WO2008138337A3 - An oligo peptide synthesis and a cleavage and evaporation apparatus - Google Patents

An oligo peptide synthesis and a cleavage and evaporation apparatus Download PDF

Info

Publication number
WO2008138337A3
WO2008138337A3 PCT/DK2008/000173 DK2008000173W WO2008138337A3 WO 2008138337 A3 WO2008138337 A3 WO 2008138337A3 DK 2008000173 W DK2008000173 W DK 2008000173W WO 2008138337 A3 WO2008138337 A3 WO 2008138337A3
Authority
WO
Grant status
Application
Patent type
Prior art keywords
holder
lines
centre line
centre
drive motor
Prior art date
Application number
PCT/DK2008/000173
Other languages
French (fr)
Other versions
WO2008138337A2 (en )
Inventor
Peter Jepsen
Original Assignee
Alcorlab A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00324Reactor vessels in a multiple arrangement the reactor vessels or wells being arranged in plates moving in parallel to each other
    • B01J2219/00328Movement by linear translation
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00389Feeding through valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00389Feeding through valves
    • B01J2219/00405Sliding valves
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068Means for controlling the apparatus of the process
    • B01J2219/00686Automatic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides

Abstract

An apparatus comprises a drive motor having an output shaft. The apparatus further comprises a holder defining a centre line and comprising a number of receptors for receiving a corresponding number of vessels. The receptors are located on a first circle having its centre on the centre line. The holder has a coupling for connecting the holder to a drive motor, the holder being journalled horizontally and rotatably for stepwise revolving around the centre line powered by the drive motor. The apparatus further comprises a number of synthesis material lines and valves controlling the synthesis material lines, the lines and valves are located relatively to on a lid, each of the lines communicating with a supply container and each of the lines defining a discharge end. The discharge ends are positioned on a second circle having its centre on the centre line for allowing a specific discharge end to be positioned above a specific vessel received in the holder. Vials are optionally located below the vessels.
PCT/DK2008/000173 2007-05-09 2008-05-09 An oligo peptide synthesis and a cleavage and evaporation apparatus WO2008138337A3 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07388033.8 2007-05-09
EP07388033 2007-05-09

Publications (2)

Publication Number Publication Date
WO2008138337A2 true WO2008138337A2 (en) 2008-11-20
WO2008138337A3 true true WO2008138337A3 (en) 2009-10-22

Family

ID=39673411

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2008/000173 WO2008138337A3 (en) 2007-05-09 2008-05-09 An oligo peptide synthesis and a cleavage and evaporation apparatus

Country Status (1)

Country Link
WO (1) WO2008138337A3 (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998057181A1 (en) * 1997-06-10 1998-12-17 Pharmacopeia, Inc. Methods and apparatus for universal fluid exchange
WO1999065602A2 (en) * 1998-06-16 1999-12-23 Northwest Engineering, Inc. Multi-well rotary synthesizer
US20020001849A1 (en) * 1990-03-02 2002-01-03 Copeland Keith G. Automated biological reaction apparatus
US20020028159A1 (en) * 1999-12-13 2002-03-07 Michal Lebl Oligonucleotide synthesizer
US6989133B1 (en) * 1998-12-30 2006-01-24 Mwg-Biotech Ag Device for carrying out chemical reactions
EP1785190A1 (en) * 2005-11-09 2007-05-16 JEPSEN, Peter Synthesis apparatus having rotatable, interchangeable reaction holders

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020001849A1 (en) * 1990-03-02 2002-01-03 Copeland Keith G. Automated biological reaction apparatus
WO1998057181A1 (en) * 1997-06-10 1998-12-17 Pharmacopeia, Inc. Methods and apparatus for universal fluid exchange
WO1999065602A2 (en) * 1998-06-16 1999-12-23 Northwest Engineering, Inc. Multi-well rotary synthesizer
US6989133B1 (en) * 1998-12-30 2006-01-24 Mwg-Biotech Ag Device for carrying out chemical reactions
US20020028159A1 (en) * 1999-12-13 2002-03-07 Michal Lebl Oligonucleotide synthesizer
EP1785190A1 (en) * 2005-11-09 2007-05-16 JEPSEN, Peter Synthesis apparatus having rotatable, interchangeable reaction holders
WO2007054091A1 (en) * 2005-11-09 2007-05-18 Alcorlab A/S An oligo peptide synthesis apparatus
EP1963015A1 (en) * 2005-11-09 2008-09-03 Alcorlab A/S An oligo peptide synthesis apparatus

Also Published As

Publication number Publication date Type
WO2008138337A2 (en) 2008-11-20 application

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