuation
- 2008-08-25 JP JP2010521447A patent/JP5797404B2/en active Active
- 2008-08-25 MX MX2010001919A patent/MX2010001919A/en unknown
- 2008-08-25 DK DK08787446.7T patent/DK2190486T3/en active
- 2008-08-25 ES ES15198333.5T patent/ES2671026T3/en active Active
- 2008-08-25 CN CN200880104009XA patent/CN101842121B/en active Active
- 2008-08-25 EP EP15198333.5A patent/EP3034097B1/en active Active
- 2008-08-25 ES ES08787446T patent/ES2572352T3/en active Active
- 2008-08-25 US US12/733,306 patent/US9296799B2/en active Active
- 2008-08-25 AU AU2008290482A patent/AU2008290482B2/en active Active
- 2008-08-25 CA CA2696865A patent/CA2696865C/en active Active
- 2008-08-25 EP EP08787446.7A patent/EP2190486B1/en active Active
-
2010
- 2010-01-28 IL IL203573A patent/IL203573A/en active IP Right Grant
- 2010-02-22 ZA ZA201001246A patent/ZA201001246B/en unknown
-
2015
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US20100210821A1 (en) | 2010-08-19 |
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CA2696865A1 (en) | 2009-02-26 |
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KR20100057614A (en) | 2010-05-31 |
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US9296799B2 (en) | 2016-03-29 |
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US20160152661A1 (en) | 2016-06-02 |
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