WO2008115880A3 - Use of leptin for the treatment or prevention of parkinson's disease - Google Patents
Use of leptin for the treatment or prevention of parkinson's disease Download PDFInfo
- Publication number
- WO2008115880A3 WO2008115880A3 PCT/US2008/057254 US2008057254W WO2008115880A3 WO 2008115880 A3 WO2008115880 A3 WO 2008115880A3 US 2008057254 W US2008057254 W US 2008057254W WO 2008115880 A3 WO2008115880 A3 WO 2008115880A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- leptin
- disease
- polypeptide
- parkinson
- prevention
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2264—Obesity-gene products, e.g. leptin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
Disclosed are methods of treating or preventing Parkinson's disease or secondary parkinsonism in a subject, comprising administering to the subject a pharmaceutically effective amount of a leptin polypeptide, leptin transporter polypeptide, leptin receptor polypeptide, or a variant thereof, wherein administering the leptin polypeptide, leptin transporter polypeptide, leptin receptor polypeptide, or variant thereof results in treatment or prevention of Parkinson's disease or secondary parkinsonism in the subject.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89620207P | 2007-03-21 | 2007-03-21 | |
US60/896,202 | 2007-03-21 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008115880A2 WO2008115880A2 (en) | 2008-09-25 |
WO2008115880A3 true WO2008115880A3 (en) | 2009-09-11 |
Family
ID=39766725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/057254 WO2008115880A2 (en) | 2007-03-21 | 2008-03-17 | Use of leptin for the treatment or prevention of parkinson's disease |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2008115880A2 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8716220B2 (en) | 2005-09-07 | 2014-05-06 | Nikolaos Tezapsidis | Leptin compositions and methods for treating progressive cognitive function disorders resulting from accumulation of neurofibrillary tangles and amyloid beta |
AU2009248914A1 (en) | 2008-05-21 | 2009-11-26 | Neurotez, Inc. | Methods for Treating Neurodegenerative Disorders Related to Neurofibrillary Tangles |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002069711A1 (en) * | 2001-03-02 | 2002-09-12 | Neuron Therapeutics, Inc. | Gene therapy for neurological tissues |
US6518235B1 (en) * | 1998-03-26 | 2003-02-11 | Yutaka Oomura | Methods for improving brain function using leptin or analogs thereof |
US20040214855A1 (en) * | 2003-04-23 | 2004-10-28 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
US20070066527A1 (en) * | 2005-09-07 | 2007-03-22 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
WO2007032013A2 (en) * | 2005-09-16 | 2007-03-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds for improving nutritional status, cognition and survival |
-
2008
- 2008-03-17 WO PCT/US2008/057254 patent/WO2008115880A2/en active Application Filing
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6518235B1 (en) * | 1998-03-26 | 2003-02-11 | Yutaka Oomura | Methods for improving brain function using leptin or analogs thereof |
WO2002069711A1 (en) * | 2001-03-02 | 2002-09-12 | Neuron Therapeutics, Inc. | Gene therapy for neurological tissues |
US20040214855A1 (en) * | 2003-04-23 | 2004-10-28 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
US20070066527A1 (en) * | 2005-09-07 | 2007-03-22 | Neurotez, Inc. | Leptin as an anti-amyloidogenic biologic and methods for delaying the onset and reducing Alzheimer's disease-like pathology |
WO2007032013A2 (en) * | 2005-09-16 | 2007-03-22 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compounds for improving nutritional status, cognition and survival |
Non-Patent Citations (2)
Title |
---|
SIGNORE ARMANDO P ET AL: "Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials.", JOURNAL OF NEUROCHEMISTRY SEP 2008, vol. 106, no. 5, September 2008 (2008-09-01), pages 1977 - 1990, XP002518720, ISSN: 1471-4159 * |
WENG ZHONGFANG ET AL: "Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 282, no. 47, November 2007 (2007-11-01), pages 34479 - 34491, XP002518719, ISSN: 0021-9258 * |
Also Published As
Publication number | Publication date |
---|---|
WO2008115880A2 (en) | 2008-09-25 |
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