WO2008067126A3 - Methods for using aldhbr cells to supplement stem cell transplantation - Google Patents

Methods for using aldhbr cells to supplement stem cell transplantation Download PDF

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Publication number
WO2008067126A3
WO2008067126A3 PCT/US2007/084022 US2007084022W WO2008067126A3 WO 2008067126 A3 WO2008067126 A3 WO 2008067126A3 US 2007084022 W US2007084022 W US 2007084022W WO 2008067126 A3 WO2008067126 A3 WO 2008067126A3
Authority
WO
WIPO (PCT)
Prior art keywords
methods
cells
stem cell
aldhbr
cell transplantation
Prior art date
Application number
PCT/US2007/084022
Other languages
French (fr)
Other versions
WO2008067126A2 (en
Inventor
Joanne Kurtzberg
N Rebecca Haley
Original Assignee
Aldagen Inc
Univ Duke
Joanne Kurtzberg
N Rebecca Haley
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aldagen Inc, Univ Duke, Joanne Kurtzberg, N Rebecca Haley filed Critical Aldagen Inc
Priority to CA002668608A priority Critical patent/CA2668608A1/en
Priority to JP2009536471A priority patent/JP2010509360A/en
Priority to US12/513,889 priority patent/US20100129329A1/en
Priority to EP07871405A priority patent/EP2089041A2/en
Publication of WO2008067126A2 publication Critical patent/WO2008067126A2/en
Publication of WO2008067126A3 publication Critical patent/WO2008067126A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates to methods repairing, regenerating, and reconstituting tissues by transplanting at least two stem cell populations, wherein the first and the second population of stem cells are introduced into a subject separated by a time interval of about 2 to about 24 hours. The first population comprises stem cells derived from umbilical cord. The second population comprises ALDHbr cells. These ALDHbr cells can be administered to a patient immediately after isolation or can be primed in culture using a combination of cytokines for about 2 to about 7 days prior to transplantation. The methods of the invention are useful in accelerating time to neutrophil and/or platelet engraftment and immune reconstitution following myeloablative therapy.
PCT/US2007/084022 2006-11-08 2007-11-08 Methods for using aldhbr cells to supplement stem cell transplantation WO2008067126A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002668608A CA2668608A1 (en) 2006-11-08 2007-11-08 Methods for using aldhbr cells to supplement stem cell transplantation
JP2009536471A JP2010509360A (en) 2006-11-08 2007-11-08 Methods of using ALDHbr cells to assist stem cell transplantation
US12/513,889 US20100129329A1 (en) 2006-11-08 2007-11-08 METHODS FOR USING ALDHbr CELLS TO SUPPLEMENT STEM CELL TRANSPLANTATION
EP07871405A EP2089041A2 (en) 2006-11-08 2007-11-08 Methods for using aldhbr cells to supplement stem cell transplantation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85754106P 2006-11-08 2006-11-08
US60/857,541 2006-11-08

Publications (2)

Publication Number Publication Date
WO2008067126A2 WO2008067126A2 (en) 2008-06-05
WO2008067126A3 true WO2008067126A3 (en) 2008-10-02

Family

ID=39330911

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2007/084022 WO2008067126A2 (en) 2006-11-08 2007-11-08 Methods for using aldhbr cells to supplement stem cell transplantation

Country Status (5)

Country Link
US (1) US20100129329A1 (en)
EP (1) EP2089041A2 (en)
JP (1) JP2010509360A (en)
CA (1) CA2668608A1 (en)
WO (1) WO2008067126A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202004145QA (en) * 2017-11-15 2020-06-29 Weird Science Llc Methods and compositions for non-myeloablative bone marrow reconstitution

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005083061A1 (en) * 2004-02-11 2005-09-09 Aldagen, Inc. Stem cell populations and methods of use
WO2005107807A2 (en) * 2004-05-06 2005-11-17 University Of South Florida Cerebral intraventricular transplantation as method of treating amyotrophic lateral sclerosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112969A (en) * 1994-03-17 2001-05-20 Baxter Int Pharmaceutical compositions for the treatment of cancer comprising allogenic lymphocytes or their combination with a t-cell activator
US20020159984A1 (en) * 1999-11-12 2002-10-31 Quality Biological, Inc. Cultivation of cells for long term engraftment

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005083061A1 (en) * 2004-02-11 2005-09-09 Aldagen, Inc. Stem cell populations and methods of use
WO2005107807A2 (en) * 2004-05-06 2005-11-17 University Of South Florida Cerebral intraventricular transplantation as method of treating amyotrophic lateral sclerosis

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FALLON P ET AL: "Mobilized peripheral blood SSClo ALDHbr cells have the phenotypic and functional properties of primitive haematopoietic cells and their number correlates with engraftment following autologous transplantation", BRITISH JOURNAL OF HAEMATOLOGY, OXFORD, GB, vol. 122, no. 1, 1 July 2003 (2003-07-01), pages 99 - 108, XP002306488, ISSN: 0007-1048 *
STORMS R W ET AL: "Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE, WASHINGTON, DC, vol. 96, no. 16, 3 August 1999 (1999-08-03), pages 9118 - 9123, XP002239067, ISSN: 0027-8424 *
STORMS ROBERT W ET AL: "Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34", BLOOD, vol. 106, no. 1, July 2005 (2005-07-01), pages 95 - 102,86, XP002490034, ISSN: 0006-4971 *
STORMS ROBERT W ET AL: "Multilineage hematopoietic development from umbilical cord blood cells with high aldehyde dehydrogenase activity", BLOOD, vol. 96, no. 11 Part 2, 16 November 2000 (2000-11-16), & 42ND ANNUAL MEETING OF THE AMERICAN SOCIETY OF HEMATOLOGY; SAN FRANCISCO, CALIFORNIA, USA; DECEMBER 01-05, 2000, pages 127b, XP009103530, ISSN: 0006-4971 *

Also Published As

Publication number Publication date
CA2668608A1 (en) 2008-06-05
JP2010509360A (en) 2010-03-25
WO2008067126A2 (en) 2008-06-05
EP2089041A2 (en) 2009-08-19
US20100129329A1 (en) 2010-05-27

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