WO2008081568A1 - 新規マクロライド化合物 - Google Patents

新規マクロライド化合物 Download PDF

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Publication number
WO2008081568A1
WO2008081568A1 PCT/JP2007/001425 JP2007001425W WO2008081568A1 WO 2008081568 A1 WO2008081568 A1 WO 2008081568A1 JP 2007001425 W JP2007001425 W JP 2007001425W WO 2008081568 A1 WO2008081568 A1 WO 2008081568A1
Authority
WO
WIPO (PCT)
Prior art keywords
macrolide compound
novel
novel macrolide
cancer agent
dinoflagellate
Prior art date
Application number
PCT/JP2007/001425
Other languages
English (en)
French (fr)
Inventor
Masashi Tsuda
Keiko Oguchi
Rie Iwamoto
Yumiko Okamoto
Original Assignee
National University Corporation Hokkaido University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Hokkaido University filed Critical National University Corporation Hokkaido University
Priority to EP07849855A priority Critical patent/EP2119792A4/en
Priority to JP2008552019A priority patent/JPWO2008081568A1/ja
Priority to US12/448,633 priority patent/US8071793B2/en
Publication of WO2008081568A1 publication Critical patent/WO2008081568A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D315/00—Heterocyclic compounds containing rings having one oxygen atom as the only ring hetero atom according to more than one of groups C07D303/00 - C07D313/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

　新規な渦鞭毛藻ならびに新規な抗ガン剤となり得るマクロライド化合物を提供することを目的とする。本発明は、渦鞭毛藻アンフィジニウム（Ａｍｐｈｉｄｉｎｉｕｍ ｓｐ．）ＨＹＡ００２株又はＨＹＡ０２４株で表される渦鞭毛藻が産生するマクロライド化合物に関する。本発明のマクロライド化合物はヒトの腫瘍細胞に対して優れた増殖抑制効果を有しており、新規な抗ガン剤として利用可能である。
PCT/JP2007/001425 2006-12-27 2007-12-19 新規マクロライド化合物 WO2008081568A1 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP07849855A EP2119792A4 (en) 2006-12-27 2007-12-19 INNOVATIVE MACROLIDE COMPOUND
JP2008552019A JPWO2008081568A1 (ja) 2006-12-27 2007-12-19 新規マクロライド化合物
US12/448,633 US8071793B2 (en) 2006-12-27 2007-12-19 Macrolide compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006351043 2006-12-27
JP2006-351043 2006-12-27

Publications (1)

Publication Number Publication Date
WO2008081568A1 true WO2008081568A1 (ja) 2008-07-10

Family

ID=39588258

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/001425 WO2008081568A1 (ja) 2006-12-27 2007-12-19 新規マクロライド化合物

Country Status (4)

Country Link
US (1) US8071793B2 (ja)
EP (2) EP2357249A1 (ja)
JP (1) JPWO2008081568A1 (ja)
WO (1) WO2008081568A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020147509A (ja) * 2019-03-12 2020-09-17 学校法人大阪医科薬科大学 抗がん剤

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
J.KOBAYASHI, TETERAHEDRON LETT., vol. 27, 1986, pages 5755
See also references of EP2119792A4 *
TSUDA M. ET AL.: "Iriomoteolides-1b and -1c, 20-membered macrolides from a marine dinoflagellate AMphidinium species", JOURNAL OF NATURAL PRODUCTS, vol. 70, no. 10, 2007, pages 1661 - 1663, XP008109992 *
TSUDA M. ET AL: "Amphidinolide U, novel 20-membered macrolide from marine dinoflagellate Amphidinium sp", TETRAHEDRON, vol. 55, no. 51, 1999, pages 14565 - 14570, XP004185326 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020147509A (ja) * 2019-03-12 2020-09-17 学校法人大阪医科薬科大学 抗がん剤
JP7334927B2 (ja) 2019-03-12 2023-08-29 学校法人大阪医科薬科大学 抗がん剤

Also Published As

Publication number Publication date
EP2119792A1 (en) 2009-11-18
US20100121079A1 (en) 2010-05-13
EP2357249A1 (en) 2011-08-17
EP2119792A4 (en) 2010-06-30
JPWO2008081568A1 (ja) 2010-04-30
US8071793B2 (en) 2011-12-06

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