WO2008088900A3 - Polymorphic forms of rimonabant base and processes for preparation thereof - Google Patents

Polymorphic forms of rimonabant base and processes for preparation thereof Download PDF

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Publication number
WO2008088900A3
WO2008088900A3 PCT/US2008/000726 US2008000726W WO2008088900A3 WO 2008088900 A3 WO2008088900 A3 WO 2008088900A3 US 2008000726 W US2008000726 W US 2008000726W WO 2008088900 A3 WO2008088900 A3 WO 2008088900A3
Authority
WO
WIPO (PCT)
Prior art keywords
rimonabant
rimonabant base
processes
preparation
crystalline
Prior art date
Application number
PCT/US2008/000726
Other languages
French (fr)
Other versions
WO2008088900A2 (en
WO2008088900A9 (en
Inventor
Michal Rafilovich
Revital Lifshitz-Liron
Judith Aronhime
Marina Kalujny
Eli Lancry
Yaron Shmuely
Original Assignee
Teva Pharma
Michal Rafilovich
Revital Lifshitz-Liron
Judith Aronhime
Marina Kalujny
Eli Lancry
Yaron Shmuely
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US88124207P priority Critical
Priority to US60/881,242 priority
Priority to US89910107P priority
Priority to US60/899,101 priority
Priority to US60/903,198 priority
Priority to US90319807P priority
Priority to US90398707P priority
Priority to US60/903,987 priority
Priority to US91897807P priority
Priority to US60/918,978 priority
Priority to US60/921,050 priority
Priority to US92105007P priority
Priority to US60/923,477 priority
Priority to US92347707P priority
Priority to US61/007,139 priority
Priority to US713907P priority
Application filed by Teva Pharma, Michal Rafilovich, Revital Lifshitz-Liron, Judith Aronhime, Marina Kalujny, Eli Lancry, Yaron Shmuely filed Critical Teva Pharma
Publication of WO2008088900A2 publication Critical patent/WO2008088900A2/en
Publication of WO2008088900A9 publication Critical patent/WO2008088900A9/en
Publication of WO2008088900A3 publication Critical patent/WO2008088900A3/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system

Abstract

The present invention provides process for crystalline forms of Rimonabant base, including processes that prepare crystalline forms of Rimonabant base. Also provided is a crystalline Rimonabant base form I having a substantially reduced residual solvent content, including processes that prepare such crystalline Rimonabant form I. These crystalline forms of Rimonabant base may be in a pharmaceutical compositions further comprising at least one pharmaceutically acceptable excipient.
PCT/US2008/000726 2007-01-18 2008-01-18 Polymorphic forms of rimonabant base and processes for preparation thereof WO2008088900A2 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
US88124207P true 2007-01-18 2007-01-18
US60/881,242 2007-01-18
US89910107P true 2007-02-01 2007-02-01
US60/899,101 2007-02-01
US90319807P true 2007-02-22 2007-02-22
US60/903,198 2007-02-22
US90398707P true 2007-02-27 2007-02-27
US60/903,987 2007-02-27
US91897807P true 2007-03-19 2007-03-19
US60/918,978 2007-03-19
US92105007P true 2007-03-29 2007-03-29
US60/921,050 2007-03-29
US92347707P true 2007-04-12 2007-04-12
US60/923,477 2007-04-12
US713907P true 2007-12-10 2007-12-10
US61/007,139 2007-12-10

Publications (3)

Publication Number Publication Date
WO2008088900A2 WO2008088900A2 (en) 2008-07-24
WO2008088900A9 WO2008088900A9 (en) 2008-09-18
WO2008088900A3 true WO2008088900A3 (en) 2008-10-30

Family

ID=39494313

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/000726 WO2008088900A2 (en) 2007-01-18 2008-01-18 Polymorphic forms of rimonabant base and processes for preparation thereof

Country Status (1)

Country Link
WO (1) WO2008088900A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009153804A1 (en) * 2008-06-16 2009-12-23 Cadila Healthcare Limited Process for preparing form i of rimonabant

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624941A (en) * 1992-06-23 1997-04-29 Sanofi Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present
WO2003040105A1 (en) * 2001-11-08 2003-05-15 Sanofi-Synthelabo Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
WO2006021652A1 (en) * 2004-07-22 2006-03-02 Sanofi-Aventis Method for preparing n-piperidino-1,5-diphenylpyrazole-3-carboxamide derivatives
EP1743888A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Carbonyl substituted pyrazoline compounds, their preparation and use as CB1 receptor modulators
WO2007103711A2 (en) * 2006-03-01 2007-09-13 Dr. Reddy's Laboratories Ltd. Polymorphic forms of rimonabant
WO2007121466A2 (en) * 2006-04-18 2007-10-25 Dr. Reddy's Laboratories Ltd. Process for preparing rimonabant
WO2008032330A2 (en) * 2006-09-11 2008-03-20 Hetero Drugs Limited Improved process for rimonabant
WO2008044153A2 (en) * 2006-08-29 2008-04-17 Medichem, S.A. Improved method for synthesizing rimonabant

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624941A (en) * 1992-06-23 1997-04-29 Sanofi Pyrazole derivatives, method of preparing them and pharmaceutical compositions in which they are present
WO2003040105A1 (en) * 2001-11-08 2003-05-15 Sanofi-Synthelabo Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same
WO2006021652A1 (en) * 2004-07-22 2006-03-02 Sanofi-Aventis Method for preparing n-piperidino-1,5-diphenylpyrazole-3-carboxamide derivatives
EP1743888A1 (en) * 2005-07-15 2007-01-17 Laboratorios Del Dr. Esteve, S.A. Carbonyl substituted pyrazoline compounds, their preparation and use as CB1 receptor modulators
WO2007103711A2 (en) * 2006-03-01 2007-09-13 Dr. Reddy's Laboratories Ltd. Polymorphic forms of rimonabant
WO2007121466A2 (en) * 2006-04-18 2007-10-25 Dr. Reddy's Laboratories Ltd. Process for preparing rimonabant
WO2008044153A2 (en) * 2006-08-29 2008-04-17 Medichem, S.A. Improved method for synthesizing rimonabant
WO2008032330A2 (en) * 2006-09-11 2008-03-20 Hetero Drugs Limited Improved process for rimonabant

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SELTZMAN HERBERT H ET AL: "Tritiation of SR141716 by metalation-iodination-reduction: tritium-proton noe study", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 45, 1 January 2002 (2002-01-01), pages 59 - 70, XP002432372, ISSN: 0362-4803 *

Also Published As

Publication number Publication date
WO2008088900A9 (en) 2008-09-18
WO2008088900A2 (en) 2008-07-24

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