WO2009010303A2 - System for administering active substances to an organism, devices for use in said type of system and method for producing said type of devices - Google Patents

System for administering active substances to an organism, devices for use in said type of system and method for producing said type of devices Download PDF

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Publication number
WO2009010303A2
WO2009010303A2 PCT/EP2008/005919 EP2008005919W WO2009010303A2 WO 2009010303 A2 WO2009010303 A2 WO 2009010303A2 EP 2008005919 W EP2008005919 W EP 2008005919W WO 2009010303 A2 WO2009010303 A2 WO 2009010303A2
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WO
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Patent type
Prior art keywords
characterized
means
device
electrically conductive
according
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PCT/EP2008/005919
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German (de)
French (fr)
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WO2009010303A3 (en )
Inventor
Heribert Stephan
Werner Kraus
Stephanie Kraus
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Neue Magnetodyn Gmbh
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/002Magnetotherapy in combination with another treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N2/00Magnetotherapy
    • A61N2/02Magnetotherapy using magnetic fields produced by coils, including single turn loops or electromagnets

Abstract

The invention relates to a system for administering active substances to an organism, comprising at least one vibration generator (10), a coil arrangement (12, 14) that is electrically coupled to the vibration generator (10), at least one device (16, 42) that can be implanted in the region of a flowing body fluid and that consists at least partially of magnetically conductive material, and means (24, 26) for supplying paramagnetic nanoparticles with active substances that are coupled thereto in the flowing body fluids. The effect of the magnetic drug-targeting is improved, in which the highly magnetic gradient field is superimposed by a weak low-frequency electromagnetic field that synergistically improves the effect of the active substances or cells. Said synergistic effect can also be achieved by an alternating the use of the static highly magnetic field and the low-frequency electromagnetic field. The invention also relates to devices (16, 42) that can be implanted, to methods for the production thereof and systems and devices for carrying out telemetric measuring methods.

Description

System for administering active substances to an organism, means for use in such a system and process for the production of such devices

The invention relates to a system for administering

Active substances to an organism, means for use in such a system and process for the production of such devices.

In the administration of active substances to an organism, in particular intra-arterial or intravenous locoregional, in particular intravenous or application of active substances, such. As chemotherapeutic agents, antibiotics, or a suitable cell formulations based for example, on endothelial cells, there is a fundamental problem is that these low concentrations of the target region, or the site of action, for example, an organ or an implant, such as to reach a vascular prosthesis. So there are not only the target region with the active substances or cells in contact, but rather also healthy cells with either agent / cells at a concentration in contact, at which may affect the healthy cells and permanently damaged under certain circumstances.

To overcome this problem, the technique of "magnetic drug targeting" is used. The active compounds or cells to a paramagnetic or su- perparamagnetischen carrier are coupled. As a carrier can be used Na nopartikel, having the requisite properties magnetically tables. The area of ​​the patient to which the active ingredients are to be concentrated, is so arranged in a spatially varying magnetic field, a so-called gradient magnetic field that the active substances or cells concentrate in the area of ​​the target region. Thereby, the side effects are reduced for other regions of the body, as they come into contact with lower concentrations of the active substances or cells.

With the help of the magnetic targeting Although it is possible to concentrate the active substances or cells in the target region, which but sufficient efficacy can not always be aimed ER. Although this can be countered to some extent by the fact that the administration amount of active ingredients or cells is increased, so that ultimately there is a high probability that an effective interaction of the substances takes place with the affected cells, this being but again due to the high dosage the substances causes an additional load of the human body.

The invention is based on the object surfaces to enable it to apply biologically active substances or cells, to concentrate these active substances or cells after application and to enhance their effect locally synergistic.

This object is achieved with the features of the independent claims.

Advantageous embodiments of the invention are specified in the dependent claims.

The invention consists in a system for delivering active agents or cells to a target region in an organism, with at least one vibration generator, electrically coupled to the vibration generating coil arrangement, at least one implantable in the area of ​​a flowing body fluid means consisting at least partly of magnetically conductive material and means for supplying paramagnetic nanoparticles having coupled thereto agents into the flowing body fluid. The magnetic properties of the implantable device lead to a signal generated by the coil arrangement magnetic field is distorted in the region of the implantable device. Due to this distortion, a magnetic gradient field is even when the externally applied magnetic field is homogeneous, is generated. The water introduced into the flowing body fluid ferrofluid, ie the paramagnetic or superparamagnetic Na nopartikel with coupled thereto agents or cells can then be concentrated by the magnetic gradient field to the affected body regions. The implantable device may occur, especially in body fluids flowing through areas of the human body is used, ie especially in the bloodstream, in

Lymphatic system or in the urogenital tract. With particularly low frequency electromagnetic fields, the effectiveness of drugs amplified and / or differentiation of cells can be affected. As active ingredients in particular are chemotherapeutic agents to use.

, the term "chemotherapeutic agents" all chemically or naturally understand agents obtained which could have effect in an organism, in particular so any drugs. For example, the present invention can be used in the chemotherapeutic treatment of tumors by the chemotherapeutic agent is concentrated at the site of the tumor, thus other regions of the body by the chemotherapeutic agent or not less than conventionally be affected. When cells, for example endothelial cells can be administered to improve by their local attachment to a surface of the implant, the flowability of the implanted device by flowing blood, in particular by influencing the specific coagulation processes. Furthermore, angiogenesis is promoted, and the development of inflammation is suppressed. The administration of combinations chemotherapeuti- shear substances with cells can be considered.

Usefully, it is provided that the implantable device comprising a support with at least one introduced or applied magnetic conductive structure. As the carrier any biocompatible device can thus be used, which generally has no or only a negligible interaction with the externally applied magnetic field. By the introduced or applied magnetic conductive structures of the im- plantierbaren means are then mediates the properties that lead to advantageous distortion of the magnetic field and, finally, to the concentration of the supplied substances.

It can be provided that the magnetic conductive

Structure comprises a plurality of permanent magnetic particles with a regular orientation. Such a regular orientation of permanent magnetic particles can lead to a high concentration of the magnetic field in certain areas, so that ultimately, an advantageous concentration of the supplied substances in these areas can be expected. Alternatively or additionally, it may be provided that the magnetically permeable structure comprises a plurality shear ferromagnetic or paramagnetic particles.

According to a preferred embodiment of the invention, this is designed in such a way that the magnetically conductive structure as at least partially coherent net-like or spiral-shaped structure is formed. Such a net-like or spiral-shaped structure can be likewise incorporated into a carrier or applied to such and are fixed in this compound.

It is also conceivable that the implantable device at least two parts, wherein a first portion of a Trä- eng, and a second part is a magnetic-conductive mesh-like or spiral-shaped structure. As implantable device so a conventional implantable device can be used initially, the magnetic properties are then conveyed by the joining with a magnetically conductive net-like or spiral structure.

Usefully, it is provided that the net-like or spiral-shaped structure is formed of a metal-plastic compound. In this way, the advantageous properties can be used by plastics material, the magnetic properties can be provided by the metal content is available.

In this connection it may be advantageous that the net-like or spiral-shaped structure comprises a plastic-coated metal wire. Thus, the magnetic properties-providing metal wire does not come into contact with body tissue when this is coated with a biocompatible plastic.

It may be advantageous that the spiral structure is a spiral, wherein the distance between turns of the coil is substantially equal to a diameter of the metal wire. Here usefully wire diameter can be used in the range between 0.2 and 1 mm.

It is preferred that the carrier of the implantable device at least partially comprises a biocompatible plastic. Typical materials for implants so it can be usefully employed, for example, polytetrafluoroethylene (PTFE) or polyurethane.

According to another preferred embodiment of the invention it is provided that the implantable device carries an electrically conductive structure. can be arrangement to the vibration generator and the electrically coupled thereto a low-frequency electromagnetic field coil in the electrically conductive structure of the implantable device to induce, whereby electric fields and voltages in the vicinity thereof are generated. In particular, an additive protection against dangerous infections can thus be achieved. The transfer of the fields on the electrically conductive structure is carried out according to the transformer principle. The body region in which the implantable device is inserted, is extending from an extremely low frequency, in particular sinusoidal magnetic field with a frequency of approximately 1 to 100 Hz - preferably from 4 to 20 Hz - and a magnetic flux density of 0.5 to 5 mT flooded, which is generated by the vibration generator in the coupled with this coil. This extremely low frequency electromagnetic fields penetrate the tissue largely without losses, including any clothing and associations. In the electrically conductive structure thus electric potentials are indu- sheet which come into the region adjacent to the implantable device to tissue effect. Overall, this risk of infection is reduced in the region of the implantable device through their synergistic effect. The treatment parameters electric voltage, frequency, inten- sity, waveform and time of treatment can be determined by the specific programming of the vibration generator.

It may be of particular advantage that the electrically conductive structure at least partially an outer berflache O- of the implantable device is deposited. The arrangement of the structure on the outer surface is particularly in view of the ingrowth of vascular prosthesis is advantageous.

The application of the electrically conductive pattern can also take place in such a way that the electrically conductive structure is at least partially brought up to an outer surface of the implantable device by a sputtering technique.

Alternatively, or in addition to the arrangement of the electrically conductive structure on the surface, can be provided that the electrically conductive structure at least partially inside of the implantable device and external disposed inaccessible. It is particularly useful in that the electrically conductive structure has the character of at least an electric coil, which connects at least two electrodes to each other. In this manner, the electrically conductive structure receives a useful and designable as a function of the coil form response with respect to the introduced from the outside electromagnetic alternating fields.

Furthermore, the present invention in a particularly advantageous manner is formed by the fact that with the

Vibration generator coupled coil arrangement comprises at least one Helmholtz coil pair. A pair of Helmholtz coils is able to produce a substantially homogeneous magnetic field in the organism with the implanted input device is to be introduced. The required Gradienteneigenschaft of the magnetic field, which causes the addition nopartikel in the target region of the paramagnetic or superparamagnetic agents Na with the coupled thereto, is then generated by the magnetic properties of the implanted-mountable device. An almost homogeneous magnetic field can be generated for example by a solenoid coil.

It is also possible that the rator coupled to the Schwingungsgene- coil arrangement comprises at least a Maxwell coil pair. A Maxwell coil pair already generated externally an inhomogeneous magnetic field. By the magnetic properties of the implantable device, an additional distortion of the magnetic field is effected. In principle lent, the transport phenomena of the paramagnetic Na nopartikel also solely by the external inhomogeneous magnetic field of a Maxwell coil pair are effected so that, in principle, also implantable devices may be used without magnetic properties in connection with the presently described therapy.

It is also possible that the rator coupled to the Schwingungsgene- coil arrangement comprises at least one electromagnet with a one-dimensional wedge-shaped core. Even thus it is already possible to create the necessary external gradient.

It can be provided that in addition to the to the

Vibration generator coupled coils arrangement is provided a further means for generating a magnetic field. can in principle be generated electrically coupled to the vibration generating coil arrangement, both the weak low-frequency electromagnetic field as well as the strong magnetic gradient through the. but it may also be useful to decouple these functions and in particular to generate the gradient magnetic field by a separate device, for example a further Spulenan- order and / or by one or more permanent magnets.

The invention is realized in an advantageous manner in that an active substance reservoir (drug reservoir) is provided which serves in particular for recording of paramagnetic nanoparticles having coupled thereto drugs. The

Drug reservoir insofar as forming a further system component that may be located outside the body or implanted into the organism.

According to a particularly preferred embodiment of the invention it is provided that the implantable device is a Gefaßprothese. The wall of the Gefaßprothese carries out the described magnetically conductive and / or electri- cally conductive means, which are integrated in the wall and / or applied to one or both of the surfaces of the wall.

Also may be provided that the implantable device is a catheter. Since the active ingredients may be introduced via the catheter into the body, can achieve localization, which is then amplified by the gradient magnetic field already in the feeder.

According to a further preferred embodiment it is provided that the implantable device suture to tissue fixation or for fixing a biomaterial. For example, a heart valve can be fixed by suture material with magnetic properties, thereby z. For example, the deposition of bacteria and germs can be prevented.

Also may be provided that the suture an implanted in the area of ​​a flowing body fluid, at least partially fixed to existing means of magnetically conductive material. This suture a vascular prosthesis according to the invention can for example be implanted with magnetically conductive component.

It is usefully provided that the suture is a synthetic thread with embedded magnetically conductive material.

it may also be useful that the suture is a metallic thread with delta ferrite microstructure. There may further be provided that the magnetically conductive material is part of a secondary means for detecting measurement values ​​in or on an organism, wherein the impedance of the secondary device depends on a state of a tissue surrounding the implantable device, the electrically coupled to the vibration generating coil arrangement, external organism is placeable primary means for generating an alternating electromagnetic field in the region of the secondary device in an implanted state, and oriented that an organism external evaluation device for detecting and evaluating measured values ​​can be placed, depending on the impedance of the secondary device. Diseases of the coronary arteries are the main cause of death in the industrialized world. each year more than 1.5 million interventions to expansion of narrowed or blocked vessels are carried out worldwide. one of such interventions, for example, percutaneous transluminal coronary angioplasty (PTCA). In some of these interventions are vascular prostheses, called stents simultaneously implanted. The success of these measures is frequently questioned by the high probability of restenosis. At about 30 to 50% of patients in which a balloon dilatation is performed, and is carried out at about 22 to 30% of patients with stents within six months after the intervention restenosis, i.e., a re-narrowing of the vessels. In Germany alone, had to be at 25,000 patients a reoperation in 2000, thereby reducing costs of approximately 500 million euros were generated. A nose Reste- early detection, ie in particular in front of a damaged or complete blockage of a vessel, it is useful to diagnose the condition of the vessel in the diseased part after an operation. However, the diagnostic procedures currently in use is based on the recognition of Gefaßveranderungen on the detection of a reduced blood flow or gross changes in the arterial wall by imaging methods. These diagnostic procedures can inherently only show spate stages of change. The one with the imaging techniques often associated invasive administration of contrast agents may also lead to complications that can manifest itself in pain, perforation of the arteries, arrhythmias and, in the worst case, cardiac and cerebral infarctions. Another problem associated with the implantation of a Gefaßprothese represent infections. A high percentage of these infections leads to serious and life-threatening situations. The administration of high doses of antibiotics over a longer period often does not lead to the resolution of infection. ultimately it is only the exchange of Gefaßprothese with renewed surgical risk. The foregoing infection problem is not only related to vascular grafts, but also in other implants, such as osteosynthesis or endoprosthesis of joints or other skeletal components. Here infections are often caused by the formation of biofilms on the implants harboring example, difficult to combat multidrug-resistant Staphylococcus aureus (MRSA). On the basis of the presently discussed embodiment of the invention virtually any implants may be so equipped with electrical properties that they interact selfeld with a signal generated by an organism external electromagnetic alternating coil arrangement. This interaction is detectable externally organism in various ways, so that changes in the secondary device, in particular an implant can be detected on non-invasive basis. For example, as hyperplasia, that is, an excessive cell growth, are recognized in the interior of the stent, also the incipient formation of a biofilm on an implant.

In this context it is useful that the secondary means comprises an electrical oscillating circuit, depends on the impedance and resonant frequency of the state of the vicinity of the secondary device. Applies the alternating electromagnetic field externally generated the resonance frequency, this can be detected by the evaluation device and evaluated. will change the environment of the secondary device, either by cell growth, change in cross section in the vessel or biofilm formation, this has an influence on the impedance of the resonant circuit, thus increasing its resonant frequency changes. Consequently, the organism external evaluation device can detect a change in the area of ​​the implant, thus indicating a threatening complication.

It is particularly preferred that the resonant circuit forming electrically conductive means using thin film technology are applied to the implantable secondary device.

According to a preferred embodiment it is provided that the electrically conductive means comprises first electrically conductive applied to the implantable secondary device has means which form a component of a resonant circuit that is applied to the first electrically conductive means comprises an electrically insulating layer that on the electrically insulating layer second electrically conductive means are applied, which form a further part of the resonant circuit, and that the first electrically conductive means to said second electrically conductive means are in contact, so that the resonant circuit is formed. Thus, the necessary components of a resonant circuit can be precisely attached to the implant by use of thin film technology. Depending on the shape of the electrically conductive means inductance and capacitance of the resonant circuit can be varied.

It is particularly useful that the first electrically conductive means comprises an outer portion with windings and an interior portion having capacitive properties.

According to a further embodiment that the secondary means includes a measuring device which detects dependent upon the state of the vicinity of the secondary device readings, that the secondary means comprises a transmitting device which emits dependent on the measured values ​​of signals, and that an organism externally placeable receiving means is provided, provided is, receives the light emitted from the terminal device signals and delivers to the evaluating device. While the previously described embodiments of the telemetric Messkon- zeptes on the variation of the resonance frequency of a

The oscillating circuit is based, can also be provided to provide the secondary device with a measuring device which detects by sensors various properties in the area of ​​the device. This includes for example the pH-value in the range of the implanted device, the

provides information on changes, such as in the case of biofilm formation. Signals corresponding to the ER bordered by the measuring device values ​​can then be transmitted by a Sendeein- direction and evaluated externally organism. In this case, the application of the organism external alternating field thus serves primarily to the transport for the operation of the measuring device required energy in the body.

It may be useful that the transmitting device has at least one RFID transponder. In an RFID transponder is a device which only their cooperation game can "transmit" to an evaluation device and a receiving device realized by the information reader. Ultimately, the RFID transponder receives for this purpose, an electromagnetic high-frequency field which is generated by the evaluation device and the reader, to then modify this in function of data stored in the RFID transponder information. This change is detected by the evaluation device and the reader. Because of this limited compared to conventional active transmitters functionality of an RFID transponder, it is cost-effective and space-saving.

The invention may be further developed such that a readable information content of the RFID transponder in dependence on measurement values ​​which are supplied by the measuring means is changeable. In the simplest case, different voltages to the memory of the RFID transponder are created by the measuring device, these voltages reflect the captured by the measuring device contradictory properties. Different voltages can cause now that the memory contents of the RFID transponder is changed, so that, ultimately, the information transmitted from the RFID transponder to the evaluation device identifier is changed. DA is having the ability to change the memory contents of the RFID transponder, it is necessary to use writeable RFID transponders.

Alternatively or additionally possible that several RFID transponders are provided, which are activated or deactivated in dependence on measured values ​​supplied by the measuring device. In this case, recordable transponders are not sufficient. One or more threshold circuits, in which the measuring device and the RFID transponder are incorporated, ensure that different RFID transponders are active or inactive in response to the voltage supplied by the measuring device. In this way, the evaluation unit can therefore receive different identifiers depending on the supplied voltage from the measuring device, so also provide on this basis that the corresponding information is arranged on the organism external evaluation device are transmitted.

The invention further relates to devices which are implanted in the area of ​​a flowing body fluid, respectively, based on the telemetric measurement can represent any implant, said means having the properties described above and which is in particular a vascular prosthesis, a stent (stent) is a catheter, suture, osteosynthesis or an endoprosthesis.

The invention further consists in a method of producing a vascular prosthesis or catheter, comprising the steps of: preparing a biocompatible plastic, storing or disposing a magnetically conductive Materi- as in or on the plastic and providing the plastic with an electrically conductive structure. In this way, the advantages and characteristics of the system and the invention of the devices of the invention are implemented as part of a manufacturing process.

In this context, it is useful that the storing of the magnetic conductive material is in the plastic by dispersing.

The manufacturing method of the vascular prosthesis or catheter may be further formed to be used as magnetically conductive material permanently magnetic particles, wherein the plastic material with permanent magnetic particles is brought together in a casting process and the casting process is at least temporarily performed in the presence of an external magnetic field.

In this context, it is particularly useful that the external magnetic field is oriented radially.

It may further be provided that the annealing of the magnetically conductive material is accomplished by combining a support with a magnetically conductive net-like or spiral structure.

Furthermore, an advantage may be that the equipping of the plastic material with the electrically conductive structure is made by vapor deposition.

It is also possible that the equipping of the plastic is made with the electrically conductive structure by a sputtering technique. Furthermore, it can be advantageous that the equipping of the plastic material with the electrically conductive structure after molding, the shape of the stent graft takes place.

It is also possible that the equipping of the plastic material with the electrically conductive structure prior to molding of the shape of the stent graft takes place.

An inventive method may be configured such that it comprises the steps of: depositing the first electrically conductive means to the biocompatible plastic material which are to form part of a resonant circuit, applying an electrically insulating layer on the electrically conductive agent, applying said second electrically conducting means to the electrically insulating layer which are to form a further part of the resonant circuit, and contacting the first electrically conductive means to said second electrically conductive means so that the resonant circuit is formed. In this way, a structure is provided by a few steps, which is required for the resonance frequency analysis functionality.

It is usefully provided that the first electrically conductive means comprises an outer portion with windings and an interior portion having capacitive properties.

It is further advantageous that the application of the ERS th effected electrically conducting means and / or the electrically insulating layer and / or the second electrically conductive means using thin film technology. The invention further relates to a method for producing a magnetically conductive suture material, comprising the steps of: forming a plastic melt, incorporating a magnetically conductive material in the plastic melt and producing a thread by applying a melt spinning method.

It can be provided that a plastic from the group of polyvinylidene fluoride (PVDF), polyamide, especially PA6,

Polyester, polytetrafluoroethylene (PTFE) and terephthalate is used.

According to a particularly preferred embodiment of the method it is provided that a magnetically conductive material from the group of Fe 3 O 4, Sr-ferrite, NdFeB, SmCo and AlNi- Co is used. It can be used both soft magnetic and hard magnetic materials. magnetically isotropic and anisotropic materials may also be used. As the soft magnetic material is, for example, Fe 3 O 4 is used, which assumes superparamagnetic magnetic properties of a certain particle size between 1 and 100 nm. When hard magnetic materials Sr ferrite, NdFeB, SmCo and AlNiCo come set to turn on, the typical Koerzitivfeidstärken of hard magnetic materials are above 10 4 A / m. In the soft magnetic materials, the coercive field strength in the range of 10 1 is "3 to 10 A / m. The particle sizes are preferably, for example, SR-ferrite, wherein 1 to 10 microns and NdFeB between 100 and 400 microns.

It can be provided that when using a magnetically anisotropic magnetic conductive material, the melting is spinning process at least temporarily performed in the presence of an external magnetic field. This results in an orientation of magnetization within the suture.

Using the example of a vascular prosthesis some features of the invention are summarized and explained in more detail below. The vascular prosthesis has in the simplest case, the shape of a tube. This has for example a length be- see 1.5 and 10 cm, a diameter from 1.0 to 6 mm and a wall thickness between 0.2 and 1.0 mm. The hose consists of an elastic biocompatible plastic, for example Teflon or polyurethane, was introduced into the in its manufacture a magnetically conductive substance, such as a ferrite about by dispersing. embedded on the outside and / or inside and / or in the material of the FerritkunststoffSchlauches pattern of electrically highly conductive material are provided on the outer side preferably by vapor deposition or sputtering. This may take the form of coils, induced by a weak external low-frequency electromagnetic field, generate electric fields and voltages distributed particularly on the surface of the FerritkunststoffSchlauches. This allows the Einwachsver- will hold into the surrounding tissue improves, and it is a protection against dangerous infections developed. This therapeutic effect is demonstrated by applications of Magnetodyn- process according to Kraus and Lechner for more than three decades and published, in particular severe disturbances of bone and wound healing, often resistierender in subsequent infections, were overcome by the process in the past. To improve the local efficiency of the therapy and reduction of systemic side effects active substances or cells in the vicinity of the vascular prosthesis are accumulated by means of magnetic targeting paramagnetic or superparamagnetic nanoparticle as a drug carrier in a strong external Mag- netfeld locally. The effect of the magnetic targeting drug designation is improved by the strong magnetic gradient field is superimposed by a weak low-frequency electromagnetic field, which synergistically enhances the effect of the active substances or cells. This synergistic see effect can be achieved by an alternating use of static strong magnetic field and the low-frequency electromagnetic field. In order to avoid residual magnetism due to the remanence of the substances involved after switching off the alternating magnetic field, it is preferable to program the function generator so that a cut-off at the zero crossing of the magnetic vibration takes place. With regard to the programming of the function generator can still be advantageous that short, steep-edged pulses to the mechanical excitation of the nanoparticles are administered. In this way, the detachment of adherent cells bound drugs or is promoted, so that they can then act in released form the body's cells.

The invention will now be described by way of example with reference to the accompanying drawing with reference to a particularly preferred embodiment.

Show it:

Figure 1 is a schematic representation of a system according to the invention with a vascular prosthesis according to the invention; 2 shows a perspective view of a first

Embodiment of an inventive vascular prosthesis;

3 shows a perspective view of a second

Embodiment of an inventive vascular prosthesis;

4 shows a perspective view of a third embodiment of a vascular prosthesis according to the invention;

5 shows a perspective view of a fourth embodiment of a vascular prosthesis according to the invention;

6 shows a perspective view of a fifth

Embodiment of an inventive vascular prosthesis;

Figure 7 is a sectional view of an exemplary coil assembly disposed in the magnetic field of vascular prosthesis;

Figure 8 is a sectional view of a further exemplary coil assembly disposed in the magnetic field of vascular prosthesis;

9 shows various systems to generate different magnetic field gradients; Figure 10 is a perspective view of an electromagnet for use in the present invention, and

Figure 11 is a schematic representation of erfindungsgema- SSEM suture;

12 shows a further embodiment of a erfindungsge- reasonably system;

13 shows a further embodiment of a system and reasonably erfindungsge-

14 shows a secondary device for use in an inventive system.

1 shows a schematic representation of an inventive system with an inventive Gefaßprothese. Outside of a body to be treated is a vibration generator 10, and a thus electrically related coil assembly 12, 14, the present case consists of two parallel coils, is provided. A tubular Gefaßprothese 16, in the wall of magnetically conductive material is incorporated is implanted in the body to be treated and with the body to be treated in the magnetic field of the coil assembly 12, 14 is arranged. The Gefaßprothese 16 communicates with a drug designation reservoir 24 via a catheter 26 through the bloodstream in combination, wherein the drug designation reservoir 24 may be disposed outside or inside the human body directly or indirectly. On the outer surface of the Gefaßprothese 16 is an electrically conductive structure 18, 20 is arranged, 22, the play in the present Ausfuhrungsbei- a coil winding 18, and has through this coil winding 18 interconnected surface electrodes 20, 22nd

The electrically communicating with the vibration generator 10 coil arrangement 12, 14 may be provided for generating a homogeneous magnetic fields or for generating gradient fields. Be homogeneous magnetic fields are used, the ER ford variable for the magnetic targeting magnetic gradient field is generated in a different manner, in particular by the distortion of the magnetic field due to the incorporated in the vascular prosthesis magnetically conductive material. If the magnetic field already generated externally through the coil assembly 12, 14 so can be used in principle without any local distortion of the magnetic fields, which can also be used in addition.

26 active substances or cells are introduced into the vascular prosthesis 16 of drug reservoir 24 via the catheter, wherein the active compounds are coupled to paramagnetic nanoparticles. By a static magnetic gradient field is generated by the function generator 10, the paramagnetic nanoparticles with the active substance may be located at one or more sites of the body. Further, the vibration generator 10 generates a low-frequency alternating electromagnetic field, which favors the transport of substances through the cell membrane. A further effect of the low-frequency alternating field consists in the fact that the healing process of the vascular prosthesis and is favored in particular not affected by infection. In the present embodiment, both the static magnetic gradient field as well as the low-frequency alternating electromagnetic field by the same generator 10 and the same coil arrangement 12, 14 are generated. Basically it is also possible to separate these functions in whole or in part, that is, to control various coils with the same function generator, which then but each assume the task of generating the static field, or the generation of the alternating field, or even different function generators and various coils with the various tasks vorzuse- hen. Furthermore, it is also possible to realize the generation of the static magnetic field with a permanent magnetic field or support.

Figures 2 to 6 show perspective views of various embodiments of vascular prostheses. The details shown and described can equally apply to other implantable devices, such as catheters. The vascular prosthesis according to Figure 2 comprises a support 28, which preferably consists of egg nem biocompatible plastic. With the support 28 is a magnetically conductive structure 30 in connection which is formed here by a plurality of ferromagnetic or paramagnetic particles 32nd Also, the magnetically permeable structure may be constituted by permanent-magnetic particles, as will be explained below with reference to Figure 5 in more detail. These particles are incorporated, for example, in the biocompatible plastic material of the carrier 28, or they can also be applied to the outer wall or the inner wall of the vascular prosthesis sixteenth

In the embodiment according to Figure 3, the carrier 28 of the vascular prosthesis 16 on a net-like structure of magnetically conductive 36th This too can be incorporated or in the carrier out of biocompatibility patiblem plastic applied on the outside or the inside. The net-like structure 36 may be paramagnetic, ferromagnetic or permanently magnetic.

In the embodiment of Figure 4, the vascular prosthesis 16 is disposed a spiral structure 38 in the group consisting of biocompatible plastic carrier, which may be ferromagnetic, paramagnetic or permanently magnetic. The magnetically conductive structure 38 can be incorporated into the carrier 38, or it is applied to the outer or inner side of the carrier 28th

The vascular prosthesis 16 according to Figure 5 has a support 28 with embedded permanent magnetic particles 34. This is illustrated in the sectional view A, being also shown here that the permanent magnetic particles can be oriented in the radial direction 34th This can be achieved by a strong magnetic field is applied in the radial direction during the dispersion of biocompatible synthetic material with the permanent magnetic particles. Also with regard to the ferromagnetic particles, it is possible to store them on the outside or the inside of the vascular prosthesis sixteenth

The vascular prosthesis 16 of Figure 6 is in two parts. The carrier 28 may be realized as conventional vascular prosthesis, while the magnetically permeable structure in the form of a spiral can be subsequently pushed onto the finished se vascular prosthesis 28 38th The spiral 38 can be paramagnetic, ferromagnetic or permanently magnetic. It can be made of a wire or of a metal-plastic compound. Figure 7 shows a sectional view of an exemplary coil assembly disposed in the magnetic field of Gefäßpro ¬ synthesis. There is shown a Helmholtz coil assembly 12, 14, which produces a substantially homogeneous magnetic field in the region between the coils 12, 14th Arranged between the coils 12, 14 implantable device 16 carries an electrically conductive structure 18, which connects two electrodes 20, 22 with each other.

Figure 8 shows a sectional view of a further exemplary coil assembly disposed in the magnetic field of vascular prosthesis. The coil assembly 12 is a single solenoid coil here, wherein How-inside of the solenoid coil 12 derum a substantially homogeneous magnetic field is generated. The implantable device 16 is disposed inside the solenoid coil 12, wherein a substantially helically shaped electrically conductive structure connects two electrodes 18 20, 22 together.

Figure 9 shows various systems to generate different magnetic field gradients. In the upper part of Figure 9, a pair of Helmholtz coils 12, 14 having disposed therein implantable device and an associated magnetic field pattern B along the axial extension X of the implantable device are shown sixteenth a corresponding array of permanent magnets 44, 46 is also shown, which produces a similar magnetic field profile. In the lower portion of the figure 9 is a Maxwellspu- is lena proper 12 ', 14' is shown, whereby it from the

Helmholtz coil assembly 12, 14 in the upper portion of the figure 9 differs in that the coils 12 ', 14' in the opposite direction and not in the same direction as the coils 12, 14 of the Helmholtz coil pair are wound. The associated magnetic field pattern B along the axial extension X along the implantable device 16 is also shown. Also generated with two permanent magnets 48, 50 of similar magnetic field profile is shown. It can be seen that the Helmholtz coil pair 12, 14 produces a substantially homogeneous magnetic field. In order to provide the necessary gradient fields in the area of ​​the implantable device 16 is available, the implantable device is equipped with a magnetically conductive structure. The Maxwell coil pair 12 ', 14' produces a strong inhomogeneous magnetic field. The magnetic field gradient is thus already generated externally, so that the implantable device 16 may be used without magnetically conductive structure.

Figure 10 shows a perspective view of a E- lektromagneten for use in the present invention. The electromagnet shown here with one dimensional wedge-shaped core 40 and a coil winding 12 can serve the one-dimensional field distortion. In particular, several differently arranged electromagnets can be designated is provided to produce on a cylinder, in particular a vascular prosthesis or catheter, a plurality of extending in the axial direction enrichment lines.

Figure 11 shows a schematic illustration of inventive sutures. The suture 42 includes mag- netic conductive particles 42, for example ferromagnetic or paramagnetic particles cal. The suture 42 may for example be used to implants in the range of flowing body fluids .beispielsweise heart valves made of organic material, sew. Also, the suture 42 may be used to secure artificial implantable devices, in particular the beschriebe- nen in connection with the present invention, implantable devices such as vascular prostheses.

Figure 12 shows a further embodiment of a system according to the invention. In an organism, 110, that is, in particular, a living human body, a secondary device 112 is implanted. External organism is a coil assembly 114, 116 is provided, which acts as a primary means and adapted to bear witness ER- an electromagnetic field in the region of the secondary device 112th The coil assembly may, for example, as shown, be realized by Helmholtz coils 114, 116, but also in other ways. It is essential that in the area of ​​the secondary device 112, an electromagnetic field is present. The organism external coils 114, 116 are powered by a power function generator 118 with energy.

The secondary device 112 is now equipped with electrically conductive means 122, which form an electrical oscillating circuit. The impedance and resonant frequency the electric oscillating circuit depends on the state of its environment, ie in particular by the tissue condition, the presence or absence of biofilms or by any other parameters that reflect the conditions in the organism 110th If now the frequency of functional current generator 118, for example, set so that it corresponds to the resonant frequency of the resonant circuit formed by the electrically conducting means 122 so that the resonance state can be monitored by the evaluation 120th now shifts the resonance frequency of organism internal oscillation circuit, are thus changes in the area of ​​the secondary device 112 before, so this is also detected by the evaluation 120th This can, for example, in the case that there is a stent in the secondary device 112, pointing to excessive cell growth. Also, as the formation of biofilms on implants that form the secondary device 112 can be detected early. It is not absolutely necessary to operate the external alternating field with the resonant frequency of the resonant circuit; Other spectral components are influenced by the changing conditions in the region of the secondary device.

Figure 13 shows a second embodiment of a system according to the invention. In contrast to the embodiment of FIG 12, the state detection of the secondary device 112 is not necessarily based here on the monitoring of a resonant condition. Rather, the secondary device 112 having a measuring device 134 and a transmitting device 136 is equipped. The measuring device 134 and the transmitting device 136 are supplied via the electrically conductive means 122 with energy that relate to the electrically conducting means 122 from the organism external from the coil assembly 114, 116 generated electromagnetic field. The measuring device 134 may include any sensors to detect the state parameters in the field of secondary device 112th For example, impedances can again be detected or even other parameters, for example the pH, in the latter case usefully comprises the measuring device 134 an ion-sensitive field effect transistor. The emitted by the transmitting device 136 signals are received by a receiving device 138 which passes them to an evaluation device 120th

The devices described in connection with the previously described embodiments according to figures 12 and 13, in particular the electrical means 122, the measuring device 134, the transmission device 136, the receiving device 138, the evaluation device 120 and the functional power generator 118 may individually and in an integrated form can be realized. For example, it is possible in the embodiment according to Figure 13 in that the electrical means 122, the measuring device 134 and the transmitting means REA 136 partially or fully integrated are lisiert. the receiving device 138 and / or the evaluation device 120 may be integrated with the function of current generator 118 also completely or partially.

Figure 14 shows a secondary device for use in an inventive system. The secondary device 112 supports electrically conductive means 122 that form an electrical oscillating circuit 124th An outer portion 130 of the electrically conductive means 122 has windings, that is inductive properties, while an inner region 132 has capacitive properties. In order to realize the resonant circuit, the realized by solid lines conductor structure, for example, is first applied to the electrically insulating secondary device 112th This conductor pattern is referred to as first electrically conductive means 126th If the secondary device 112 is not isolated in any case, an insulating layer on the secondary device 112 is applied prior to the application of the first electrically conductive means 126th After application of the first electrically conductive means 126, an insulation layer is applied to the first electrically conductive means 126th Subsequently, second electrically conductive means are applied to the not visible here insulating layer 128th The electrically conducting means 126, 128 to contact so that an electrical resonant circuit is formed 124 two contacts between the first electrically conductive means 126 and the second electrically conductive means 28 made, namely once at one pole of the parallel connected Kondenstoren in the interior 132 the arrangement and on the other at the outer pole of the inductive outer region 130. in order to realize the layer structure described, various thin-film technologies can be used, which can be used in combination, namely, for example, physical (PVD) and chemical vapor deposition (CVD). Also sputtering techniques can be used.

In connection with the embodiments of Figures 12 to 14 thus in particular two different concepts for measuring a property to the implanted secondary device to be used. At the first measurement principle in a simple way, a change in impedance or the resonant frequency of the implanted resonant circuit is evaluated. This method does not require any active components in the organism, so that the issue of biocompatibility is reduced. The external field operates preferably in a range between a kHz up to a GHz, preferably in the range between 4 kHz and 120 kHz. The second measuring principle is based on the coupling of electromagnetic energy in the secondary device, then the actual detection of the environmental condition is supported by active components. Here it comes therefore less important to use the aforementioned optimum frequency range to detect impedance changes; rather, the frequency can be selected, for example, so that as much energy is transferred as quickly as possible, or else the frequency range used is determined based on entirely different criteria. One can think mainly because that found according to the technique according to Kraus and Lechner alternating electromagnetic fields to their use in connection with Stützme- tall-Osteosyntheseeinrichtungen or joint replacement. To this end, coil assemblies, called Transducer or transformer coils, integrated into these implants, and their poles are electrically comparable with acting as an electrode implant sections connected. An example of a Osteosyntheseeinrichtug, which makes use of the described technique is Al disclosed in DE 10 2006 018 191st The Hüftkopfkappenimplantate described in 10 2004 024 473 Al are examples of the use of technology in the Gelekendoprothetik. Thus it tunes the organism external coils on for the required in the technique according to Kraus and Lechner frequency range of 1 to 30 Hz, preferably 10 to 20 Hz decreases, so this technique can on the one hand be applied flat and on the other hand he for operating the measuring device - ford variable energy is transferred into the inventive system. Another example in which the present invention may be usefully employed due to the dual function of the organism external magnetic field, is the realm of drug-targeting. In this case, implants are provided with magnetically conductive properties so that is made by external magnetic fields, a concentration of the magnetic field in the area of ​​the implantable device. the implantable device in the area is flowing body fluids, for example in a blood vessel, a concentration can be obtained by administration of paramagnetic Na nopartikel coupled thereto with active substances or cells in the same place in the area of ​​the implantable device. Both the first embodiment of the present invention with the naked electric oscillating circuit and the second embodiment with the active components can be combined with the drug-targeting technology by the electromagnetic field organism externally generated on the one hand in the region of the implant for the purpose of concentration of active substances or cells is concentrated on the other hand either resonance frequency technically monitored or provides energy for the active components in the area of ​​the implant are available.

The features disclosed in the foregoing description, in the drawing and in the claims the invention may, both separately and in any combination essential to the realization of the invention.

LIST OF REFERENCE NUMBERS

10 vibration generator

12 coil

14 coil

16 implantable device

18 electrically conductive electrode structure 20

22 electrode

24 Drug Reservoir

26 fluid supply

28 support 30 magnetically conductive structure

32 ferromagnetic / paramangetische particles

34 permanent magnetic particles

36 net-like structure

38 helical structure 40 core

42 thread

44 permanent magnet

46 permanent magnet

48 permanent magnet 50 permanent magnet

110 organism

112 secondary device

114 coil arrangement

116 coil assembly 118 Function Generator

120 evaluation

122 electrically conductive means

124 electric oscillating circuit 126 electrically conductive means

128 electrically conductive means

130 Outside

132 Interior

134 measuring device

136 transmitter

138 receiver

Claims

1. System for delivering active agents or cells to a target region in an organism, with
at least one vibration generator (10),
- electrically coupled to a vibration generator (10) coil assembly (12, 14),
at least one implantable in the area of ​​a flowing body fluid means (16, 42) consisting at least partially of magnetically conductive material, and
Means (24, 26) for feeding particulate paramagnetic nano coupled thereto with agents into the flowing body fluid.
2. System according to claim 1, characterized in that the implantable device (16, 42) comprises a carrier (28) with at least one introduced or applied mag- netic conductive structure (30).
3. System according to claim 2, characterized in that the magnetically conductive structure (30) comprises a plurality of permanent magnetic particles (34) with a regular orien- tation.
4. System according to claim 2 or 3, characterized in that the magnetically conductive structure (30) comprises a plurality of ferromagnetic or paramagnetic particles comprises (32).
5. System according to any one of claims 2 to 4, characterized indicates overall that the magnetically conductive structure as at least partially coherent net-like or spiral-shaped structure (36, 38) is formed.
6. System according to one of the preceding claims, DA by that the implantable device
(16) is at least two parts, wherein a first part is a support (28) and a second part of a magnetically conductive net-like or spiral-shaped structure (38).
7. System according to claim 6, characterized in that the net-like or spiral-shaped structure (36, 38) is formed of a metal-plastic compound.
8. System according to claim 7, characterized in that the net-like or spiral-shaped structure (36, 38) comprises a plastic-coated metal wire.
9. System according to claim 8, characterized in that the spiral structure is a spiral (38), wherein the distance between turns of the coil is substantially equal to a diameter of the metal wire.
10. System according to any one of the preceding claims, characterized in that the support (28) of the cash implantable device (16, 42) at least partially made of a biocompatible plastic.
11. System according to any one of the preceding claims, characterized in that the implantable device (16) carries an electrically conductive structure (18).
12. System according to claim 11, characterized in that the electrically conductive structure (18) is at least partially deposited on an outer surface of the implantable device (16).
13. The system of claim 11 or 12, characterized in that the electrically conductive structure 18, 20, 22) is at least partially applied to an outer surface of the implantable device (16) by a sputtering technique.
14. System according to any one of claims 11 to 13, characterized in that the electrically conductive structure (18, 20, 22) is arranged at least partly inaccessible in the interior of the implantable device and from the outside.
15. System according to one of claims 11 to 14, characterized in that the electrically conductive structure has the character of at least one electrical coil (18), the at least two electrodes (20, 22) together.
16. System according to any one of the preceding claims, characterized in that the vibration generator
(10) coupled to the coil arrangement comprises at least one Helmholtz coil pair (12, 14).
17. System according to any one of the preceding claims, characterized in that the vibration generator coupled to the coil arrangement comprises at least a Maxwell coil pair (12 1, 14 ').
18. System according to any one of the preceding claims, data carried in that the vibration generator coupled to the coil arrangement (12, 40) comprises at least one electromagnet with a one-dimensional wedge-shaped core (40).
19. System according to any one of the preceding claims, characterized in that additionally coupled to the to the vibration generator (10) coil assembly (12, 14) is provided a further means for generating a magnetic field.
20. System according to any one of the preceding claims, characterized in that an active substance reservoir (drug designation reservoir) is provided (24) which serves in particular the recording of paramagnetic nanoparticles having coupled thereto drugs.
21. System according to any one of the preceding claims, characterized in that the implantable device is a vascular prosthesis (16)
22. System according to any one of the preceding claims, characterized in that the implantable device is a catheter.
23. System according to any one of the preceding claims, characterized in that the implantable device suture (42) for tissue fixation or for fixing a biomaterial.
24. System according to claim 23, characterized in that the suture material an implanted in the area of ​​a flowing body fluid, fixed to at least partly made of magnetically conductive material (16).
25. The system of claim 23 or 24, characterized in that the suture (42) is a plastic thread with embedded magnetically conductive material (34).
26. The system of claim 23 or 24, characterized in that the suture (42) is a metal thread with delta ferrite microstructure.
27. System according to any one of the preceding claims, characterized in that
that said magnetically conducting material is part of a secondary device (112) for acquiring measured values ​​in or on an organism, wherein the impedance of the secondary device depends on a state of a tissue surrounding the implantable device,
- that the vibration generator (118) electrically coupled coils arrangement (114, 116) is an organism Ext placeable primary means for generating an alternating electromagnetic field in the region of the secondary device in an implanted state, and
that an organism external evaluation device (120) is placeable for detecting and evaluating measured values ​​which depend on the impedance of the secondary device.
28. System according to claim 27, characterized in that the secondary means includes an electrical resonant circuit
(124) depends whose impedance and resonant frequency of the state of the vicinity of the secondary device.
29. The system of claim 28, characterized in that the resonant circuit (124) forming electrically conductive means
(122) using thin film technology on the implantable secondary means (112) are applied.
30. System, characterized denotes overall according to any one of claims 27 to 29,
that the electrically conductive means comprises first electrically conductive means to the implanted secondary applied means (126) comprise forming a loading component of a resonant circuit,
that an electrically insulating layer is applied to the first electrically conductive means,
- that on the electrically insulating layer second electrically conductive means (128) are mounted, which form a further part of the resonant circuit, and
- that the first electrically conducting means are in contact with the second electrically conductive means, so that the resonant circuit is formed.
31. The system of claim 30, characterized in that the first electrically conductive means comprises an outer region
(130) with windings and an inner portion (132) with kapa ¬ zitiven properties.
Characterized in 32. System according to any one of claims 27 to 31,
that the secondary means (112) processing a Messeinrich- (134) which detects dependent upon the state of the vicinity of the secondary device measured values,
that the secondary means includes a transmitting means (136) which emits dependent on the measured values ​​of signals, and
that an organism placeable externally receiving means (138) is provided from the terminal (136) receives transmitted signals and provides to the evaluation device.
33. System according to claim 32, characterized in that the transmission means (136) comprises at least one RFID transponder.
34. The system of claim 33, characterized in that a readable information content of the RFID transponder in response to measured values ​​of the measuring device
(134) are supplied, can be varied.
35. The system of any one of claims 32 to 34, characterized in that several RFID transponders are provided, which are supplied as a function of measured values ​​of the measuring device (134) can be activated or can be deactivated.
36. means (16, 42)) that is implantable in the area of ​​a flowing body fluid and a magnetically permeable structure (30).
having 37. A device according to claim 36, characterized in that it comprises a support (28) with at least one eingebrach- th or applied magnetically conductive structure (30).
comprises 38. A device according to claim 37, characterized in that the magnetically conductive structure (30) includes a plurality of permanent magnetic particles (34).
39. Apparatus according to claim 37 or 38, characterized in that the magnetically conductive structure (30) comprises a plurality of ferromagnetic or paramagnetic particles (32).
40. Device according to one of claims 37 to 39, characterized in that the magnetically conductive structure
is formed (30) at least partially coherent net-like or spiral-shaped structure (36, 38).
41. Device according to one of claims 36 to 40, characterized in that the implantable device
(16) is at least two parts, wherein a first part is a support (28) and a second part of a magnetically conductive net-like or spiral-shaped structure (38).
42. A device according to claim 41, characterized in that the net-like or spiral-shaped structure (36, 38) is formed of a metal-plastic compound.
43. A device according to claim 42, characterized in that the net-like or spiral-shaped structure (36, 38) comprises a plastic-coated metal wire.
44. A device according to claim 43, characterized in that the spiral structure is a spiral, wherein the distance between turns of the coil (38) is substantially equal to a diameter of the metal wire.
45. Device according to one of claims 36 to 44, data characterized by that the carrier of the implantable
Means (16) at least partially comprises a biocompatible plastic.
46. ​​Device according to one of claims 36 to 45, by DA in that it an electrically conductive
Structure (18, 20, 22).
47. A device according to claim 46, characterized in that the electrically conductive structure (18, 20, 22) zumin- least partially on an outer surface of the implantable device (16) is vapor-deposited.
48. A device according to claim 46 or 47, characterized in that the electrically conductive structure (18, 20, 22) is at least partially applied to an outer surface of the implantable device (16) by a sputtering technique.
49. Device according to one of claims 46 to 48, characterized in that the electrically conductive structure (18, 20, 22) is at least partially arranged in the interior of the implantable device (16) and inaccessible from outside reasonable.
having 50. Device according to one of claims 46 to 49, characterized in that the electrically conductive structure of the character at least one electrical coil (18), which connects at least two electrodes (20, 22) together.
51. Device according to one of claims 36 to 50, characterized in that the means (16) is a vascular prosthesis.
52. Device according to one of claims 36 to 50, characterized in that the device is a catheter.
53. Device according to one of claims 36 to 50, characterized in that the implantable device suture (42) for fixing a further implantable device.
54. A device according to claim 53, characterized in that the suture (42) is a plastic thread with embedded magnetically conductive material (34).
55. A device according to claim 53 or 54, characterized in that the suture (42) is a metal thread with delta ferrite microstructure.
having 56. A device according to claim 55, characterized in that it comprises a resonant electrical circuit (124) depends whose impedance and resonant frequency of the state of the vicinity of the secondary device.
57. A device according to claim 57, characterized in that the resonant circuit (124) forming electrically conductive means (122) using thin film technology to the secondary implantable device (112) listed are introduced.
58. A device according to claim 57, characterized in that
that the electrically conductive means (122) on the first electrically conductive means is applied means (126) comprise forming a part of a resonant circuit (122),
that an electrically insulating layer is applied to the first electrically conductive means,
that on the electrically insulating layer second electrically conductive means (128) are mounted, which form a further part of the resonant circuit, and
that the first electrically conducting means are in contact with the second electrically conductive means, so that the resonant circuit is formed.
59. Apparatus according to claim 58, characterized in that the first electrically conductive means (122) with windings and an inner portion (132) having capacitive characteristics have a ßenbereich Au (130).
60. A device according to claim 54, characterized in that
that the secondary implantable device (112) has a measuring means (134) for detecting the state of the environment of the implantable secondary means (112) dependent measurement values,
that the device has a transmitting means (136) which emits dependent on the measured values ​​of signals, and
- that an organism placeable externally receiving means (138) is provided which receives the light emitted from the terminal device signals and delivers to the evaluating device.
61. A device according to claim 60, characterized in that the transmitting device (138) has at least one RFID transponder.
62. Apparatus according to claim 61, characterized in that a readable information content of the RFID
Is variable transponder as a function of measured values ​​supplied by the measuring device (134).
63. The system of any one of claims 60 to 62, characterized in that several RFID transponders are provided, which are supplied as a function of measured values ​​of the measuring device (134) can be activated or can be deactivated.
64. A method for producing a vascular prosthesis (16) or a catheter, comprising the steps of:
- Preparing a biocompatible plastic,
Storing or disposing a magnetically conductive material (32, 34, 36, 38) in or on the plastic and
- providing the plastic with an electrically conductive structure.
65. The method of claim 64, characterized in that the storing of the magnetically conductive material (32, 34, 36, 38) takes place in the plastic material by dispersing.
66. The method of claim 64 or 65, characterized in that the magnetically conductive material permanently magnetic particles (34) are used, wherein the plastic material with permanent magnetic particles is brought together in a casting process and the casting process is at least temporarily performed in the presence of an external magnetic field.
67. A method according to claim 66, characterized in that the external magnetic field is oriented radially.
68. A method according to any one of claims 64 to 67, characterized in that the annealing of the magnetically conductive material is accomplished by combining a carrier (28) with a magnetically conductive net-like or spiral-shaped structure (38).
69. A method according to any one of claims 64 to 68, characterized in that the equipping of the plastic material with the electrically conductive structure (18, 20, 22) takes place by vapor deposition.
70. A method according to any one of claims 64 to 68, characterized in that the equipping of the plastic material with the electrically conductive structure (18, 20, 22) is performed by a sputtering technique.
71. A method according to any one of claims 64 to 70, characterized in that the equipping of the plastic material with the electrically conductive structure (18, 20, 22) is carried out after forming the shape of the vascular prosthesis (16).
72. A method according to any one of claims 64 to 71, characterized in that the equipping of the plastic material with the electrically conductive structure (18, 20, 22) is carried out prior to forming the shape of the vascular prosthesis (16).
73. A method according to any one of claims 64 to 72, characterized in that it comprises the steps of:
Applying first electrically conductive means (126) to the biocompatible plastic material which are to form part of a resonant circuit (124),
Applying an electrically insulating layer on the electrically conductive means,
Applying the second electrically conductive means (128) on the electrically insulating layer which are to form a further part of the resonant circuit (124), and
Contacting the first electrically conductive means to said second electrically conductive means, so that the resonant circuit is formed.
(130) with windings and an inner portion (132) having capacitive characteristics comprise 74. The method according to claim 73, characterized in that the first electrically conductive means comprises an outer area.
75. The method according to claim 73 or 74, characterized in that deposition of the first electrically conductive means (126) and / or the electrically insulating layer and / or the second electrically conductive means (128) using thin-film technology is performed.
76. A method for producing a magnetically conductive suture (42), comprising the steps of:
Producing a plastic melt,
- introduction of magnetically conductive material (34) to the plastic melt and
Generating a thread (42) by applying a melt spinning method.
77. A method according to claim 76, characterized in that a plastic from the group of polyvinylidene fluoride (PVDF), polyamide, especially PA6, polyester, polytetramethylene fluoroethylene (PTFE) and terephthalate is used.
78. The method of claim 76 or 77, characterized in that a magnetically conductive material from the group of Fe 3 O 4, Sr-ferrite, NdFeB, SmCo and AlNiCo is used.
79. A method according to any one of claims 76 to 78, characterized in that when using a magnetically anisotropic magnetic conductive material, the Schmelzspinnverfah- ren is at least temporarily performed in the presence of an external magnetic field.
PCT/EP2008/005919 2007-07-18 2008-07-18 System for administering active substances to an organism, devices for use in said type of system and method for producing said type of devices WO2009010303A3 (en)

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