WO2008084005A1 - Spiropiperidine glycinamide derivatives - Google Patents
Spiropiperidine glycinamide derivatives Download PDFInfo
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- WO2008084005A1 WO2008084005A1 PCT/EP2008/050028 EP2008050028W WO2008084005A1 WO 2008084005 A1 WO2008084005 A1 WO 2008084005A1 EP 2008050028 W EP2008050028 W EP 2008050028W WO 2008084005 A1 WO2008084005 A1 WO 2008084005A1
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- piperidin
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- 0 *C(c1c(*)c(*)c(*)c(*)c1S)N Chemical compound *C(c1c(*)c(*)c(*)c(*)c1S)N 0.000 description 8
- NQCPWIBLOQTVAP-UHFFFAOYSA-N C(c1ccccc1)N(CC1)CCC11OCc2ccccc12 Chemical compound C(c1ccccc1)N(CC1)CCC11OCc2ccccc12 NQCPWIBLOQTVAP-UHFFFAOYSA-N 0.000 description 1
- SHRBNEKHBHYNNZ-UHFFFAOYSA-N CC(C(c(cc1)ccc1Cl)NCC(N(CC1)CCC11OCc2c1cccc2)=O)(c1cnccc1)O Chemical compound CC(C(c(cc1)ccc1Cl)NCC(N(CC1)CCC11OCc2c1cccc2)=O)(c1cnccc1)O SHRBNEKHBHYNNZ-UHFFFAOYSA-N 0.000 description 1
- IDTLHIHUTMHHNP-UHFFFAOYSA-N CC(C)(C(N(CC1)CCC11OCc2c1cccc2)=O)NC(c1ccccc1)c1ccccc1 Chemical compound CC(C)(C(N(CC1)CCC11OCc2c1cccc2)=O)NC(c1ccccc1)c1ccccc1 IDTLHIHUTMHHNP-UHFFFAOYSA-N 0.000 description 1
- DLWUCJJEDAUTGE-CQSZACIVSA-N CC(C)(C)OC(N1[C@@H](CC(c2cc(Cl)ccc2)=O)CCC1)=O Chemical compound CC(C)(C)OC(N1[C@@H](CC(c2cc(Cl)ccc2)=O)CCC1)=O DLWUCJJEDAUTGE-CQSZACIVSA-N 0.000 description 1
- JXVRQJHPRYZPOF-LLVKDONJSA-N C[C@H](C(N(CC1)CCC11OCc2ccccc12)=O)N Chemical compound C[C@H](C(N(CC1)CCC11OCc2ccccc12)=O)N JXVRQJHPRYZPOF-LLVKDONJSA-N 0.000 description 1
- FQPZWNGVHQVZLN-UHFFFAOYSA-N NC(CCC(O)=O)c(cc1)ccc1Cl Chemical compound NC(CCC(O)=O)c(cc1)ccc1Cl FQPZWNGVHQVZLN-UHFFFAOYSA-N 0.000 description 1
- YJRJMYZOAPKLFB-UHFFFAOYSA-N NC(c(cc1)ccc1F)c1cccc(C(F)(F)F)c1 Chemical compound NC(c(cc1)ccc1F)c1cccc(C(F)(F)F)c1 YJRJMYZOAPKLFB-UHFFFAOYSA-N 0.000 description 1
- GCQGGBKEXLAECL-UHFFFAOYSA-N O=C(CNC(c1ccccc1)c1cccc(Cl)c1)N(CC1)CCC11OCc2ccccc12 Chemical compound O=C(CNC(c1ccccc1)c1cccc(Cl)c1)N(CC1)CCC11OCc2ccccc12 GCQGGBKEXLAECL-UHFFFAOYSA-N 0.000 description 1
- HVBSJHPDXXGWBB-UHFFFAOYSA-N O=C(CNC(c1ncc[s]1)c(cc1)cc(Cl)c1Cl)N(CC1)CCC11OCc2ccccc12 Chemical compound O=C(CNC(c1ncc[s]1)c(cc1)cc(Cl)c1Cl)N(CC1)CCC11OCc2ccccc12 HVBSJHPDXXGWBB-UHFFFAOYSA-N 0.000 description 1
- VUGARIRJGQJOIH-RCZVLFRGSA-N OC[C@@H](CCC1)N1C([C@@H](c1ccccc1)NCC(N(CC1)CCC11OCc2c1cccc2)=O)=O Chemical compound OC[C@@H](CCC1)N1C([C@@H](c1ccccc1)NCC(N(CC1)CCC11OCc2c1cccc2)=O)=O VUGARIRJGQJOIH-RCZVLFRGSA-N 0.000 description 1
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- the present invention is concerned with novel spiropiperidine glycinamide derivatives as Via receptor antagonists, their manufacture, pharmaceutical compositions containing them and their use as medicaments.
- the active compounds of the present invention are useful in the prevention and/or treatment of anxiety and depressive disorders and other diseases.
- X and Y are selected from the combinations of
- X is CH 2 , and Y is O,
- X is O, and Y is CH 2 ,
- X is NR 7
- X is NR 7
- Y is CH 2
- R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, halo, Ci- 6 -alkyl, Ci- 6 -haloalkyl,
- Ci- 6 -alkoxy, or Ci- 6 -haloalkoxy are each independently hydrogen or methyl; R 6 and R 6 are each independently hydrogen or methyl; R 7 is hydrogen, C 1-6 -alkyl, -C(O)O-C 1-6 -alkyl, or -C(O)O-C 2 - 6 -alkenyl; R 8 , R 8 , R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen,
- Ci- 4 -alkyl optionally substituted by CN or OH, Ci- 4 -haloalkyl, Ci- 4 -alkoxy, Ci- 4 -haloalkoxy, or hydroxy;
- R 11 is hydrogen
- Ci- 6 -alkyl optionally substituted by CN, OH or halogen, -(CRR n ) m -R m , wherein R 1 and R 11 are independently from each other H,
- Ci- 4 -alkyl optionally substituted with OH, or one R 1 and one R 11 together with the carbon atom to which they are bound form a 3 to 5-membered cycloalkyl, wherein m is from 0 to 4, wherein R 111 is phenyl, naphthyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7- membered cycloalkyl, which are optionally substituted by one or more A,
- Ci- 6 -alkyl optionally substituted with OH, or CN, Ci- 6 -alkoxy, hydroxy, phenyl, naphthyl, benzyl, -Obenzyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7- membered cycloalkyl, which are optionally substituted by one or more
- R g , R and R J are each independently selected from hydrogen
- Ci- 6 -alkyl phenyl or 5- to 6-membered heteroaryl, optionally substituted with one or more A,
- R a and R are each independently hydrogen or Ci- 6 -alkyl
- R c is phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl
- R d is phenyl or 5- to 6-membered heteroaryl
- R e is Ci-6-alkyl, Ci-6-alkoxy, phenyl, or 5- to 6-membered heteroaryl
- R 8 or R 8 together with R 11 and the atoms to which they are bound form a 5- membered carbocycle, optionally anellated with benzo, - A - wherein the benzo is optionally substituted with one, two or three substituents selected from halo, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6-alkoxy, Ci-6-haloalkoxy, nitro, hydroxy, or cyano, or a pharmaceutically acceptable salt thereof.
- the compounds of formula (I) can be manufactured by the methods given below, by the methods given in the examples or by analogous methods. Appropriate reaction conditions for the individual reaction steps are known to a person skilled in the art. Starting materials are either commercially available or can be prepared by methods analogous to the methods given below, by methods described in references cited in the text or in the examples, or by methods known in the art.
- the compounds of formula (I) possess pharmaceutical activity, in particular they are modulators of Via receptor activity. More particular, the compounds are antagonists of the Via receptor.
- Vasopressin is a 9 amino acid peptide mainly produced by the paraventricular nucleus of the hypothalamus. Three vasopressin receptors, all belonging to the class I G- protein coupled receptors, are known.
- the Via receptor is expressed in the brain, liver, vascular smooth muscle, lung, uterus and testis, the VIb or V3 receptor is expressed in the brain and pituitary gland, the V2 receptor is expressed in the kidney where it regulates water excretion and mediates the antidiuretic effects of vasopressin.
- vasopressin acts as a neurohormone and stimulates vasoconstriction, glycogenolysis and antidiuresis.
- vasopressin acts as a neuromodulator and is elevated in the amygdala during stress ( Ebner, K., C. T. Wotjak, et al. (2002). "Forced swimming triggers vasopressin release within the amygdala to modulate stress-coping strategies in rats.” Eur I Neurosci 15(2): 384-8).
- the Via receptor is extensively expressed in the brain and particularly in limbic areas like the amygdala, lateral septum and hippocampus which are playing an important role in the regulation of anxiety.
- the Via receptor is also mediating the cardiovascular effects of vasopressin in the brain by centrally regulating blood pressure and heart rate in the solitary tract nucleus (Michelini, L. C. and M. Morris (1999). "Endogenous vasopressin modulates the cardiovascular responses to exercise.” Ann N Y Acad Sci 897: 198-211). In the periphery it induces the contraction of vascular smooth muscles and chronic inhibition of the Via receptor improves hemodynamic parameters in myocardial infarcted rats ( Van Kerckhoven, R., I. Lankhuizen, et al. (2002). "Chronic vasopressin V(IA) but not V(2) receptor antagonism prevents heart failure in chronically infarcted rats.” Eur T Pharmacol 449(1-2): 135-41).
- Via receptor modulators and in particular as Via receptor antagonists.
- Such antagonists are useful as therapeutics in the conditions of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders.
- the preferred indications with regard to the present invention are the treatment of anxiety and depressive disorders.
- alkyl refers to a branched or straight- chain monovalent saturated hydrocarbon radical.
- the term "Ci- 6 -alkyl” denotes a saturated straight- or branched-chain hydrocarbon group containing from 1 to 6 carbon atoms, for example, methyl, ethyl, n-propyl, isopropyl, n- butyl, isobutyl, tert-but ⁇ , the isomeric pentyls and the like.
- a preferred sub-group of C 1 ⁇ - alkyl is Q-4-alkyl, i.e. with 1 - 4 carbon atoms.
- alkylene refers to a linear or branched saturated divalent hydrocarbon radical.
- Ci-6-alkylene means a linear saturated divalent hydrocarbon radical of one to six carbon atoms or a branched saturated divalent hydrocarbon radical of three to six carbon atoms, e.g. methylene, ethylene, 2,2- dimethylethylene, n-propylene, 2-methylpropylene, 1-methyl-ethylene, 2-methyl-ethylene and the like.
- alkoxy and “Ci-6-alkoxy” refers to the group R'-O-, wherein R' is alkyl or Ci-6-alkyl as defined above.
- alkoxy groups are methoxy, ethoxy, n-propoxy, isopropoxy, n-butoxy, tert-butoxy, sec-butoxy and the like.
- a preferred sub-group of Ci-6-alkoxy, and still more preferred alkoxy groups are methoxy and/or ethoxy.
- thioalkyl and "Ci- 6 -thioalkyl” refers to the group R'-S-, wherein R' is alkyl or Ci-6-alkyl as defined above.
- -S(OV 2 C 1- O- alkyl hence refers to the residues -S-Ci- 6 -alkyl, -S(O)-Ci- 6 -alkyl, and -S(O) 2 -Ci- 6 -alkyl wherein Ci-6-alkyl is as defined above.
- -(CH 2 ) x -S(0)o- 2 C 1- 6-alkyl relates to the residues -(CH 2 ) x -S-Ci- 6 -alkyl, -(CH 2 ) x -S(O)-Ci- 6 -alkyl, and -(CH 2 ) ⁇ -S(O) 2 -C 1-6 - alkyl wherein x in -(CH 2 ) X - is from 0, 1, 2, 3, or 4.
- Ci-6-alkyl substituted by OH is synonymous with "Ci-6-hydroxyalkyl” or "hydroxy-Ci-6-alkyl” and means a Ci-6-alkyl group as defined above wherein at least one of the hydrogen atoms of the alkyl group is replaced by a hydroxy group.
- Ci-6-alkyl substituted by CN is synonymous with “Ci-6-cyanoalkyl” or
- cyano-Ci-6-alkyl and means a Ci-6-alkyl group as defined above wherein at least one of the hydrogen atoms of the alkyl group is replaced by a CN group.
- halo or halogen refers to fluorine (F), chlorine (Cl), bromine (Br) and iodine (I) with fluorine, chlorine and bromine being preferred.
- halo-Ci- 6 -alkyl is synonymous with "Ci- 6 -haloalkyl” or "Ci- 6 -alkyl substitutied by halo” and means a Ci-6-alkyl group as defined above wherein at least one of the hydrogen atoms of the alkyl group is replaced by a halogen atom, preferably fluoro or chloro, most preferably fluoro.
- halo-Ci-6-alkyl examples include but are not limited to methyl, ethyl, propyl, isopropyl, isobutyl, sec-butyl, tert-butyl, pentyl or n-hexyl substituted by one or more Cl, F, Br or I atom(s) as well as those groups specifically illustrated by the examples herein below.
- halo-Ci-6-alkyl groups are difluoro- or trifluoro-methyl or -ethyl.
- halo-Ci-6-alkoxy is synonymous with "Ci-6-haloalkoxy” or "Ci-6-alkoxy substitutied by halo” and means a Ci-6-alkoxy group as defined above wherein at least one of the hydrogen atoms of the alkoxy group is replaced by a halogen atom, preferably fluoro or chloro, most preferably fluoro.
- halogenated alkoxy groups are difluoro- or trifluoro-methoxy or -ethoxy.
- C 2 - 6 -alkenyl alone or in combination, denotes a straight- chain or branched hydrocarbon residue of 2 to 6 carbon atoms comprising at least one double bond.
- Examples of the preferred alkenyl groups are ethenyl, propen-1-yl, propen-2-yl (allyl), buten-1-yl, buten-2-yl, buten-3-yl, penten-1-yl, penten-2-yl, penten-3-yl, penten-4- yl, hexen-1-yl, hexen-2-yl, hexen-3-yl, hexen-4-yl and hexen-5-yl, as well as those specifically illustrated by the examples herein below.
- 5 or 6 membered heteroaryl means a monovalent aromatic ring of 5 or 6 ring atoms as ring members containing one, two, three or four ring heteroatoms selected from N, O, or S, the rest being carbon atoms, whereby one, two or three heteroatoms are preferred, and one or two heteroatoms are even more preferred.
- the attachment point of the monovalent heteroaryl shall be a carbon atom.
- heteroaryl moieties include, but are not limited to pyrrolyl, pyrazolyl, imidazolyl, furanyl (synonymous to furyl), thiophenyl (synonymous to thienyl), oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl.
- 5 or 6-membered heteroaryl are optionally substituted with one or more substituents. These optional substitutents include the substituents as described herein, in particular the substituents defined herein as "A".
- preferred subsitituents are halo, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6-alkoxy, C 1 ⁇ - haloalkoxy, cyano, Ci- 6 -cyanoalkyl, -CH 2 OCH 3 , -S(O) 2 -Ci- 6 -alkyl, Ci- 6 -hydroxyalkyl, -C(O)OCi- 6 -alkyl, -NHC(O)-C 1-6 -alkyl, -NHS(O) 2 C 1-6 -alkyl, -C(O)N(C 1-6 -alkyl) 2 , -C(O)NH(Ci- 6 -alkyl), -S(O) 2 N(Ci- 6 -alkyl) 2 , or -S(O) 2 NH(C 1-6 -alkyl). Particularly preferred are halo, -CH 2 OH and Ci-6-alkyl.
- 9- to 10-membered bicyclic heteroaryl means a monovalent aromatic bicyclic ring of 9 or 10 ring atoms as ring members containing one, two, three or four ring heteroatoms selected from N, O, or S, the rest being carbon atoms, whereby one, two or three heteroatoms are preferred, and one or two heteroatoms are even more preferred.
- the attachment point of the monovalent heteroaryl shall be a carbon atom.
- 9- to 10-membered bicyclic heteroaryl moieties include, but are not limited to indolyl, benzoimidazolyl, indazolyl, benzooxazolyl, lH-pyrrolo[2,3-c]pyridinyl, benzothienyl, benzofuranyl, purinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, cinnolinyl, phthalazinyl, or pteridinyl.
- Preferred 9- to 10-membered bicyclic heteroaryl are benzofuranyl, benzothienyl, indolyl, benzoimidazolyl, indazolyl, or benzooxazolyl. More preferred is benzofuranyl.
- the 9- to 10-membered bicyclic heteroaryl group is optionally substituted with one or more substituents. These optional substitutents include the substituents as described herein, in particular the substituents defined herein as "A".
- preferred subsitituents are halo, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6-alkoxy, Ci-6- haloalkoxy, cyano, Ci-6-cyanoalkyl, -CH 2 OCH 3 , -S(O) 2 -Ci-6-alkyl, Ci-6-hydroxyalkyl, -C(O)OCi- 6 -alkyl, -NHC(O) -Ci- 6 -alkyl, -NHS(O) 2 Ci- 6 -alkyl, -C(O)N(Ci- 6 -alkyl) 2) -C(O)NH(Ci- 6 -alkyl), -S(O) 2 N(Ci- 6 -alkyl) 2) or -S(O) 2 NH(Ci- 6 -alkyl). Particularly preferred are halo, -CH 2 OH and Ci-6-alkyl.
- aromatic in the above sense means the presence of an electron sextet in the ring, according to H ⁇ ckel's rule.
- heterocycloalkyl means a monovalent saturated ring, consisting of one ring of 3 to 7, preferably from 4 to 6 atoms as ring members, including one, two, three or four heteroatoms chosen from nitrogen, oxygen or sulfur, the rest being carbon atoms, whereby one, two or three heteroatoms are preferred, and one or two heteroatoms are even more preferred. It is understood that the number of heteroatoms depends on the ring size, i.e. 3 and 4-membered heterocycloalkyl preferably contain one heteroatom, 5 to 7- membered heterocycloalkyl preferably contain one, two or three heteroatoms, and even more preferably one or two heteroatoms.
- heterocyclic moieties include, but are not limited to, oxiranyl, thiiranyl, aziridinyl, oxetanyl, azetidinyl, tetrahydro-furanyl, tetrahydro-thiophenyl (synonymous with tetrahydro-thienyl), pyrrolidinyl, pyrazolidinyl, imidazolidinyl, oxazidinyl, isoxazidinyl, thiazolidinyl, isothiazolidinyl, piperidinyl, piperazidinyl, morpholinyl, or tetrahydropyranyl, each of which is optionally substituted as described herein.
- 3 to 7-membered heterocycloalkyl are optionally substituted with one or more substituents as defined herein, in particular as defined herein as "A".
- Particularly preferred are O, hydroxy, Ci- 6 -alkyl, -S(O) 2 -Ci- 6 -alkyl, Ci-6-hydroxyalkyl, -C(O)OCi- 6 -alkyl, -N(C 1-6 -alkyl) 2 , -S(O) 2 N(Ci- 6 -alkyl) 2 , or -C(O)N(d- 6 -alkyl) 2 .
- one or more substituents indicates that in principle every position in the aryl (in particular phenyl), heteroaryl, heterocycloalkyl and cycloalkyl residue may bear such a substituent.
- the pentafluorophenyl residue may be mentioned as an example.
- one, two, or three substituents are preferred.
- 9- to 10-membered bicyclic heteroaryl rings one, two or three substituents are preferred.
- 5 to 6-membered saturated rings one, two three or four substituents are preferred.
- 3 to 4-membered rings one or two substituents are preferred.
- pharmaceutically acceptable acid addition salt or “pharmaceutically acceptable salt” embraces salts with inorganic and organic acids, such as hydrochloric acid, nitric acid, sulfuric acid, phosphoric acid, citric acid, formic acid, fumaric acid, maleic acid, acetic acid, succinic acid, tartaric acid, methane-sulfonic acid, p-toluenesulfonic acid and the like.
- the invention further comprises individual optical isomers of the compounds herein as well as racemic and non-racemic mixtures thereof.
- X and Y are selected from the combinations of
- X is CH 2 , and Y is O,
- X is O, and Y is CH 2 ,
- X is NR 7
- X is NR 7
- Y is CH 2
- X-Y is -CH 2 CH 2 -, or
- R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, halo, Ci- 6 -alkyl, Ci- 6 -haloalkyl,
- Ci- 6 -alkoxy Ci- 6 -haloalkoxy
- R 5 and R 5 are each independently hydrogen or methyl;
- R 6 and R 6 are each independently hydrogen or methyl;
- R 7 is hydrogen, C 1-6 -alkyl, -C(O)O-C 1-6 -alkyl, or -C(O)O-C 2 - 6 -alkenyl;
- R 8 , R 8 , R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen,
- Ci- 4 -alkyl optionally substituted by CN or OH, Ci- 4 -haloalkyl,
- R 11 is hydrogen, Ci- 6 -alkyl, optionally substituted by CN, OH or halogen,
- R 1 and R 11 are independently from each other H, OH, Ci- 4 -alkyl, optionally substituted with OH, or one R 1 and one R 11 together with the carbon atom to which they are bound form a 3 to 5-membered cycloalkyl, wherein m is from 0 to 4, wherein R 111 is phenyl, naphthyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7- membered cycloalkyl, which are optionally substituted by one or more A, -C(O) -R lv , wherein R lv is
- Ci- 6 -alkyl optionally substituted with OH, or CN, Ci- 6 -alkoxy, hydroxy, phenyl, naphthyl, benzyl, -Obenzyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7- membered cycloalkyl, which are optionally substituted by one or more A, -C(O)-NR f R g , or
- R , R g , R and R J are each independently selected from hydrogen, Ci- 6 -alkyl, phenyl or 5- to 6-membered heteroaryl, optionally substituted with one or more A,
- R a and R are each independently hydrogen or Ci- 6 -alkyl
- R c is phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl
- R d is phenyl or 5- to 6-membered heteroaryl
- R e is Ci- 6 -alkyl, Ci- 6 -alkoxy, phenyl, or 5- to 6-membered heteroaryl
- R 8 or R 8 together with R 11 and the atoms to which they are bound form a 5- membered carbocycle, optionally anellated with benzo, wherein the benzo is optionally substituted with one, two or three substituents selected from halo, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6-alkoxy, Ci-6-haloalkoxy, nitro, hydroxy, or cyano, or a pharmaceutically acceptable salt thereof.
- R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, halo, Ci-6-alkyl, Ci-6-haloalkyl, Ci-6-alkoxy, or Ci-6-haloalkoxy.
- R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, halo, methyl, ethyl, trifluoromethyl, methoxy, ethoxy, or trifluoromethoxy.
- R 1 , R 2 , R 3 , and R 4 are each hydrogen.
- R 1 , R 2 , R 3 , and R 4 are independently hydrogen or halo.
- R 2 is fluoro
- R 1 , R 3 and R 4 are hydrogen
- R 1 , R 2 and R 4 are hydrogen and R 3 is chloro or bromo.
- R 1 , R 2 , R 3 , and R 4 are independently hydrogen or methyl.
- R 5 and R 5 are each independently hydrogen or methyl; preferably, R 5 and R 5 are each hydrogen.
- R 6 and R 6 are each independently hydrogen or methyl; preferably, R 6 and R 6 are each hydrogen.
- R 7 is hydrogen, Ci- 6 -alkyl, -C(O)O-Ci- 6 -alkyl, or -C(O)O- C 2 - 6 -alkenyl. In certain embodiments, R 7 is hydrogen, Ci- 6 -alkyl, or -C(O)O-C 2 - 6 -alkenyl. Preferably, R 7 is hydrogen or Ci-6-alkyl, and more preferably, R 7 is hydrogen.
- R 8 , R 8 , R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen, Ci- 4 -alkyl, Ci- 4 -hydroxyalkyl, Ci- 4 -cyanoalkyl, Ci- 4 -haloalkyl, C 1 - 4 - alkoxy, Ci- 4 -haloalkoxy, or hydroxy.
- R 8 , R 8 , R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen, Ci- 4 -alkyl, Ci- 4 -haloalkyl, Ci- 4 -alkoxy, Ci- 4 -haloalkoxy, or hydroxy.
- R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen, Ci- 4 -alkyl, Ci- 4 -hydroxyalkyl, Ci- 4 -cyanoalkyl, Ci- 4 -haloalkyl, C 1-4 - alkoxy, Ci- 4 -haloalkoxy, or hydroxy, and R 8 and R 8 are hydrogen.
- R 8 , R 8 , R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen, methyl, ethyl, trifluoromethyl, methoxy or hydroxy.
- R 8 , R 8 , R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen, methyl, ethyl, or trifluoromethyl.
- R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen, methyl, ethyl, or trifluoromethyl, and R 8 and R 8 are hydrogen.
- R 11 is as described above.
- R 11 is Ci-6-alkyl, optionally substituted by CN, OH or halogen, -(CR 1 R 11 U-R 111 , wherein R 1 and R 11 are independently from each other H,
- Ci- 4 -alkyl optionally substituted with OH, wherein m is from 0 to 4, wherein R 111 is phenyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, or 3- to 7-membered heterocycloalkyl, which are optionally substituted by one or more A,
- R lv is Ci-6-alkyl, optionally substituted with OH, or CN,
- R f , and R g are each independently selected from hydrogen, Ci- 6 -alkyl, phenyl or 5- to 6-membered heteroaryl, optionally substituted with one or more A,
- R a and R b are each independently hydrogen or Ci- 6 -alkyl
- R c is phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl
- R is phenyl or 5- to 6-membered heteroaryl
- R e is Ci- 6 -alkyl, Ci- 6 -alkoxy, phenyl, or 5- to 6-membered heteroaryl
- R 1 and R 11 are independently from each other H, OH, C 1-4 -alkyl, or Ci- 4 -hydroxyalkyl; or one R 1 and one R 11 together with the carbon atom to which they are bound form a 3 to 5-membered cycloalkyl.
- linkers -(CR 1 R 1 V are: -CH 2 -, -C(OH)H-, -C(OH)CH 3 -, -
- variable m in -(CR 1 IO 1n -R 111 is 0, 1, 2, 3 or 4.
- m is 0, 1 or 2. More preferably, m is 0 or 1.
- R 111 is phenyl, naphthyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, or 3- to 7-membered cycloalkyl
- m is selected from 0, 1, 2, 3 or 4.
- m is 0, 1, or 2; more preferred is 0 or 1.
- R 111 is 3- to 7-membered heterocycloalkyl and m is 0, the attachment point of the 3- to 7-membered heterocycloalkyl is preferably a carbon atom.
- the 3- to 7- membered heterocycloalkyl of R 111 is attached via a carbon atom, regardless of the nature of m.
- m is 1.
- R 111 is phenyl
- phenyl is optionally substituted with one ore more, preferably one or two, substituents as described herein.
- substituents comprise the substituents defined herein as "A”.
- the subsitituents are halo, hydroxy, Q-6-haloalkyl, Q-6-alkyl, Ci-6-alkoxy, Ci-6-haloalkoxy, cyano, Q-6-cyanoalkyl, -CH 2 OCH 3 , -S(O) 2 -Ci- 6 -alkyl, C 1-6 -hydroxyalkyl, -C(O)OC 1-6 -alkyl, -N(C 1-6 -alkyl) 2 , -NH(Ci- 6 -alkyl), NH 2 , -NHC(O)-C 1-6 -alkyl, -NH(CH 2 C(O)OCi- 6 -alkyl), -NHS(O) 2 Ci
- R 111 in -(CR 1 R 1 X-R 111 is 5 to 6-membered heteroaryl
- 5- to 6-membered heteroaryl is as defined above, namely pyrrolyl, pyrazolyl, imidazolyl, furanyl (synonymous to furyl), thiophenyl (synonymous to thienyl), oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl.
- Preferred 5 to 6-membered heteroaryl groups are pyrazolyl, imidazolyl, thiophenyl (synonymous to thienyl), oxazolyl, thiazolyl, pyridinyl, or pyrimidinyl, in particular l,3-oxazol-2-yl, 2-thienyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrazol-4-yl, l,3-thiazol-2-yl, pyrimidin-2-yl or imidazol-2-yl. All these residues are optionally substituted as described herein.
- These optional substitutents comprise the substituents defined herein as "A".
- the subsitituents are halo, Ci- 6 -haloalkyl, Ci- 6 -alkyl, Ci- 6 -alkoxy, Ci- 6 -haloalkoxy, cyano, Ci- 6 -cyanoalkyl, -CH 2 OCH 3 , -S(O) 2 -Ci- 6 -alkyl, Ci- 6 -hydroxyalkyl, -C(O)OC 1-6 -alkyl, -NHC(O)-C 1-6 -alkyl, -NHS(O) 2 Ci- 6 -alkyl, -C(O)N(Ci- 6 -alkyl) 2) -C(O)NH(C 1-6 -alkyl), -S(O) 2 N(Ci- 6 -alkyl) 2) or -S(O) 2 NH(Ci-6-alkyl) are preferred. Particular
- R m in -(CR 1 IO 1n -R 111 is 9- to 10-membered bicyclic heteroaryl
- 9- to 10- membered bicyclic heteroaryl is as defined above, namely indolyl, benzoimidazolyl, indazolyl, benzooxazolyl, lH-pyrrolo[2,3-c]pyridinyl, benzothienyl, benzofuranyl, purinyl, quinolinyl, isoquinolinyl, quinazolinyl, quinoxalinyl, cinnolinyl, phthalazinyl, or pteridinyl.
- Preferred 9- to 10-membered bicyclic heteroaryl groups are benzofuranyl, benzothienyl, indolyl, benzoimidazolyl, indazolyl, or benzooxazolyl. More preferred is benzofuranyl, in particular l-benzofuran-2-yl. All these residues are optionally substituted as described herein. These optional substitutents comprise the substituents defined herein as "A".
- the subsitituents are halo, Ci- 6 -haloalkyl, Ci- 6 -alkyl, Ci- 6 -alkoxy, Ci- 6 -haloalkoxy, cyano, Ci- 6 -cyanoalkyl, -CH 2 OCH 3 , -S(O) 2 -Ci- 6 -alkyl, Ci- 6 -hydroxyalkyl, -C(O)OCi- 6 -alkyl, -NHC(O)-C 1-6 -alkyl, -NHS(O) 2 C 1-6 -alkyl, -C(O)N(Ci- 6 -alkyl) 2 , -C(O)NH(Ci- 6 -alkyl), -S(O) 2 N(Ci- 6 -alkyl) 2 , or -S(O) 2 NH(C 1-6 -alkyl) are preferred.
- 3- to 7-membered heterocycloalkyl is as defined above, namely oxiranyl, thiiranyl, aziridinyl, oxetanyl, azetidinyl, tetrahydro-furanyl, tetrahydro-thiophenyl (synonymous with tetrahydro-thienyl), pyrrolidinyl, pyrazolidinyl, imidazolidinyl, oxazidinyl, isoxazidinyl, thiazolidinyl, isothiazolidinyl, piperidinyl, piperazidinyl, morpholinyl, or tetrahydropyranyl.
- R 111 is 3- to 7-membered heterocycloalkyl
- oxiranyl, oxetanyl, pyrrolidinyl, piperidinyl, piperazidinyl, morpholinyl, or tetrahydropyranyl are preferred. More preferred is pyrrolidin-2-yl. All these residues are optionally substituted as described herein. These optional substitutents comprise the substituents defined herein as "A".
- subsitituents O, hydroxy, halo, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6-alkoxy, C 1 ⁇ - haloalkoxy, cyano, Ci- 6 -cyanoalkyl, -CH 2 OCH 3 , -S(O) 2 -Ci- 6 -alkyl, Ci- 6 -hydroxyalkyl, -C(O)OCi- 6 -alkyl, -N(C 1-6 -alkyl) 2 , -S(O) 2 N(Ci- 6 -alkyl) 2 , -NHC(O)-C 1-6 -alkyl, -NHS(O) 2 Ci- 6 -alkyl, -C(O)N(Ci- 6 -alkyl) 2 , -C(O)NH(C 1-6 -alkyl), -S(O) 2 N(Ci- 6 -alkyl) 2 , -
- R lv is as described above. In certain embodiments, R lv is Ci-6-alkoxy, hydroxy, phenyl, -Obenzyl, 5- to 6-membered monocyclic heteroaryl, or 3- to 7-membered heterocycloalkyl, which are optionally substituted by one or more A as described herein.
- R lv is Ci-6-alkoxy, hydroxy, -Obenzyl, or 3- to 7-membered heterocycloalkyl, which are optionally substituted by one or more A as described herein.
- R lv is 3- to 7-membered heterocycloalkyl which is optionally substituted as described herein.
- R lv is Ci-6-alkoxy, hydroxy, phenyl, -Obenzyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, m is preferably 0, 1 or 2.
- R lv is 3- to 7-membered heterocycloalkyl
- m is preferably 0, 1 or 2, more preferably 0.
- R lv is 5 to 6-membered heteroaryl
- 5- to 6-membered heteroaryl is as defined above, namely pyrrolyl, pyrazolyl, imidazolyl, furanyl (synonymous to furyl), thiophenyl (synonymous to thienyl), oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl. Phenyl and 5- to 6-membered heteroaryl are optionally substituted as described herein.
- R lv is phenyl, naphthyl, benzyl, -Obenzyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl
- preferred optional subsitituents are halo, hydroxy, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6-alkoxy, Ci-6-haloalkoxy, cyano, Ci-6-cyanoalkyl, -CH 2 OCH 3 , -S(O) 2 -Ci- 6 -alkyl, Ci- 6 -hydroxyalkyl, -C(O)OCi- 6 -alkyl, -N(C 1-6 -alkyl) 2 , -NH(Ci- 6 -alkyl), NH 2 , -NHC(O)-C 1-6 -alkyl, -NH(CH 2 C(O)OCi- 6 -alkyl), -NHS(O) 2 Ci- 6 -
- 3- to 7-membered heterocycloalkyl is as defined above, namely oxiranyl, thiiranyl, aziridinyl, oxetanyl, azetidinyl, tetrahydro-furanyl, tetrahydro-thiophenyl (synonymous with tetrahydro- thienyl), pyrrolidinyl, pyrazolidinyl, imidazolidinyl, oxazidinyl, isoxazidinyl, thiazolidinyl, isothiazolidinyl, piperidinyl, piperazidinyl, morpholinyl, or tetrahydropyranyl.
- Preferred 3- to 7-membered heterocycloalkyl groups are those comprising at least one nitrogen atom, which is attached to the carbonyl group of R 111 .
- Particularly preferred are O, hydroxy, Ci- 6 -alkyl, -S(O) 2 -Ci- 6 -alkyl, Ci- 6 -hydroxyalkyl, -N(Ci-6-alkyl) 2 , -S(O) 2 N(Ci- 6 -alkyl) 2 , or -C(O)N(C 1-6 -alkyl) 2 , or those subsitutents as specifically indicated in the examples.
- R m is -C(O)-NR f R g , then m is preferably 0, 1 or 2, more preferably 0 or 1.
- R 111 is -NR f R g
- m is preferably 1, 2 or 3, more preferably 1 or 2.
- R f , R g , R h and/or R are 5- to 6-membered heteroaryl
- 5- to 6-membered heteroaryl is as defined above, namely pyrrolyl, pyrazolyl, imidazolyl, furanyl (synonymous to furyl), thiophenyl (synonymous to thienyl), oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl.
- Preferred 5- to 6-membered heteroaryl groups are isoxazolyl, pyridinyl, pyrimidinyl, or pyrazinyl; in particular pyridine-2-yl, pyrazin-2-yl, isoxazol-3-yl or pyrimidin-2-yl. All these residues are optionally substituted as described herein. In particular, these optional subtituents comprise the subtituents defined with "A".
- A defines the optional substituents of cyclic groups of R 111 , namely phenyl, naphthyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, 3- to 7- membered heterocycloalkyl, or 3- to 7-membered cycloalkyl; of cyclic groups of R 1V , namely phenyl, naphthyl, benzyl, -Obenzyl, 5- to 6-membered monocyclic or 9- to 10- membered bicyclic heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl; and of R f , R g , R h and R ⁇ namely phenyl or 5- to 6-membered heteroaryl.
- R c is phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl, optionally substituted with one, two, or three halo, Ci-6-haloalkyl, Ci-6-alkyl, or Ci-6-alkoxy, R is phenyl or 5- to 6-membered heteroaryl, optionally substituted with one, two, or three halo, Ci-6-haloalkyl, Ci-6-alkyl, or Ci-6-alkoxy,
- R e is d- 6 -alkyl, Ci-6-alkoxy, phenyl, or 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl, optionally substituted with one, two, or three halo, Ci-6-haloalkyl,
- Ci-6-alkyl or Ci-6-alkoxy.
- R c is phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl, optionally substituted with one, two, or three halo, Ci-6-haloalkyl, Ci-6-alkyl, or Ci-6-alkoxy, R is phenyl or 5- to 6-membered heteroaryl, optionally substituted with one, two, or three halo, Ci-6-haloalkyl, Ci-6-alkyl, or Ci-6-alkoxy, R e is Ci- 6 -alkyl,
- 3- to 7-membered cycloalkyl optionally substituted with one, two, or three halo, Ci-6-haloalkyl, Ci- 6 -alkyl, or Ci- 6 -alkoxy.
- Preferred A for aromatic rings are halo, nitro, hydroxy, cyano, Ci-6-alkyl, C 1- O- haloalkyl, Ci-6-hydroxyalkyl, Ci-6-cyanoalkyl, Ci-6-alkoxy, Ci-6-haloalkoxy,
- R is phenyl or 5- to 6-membered heteroaryl
- R e is Ci-6-alkyl, Ci-6-alkoxy, phenyl, or 5- to 6-membered heteroaryl, 3- to 7- membered heterocycloalkyl, or 3- to 7-membered cycloalkyl, wherein phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl of R c , R or R e are optionally substituted with one, two, or three halo, Ci-6-haloalkyl, Ci-6-alkyl, or Ci-6-alkoxy.
- one of R or R together with R and the atoms to which they are bound form a 5-membered carbocycle, optionally anellated with benzo, wherein the benzo is optionally substituted with one, two or three substituents selected from halo, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6-alkoxy, Ci-6-haloalkoxy, nitro, hydroxy, or cyano.
- R 8 or R 8 together with R 11 form fluorene, optionally substituted with one, two or three substituents selected from halo, Ci-6-haloalkyl, C 1 ⁇ - alkyl, Ci-6-alkoxy, Ci-6-haloalkoxy, nitro, hydroxy, or cyano.
- R 11 is C 1-6 -alkyl, C 1-6 -hydroxyalkyl, Ci- 6 -cyanoalkyl, or -(CR'R u ) m -R m , wherein R 1 , R 11 and R 111 are as defined above.
- the compounds of the invention are those compounds of formula (I-a), wherein X is CH 2 , and Y is O, and R 1 to R 11 are as defined above.
- the compounds of the invention are those compounds of formula (I-c), X is O, and Y is CH 2 , and R 1 to R 11 are as defined above.
- the compounds of the invention are those compounds of formula (I-e), X is NR 7 , and Y is CH 2 , and R 1 to R 11 are as defined above.
- the compounds of the invention are those compounds of formula (I-g), X-Y is -CH 2 CH 2 -, and R 1 to R 11 are as defined above.
- Preferred embodiments of the present invention are those of compounds I-a, I-b. I-c. I-e. I-f or I-g, particularly preferred are those of I-a or I-b.
- X and Y are selected from the combinations of:
- X is CH 2 , and Y is O,
- X is O, and Y is CH 2 ,
- X is NR 7
- X is NR 7
- Y is CH 2
- X-Y is -CH 2 CH 2 -, or
- R 1 , R 2 , R 3 , and R 4 are each independently hydrogen, halo, methyl, ethyl, trifiuoromethyl, methoxy, ethoxy, or trifiuoromethoxy; R 5 and R 5 are each hydrogen;
- R 6 and R 6 are each independently hydrogen or methyl;
- R 7 is hydrogen, Ci- 6 -alkyl, or -C(O)O-C 2 - 6 -alkenyl;
- R 8 , R 8 , R 9 , R 9 , and R 10 are each independently selected from hydrogen, halogen,
- Ci- 4 -alkyl optionally substituted by CN or OH, Ci- 4 -haloalkyl, Ci- 4 -alkoxy, Ci- 4 -haloalkoxy, hydroxy;
- R 11 is Ci-6-alkyl, optionally substituted by CN, OH or halogen, -(CR 1 R 1 X-R 111 , wherein R 1 and R 11 are independently from each other H, OH, Ci- 4 -alkyl, optionally substituted with OH, wherein m is from 0 to 4, wherein R 111 is phenyl, 5- to 6-membered monocyclic or 9- to 10-membered bicyclic heteroaryl, or 3- to 7-membered heterocycloalkyl, which are optionally substituted by one or more A,
- Ci- 6 -alkyl optionally substituted with OH, or CN, Ci- 6 -alkoxy, hydroxy, phenyl, -Obenzyl, 5- to 6-membered monocyclic heteroaryl, or 3- to 7-membered heterocycloalkyl, which are optionally substituted by one or more A, -C(O)-NR f R g , wherein R , and R g are each independently selected from hydrogen, Ci-e-alkyl, phenyl or 5- to 6-membered heteroaryl, optionally substituted with one or more A,
- R a and R are each independently hydrogen or Ci- 6 -alkyl
- R c is phenyl, 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl
- R d is phenyl or 5- to 6-membered heteroaryl
- R e is Ci- 6 -alkyl, Ci- 6 -alkoxy, phenyl, or 5- to 6-membered heteroaryl, 3- to 7-membered heterocycloalkyl, or 3- to 7-membered cycloalkyl, wherein phenyl, 5- to 6-membered heteroaryl, 3- to 7- membered heterocycloalkyl, or 3- to 7-membered cycloalkyl of R c , R d or R e are optionally substituted with one, two, or three halo, Ci- 6 -haloalkyl, Ci- 6 -alkyl, or Ci-6-alkoxy, or one of R 8 or R 8 together with R 11 and the atoms to which they are bound form a 5- membered carbocycle, optionally anellated with benzo, wherein the benzo is optionally substituted with one, two or three substituents selected from halo, Ci-6-haloalkyl, Ci-6-alkyl, Ci-6
- Preferred compounds of the invention are those explicitly shown in the examples.
- the invention also encompasses the compounds of formula (I), (I-a), (I-b), (I-c), (I- d), (I-e), (I-f), (I-g) or (I-h) for a use in the prevention or treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders.
- the invention also encompasses a pharmaceutical composition
- a pharmaceutical composition comprising a compound of formula (I), (I-a), (I-b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h), which pharmaceutical composition is useful against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders.
- the pharmaceutical composition may further comprise at least one pharmaceutically acceptable excipient.
- the invention further encompasses the use of a compound of formula (I), (I-a), (I- b), (I-c), (I-d), (I-e), (I-f), (I-g) or (I-h), for the preparation of a medicament which is useful against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxiety and depressive disorders.
- the compounds of formula (I) of the invention can be manufactured according to a process comprising the step of reacting a compound of formula (II):
- the compounds of formula (I) of the invention can be manufactured according to a process comprising the step of reacting a compound of formula (V)
- LG is a leaving group, preferably halogen, -OSO 2 Me, -OSO 2 C 6 H 4 CH 3 ,
- the compounds of formula (I) of the invention can be manufactured according to a process comprising the step of reacting a compound of formula (1-4)
- HATU O-(7-azabenzotriazol-l-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate
- DIPEA N,N-diisopropylethylamine
- LDA lithiumdiisopropylamide
- LG leaving group, e.g. halogen, OSC ⁇ Me, OSO2C6H4CH3 MW: microwave
- R 7 is hydrogen or C,_ 6 -alkyl 1-2
- R 7 is hydrogen or C 1 6 -alkyl
- the compounds of the present invention exhibit Via activity, which may be detected as described below:
- Via activity Material & Method The human Via receptor was cloned by RT-PCR from total human liver RNA. The coding sequence was subcloned in an expression vector after sequencing to confirm the identity of the amplified sequence. To demonstrate the affinity of the compounds from the present invention to the human Via receptor binding studies were performed. Cell membranes were prepared from HEK293 cells transiently transfected with the expression vector and grown in 20 liter fermenters with the following protocol.
- the pellet was resuspended in 12.5 ml Lysis buffer+12.5ml Sucrose 20% and homogenized using a Polytron for 1-2 min.
- the protein concentration was determined by the Bradford method and aliquots are stored at -80 0 C until use.
- 60mg Yttrium silicate SPA beads (Amersham) were mixed with an aliquot of membrane in binding buffer (50 mM Tris, 12OmM NaCl, 5 mM KCl, 2 mM CaCl2, 10 mM MgCl2) for 15 minutes with mixing.
- the compounds of formula (I), and (I-a) to (I-h) as well as their pharmaceutically usable acid addition salts can be used as medicaments, e.g. in the form of pharmaceutical preparations.
- the pharmaceutical preparations can be administered orally, e.g. in the form of tablets, coated tablets, dragees, hard and soft gelatine capsules, solutions, emulsions or suspensions.
- the administration can, however, also be effected rectally, e.g. in the form of suppositories, or parenterally, e.g. in the form of injection solutions.
- the compounds of formula (I), (I-a) to (I-h) and their pharmaceutically usable acid addition salts can be processed with pharmaceutically inert, inorganic or organic excipients for the production of tablets, coated tablets, dragees and hard gelatine capsules. Lactose, corn starch or derivatives thereof, talc, stearic acid or its salts etc can be used as such excipients e.g. for tablets, dragees and hard gelatine capsules.
- Suitable excipients for soft gelatine capsules are e.g. vegetable oils, waxes, fats, semisolid and liquid polyols etc.
- Suitable excipients for the manufacture of solutions and syrups are e.g. water, polyols, saccharose, invert sugar, glucose etc.
- Suitable excipients for injection solutions are e.g. water, alcohols, polyols, glycerol, vegetable oils etc.
- Suitable excipients for suppositories are e.g. natural or hardened oils, waxes, fats, semi-liquid or liquid polyols etc.
- the pharmaceutical preparations can contain preservatives, solubilizers, stabilizers, wetting agents, emulsifiers, sweeteners, colorants, flavorants, salts for varying the osmotic pressure, buffers, masking agents or antioxidants. They can also contain still other therapeutically valuable substances.
- the dosage can vary within wide limits and will, of course, be fitted to the individual requirements in each particular case.
- a daily dosage of about 10 to 1000 mg per person of a compound of general formula (I) should be appropriate, although the above upper limit can also be exceeded when necessary.
- the active substance, lactose and corn starch are firstly mixed in a mixer and then in a comminuting machine.
- the mixture is returned to the mixer, the talc is added thereto and mixed thoroughly.
- the mixture is filled by machine into hard gelatine capsules.
- the suppository mass is melted in a glass or steel vessel, mixed thoroughly and cooled to 45°C. Thereupon, the finely powdered active substance is added thereto and stirred until it has dispersed completely.
- the mixture is poured into suppository moulds of suitable size, left to cool; the suppositories are then removed from the moulds and packed individually in wax paper or metal foil.
- Step 1 l-Benzyl-4-(2-hvdroxymethyl-phenyl)-piperidin-4-ol
- 2-Bromobenzyl alcohol 100 g, 0.535 mol was dissolved in THF (600 mL), and a 2.8 M solution of ethylmagnesium chloride (191 mL, 0.535 mol) was added slowly. During the addition the temperature increased, and the addition rate was adjusted to ensure gentle reflux. When the addition of EtMgCl was finished, magnesium turnings (13 g, 0.535 mol) were added in portions. Sufficient heat was applied to keep the reaction refluxing. When the addition was complete, the reaction mixture was refluxed gently for at least 2 h.
- the title compound was prepared from N-(2-benzoyl-phenyl)-4-methyl- benzenesulfonamide by oxime formation followed oxime reduction by previously reported methods. 12
- the title compound was prepared from intermediate 19 by hydrolysis of the ester group.
- Step 1 tert-Butyl ⁇ ( IR)-I -methyl-2-oxo-2- ( 1 ⁇ ,3H-spiro [2-benzofuran- 1 ,4'-piperidin] - 1 '- yl) ethyll carbamate
- Step 1 tert-Butyl [1,1 -dimethyl-2-oxo-2- ( 1 ⁇ ,3H-spiro [2-benzofuran- 1 ,4'-piperidin] - 1 '- yl) ethyll carbamate
- Step 2 Methyl (2R)- ⁇ [(allyloxy)carbonyl1 [2-oxo-2-(l ⁇ ,3H-spiro[2-benzofuran-l,4'- piperidin1-r-yl)ethyl]aminoKphenyl)acetate
- Step 3 (2R)- ⁇ [(Allyloxy)carbonyll [2-oxo-2-(l ⁇ ,3-Fi-spiro[2-benzofuran-l,4'-piperidin]- r-yl)ethyllamino ⁇ (phenyl)acetic acid
- Step 3 (2R)- ⁇ [(Allyloxy)carbonyll [2-oxo-2-(l ⁇ ,3H-spiro[2-benzofuran-l,4'-piperidin1- r-yl)ethyllamino ⁇ (4-chlorophenyl)acetic acid
- Step 2 (_R)-2-[2-(3-Chloro-phenyl)-2-oxo-ethyll-pyrrolidine-l-carboxylic acid ferf-butyl ester
- Example 16 4-Chloro- ⁇ r-ethvl- ⁇ r-methvl-2-[ ⁇ [2-oxo-2-(l ⁇ ,3H-spiro[2-benzofuran-l,4'- piperidin] - 1 '-yl)ethyl] amino ⁇ (phenyl)methyl] aniline
- Example 38 r ⁇ -Ethyl N- ⁇ 4-chloro-2-[ ⁇ [2-oxo-2-(l'H,3H-spiro[2-benzofuran-l,4'- piperidin] - 1 '-yl)ethyl] amino ⁇ (phenyl)methyl] phenyljglycinate
- Example 50 (1 ⁇ 5,2 ⁇ 5)-l-(4-Chlorophenyl)-l- ⁇ [2-oxo-2-(l'H,3H-spiro[2-benzofuran- l,4'-piperidin]-r-yl)ethyl]amino ⁇ -2-pyridin-3-yl-propan-2-ol
- Example 51 l-(4-Chlorophenyl)-l- ⁇ [2-oxo-2-(l ⁇ ,3H-spiro[2-benzofuran-l,4'- piperidin]-r-yl)ethyl]amino ⁇ -2-pyridin-3-yl-propan-2-ol
- Example 52 l-(4-Chlorophenyl)-l- ⁇ [2-oxo-2-(l ⁇ ,3H-spiro[2-benzofuran-l,4'- piperidin]-r-yl)ethyl]amino ⁇ -2-pyridin-4-ylpropan-2-ol
- Example 65 (RS)- ⁇ T-[(3-Chlorophenyl) ⁇ 3-[(4-methylpiperazin-l- yl)methyl]phenyl ⁇ methyl]-2-oxo-2-(l ⁇ ,3ff-spiro[2-benzofuran-l,4'-piperidin]-r- yl)ethanamine
- Example 70 N-(Diphenylmethyl)-2-methyl-l-oxo-l-(l ⁇ ,3ff-spiro[2-benzofuran-l,4'- piperidin] - 1 '-yl)propan-2-amine
- Example 74 ⁇ (2R)-l-[(2R)-2- ⁇ [2-Oxo-2-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin1-l'- yl)ethyl]amino ⁇ -2-phenylacetyl]pyrrolidin-2-yl ⁇ methanol
- Example 75 l-[(2R)-2- ⁇ [2-Oxo-2-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin]-l'- yl)ethyl]amino ⁇ -2-phenylacetyl]pyrrolidin-3-ol
- Example 78 l-[(2R)-2- ⁇ [2-Oxo-2-(l'H,3H-spiro[2-benzofuran-l,4'-piperidin1-l'- yl)ethyl]amino ⁇ -2-phenylacetyl]piperidin-4-ol
- Example 80 2- ⁇ 4- [ (2R)-2- ⁇ [2-Oxo-2- ( 1 ⁇ ,3H-spiro [2-benzofuran- l,4'-piperidin] - 1 '- yl)ethyl]amino ⁇ -2-phenylacetyl]piperazin-l-yl ⁇ ethanol
- Example 81 ( IR) -2- [4- (Methylsulfonyl)piperazin- 1 - yll -2-oxo- ⁇ T- [2-oxo-2- ( 1 ⁇ ,3H- spiro [2-benzofuran- l,4'-piperidin] - l'-yl)ethyl] - 1-phenylethanamine
- Example 87 iV,iV-Dimethvl-4-[(2R)-2- ⁇ [2-oxo-2-(l'H,3H-spiro[2-benzofuran-l,4'- piperidin]-r-yl)ethyl]amino ⁇ -2-phenylacetyl]piperazine-l-sulfonamide
- Example 90 terf-Butyl (25)-2-[(25)-2-(3-chlorophenyl)-2- ⁇ [2-oxo-2-(l'H,3H-spiro[2- benzofuran- l,4'-piperidin] - l'-yl) ethyl] amino ⁇ ethyl]pyrrolidine- 1-carboxylate
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MX2009007411A MX2009007411A (en) | 2007-01-12 | 2008-01-03 | Spiropiperidine glycinamide derivatives. |
BRPI0806538-1A2A BRPI0806538A2 (en) | 2007-01-12 | 2008-01-03 | SPYROPIPERIDINE GLYCINAMIDE DERIVATIVES |
EP08701212A EP2104677B1 (en) | 2007-01-12 | 2008-01-03 | Spiropiperidine glycinamide derivatives |
AT08701212T ATE536356T1 (en) | 2007-01-12 | 2008-01-03 | SPIROPIPERIDINE GLYCINAMIDE DERIVATIVES |
KR1020097016714A KR101129791B1 (en) | 2007-01-12 | 2008-01-03 | Spiropiperidine glycinamide derivatives |
CA002674958A CA2674958A1 (en) | 2007-01-12 | 2008-01-03 | Spiropiperidine glycinamide derivatives |
JP2009545158A JP2010515700A (en) | 2007-01-12 | 2008-01-03 | Spiropiperidine glycinamide derivatives |
AU2008204491A AU2008204491B2 (en) | 2007-01-12 | 2008-01-03 | Spiropiperidine glycinamide derivatives |
ES08701212T ES2376378T3 (en) | 2007-01-12 | 2008-01-03 | DERIVATIVES OF ESPIROPIPERIDINA-GLICINAMIDA. |
CN200880002180XA CN101583615B (en) | 2007-01-12 | 2008-01-03 | Spiropiperidine glycinamide derivatives |
IL199583A IL199583A0 (en) | 2007-01-12 | 2009-06-25 | Spiropiperidine glycinamide derivatives |
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US (3) | US20080194610A1 (en) |
EP (1) | EP2104677B1 (en) |
JP (1) | JP2010515700A (en) |
KR (1) | KR101129791B1 (en) |
CN (1) | CN101583615B (en) |
AR (1) | AR064831A1 (en) |
AT (1) | ATE536356T1 (en) |
AU (1) | AU2008204491B2 (en) |
BR (1) | BRPI0806538A2 (en) |
CA (1) | CA2674958A1 (en) |
CL (1) | CL2008000059A1 (en) |
ES (1) | ES2376378T3 (en) |
IL (1) | IL199583A0 (en) |
MX (1) | MX2009007411A (en) |
PE (1) | PE20081851A1 (en) |
TW (1) | TW200836728A (en) |
WO (1) | WO2008084005A1 (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010054961A1 (en) | 2008-11-13 | 2010-05-20 | F. Hoffmann-La Roche Ag | Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes |
US8227458B2 (en) | 2008-11-28 | 2012-07-24 | Hoffmann-La Roche Inc. | Arylcyclohexylethers of dihydrotetraazabenzoazulenes |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
US8642590B2 (en) | 2008-11-18 | 2014-02-04 | Hoffmann-La Roche Inc. | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
WO2015124541A1 (en) * | 2014-02-20 | 2015-08-27 | F. Hoffmann-La Roche Ag | Spiro-oxazolones |
WO2016075181A1 (en) * | 2014-11-14 | 2016-05-19 | F. Hoffmann-La Roche Ag | Spiro-thiazolones |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2670674A1 (en) * | 2006-12-07 | 2008-06-12 | F. Hoffmann-La Roche Ag | Spiro-piperidine derivatives as via receptor antagonists |
US20080153863A1 (en) * | 2006-12-22 | 2008-06-26 | Caterina Bissantz | Spiropiperidine derivatives |
ATE536356T1 (en) * | 2007-01-12 | 2011-12-15 | Hoffmann La Roche | SPIROPIPERIDINE GLYCINAMIDE DERIVATIVES |
WO2015091411A1 (en) | 2013-12-19 | 2015-06-25 | F. Hoffmann-La Roche Ag | Spiro-oxazolones |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005046682A1 (en) * | 2003-11-04 | 2005-05-26 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
WO2007006688A1 (en) * | 2005-07-14 | 2007-01-18 | F. Hoffmann-La Roche Ag | Indol-3-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3370091A (en) * | 1964-06-15 | 1968-02-20 | Hoffmann La Roche | 2 aminobenzhydrylhalides |
US3531467A (en) * | 1966-12-23 | 1970-09-29 | Hoffmann La Roche | Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives |
DK78692D0 (en) | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | DIMER PIPERIDINE AND PIPERAZINE DERIVATIVES |
IT1271026B (en) | 1994-10-21 | 1997-05-26 | Isagro Ricerca Srl | DERIVATIVES OF B-AMINOPROPIONIC ACID WITH FUNGICIDE ACTIVITY |
GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
US20040152741A1 (en) | 2002-09-09 | 2004-08-05 | Nps Allelix Corporation | Arylglycine derivatives and their use as glycine transport inhibitors |
AU2003263155A1 (en) | 2002-09-20 | 2004-04-08 | H. Lundbeck A/S | Method for manufacture of dihydroisobenzofuran derivatives |
WO2004069809A1 (en) | 2003-02-03 | 2004-08-19 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
US7244852B2 (en) * | 2003-02-27 | 2007-07-17 | Abbott Laboratories | Process for preparing 2-methylpyrrolidine and specific enantiomers thereof |
JP2009507800A (en) * | 2005-09-09 | 2009-02-26 | ユーロ−セルティーク エス.エイ. | Fused and spirocyclic compounds and uses thereof |
ATE536356T1 (en) * | 2007-01-12 | 2011-12-15 | Hoffmann La Roche | SPIROPIPERIDINE GLYCINAMIDE DERIVATIVES |
-
2008
- 2008-01-03 AT AT08701212T patent/ATE536356T1/en active
- 2008-01-03 JP JP2009545158A patent/JP2010515700A/en active Pending
- 2008-01-03 BR BRPI0806538-1A2A patent/BRPI0806538A2/en not_active IP Right Cessation
- 2008-01-03 EP EP08701212A patent/EP2104677B1/en not_active Not-in-force
- 2008-01-03 MX MX2009007411A patent/MX2009007411A/en not_active Application Discontinuation
- 2008-01-03 CN CN200880002180XA patent/CN101583615B/en not_active Expired - Fee Related
- 2008-01-03 AU AU2008204491A patent/AU2008204491B2/en not_active Expired - Fee Related
- 2008-01-03 CA CA002674958A patent/CA2674958A1/en not_active Abandoned
- 2008-01-03 WO PCT/EP2008/050028 patent/WO2008084005A1/en active Application Filing
- 2008-01-03 KR KR1020097016714A patent/KR101129791B1/en not_active IP Right Cessation
- 2008-01-03 ES ES08701212T patent/ES2376378T3/en active Active
- 2008-01-07 US US11/969,983 patent/US20080194610A1/en not_active Abandoned
- 2008-01-07 US US11/969,975 patent/US7498339B2/en not_active Expired - Fee Related
- 2008-01-07 US US11/969,993 patent/US20080171760A1/en not_active Abandoned
- 2008-01-09 PE PE2008000099A patent/PE20081851A1/en not_active Application Discontinuation
- 2008-01-09 TW TW097100900A patent/TW200836728A/en unknown
- 2008-01-10 CL CL200800059A patent/CL2008000059A1/en unknown
- 2008-01-10 AR ARP080100089A patent/AR064831A1/en unknown
-
2009
- 2009-06-25 IL IL199583A patent/IL199583A0/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005046682A1 (en) * | 2003-11-04 | 2005-05-26 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
WO2007006688A1 (en) * | 2005-07-14 | 2007-01-18 | F. Hoffmann-La Roche Ag | Indol-3-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists |
Non-Patent Citations (1)
Title |
---|
SERRADEIL-LE GAL C ET AL: "NONPEPTIDE VASOPRESSIN RECEPTOR ANTAGONISTS: DEVELOPMENT OF SELECTIVE AND ORALLY ACTIVE V1A, V2 AND V1B RECEPTOR LIGANDS", PROGRESS IN BRAIN RESEARCH, ELSEVIER AMSTERDAM, NL, vol. 139, 2002, pages 197 - 210, XP001205440, ISSN: 0079-6123 * |
Cited By (19)
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AU2009315754B2 (en) * | 2008-11-13 | 2013-08-15 | F. Hoffmann-La Roche Ag | Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes |
US8664216B2 (en) | 2008-11-13 | 2014-03-04 | Hoffmann-La Roche Inc. | Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes |
KR101348499B1 (en) | 2008-11-13 | 2014-01-06 | 에프. 호프만-라 로슈 아게 | Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes |
WO2010054961A1 (en) | 2008-11-13 | 2010-05-20 | F. Hoffmann-La Roche Ag | Spiro-5,6-dihydro-4h-2,3,5,10b-tetraaza-benzo[e]azulenes |
CN102216305B (en) * | 2008-11-13 | 2013-12-18 | 弗·哈夫曼-拉罗切有限公司 | Spiro-5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo[e]azulenes |
US8642590B2 (en) | 2008-11-18 | 2014-02-04 | Hoffmann-La Roche Inc. | Alkylcyclohexylethers of dihydrotetraazabenzoazulenes |
US8461152B2 (en) | 2008-11-28 | 2013-06-11 | Hoffmann-La Roche Inc. | Arylcyclohexylethers of dihydrotetraazabenzoazulenes |
US8227458B2 (en) | 2008-11-28 | 2012-07-24 | Hoffmann-La Roche Inc. | Arylcyclohexylethers of dihydrotetraazabenzoazulenes |
US8420633B2 (en) | 2010-03-31 | 2013-04-16 | Hoffmann-La Roche Inc. | Aryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8461151B2 (en) | 2010-04-13 | 2013-06-11 | Hoffmann-La Roche Inc. | Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes |
US8492376B2 (en) | 2010-04-21 | 2013-07-23 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8481528B2 (en) | 2010-04-26 | 2013-07-09 | Hoffmann-La Roche Inc. | Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes |
US8513238B2 (en) | 2010-05-10 | 2013-08-20 | Hoffmann-La Roche Inc. | Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes |
WO2015124541A1 (en) * | 2014-02-20 | 2015-08-27 | F. Hoffmann-La Roche Ag | Spiro-oxazolones |
CN105793266A (en) * | 2014-02-20 | 2016-07-20 | 豪夫迈·罗氏有限公司 | Spiro-oxazolone |
JP2017507144A (en) * | 2014-02-20 | 2017-03-16 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | Spirooxazolone |
US9828385B2 (en) | 2014-02-20 | 2017-11-28 | Hoffmann-La Roche Inc. | Spiro-oxazolones |
WO2016075181A1 (en) * | 2014-11-14 | 2016-05-19 | F. Hoffmann-La Roche Ag | Spiro-thiazolones |
US10092551B2 (en) | 2014-11-14 | 2018-10-09 | Hoffmann-Laroche Inc. | Spiro-thiazolones |
Also Published As
Publication number | Publication date |
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CN101583615A (en) | 2009-11-18 |
US20080171759A1 (en) | 2008-07-17 |
BRPI0806538A2 (en) | 2014-04-22 |
IL199583A0 (en) | 2010-03-28 |
KR20090097217A (en) | 2009-09-15 |
AR064831A1 (en) | 2009-04-29 |
CL2008000059A1 (en) | 2008-07-18 |
TW200836728A (en) | 2008-09-16 |
ES2376378T3 (en) | 2012-03-13 |
KR101129791B1 (en) | 2012-03-23 |
US20080171760A1 (en) | 2008-07-17 |
EP2104677B1 (en) | 2011-12-07 |
CA2674958A1 (en) | 2008-07-17 |
AU2008204491A1 (en) | 2008-07-17 |
US7498339B2 (en) | 2009-03-03 |
US20080194610A1 (en) | 2008-08-14 |
CN101583615B (en) | 2012-07-04 |
ATE536356T1 (en) | 2011-12-15 |
AU2008204491B2 (en) | 2012-05-03 |
MX2009007411A (en) | 2009-07-17 |
PE20081851A1 (en) | 2009-01-09 |
JP2010515700A (en) | 2010-05-13 |
EP2104677A1 (en) | 2009-09-30 |
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