WO2008144355A3 - Stable, self-microemulsifying fenofibrate compositions - Google Patents
Stable, self-microemulsifying fenofibrate compositions Download PDFInfo
- Publication number
- WO2008144355A3 WO2008144355A3 PCT/US2008/063638 US2008063638W WO2008144355A3 WO 2008144355 A3 WO2008144355 A3 WO 2008144355A3 US 2008063638 W US2008063638 W US 2008063638W WO 2008144355 A3 WO2008144355 A3 WO 2008144355A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- fenofibrate
- stable
- component
- liquid
- formulations
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Abstract
Stable oral liquid fenofibrate formulations that include a fenofibrate component and a pharmaceutically acceptable liquid carrier that is present in an amount sufficient to solubilize the fenofibrate and that includes a lipophilic component, a surfactant component, at least one monohydric alcohol, and optionally in some embodiments an aqueous component, wherein the formulation is substantially free of an oily phase. Also included are stable liquid fenofibrate formulations including a prophylactically or therapeutically effective amount of fenofibrate and a liquid carrier present in less than 5 ml that is sufficient to maintain dissolution of the fenofibrate under ambient temperature. Methods of preparing and administering such liquid formulations are also included.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93863207P | 2007-05-17 | 2007-05-17 | |
US60/938,632 | 2007-05-17 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008144355A2 WO2008144355A2 (en) | 2008-11-27 |
WO2008144355A3 true WO2008144355A3 (en) | 2009-06-18 |
Family
ID=39587917
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/063638 WO2008144355A2 (en) | 2007-05-17 | 2008-05-15 | Stable, self-microemulsifying fenofibrate compositions |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008144355A2 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2010261342A1 (en) | 2009-06-19 | 2012-01-19 | Sun Pharma Advanced Research Company Ltd., | Nanodispersion of a drug and process for its preparation |
MX364229B (en) * | 2011-02-04 | 2019-04-17 | Infirst Healthcare Ltd | COMPOSITIONS and METHODS FOR TREATING CARDIOVASCULAR DISEASES. |
EP2878311A1 (en) * | 2013-11-27 | 2015-06-03 | Freund Pharmatec Ltd. | Solubility Enhancement for Hydrophobic Drugs |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999029300A1 (en) * | 1997-12-10 | 1999-06-17 | Rtp Pharma Inc. | Self-emulsifying fenofibrate formulations |
WO2001021154A2 (en) * | 1999-09-21 | 2001-03-29 | Rtp Pharma Inc. | Surface modified particulate compositions of biologically active substances |
US20040005339A1 (en) * | 2002-06-28 | 2004-01-08 | Shojaei Amir H. | Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability |
US20050191343A1 (en) * | 2003-11-26 | 2005-09-01 | Shire Laboratories, Inc. | Micellar systems useful for delivery of lipophilic or hydrophobic compounds |
-
2008
- 2008-05-15 WO PCT/US2008/063638 patent/WO2008144355A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999029300A1 (en) * | 1997-12-10 | 1999-06-17 | Rtp Pharma Inc. | Self-emulsifying fenofibrate formulations |
WO2001021154A2 (en) * | 1999-09-21 | 2001-03-29 | Rtp Pharma Inc. | Surface modified particulate compositions of biologically active substances |
US20040005339A1 (en) * | 2002-06-28 | 2004-01-08 | Shojaei Amir H. | Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability |
US20050191343A1 (en) * | 2003-11-26 | 2005-09-01 | Shire Laboratories, Inc. | Micellar systems useful for delivery of lipophilic or hydrophobic compounds |
Also Published As
Publication number | Publication date |
---|---|
WO2008144355A2 (en) | 2008-11-27 |
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