WO2008134734A3 - Encapsulated contrast agents - Google Patents

Encapsulated contrast agents Download PDF

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Publication number
WO2008134734A3
WO2008134734A3 PCT/US2008/062038 US2008062038W WO2008134734A3 WO 2008134734 A3 WO2008134734 A3 WO 2008134734A3 US 2008062038 W US2008062038 W US 2008062038W WO 2008134734 A3 WO2008134734 A3 WO 2008134734A3
Authority
WO
WIPO (PCT)
Prior art keywords
optionally
contrast agents
block
encapsulated
micelle
Prior art date
Application number
PCT/US2008/062038
Other languages
French (fr)
Other versions
WO2008134734A2 (en
Inventor
Habib Skaff
Kurt Breitenkamp
Kevin N Sill
Original Assignee
Intezyne Technologies Inc
Habib Skaff
Kurt Breitenkamp
Kevin N Sill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intezyne Technologies Inc, Habib Skaff, Kurt Breitenkamp, Kevin N Sill filed Critical Intezyne Technologies Inc
Priority to EP08747205A priority Critical patent/EP2152320A2/en
Publication of WO2008134734A2 publication Critical patent/WO2008134734A2/en
Publication of WO2008134734A3 publication Critical patent/WO2008134734A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1818—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
    • A61K49/1887—Agglomerates, clusters, i.e. more than one (super)(para)magnetic microparticle or nanoparticle are aggregated or entrapped in the same maxtrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

The present invention relates to the field of polymer chemistry and more particularly to encapsulated contrast agents and methods for using the same. One embodiment of the present invention provides a micelle having a contrast agent encapsulated therein, comprising a multiblock copolymer which comprises a polymeric hydrophilic block, optionally a poly(amino acid block) that is optionally crosslinkable or crosslinked, and another poly(amino acid) block, characterized in that said micelle has an inner core, optionally a crosslinkable or crosslinked outer core, and a hydrophilic shell.
PCT/US2008/062038 2007-04-30 2008-04-30 Encapsulated contrast agents WO2008134734A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP08747205A EP2152320A2 (en) 2007-04-30 2008-04-30 Encapsulated contrast agents

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US91501407P 2007-04-30 2007-04-30
US60/915,014 2007-04-30
US2541408P 2008-02-01 2008-02-01
US61/025,414 2008-02-01

Publications (2)

Publication Number Publication Date
WO2008134734A2 WO2008134734A2 (en) 2008-11-06
WO2008134734A3 true WO2008134734A3 (en) 2009-06-04

Family

ID=39824499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/062038 WO2008134734A2 (en) 2007-04-30 2008-04-30 Encapsulated contrast agents

Country Status (3)

Country Link
US (1) US8258190B2 (en)
EP (1) EP2152320A2 (en)
WO (1) WO2008134734A2 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7560588B2 (en) 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
WO2008070284A2 (en) 2006-10-16 2008-06-12 Johnnie B. Byrd, Sr. Alzheimer's Center And Research Institute Amyloid beta peptides and methods of uses thereof
US7618944B2 (en) * 2007-03-01 2009-11-17 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
US8956603B2 (en) 2009-02-21 2015-02-17 Sofradim Production Amphiphilic compounds and self-assembling compositions made therefrom
US20100292432A1 (en) * 2009-04-30 2010-11-18 Intezyne Technologies, Incorporated Polymers for polynucleotide encapsulation
US9205155B2 (en) 2009-10-30 2015-12-08 General Electric Company Treating water insoluble nanoparticles with hydrophilic alpha-hydroxyphosphonic acid conjugates, the so modified nanoparticles and their use as contrast agents
GB201010831D0 (en) 2010-06-28 2010-08-11 Ct Angewandte Nanotech Can A micellular combination comprising a nanoparticle and a plurality of surfmer ligands
EP2601270B1 (en) * 2010-08-05 2015-01-14 Council of Scientific & Industrial Research A process for the removal of polymer thermosets from a substrate
EP2452622A1 (en) 2010-11-11 2012-05-16 Philips Intellectual Property & Standards GmbH Colon screening by using magnetic particle imaging
CN102391504B (en) * 2011-09-05 2013-05-15 中国科学院长春应用化学研究所 Copolymer, glucose sensitive micelle, glucose sensitive medicine-carrying micelle and preparation method thereof
CN103755955B (en) * 2014-01-13 2016-04-20 中山大学 A kind of Cationic polyamino acid group carrier material and preparation method thereof
US9629589B2 (en) 2014-08-21 2017-04-25 General Electric Company Moving a component of an imaging system
US20160346408A1 (en) * 2015-05-26 2016-12-01 Intezyne Technologies Iron stabilized micelles as magnetic contrast agents
CN105136834B (en) * 2015-07-14 2017-03-01 上海师范大学 The Fe/Fe that 3,4 dihydroxyphenyl propionic acid are modified3O4Nanoparticle and its preparation method and application
US20230355812A1 (en) * 2020-09-08 2023-11-09 Oregon Health & Science University Stabilized hydrophobic nanoparticles for ultrasound imaging
CN112903635B (en) * 2021-01-12 2022-07-22 西北师范大学 Double-emission CDs/R6G @ ZIF-8 ratiometric fluorescent probe for detecting Fe3+In (1)

Citations (2)

* Cited by examiner, † Cited by third party
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WO2005080032A1 (en) * 2004-02-20 2005-09-01 Kazunori Kataoka Process for producing iron colloid, and iron-colloid-bearing polymer micelle
WO2006107903A2 (en) * 2005-04-01 2006-10-12 Intezyne Technologies, Incorporated Polymeric micelles for drug delivery

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US4650750A (en) * 1982-02-01 1987-03-17 Giese Roger W Method of chemical analysis employing molecular release tag compounds
US4709016A (en) * 1982-02-01 1987-11-24 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5650270A (en) * 1982-02-01 1997-07-22 Northeastern University Molecular analytical release tags and their use in chemical analysis
US5871710A (en) * 1992-09-04 1999-02-16 The General Hospital Corporation Graft co-polymer adducts of platinum (II) compounds
WO2005044224A2 (en) * 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
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EP2348096A3 (en) * 2005-01-04 2011-11-09 Intezyne Technologies Inc. Synthesis of hybrid block copolymers and uses thereof
US20070069040A1 (en) * 2005-08-15 2007-03-29 Lewis Russell H Apparatus and methods for dispensing fluidic or viscous materials
US20070140974A1 (en) 2005-12-15 2007-06-21 General Electric Company Targeted nanoparticles for magnetic resonance imaging
EP1852107A1 (en) 2006-04-19 2007-11-07 Nanobiotix Magnetic nanoparticles compositions and uses thereof
US7560588B2 (en) * 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
US7618944B2 (en) * 2007-03-01 2009-11-17 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
AU2008245404B2 (en) * 2007-04-30 2013-12-05 Intezyne Technologies, Inc. Hybrid block copolymer micelles with mixed stereochemistry for encapsulation of hydrophobic agents
JP2010526091A (en) 2007-04-30 2010-07-29 インテザイン テクノロジーズ， インコーポレイテッド Modification of biological target groups for the treatment of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005080032A1 (en) * 2004-02-20 2005-09-01 Kazunori Kataoka Process for producing iron colloid, and iron-colloid-bearing polymer micelle
WO2006107903A2 (en) * 2005-04-01 2006-10-12 Intezyne Technologies, Incorporated Polymeric micelles for drug delivery

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
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Also Published As

Publication number Publication date
US8258190B2 (en) 2012-09-04
EP2152320A2 (en) 2010-02-17
US20090092554A1 (en) 2009-04-09
WO2008134734A2 (en) 2008-11-06

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