WO2008144355A3 - Stable, self-microemulsifying fenofibrate compositions - Google Patents

Stable, self-microemulsifying fenofibrate compositions Download PDF

Info

Publication number
WO2008144355A3
WO2008144355A3 PCT/US2008/063638 US2008063638W WO2008144355A3 WO 2008144355 A3 WO2008144355 A3 WO 2008144355A3 US 2008063638 W US2008063638 W US 2008063638W WO 2008144355 A3 WO2008144355 A3 WO 2008144355A3
Authority
WO
WIPO (PCT)
Prior art keywords
fenofibrate
stable
component
liquid
formulations
Prior art date
Application number
PCT/US2008/063638
Other languages
French (fr)
Other versions
WO2008144355A2 (en
Inventor
Ajit S Narang
Lakshmi Rebbapragada
David Delmarre
Mohsin Mohammed
Danchen Gao
Original Assignee
Morton Grove Pharmaceuticals I
Ajit S Narang
Lakshmi Rebbapragada
David Delmarre
Mohsin Mohammed
Danchen Gao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Morton Grove Pharmaceuticals I, Ajit S Narang, Lakshmi Rebbapragada, David Delmarre, Mohsin Mohammed, Danchen Gao filed Critical Morton Grove Pharmaceuticals I
Publication of WO2008144355A2 publication Critical patent/WO2008144355A2/en
Publication of WO2008144355A3 publication Critical patent/WO2008144355A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/216Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers

Abstract

Stable oral liquid fenofibrate formulations that include a fenofibrate component and a pharmaceutically acceptable liquid carrier that is present in an amount sufficient to solubilize the fenofibrate and that includes a lipophilic component, a surfactant component, at least one monohydric alcohol, and optionally in some embodiments an aqueous component, wherein the formulation is substantially free of an oily phase. Also included are stable liquid fenofibrate formulations including a prophylactically or therapeutically effective amount of fenofibrate and a liquid carrier present in less than 5 ml that is sufficient to maintain dissolution of the fenofibrate under ambient temperature. Methods of preparing and administering such liquid formulations are also included.
PCT/US2008/063638 2007-05-17 2008-05-15 Stable, self-microemulsifying fenofibrate compositions WO2008144355A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93863207P 2007-05-17 2007-05-17
US60/938,632 2007-05-17

Publications (2)

Publication Number Publication Date
WO2008144355A2 WO2008144355A2 (en) 2008-11-27
WO2008144355A3 true WO2008144355A3 (en) 2009-06-18

Family

ID=39587917

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/063638 WO2008144355A2 (en) 2007-05-17 2008-05-15 Stable, self-microemulsifying fenofibrate compositions

Country Status (1)

Country Link
WO (1) WO2008144355A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010261342A1 (en) 2009-06-19 2012-01-19 Sun Pharma Advanced Research Company Ltd., Nanodispersion of a drug and process for its preparation
MX364229B (en) * 2011-02-04 2019-04-17 Infirst Healthcare Ltd COMPOSITIONS and METHODS FOR TREATING CARDIOVASCULAR DISEASES.
EP2878311A1 (en) * 2013-11-27 2015-06-03 Freund Pharmatec Ltd. Solubility Enhancement for Hydrophobic Drugs

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029300A1 (en) * 1997-12-10 1999-06-17 Rtp Pharma Inc. Self-emulsifying fenofibrate formulations
WO2001021154A2 (en) * 1999-09-21 2001-03-29 Rtp Pharma Inc. Surface modified particulate compositions of biologically active substances
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
US20050191343A1 (en) * 2003-11-26 2005-09-01 Shire Laboratories, Inc. Micellar systems useful for delivery of lipophilic or hydrophobic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999029300A1 (en) * 1997-12-10 1999-06-17 Rtp Pharma Inc. Self-emulsifying fenofibrate formulations
WO2001021154A2 (en) * 1999-09-21 2001-03-29 Rtp Pharma Inc. Surface modified particulate compositions of biologically active substances
US20040005339A1 (en) * 2002-06-28 2004-01-08 Shojaei Amir H. Formulations of fenofibrate and/or fenofibrate derivatives with improved oral bioavailability
US20050191343A1 (en) * 2003-11-26 2005-09-01 Shire Laboratories, Inc. Micellar systems useful for delivery of lipophilic or hydrophobic compounds

Also Published As

Publication number Publication date
WO2008144355A2 (en) 2008-11-27

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