WO2008089270A3 - Flow chamber device for neutralization of cancer cells - Google Patents

Flow chamber device for neutralization of cancer cells Download PDF

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Publication number
WO2008089270A3
WO2008089270A3 PCT/US2008/051211 US2008051211W WO2008089270A3 WO 2008089270 A3 WO2008089270 A3 WO 2008089270A3 US 2008051211 W US2008051211 W US 2008051211W WO 2008089270 A3 WO2008089270 A3 WO 2008089270A3
Authority
WO
WIPO (PCT)
Prior art keywords
neutralization
cancer cells
flow chamber
chamber device
cancer cell
Prior art date
Application number
PCT/US2008/051211
Other languages
French (fr)
Other versions
WO2008089270A2 (en
Inventor
Michael R. King
Jane Liesveld
Kuldeepsinh Rana
Original Assignee
University Of Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Rochester filed Critical University Of Rochester
Publication of WO2008089270A2 publication Critical patent/WO2008089270A2/en
Publication of WO2008089270A3 publication Critical patent/WO2008089270A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • C12N5/0093—Purging against cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells

Abstract

The present invention relates to methods and apparatuses for neutralizing cancer cells. In particular, the invention relates to separating of cancer cell type from a mixture of different cell types based on the differential rolling property of cancer cell on a substrate coated with a first molecules that exhibits adhesive property with the particular cell type and neutralizing the cancer cell by a second molecule that is also coated on the substrate. This technology is adaptable for use in vivo, in vitro, or ex vivo tumor neutralization.
PCT/US2008/051211 2007-01-16 2008-01-16 Flow chamber device for neutralization of cancer cells WO2008089270A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88037907P 2007-01-16 2007-01-16
US60/880,379 2007-01-16

Publications (2)

Publication Number Publication Date
WO2008089270A2 WO2008089270A2 (en) 2008-07-24
WO2008089270A3 true WO2008089270A3 (en) 2011-07-21

Family

ID=39636687

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/051211 WO2008089270A2 (en) 2007-01-16 2008-01-16 Flow chamber device for neutralization of cancer cells

Country Status (1)

Country Link
WO (1) WO2008089270A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008131301A1 (en) * 2007-04-18 2008-10-30 Massachusetts Institute Of Technology Surfaces, methods and devices employing cell rolling
WO2009043057A2 (en) 2007-09-27 2009-04-02 Massachusetts Institute Of Technology Cell rolling separation
KR102513866B1 (en) * 2014-03-07 2023-03-23 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 Biomimetic microfluid device for capturing circulating tumor cells

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6365362B1 (en) * 1998-02-12 2002-04-02 Immunivest Corporation Methods and reagents for the rapid and efficient isolation of circulating cancer cells
US6433147B1 (en) * 1997-01-28 2002-08-13 Human Genome Sciences, Inc. Death domain containing receptor-4
US20040191246A1 (en) * 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
WO2006078994A2 (en) * 2005-01-21 2006-07-27 University Of Rochester Continuous flow chamber device for separation, concentration, and/or purification of cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6433147B1 (en) * 1997-01-28 2002-08-13 Human Genome Sciences, Inc. Death domain containing receptor-4
US6365362B1 (en) * 1998-02-12 2002-04-02 Immunivest Corporation Methods and reagents for the rapid and efficient isolation of circulating cancer cells
US20040191246A1 (en) * 2003-02-26 2004-09-30 Connelly Patrick R. Process for in vivo treatment of specific biological targets in bodily fluid
WO2006078994A2 (en) * 2005-01-21 2006-07-27 University Of Rochester Continuous flow chamber device for separation, concentration, and/or purification of cells

Also Published As

Publication number Publication date
WO2008089270A2 (en) 2008-07-24

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