WO2008075150A1 - O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists - Google Patents
O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists Download PDFInfo
- Publication number
- WO2008075150A1 WO2008075150A1 PCT/IB2007/003784 IB2007003784W WO2008075150A1 WO 2008075150 A1 WO2008075150 A1 WO 2008075150A1 IB 2007003784 W IB2007003784 W IB 2007003784W WO 2008075150 A1 WO2008075150 A1 WO 2008075150A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- trifluoromethyl
- benzyl
- urea
- methoxybenzyl
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
Abstract
Description
Claims
Priority Applications (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
UAA200904805A UA95986C2 (en) | 2006-12-21 | 2007-06-12 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
MX2009006582A MX2009006582A (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists. |
CA2673219A CA2673219C (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
BRPI0720421-3A BRPI0720421A2 (en) | 2006-12-21 | 2007-12-06 | DIBENZILA UREA DERIVATIVES REPLACED BY THE AS TRPV1 RECEIVER ANTAGONISTS |
DK07848984.6T DK2094653T3 (en) | 2006-12-21 | 2007-12-06 | O-substituted dibenzylurea derivatives as TRPV1 receptor antagonists |
NZ577796A NZ577796A (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
KR1020097012641A KR101460177B1 (en) | 2006-12-21 | 2007-12-06 | 0-substituted-dibenzyl urea-derivatives as TRPV1 receptor antagonists |
DE602007008942T DE602007008942D1 (en) | 2006-12-21 | 2007-12-06 | O-SUBSTITUTED DIBENZYLENE DERIVATIVES AS TRPV1 RECEPTOR ANTAGONISTS |
US12/519,753 US7750049B2 (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as TRPV1 receptor antagonists |
EA200900625A EA015152B1 (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
SI200730412T SI2094653T1 (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
PL07848984T PL2094653T3 (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
EP07848984A EP2094653B1 (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
JP2009542247A JP5302214B2 (en) | 2006-12-21 | 2007-12-06 | O-substituted dibenzylurea derivatives as TRPV1 receptor antagonists |
AT07848984T ATE479652T1 (en) | 2006-12-21 | 2007-12-06 | O-SUBSTITUTED DIBENZYL UREA DERIVATIVES AS TRPV1 RECEPTOR ANTAGONISTS |
CN2007800469258A CN101563317B (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
NO20092336A NO20092336L (en) | 2006-12-21 | 2009-06-18 | O-substituted-dibenzyl urea derivatives as TRPV 1 receptor antagonists |
IL199422A IL199422A (en) | 2006-12-21 | 2009-06-18 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
HR20100588T HRP20100588T1 (en) | 2006-12-21 | 2010-11-02 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06026533A EP1939173A1 (en) | 2006-12-21 | 2006-12-21 | O-substituted-dibenzyl urea- or thiourea- derivatives as trpv1 receptor antagonists |
EP06026533.7 | 2006-12-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008075150A1 true WO2008075150A1 (en) | 2008-06-26 |
Family
ID=38139789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2007/003784 WO2008075150A1 (en) | 2006-12-21 | 2007-12-06 | O-substituted-dibenzyl urea-derivatives as trpv1 receptor antagonists |
Country Status (25)
Country | Link |
---|---|
US (1) | US7750049B2 (en) |
EP (2) | EP1939173A1 (en) |
JP (1) | JP5302214B2 (en) |
KR (1) | KR101460177B1 (en) |
CN (1) | CN101563317B (en) |
AT (1) | ATE479652T1 (en) |
BR (1) | BRPI0720421A2 (en) |
CA (1) | CA2673219C (en) |
CY (1) | CY1110833T1 (en) |
DE (1) | DE602007008942D1 (en) |
DK (1) | DK2094653T3 (en) |
EA (1) | EA015152B1 (en) |
ES (1) | ES2347492T3 (en) |
HR (1) | HRP20100588T1 (en) |
IL (1) | IL199422A (en) |
MX (1) | MX2009006582A (en) |
NO (1) | NO20092336L (en) |
NZ (1) | NZ577796A (en) |
PL (1) | PL2094653T3 (en) |
PT (1) | PT2094653E (en) |
RS (1) | RS51555B (en) |
SI (1) | SI2094653T1 (en) |
UA (1) | UA95986C2 (en) |
WO (1) | WO2008075150A1 (en) |
ZA (1) | ZA200904278B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021235983A1 (en) | 2020-05-20 | 2021-11-25 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б.Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Drug with prolonged analgesic action |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009037707A2 (en) | 2007-09-20 | 2009-03-26 | Ramot At Tel Aviv University Ltd. | N-phenyl anthranilic acid derivatives and uses thereof |
JP7441042B2 (en) | 2016-12-02 | 2024-02-29 | シムライズ アーゲー | cosmetic blend |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002016318A1 (en) * | 2000-08-21 | 2002-02-28 | Pacific Corporation | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
WO2005123666A1 (en) * | 2004-06-18 | 2005-12-29 | Pharmeste S.R.L. | Vanilloid trpv1 receptor antagonists |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8715357D0 (en) * | 1987-06-30 | 1987-08-05 | Sandoz Inst For Medical Resear | Organic compounds |
GB9519270D0 (en) * | 1995-09-21 | 1995-11-22 | Sandoz Pharma Uk | Organic compounds |
JP2003192660A (en) * | 2001-12-26 | 2003-07-09 | Bayer Ag | Urea derivative |
US6858615B2 (en) * | 2002-02-19 | 2005-02-22 | Parion Sciences, Inc. | Phenyl guanidine sodium channel blockers |
-
2006
- 2006-12-21 EP EP06026533A patent/EP1939173A1/en not_active Withdrawn
-
2007
- 2007-06-12 UA UAA200904805A patent/UA95986C2/en unknown
- 2007-12-06 KR KR1020097012641A patent/KR101460177B1/en active IP Right Grant
- 2007-12-06 WO PCT/IB2007/003784 patent/WO2008075150A1/en active Application Filing
- 2007-12-06 EP EP07848984A patent/EP2094653B1/en active Active
- 2007-12-06 ES ES07848984T patent/ES2347492T3/en active Active
- 2007-12-06 PT PT07848984T patent/PT2094653E/en unknown
- 2007-12-06 AT AT07848984T patent/ATE479652T1/en active
- 2007-12-06 NZ NZ577796A patent/NZ577796A/en not_active IP Right Cessation
- 2007-12-06 RS RSP-2010/0441A patent/RS51555B/en unknown
- 2007-12-06 CA CA2673219A patent/CA2673219C/en active Active
- 2007-12-06 DK DK07848984.6T patent/DK2094653T3/en active
- 2007-12-06 JP JP2009542247A patent/JP5302214B2/en active Active
- 2007-12-06 US US12/519,753 patent/US7750049B2/en active Active
- 2007-12-06 DE DE602007008942T patent/DE602007008942D1/en active Active
- 2007-12-06 EA EA200900625A patent/EA015152B1/en not_active IP Right Cessation
- 2007-12-06 PL PL07848984T patent/PL2094653T3/en unknown
- 2007-12-06 ZA ZA200904278A patent/ZA200904278B/en unknown
- 2007-12-06 CN CN2007800469258A patent/CN101563317B/en active Active
- 2007-12-06 MX MX2009006582A patent/MX2009006582A/en active IP Right Grant
- 2007-12-06 BR BRPI0720421-3A patent/BRPI0720421A2/en not_active IP Right Cessation
- 2007-12-06 SI SI200730412T patent/SI2094653T1/en unknown
-
2009
- 2009-06-18 IL IL199422A patent/IL199422A/en active IP Right Grant
- 2009-06-18 NO NO20092336A patent/NO20092336L/en not_active Application Discontinuation
-
2010
- 2010-10-18 CY CY20101100925T patent/CY1110833T1/en unknown
- 2010-11-02 HR HR20100588T patent/HRP20100588T1/en unknown
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002016318A1 (en) * | 2000-08-21 | 2002-02-28 | Pacific Corporation | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
WO2005123666A1 (en) * | 2004-06-18 | 2005-12-29 | Pharmeste S.R.L. | Vanilloid trpv1 receptor antagonists |
Non-Patent Citations (1)
Title |
---|
RAMI ET AL: "Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 16, no. 12, 15 June 2006 (2006-06-15), pages 3287 - 3291, XP005422626, ISSN: 0960-894X * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021235983A1 (en) | 2020-05-20 | 2021-11-25 | Федеральное государственное бюджетное учреждение науки Тихоокеанский институт биоорганической химии им. Г.Б.Елякова Дальневосточного отделения Российской академии наук (ТИБОХ ДВО РАН) | Drug with prolonged analgesic action |
Also Published As
Publication number | Publication date |
---|---|
MX2009006582A (en) | 2009-07-02 |
CY1110833T1 (en) | 2015-06-10 |
PT2094653E (en) | 2010-09-23 |
CA2673219A1 (en) | 2008-06-26 |
ES2347492T3 (en) | 2010-10-29 |
EP2094653B1 (en) | 2010-09-01 |
CN101563317A (en) | 2009-10-21 |
ZA200904278B (en) | 2010-08-25 |
PL2094653T3 (en) | 2011-02-28 |
SI2094653T1 (en) | 2011-01-31 |
JP2010513455A (en) | 2010-04-30 |
US7750049B2 (en) | 2010-07-06 |
KR20090090347A (en) | 2009-08-25 |
UA95986C2 (en) | 2011-09-26 |
RS51555B (en) | 2011-06-30 |
US20100105740A1 (en) | 2010-04-29 |
DE602007008942D1 (en) | 2010-10-14 |
HRP20100588T1 (en) | 2010-12-31 |
CN101563317B (en) | 2012-12-12 |
EA015152B1 (en) | 2011-06-30 |
EP2094653A1 (en) | 2009-09-02 |
EA200900625A1 (en) | 2009-12-30 |
EP1939173A1 (en) | 2008-07-02 |
DK2094653T3 (en) | 2010-10-25 |
CA2673219C (en) | 2015-04-14 |
KR101460177B1 (en) | 2014-11-10 |
JP5302214B2 (en) | 2013-10-02 |
ATE479652T1 (en) | 2010-09-15 |
BRPI0720421A2 (en) | 2013-12-31 |
IL199422A (en) | 2015-01-29 |
NZ577796A (en) | 2011-10-28 |
NO20092336L (en) | 2009-06-18 |
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