WO2008115880A3 - Use of leptin for the treatment or prevention of parkinson's disease - Google Patents

Use of leptin for the treatment or prevention of parkinson's disease Download PDF

Info

Publication number
WO2008115880A3
WO2008115880A3 PCT/US2008/057254 US2008057254W WO2008115880A3 WO 2008115880 A3 WO2008115880 A3 WO 2008115880A3 US 2008057254 W US2008057254 W US 2008057254W WO 2008115880 A3 WO2008115880 A3 WO 2008115880A3
Authority
WO
WIPO (PCT)
Prior art keywords
leptin
disease
polypeptide
parkinson
prevention
Prior art date
Application number
PCT/US2008/057254
Other languages
French (fr)
Other versions
WO2008115880A2 (en
Inventor
Wei Zhang
Xin-Yun Lu
Original Assignee
The Board Of Regents Of The University Of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Board Of Regents Of The University Of Texas System filed Critical The Board Of Regents Of The University Of Texas System
Publication of WO2008115880A2 publication Critical patent/WO2008115880A2/en
Publication of WO2008115880A3 publication Critical patent/WO2008115880A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2264—Obesity-gene products, e.g. leptin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Abstract

Disclosed are methods of treating or preventing Parkinson's disease or secondary parkinsonism in a subject, comprising administering to the subject a pharmaceutically effective amount of a leptin polypeptide, leptin transporter polypeptide, leptin receptor polypeptide, or a variant thereof, wherein administering the leptin polypeptide, leptin transporter polypeptide, leptin receptor polypeptide, or variant thereof results in treatment or prevention of Parkinson's disease or secondary parkinsonism in the subject.
PCT/US2008/057254 2007-03-21 2008-03-17 Use of leptin for the treatment or prevention of parkinson's disease WO2008115880A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89620207P 2007-03-21 2007-03-21
US60/896,202 2007-03-21

Publications (2)

Publication Number Publication Date
WO2008115880A2 WO2008115880A2 (en) 2008-09-25
WO2008115880A3 true WO2008115880A3 (en) 2009-09-11

Family

ID=39766725

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/057254 WO2008115880A2 (en) 2007-03-21 2008-03-17 Use of leptin for the treatment or prevention of parkinson's disease

Country Status (1)

Country Link
WO (1) WO2008115880A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8716220B2 (en) 2005-09-07 2014-05-06 Nikolaos Tezapsidis Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta
AU2009248914A1 (en) 2008-05-21 2009-11-26 Neurotez, Inc. Methods for Treating Neurodegenerative Disorders Related to Neurofibrillary Tangles

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002069711A1 (en) * 2001-03-02 2002-09-12 Neuron Therapeutics, Inc. Gene therapy for neurological tissues
US6518235B1 (en) * 1998-03-26 2003-02-11 Yutaka Oomura Methods for improving brain function using leptin or analogs thereof
US20040214855A1 (en) * 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US20070066527A1 (en) * 2005-09-07 2007-03-22 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
WO2007032013A2 (en) * 2005-09-16 2007-03-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compounds for improving nutritional status, cognition and survival

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518235B1 (en) * 1998-03-26 2003-02-11 Yutaka Oomura Methods for improving brain function using leptin or analogs thereof
WO2002069711A1 (en) * 2001-03-02 2002-09-12 Neuron Therapeutics, Inc. Gene therapy for neurological tissues
US20040214855A1 (en) * 2003-04-23 2004-10-28 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US20070066527A1 (en) * 2005-09-07 2007-03-22 Neurotez, Inc. Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology
WO2007032013A2 (en) * 2005-09-16 2007-03-22 Yissum Research Development Company Of The Hebrew University Of Jerusalem Compounds for improving nutritional status, cognition and survival

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SIGNORE ARMANDO P ET AL: "Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials.", JOURNAL OF NEUROCHEMISTRY SEP 2008, vol. 106, no. 5, September 2008 (2008-09-01), pages 1977 - 1990, XP002518720, ISSN: 1471-4159 *
WENG ZHONGFANG ET AL: "Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 47, November 2007 (2007-11-01), pages 34479 - 34491, XP002518719, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
WO2008115880A2 (en) 2008-09-25

Similar Documents

Publication Publication Date Title
WO2011014255A8 (en) Treatment of crohn's disease with laquinimod
WO2008103472A3 (en) Prevention and treatment of synucleinopathic and amyloidogenic disease
GB2463833A (en) Methods and compositions for the treatment of neurological disorders
SG150531A1 (en) Use of meloxicam for the treatment of respiratory diseases in pigs
WO2008022256A3 (en) Methods and compositions for preventing or treating age-related diseases
WO2006035237A3 (en) Methods and compositions relating to alzheimer's disease
IL190150A0 (en) New pyrimidine derivatives and their use in therapy as well as the use of pyrimidine derivatives in the manufacture of a medicament for prevention and/or treatment of alzheimer's disease
WO2007022408A3 (en) Combination methods of saha and targretin for treating cancer
WO2006036770A3 (en) Combination therapy for the treatment of obesity
WO2009067397A3 (en) Treatment for solid tumors
BRPI0816255A2 (en) Pharmaceutical product, use of the product, method for the prophylaxis or treatment of diseases, and pharmaceutically acceptable composition.
WO2007062093A3 (en) Combination therapy for the treatment of cancer comprising a metalloprotease inhibitor
WO2011112867A8 (en) The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas
EP3276004A3 (en) Methods for treating chronic kidney disease
WO2006113978A3 (en) Insulins combinations
WO2006012641A3 (en) Methods for detecting and treating autoimmune disorders
WO2010045417A3 (en) Combination therapies for the treatment of obesity
WO2008012796A3 (en) Pharmaceutical compositions comprising ccl2 and use of same for the treatment of inflammation
WO2007057508A3 (en) Treatment of pain with a combination of an alpha2 -adrenoceptor antagonist such as atipemezole or fipamezoiie and an opioid receptor agonist, such as tramadol
WO2010045522A3 (en) Combination therapies for the treatment of obesity
WO2008077027A3 (en) Treatment of post-menopausal and post-hysterectomy mediated cognitive disorders
WO2006101909A3 (en) Combination therapy for treating or preventing diseases
WO2011022633A3 (en) Method of threating cancer
WO2007069073A3 (en) Pharmaceutical formulations of amyloid inhibiting compounds
WO2008115880A3 (en) Use of leptin for the treatment or prevention of parkinson's disease

Legal Events

Date Code Title Description
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08799628

Country of ref document: EP

Kind code of ref document: A2