WO2008127283A3 - Engineered metabolic pathways - Google Patents

Engineered metabolic pathways Download PDF

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Publication number
WO2008127283A3
WO2008127283A3 PCT/US2007/021473 US2007021473W WO2008127283A3 WO 2008127283 A3 WO2008127283 A3 WO 2008127283A3 US 2007021473 W US2007021473 W US 2007021473W WO 2008127283 A3 WO2008127283 A3 WO 2008127283A3
Authority
WO
WIPO (PCT)
Prior art keywords
metabolic pathways
engineered metabolic
invention
certain aspects
engineered
Prior art date
Application number
PCT/US2007/021473
Other languages
French (fr)
Other versions
WO2008127283A2 (en
Inventor
Joseph M Jacobson
George Church
Brian M Baynes
Original Assignee
Codon Devices Inc
Joseph M Jacobson
George Church
Brian M Baynes
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US85001706P priority Critical
Priority to US60/850,017 priority
Application filed by Codon Devices Inc, Joseph M Jacobson, George Church, Brian M Baynes filed Critical Codon Devices Inc
Publication of WO2008127283A2 publication Critical patent/WO2008127283A2/en
Publication of WO2008127283A3 publication Critical patent/WO2008127283A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1093General methods of preparing gene libraries, not provided for in other subgroups
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes

Abstract

Certain aspects of the present invention provide methods for designing and engineering metabolic pathways. Aspects of the invention also provide metabolic pathway components and cells containing engineered metabolic pathways. Certain aspects of the invention provide medical, pharmaceutical, industrial, agricultural, environmental, and other Nuses for engineered metabolic pathways of the invention.
PCT/US2007/021473 2006-10-06 2007-10-06 Engineered metabolic pathways WO2008127283A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US85001706P true 2006-10-06 2006-10-06
US60/850,017 2006-10-06

Publications (2)

Publication Number Publication Date
WO2008127283A2 WO2008127283A2 (en) 2008-10-23
WO2008127283A3 true WO2008127283A3 (en) 2009-02-12

Family

ID=39864499

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/021473 WO2008127283A2 (en) 2006-10-06 2007-10-06 Engineered metabolic pathways

Country Status (1)

Country Link
WO (1) WO2008127283A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8192976B2 (en) 2008-12-12 2012-06-05 Celexion, Llc Biological synthesis of difunctional alkanes from carbohydrate feedstocks
US8999679B2 (en) 2008-12-18 2015-04-07 Iti Scotland Limited Method for assembly of polynucleic acid sequences
US8404465B2 (en) 2009-03-11 2013-03-26 Celexion, Llc Biological synthesis of 6-aminocaproic acid from carbohydrate feedstocks
GB2481425A (en) 2010-06-23 2011-12-28 Iti Scotland Ltd Method and device for assembling polynucleic acid sequences

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032514A (en) * 1988-08-08 1991-07-16 Genentech, Inc. Metabolic pathway engineering to increase production of ascorbic acid intermediates
US20020132308A1 (en) * 2000-08-24 2002-09-19 Mpep @ Page 300-M Novel constructs and their use in metabolic pathway engineering
US20070048793A1 (en) * 2005-07-12 2007-03-01 Baynes Brian M Compositions and methods for biocatalytic engineering
WO2007136835A2 (en) * 2006-05-19 2007-11-29 Codon Devices, Inc Methods and cells for creating functional diversity and uses thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032514A (en) * 1988-08-08 1991-07-16 Genentech, Inc. Metabolic pathway engineering to increase production of ascorbic acid intermediates
US20020132308A1 (en) * 2000-08-24 2002-09-19 Mpep @ Page 300-M Novel constructs and their use in metabolic pathway engineering
US20070048793A1 (en) * 2005-07-12 2007-03-01 Baynes Brian M Compositions and methods for biocatalytic engineering
WO2007136835A2 (en) * 2006-05-19 2007-11-29 Codon Devices, Inc Methods and cells for creating functional diversity and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHOTANI G, ET AL.: "THE COMMERCIAL PRODUCTION OF CHEMICALS USING PATHWAY ENGINEERING", BIOCHIMICA ET BIOPHYSICA ACTA, vol. 1543, 2000, pages 434 - 455, XP004279117 *
ISAACS F J ET AL: "RNA synthetic biology", NATURE BIOTECHNOLOGY, NATURE PUBLISHING GROUP, NEW YORK, NY, US, vol. 24, no. 5, 5 May 2006 (2006-05-05), pages 545 - 554, XP002456699, ISSN: 1087-0156 *
KLEEREBEZEM M AND HUGENHOLTZ J: "METABOLIC PATHWAY ENGINEERING IN LACTIC ACID BACTERIA", CURRENT OPINION IN BIOTECHNOLOGY, vol. 14, 2003, pages 232 - 237, XP002502471 *
MEYNIAL-SALLES I ET AL: "New tool for metabolic pathway engineering in Escherichia coli: One-step method to modulate expression of chromosomal genes", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, AMERICAN SOCIETY FOR MICROBIOLOGY, US, vol. 71, no. 4, 1 April 2005 (2005-04-01), pages 2140 - 2144, XP002367550, ISSN: 0099-2240 *

Also Published As

Publication number Publication date
WO2008127283A2 (en) 2008-10-23

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