WO2008144052A3 - Bioluminescent imaging of stem cells - Google Patents
Bioluminescent imaging of stem cells Download PDFInfo
- Publication number
- WO2008144052A3 WO2008144052A3 PCT/US2008/006429 US2008006429W WO2008144052A3 WO 2008144052 A3 WO2008144052 A3 WO 2008144052A3 US 2008006429 W US2008006429 W US 2008006429W WO 2008144052 A3 WO2008144052 A3 WO 2008144052A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- stem cells
- bioluminescent imaging
- mammal
- methods
- stem
- Prior art date
Links
- 210000000130 stem cell Anatomy 0.000 title abstract 6
- 238000003384 imaging method Methods 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
- A61K49/0047—Green fluorescent protein [GFP]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0045—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent agent being a peptide or protein used for imaging or diagnosis in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0097—Cells, viruses, ghosts, red blood cells, viral vectors, used for imaging or diagnosis in vivo
Abstract
Methods and compositions for detecting and localizing light originating from cultured stem cells or stem cells injected into tissue or an animal, especially a mammal, are described. Also disclosed are methods for localization of stem cells in selected regions, as well as for tracking stem cells within the mammal, and for causing stem cell differentiation.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93904607P | 2007-05-18 | 2007-05-18 | |
US60/939,046 | 2007-05-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008144052A2 WO2008144052A2 (en) | 2008-11-27 |
WO2008144052A3 true WO2008144052A3 (en) | 2009-02-05 |
Family
ID=40122249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/006429 WO2008144052A2 (en) | 2007-05-18 | 2008-05-19 | Bioluminescent imaging of stem cells |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008144052A2 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9719146B2 (en) | 2009-09-09 | 2017-08-01 | General Electric Company | Composition and method for imaging stem cells |
CN102517386B (en) * | 2011-12-15 | 2014-02-12 | 浙江省农业科学院 | Lentivirus T vector for promoter analysis, construction method thereof and application thereof |
US9719127B2 (en) | 2012-03-20 | 2017-08-01 | The Regents Of The University Of California | Dual inducible vectors and cell lines |
CN102978164B (en) * | 2012-11-14 | 2014-12-10 | 中国人民解放军第三军医大学第一附属医院 | Channelrhodopsin-2 (ChR2)-green fluorescence protein (GFP) gene engineered nerve stem cell line and construction method thereof |
WO2019195285A1 (en) * | 2018-04-02 | 2019-10-10 | University Of Miami | Ifn-beta reporter system for immortalized primary cells |
JP2022535789A (en) | 2019-05-30 | 2022-08-10 | 490 バイオテック, インコーポレイテッド | Methods of LUX Expression and Use in Cells |
CN116703909B (en) * | 2023-08-07 | 2023-10-27 | 威海海泰电子有限公司 | Intelligent detection method for production quality of power adapter |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5635380A (en) * | 1994-01-18 | 1997-06-03 | Vanderbilt University | Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids |
US20020073441A1 (en) * | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
US20060035373A1 (en) * | 2002-11-01 | 2006-02-16 | Hongbing Zhang | Stem cell libraries |
WO2006096735A2 (en) * | 2005-03-07 | 2006-09-14 | New England Biolabs Inc | Enhancing a luminescent signal |
-
2008
- 2008-05-19 WO PCT/US2008/006429 patent/WO2008144052A2/en active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5635380A (en) * | 1994-01-18 | 1997-06-03 | Vanderbilt University | Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids |
US20020073441A1 (en) * | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
US20060035373A1 (en) * | 2002-11-01 | 2006-02-16 | Hongbing Zhang | Stem cell libraries |
WO2006096735A2 (en) * | 2005-03-07 | 2006-09-14 | New England Biolabs Inc | Enhancing a luminescent signal |
Non-Patent Citations (10)
Also Published As
Publication number | Publication date |
---|---|
WO2008144052A2 (en) | 2008-11-27 |
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