WO2009013358A3 - Polysaccharides grafted by polyamines for the preparation of radiopharmaceutical compositions - Google Patents

Polysaccharides grafted by polyamines for the preparation of radiopharmaceutical compositions Download PDF

Info

Publication number
WO2009013358A3
WO2009013358A3 PCT/EP2008/059825 EP2008059825W WO2009013358A3 WO 2009013358 A3 WO2009013358 A3 WO 2009013358A3 EP 2008059825 W EP2008059825 W EP 2008059825W WO 2009013358 A3 WO2009013358 A3 WO 2009013358A3
Authority
WO
WIPO (PCT)
Prior art keywords
polyamines
preparation
radiopharmaceutical compositions
polysaccharides grafted
grafted
Prior art date
Application number
PCT/EP2008/059825
Other languages
French (fr)
Other versions
WO2009013358A2 (en
Inventor
Benoît DENIZOT
Franck Lacoeuille
Jean Jacques Le Jeune
François HINDRE
Original Assignee
Laboratoires Cyclopharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to MX2010001013A priority Critical patent/MX2010001013A/en
Priority to DK08775355.4T priority patent/DK2175888T3/en
Priority to US12/670,811 priority patent/US9023396B2/en
Priority to CN2008801043115A priority patent/CN101861171B/en
Priority to AU2008278976A priority patent/AU2008278976B2/en
Priority to EP08775355A priority patent/EP2175888B1/en
Priority to SI200830730T priority patent/SI2175888T1/en
Application filed by Laboratoires Cyclopharma filed Critical Laboratoires Cyclopharma
Priority to ES08775355T priority patent/ES2386849T3/en
Priority to CA2694582A priority patent/CA2694582C/en
Priority to JP2010517415A priority patent/JP5946241B2/en
Priority to RU2010107029/15A priority patent/RU2481856C2/en
Priority to RS20120299A priority patent/RS52405B/en
Priority to PL08775355T priority patent/PL2175888T3/en
Priority to BRPI0814470-2A priority patent/BRPI0814470B1/en
Publication of WO2009013358A2 publication Critical patent/WO2009013358A2/en
Publication of WO2009013358A3 publication Critical patent/WO2009013358A3/en
Priority to IL203512A priority patent/IL203512A/en
Priority to HK11103631.6A priority patent/HK1149211A1/en
Priority to HRP20120526AT priority patent/HRP20120526T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

The invention relates to new pharmaceutical compositions based on grafted polysaccharides and polyvalent metal complexing agents which are radioactive in particular and to the use thereof in medical imaging, specifically scintigraphy, and in internal radiotherapy.
PCT/EP2008/059825 2007-07-26 2008-07-25 New compositions based on polysaccharides grafted by polyamine or polysulphurised compounds WO2009013358A2 (en)

Priority Applications (17)

Application Number Priority Date Filing Date Title
PL08775355T PL2175888T3 (en) 2007-07-26 2008-07-25 Radiopharmaceutical compositions comprising polysaccharides grafted by polyamines
US12/670,811 US9023396B2 (en) 2007-07-26 2008-07-25 Compositions based on polysaccharides grafted by polyamine or polysulphurised compounds
CN2008801043115A CN101861171B (en) 2007-07-26 2008-07-25 Polysaccharides grafted by polyamine for preparing radioactive pharmaceutical composition
AU2008278976A AU2008278976B2 (en) 2007-07-26 2008-07-25 Polysaccharides grafted by polyamines for the preparation of radiopharmaceutical compositions
EP08775355A EP2175888B1 (en) 2007-07-26 2008-07-25 Radiopharmaceutical compositions comprising polysaccharides grafted by polyamines
SI200830730T SI2175888T1 (en) 2007-07-26 2008-07-25 Radiopharmaceutical compositions comprising polysaccharides grafted by polyamines
JP2010517415A JP5946241B2 (en) 2007-07-26 2008-07-25 Grafted polysaccharides with polyamines for the production of radiopharmaceutical compositions
ES08775355T ES2386849T3 (en) 2007-07-26 2008-07-25 Radiopharmaceutical compositions comprising polyamine grafted polysaccharides
CA2694582A CA2694582C (en) 2007-07-26 2008-07-25 New compositions based on polysaccharides grafted by polyamine or polysulphurised compounds
MX2010001013A MX2010001013A (en) 2007-07-26 2008-07-25 New compositions based on polysaccharides grafted by polyamine or polysulphurised compounds.
RU2010107029/15A RU2481856C2 (en) 2007-07-26 2008-07-25 New compositions of polysaccharides grafted by polyamine or polysulphonates compounds
RS20120299A RS52405B (en) 2007-07-26 2008-07-25 Radiopharmaceutical compositions comprising polysaccharides grafted by polyamines
DK08775355.4T DK2175888T3 (en) 2007-07-26 2008-07-25 RADIOPHARMACEUTICAL COMPOSITIONS INCLUDING POLYSACCHARIDS INGOED WITH POLYAMINES
BRPI0814470-2A BRPI0814470B1 (en) 2007-07-26 2008-07-25 PROCESS FOR PREPARING A COMPOSITION, COMPOSITION AND USING THE COMPOSITION
IL203512A IL203512A (en) 2007-07-26 2010-01-26 Compositions comprising polysacharides, processes for their preparation and uses thereof
HK11103631.6A HK1149211A1 (en) 2007-07-26 2011-04-11 Polysaccharides grafted by polyamines for the preparation of radiopharmaceutical compositions
HRP20120526AT HRP20120526T1 (en) 2007-07-26 2012-06-21 Radiopharmaceutical compositions comprising polysaccharides grafted by polyamines

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US95209407P 2007-07-26 2007-07-26
FR0756750A FR2919189A1 (en) 2007-07-26 2007-07-26 NOVEL COMPOSITIONS BASED ON POLYOSIDES GRAFTED BY POLYAMINE OR POLYSOUFRE COMPOUNDS.
FR0756750 2007-07-26
US60/952,094 2007-07-26

Publications (2)

Publication Number Publication Date
WO2009013358A2 WO2009013358A2 (en) 2009-01-29
WO2009013358A3 true WO2009013358A3 (en) 2009-10-22

Family

ID=38896852

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/059825 WO2009013358A2 (en) 2007-07-26 2008-07-25 New compositions based on polysaccharides grafted by polyamine or polysulphurised compounds

Country Status (22)

Country Link
US (1) US9023396B2 (en)
EP (1) EP2175888B1 (en)
JP (1) JP5946241B2 (en)
KR (1) KR101562817B1 (en)
CN (1) CN101861171B (en)
AU (1) AU2008278976B2 (en)
BR (1) BRPI0814470B1 (en)
CA (1) CA2694582C (en)
CY (1) CY1113022T1 (en)
DK (1) DK2175888T3 (en)
ES (1) ES2386849T3 (en)
FR (1) FR2919189A1 (en)
HK (1) HK1149211A1 (en)
HR (1) HRP20120526T1 (en)
IL (1) IL203512A (en)
MX (1) MX2010001013A (en)
PL (1) PL2175888T3 (en)
PT (1) PT2175888E (en)
RS (1) RS52405B (en)
RU (1) RU2481856C2 (en)
SI (1) SI2175888T1 (en)
WO (1) WO2009013358A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101664444B1 (en) * 2013-12-13 2016-10-12 재단법인 유타 인하 디디에스 및 신의료기술개발 공동연구소 Biodegradable medical adhesive or sealant compositions
RU2570114C1 (en) * 2014-09-17 2015-12-10 Федеральное государственное бюджетное учреждение науки Институт высокомолекулярных соединений Российской академии наук Method of obtaining water-soluble polymer complexes of radioisotopes
ES2846848T3 (en) 2015-10-26 2021-07-29 Harvard College Reduced and oxidized polysaccharides and methods of using them
PL240772B1 (en) * 2018-06-11 2022-06-06 Nanothea Spolka Akcyjna Method of producing polymer nanoparticles chelating radioactive isotopes for use in diagnostics and treatment
CN108785323B (en) * 2018-06-26 2020-09-18 中国医学科学院基础医学研究所 Spermine modified pullulan as immunopotentiator
CN115490774A (en) * 2022-08-16 2022-12-20 湖北第二师范学院 Spermine modified hydroxyethyl amylose gene transfection material and preparation method and application thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285857A1 (en) * 1974-09-27 1976-04-23 Pharmacia Fine Chemicals Ab MEDICAL CONTROL AGENT INTENDED TO BE ADMINISTERED BY INTRAVASCULAR ROUTE
WO2000021571A1 (en) * 1998-10-13 2000-04-20 Map Ab Ion exchange tumor targeting (iett)
FR2797769A1 (en) * 1999-09-01 2001-03-02 Cis Bio Int RADIOPHARMACEUTICAL PRODUCTS AND PROCESS FOR THEIR PREPARATION
WO2002041989A1 (en) * 2000-11-27 2002-05-30 Prometic Biosciences Ltd. Metal-chelating adsorbents and their use
JP2003104914A (en) * 2001-09-28 2003-04-09 Yasuhiko Tabata Complex of dna-metal-water-soluble polymer
WO2006088473A2 (en) * 2004-04-23 2006-08-24 Panduranga Rao Koritala Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6756363B1 (en) * 2000-11-17 2004-06-29 Wound Healing Of Oklahoma, Inc. Solutions and films of glycated chitosan
CN1308339C (en) 2005-02-28 2007-04-04 潘尚仁 99m Tc marked polyamine complex as tumor diagnosing developing agent and its preparation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2285857A1 (en) * 1974-09-27 1976-04-23 Pharmacia Fine Chemicals Ab MEDICAL CONTROL AGENT INTENDED TO BE ADMINISTERED BY INTRAVASCULAR ROUTE
WO2000021571A1 (en) * 1998-10-13 2000-04-20 Map Ab Ion exchange tumor targeting (iett)
FR2797769A1 (en) * 1999-09-01 2001-03-02 Cis Bio Int RADIOPHARMACEUTICAL PRODUCTS AND PROCESS FOR THEIR PREPARATION
WO2002041989A1 (en) * 2000-11-27 2002-05-30 Prometic Biosciences Ltd. Metal-chelating adsorbents and their use
JP2003104914A (en) * 2001-09-28 2003-04-09 Yasuhiko Tabata Complex of dna-metal-water-soluble polymer
WO2006088473A2 (en) * 2004-04-23 2006-08-24 Panduranga Rao Koritala Microcapsules and nanocapsules for the transmucosal delivery of therapeutic and diagnostic agents

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
AZZAM T ET AL: "Hydrophobized dextran-spermine conjugate as potential vector for in vitro gene transfection", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, vol. 96, no. 2, 28 April 2004 (2004-04-28), pages 309 - 323, XP004502179, ISSN: 0168-3659 *
ELIYAHU ET AL: "Relationships between chemical composition, physical properties and transfection efficiency of polysaccharide-spermine conjugates", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 27, no. 8, March 2006 (2006-03-01), pages 1646 - 1655, XP005193234, ISSN: 0142-9612 *
HOSSEINKHANI H ET AL: "Tumor targeting of gene expression through metal-coordinated conjugation with dextran", JOURNAL OF CONTROLLED RELEASE 07 MAR 2003 NETHERLANDS, vol. 88, no. 2, 7 March 2003 (2003-03-07), pages 297 - 312, XP004412771, ISSN: 0168-3659 *
LENUCCI ET AL: "Do polyamines contribute to plant cell wall assembly by forming amide bonds with pectins?", PHYTOCHEMISTRY, PERGAMON PRESS, GB, vol. 66, no. 21, November 2005 (2005-11-01), pages 2581 - 2594, XP005135736, ISSN: 0031-9422 *
SHALTIEL S ET AL: "HYDROPHOBIC CHROMATOGRAPHY USE FOR PURIFICATION OF GLYCOGEN SYNTHETASE EC-2.4.1.11", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 70, no. 3, 1973, pages 778 - 781, XP002464870, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
CA2694582C (en) 2016-02-16
BRPI0814470B1 (en) 2022-03-08
HRP20120526T1 (en) 2012-07-31
AU2008278976A1 (en) 2009-01-29
EP2175888B1 (en) 2012-06-13
WO2009013358A2 (en) 2009-01-29
JP5946241B2 (en) 2016-07-06
PT2175888E (en) 2012-07-23
KR20100089059A (en) 2010-08-11
PL2175888T3 (en) 2012-10-31
AU2008278976B2 (en) 2014-04-17
DK2175888T3 (en) 2012-07-09
EP2175888A2 (en) 2010-04-21
CA2694582A1 (en) 2009-01-29
RU2481856C2 (en) 2013-05-20
MX2010001013A (en) 2010-08-02
ES2386849T3 (en) 2012-09-03
US20100254906A1 (en) 2010-10-07
JP2010534732A (en) 2010-11-11
HK1149211A1 (en) 2011-09-30
IL203512A (en) 2015-01-29
CY1113022T1 (en) 2016-04-13
SI2175888T1 (en) 2012-10-30
BRPI0814470A2 (en) 2017-05-16
CN101861171B (en) 2013-07-17
US9023396B2 (en) 2015-05-05
RU2010107029A (en) 2011-09-10
KR101562817B1 (en) 2015-10-26
FR2919189A1 (en) 2009-01-30
CN101861171A (en) 2010-10-13
RS52405B (en) 2013-02-28

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